• Terry, Jefferson

    Titles

    Investigator, BC Children's Hospital
    Division Head, Anatomical Pathology, BC Children's Hospital
    Pediatric and Perinatal Pathologist, Children's & Women's Health Centre of BC
    Clinical Assistant Professor, Department of Pathology and Laboratory Medicine, University of British Columbia

    Degrees / Designations

    MD, PhD

    Primary Area of Research
    Healthy Starts
    Secondary Area(s) of Research
    Phone
    604-875-3094
    Fax
    604-875-3529
    Lab Phone
    Mailing Address

    BC Children's Hospital
    4480 Oak Street
    Room 2H53
    Vancouver, BC V6H 3V4

    Affiliate Websites
    Research Areas
    • Placental gene expression studies
    • Amniotic fluid infection
    • Chorioamnionitis
    • Diagnostics
    • Inflammatory bowel disease
    Summary

    My research interests involve areas directly relevant to the clinical practice of pediatric and perinatal pathology. I am particularly interested in the development of novel diagnostic and prognostic markers to improve management of common diseases in infants and children.

    Current Projects

    I am currently working towards identifying biomarkers which could ultimately lead to the development of a test for early diagnosis of amniotic fluid infection syndrome (AFI). AFI involves acute inflammation of placental tissue surrounding the fetus typically and leads to preterm labor with significant risk of adverse health complications and mortality. Early detection may improve outcome.

    The role of bacterial triggers in the pathogenesis of Crohn's disease is another area of interest and I am presently developing an in situ assay for identification of potential trigger organisms in archival gastrointestinal tissue biopsies.

    I am also involved in a collaborative study investigating the application of a novel ultrasonography technique to improve intrauterine detection of placental lesions.  

    Selected Publications

    Beer PA, Knapp DJ, Miller PH, Kannan N, Sloma I, Heel K, Babovic S, Bulaeva E, Rabu G, Terry J, Druker BJ, Loriaux MM, Loeb KR, Radich JP, Erber WN, Eaves CJ. (2015). Disruption of IKAROS activity in primitive chronic phase CML cells mimics myeloid disease progression. Blood.  Jan 15;125(3):504-15. Epub 2014 Nov 4. PMID: 25370416

    Al-Mashaikhi N, Yang J, Terry J, Barr R. (2014). Renal Cell Carcinoma with Xp 11.2 Translocation as a Second Tumor in a Long-Term Survivor of Advanced Neuroblastoma. PediatrHematolOncol. 32(3): 215-22. PMID: 25551622

    Mahe E, Hamid J, Terry J, Jansen JW, Bourgeois J, Arredondo-Marin J. (2014). Frozen section of placental membranes and umbilical cord: an aid to early postpartum diagnosis of intra-amniotic infection. American journal of clinical pathology. 142(2): 202-8. PMID: 25015861

    Terry J, Rauen KA, Nowaczyk MJ. (2014). Fetal autopsy findings of cardiofaciocutaneous syndromewith a unique BRAF mutation. Pediatric and developmental pathology. 17(1): 59-63. PMID: 24303953

    Bates SV, Lakshmanan A, Green AL, Terry J, Badalian-Very G, Rollins BJ, Fleck P, Aslam M, Degar BA. (2013). BRAF V600E-Positive Multisite Langerhans Cell Histiocytosis in a Preterm Neonate. AJP reports. 3(2): 63-6. PMID: 24147236

    Terry J, Pluchinotta FR, Sanders SP, Vergilio JA, Hyde SR, Boyd TK. (2013). Congenital langerhanscell histiocytosis with placental involvement. Pediatric and developmental pathology. 16(3): 224-8. PMID: 23432454

    Terry J, Tapas M , Nowaczyk MJ. (2013). Prenatal and pathologic features of aorto-left ventricular tunnel causing fetal hydrops and intrauterine demise. Pediatric and developmental pathology. 16(2): 97-101. PMID: 23286355

    Terry J, Calicchio ML , Rodriguez-Galindo C , Perez-Atayde AR. (2012). Immunohistochemical expression of CRX in extracranial malignant small round cell tumors. The American journal of surgicalpathology. 36(8): 1165-9. PMID: 22790857

    Forester CM, Terry J, Lee EY, Simoneau T, Haver K. (2012). Skin lesions and lung cysts in a neonate. The Journal of pediatrics. 160(6): 1061-1.e1. PMID: 22404953

    Terry J, De Luca A, Leung S, Peacock G, Wang Y, Elliot WM, Huntsman D. (2011). Immunohistochemical expression of neurotrophic tyrosine kinase receptors 1 and 2 in lung carcinoma: potential discriminators between squamous and nonsquamous subtypes. Archives of pathology & laboratory medicine. 135(4): 433-9. PMID: 21466358

    Ragotte RJ, Dhanrajani A, Pleydell-Pearce J, Del Bel KL, Tarailo-Graovac M, van Karnebeek C, Terry J, Senger C, McKinnon ML, Seear M, Prendiville JS, Tucker LB, Houghton K, Cabral DA, Guzman J, Petty RE, Brown KL, Tekano J, Wu J, Morishita KA, Turvey SE. The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus. Clin Immunol. 2016 Dec 31 PMID: 28043923 
    Grants

    2015, Young Investigator Research Grant, Society for Pediatric Pathology
    2015, Clinical and Translational Research Seed Grant, Child and Family Research Centre
    2015, Pathology and Laboratory Medicine Microgrant, BC Children's and Women's Hospital
    2012, New Investigator Fund, Hamilton Health Sciences
    2011, Research Start-up Fund, McMaster University

    Honours & Awards

    2011, Lotte Strauss Prize, Society for Pediatric Pathology
    2009, Annual Research Symposium, 1st Place, UBC Department of Pathology & Lab Medicine
    2009, Trainee Research Award, Pulmanry Pathology Pathology Society
    2008, Annual Research Symposium, 2ndPlace, UBC Department of Pathology & Lab Medicine

    Research Group Members