When Sam Maloney was a baby, his poop was green. He was sick all the time. He wasn’t thriving. Sam’s mom Tara Blaney knew something was wrong. But it wasn’t until he was 18 months old, weighing only 18 pounds, that Tara first heard the words “cystic fibrosis”. She had never heard of it before and when she Googled it, her entire world changed.
- Overview
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I am interested in the development of new tools that will help us detect lung disease in children. Specifically, this includes new, more sensitive breathing tests that will help us measure lung function in children. As well, I am interested in developing new imaging tests (such as MRI) that will help us see the structure of the lung.
My research focuses primarily, but not exclusively, on patients with cystic fibrosis.
- Publications
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Frequent microbiological surveillance during inpatient cystic fibrosis pulmonary exacerbations has limited clinical value
Journal of Cystic Fibrosis
Wendy HC Song and Kendrew SK Wong and David M. Goldfarb and Jeffrey N Bone and Jonathan H Rayment
DOI: 10.1016/j.jcf.2023.10.007
10/2023Multiple breath washout and oscillometry after allogenic HSCT: a scoping review
European Respiratory Review
Nicole Sonneveld and Jonathan H. Rayment and Jakob Usemann and Kim G. Nielsen and Paul D. Robinson
DOI: 10.1183/16000617.0251-2022
09/2023Heterogenous Disease Course and Long-Term Outcome of Children’s Interstitial Lung Disease Related to Filamin A Gene Variants
Annals of the American Thoracic Society
Julia Carlens and K. Taneille Johnson and Andrew Bush and Diane Renz and Ute Hehr and Florian Laenger and Claire Hogg and Martin Wetzke and Nicolaus Schwerk and Jonathan H. Rayment
DOI: 10.1513/AnnalsATS.202202-142OC
12/2022A Phase 3, Open-Label Study of Lumacaftor/Ivacaftor in Children 1 to Less Than 2 Years of Age with Cystic Fibrosis Homozygous for F508del-CFTR
American Journal of Respiratory and Critical Care Medicine
Jonathan H. Rayment and Fadi Asfour and Margaret Rosenfeld and Mark Higgins and Lingyun Liu and Molly Mascia and Hildegarde Paz-Diaz and Simon Tian and Rachel Zahigian and Susanna A. McColley
DOI: 10.1164/rccm.202204-0734OC
11/2022CFTR modulators increase risk of acute pancreatitis in pancreatic insufficient patients with cystic fibrosis
Journal of Cystic Fibrosis
Michelle J. Gould and Haley Smith and Jonathan H Rayment and Helen Machida and Tanja Gonska and Gary J. Galante
DOI: 10.1016/j.jcf.2021.09.010
07/2022Multiple Breath Washout Testing to Identify Pulmonary Chronic Graft Versus Host Disease in Children After Hematopoietic Stem Cell Transplantation
Transplantation and Cellular Therapy
Jonathan H. Rayment and Rodrigo A. Sandoval and Juliana P. Roden and Kirk R. Schultz
DOI: 10.1016/j.jtct.2022.02.002
06/2022Pulmonary functional MRI: Detecting the structure–function pathologies that drive asthma symptoms and quality of life
Respirology
Kooner, H.K. and McIntosh, M.J. and Desaigoudar, V. and Rayment, J.H. and Eddy, R.L. and Driehuys, B. and Parraga, G.
DOI: 10.1111/resp.14197
2022The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial
The Lancet Respiratory Medicine
Tiddens, H.A.W.M. and Chen, Y. and Andrinopoulou, E.-R. and Davis, S.D. and Rosenfeld, M. and Ratjen, F. and Kronmal, R.A. and Hinckley Stukovsky, K.D. and Dasiewicz, A. and Stick, S.M. and Anthony, M.M. and Au, J. and Belessis, Y. and Bonte, M. and Cheney, J. and Clem, C. and Clements, B. and Cooper, P. and Davis, S.D. and Davis, M. and de Boeck, K. and de Marchis, M. and De Wachter, E. and Delaisi, B. and Delaup, V. and DeRicco, A. and Foti, A. and Gan, R. and Garriga, L. and Gartner, S. and Genatossio, A. and Grogan, S. and Hilton, J. and Hoppe, J.E. and Janssens, H.M. and Jensen, R. and Johnson, R. and Kemner-van de Corput, M.P.C. and Klein, B. and Kronmal, R.A. and Lucca, F. and Lucidi, V. and Montemitro, E. and Nahidi, L. and Nielsen, K.G. and Pearce, K. and Pittman, J.E. and Powers, M. and Prentice, C. and Pressler, T. and Rayment, J.H. and Reix, P. and Retsch-Bogart, G. and Riera, L. and Robinson, P. and Robinson, P. and Sanders, D.B. and Sandoval, R.A. and Sandvik, R.M. and Saunders, C. and Siegel, M. and Smith, J. and Solomon, M. and Stanojevic, S. and Tai, A. and Tiddens, H.A.W.M. and van de Puttelaar, J. and Van den Brande, C. and van Straten, M. and Vermeulen, F. and Volpi, S. and Wainwright, C.E. and Weiner, D.J. and Yuan, Y. and Zaimeddine, S.
DOI: 10.1016/S2213-2600(21)00546-4
2022All hands on deck: A multidisciplinary approach to SARS-CoV-2-associated MIS-C
Paediatrics and Child Health (Canada)
Lopez, A.A. and Patel, M. and Rayment, J.H. and Tam, H. and Roberts, A. and Laskin, S. and Tucker, L. and Biggs, C.M. and Ahmed, M.A. and Barakauskas, V. and Galanis, E. and Goldfarb, D. and Halparin, J. and Harris, K.C. and Kissoon, N. and Lawrence, S. and McGuffin, D. and Meckler, G. and Noel, K. and Schrader, D. and Sherwood, M. and Singh, A. and Vercauteren, S.
DOI: 10.1093/pch/pxab110
2022A Phase 3, Open-Label Study of Lumacaftor/Ivacaftor in Children 1 to Less Than 2 Years of Age with Cystic Fibrosis Homozygous for F508del-CFTR
American Journal of Respiratory and Critical Care Medicine
Rayment, J.H. and Asfour, F. and Rosenfeld, M. and Higgins, M. and Liu, L. and Mascia, M. and Paz-Diaz, H. and Tian, S. and Zahigian, R. and McColley, S.A.
DOI: 10.1164/RCCM.202204-0734OC
2022Diffuse alveolar haemorrhage in a child with trisomy 21
Journal of Paediatrics and Child Health
Susan Telencoe and Ajay C Kevat and Anna F Lee and Jonathan H Rayment
DOI: 10.1111/jpc.15331
10/2021Editorial for “Flow Volume Loop and Regional Ventilation Assessment Using Phase Resolved Functional Lung (PREFUL) MRI: Comparison With 129Xenon Ventilation MRI and Lung Function Testing”
Journal of Magnetic Resonance Imaging
Rachel L. Eddy and Jonathan H. Rayment
DOI: 10.1002/jmri.27462
04/2021Free-breathing MRI for monitoring ventilation changes following antibiotic treatment of pulmonary exacerbations in paediatric cystic fibrosis
European Respiratory Journal
Samal Munidasa and Marcus J. Couch and Jonathan H. Rayment and Andreas Voskrebenzev and Ravi Seethamraju and Jens Vogel-Claussen and Felix Ratjen and Giles Santyr
DOI: 10.1183/13993003.03104-2020
04/2021Factors influencing clinical trial participation for adult and pediatric patients with cystic fibrosis
Journal of Cystic Fibrosis
Lee, M. and Hu, X.Y. and Desai, S. and Kwong, E. and Fu, J. and Flores, E. and Lazosky, L. and Wilcox, P.G. and Mcllwaine, M. and Chilvers, M. and Yang, C. and Rayment, J.H. and Quon, B.S.
DOI: 10.1016/j.jcf.2020.08.019
2021Comparison of Functional Free-Breathing Pulmonary 1H and Hyperpolarized 129Xe Magnetic Resonance Imaging in Pediatric Cystic Fibrosis
Academic Radiology
Couch, M.J. and Munidasa, S. and Rayment, J.H. and Voskrebenzev, A. and Seethamraju, R.T. and Vogel-Claussen, J. and Ratjen, F. and Santyr, G.
DOI: 10.1016/j.acra.2020.05.008
2021A phase 3 open-label study of elexacaftor/tezacaftor/ivacaftor in children 6 through 11 years of age with cystic fibrosis and at least one F508del allele
American Journal of Respiratory and Critical Care Medicine
Zemanick, E.T. and Taylor-Cousar, J.L. and Davies, J. and Gibson, R.L. and Mall, M.A. and McKone, E.F. and McNally, P. and Ramsey, B.W. and Rayment, J.H. and Rowe, S.M. and Tullis, E. and Ahluwalia, N. and Chu, C. and Ho, T. and Moskowitz, S.M. and Noel, S. and Tian, S. and Waltz, D. and Weinstock, T.G. and Xuan, F. and Wainwright, C.E. and McColley, S.A.
DOI: 10.1164/rccm.202102-0509OC
2021Protocols for multi-site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129Xe MRI clinical trials consortium
Magnetic Resonance in Medicine
Niedbalski, P.J. and Hall, C.S. and Castro, M. and Eddy, R.L. and Rayment, J.H. and Svenningsen, S. and Parraga, G. and Zanette, B. and Santyr, G.E. and Thomen, R.P. and Stewart, N.J. and Collier, G.J. and Chan, H.-F. and Wild, J.M. and Fain, S.B. and Miller, G.W. and Mata, J.F. and Mugler, J.P. and Driehuys, B. and Willmering, M.M. and Cleveland, Z.I. and Woods, J.C.
DOI: 10.1002/mrm.28985
2021Sustained recovery of exocrine pancreatic function in a teenager with cystic fibrosis treated with ivacaftor
Pediatric Pulmonology
Haley Smith and Jonathan H. Rayment
DOI: 10.1002/ppul.24952
10/2020Assessing the feasibility of hyperpolarized 129Xe multiple-breath washout MRI in pediatric cystic fibrosis
Magnetic Resonance in Medicine
Couch, M.J. and Morgado, F. and Kanhere, N. and Kowalik, K. and Rayment, J.H. and Ratjen, F. and Santyr, G.
DOI: 10.1002/mrm.28099
2020An investigation into biomarkers for the diagnosis of ABPA and aspergillus disease in cystic fibrosis.
Pediatric pulmonology
Keown K and Abbott S and Kuzeljevic B and Rayment JH and Chilvers MA and Yang CL
DOI: 10.1002/ppul.24465
PubMed: 31359612
07/2019Hyperpolarised129Xe magnetic resonance imaging to monitor treatment response in children with cystic fibrosis
European Respiratory Journal
Jonathan H. Rayment and Marcus J. Couch and Nancy McDonald and Nikhil Kanhere and David Manson and Giles Santyr and Felix Ratjen
DOI: 10.1183/13993003.02188-2018
05/2019Prolidase deficiency diagnosed by whole exome sequencing in a child with pulmonary capillaritis
ERJ Open Research
Jonathan H. Rayment and Rebekah Jobling and Sarah Bowdin and Ernest Cutz and Sharon D. Dell
DOI: 10.1183/23120541.00205-2018
04/2019Hyperpolarized Gas Magnetic Resonance Imaging of Pediatric Cystic Fibrosis Lung Disease
Academic Radiology
Giles Santyr and Nikhil Kanhere and Felipe Morgado and Jonathan H. Rayment and Felix Ratjen and Marcus J. Couch
DOI: 10.1016/j.acra.2018.04.024
03/2019The lung clearance index as a monitoring tool in cystic fibrosis
Current Opinion in Pulmonary Medicine
DOI: 10.1097/mcp.0000000000000515
08/2018Back to the source – Modern insights into pulmonary exacerbations and lung function decline from CF registry data
Journal of Cystic Fibrosis
DOI: 10.1016/j.jcf.2018.05.001
07/2018Lung clearance index to monitor treatment response in pulmonary exacerbations in preschool children with cystic fibrosis
Thorax
Jonathan H Rayment and Sanja Stanojevic and Stephanie D Davis and George Retsch-Bogart and Felix Ratjen
DOI: 10.1136/thoraxjnl-2017-210979
05/2018Reply to Verbanck and Vanderhelst: The Respective Roles of Lung Clearance Index and Magnetic Resonance Imaging in the Clinical Management of Patients with Cystic Fibrosis.
American journal of respiratory and critical care medicine
Kanhere N and Couch MJ and Rayment JH and Ratjen F and Santyr G and all authors
DOI: 10.1164/rccm.201707-1392le
PubMed: 28800249
02/2018Reply to Verbanck and Vanderhelst
American Journal of Respiratory and Critical Care Medicine
Kanhere, N. and Couch, M.J. and Rayment, J.H. and Ratjen, F. and Santyr, G.
DOI: 10.1164/rccm.201707-1392LE
2018The lung clearance index as a monitoring tool in cystic fibrosis: Ready for the clinic?
Current Opinion in Pulmonary Medicine
Perrem, L. and Rayment, J.H. and Ratjen, F.
DOI: 10.1097/MCP.0000000000000515
2018Correcting for tissue nitrogen excretion in multiple breath washout measurements
PLOS ONE
Mica Kane and Jonathan H. Rayment and Renee Jensen and Reginald McDonald and Sanja Stanojevic and Felix Ratjen
DOI: 10.1371/journal.pone.0185553
10/2017Correlation of Lung Clearance Index with Hyperpolarized 129Xe Magnetic Resonance Imaging in Pediatric Subjects with Cystic Fibrosis.
American journal of respiratory and critical care medicine
Kanhere N and Couch MJ and Kowalik K and Zanette B and Rayment JH and Manson D and Subbarao P and Ratjen F and Santyr G
DOI: 10.1164/rccm.201611-2228le
PubMed: 28245140
10/2017Another Brick in the Wall: Lung Clearance Index and Lower Airways Pathology in Preschool Cystic Fibrosis
Annals of the American Thoracic Society
Jonathan H. Rayment and Felix Ratjen
DOI: 10.1513/AnnalsATS.201706-432ED
09/2017Another Brick in the Wall: Lung Clearance Index and Lower Airways Pathology in Preschool Cystic Fibrosis.
Annals of the American Thoracic Society
Rayment JH and Ratjen F
DOI: 10.1513/annalsats.201706-432ed
PubMed: 28862497
09/2017Chronic Hypoxemia in a 2-Year-Old Boy
Annals of the American Thoracic Society
Jonathan H. Rayment and Oneza Ahmareen and Philip R. John and Felix Ratjen
DOI: 10.1513/AnnalsATS.201701-069CC
08/2017Chronic Hypoxemia in a 2-Year-Old Boy.
Annals of the American Thoracic Society
Rayment JH and Ahmareen O and John PR and Ratjen F
DOI: 10.1513/annalsats.201701-069cc
PubMed: 28763268
08/2017Concomitant Diffuse Alveolar Hemorrhage and Pulmonary Embolism in a Child with Isolated Pulmonary Capillaritis.
Annals of the American Thoracic Society
Rayment JH and Cutz E and Levy DM and Dell SD
DOI: 10.1513/annalsats.201610-783le
PubMed: 28248576
03/2017Correlation of lung clearance index with hyperpolarized 129xe magnetic resonance imaging in pediatric subjects with cystic fibrosis
American Journal of Respiratory and Critical Care Medicine
Kanhere, N. and Couch, M.J. and Kowalik, K. and Zanette, B. and Rayment, J.H. and Manson, D. and Subbarao, P. and Ratjen, F. and Santyr, G.
DOI: 10.1164/rccm.201611-2228LE
2017Concomitant diffuse alveolar hemorrhage and pulmonary embolism in a child with isolated pulmonary capillaritis
Annals of the American Thoracic Society
Rayment, J.H. and Cutz, E. and Levy, D.M. and Dell, S.D.
DOI: 10.1513/AnnalsATS.201610-783LE
2017Constrictive Bronchiolitis: A Distinct Phenotype of Cystic Fibrosis Lung Disease?
Annals of the American Thoracic Society
Rayment JH and Ratjen F
DOI: 10.1513/annalsats.201609-701ed
PubMed: 27925783
12/2016ATS Core Curriculum 2016: Part III. Pediatric Pulmonary Medicine.
Annals of the American Thoracic Society
Boyer D and Thomson CC and Cohen R and Rao D and Dell S and Rayment J and Wang R and Dy FJ and Wambach J and Tam-Williams J and Simon D and Price E and Oermann CM and Singh A and Rettig JS and Moore PE
DOI: 10.1513/annalsats.201602-097cme
PubMed: 27295156
06/2016Culture-positive Pediatric Tuberculosis in Toronto, Ontario: Sources of Infection and Relationship of Birthplace and Mycobacterial Lineage to Phenotype.
The Pediatric infectious disease journal
Rayment JH and Guthrie JL and Lam K and Whelan M and Lee B and Jamieson FB and Kitai I
DOI: 10.1097/inf.0000000000000915
PubMed: 26379168
01/2016Pulmonary Aspergillosis in a Previously Healthy 13-Year-Old Boy.
Canadian Respiratory Journal : Journal of the Canadian Thoracic Society
Rayment JH and Narang I
DOI: 10.1155/2016/4575942
PubMed: 27445540
2016Constrictive bronchiolitis: A distinct phenotype of cystic fibrosis lung disease?
Annals of the American Thoracic Society
Rayment, J.H. and Ratjen, F.
DOI: 10.1513/AnnalsATS.201609-701ED
2016ATS core curriculum 2016: Part III. Pediatric pulmonary medicine
Annals of the American Thoracic Society
Boyer, D. and Thomson, C.C. and Cohen, R. and Rao, D. and Dell, S. and Rayment, J. and Wang, R. and Dy, F.J. and Wambach, J. and Tam-Williams, J. and Simon, D. and Price, E. and Oermann, C.M. and Singh, A. and Rettig, J.S. and Duncan, E.D. and Baker, C.D. and Liptzin, D.R. and Moore, P.E.
DOI: 10.1513/AnnalsATS.201602-097CME
2016Culture-positive pediatric tuberculosis in Toronto, Ontario
Pediatric Infectious Disease Journal
Rayment, J.H. and Guthrie, J.L. and Lam, K. and Whelan, M. and Lee, B. and Jamieson, F.B. and Kitai, I.
DOI: 10.1097/INF.0000000000000915
2016An unusual cause of empyema in a teenage boy.
CMAJ : Canadian Medical Association Journal
Rayment JH and Weinstein M
DOI: 10.1503/cmaj.122089
PubMed: 23798451
09/2013Impact of the sentinel node frozen section result on the probability of additional nodal metastases as predicted by the MSKCC nomogram in breast cancer.
Japanese journal of clinical oncology
Jamal MH and Rayment JH and Meguerditchian A and Doi SA and Meterissian S
DOI: 10.1093/jjco/hyq225
PubMed: 21149238
03/2011Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.
Oncogene
Pontier SM and Huck L and White DE and Rayment J and Sanguin-Gendreau V and Hennessy B and Zuo D and St-Arnaud R and Mills GB and Dedhar S and Marshall CJ and Muller WJ
DOI: 10.1038/onc.2010.86
PubMed: 20305688
06/2010Addressing the role of cell adhesion in tumor cell dormancy.
Cell cycle (Georgetown, Tex.)
White DE and Rayment JH and Muller WJ
DOI: 10.4161/cc.5.16.2993
PubMed: 16880738
08/2006Amino acids as placeholders: base-composition pressures on protein length in malaria parasites and prokaryotes.
Applied bioinformatics
Rayment JH and Forsdyke DR
DOI: 10.2165/00822942-200504020-00005
PubMed: 16128613
2005 - Research
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Current Projects
Due to the remarkable advances in the care of children with cystic fibrosis (CF) over the past 3 decades, the traditional pulmonary function tests in most paediatric CF patients are normal. Despite this, we know that there is structural damage, inflammation and infection in the lungs of these children from an early age. In addition, new medical therapies for CF are leading to a monumental shift in how this disease is treated -- but again, if traditional pulmonary function testing is "normal" at the onset of therapy, it will not be sufficient to monitor response to treatment. For these reasons, new markers of lung health and disease are needed in this population. My research interests focus on the development of two types or pulmonary biomarkers: pulmonary function and imaging.
Multiple breath washout (MBW) testing is an old technique that has re-emerged in the literature over the past decade because it is extremely sensitive to the small airways disease that we see in early CF lung disease. There is, however, much that we don't know about this testing modality: how can/should it be used in a clinical setting? What constitutes a significant change between visits? Should a significant change in MBW outcomes prompt a change in clinical management? Through industry-initiated clinical trials and investigator-initiated studies, we hope to address these questions about this exciting new test.
Magnetic responance imaging is traditionally ineffective for imaging lung tissues, to its low proton density and high number of air/tissue interfaces. Novel techniques such as ultrashort echo time (UTE) MRI are improving the spatial resolution of pulmonary MRI, and are now being tested in children with CF. In addition, gas contrast imaging of the lungs using inhaled hyperpolarized noble gases (helium or xenon) allows for functional imaging. In collaboration with partners at UBC and St Paul's Hospital, I hope to develop a pediatric lung imaging research group at BCCH to use these emerging technologies in the investigation and care of children with lung disease.GrantsCF Canada Clinical Fellowship 2016-17
Honours & Awards2017 North American Cystic Fibrosis Conference Junior Clinical Investigator of the Year
Research Group MembersAysha Ayub, FLEX Student
Vanessa Diamond, Graduate Research Assistant, Graduate Student
Rachel Eddy, Postdoctoral Fellow, Postdoctoral Fellow
Loraine Fabri, Respiratory Clinical Fellow
Jennifer Kwan, Research Ethics and Compliance Coordinator
Fitzpatrick Laddaran
Reece Long, FLEX Research Trainee
Semipe Oni, Resident
Rodrigo Sandoval, Clinical Research Coordinator , Clinical Research Coordinator
Wendy Song
Valerie Swanston, Medical Student Researcher
