• Wang, Li

    Titles

    Investigator, BC Children's Hospital
    Medical Biochemist, BC Children's Hospital
    Clinical Assistant Professor, Department of Pathology and Laboratory Medicine, University of British Columbia

    Degrees / Designations
    MSc, MD
    Primary Area of Research
    Healthy Starts
    Secondary Area(s) of Research
    Phone
    604-875-2918
    Fax
    Lab Phone
    Mailing Address

    Children's & Women's Health Centre of BC
    Room 2J5
    4500 Oak Street
    Vancouver, BC V6H 3N1

    Affiliate Websites
    Research Areas
    • Preeclampsia
    • Pediatric toxicology 
    • Endocrine disorders 
    • Method development 
    • Point of care testing
    Summary

    My research focuses on development and improvement of biochemical laboratory measures for improved diagnoses of both maternal and neonatal health issues.

    Current Projects

    Whole blood measurement of bilirubin:  Bilirubin is routinely measured in infants before discharge to screen for hyperbilirubinemia (jaundice). Early detection prevents brain damage that may occur with high levels of bilirubin. I am currently investigating new methods to assess bilirubin with whole blood. This project compares whole blood bilirubin measurement to plasma bilirubin measurement to verify accuracy, efficiency and quality and assess factors which might interfere with the whole blood method.  If successful, this will enable assessment using much smaller blood sample volumes and producing faster results at the point of care. 

    Biomarkers of preeclampsia: Early diagnosis of preeclampsia can potentially prevent some of the adverse outcomes associated with this disease. However, early diagnosis of this disease is currently limited by a lack of clinical tests in this area. There is increasing evidence that an enzyme that breaks down tryptophan, an amino acid essential in the diet, is involved in the development of preeclampsia. I am assessing the levels of tryptophan and its metabolites in maternal blood to see whether they can be used to identify patients with preeclampsia in the second trimester of pregnancy before preeclampsia would typically be diagnosed. The development of a new test to predict preeclampsia and its complications will help clinicians provide an accurate diagnosis early in pregnancy and modify patient care accordingly, thus allowing them to provide the best care for both mothers and babies.

    Selected Publications

    Wang L, Larkins N, Jung B, Au N and Mammen C. Acute encephalopathy in a kidney transplant recipient following infusion of intravenous immunoglobulin. Transplant Intern published online: 22 Aug, 2014. PMID: 24964219

    Wang L, Sievenpiper J, De Souza R, Thomaz M,  Blatz S,  Balion C, Fusch C and  Grey V.  Hematocrit correction does not improve glucose meter accuracy in the assessment of neonatal hypoglycemia. Clin Chem Lab Med. 2013 Feb;18:1-9. PMID: 23420286

    Wang L and Chan PC. Measurement of uncertainty for the serum free light chain assays: estimation and implication on result interpretation. Clin Biochem. 2013 Mar;46(4-5):381-4. PMID: 23200885

    Kavsak PA, Mansour M, Wang L, Campeau S, Clark L, Brooks D, Trus M. Assessing pneumatic tube systems using patient specific populations and laboratory derived criteria. 

    Clin Chem. 2012 Apr;58(4):792-5. PMID: 22291142

    Kavsak PA, Wakefied N, Clark L, Lyko L, Pickersgill R, Wang L, Zeidler J. Roche acetaminophen assay negative bias at low concentrations is improved using the TDM diluent as the zero calibrator. Clin Biochem. 2010 Jun; 43(9):782.

    Grants

    Evaluation of the role of maternal tryptophan and kynurenine pathway metabolites in early diagnosis of preeclampsia.  Clinical Translational Research Seed Grant, Child & Family Research Institute (2014-2015).  

    Ultra performance liquid chromatography-Tandem mass spectrometry (UPLC-MS/MS) determination of tryptophan and kynurenines in urine and plasma samples.  Resident Research Grant, Department of Pathology & Molecular Medicine, McMaster University (2011).

    Evaluation of new glucose meter (Abbott-PXP) in Neonates. Resident Research Grant, Department of Pathology & Molecular Medicine, McMaster University (2010).

    Honours & Awards

    Best poster presentation, The XIIIth International Congress of Pediatric Laboratory Medicine, Istanbul, 2014.

    First place for oral presentation, CAMB (Canadian Association of Medical Biochemists) annual meeting, Montreal, November 2012.

    First place for best case report/series presentation, Department of Pathology & Molecular Medicine, Resident Research Day, McMaster University, May 2012.

    Physicians’ Services Incorporated (PSI) Foundation Resident Prize, July 2011.

    Second place for best paper presentation, Department of Pathology & Molecular Medicine, Resident Research Day, McMaster University, May 2011.

    Quality Assurance Award from postgraduate office of McMaster University, July 2010.

    First place for best paper presentation, Department of Pathology & Molecular Medicine, Resident Research Day, McMaster University, May 2010.

    Research Group Members