• Chilvers, Mark

    Titles

    Investigator, BC Children's Hospital
    Clinical Associate Professor, Division of Respiratory Medicine, Department of Pediatrics, Faculty of Medicine, University of British Columbia

    Degrees / Designations
    MB ChB, MD, BSc, MRCPCH
    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Phone
    604-875-2345 ext. 4930
    Fax
    604-875-3293
    Lab Phone
    Mailing Address

    BC Children's Hospital
    Room 1C16
    4480 Oak Street
    Vancouver, BC, V6H 3V4

    Affiliate Websites
    Research Areas
    • Cilia
    • Non-CF Bronchiectasis
    • Cystic Fibrosis
    • Pediatric Respirology
    • Clinical Trials
    Summary

    Respiratory 
    Over the last 15 years I have developed a research interest into non-CF Bronchiectasis. This focused primarily on primary ciliary dyskinesia. I developed a new method for the evaluation of function of the microscopic hairs (cilia) which line the airways of the lung. This has been standardized and now used as an accepted method for the diagnosis of primary ciliary dyskinesia and research platform.

    Cystic Fibrosis
    Cystic Fibrosis (CF) research is another significant research area. I am the PI on several clinical trials looking at new medications in CF patients. 

    I coordinate the CF clinic multidisciplinary research program and this is promoting research into nursing, physiotherapy, pharmacy and dietetic issues within CF. Current themes are transitional care to adulthood; physiotherapy interventions; location of CF care and outcome in adolescence and adherence to medication. We work closely with the adult CF clinic at St. Paul's on several joint projects.  

    Current Projects
    Establishment of Digitial high speed video in the diagnosis of primary ciliary dyskinesia in BC.
    Principal investigator for this trial
    Funded: Telethon

    Adherence to therapy in CF patients
    Co PI:
    Self funded.
    Evalaution of adherance therapy in CF patients. ldentifying bariers to adherance wuithin BC. This is a joint project with St Pauls.

    Evalaution of a transitional pathway in CF care
    This is a rewtrospective analysis of an quality improvement project to inpmprove health care in CF youth.
    Selected Publications
    1. O’Callaghan C, Sikand K, Chilvers MA.  Analysis of ependymal ciliary beat pattern and beat frequency using high speed imaging: comparison with the photomultiplier and photodiode methods.  Cilia 2012, 1:8

    2. McDougall CM, Culham G, Seear MD, Chilvers MA. Superior herniation of the mediastinum presenting as an anterior neck mass on straining. Pediatr Pulmonol. 2012 Jul;47(7):710-2. 

    3. Gravelle AM, Davidson G, Chilvers M.  Cystic Fibrosis adolescent transition care in Canada:  a snapshot of current practice.  Paediatrics & Child Health Dec 2012 (in press).

    4. Davidson AGF, Chilvers MA, Lillquist YP. Effects of a Pseudomonas aeruginosa eradication policy in a cystic fibrosis clinic.  Curr Opin Pulm Med. 2012 Sep 15. [Epub ahead of print]

    5. Tang A, Sharma A, Jen R, Hirschfeld AG, Chilvers MA, Lavoie PM, Turvey SE.   Inflammasome-mediated IL-1ß production in humans with cystic fibrosis.  PLoS One.2012; 7(5):e37689.  Epub 2012 May 23.

    6. Luu K, Chilvers M.  Chronic cough in a Vietnamese adolescent: Should we be sweating? Paediatr Child Health. 2011 Oct;16(8):465-6.

    7. Blohmke CJ, Park J, Hirschfeld AF, Victor RE, Schneiderman J, Stefanowicz D, Chilvers MA, Durie PR, Corey M, Zielenski J, Dorfman R, Sandford AJ, Daley D, Turvey SE. TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis.  J Immunol. 2010 Dec 15;185(12):7731-8. Epub 2010 Nov 10. 

    8. Prestidge C, Chilvers MA, Davidson AG, Cho E, McMahon V, White CT. Renal function in pediatric cystic fibrosis patients in the first decade of life.  Pediatr Nephrol. 2010 Dec 29. [Epub ahead of print] 

    9. McIlwaine M, Wong LT, Chilvers M, Davidson AG. Long-Term Comparative Trial of Two Different Physiotherapy Techniques; Postural Drainage With Percussion and Autogenic Drainage, in the treatment of Cystic Fibrosis. Pediatr Pulmonol. 2010;45(11):1064-9

    10. Stannard WA, Chilvers MA, Rutman AR, Williams CD, O'Callaghan C . Diagnostic testing of patients suspected of primary ciliary dyskinesia. Am J Respir Crit Care Med. 2010 Feb 15;181(4):307-14. 
    Grants
    Telethon Award 2009
    Honours & Awards
    Research Group Members