Overview

My research centers on various aspects of pediatric neurology, primarily epilepsy and surgical management of epilepsy.

Epilepsy is the most common chronic neurological disorder in children and is characterized by recurrent unprovoked seizures due to uncontrolled electrical activity in the brain. Thirty per cent or more of epilepsy cases do not respond to conventional epileptic medications. Other treatments for epilepsy are epilepsy surgery, vagus nerve stimulation, the ketogenic diet and investigational anti-epileptic drugs.

The epilepsy surgery program at BC Children’s Hospital was established in the mid 90s. My research focuses on outcomes following epilepsy surgery of various types and the influence of surgery on seizure control, quality of life, learning and attention. I am also involved in research in video-EEG monitoring, psychogenic non-epileptic seizures, psychiatric comorbidity in epilepsy and adverse reactions to anti-epileptic drugs.

Publications

Trajectory of Health-Related Quality of Life After Pediatric Epilepsy Surgery
JAMA Network Open
Elysa Widjaja and Klajdi Puka and Kathy N. Speechley and Mark A. Ferro and Mary B. Connolly and Philippe Major and Anne Gallagher and Salah Almubarak and Simona Hasal and Rajesh Ramachandrannair and Andrea Andrade and Qi Xu and Edward Leung and O. Carter Snead and Mary Lou Smith
DOI: 10.1001/jamanetworkopen.2023.4858
03/2023

A longitudinal cohort study of mediators of health-related quality of life after pediatric epilepsy surgery or medical treatment
Epilepsia
Smith, M.L. and Puka, K. and Speechley, K.N. and Ferro, M.A. and Connolly, M.B. and Major, P. and Gallagher, A. and Almubarak, S. and Hasal, S. and Ramachandrannair, R. and Andrade, A. and Xu, Q. and Leung, E. and Snead, O.C. and Widjaja, E.
DOI: 10.1111/epi.17660
2023

Understanding Attributes that Influence Physician and Caregiver Decisions About Neurotechnology for Pediatric Drug-Resistant Epilepsy: A Formative Qualitative Study to Support the Development of a Discrete Choice Experiment
Patient
Apantaku, G. and Aguiar, M. and Kaal, K.J. and McDonald, P.J. and Connolly, M.B. and Hrincu, V. and Illes, J. and Harrison, M.
DOI: 10.1007/s40271-021-00544-w
2022

Clinician preferences for neurotechnologies in pediatric drug-resistant epilepsy: A discrete choice experiment
Epilepsia
Apantaku, G.O. and McDonald, P.J. and Aguiar, M. and Cabrera, L.Y. and Chiong, W. and Connolly, M.B. and Hrincu, V. and Ibrahim, G.M. and Kaal, K.J. and Lawson, A. and Naftel, R. and Racine, E. and Safari, A. and Harrison, M. and Illes, J.
DOI: 10.1111/epi.17328
2022

Targeted Whole Exome Sequencing in Children With Early-Onset Epilepsy: Parent Experiences
Journal of Child Neurology
Alam, A. and Parfyonov, M. and Huang, C.Y. and Gill, I. and Connolly, M.B. and Illes, J.
DOI: 10.1177/08830738221113901
2022

Effect of Training on Visual Identification of High Frequency Oscillations—A Delphi-Style Intervention
Frontiers in Neurology
Spring, A.M. and Pittman, D.J. and Rizwan, A. and Aghakhani, Y. and Jirsch, J. and Connolly, M. and Wiebe, S. and Appendino, J.P. and Datta, A. and Steve, T. and Pillay, N. and Javidan, M. and Scantlebury, M. and Hrazdil, C. and Josephson, C.B. and Boelman, C. and Gross, D. and Singh, S. and Bello-Espinosa, L. and Huh, L. and Jetté, N. and Federico, P.
DOI: 10.3389/fneur.2022.794668
2022

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions
Epilepsia
Hirsch, E. and French, J. and Scheffer, I.E. and Bogacz, A. and Alsaadi, T. and Sperling, M.R. and Abdulla, F. and Zuberi, S.M. and Trinka, E. and Specchio, N. and Somerville, E. and Samia, P. and Riney, K. and Nabbout, R. and Jain, S. and Wilmshurst, J.M. and Auvin, S. and Wiebe, S. and Perucca, E. and Moshé, S. and Tinuper, P. and Wirrell, E.C. and Adikaibe, D.B. and Al Baradi, R. and Andrade, D. and Bast, T. and Beydoun, A. and Bien, C. and Caraballo, R. and Carolina Coan, A. and Connolly, M. and Dunne, J. and Haut, S. and Jansen, F. and Jobst, B. and Kalviainen, R. and Kakooza, A. and Kato, M. and Knupp, K. and Kochen, S. and Lagae, L. and Carlos Mayor, L. and Okujava, N. and Radakishnan, K. and Roulet-Perez, E. and Rios, L. and Sadleir, L. and Juan-Orta, D.S. and Serratosa, J. and Shellhaas, R. and Tsai, M.-H. and Udani, V. and Yue-Hua Zhang,, H. and Zhou., D.
DOI: 10.1111/epi.17236
2022

Adults with tuberous sclerosis complex: A distinct patient population
Epilepsia
Bachour, K. and House, A.A. and Andrade, D.M. and Connolly, M. and Debicki, D.B. and Desbiens, R. and Fantaneanu, T.A. and Kyriakopoulos, P. and Lattouf, J.-B. and Suller-Marti, A. and Marques, P. and Keezer, M.R.
DOI: 10.1111/epi.17159
2022

Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study
Epilepsia
Fallah, A. and Lewis, E. and Ibrahim, G.M. and Kola, O. and Tseng, C.-H. and Harris, W.B. and Chen, J.-S. and Lin, K.-M. and Cai, L.-X. and Liu, Q.-Z. and Lin, J.-L. and Zhou, W.-J. and Mathern, G.W. and Smyth, M.D. and O'Neill, B.R. and Dudley, R.W.R. and Ragheb, J. and Bhatia, S. and Delev, D. and Ramantani, G. and Zentner, J. and Wang, A.C. and Dorfer, C. and Feucht, M. and Czech, T. and Bollo, R.J. and Issabekov, G. and Zhu, H. and Connolly, M. and Steinbok, P. and Zhang, J.-G. and Zhang, K. and Hidalgo, E.T. and Weiner, H.L. and Wong-Kisiel, L. and Lapalme-Remis, S. and Tripathi, M. and Sarat Chandra, P. and Hader, W. and Wang, F.-P. and Yao, Y. and Champagne, P.-O. and Brunette-Clément, T. and Guo, Q. and Li, S.-C. and Budke, M. and Pérez-Jiménez, M.A. and Raftopoulos, C. and Finet, P. and Michel, P. and Schaller, K. and Stienen, M.N. and Baro, V. and Cantillano Malone, C. and Pociecha, J. and Chamorro, N. and Muro, V.L. and von Lehe, M. and Vieker, S. and Oluigbo, C. and Gaillard, W.D. and Al-Khateeb, M. and Al Otaibi, F. and Krayenbühl, N. and Bolton, J. and Pearl, P.L. and Weil, A.G.
DOI: 10.1111/epi.17021
2021

Youth Weigh In: Views on Advanced Neurotechnology for Drug-Resistant Epilepsy
Journal of Child Neurology
Udwadia, F.R. and McDonald, P.J. and Connolly, M.B. and Hrincu, V. and Illes, J.
DOI: 10.1177/0883073820957810
2021

Rapid Implementation of Virtual Health in a Pediatric Neurology Practice during COVID-19
Canadian Journal of Neurological Sciences
Lee, J. and Schrader, D. and Boelman, C. and Huh, L. and Connolly, M.B.
DOI: 10.1017/cjn.2020.241
2021

Choice and Trade-offs: Parent Decision Making for Neurotechnologies for Pediatric Drug-Resistant Epilepsy
Journal of Child Neurology
Hrincu, V. and McDonald, P.J. and Connolly, M.B. and Harrison, M.J. and Ibrahim, G.M. and Naftel, R.P. and Chiong, W. and Alam, A. and Ribary, U. and Illes, J.
DOI: 10.1177/08830738211015010
2021

Cognitive outcome in children with infantile spasms using a standardized treatment protocol. A five-year longitudinal study
Seizure
Bitton, J.Y. and Desnous, B. and Sauerwein, H.C. and Connolly, M. and Weiss, S.K. and Donner, E.J. and Whiting, S. and Mohamed, I.S. and Wirrell, E.C. and Ronen, G.M. and Lortie, A.
DOI: 10.1016/j.seizure.2021.04.027
2021

Novel Neurotechnological Interventions for Pediatric Drug-Resistant Epilepsy: Physician Perspectives
Journal of Child Neurology
McDonald, P.J. and Hrincu, V. and Connolly, M.B. and Harrison, M.J. and Ibrahim, G.M. and Naftel, R.P. and Chiong, W. and Udwadia, F. and Illes, J.
DOI: 10.1177/0883073820966935
2021

SETD1B -associated neurodevelopmental disorder
Journal of Medical Genetics
Roston, A. and Evans, D. and Gill, H. and McKinnon, M. and Isidor, B. and Cogné, B. and Mwenifumbo, J. and Van Karnebeek, C. and An, J. and Jones, S.J.M. and Farrer, M. and Demos, M. and Connolly, M. and Gibson, W.T.
DOI: 10.1136/jmedgenet-2019-106756
2021

Longitudinal changes in emotional functioning following pediatric resective epilepsy surgery: 2-Year follow-up
Epilepsy and Behavior
Phillips, N.L. and Widjaja, E. and Speechley, K. and Ferro, M. and Connolly, M. and Major, P. and Gallagher, A. and Ramachandrannair, R. and Almubarak, S. and Hasal, S. and Andrade, A. and Xu, Q. and Leung, E. and Snead, O.C. and Smith, M.L.
DOI: 10.1016/j.yebeh.2020.107585
2021

Seizure action plans in the pediatric population with epilepsy: Uptake, determinants, and parental interest in a mobile application
Epilepsy and Behavior
Chiu, M. and Peinhof, S. and De Guzman, C. and Borhani, M. and Siu, C. and Kuzeljevic, B. and Schrader, D. and Huh, L. and Connolly, M.B.
DOI: 10.1016/j.yebeh.2021.107860
2021

Ethically Problematic Medical Device Representation.
The American journal of bioethics : AJOB
Illes J and McDonald PJ and Lau C and Hrincu VM and Connolly MB
DOI: 10.1080/15265161.2020.1782643
PubMed: 32757913
08/2020

Erratum: Pathophysiology of and therapeutic options for a GABRA1 variant linked to epileptic encephalopathy (Molecular Brain (2019) 12 (92) DOI: 10.1186/s13041-019-0513-9)
Molecular Brain
Bai, Y.-F. and Chiu, M. and Chan, E.S. and Axerio-Cilies, P. and Lu, J. and Huh, L. and Connolly, M.B. and Guella, I. and Farrer, M.J. and Xu, Z.-Q.D. and Liu, L. and Demos, M. and Wang, Y.T.
DOI: 10.1186/s13041-020-00593-6
2020

Seizure freedom improves health-related quality of life after epilepsy surgery in children
Developmental Medicine and Child Neurology
Jain, P. and Smith, M.L. and Speechley, K. and Ferro, M. and Connolly, M. and Ramachandrannair, R. and Almubarak, S. and Andrade, A. and Widjaja, E.
DOI: 10.1111/dmcn.14390
2020

Exome sequencing identified a de novo mutation of PURA gene in a patient with familial Xp22.31 microduplication
European Journal of Medical Genetics
Ying Qiao and Hani Bagheri and Flamingo Tang and Chansonette Badduke and Sally Martell and Suzanne M.E. Lewis and Wendy Robinson and Mary B. Connolly and Laura Arbour and Evica Rajcan-Separovic
DOI: 10.1016/j.ejmg.2018.06.010
02/2019

CYP2D6 as a treatment decision aid for ER-positive non-metastatic breast cancer patients: a systematic review with accompanying clinical practice guidelines
Breast Cancer Research and Treatment
Drögemöller, B.I. and Wright, G.E.B. and Shih, J. and Monzon, J.G. and Gelmon, K.A. and Ross, C.J.D. and Amstutz, U. and Carleton, B.C. and Chang, W.C. and Connolly, M.B. and Dionne, F. and Groeneweg, G. and Loucks, C.M. and MacLeod, S.M. and Pritchard, S. and Rassekh, S.R. and Sanatani, S. and Tanoshima, R. and Virani, S.A. and Monzon, J.G. and Bhavsar, A.P. and Rieder, M.J. and Shear, N.H. and Liu, G. and Khayat, P. and Bernstein, D. and Lesko, L.J. and Aminkeng, F.
DOI: 10.1007/s10549-018-5027-0
2019

Position Statement on the Use of Medical Cannabis for the Treatment of Epilepsy in Canada,Énoncé de position quant à l'utilisation du cannabis médical dans le traitement de l'épilepsie
Canadian Journal of Neurological Sciences
Appendino, J.P. and Boelman, C. and Brna, P.M. and Burneo, J.G. and Claassen, C.S. and Connolly, M.B. and De Guzman, M.V.T. and Federico, P. and Floyd, D. and Huntsman, R.J. and Javidan, M. and Jette, N. and Jurasek, L.L. and Keezer, M.R. and Lau, J.C. and McCoy, B. and McLachlan, R.S. and Ng, M.C. and Nguyen, D.K. and Reid, A.Y. and Rho, J.M. and Snead, O.C. and Téllez-Zenteno, J.F. and Wang, L. and Zak, M.M.
DOI: 10.1017/cjn.2019.282
2019

mTOR Inhibitors as a New Therapeutic Strategy in Treatment Resistant Epilepsy in Hemimegalencephaly: A Case Report
Journal of Child Neurology
Xu, Q. and Uliel-Sibony, S. and Dunham, C. and Sarnat, H. and Flores-Sarnat, L. and Brunga, L. and Davidson, S. and Lo, W. and Shlien, A. and Connolly, M. and Boelman, C. and Datta, A.
DOI: 10.1177/0883073818813238
2019

Diagnostic yield and treatment impact of targeted exome sequencing in early-onset epilepsy
Frontiers in Neurology
Demos, M. and Guella, I. and DeGuzman, C. and McKenzie, M.B. and Buerki, S.E. and Evans, D.M. and Toyota, E.B. and Boelman, C. and Huh, L.L. and Datta, A. and Michoulas, A. and Selby, K. and Bjornson, B.H. and Horvath, G. and Lopez-Rangel, E. and Van Karnebeek, C.D.M. and Salvarinova, R. and Slade, E. and Eydoux, P. and Adam, S. and Van Allen, M.I. and Nelson, T.N. and Bolbocean, C. and Connolly, M.B. and Farrer, M.J.
DOI: 10.3389/fneur.2019.00434
2019

Atypical cerebral palsy: genomics analysis enables precision medicine
Genetics in Medicine
Matthews, A.M. and Blydt-Hansen, I. and Al-Jabri, B. and Andersen, J. and Tarailo-Graovac, M. and Price, M. and Selby, K. and Demos, M. and Connolly, M. and Drögemoller, B. and Shyr, C. and Mwenifumbo, J. and Elliott, A.M. and Lee, J. and Ghani, A. and Stöckler, S. and Salvarinova, R. and Vallance, H. and Sinclair, G. and Ross, C.J. and Wasserman, W.W. and McKinnon, M.L. and Horvath, G.A. and Goez, H. and van Karnebeek, C.D.
DOI: 10.1038/s41436-018-0376-y
2019

Assessing an Interactive Online Tool to Support Parents' Genomic Testing Decisions
Journal of Genetic Counseling
Adam, S. and Birch, P.H. and Coe, R.R. and Bansback, N. and Jones, A.L. and Connolly, M.B. and Demos, M.K. and Toyota, E.B. and Farrer, M.J. and Friedman, J.M.
DOI: 10.1007/s10897-018-0281-1
2019

Pathophysiology of and therapeutic options for a GABRA1 variant linked to epileptic encephalopathy
Molecular Brain
Bai, Y.-F. and Chiu, M. and Chan, E.S. and Axerio-Cilies, P. and Lu, J. and Huh, L. and Connolly, M.B. and Guella, I. and Farrer, M.J. and Xu, Z.-Q.D. and Liu, L. and Demos, M. and Wang, Y.T.
DOI: 10.1186/s13041-019-0513-9
2019

Care-related quality of life in caregivers of children with drug-resistant epilepsy
Journal of Neurology
DOI: 10.1007/s00415-018-8979-4
10/2018

Humanized mouse model of Rasmussen’s encephalitis supports the immune-mediated hypothesis
Journal of Clinical Investigation
Hania Kebir and Lionel Carmant and François Fontaine and Kathie Béland and Ciprian M. Bosoi and Nathalie T. Sanon and Jorge I. Alvarez and Sébastien Desgent and Camille L. Pittet and David Hébert and Marie-Josée Langlois and Rose-Marie Rébillard and Dang K. Nguyen and Cécile Cieuta-Walti and Gregory L. Holmes and Howard P. Goodkin and John R. Mytinger and Mary B. Connolly and Alexandre Prat and Elie Haddad
DOI: 10.1172/jci97098
04/2018

MRI and laboratory features and the performance of international criteria in the diagnosis of multiple sclerosis in children and adolescents: a prospective cohort study
The Lancet Child & Adolescent Health
Giulia Fadda and Robert A Brown and Giulia Longoni and Denise A Castro and Julia O'Mahony and Leonard H Verhey and Helen M Branson and Patrick Waters and Amit Bar-Or and Ruth Ann Marrie and E Ann Yeh and Sridar Narayanan and Douglas L Arnold and Brenda Banwell and Katherine Wambera and Mary B Connolly and Jerome Yager and Jean K Mah and Giullaume Sebire and David Callen and Brandon Meaney and Marie-Emmanuelle Dilenge and Anne Lortie and Daniela Pohl and Asif Doja and Sunita Venkateswaran and Simon Levin and E Athen MacDonald and David Meek and Ellen Wood and David Buckley and Mark Awuku and J Burke Baird and Virender Bhan and Rozie Arnaoutelis and Danusha Nandamalavan
DOI: 10.1016/s2352-4642(18)30026-9
03/2018

Improvement of Self-Injury With Dopamine and Serotonin Replacement Therapy in a Patient With a Hemizygous PAK3 Mutation: A New Therapeutic Strategy for Neuropsychiatric Features of an Intellectual Disability Syndrome.
Journal of child neurology
Horvath GA and Tarailo-Graovac M and Bartel T and Race S and Van Allen MI and Blydt-Hansen I and Ross CJ and Wasserman WW and Connolly MB and van Karnebeek CDM
DOI: 10.1177/0883073817740443
PubMed: 29246092
01/2018

MRI and laboratory features and the performance of international criteria in the diagnosis of multiple sclerosis in children and adolescents: a prospective cohort study
The Lancet Child and Adolescent Health
Fadda, G. and Brown, R.A. and Longoni, G. and Castro, D.A. and O'Mahony, J. and Verhey, L.H. and Branson, H.M. and Waters, P. and Bar-Or, A. and Marrie, R.A. and Yeh, E.A. and Narayanan, S. and Arnold, D.L. and Banwell, B. and Wambera, K. and Connolly, M.B. and Yager, J. and Mah, J.K. and Sebire, G. and Callen, D. and Meaney, B. and Dilenge, M.-E. and Lortie, A. and Pohl, D. and Doja, A. and Venkateswaran, S. and Levin, S. and MacDonald, E.A. and Meek, D. and Wood, E. and Buckley, D. and Awuku, M. and Baird, J.B. and Bhan, V. and Arnaoutelis, R. and Nandamalavan, D.
DOI: 10.1016/S2352-4642(18)30026-9
2018

ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology,ILAE-Klassifikation der Epilepsien: Positionspapier der ILAE-Kommission für Klassifikation und Terminologie
Zeitschrift fur Epileptologie
Scheffer, I.E. and Berkovic, S. and Capovilla, G. and Connolly, M.B. and French, J. and Guilhoto, L. and Hirsch, E. and Jain, S. and Mathern, G.W. and Moshé, S.L. and Nordli, D.R. and Perucca, E. and Tomson, T. and Wiebe, S. and Zhang, Y.-H. and Zuberi, S.M.
DOI: 10.1007/s10309-018-0218-6
2018

Humanized mouse model of Rasmussen's encephalitis supports the immune-mediated hypothesis
Journal of Clinical Investigation
Kebir, H. and Carmant, L. and Fontaine, F. and Béland, K. and Bosoi, C.M. and Sanon, N.T. and Alvarez, J.I. and Desgent, S. and Pittet, C.L. and Hébert, D. and Langlois, M.-J. and Rébillard, R.-M. and Nguyen, D.K. and Cieuta-Walti, C. and Holmes, G.L. and Goodkin, H.P. and Mytinger, J.R. and Connolly, M.B. and Prat, A. and Haddad, E.
DOI: 10.1172/JCI97098
2018

Secondary Abnormal CSF Neurotransmitter Metabolite Profiles in a Pediatric Tertiary Care Centre
Canadian Journal of Neurological Sciences
Van Karnebeek, C.D.M. and Dunbar, M. and Egri, C. and Sayson, B. and Milea, J. and Stockler-Ipsiroglu, S. and Huh, L. and Connolly, M.B. and Horvath, G.A.
DOI: 10.1017/cjn.2017.271
2018

An Infant With Epilepsy and Recurrent Hemiplegia due to Compound Heterozygous Variants in ATP1A2.
Pediatric neurology
Wilbur C and Buerki SE and Guella I and Toyota EB and Evans DM and McKenzie MB and Datta A and Michoulas A and Adam S and Van Allen MI and Nelson TN and Farrer MJ and Connolly MB and Demos M
DOI: 10.1016/j.pediatrneurol.2017.06.003
PubMed: 28811059
10/2017

De Novo Mutations in YWHAG Cause Early-Onset Epilepsy.
American journal of human genetics
Guella I and McKenzie MB and Evans DM and Buerki SE and Toyota EB and Van Allen MI and Epilepsy Genomics Study and Suri M and Elmslie F and Farrer MJ
DOI: 10.1016/j.ajhg.2017.07.004
PubMed: 28777935
08/2017

Clinical Experience With Perampanel for Refractory Pediatric Epilepsy in One Canadian Center.
Journal of child neurology
Datta AN and Xu Q and Sachedina S and Boelman C and Huh L and Connolly MB
DOI: 10.1177/0883073817709195
PubMed: 28511603
08/2017

Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy.
American journal of human genetics
Lehman A and Thouta S and Mancini GMS and Naidu S and van Slegtenhorst M and McWalter K and Person R and Mwenifumbo J and Salvarinova R and CAUSES Study and EPGEN Study and Guella I and Claydon T
DOI: 10.1016/j.ajhg.2017.05.016
PubMed: 28669405
07/2017

Child- and parent-reported quality of life trajectories in children with epilepsy: A prospective cohort study.
Epilepsia
Ferro MA and Avery L and Fayed N and Streiner DL and Cunningham CE and Boyle MH and Lach L and Glidden G and Rosenbaum PL and Ronen GM and QUALITÉ group
DOI: 10.1111/epi.13774
PubMed: 28485850
07/2017

The relationship between d-beta-hydroxybutyrate blood concentrations and seizure control in children treated with the ketogenic diet for medically intractable epilepsy
Epilepsia Open
Jeffrey R. Buchhalter and Sabrina D'Alfonso and Mary Connolly and Ernest Fung and Aspasia Michoulas and David Sinasac and Rachel Singer and Jacklyn Smith and Narender Singh and Jong M. Rho
DOI: 10.1002/epi4.12058
05/2017

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology.
Epilepsia
Scheffer IE and Berkovic S and Capovilla G and Connolly MB and French J and Guilhoto L and Hirsch E and Jain S and Mathern GW and Moshé SL and Nordli DR and Perucca E and Tomson T and Zuberi SM
DOI: 10.1111/epi.13709
PubMed: 28276062
04/2017

Clinical, imaging, and immunohistochemical characteristics of focal cortical dysplasia Type II extratemporal epilepsies in children: analyses of an institutional case series.
Journal of neurosurgery. Pediatrics
Knerlich-Lukoschus F and Connolly MB and Hendson G and Steinbok P and Dunham C
DOI: 10.3171/2016.8.peds1686
PubMed: 27885945
02/2017

Manifestations of Tuberous Sclerosis Complex: The Experience of a Provincial Clinic.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Wilbur C and Sanguansermsri C and Chable H and Anghelina M and Peinhof S and Anderson K and Steinbok P and Singhal A and Datta A and Connolly MB
DOI: 10.1017/cjn.2016.311
PubMed: 28004629
01/2017

Diagnostic yield and treatment impact of targeted exome sequencing in early-onset epilepsy
bioRxiv
Demos, M. and Guella, I. and McKenzie, M.B. and Buerki, S.E. and Evans, D.M. and Toyota, E.B. and Boelman, C. and Huh, L.L. and Datta, A. and Michoulas, A. and Selby, K. and Bjornson, B.H. and Horvath, G. and Lopez-Rangel, E. and van Karnebeek, C.D.M. and Salvarinova, R. and Slade, E. and Eydoux, P. and Adam, S. and van Allen, M.I. and Nelson, T.N. and Bolbocean, C. and Connolly, M.B. and Farrer, M.J.
DOI: 10.1101/139329
2017

Clinical, imaging, and immunohistochemical characteristics of focal cortical dysplasia Type II extratemporal epilepsies in children: Analyses of an institutional case series
Journal of Neurosurgery: Pediatrics
Knerlich-Lukoschus, F. and Connolly, M.B. and Hendson, G. and Steinbok, P. and Dunham, C.
DOI: 10.3171/2016.8.PEDS1686
2017

De novo FGF12 mutation in 2 patients with neonatal-onset epilepsy.
Neurology. Genetics
Guella I and Huh L and McKenzie MB and Toyota EB and Bebin EM and Thompson ML and Cooper GM and Evans DM and Buerki SE and Adam S and Van Allen MI and Nelson TN and Connolly MB and Farrer MJ and Demos M
DOI: 10.1212/nxg.0000000000000120
PubMed: 27872899
12/2016

Dravet Syndrome: Diagnosis and Long-Term Course.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Connolly MB
DOI: 10.1017/cjn.2016.243
PubMed: 27264139
06/2016

Correlates of health-related quality of life in children with drug resistant epilepsy
Epilepsia
Lauryn Conway and Mary Lou Smith and Mark A. Ferro and Kathy N. Speechley and Mary B. Connoly and O. Carter Snead and Elysa Widjaja and the PEPSQOL Study Team
DOI: 10.1111/epi.13441
06/2016

Exome Sequencing and the Management of Neurometabolic Disorders.
The New England journal of medicine
Tarailo-Graovac M and Shyr C and Ross CJ and Horvath GA and Salvarinova R and Ye XC and Zhang LH and Bhavsar AP and Lee JJ and Drögemöller BI and Abdelsayed M and Alfadhel M and van Karnebeek CD
DOI: 10.1056/nejmoa1515792
PubMed: 27276562
06/2016

Exome sequencing and the management of neurometabolic disorders
New England Journal of Medicine
Tarailo-Graovac, M. and Shyr, C. and Ross, C.J. and Horvath, G.A. and Salvarinova, R. and Ye, X.C. and Zhang, L.-H. and Bhavsar, A.P. and Lee, J.J.Y. and Drögemöller, B.I. and Abdelsayed, M. and Alfadhel, M. and Armstrong, L. and Baumgartner, M.R. and Burda, P. and Connolly, M.B. and Cameron, J. and Demos, M. and Dewan, T. and Dionne, J. and Evans, A.M. and Friedman, J.M. and Garber, I. and Lewis, S. and Ling, J. and Mandal, R. and Mattman, A. and McKinnon, M. and Michoulas, A. and Metzger, D. and Ogunbayo, O.A. and Rakic, B. and Rozmus, J. and Ruben, P. and Sayson, B. and Santra, S. and Schultz, K.R. and Selby, K. and Shekel, P. and Sirrs, S. and Skrypnyk, C. and Superti-Furga, A. and Turvey, S.E. and Van Allen, M.I. and Wishart, D. and Wu, J. and Wu, J. and Zafeiriou, D. and Kluijtmans, L. and Wevers, R.A. and Eydoux, P. and Lehman, A.M. and Vallance, H. and Stockler-Ipsiroglu, S. and Sinclair, G. and Wasserman, W.W. and Van Karnebeek, C.D.
DOI: 10.1056/NEJMoa1515792
2016

De novo FGF12 mutation in 2 patients with neonatal-onset epilepsy
Neurology: Genetics
Guella, I. and Huh, L. and McKenzie, M.B. and Toyota, E.B. and Martina Bebin, E. and Thompson, M.L. and Cooper, G.M. and Evans, D.M. and Buerki, S.E. and Adam, S. and Van Allen, M.I. and Nelson, T.N. and Connolly, M.B. and Farrer, M.J. and Demos, M.
DOI: 10.1212/NXG.0000000000000120
2016

Resective Epilepsy Surgery for Tuberous Sclerosis in Children: Determining Predictors of Seizure Outcomes in a Multicenter Retrospective Cohort Study.
Neurosurgery
Fallah A and Rodgers SD and Weil AG and Vadera S and Mansouri A and Connolly MB and Major P and Ma T and Devinsky O and Weiner HL and Gonzalez-Martinez JA and Bingaman WE and Najm I and Rutka JT
DOI: 10.1227/neu.0000000000000875
PubMed: 26120800
10/2015

Recovery From Central Nervous System Acute Demyelination in Children.
Pediatrics
O'Mahony J and Marrie RA and Laporte A and Yeh EA and Bar-Or A and Phan C and Buckley D and Callen D and Connolly MB and Pohl D and Dilenge ME and Bernard G and Lortie A and Lowry N and Banwell B
DOI: 10.1542/peds.2015-0028
PubMed: 26034241
07/2015

Tick paralysis: Presentation as a pure cerebellar syndrome
Journal of Pediatric Neurology
Raed Alroughani and Jonathan Guilfoyle and Mary Connolly
DOI: 10.1055/s-0035-1557486
07/2015

Does treatment have an impact on incidence and risk factors for autism spectrum disorders in children with infantile spasms?
Epilepsia
Bitton JY and Demos M and Elkouby K and Connolly M and Weiss SK and Donner EJ and Whiting S and Ronen GM and Bello-Espinosa L and Wirrell EC and Mohamed IS and Dooley JM and Carmant L
DOI: 10.1111/epi.12997
PubMed: 25944453
06/2015

The "vagal ansa": a source of complication in vagus nerve stimulation.
Journal of neurosurgery. Pediatrics
Gopalakrishnan CV and Kestle JR and Connolly MB
DOI: 10.3171/2014.10.peds14259
PubMed: 25700120
05/2015

Children's perspective of quality of life in epilepsy
Neurology
N. Fayed and A. M. Davis and D. L. Streiner and P. L. Rosenbaum and C. E. Cunningham and L. M. Lach and M. H. Boyle and G. M. Ronen and On behalf of the QUALITE Study Group
DOI: 10.1212/wnl.0000000000001536
04/2015

The importance of cerebral magnetic resonance imaging in evaluation of neonatal seizures.
Developmental medicine and child neurology
Buerki SE and Connolly MB
DOI: 10.1111/dmcn.12640
PubMed: 25407829
03/2015

Resective Epilepsy Surgery for Tuberous Sclerosis in Children: Determining Predictors of Seizure Outcomes in a Multicenter Retrospective Cohort Study
Neurosurgery
Fallah, A. and Rodgers, S.D. and Weil, A.G. and Vadera, S. and Mansouri, A. and Connolly, M.B. and Major, P. and Ma, T. and Devinsky, O. and Weiner, H.L. and Gonzalez-Martinez, J.A. and Bingaman, W.E. and Najm, I. and Gupta, A. and Ragheb, J. and Bhatia, S. and Steinbok, P. and Witiw, C.D. and Widjaja, E. and Snead, O.C. and Rutka, J.T.
DOI: 10.1227/NEU.0000000000000875
2015

The "vagal ansa": A source of complication in vagus nerve stimulation
Journal of Neurosurgery: Pediatrics
Gopalakrishnan, C.V. and Kestle, J.R.W. and Connolly, M.B.
DOI: 10.3171/2014.10.PEDS14259
2015

Diagnostic value of a multidisciplinary clinic for intellectual disability.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
van Karnebeek C and Murphy T and Giannasi W and Thomas M and Connolly M and Stockler-Ipsiroglu S
PubMed: 24718818
05/2014

Clinical and magnetic resonance imaging (MRI) distinctions between tumefactive demyelination and brain tumors in children.
Journal of child neurology
Yiu EM and Laughlin S and Verhey LH and Banwell BL and Canadian Pediatric Demyelinating Disease Network
DOI: 10.1177/0883073813500713
PubMed: 24092896
05/2014

Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions.
Epilepsia
Amstutz U and Shear NH and Rieder MJ and Hwang S and Fung V and Nakamura H and Connolly MB and Ito S and Carleton BC and CPNDS clinical recommendation group
DOI: 10.1111/epi.12564
PubMed: 24597466
04/2014

Pyridoxine responsiveness in novel mutations of the PNPO gene.
Neurology
Plecko B and Paul K and Mills P and Clayton P and Paschke E and Maier O and Hasselmann O and Schmiedel G and Kanz S and Connolly M and Wolf N and Struys E and Stockler S and Abela L and Hofer D
DOI: 10.1212/wnl.0000000000000344
PubMed: 24658933
04/2014

Classifying Epileptic Seizures and the Epilepsies
Epilepsy
Valeria M. Muro and Mary B. Connolly
DOI: 10.1002/9781118456989.ch2
01/2014

Outcomes trajectories in children with epilepsy: hypotheses and methodology of a Canadian longitudinal observational study.
Pediatric neurology
Ronen GM and Streiner DL and Boyle MH and Cunningham CE and Lach L and Verhey LH and Fayed N and Chen K and Rosenbaum PL and QUALITÉ Group and Connolly M and Bello-Espinosa LE and Carmant L
DOI: 10.1016/j.pediatrneurol.2013.08.024
PubMed: 24370172
01/2014

Pyridoxine responsiveness in novel mutations of the PNPO gene
Neurology
Plecko, B. and Paul, K. and Mills, P. and Clayton, P. and Paschke, E. and Maier, O. and Hasselmann, O. and Schmiedel, G. and Kanz, S. and Connolly, M. and Wolf, N. and Struys, E. and Stockler, S. and Abela, L. and Hofer, D.
DOI: 10.1212/WNL.0000000000000344
2014

Diagnostic Value of a Multidisciplinary Clinic for Intellectual Disability
Canadian Journal of Neurological Sciences
Van Karnebeek, C. and Murphy, T. and Giannasi, W. and Thomas, M. and Connolly, M. and Stockler-Ipsiroglu, S.
DOI: 10.1017/S0317167100017273
2014

Acute flaccid paralysis in a child infected with enterovirus D68: A case report
British Columbia Medical Journal
Sherwood, M.D. and Gantt, S. and Connolly, M. and Dobson, S.
2014

MRI findings in infants with infantile spasms after neonatal hypoxic-ischemic encephalopathy.
Pediatric neurology
Gano D and Sargent MA and Miller SP and Connolly MB and Wong P and Glass HC and Poskitt KJ and Chau V
DOI: 10.1016/j.pediatrneurol.2013.08.007
PubMed: 24095571
12/2013

Hippocampal Malrotation and Temporal Lobe Epilepsy: What is the Relationship?
The Canadian Journal of Neurological Sciences
Mary B. Connolly
DOI: 10.1017/s0317167100014839
09/2013

A case report of obsessive-compulsive disorder following acute disseminated encephalomyelitis.
Pediatrics
Muir KE and McKenney KS and Connolly MB and Stewart SE
DOI: 10.1542/peds.2012-2876
PubMed: 23918895
09/2013

Hippocampal malrotation and temporal lobe epilepsy: what is the relationship?
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Connolly MB
PubMed: 23968933
09/2013

Status epilepticus amauroticus and posterior reversible encephalopathy syndrome in children.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
Muro VL and Yip S and Huh L and Connolly MB
DOI: 10.1097/wnp.0b013e31829de004
PubMed: 23912571
08/2013

Masquerades of acquired demyelination in children: experiences of a national demyelinating disease program.
Journal of child neurology
O'Mahony J and Bar-Or A and Arnold DL and Sadovnick AD and Marrie RA and Banwell B and Canadian Pediatric Demyelinating Disease Network
DOI: 10.1177/0883073812443006
PubMed: 22573735
02/2013

A condensed performance-validation strategy for multiplex detection kits used in studies of human clinical samples
Journal of Immunological Methods
Chahrazed Belabani and Sathyanath Rajasekharan and Viviane Poupon and Trina Johnson and Amit Bar-Or
DOI: 10.1016/j.jim.2012.08.002
01/2013

Hippocampal malrotation and temporal lobe epilepsy: What is the relationship?
Canadian Journal of Neurological Sciences
Connolly, M.B.
DOI: 10.1017/S0317167100014839
PubMed: 23968933
2013

Status epilepticus amauroticus and posterior reversible encephalopathy syndrome in children
Journal of Clinical Neurophysiology
Muro, V.L. and Yip, S. and Huh, L. and Connolly, M.B.
DOI: 10.1097/WNP.0b013e31829de004
2013

Epilepsy Surgery in Childhood
The Canadian Journal of Neurological Sciences
Valeria L. Muro and Mary B. Connolly
DOI: 10.1017/s0317167100018163
11/2012

Discontinuation of antiepileptic drugs after successful epilepsy surgery. a Canadian survey.
Epilepsy research
Téllez-Zenteno JF and Ronquillo LH and Jette N and Burneo JG and Nguyen DK and Donner EJ and Sadler M and Javidan M M and Gross DW and Wiebe S and Canadian Epilepsy Surgery Study Group
DOI: 10.1016/j.eplepsyres.2012.04.018
PubMed: 22595484
11/2012

Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials.
Molecular genetics and metabolism
van Karnebeek CD and Hartmann H and Jaggumantri S and Bok LA and Cheng B and Connolly M and Coughlin CR and Das AM and Gospe SM and Jakobs C and van der Lee JH and Stockler S
DOI: 10.1016/j.ymgme.2012.09.006
PubMed: 23022070
11/2012

2010 McDonald criteria for diagnosing pediatric multiple sclerosis
Annals of Neurology
Yair Sadaka and Leonard H. Verhey and Manohar M. Shroff and Helen M. Branson and Douglas L. Arnold and Sridar Narayanan and John G. Sled and Amit Bar-Or and A. Dessa Sadovnick and Melissa McGowan and Ruth Ann Marrie and Brenda Banwell and on behalf of the Canadian Pediatric Demyelinating Disease Network
DOI: 10.1002/ana.23575
08/2012

Benign myoclonic epilepsy of infancy
Pediatric Epilepsy
08/2012

Profound neonatal hypoglycemia and lactic acidosis caused by pyridoxine-dependent epilepsy.
Pediatrics
Mercimek-Mahmutoglu S and Horvath GA and Coulter-Mackie M and Nelson T and Waters PJ and Sargent M and Struys E and Jakobs C and Stockler-Ipsiroglu S and Connolly MB
DOI: 10.1542/peds.2011-0123
PubMed: 22529283
05/2012

Systematic review and case series of neuropsychological functioning after epilepsy surgery in children with dysembryoplastic neuroepithelial tumors (DNET)
Epilepsy & Behavior
Taryn B. Fay-McClymont and Marianne Hrabok and Elisabeth M.S. Sherman and Walter J. Hader and Mary B. Connolly and Sare Akdag and Ismail S. Mohamed and Samuel Wiebe
DOI: 10.1016/j.yebeh.2011.12.011
04/2012

Epilepsy surgery in childhood
Canadian Journal of Neurological Sciences
Muro, V.L. and Connolly, M.B.
2012

Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study.
The Lancet. Neurology
Banwell B and Bar-Or A and Arnold DL and Sadovnick D and Narayanan S and McGowan M and O'Mahony J and Magalhaes S and Hanwell H and Vieth R and Tellier R and Vincent T and Disanto G and Marrie RA
DOI: 10.1016/s1474-4422(11)70045-x
PubMed: 21459044
05/2011

HLA-DRB1 confers increased risk of pediatric-onset MS in children with acquired demyelination.
Neurology
Disanto G and Magalhaes S and Handel AE and Morrison KM and Sadovnick AD and Ebers GC and Banwell B and Bar-Or A and Canadian Pediatric Demyelinating Disease Network
DOI: 10.1212/wnl.0b013e31820ee1cd
PubMed: 21288988
03/2011

Cerebral sinus thrombosis following IV immunoglobulin therapy of immune thrombocytopenia purpura
Pediatric Blood & Cancer
Arwa Z. Al-Riyami and James Lee and Mary Connolly and Evan Shereck
DOI: 10.1002/pbc.22968
03/2011

Mitochondrial DNA haplogroups and mutations in children with acquired central demyelination.
Neurology
Venkateswaran S and Zheng K and Sacchetti M and Gagne D and Arnold DL and Sadovnick AD and Scherer SW and Banwell B and Bar-Or A and Simon DK and Canadian Pediatric Demyelinating Disease Network
DOI: 10.1212/wnl.0b013e31820ee1bb
PubMed: 21288980
03/2011

Electroclinical features of absence seizures in sleep
Epilepsy Research
Lynette G. Sadleir and Kevin Farrell and Sherry Smith and Mary B. Connolly and Ingrid E. Scheffer
DOI: 10.1016/j.eplepsyres.2010.12.009
02/2011

Cerebrovasculopathy in NF1 associated with ocular and scalp defects.
American journal of medical genetics. Part A
Smith M and Heran MK and Connolly MB and Heran HK and Friedman JM and Jett K and Lyons CJ and Steinbok P and Armstrong L
DOI: 10.1002/ajmg.a.33788
PubMed: 21271658
02/2011

Landau-Kleffner syndrome: a rare auditory processing disorder series of cases and review of the literature.
International journal of pediatric otorhinolaryngology
Fandiño M and Connolly M and Usher L and Palm S and Kozak FK
DOI: 10.1016/j.ijporl.2010.10.001
PubMed: 21074868
01/2011

Epilepsy with occipital features in children: factors predicting seizure outcome and neuroimaging abnormalities.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Schrader D and Shukla R and Gatrill R and Farrell K and Connolly M
DOI: 10.1016/j.ejpn.2010.08.005
PubMed: 20829080
01/2011

Improving the management of epilepsy in children
British Columbia Medical Journal
Farrell Dr., K. and Connolly Dr., M.
2011

Electrocorticography and seizure outcomes in children with lesional epilepsy
Child's Nervous System
Gelinas, J.N. and Battison, A.W. and Smith, S. and Connolly, M.B. and Steinbok, P.
DOI: 10.1007/s00381-010-1279-7
2011

Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: A prospective national cohort study
The Lancet Neurology
Banwell, B. and Bar-Or, A. and Arnold, D.L. and Sadovnick, D. and Narayanan, S. and McGowan, M. and O'Mahony, J. and Magalhaes, S. and Hanwell, H. and Vieth, R. and Tellier, R. and Vincent, T. and Disanto, G. and Ebers, G. and Wambera, K. and Connolly, M.B. and Yager, J. and Mah, J.K. and Booth, F. and Sebire, G. and Callen, D. and Meaney, B. and Dilenge, M.-E. and Lortie, A. and Pohl, D. and Doja, A. and Venketaswaran, S. and Levin, S. and MacDonald, E.A. and Meek, D. and Wood, E. and Lowry, N. and Buckley, D. and Yim, C. and Awuku, M. and Cooper, P. and Grand'Maison, F. and Baird, J.B. and Bhan, V. and Marrie, R.A.
DOI: 10.1016/S1474-4422(11)70045-X
2011

Pyridoxine dependent epilepsy and antiquitin deficiency. Clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up
Molecular Genetics and Metabolism
Stockler, S. and Plecko, B. and Gospe, S.M. and Coulter-Mackie, M. and Connolly, M. and van Karnebeek, C. and Mercimek-Mahmutoglu, S. and Hartmann, H. and Scharer, G. and Struijs, E. and Tein, I. and Jakobs, C. and Clayton, P. and Van Hove, J.L.K.
DOI: 10.1016/j.ymgme.2011.05.014
2011

Approach to a child with a first afebrile seizure
British Columbia Medical Journal
Michoulas, A. and Farrell, K. and Connolly, M.
2011

Approach to a child with a first afebrile seizure
BC Medical Journal
2011

Treatment of intractable epilepsy in a female with SLC6A8 deficiency.
Molecular genetics and metabolism
Mercimek-Mahmutoglu S and Connolly MB and Poskitt KJ and Horvath GA and Lowry N and Salomons GS and Casey B and Sinclair G and Davis C and Jakobs C and Stockler-Ipsiroglu S
DOI: 10.1016/j.ymgme.2010.08.016
PubMed: 20846889
12/2010

Parents report more ADHD symptoms than do teachers in children with epilepsy
Epilepsy & Behavior
Elisabeth M.S. Sherman and Brian L. Brooks and Sare Akdag and Mary B. Connolly and Samuel Wiebe
DOI: 10.1016/j.yebeh.2010.08.015
11/2010

Red reflex mimicking lens subluxation in a child undergoing orthokeratology.
Eye
Wiwatwongwana A and Connolly MB and Lyons CJ
DOI: 10.1038/eye.2009.46
PubMed: 19300465
01/2010

Cingulate lesions presenting with epileptic spasms.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
Schrader D and Langill L and Singhal A and Steinbok P and Connolly MB
DOI: 10.1097/wnp.0b013e3181baaacf
PubMed: 19752743
10/2009

Epilepsy and memory dysfunction.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Connolly MB
PubMed: 19760900
08/2009

Automatisms in Absence Seizures in Children With Idiopathic Generalized Epilepsy
Archives of Neurology
Lynette G. Sadleir and Ingrid E. Scheffer and Sherry Smith and Mary B. Connolly and Kevin Farrell
DOI: 10.1001/archneurol.2009.108
06/2009

Epilepsy surgery in the first 3 years of life: a Canadian survey.
Epilepsia
Steinbok P and Gan PY and Connolly MB and Carmant L and Barry Sinclair D and Rutka J and Griebel R and Aronyk K and Hader W and Ventureyra E and Atkinson J
DOI: 10.1111/j.1528-1167.2008.01992.x
PubMed: 19175388
06/2009

EEG features of absence seizures in idiopathic generalized epilepsy: impact of syndrome, age, and state.
Epilepsia
Sadleir LG and Scheffer IE and Smith S and Carstensen B and Farrell K and Connolly MB
DOI: 10.1111/j.1528-1167.2008.02001.x
PubMed: 19243419
06/2009

Incidence of acquired demyelination of the CNS in Canadian children.
Neurology
Banwell B and Kennedy J and Sadovnick D and Arnold DL and Magalhaes S and Wambera K and Connolly MB and Yager J and Mah JK and Shah N and Sebire G and Meaney B and Dilenge ME and Lortie A and Bar-Or A
DOI: 10.1212/01.wnl.0000339482.84392.bd
PubMed: 19153370
01/2009

Urgent, resective surgery for medically refractory, convulsive status epilepticus.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Schrader DV and Steinbok P and Connolly M
DOI: 10.1016/j.ejpn.2008.01.011
PubMed: 18460420
01/2009

Epilepsy and memory dysfunction
Canadian Journal of Neurological Sciences
Connolly, M.B.
2009

Cingulate lesions presenting with epileptic spasms
Journal of Clinical Neurophysiology
Schrader, D. and Langill, L. and Singhal, A. and Steinbok, P. and Connolly, M.B.
DOI: 10.1097/WNP.0b013e3181baaacf
2009

Factors influencing clinical features of absence seizures.
Epilepsia
Sadleir LG and Scheffer IE and Smith S and Carstensen B and Carlin J and Connolly MB and Farrell K
DOI: 10.1111/j.1528-1167.2008.01708.x
PubMed: 18616552
12/2008

Cranial Neuropathy, Polyneuropathy and Thrombocytopenia with Epstein-Barr Virus Infection
Developmental Medicine & Child Neurology
Mary Connolly and Anne K. Junker and Ka Wah Chan and Kevin Farrell
DOI: 10.1111/j.1469-8749.1994.tb11797.x
11/2008

Quality of life and seizure outcome after vagus nerve stimulation in children with intractable epilepsy.
Journal of child neurology
Sherman EM and Connolly MB and Slick DJ and Eyrl KL and Steinbok P and Farrell K
DOI: 10.1177/0883073808315417
PubMed: 18474931
09/2008

Autosomal recessive GTP cyclohydrolase I deficiency without hyperphenylalaninemia: evidence of a phenotypic continuum between dominant and recessive forms.
Molecular genetics and metabolism
Horvath GA and Stockler-Ipsiroglu SG and Salvarinova-Zivkovic R and Lillquist YP and Connolly M and Hyland K and Blau N and Rupar T and Waters PJ
DOI: 10.1016/j.ymgme.2008.01.003
PubMed: 18276179
05/2008

Sociodemographic correlates of health-related quality of life in pediatric epilepsy
Epilepsy & Behavior
Elisabeth M.S. Sherman and Stephanie Y. Griffiths and Sare Akdag and Mary B. Connolly and Daniel J. Slick and Samuel Wiebe
DOI: 10.1016/j.yebeh.2007.07.009
01/2008

Epilepsy associated with a cerebellar arachnoid cyst: Seizure control following fenestration of the cyst
Child's Nervous System
Gan, Y.C. and Connolly, M.B.C. and Steinbok, P.
DOI: 10.1007/s00381-007-0439-x
2008

Surgical outcome in tuberous sclerosis complex: a multicenter survey.
Epilepsia
Madhavan D and Schaffer S and Yankovsky A and Arzimanoglou A and Renaldo F and Zaroff CM and LaJoie J and Weiner HL and Andermann E and Franz DN and Leonard J and Connolly M and Devinsky O
DOI: 10.1111/j.1528-1167.2007.01112.x
PubMed: 17484758
08/2007

ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy.
Epilepsia
Sherman EM and Slick DJ and Connolly MB and Eyrl KL
DOI: 10.1111/j.1528-1167.2007.01028.x
PubMed: 17381442
06/2007

The spectrum of SCN1A-related infantile epileptic encephalopathies.
Brain : a journal of neurology
Harkin LA and McMahon JM and Iona X and Dibbens L and Pelekanos JT and Zuberi SM and Sadleir LG and Andermann E and Gill D and Farrell K and Connolly M and Stanley T and Harbord M and Scheffer IE
DOI: 10.1093/brain/awm002
PubMed: 17347258
03/2007

Postsurgical health-related quality of life (HRQOL) in children following hemispherectomy for intractable epilepsy.
Epilepsia
Griffiths SY and Sherman EM and Slick DJ and Eyrl K and Connolly MB and Steinbok P
DOI: 10.1111/j.1528-1167.2006.00966.x
PubMed: 17284297
03/2007

Hemispheric surgery in children with refractory epilepsy: seizure outcome, complications, and adaptive function.
Epilepsia
Basheer SN and Connolly MB and Lautzenhiser A and Sherman EM and Hendson G and Steinbok P
DOI: 10.1111/j.1528-1167.2006.00909.x
PubMed: 17241220
01/2007

Pharmacological management of a youth with ADHD and a seizure disorder.
Journal of the American Academy of Child and Adolescent Psychiatry
Gonzalez-Heydrich J and Weiss M and Connolly M and Wambera K and Jan JE and Plioplys S and Dunn DW and Kratochvil CJ
DOI: 10.1097/01.chi.0000240836.71361.39
PubMed: 17135999
12/2006

Electroclinical features of absence seizures in childhood absence epilepsy.
Neurology
Sadleir LG and Farrell K and Smith S and Connolly MB and Scheffer IE
DOI: 10.1212/01.wnl.0000228257.60184.82
PubMed: 16894100
08/2006

Tuberous sclerosis complex: a review of the management of epilepsy with emphasis on surgical aspects
Child's Nervous System
Mary B. Connolly and Glenda Hendson and Paul Steinbok
DOI: 10.1007/s00381-006-0130-7
06/2006

6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia.
Annals of neurology
Demos MK and Waters PJ and Vallance HD and Lillquist Y and Makhseed N and Hyland K and Blau N and Connolly MB
DOI: 10.1002/ana.20532
PubMed: 15984017
07/2005

Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patienst with bipolar disorder: Consensus and controversies
Bipolar Disorders, Supplement
Yatham, L.N. and Kennedy, S.H. and O'Donovan, C. and Parikh, S. and MacQueen, G. and McIntyre, R. and Sharma, V. and Silverstone, P. and Alda, M. and Baruch, P. and Beaullieu, S. and Daigneault, A. and Milev, R. and Young, L.T. and Ravindran, A. and Schaffer, A. and Connolly, M. and Gorman, C.P.
2005

Preserved episodic memory in subcortical band heterotopia.
Epilepsia
Janzen L and Sherman E and Langfitt J and Berg M and Connolly M
DOI: 10.1111/j.0013-9580.2004.53203.x
PubMed: 15101838
05/2004

Neurophysiological investigations
Epilepsy in Children, 2E
Mary Connolly and Peter Wong
DOI: 10.1201/b13560-42
02/2004

Spasms in children with definite and probable mitochondrial disease.
European journal of neurology
Sadleir LG and Connolly MB and Applegarth D and Hendson G and Clarke L and Rakshi C and Farrell K
DOI: 10.1046/j.1351-5101.2003.00724.x
PubMed: 14748770
02/2004

Rasmussen syndrome
Epilepsy in Children, 2E
DOI: 10.1201/b13560-30
02/2004

Neurophysiological investigations
Epilepsy in Children, 2E
Connolly, M.B. and Wong, P.K.H.
2004

Epileptic syndromes with onset in middle childhood: Rasmussen syndrome
Epilepsy in Children, 2E
Connolly, M.B. and Arrell, K.F.
2004

Reexamining the effects of epilepsy surgery on IQ in children: use of regression-based change scores.
Journal of the International Neuropsychological Society : JINS
Sherman E and Slick DJ and Connolly MB and Steinbok P and Martin R and Strauss E and Chelune GJ and Farrell K
PubMed: 14632247
09/2003

Electrical fields and recording techniques
Current Practice of Clinical Electroencephalography, 3rd Edition
2003

Reexamining the effects of epilepsy surgery on IQ in children: Use of regression-based change scores
Journal of the International Neuropsychological Society
Sherman, E.M.S. and Slick, D.J. and Connolly, M.B. and Steinbok, P. and Martin, R. and Strauss, E. and Chelune, G.J. and Farrell, K.
DOI: 10.1017/S1355617703960085
2003

Risperidone in acute and continuation treatment of mania
International Clinical Psychopharmacology
Yatham, L.N. and Binder, C. and Riccardelli, R. and Leblanc, J. and Connolly, M. and Kusumakar, V.
DOI: 10.1097/00004850-200307000-00005
2003

Erratum: Melatonin does not trigger convulsions (Pediatrics and Child Health (2003)8:7(471))
Paediatrics and Child Health
Connolly, M.
2003

Melatonin does not trigger convulsions
Pediatrics and Child Health
2003

New antiepileptic drug therapies.
Neurologic clinics
Bergin AM and Connolly M
DOI: 10.1016/s0733-8619(02)00017-8
PubMed: 12616686
11/2002

Hyperventilation-induced high-amplitude rhythmic slowing with altered awareness: a video-EEG comparison with absence seizures.
Epilepsia
Lum LM and Connolly MB and Farrell K and Wong PK
DOI: 10.1046/j.1528-1157.2002.35101.x
PubMed: 12423387
11/2002

Validity of three measures of health-related quality of life in children with intractable epilepsy.
Epilepsia
Sherman EM and Slick DJ and Connolly MB and Steinbok P and Camfield C and Eyrl KL and Massey C and Farrell K
DOI: 10.1046/j.1528-1157.2002.03602.x
PubMed: 12366740
10/2002

Surgical Resection for Intractable Epilepsy in “Double Cortex” Syndrome Yields Inadequate Results
Epilepsia
A. Bernasconi and V. Martinez and P. Rosa-Neto and D. D'Agostino and N. Bernasconi and S. Berkovic and M. MacKay and A. Simon Harvey and A. Palmini and J. Costa Da Costa and Eliseu Paglioli and H.I. Kim and M. Connolly and A. Olivier and F. Dubeau and E. Andermann and R. Guerrini and W. Whisler and L. De Toledo-Morrell and F. Morrell and F. Andermann
DOI: 10.1046/j.1528-1157.2001.39900.x
01/2002

New antiepileptic drug therapies
Neurologic Clinics
Bergin, A.M. and Connolly, M.
DOI: 10.1016/S0733-8619(02)00017-8
2002

Temporal Lobectomy in Early Childhood: The Need for Long-Term Follow-Up
Journal of Child Neurology
Márcio A. Sotero de Menezes and Mary Connolly and Addison Bolanos and Joseph Madsen and Peter McL. Black and James J. Riviello
DOI: 10.1177/088307380101600809
08/2001

Postvaricella angiopathy: report of a case with pathologic correlation.
Pediatric neurology
Hayman M and Hendson G and Poskitt KJ and Connolly MB
DOI: 10.1016/s0887-8994(01)00272-7
PubMed: 11516617
05/2001

Postvaricella angiopathy: Report of a case with pathologic correlation
Pediatric Neurology
Hayman, M. and Hendson, G. and Poskitt, K.J. and Connolly, M.B.
DOI: 10.1016/S0887-8994(01)00272-7
2001

Cortical visual impairment in children with infantile spasms
Journal of AAPOS
Giovanni Castano and Christopher J. Lyons and James E. Jan and Mary Connolly
DOI: 10.1067/mpa.2000.104483
06/2000

Editorial Comment
Child's Nervous System
P. Steinbok and M. Connolly
DOI: 10.1007/s003810050515
05/2000

Factors associated with behavioral and cognitive abnormalities in children receiving topiramate.
Pediatric neurology
Gerber PE and Hamiwka L and Connolly MB and Farrell K
DOI: 10.1016/s0887-8994(99)00151-4
PubMed: 10734250
03/2000

Pediatric Peri-Insular Hemispherotomy
Pediatric Neurosurgery
J. Kestle and M. Connolly and D. Cochrane
DOI: 10.1159/000028896
2000

Factors associated with behavioral and cognitive abnormalities in children receiving Topiramate
Pediatric Neurology
Gerber, P.E. and Hamiwka, L. and Connolly, M.B. and Farrell, K.
DOI: 10.1016/S0887-8994(99)00151-4
2000

Cortical visual impairment in children with infantile spasms.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus
Castano, G. and Lyons, C.J. and Jan, J.E. and Connolly, M.
DOI: 10.1016/S1091-8531(00)70009-7
2000

Psychological assessment and treatment of psychogenic symptoms in children and adolescents
Non-epileptic Seizures, 2nd Edition
2000

Editorial Comment
Child's Nervous System
M. Connolly and P. Steinbok and G. Hendson
DOI: 10.1007/s003810050424
08/1999

Melatonin treatment of non-epileptic myoclonus in children.
Developmental medicine and child neurology
Jan JE and Connolly MB and Hamilton D and Freeman RD and Laudon M
DOI: 10.1017/s0012162299000535
PubMed: 10355809
04/1999

Non-invasive mapping of sensorimotor cortex in a child with a cavernous angioma: FMRI and high-resolution EEG compared with surgical mapping
NeuroImage
Bjornson, B. and Giaschi, D. and Cochrane, D. and Au Young, S. and Rootman, D. and Boden, C. and Connolly, M. and Poskitt, K. and Boyle, C. and Smith, S. and Akagemi, R. and Wong, P.K.H.
1999

Melatonin treatment of non-epileptic myoclonus in children
Developmental Medicine and Child Neurology
Jan, J.E. and Connolly, M.B.C. and Hamilton, D. and Freeman, R.D. and Laudon, M.
DOI: 10.1017/S0012162299000535
1999

High resolution EEG & seizure localization
NeuroImage
Wong, P.K.H. and Bjornson, B. and Connolly, M. and Steinbok, P. and Young, S.A. and Giaschi, D. and Gregory, D. and Smith, S. and Lee, R. and Man, A. and Cochrane, D.
1999

Acquired brachial-plexus neuropathy in the neonate: a rare presentation of late-onset group-B streptococcal osteomyelitis.
Developmental medicine and child neurology
Sadleir LG and Connolly MB
PubMed: 9698064
07/1998

Encephalopathy complicating Henoch-Schönlein purpura: reversible MRI changes.
Pediatric neurology
Woolfenden AR and Hukin J and Poskitt KJ and Connolly MB
DOI: 10.1016/s0887-8994(98)00027-7
PubMed: 9682892
07/1998

Acquired brachial-plexus neuropathy in the neonate: A rare presentation of late-onset group-B streptococcal osteomyelitis
Developmental Medicine and Child Neurology
Sadleir, L.G. and Connolly, M.B.
1998

Encephalopathy complicating henoch schonlein purpura: Reversible MRI changes
Pediatric Neurology
Woolfenden, A.R. and Hukin, J. and Poskitt, K.J. and Connolly, M.B.
DOI: 10.1016/S0887-8994(98)00027-7
1998

Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy
Pediatric Neurology
Kevin Farrell and Mary B Connolly and Robert Munn and Shumin Peng and Laurie M MacWilliam
DOI: 10.1016/s0887-8994(97)00010-6
04/1997

Reengineering a home health care agency to achieve cost effectiveness
Home Health Care Management and Practice
Connolly, M.L.
DOI: 10.1177/108482239701000106
1997

Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy
Pediatric Neurology
Farrell, K. and Connolly, M.B. and Munn, R. and Peng, S. and MacWilliam, L.M.
DOI: 10.1016/S0887-8994(97)00010-6
1997

Home health care and burn care: An educational and economical program
Journal of Burn Care and Rehabilitation
Dattolo, J. and Trout, S. and Connolly, M.L.
DOI: 10.1097/00004630-199603000-00017
1996

Seizures involving the supplementary sensorimotor area in children: a video-EEG analysis.
Epilepsia
Connolly MB and Langill L and Wong PK and Farrell K
DOI: 10.1111/j.1528-1157.1995.tb00962.x
PubMed: 7555953
10/1995

Alternating paroxysmal dystonia and hemiplegia in childhood as a symptom of basal ganglia disease.
Journal of Neurology, Neurosurgery & Psychiatry
Y M Hart and D Tampieri and E Andermann and F Andermann and M Connolly and K Farrell
DOI: 10.1136/jnnp.59.4.453
10/1995

Home care of the prostate cryosurgery patient.
Today"s OR nurse
Connolly, M.L. and Russell, M. and Reyna, C.
1995

Rapid cycling in severely multidisabled children: a form of bipolar affective disorder?
Pediatric neurology
Jan JE and Abroms IF and Freeman RD and Brown GM and Espezel H and Connolly MB
DOI: 10.1016/0887-8994(94)90064-7
PubMed: 8198670
02/1994

Biological bases of brain function and disease
Journal of Epilepsy
Mary Connolly
DOI: 10.1016/0896-6974(94)90039-6
01/1994

Outpatient video-EEG monitoring in children.
Epilepsia
Connolly MB and Wong PK and Karim Y and Smith S and Farrell K
DOI: 10.1111/j.1528-1157.1994.tb02465.x
PubMed: 8026391
1994

Epilepsy in infants and children
Conn's Current Therapy
1994

Intrapartum Asphyxia in Term and Postterm Infants
Obstetrical & Gynecological Survey
A HALLIGAN and M CONNOLLY and T CLARKE and R P GLEESON and M HOLOHAN and T MATTHEWS and M KING and M R N DARLING
DOI: 10.1097/00006254-199306000-00009
06/1993

MRI in pseudotumour cerebri
Pediatric Neurology Briefs
1993

Searching for Human Epilepsy Genes: A Progress Report
Brain Pathology
Leppert, M. and McMahon, W.M. and Quattlebaum, T.G. and Bjerre, I. and Zonana, J. and Shevell, M.I. and Andermann, E. and Rosales, T.O. and Ronen, G.M. and Connolly, M. and Anderson, V.E.
DOI: 10.1111/j.1750-3639.1993.tb00764.x
1993

Seizure characteristics in chromosome 20 benign familial neonatal convulsions
Neurology
Ronen, G.M. and Rosales, T.O. and Connolly, M. and Anderson, V.E. and Leppert, M.
1993

Magnetic resonance imaging in pseudotumor cerebri.
Developmental medicine and child neurology
Connolly MB and Farrell K and Hill A and Flodmark O
PubMed: 1451939
12/1992

Clinical features for prediction of survival in neonatal muscle disease.
Pediatric neurology
Connolly MB and Roland EH and Hill A
DOI: 10.1016/0887-8994(92)90367-8
PubMed: 1388418
1992

MAGNETIC RESONANCE IMAGING IN PSEUDOTUMOR CEREBRI
Developmental Medicine & Child Neurology
Connolly, M.B. and Farrell, K. and Hill, A. and Flodmark, O.
DOI: 10.1111/j.1469-8749.1992.tb11422.x
1992

Visual evoked potentials and intracranial pressure-reply
Archives of Neurology
Connolly, M.B. and Jan, J.E. and Cochrane, D.D.
DOI: 10.1001/archneur.1992.00530350021011
1992

Letter to the editor: Rapid recovery from cortical visual impairment following correction of prolonged shunt malfunction
Archives of Neurology
1992

Hepatic dysfunction in Alström disease.
American journal of medical genetics
Connolly MB and Jan JE and Couch RM and Wong LT and Dimmick JE and Rigg JM
DOI: 10.1002/ajmg.1320400408
PubMed: 1746604
09/1991

Rapid recovery from cortical visual impairment following correction of prolonged shunt malfunction in congenital hydrocephalus.
Archives of neurology
Connolly MB and Jan JE and Cochrane DD
DOI: 10.1001/archneur.1991.00530210082028
PubMed: 1953421
09/1991

Intravenous immunoglobulin and pyridoxine-dependent seizures.
Neurology
Connolly MB and Jan JE and Junker AK
DOI: 10.1212/wnl.41.9.1524
PubMed: 1891109
09/1991

An approach to the diagnosis and treatment of seizures in children
Canadian Journal of Pediatrics
1991

Intravenous immunoglobulin and pyridoxine–dependent seizures
Neurology
Connolly, M.B. and Jan, J.E. and Junker, A.K.
DOI: 10.1212/WNL.41.9.1524
1991

Head shaking by visually impaired children: a voluntary neurovisual adaptation which can be confused with spasmus nutans.
Developmental medicine and child neurology
Jan JE and Groenveld M and Connolly MB
PubMed: 2286305
12/1990

Head Shaking By Visually Impaired Children: A Voluntary Neurovisual Adaptation Which Can Be Confused With Spasmus Nutans
Developmental Medicine & Child Neurology
Jan, J.E. and Groenveld, M. and Connolly, M.B.
DOI: 10.1111/j.1469-8749.1990.tb08524.x
1990

Cost of neonatal intensive and special care
Irish Medical Journal
02/1989

Organize your workday: For more effective discharge planning
Nursing
Connolly, M.L.
DOI: 10.1097/00152193-198107000-00015
1981

Research

Acute psychiatric adverse events associated with Levetiracetam therapy in children with epilepsy
This study analyzes acute psychiatric adverse events (PAEs) in children receiving Levetiracetam, a new anti-epileptic drug. Predisposing factors such a personal or family history of psychiatric illness dosing schedules are reviewed. The aim is to identify risk factors and try to minimize PAEs on Levetiracetam.

Outcome Trajectories in Children with Epilepsy: What Factors are Important?
Our centre is participating in this multicentre study funded by CIHR. A variety of factors, both environmental and organic, influence the life quality outcomes in children with epilepsy. Our hypothesis that changes in children’s outcomes over time will be more strongly related to child and family psychosocial factors than to epilepsy-specific variables. The outcomes examined in this study include biomedical health and functional status (primarily mental health and intellectual abilities), academic achievement and participation. We will also measure the subjective experience of epilepsy with generic and condition-specific self- and proxy-reported ‘quality of life’ (HRQL) instruments.

Outcome following epilepsy surgery
Since the epilepsy surgery program was established, I have personally followed all children who have had surgery longitudinally from a clinical perspective. Neuropsychological and quality of life studies have been performed prior to surgery and on follow-up.

With colleagues in neurosurgery and neuropsychology, I have published several papers on long-term outcomes and quality of life following hemispheric surgery, surgery for tuberous sclerosis and vagus nerve stimulation. We also recently reported the a group of children with refractory status epilepticus who had urgent epilepsy surgery. A recent study of epilepsy surgery in the first 3 years of life across Canada, one of the largest series in young children in the literature, outlines the success in this group.

I am currently studying outcomes in children who had epilepsy surgery in the frontal lobe and assessing factors which may negatively affect the outcome. I am also studying the long-term outcome in children who had temporal lobe surgery and assessing outcomes and the influence of neuropsychiatric disorders such as depression, psychosis and anxiety on outcome.

Grants

2014-2022 Impact of Pediatric Epilepsy Surgery on Health-Related Quality of Life

2019 An Open-Label Extension Trial to Assess the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution as an Adjunctive Therapy for Seizures in Patients with Rare Seizure Disorders Such as Epileptic Encephalopathies Including Dravet Syndrome and Lennox- Gastaut Syndrome

2022-2023 An Open-Label n Study of XEN496 in Pediatric Subjects with KCNQ2 Developmental and Epileptic EncephalopathyExtensio

2022-2023 A Phase 3 Study of Adjunctive XEN496 in Pediatric Subjects with KCNQ2 Developmental and Epileptic Encephalopathy

2023-2026 A 20-Week Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of EPX-100 (Clemizole Hydrochloride) as Adjunctive Therapy in Patients with Dravet Syndrome

Canadian Epilepsy Database and Registry (CEDAR)

Honours & Awards

2002 Partners in Care Award – BC Children’s Hospital

2005 First Recipient of the Annual Dr. Parminder Singh Award of Distinction for most valuable subspecialty consultant – BC Pediatric Society

2015 Clinical Practice and Advocacy Award from the Canadian League Against Epilepsy

2021 Clinician Practitioner Excellence in Leadership Award from the Pediatrics Chairs of Canada

Award of Distinction from Partners in Care - BC Children’s Hospital, 2006

BC Children’s Hospital Education Award - Education Day for Families, 2005

Research Group Members

Elena Mihaela Anghelina, Clinical Research Coordinator
Stephanie Kwok, Research Coordinator
Sharon Park, Clinical Research Coordinator
Vesna Popovska, Director, Research, Pediatric Neurology & Neurosurgery, UBC Adult Neurosurgery
Dora Xiong, Clinical Research Coordinator