• Görges, Matthias

    Titles
    Investigator, BC Children's Hospital

    Co-Lead, Clinical & Community Data, Analytics & Informatics, Evidence to Innovation, BC Children`s Hospital
    Assistant Professor (Partner), Anesthesiology, Pharmacology & Therapeutics, University of British Columbia 

    Degrees / Designations
    MSc, PhD
    Primary Area of Research
    Evidence to Innovation
    Secondary Area(s) of Research
    Phone
    604-875-2000 ext. 5616
    Fax
    604-875-2668
    Lab Phone
    Mailing Address

    BC Children's Hospital Research Institute
    Clinical Support Building 
    Room V3-324 
    948 West 28th Avenue
    Vancouver, BC  V5Z 4H4

    Research Areas
    • Patient monitoring alarms
    • Integrated medical displays
    • Decision support tools 
    • Closed loop control of anesthesia /sedation 
    • Mobile health (mHealth) applications
    • Data-driven continuous quality improvement
    Summary
    As part of an inter-disciplinary team of engineers, computer scientists, and health care providers, I am involved in a wide range of projects focusing on the development and application of new technology, primarily in the pediatric anesthesia and intensive care setting. My main goal is to extract clinically-useful information from vital signs and other clinical data, and to transform these data into information for better, more timely, and more efficient decision-making by clinicians.
    Current Projects

    Vital signs changes in neonates during general anesthesia: an objective method to compare cases
    General anesthesia in neonates has the potential to impair long term cognitive outcomes. However, given that anesthesia for urgent neonatal surgery cannot be avoided regardless of age, it is vitally important to understand the other factors that may contribute to poor long term outcomes. Attention is now directed to preventable factors such as changes in vital signs, which may have deleterious effects on cerebral perfusion in the neonatal brain. The goal of this research is to identify and prioritize rules for detecting vital sign deviations, and to develop a case severity score allowing comparison of cases with respect to the conduct of anesthesia. This tool will then be used to support future quality improvement projects and to facilitate future investigations into the conduct of neonatal anesthesia applied in multi-centre prospective studies. 

    Using thermoregulation metrics during scoliosis correction surgery as an example for team and individualized feedback mechanisms
    Unless something is measured, practitioners don’t know how they are doing and where improvements are needed. Engaging high-performing individuals’ desire to do better is not always readily achieved by checklists, policies or guidelines. Continuous feedback of performance data can improve professional practice and outcomes. In this study, feedback of thermoregulation metrics is used as one strategy to continuously improve  perioperative temperature management in our scoliosis patients. Individualized feedback, without changes in policy, is able to reduce monitoring delays significantly, and sustainably. 

    Automated intravenous anesthesia delivery to improve outcomes
    As a highly experienced, interdisciplinary team of engineers and clinician-scientists, we have developed a system that automatically adjusts drug dosing. It does so by comparing feedback on anesthesia depth, using processed electrical activity from the patient's brain to a clinician-selected target. By administering the right amount of anesthesia drugs to patients, it minimizes side effects of these drugs, and allows clinicians to focus on optimizing patient safety through complex, high-level decision making. We are currently evaluating the performance of this system during general anesthesia for both adults and children. Future work includes expanding this work towards other users, such as nurses, and settings, such as intensive care unit sedation. 

    Selected Publications

    For the latest publications, please visit Dr. Görges’s ORCID profile.

    1. Liu D, Görges M, Jenkins SA. University of Queensland vital signs dataset: development of an accessible repository of anesthesia patient monitoring data for research. Anesth Analg. 2012 Mar 20;114(3):584–9.

    2. Görges M, Ansermino JM, Whyte SD. A retrospective audit to examine the effectiveness of preoperative warming on hypothermia in spine deformity surgery patients. Paediatr Anaesth. 2013 Jun 5;23(11):1054–61.

    3. Koch SH, Weir C, Westenskow D, Gondan M, Agutter J, Haar M, Liu D, Görges M, Staggers N. Evaluation of the effect of information integration in displays for ICU nurses on situation awareness and task completion time: A prospective randomized controlled study. Int J Med Inform. 2013 Aug 25;82(8):665–75.

    4. Görges M, Winton P, Koval V, Lim J, Stinson J, Choi PT, Schwarz SKW, Dumont GA, Ansermino JM. An evaluation of an expert system for detecting critical events during anesthesia in a human patient simulator: a prospective randomized controlled study. Anesth Analg. 2013 Aug 18;117(2):380–91.

    5. Brown ZE, Görges M, Cooke E, Malherbe S, Dumont GA, Ansermino JM. Changes in cardiac index and blood pressure on positioning children prone for scoliosis surgery. Anaesthesia. 2013 Jul 27;68(7):742–6.

    6. Dawes J, Myers D, Görges M, Zhou G, Ansermino JM, Montgomery CJ. Identifying a rapid bolus dose of dexmedetomidine (ED50) with acceptable hemodynamic outcomes in children. Paediatr Anaesth. 2014 Jul 14;24(12):1260–7.

    7. Dunsmuir DT, Payne BA, Cloete G, Petersen CL, Görges M, Lim J, von Dadelszen P, Dumont GA, Ansermino JM. Development of mHealth applications for pre-eclampsia triage. IEEE J Biomed Heal Informatics. 2014 Nov;18(6):1857–64.

    8. Görges M, West N, Deyell R, Winton P, Cheung W, Lauder G. Dexmedetomidine and hydromorphone: A novel pain management strategy for the oncology ward setting during anti-GD2 immunotherapy for high-risk neuroblastoma in children. Pediatr Blood Cancer. 2015 Jan 26;62(1):29–34.

    9. Görges M, Whyte SD, Sanatani S, Dawes J, Montgomery CJ, Ansermino JM. Changes in QTc associated with a rapid bolus dose of dexmedetomidine in patients receiving TIVA: a retrospective study. Pediatric Anesthesia. 2015 Dec;25(12):1287–93

    10. Görges M, West N, Christopher N, Koch J, Brodie S, Lowlaavar N, Lauder G, Ansermino JM. An Ethnographic Observational Study to Evaluate and Optimize the Use of Respiratory Acoustic Monitoring in Children Receiving Postoperative Opioid Infusions. Anesthesia & Analgesia. 2016 Apr; 122(4):1132-40. 
    Grants
    1. 2011-09, Postdoctoral Fellowship, Canadian Institutes of Health Research

    2. 2013-04, iACT Trainee Clinical Investigator Seed Grant, Child and Family Research Institute

    3. 2014-11, iACT Trainee Clinical Investigator Seed Grant, Child and Family Research Institute

    4. 2016-04, Residents' Research Grant [PI: Terri Sun], Canadian Anesthesiologists' Society 
    Honours & Awards
    1. 2007-01, Graduate Membership, Golden Key International Honour Society

    2. 2011-04 Best abstract of category Equipment/Monitoring, International Anesthesia Research Society

    3. 2011-05, 2nd place - Scientific and Educational Exhibits, International Anesthesia Research Society

    4. 2013-06, Trainee Research Award for Outstanding Achievement by a Post-Doctoral Fellow, Child & Family Research Institute,

    5. 2014-01, Excellence in Technology Award. [A Umedaly presented the work], Society for Technology in Anesthesia

    6. 2014-04, UBC Killam Postdoctoral Fellow Research Prize, Izaak Walton Killam Memorial Fund for Advanced Studies

    7. 2014-05, Free paper first prize winner. [J Dawes presented the work], Association of Paediatric Anaesthetists of Great Britain and Ireland 
    Research Group Members