• Bedaiwy, Mohamed Ali

    Titles

    Investigator, BC Children's Hospital
    Division Head and Professor, Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynaecology

    Degrees / Designations

    MD, PhD, FACOG

    Primary Area of Research
    Healthy Starts
    Secondary Area(s) of Research
    Phone
    604-875-2000 ext. 4310
    Fax
    604-875-2987
    Lab Phone
    Assistant
    Krystina Tran
    Assistant Phone
    604-875-2572
    Mailing Address

    BC Children's Hospital
    Room D415A
    4500 Oak Street
    Vancouver, BC  V6H 3N1

    Affiliate Websites
    Research Areas
    • Endometriosis
    • Reproductive biology
    • Minimally invasive surgery
    Summary

    My primary focus is in exploring molecular and genetic mechanisms explaining the cause of endometriosis. Endometriosis is a disease where the lining of the uterus is implanted in the abdomen. The exact cause of this disease is unknown. We are looking into specific changes in the genome of those patients that may explain the disease. As a result, specific targeted treatment could be developed for this devastating disease.

    The other focus of our research is to look into mechanisms to improve on the in vitro conditions of human embryo development. We are also looking to optimize the current techniques used for embryo freezing.

    In addition, we are looking into the safety aspects of doing minimally invasive surgery using robotics.

    Current Projects

    Progesterone receptor expression and different endometriosis phenotypes 

    Study question: Does endometriosis alter the expression profiles of progesterone receptor isoforms (PR-A and PR-B) consistently in eutopic endometrium, peritoneal and ovarian endometriosis?

    Summary answer: A PR A dominant state is detected uniformly in eutopic endometrium, peritoneal endometriosis and ovarian endometriomas in all phases of the menstrual cycle  compared to healthy controls. 

    Surgical anatomy for supraumbilical port placements: implications for laparoscopic surgery

    With advent of robotic surgery and laparoscopic surgery for large masses, supraumbilical port placements are required. Understanding the surgical anatomy of this region is mandatory for safe and succesful access. 

    The objective of this study is to establish the location of the aorta and the inferior vena cava (IVC) in relationship to and at one-centimetre increments above the umbilicus (one to five centimetres), and determine if it varies as a function of the abdominal wall thickness and patient BMI and to evaluate safety when operating laparoscopically in an obese population.

    Fibrinolytics System Gene Polymorphisms and Endometriosis Risk: A Prospective Nested Case-Control Investigation from the Nurses Health Study II

    Background: Several studies have identified associations between gene polymorphism in the inhibitors and stimulators of fibrinolysis in women with endometriosis. It remains unclear whether these polymorphisms are etiologically related to endometriosis.

    Objective: To examine single gene polymorphisms (SNPS) in the inhibitors of fibrinolysis, i.e., the plasminogen activator inhibitor type 1 (PAI-1), and tissue activatable fibrinolysis inhibitor (TAFI), and stimulators of fibrinolysis, i.e. tissue (tPA) and urokinase (uPA) plasminogen activator genes, in endometriosis patients and controls.

    Selected Publications
    1. Bedaiwy MA, Henry D, Liu J, Falcone T, Standardization of Laparoscopic Pelvic examination. Fertil  Steril. 2013 Apr;99(5):e11.
    2. Bedaiwy MA, Elnashar SA, Goldberg JM, Sharma R, Mascha EJ, Arrigain S, Agarwal A, Falcone T. Effect of follicular fluid oxidative stress parameters on intracytoplasmic sperm injection outcome. Gynecol Endocrinol. 2012 Jan;28(1):51-5.
    3. Bedaiwy MA, Abdelaleem MA, Hussein M, Mousa N, Brunengraber LN, Casper RF. Hormonal, follicular and endometrial dynamics in letrozole-treated versus natural cycles in patients undergoing controlled ovarian stimulation. Reprod Biol Endocrinol. 2011 Jun 21;9:83.
    4. Barakat EE, Bedaiwy MA, Zimberg S, Nutter B, Nosseir M, Falcone T. Robotic-assisted, laparoscopic, and abdominal myomectomy: a comparison of surgical outcomes. Obstet Gynecol. 2011 Feb;117(2 Pt 1):256-65.
    5. Bedaiwy MA, Falcone T. Whole ovary transplantation. Clin Obstet Gynecol. 2010 Dec;53(4):797-803.
    6. Bedaiwy MA, Mahfouz RZ, Goldberg JM, Sharma R, Falcone T, Abdel Hafez MF, Agarwal A. Relationship of reactive oxygen species levels in day 3 culture media  to the outcome of in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril. 2010 Nov;94(6):2037-42.
    7. Bedaiwy MA, Mousa NA, Casper RF. Aromatase inhibitors prevent the estrogen rise associated with the flare effect of gonadotropins in patients treated with GnRH agonists. Fertil Steril. 2009 Apr; 91(4 Suppl):1574-7.
    8. Bedaiwy MA, Hussein MR, Biscotti C, Falcone T. Pelvic Endometriosis is Rarely Associated with Ovarian Borderline Tumours, Cytologic and Architectural Atypia: A Clinicopathologic Study. Pathol Oncol Res. 2009 Mar; 15(1):81-8.
    9. Bedaiwy MA, Shahin AY, AbulHassan AM, Goldberg J, Sharma RK, Agarwal A, Falcone T. Differential expression of follicular fluid cytokines: relationship to subsequent pregnancy in IVF cycles. Reprod Biomed Online. 2007 Sep; 15(3):321-5.
    10. Bedaiwy MA, N Mousa, R Forman., Caspre RF, Follicular phase dynamics with combined aromatase inhibitor and follicle stimulating hormone treatment. J Clin Endocrinol Metab. 2007 Mar; 92(3):825-833.
    11. Bedaiwy MA, Hussein MR, Biscotti C, Falcone T Harvesting and autotransplantation of vascularized ovarian grafts: approaches and techniques.Reprod Biomed Online. 2007 Mar; 14(3):360-60.         Bedaiwy MA, Mousa N, Forman R, Al-Inany H, Casper RF, Cost-effectiveness of aromatase inhibitor co-treatment for controlled ovarian stimulation. Hum Reprod. 2006 Nov; 21(11):2838-44.
    12. Agarawal A, Said TM, Bedaiwy MA, Alvarez J., Oxidative stress in an assisted reproductive techniques setting. Fertil Steril. 2006 Sep; 86(3):503-12.
    13. Bedaiwy MA, Agarawal A, Said TM, Goldberg JM, Sharma RK, Worley S, Falcone T. Role of total antioxidant capacity in the differential growth of human embryos in vitro. Fertil Steril. 2006 Aug; 86(2):304-9.
    14. Bedaiwy MA, Caspre RF, Treatment with leuprolide acetate and hormonal add-back for up to 10 years in stage IV endometriosis patients with chronic pelvic pain. Fertil Steril. 2006 Jul; 86(1):220-2.
    15. Bedaiwy MA, Falcone T, Mascha E., Caspre RF,Genetic polymorphism in the fibrinolytic system and endometriosis. Obstet Gynecol. 2006 Jul; 108(1):162-8.
    16. Bedaiwy MA, Alfaraj S, Yong P, Casper R. New developments in the medical treatment of endometriosis. Fertil Steril. 2017 Jan 27. PMID: 28139238 
    17. Bedaiwy MA, Allaire C, Yong P, Alfaraj S. Medical Management of Endometriosis in Patients with Chronic Pelvic Pain.Semin Reprod Med. 2016 Dec 21. PMID: 28002850 
    18. Bedaiwy MA, Allaire C, Alfaraj S. Long-term medical management of endometriosis with dienogest and with a gonadotropin-releasing hormone agonist and add-back hormone therapy. Fertil Steril. 2017 Jan 27. PMID: 28139239 

    Grants
    Title: Prediction of Assisted Reproduction Outcome
    Source: The Egyptian Ministry of Higher Education  
    Position: PI
    Period: 1999-2002
    Direct Costs: $75,000.00

    Title: The Role of Cytokines and Oxidative Stress on Fertility in Laparoscopically Retrieved Peritoneal Fluid from Patients With Endometriosis
    Source: Cleveland Clinic Foundation, IRB# 2156  
    Position: Co-investigator (PI: Falcone)
    Period: 1999-2002
    Direct Costs: $98,268.00

    Title: Laparoscopic Ureteral Injury in a Porcine Model, a Pilot Study
    Source: Cleveland Clinic Foundation,  RPC # 6291.
    Position: Co-investigator (PI: Inderbir Gill)
    Period: 2000-2001
    Direct Costs: $6,203

    Title: Evaluation of Reproductive Outcomes and Pelvic Pain after Surgical Treatment of Different Stages of Endometriosis 
    Source: Cleveland Clinic Foundation, IRB# 2600
    Position: Co-investigator (PI: Falcone)
    Period: 2000-2001
    Direct Costs: $1,900

    Title: Effect of Hydrosalpinx Fluid on Early Embryo Development  
    Source: Organon, IRB#1505
    Position: Co-investigator (PI: Goldberg)
    Period: 2000-2001
    Direct Costs: $5,000

    Title: The Effect of Oxidative Stress on In Vitro Mouse Embryo Development 
    Source: Cleveland Clinic Foundation, RPC# 6485 
    Position: Co-investigator (PI: Falcone)
    Period: 2000-2001
    Direct Costs: $12,104

    Title: Reproductive Functions in Hydrocephalic Females Treated with Endoscopic Ventriculostomy
    Source: Cleveland Clinic Foundation, IRB# 4126
    Position: Principal investigator 
    Period: 2000-2003
    Direct Costs: 5,000

    Title: Laparoscopic Oophorectomy and Autotransplantation of Cryopreserved Ovarian Tissue and Entire Sheep Ovaries
    Source: Cleveland Clinic Foundation, RPC# 6624
    Position: Principal investigator 
    Period: 2000-2001
    Direct Costs: $6,203

    Title: Histology and Strength of Laparoscopic Uterine Incisions Made With Monopolar Laser
    Source: Cleveland Clinic Foundation, RPC # 6642
    Position: Co-investigator (PI: Muir)
    Period: 2001-2002
    Direct Costs: $18,581

    Title: Assisted Laparoscopic Autotransplantation of Ovine Hemi-Ovaries 
    Source: Cleveland Clinic Foundation, RPC#6558.  
    Position: Principal investigator 
    Period: 2001-2002
    Direct Costs: $6,203

    Title: Investigation of Female Mongrel as an Animal Model of Laparoscopically Induced Vesicovaginal Fistula
    Source: Cleveland Clinic Foundation 
    Position: Co-investigator (PI: Cogan)
    Period: 2001-2002
    Direct Costs: $12,822

    Title: Prevention of Vesicovaginal Fistulas in Laparoscopic Hysterectomy with Electrosurgical Induced Cystotomy
    Source: Cleveland Clinic Foundation, RPC#6664,  
    Position: Co-investigator (PI: Cogan)
    Period: 2001-2002
    Direct Costs: $23,381

    Title: Laparoscopic Uretrocystoplasty Using Balloon Expanded Normal Ureter: Chronic Porcine Study 
    Source: Cleveland Clinic Foundation, RPC# 6641  
    Position: Co-investigator (PI: Desai)
    Period: 2001-2002
    Direct Costs: $25,000

    Title: Autotransplatation of cryopreserved thawed ovarian tissue with microvascular anastomosis. 
    Source: Cleveland Clinic Foundation, RPC # 6624,  
    Position: Principal investigator
    Period: 2001-2003
    Direct Costs: $25,000.

    Title: Autotransplantation of cryopreserved-thawed mammalian ovary: assessment of long term function
    Source: Cleveland Clinic Foundation , RPC#  07031
    Position: Principal investigator 
    Period: 2001-2003
    Direct Costs: $25,000.

    Title: Assessment of Anti-Mullerian Hormone (AMH) Levels in Prepubertal Children Undergoing Gonadotoxic Chemotherapy
    Source: Cleveland Clinic Foundation
    Position: Principal investigator
    Period: 2006-2009
    Direct Costs: $35,000
    Honours & Awards
    1. ASRM Star Award, at the 69th Annual meeting of the American Society for Reproductive Medicine (ASRM) and the IFFS, Boston, MA, USA, October 12-17, 2013.
    2. Society for Reproductive Surgery Award, (Surgical Anatomy of the Supraumbilical Region: Implications for Laparoscopic and Robotic surgery). at the 69th Annual meeting of the American Society for Reproductive Medicine (ASRM) and the IFFS, Boston, MA, USA, October 12-17, 2013.
    3. First Prize in Technical Achievement in Video 2012. (Standardization of Laparoscopic Pelvic Examination)  at the 68th Annual meeting of the American Society for Reproductive Medicine, San Deigo, CA, USA, October 20-24, 2012.
    4. ASRM Star Award, at the 68th Annual meeting of the American Society for Reproductive Medicine, San Deigo, CA, USA, October 20-24, 2012.
    5. ASRM Star Award, at the 67th Annual meeting of the American Society for Reproductive Medicine, Orlando, Fl, USA, October 14-19, 2011.
    6. Yousef Award for Excellence in Obstetrics and Gynecology, Egyptian Academy of Science and Technology, Ministry of Higher Education, Egypt, June 2012.
    7. State Award for Excellence in Advanced Medical Sciences, Egyptian Academy of Science and Technology, Ministry of Higher Education, Egypt, June 2011.
    8. The Society of Reproductive Surgeons Award titled ‘Robotic assisted, laparoscopic and open myomectomy: a comparison of surgical outcome " at the 66th Annual meeting of the American Society for Reproductive Medicine, Denver, CO, USA October 23-28, 2010. 
    9. Shoman prize for the best medical research in the Middle East for the over all publications Shoman Foundation, Amann, Jordan, September 18, 2010.
    10. ACOG District V District V Fellows Surgical Film Festival Award titled “Single Incision Laparoscopy – right salpingjectomy for ectopic pregnancy“ Indiana University,  Indianapolis, USA September 15, 2010.
    11. AAGL Award for Special Excellence in laparoscopic Surgery:  The American Association for Gynecologic Laparoscopists. 2010
    12. Cryopreservation of intact human ovary with its vascular pedicle. (Bedaiwy et al. 2006, Hum Reprod 21:3258) was selected to be among the most important papers that changed the history of Assisted Reproduction in the world. This could be accessed at: http://www.ivf-worldwide.com/ivf-history.html
    13. First place in the Cleveland Society of Obstetrics and Gynecology titled ‘‘Prepubertal ovarian reserve screening: role of AMH’’ at the Annual Cleveland society of Gynecology meeting, 2010 at Cleveland, Ohio.
    14. AAGL Award for Special Excellence in laparoscopic Surgery:  The American Association for Gynecologic Laparoscopists. 2009
    15. Stump the Professors Award (District V) The American College of Obstetrics and Gynecology. 2009
    16. ASRM Resident Reporter 64 th  Annual Meeting of the American Society for Reproductive Medicine, San Francisco, California, USA.
    17. Honorary mention Reproductive Surgery category: Bedaiwy MA, Falcone T Robotically assisted myomectomy ASRM 2008, November 8−12, in San Francisco, California.
    18. First video award Reproductive Surgery category titled the use of epigastric vessels to vascularize fresh and cryopreserved-thawed ovarian transplants at: 59th Annual Meeting of the American Society for Reproductive Medicine (2003), October 11-15, 2003, Henry B. Gonzalez Convention Center, San Antonio, Texas USA.
    19. ESHRE travel award titled, ‘‘The use of the deep inferior epigastric vessels to vascularized fresh and cryopreserved thawed ovarian grafts’ at the 19th Annual meeting of the European Society for Human Reproduction and embryology (ESHRE), Madrid, Spain June 30-July 2nd, 2003.
    20. Poster award (general program) titled, ‘‘Histological evaluation and in situ localization of apoptosis in cryopreserved ovarian tissue’ at the 58th Annual meeting of the American Society for Reproductive Medicine, Seattle, WA, USA October 17-22, 2002. 
    21. American Society for Reproductive Medicine Educational Video Library Falcone T. Bedaiwy MA, Muir T, Robotically assisted gynecologic Surgery” August 29, 2002 for educational purposes.
    22. First video award Reproductive Surgery category titled, ‘‘robotically assisted gynecologic surgery’ at the 58th Annual meeting of the American Society for Reproductive Medicine, Seattle, WA, USA October 17-22, 2002.
    23. The Society of Reproductive Surgeons Award titled‘Autotransplantation of intact cryopreserved-thawed mammalian ovary with microvascular anastomosis" at the 58th Annual meeting of the American Society for Reproductive Medicine, Seattle, WA, USA October 14-17, 2002.
    24. The 3rd Royan International Research Award titled ‘Autotransplantation of intact cryopreserved-thawed mammalian ovary with microvascular anastomosis" at the The 3 rd Annual meeting of the Royan Institute, Tehran, Iran, September 11-13, 2002.
    25. Fellow Award titled ‘Autotransplantation of intact cryopreserved-thawed ovary with microvascular anastomosis: a novel approach" at the Annual meeting of the Cleveland Society of Obstetrics and Gynecology, Cleveland, Oh, USA, May15, 2002.
    26. Serono-In training Award titled ‘Autotransplantation of intact cryopreserved-thawed ovary: a minimally invasive approach” at the 50th Annual meeting of the Pacific Coast Reproductive Society PCSR, Palms Springs Ca, USA, April 17-21, 2002.
    27. First video award Reproductive Surgery category titled, ‘‘Ovarian autotransplantation with vascular anastomosis” at the 57th Annual meeting of the American Society for Reproductive Medicine, Orlando, FL, USA October 20-25, 2001.
    28. First video award Assisted Reproduction category, titled ‘‘ultrasound guided embryo transfer” at the 57th Annual meeting of the American Society for Reproductive Medicine, Orlando, FL, USA October 20-25, 2001.
    29. American Society for Reproductive Medicine Educational Video Library Bedaiwy MA, Miller K, Andrews B, Falcone T ‘‘ultrasound guided embryo transfer” August 13, 2001 for educational purposes.
    30. American Society for Reproductive Medicine Educational Video Library Jeremias E, Bedaiwy MA, Gurunluoglu R, Siemionow M, Falcone T. ‘‘Ovarian autotransplantation with vascular anastomosis” August 13, 2001, for educational purposes.
    31. Certificate of distinction, Fellow of the year 2001, from the Urological institute and department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA. 
    32. Trainee Merit Award by the National Institute of Health and international society of Andrology, titled ‘‘Novel semen quality scores can predict pregnancy in patients with male factor infertility undergoing intrauterine insemination’’ at the 7th International Congress of Andrology, Montreal, Canada, June 13-19, 2001.
    33. Second Prize in Cleveland Society of Obstetrics and Gynecology titled ‘‘Formation of Vesicovaginal Fistulas in Laparoscopic Hysterectomy with Electrosurgical Induced Cystotomy’’ at the Annual Cleveland society of Gynecology meeting, 2001 at Cleveland, Ohio.
    34. First prize in the 3rd annual transplant day of Cleveland Clinic Foundation, titled ‘‘the importance of ischemia time and tissue size in the preparation of ovarian tissue for cryopreservation’’ April, 20, 2001.
    Research Group Members