• Au, Nicholas

    Titles

    Investigator, BC Children's Hospital
    Medical Director, Transfusion Medicine Laboratory
    Clinical Assistant Professor, Department of Pathology and Laboratory Medicine, University of British Columbia

    Degrees / Designations
    MD. FRCPC
    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Phone
    604-875-2549
    Fax
    604-875-2815
    Lab Phone
    Assistant
    Dianne Langill
    Assistant Phone
    604-875-2306
    Mailing Address

    BC Children's Hospital
    Room 2K53
    4480 Oak St.
    Vancouver, BC V6H 3V4

    Affiliate Websites
    Research Areas
    • Hematopathology
    • Transfusion medicine
    Summary

    My research focuses on improvement of transfusion medicine practices, particularly as they apply to pediatric patients.

    Current Projects

    Neonatal alloimmune thrombocytopenia (NAIT) is a blood disease in newborns which develops when the pregnant mother produces antibodies that destroy the newborns' platelets. According to current guidelines, NAIT should be treated by transfusing a certain type of platelets (HPA-1a negative platelets). However, the availability of HPA-1a negative platelets is limited. I am currently conducting a study to determine if transfusion with random donor platelets is effective in treating NAIT.

    Red blood cells are frequently transfused in acute care institutions for the management of anemia, however research has shown that approximately 30% of red cell transfusions may be inappropriate. Red blood cells are derived from voluntary human donors and represent a precious medical resource.  Transfusions also carry risks to the recipient, some of which may lead to morbidity and even mortality.  I am participating in a quality study to assess the appropriateness of medical red cell transfusions.

    Selected Publications

    Yang MM, Singhal A, Au N, Hengel AR. Impact of preoperative laboratory investigation and blood cross-match on clinical management of pediatric neurosurgical patients.  Childs Nerv Syst. 2015 Apr;31(4):533-9. doi: 10.1007/s00381-015-2617-6. Epub 2015 Feb 19. PMID: 25694024

    Stockler S, Corvera S, Lambright D, Fogarty K, Nosova E, Leonard D, Steinfeld R, Ackerley C, Shyr C, Au N, Selby K, van Allen M, Vallance H, Wevers R, Watkins D, Rosenblatt D, Ross CJ, Conibear E, Wasserman W, van Karnebeek C.  Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking. Orphanet J Rare Dis. 2014 Sep 20;9(1):141. PMID: 25233840

    Sabr, Yasser; Gagne, Eric S; Delisle, Marie-France; Kent, Nancy; Nelson, Tanya N.; Brown, Lindsay A.; Schlade-Bartusiak, Kamilla; Rogers, Paul C.; Pritchard, Sheila; Wadsworth, Louis D.; Au, Nicholas. P-40: Prenatal presentation of fetal anemia associated with εγδβ-thalassemia: Two new cases.  (2014), Poster Abstracts of the ISPD 18th International Conference on Prenatal Diagnosis and Therapy. Prenat. Diagn., 34: 22–86.

    Wang L, Larkins N, Jung B, Au NH, Mammen C. Acute encephalopathy in a kidney transplant recipient following infusion of intravenous immunoglobulin. Transpl Int. 2014 Jun 25. doi: 10.1111/tri.12384. PMID: 24964219

    Lambert A, Wong AY, Kominami Y, Smith VC, Reddy S, Wadsworth LD, Au NH, MacGillivray RT. Microdeletion of exon 3 in the HBA2 gene associated with mild α-thalassemia trait. Hemoglobin. 2013;37(2):192-6. doi: 10.3109/03630269.2013.763257. PMID: 23356414

    Ting J, Hochwald O, Au N, Mercimek-Mahmutoglu S.  Blueberry muffin rash and thrombocytopenia in a newborn with mucolipidosis type II (I-cell disease) masquerading as congenital infections.  Mol Genet Metab.  2011 Dec;104(4):708-9. PMID: 21959079

    Grants
    Honours & Awards
    Research Group Members