• Yong, Paul

    Titles

    Investigator, BC Children's Hospital
    Gynaecologist, BC Women's Hospital & Health Centre
    Assistant Professor, Department of Obstetrics & Gynaecology, University of British Columbia

    Degrees / Designations
    MD, PhD, FRCSC
    Primary Area of Research
    Healthy Starts
    Secondary Area(s) of Research
    Phone
    604-875-2534
    Fax
    Lab Phone
    Assistant Phone
    604-875-2534
    Mailing Address
    Affiliate Websites
    Research Areas

    Pathophysiology of pain in endometriosis

    Summary

    Endometriosis affects one in ten women, and is a common cause of pelvic pain and infertility. It is a condition where tissue from inside the womb, grows outside the womb, typically elsewhere inside the abdomen.  In particular, endometriosis causes pelvic pain with intercourse (deep dyspareunia), which can have a devastating impact on women’s quality-of-life and relationships.

    The focus of my research is on how endometriosis causes deep dyspareunia.  I am investigating the genetic, cellular, nervous system, and psychological factors that lead to pain with intercourse in endometriosis.  The goal is to identify the ideal treatments to reduce pain and improve sexual function in endometriosis.

    Current Projects
    • Clinical predictors of deep dyspareunia in endometriosis:  Using a prospective database that I developed, I am investigating the variables from history, validated questionnaires, physical examination, and surgical findings, that are associated with deep dyspareunia (and other pain) in endometriosis.
    • Local neurogenesis and deep dyspareunia in endometriosis: I am studying the role of local nerve growth in the pelvis (the pouch of Douglas and uterosacral ligaments) as a cause of deep dyspareunia in endometriosis.
    • Pathophysiology of deep endometriosis: Deep invasive endometriosis is an invasive type of endometriosis that leads to deep dyspareunia and painful bowel movements (dyschezia).  I am exploring the cellular and genetic mechanisms behind this invasive form of endometriosis.
    Selected Publications
    Yong PJ, Sadownik LA, Brotto LA.  2015.  Concurrent deep-superficial dyspareunia in a multidisciplinary vulvodynia program.  Journal of Sexual Medicine 12(1):219-27

    Anglesio MS, Bashashati A, Wang YK, Senz J, Ha G, Yang W, Aniba R, Prentice LM, Farahani H, Chang HL, Karnezis AN, Marra MA, Yong PJ, Hirst M, Gilks CB, Shah SP, Huntsman DG.   2015.  Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden, including oncogenic alterations.  Journal of Pathology, epub ahead of print.

    Nourmoussavi M, Bodmer-Roy S, Mui J, Williams C, Allaire C, Yong PJ.  2014. Bladder base tenderness in the etiology of deep dyspareunia.  Journal of Sexual Medicine 11(12):3078-84.  

    Yong PJ, Mui J, Allaire C, Williams C.  2014.  Pelvic floor tenderness in the etiology of deep dyspareunia.  Journal of Obstetrics and Gynaecology Canada, (JOGC) 36(11):1002-9.

    Yong PJ, Mui J, Allaire C, Williams C, Britnell S.  2014.  Pelvic girdle pain in women with and without laparoscopically diagnosed endometriosis.  International Journal of Surgery Research and Practice, in press.

    Brotto LA, Yong PJ, Sadownik LA.  2015.  Impact of a multidisciplinary vulvodynia program on sexual functioning and dyspareunia.  Journal of Sexual Medicine 12(1):238-47.  (CA)

    Becker CM, Laufer MR, Stratton P, Hummelshoj L, Missmer SM, Zondervan KT, Adamson GD, for the WERF EPHect Working Group (includes Yong PJ).  2014.  WERF Endometriosis Phenome and Biobanking Harmonisation Project (EPHect): I. Surgical phenotype data collection in endometriosis research.  Fertility and Sterility 102(5):1213-22.

    Vitonis AF, Vincent K, Rahmioglu N, Fassbender A, Buck-Louis G, Hummelshoj L, Giudice LC, Stratton P, Adamson GD, Becker CM, Zondervan KT, Missmer SA, for the WERF EPHect Working Group (includes Yong PJ).  2014.  WERF Endometriosis Phenome and Biobanking Harmonisation Project (EPHect): II. Clinical and covariate phenotype data collection in endometriosis research.  Fertility and Sterility 102(5):1223-32.

    Rahmioglu N, Fassbender A , Vitonis AF, Tworoger S, Hummelshoj L, Adamson GD, Giudice LC,  Becker CM, Zondervan KT, Missmer SA, for the WERF EPHect Working Group (includes Yong PJ).  2014.  WERF Endometriosis Phenome and Biobanking Harmonisation Project (EPHect):  III. Fluid biospecimen collection, processing and storage in endometriosis research.  Fertility and Sterility 102(5):1233-43.

    Fassbender A, Rahmioglu N, Vitonis AF, Vigano P, Giudice LC, D'Hooghe TM, Hummelshoj L, Adamson GD, Becker CM, Missmer SA, Zondervan KT, for the WERF EPHect Working Group (includes Yong PJ).  2014.  WERF Endometriosis Phenome and Biobanking Harmonisation Project (EPHect):  IV. Tissue collection, processing and storage in endometriosis research.  Fertility and Sterility 102(5):1244-53. 
    Grants
    CIHR Operating Grant (2015-2018) ($282,000)
    CIHR Operating Grant Priority Announcement (2014-2015) ($100,000)
    CFI John Evans Leaders Fund (2015-2016) ($312,500 with matching funds)
    Canadian Foundation for Women’s Health (CFWH) General Research Grant (2013-2015) ($20,000)
    WHRI Nelly Auersperg Grant (2013) ($15,000)
    Honours & Awards
    Best oral presentation (Gynaecology), Society of Obstetricians and Gynaecologists of Canada (SOGC) Annual Meeting, Niagrara Falls, ON, June 2014.
    Best abstract in pelvic pain.  AAGL Global Congress, Vancouver, BC, October 2014.(Presented by trainee) 
    Resident Trainee Research Award, Child & Family Research Institute (CFRI), 2011.
    PhD Trainee Research Award, CFRI, 2004.
    Research Group Members