• Tilley, Peter

    Titles

    Investigator, BC Children's Hospital
    Medical Microbiologist & Head, Division of Microbiology, BC Children's Hospital and BC Women's Hospital & Health Centre
    Clinical Professor, Department of Pathology and Laboratory Medicine, University of British Columbia

    Degrees / Designations

    MD, FRCPC

    Primary Area of Research
    Healthy Starts
    Secondary Area(s) of Research
    Phone
    604-875-6694
    Fax
    Lab Phone
    Mailing Address

    BC Children's Hospital
    Room 2G11
    4480 Oak Street
    Vancouver, BC V6H 3V4

    Affiliate Websites
    Research Areas
    • Microbiology
    • Pediatric infectious disease
    • Diagnostics 
    • Sequencing
    Summary

    Timely and accurate diagnosis of infectious agents is of the utmost importance in treating pediatric patients. I am interested in exploring how new technologies can be applied to improve the diagnosis of infectious disease and enable the best possible care of children.

    Current Projects

    Early and accurate diagnosis of respiratory and central nervous system infections can lead to improved outcomes and earlier discharges, yet identification methods for such diseases are commonly available for only a limited number of infectious agents. Next generation sequencing (NGS) technology has shown promise for detection of a huge range of human pathogens from biological samples. I have been involved as a co-investigator in a pilot study examining a new lab process for NGS for the comprehensive detection of bacterial and viral pathogens in pediatric respiratory and cerebrospinal fluid samples.

    Selected Publications

    Hasan M, A Rawat, P Tang, P Jithesh, E Thomas, R Tan, and P Tilley. Depletion of human DNA in clinical specimens for detection of pathogens by shotgun metagenomic sequencing. Under review, Journal of Clinical Microbiology PMID: 26763966

    Hasan M, R Tan, G Al-Rawahi, E Thomas, P Tilley. Comparative evaluation of laboratory developed, real time PCR assays and RealStar® BKV PCR Kit for quantitative detection of BK polyomavirus. Submitted, Journal of Virological Methods. 

    Malcolmson C, K Ng, S Hughes, N Kissoon, J Schina, P Tilley, A Roberts. Impact of matrix-assisted laser desorption and ionization time of flight and antimicrobial stewardship intervention on treatment of bloodstream infections in hospitalized children. Under review, Pediatric Infectious Diseases Journal.

    Sorichetti B, Goshen O, Pauwels J, Kozak FK, Tilley P, Krajden M, Gantt S. Symptomatic Congenital Cytomegalovirus Infection Is Underdiagnosed in British Columbia. J Pediatr. 2015 Nov 17. 3476(15) 01308-6. PMID: 26597435

    Hasan MR, Tan R, Al-Rawahi G, Thomas E, Tilley P. Evaluation of amplification targets for the specific detection of Bordetella pertussis using real-time polymerase chain reaction. Can J Infect Dis Med Microbiol 25(4): 217-221, July 2014. PMID: 25285127

    Hasan MR, Brunstein JD, Al-Rawahi G, Tan R, Thomas E, Tilley P. PMID: 23053488. Current Microbiology 66(1) 61-3, Jan 2013.

    Hasan MR, Tan R, Al-Rawahi G, Thomas E, Tilley P. Short term stability of pathogen-specific nucleic acid targets in clinical samples. Journal of Clinical Microbiology 50(12) 4147-50, Oct 2012. PMID: 23052319

    Turvey SE, Leo SH, Boos A, Deans GD, Prendiville J, Crawford RI, Senger C, Conley ME, Tilley P, Junker A, Janz L, Azana R, Hoang L, Morton TL. Successful approach to treatment of Helicobacter bilis infection in X-linked agammaglobulinemia. Journal of Clinical Immunology 32(6) 1404-8, Dec 2012. PMID: 22843217
    Grants

    B.C. Children’s Hospital Telethon Grant Competition. $29,869 Sept 2012.

    Principal Investigator R Hasan. Application of Next Generation Sequencing to the diagnosis of respiratory illness in critically ill children.

    Honours & Awards
    Research Group Members