• Stewart, S. Evelyn

    Titles

    Investigator, BC Children's Hospital
    Director of Research for Child and Adolescent Psychiatry, BC Children's Hospital
    Associate Professor, Division of Clinical & Behavioural Neurosciences, Department of Psychiatry, University of British Columbia
    Medical Director, BCCH Provincial OCD Program (POP)
    Lecturer, Harvard Medical School
    Non-Clinical Consultant, Massachusetts General Hospital

    Degrees / Designations
    MD
    Primary Area of Research
    Brain, Behaviour & Development
    Secondary Area(s) of Research
    Phone
    604-875-2000 ext. 4725
    Fax
    Lab Phone
    Assistant
    Tracy Lau
    Assistant Phone
    604-875-2000 ext. 4741
    Mailing Address

    BC Children's Hospital Research Institute
    Room A3-121
    950 West 28th Avenue
    Vancouver, BC  V5Z 4H4

    Affiliate Websites
    Research Areas
    • Obsessive-Compulsive Disorder (OCD)
    • Translational research
    • Clinical Outcomes
    • Genetics
    • Cognition
    • Developmental trajectories
    • Imaging
    Summary

    Dr. Evelyn Stewart is an Associate Professor in the Department of Psychiatry, University of British Columbia and is the founding director of the Pediatric Obsessive-Compulsive Disorder Clinic and Research Program at BC Children and Women’s Health Centre. She is a clinical, genetic and neuroscience researcher, as well as a child and adult psychiatrist.

    Her research focuses on biologic, phenotypic, familial, and treatment aspects of childhood-onset neuropsychiatric disorders, such as obsessive-compulsive disorder (OCD). Dr. Stewart has authored over 70 original papers, reviews and chapters on genetic, clinical, and treatment aspects of OCD, Tourette's Disorder, and related illnesses. She previously sat on the Scientific and Clinical Advisory Board of the International OCD Foundation, on the Medical Advisory Board of the Tourette Syndrome Association of America and is Co-director of the International OCD Foundation Genetics Collaborative. 

    At BCCHR, she leads the BB&D theme and co-leads the MH group.

    Current Projects

    Neural Correlates in Childhood-onset OCD: The goal of this study is to evaluate for neurocognitive and neurosoft sign state and at-risk trait markers for OCD, by examining affected, at-risk and healthy youth.

    Brain Function and Structure in Pediatric Obsessive Compulsive Disorder: The goal of this study is to examine the cortical structure and functional activation in the regions implicated in OCD in OCD-affected, OCD-unaffected siblings, and healthy children and adolescents. A planning task conducted pre- and post-symptom provocation will be used to examine the impact of symptoms on executive function. In addition, DTI will record white matter structure and organization.

    As PI:

    • Obsessive-Compulsive Disorder (OCD) Registry and DNA Repository
    • Clinical Outcomes following Group-based Family Cognitive-Behaviour Therapy in Pediatric Obsessive- Compulsive Disorder (OCD).
    • Mindfulness Training versus Peer Support Groups for Parents of Obsessive-Compulsive Disorder
    • Objective measures of sleep and daily physical activity in pediatric Obsessive-Compulsive Disorder

    As Co-Investigator:

    • Cognitive and biological underpinnings of delusions in psychosis
    • Trends in Psychiatric Seasonal Emergency Admission
    Selected Publications

    Yao Y, Qin H, Samuels J, Wang Y, Zhu Y, Grados M, Riddle M, Greenberg B, Knowles J, Fyer A, McCracken J, Murphy D, Rasmussen S, Cullen B, Piacentini J, Geller D, Stewart SE, Pauls D, Bienvenu OJ, Goes F, Maher B, Pulver A, Valle D, Lange C, Mattheisen M, McLaughlin N, Liang K-Y, Nurmi E, Askland K, Nestadt G. Whole genome association analysis of serotonin reuptake inhibitor response in obsessive-compulsive disorder. Mol Psych. (in publication).

    Samuels J, Grados MA, Riddle MA, Bienvenu OJ, Goes FS, Cullen B, Wang Y, Greenberg BD, Fyer AJ, McCracken JT, Gellar D, Murphy DL, Knowles JA, Rasmussen SA, McLaughlin NC, Piacentini J, Pauls DL, Stewart SE, Shugart YY, Maher B, Pulver AE, Nestadt G. Hoarding in Children and Adolescents with Obsessive-Compulsive Disorder. J Obsess-Comp Rel Disorders, 2014 Oct 1, 3(4):325-331. PMID: 25309849.

    Rosso IM, Olson EA, Britton JC, Stewart SE, Papadimitriou G, Killgore WD, Makris N, Wilhelm S, Jenike MA, Rauch SL. Brain white matter integrity and association with age at onset in pediatric obsessive-compulsive disorder. Biology of Mood & Anxiety Disorders, 2014 Dec 18; 4(1):13. PMID: 25540681.

    Whiteley LE, Borgelt EL, Stewart SE, Illes J. Parent perspectives on biomarkers for OCD: Talking of difficult presents, desired pasts, and imagined futures. Biosocieties, (2015). 

    Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH, Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SM, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL, King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, Morgan J, Muller H, Murphy DL, Naarden AL, Nurmi E, Ochoa WC, Ophoff RA, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosário MC, Rosenberg D, Ruhrmann S, Sabatti C, Salvi E, Sampaio AS, Samuels J, Sandor P, Service SK, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Turiel M, Valencia Duarte AV, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Weale M, Weiss R, Wendland JR, Westenberg HG, Shugart YY, Hounie AG, Miguel EC, Nicolini H, Wagner M, Ruiz-Linares A, Cath DC, McMahon W, Posthuma D, Oostra BA, Nestadt G, Rouleau GA, Purcell S, Jenike MA, Heutink P, Hanna GL, Conti DV, Arnold PD, Freimer NB, Stewart SE, Knowles JA, Cox NJ, Pauls DL. Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD. Am J Psychiatry, 2014 Aug 26. PMID: 25158072. (Journal ranking in psychiatry = 2, IF=14.72)

    Association of the SLC1A1 glutamate transporter gene and obsessive‐compulsive disorder. SE Stewart, JA Fagerness, J Platko, JW Smoller, JM Scharf, C Illmann, ...American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144 ...

    Impact of comorbidity on treatment response to paroxetine in pediatric obsessive-compulsive disorder: is the use of exclusion criteria empirically supported in randomized clinical trials? DA Geller, J Biederman, SE Stewart, B Mullin, C Farrell, KD Wagner,...Journal of Child and Adolescent Psychopharmacology 13 (2, Supplement 1), 19-29

    Genome-wide association study of obsessive-compulsive disorder.SE Stewart, D Yu, JM Scharf, BM Neale, JA Fagerness, CA Mathews,...Molecular psychiatry 18 (7), 788-798

    A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. SE Stewart, J Platko, J Fagerness, J Birns, E Jenike, JW Smoller, R Perlis,...Archives of general psychiatry 64 (2), 209-214

    Genome scan for Tourette disorder in affected-sibling-pair and multigenerational families. Tourette Syndrome Association International Consortium for Genetics. The American Journal of Human Genetics 80 (2), 265-272

    Genome-wide association study of Tourette's syndrome. JM Scharf, D Yu, CA Mathews, BM Neale, SE Stewart, JA Fagerness, ...Molecular psychiatry 18 (6), 721-728

    Lack of association between SLITRK1var321 and Tourette syndrome in a large family-based sample. JM Scharf, P Moorjani, J Fagerness, JV Platko, C Illmann, B Galloway, ...Neurology 70 (16 Part 2), 1495-1496

    Suicidal children and adolescents with first emergency room presentations: predictors of six-month outcome. SE Stewart, IG Manion, S Davidson, P Cloutier. Journal of the American Academy of Child & Adolescent Psychiatry 40 (5), 580-587 

    Family‐based genetic association study of DLGAP3 in Tourette Syndrome. J Crane, J Fagerness, L Osiecki, B Gunnell, SE Stewart, DL Pauls,...American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156...

    Meta‐analysis of association between obsessive‐compulsive disorder and the 3′region of neuronal glutamate transporter gene SLC1A1. SE Stewart, C Mayerfeld, PD Arnold, JR Crane, C O'Dushlaine, ...American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162 ...

    Emergency management of the adolescent suicide attempter: a review of the literature.SE Stewart, IG Manion, S Davidson Journal of Adolescent Health 30 (5), 312-325

    Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features. SR Crowe, JT Merrill, ES Vista, AB Dedeke, DM Thompson, S Stewart, ...Arthritis & Rheumatism 63 (8), 2396-2406

    Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette’s syndrome and OCD. D Yu, CA Mathews, JM Scharf, BM Neale, LK Davis, ER Gamazon, ...American Journal of Psychiatry

    Group music therapy for severe mental illness: a randomized embedded-experimental mixed methods study. D Grocke, S Bloch, D Castle, G Thompson, R Newton, S Stewart, C Gold. Acta Psychiatrica Scandinavica 130 (2), 144-153

    Whole-genome association analysis of treatment response in obsessive-compulsive disorder. H Qin, JF Samuels, Y Wang, Y Zhu, MA Grados, MA Riddle, ....Molecular psychiatry

    Assessment and medication management of paediatric obsessive-compulsive disorder. SE Stewart, D Hezel, AC Stachon .Drugs 72 (7), 881-893

    The genetics of obsessive-compulsive disorder. SE Stewart, DL Pauls. Focus 8 (3), 350-357

    McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G, Wolf A, Schroeder FA, Osiecki L, O'Dushlaine C, Kirby A, Illmann C, Haddad S, Gallagher P, Fagerness JA, Barr CL, Bellodi L, Benarroch F, Bienvenu OJ, Black DW, Bloch MH, Bruun RD, Budman CL, Camarena B, Cath DC, Cavallini MC, Chouinard S, Coric V, Cullen B, Delorme R, Denys D, Derks EM, Dion Y, Rosário MC, Eapen V, Evans P, Falkai P, Fernandez TV, Garrido H, Geller D, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Heiman GA, Hemmings SM, Herrera LD, Hounie AG, Jankovic J, Kennedy JL, King RA, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Lochner C, Lowe TL, Lyon GJ, Macciardi F, Maier W, McCracken JT, McMahon W, Murphy DL, Naarden AL, Neale BM, Nurmi E, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Reus VI, Richter MA, Riddle M, Robertson MM, Rosenberg D, Rouleau GA, Ruhrmann S, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Tischfield JA, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Wendland JR, Shugart YY, Miguel EC, Nicolini H, Oostra BA, Moessner R, Wagner M, Ruiz-Linares A, Heutink P, Nestadt G, Freimer N, Petryshen T, Posthuma D, Jenike MA, Cox NJ, Hanna GL, Brentani H, Scherer SW, Arnold PD*, Stewart SE*, Mathews CA*, Knowles JA*, Cook EH*, Pauls DL*, Wang K, Scharf JM*. A cross-disorder, genome-wide analysis of copy number variation in Tourette Syndrome and Obsessive-Compulsive Disorder. Molecular Psychiatry. (April 2013) (in press). Copy number variation in obsessive-compulsive disorder and Tourette syndrome: a cross-disorder study. J Am Acad Child Adolesc Psychiatry, 2014 Aug; 53(8): 910-9. PMID: 25062598. (Co-SA) (Journal ranking in child psychiatry = 1, IF=6.97)

    Samuels J, Shugart YY, Wang Y, Grados MA, Bienvenu OJ, Pinto A, Rauch SL, Greenberg BD, Knowles JA, Fyer AJ, Piacentini J, Pauls DL, Cullen B, Rasmussen SA, Stewart SE, Geller DA, Maher BS, Goes FS, Murphy DL, MCCracken JT, Riddle MA, Nestadt G. Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive-compulsive disorder: Results from the OCD Collaborative Genetics Study. Am J Med Genet. B. 2014 Jun; 165B(4):326-36. PMID: 24798771.

    Mattheisen M, Samuels JF, Wang Y, Greenberg BD, Fyer AJ, McCracken JT, Geller DA, Murphy DL, Knowles JA, Grados MA, Riddle MA, Rasmussen SA, McLaughlin NC, Nurmi EL, Askland KD, Qin HD, Cullen BA, Piacentini J, Pauls DL, Bienvenu OJ, Stewart SE, Liang KY, Goes FS, Maher B, Pulver AE, Shugart YY, Valle D, Lange C, Nestadt G. Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. Mol Psychiatry. 2014 May 13. [Epub ahead of print] PMID: 24821223.

    Hoarding behavior among young children with obsessive–compulsive disorder. H Frank, E Stewart, M Walther, K Benito, J Freeman, C Conelea, A Garcia. Journal of obsessive-compulsive and related disorders 3 (1), 6-11

    COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based association study. AS Sampaio, AG Hounie, K Petribú, C Cappi, I Morais, H Vallada, ...PloS one 10 (3), e0119592

    Neurobiology of obsessive-compulsive disorder.TK MURPHY, KKS VOELLER, SE STEWART. Pediatric Psychopharmacology, 148

    Obsessive compulsive disorder. TK Murphy, SE Stewart, D Obregon. The Medical Basis of Psychiatry, 169-193

    Biological treatment for obsessive-compulsive disorder. SE Stewart, E Jenike, MA Jenike. Oxford handbook of anxiety and related disorders, 375-390

    Genetics of childhood-onset psychiatric disorders. SE Stewart, DL Pauls. Psychiatric Genetics. Washington DC. American Psychiatric Publishing, Inc

    Elevated Autism Spectrum Disorder Traits in Young Children with OCD. SE Stewart, MK Cancilliere, J Freeman, B Wellen, A Garcia, J Sapyta, ...Child Psychiatry & Human Development, 1-9

    MAO-A and COMT polymorphisms and OCD: A Brazilian family-based association study. AS Sampaio, SE Stewart, J Fargeness, C Mathews, P Arnold, G Hannah, ... Biological Psychiatry 67 (9), 114S-5S

    ADHD and executive functioning deficits in OCD youths who hoard. JM Park, JF Samuels, MA Grados, MA Riddle, OJ Bienvenu, FS Goes, ...Journal of psychiatric research 82, 141-148

    Inglis A, Koehn D, McGillivray B, Stewart SE, Austin J. Evaluating a unique, specialist psychiatric genetic counseling clinic: uptake and impact. Clin Genet. 2014 Apr 28; 87 (3), 218-224.[Epub ahead of print] PMID: 24773225.

    Sampaio AS, McCarthy KD, Mancuso E, Stewart SE, Geller DA. Validation of the University of São Paulo's Sensory Phenomena Scale - English version. Comprehensive Psychiatry. February 2014. Compr Psychiatry. 2014 Feb 25, 55(5): 1330-1336. PMID: 24666717.

    21.4 NEUROCOGNITION IN PEDIATRIC OBSESSIVE-COMPULSIVE DISORDER: CLINICAL IMPACTS AND FUTURE CONSIDERATIONS. SE Stewart, J Negreiros, L Belschner, S Lin Journal of the American Academy of Child & Adolescent Psychiatry 55 (10), S291

    51.5 GROUP AND FAMILY COGNITIVE BEHAVIORAL THERAPY FOR PEDIATRIC OBSESSIVE-COMPULSIVE DISORDER: EXAMINING TRADITIONAL AND NOVEL OUTCOMES. SE Stewart, KS McKenney, A Simpson, L Belschner, S Lin. Journal of the American Academy of Child & Adolescent Psychiatry 55 (10), S341

    6.115 SYMPTOM REDUCTION AND LENGTH OF STAY IN AN INTENSIVE PROGRAM FOR PEDIATRIC OBSESSIVE-COMPULSIVE DISORDER. SE Stewart, B Case, AM Garcia, JB Freeman. Journal of the American Academy of Child & Adolescent Psychiatry 55 (10), S241

    Pediatric Obsessive-Compulsive Disorder Exacerbation and Obstructive Hydrocephalus: A Case Report. A Leung, C Bleakley, A Loh, K Saran, SE Stewart. Pediatrics, e20160558

    Examining the Psychometric Properties of the Pediatric Quality of Life Enjoyment and Satisfaction Questionnaire in Two Samples of Youth with OCD. B Wellen, LC Skriner, J Freeman, E Stewart, A Garcia, J Sapyta, ...Child Psychiatry & Human Development, 1-9

    Obsessive-Compulsive Disorder. SE Stewart. Psychiatric Neurotherapeutics,2016, 23-50

    Obsessive-Compulsive Disorder: The Process of Parental Adaptation and Implications for Genetic Counseling. H Andrighetti, A Semaka, SE Stewart, C Shuman, R Hayeems, J Austin. Journal of genetic counseling, 1-11

    Multi-Site Study of Family Functioning Impairment in Pediatric Obsessive Compulsive Disorder. SE Stewart. 62nd Annual Meeting

    Tics, Other Comorbidities, and Their Implications in Pediatric Obsessive Compulsive Disorder.SE Stewart. 62nd Annual Meeting

    Tic-Related Obsessive Compulsive Disorder: Clinical Implications of the New DSM5 Specifier. SE Stewart. 62nd Annual Meeting.

    Social and Behavioural Research in Clinical Genetics. A Inglis, D Koehn, B McGillivray, SE Stewart, J Austin. CLINICAL GENETICS 87 (3), 218-224. 2015

    Booth B, Hatters-Friedman S, Curry S, Ward H, Stewart SE. Obsessions of child murder: under-recognized manifestations of obsessive-compulsive disorder. J Am Acad Psychiatry Law, September 2012. J Am Acad Psychiatry Law, 2014;42(1):66-74. PMID: 24618521. (SA)

    Hu Y-P, Wehrly R, Gorrindo T, Hezel D, Gironda C, Jenike M, Stewart SE. Gender Specific Short Stature in Male Adolescents with Obsessive-Compulsive Disorder. J Obsess-Comp Rel Disorders, January 2013, 2(1):30-36. (SA)

    Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Cardona Silgado JC, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen BA, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez TV, Gallagher PJ, Garrido H, Geller D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Haddad S, Heiman GA, Hemmings SM, Hounie AG, Illmann C, Jankovic J, Jenike MA, Kennedy JL, King RA, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Macciardi F, McCracken JT, McGrath LM, Mesa Restrepo SC, Moessner R, Morgan J, Muller H, Murphy DL, Naarden AL, Ochoa WC, Ophoff RA, Osiecki L, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner TJ, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosàrio MC, Rosenberg D, Rouleau GA, Ruhrmann S, Ruiz-Linares A, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Valencia Duarte AV, Vallada H, Van Nieuwerburgh F, Veenstra-Vanderweele J, Walitza S, Wang Y, Wendland JR, Westenberg HG, Shugart YY, Miguel EC, McMahon W, Wagner M, Nicolini H, Posthuma D, Hanna GL, Heutink P, Denys D, Arnold PD, Oostra BA, Nestadt G, Freimer NB, Pauls DL, Wray NR, Stewart SE, Mathews CA, Knowles JA, Cox NJ, Scharf JM. Partitioning the heritability of tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet. 2013 Oct;9(10). Epub 2013 Oct 24. PMID: 24204291. (IF 8.52)

    Muir KE, McKenney KS, Connolly MB, and Stewart SE. A case report of obsessive-compulsive disorder following acute disseminated encephalomyelitis. Pediatrics, 2013 Sep;132(3):e771-4. (SA) (Journal ranking in pediatrics = 1, IF 4.79). PMID: 23918895.

    SE Stewart, Mayerfeld C, Arnold PD, Crane JR, O'Dushlaine C, Fagerness JA, Yu D, Scharf JM, Chan E, Kassam F, Moya PR, Wendland JR, Delorme R, Richter MA, Kennedy JL, Veenstra-VanderWeele J, Samuels J, Greenberg BD, McCracken JT, Knowles JA, Fyer AJ, Rauch SL, Riddle MA, Grados MA, Bienvenu OJ, Cullen B, Wang Y, Shugart YY, Piacentini J, Rasmussen S, Nestadt G, Murphy DL, Jenike MA, Cook EH, Pauls DL, Hanna GL, Mathews CA. Meta-Analysis of Association between Obsessive-Compulsive Disorder and the 3’ Region of Neuronal Glutamate Transporter SLC1A1. Am J Med Genet B. 2013 Jun;162B(4):367-79. (FA). PMID: 23606572.

    Meta-Analysis of Association Between the Neuronal Glutamate Transporter Gene SLC1A1 and Obsessive Compulsive Disorder. SE Stewart. AACAP+ CACAP Joint Annual Meeting (October 18-23,2011)

    Scharf JM**, Yu D**, Mathews CA**, Neale BM**, Stewart SE**, Fagerness JA**, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A; for the North American Brain Expression Consortium, Hardy J; for the UK Human Brain Expression Database, Strengman E, Ophoff RA, Wagner M, Moessner R, Mirel DB, Posthuma D, Sabatti C, Eskin E, Conti DV, Knowles JA, Ruiz-Linares A, Rouleau GA, Purcell S, Heutink P, Oostra BA, McMahon WM, Freimer NB, Cox NJ, Pauls DL. Genome-wide Association Study of Tourette’s syndrome. Mol Psychiatry. 2013 Jun;18(6):721-8. (Co-FA) (Journal ranking in psychiatry = 1, IF 14.90). PMID: 22889924.

    Genome-Wide Association Study of Gilles de la Tourette Syndrome (IN 10-1.002). J Scharf, D Yu, C Mathews, B Neale, E Stewart, J Fagerness, P Evans, ...Neurology 78 (1 Supplement), IN10-1.002-IN 10-1.002. 2012

    Genome-Wide Association Study of Gilles de la Tourette Syndrome (S32. 006). J Scharf, D Yu, C Mathews, B Neale, E Stewart, J Fagerness, P Evans, ...Neurology 78 (1 Supplement), S32. 006-S32. 2012

    Stewart, SE. Rage Takes Center Stage: Focus on an Under-appreciated Aspect of Pediatric Obsessive Compulsive Disorder. J Am Acad Child Adolesc Psychiatry, 2012 Jun; 51(6):569-571. (SA) (Journal ranking in child psychiatry = 1, IF 6.97). PMID: 22632616.

    O'Rourke JA, Scharf JM, Platko J, Stewart SE, Illmann C, Geller DA, King RA, Leckman JF, Pauls DL. The Familial Association of Tourette’s Disorder and ADHD: The Impact of OCD Symptoms. Am J Med Genet. B. 2011 Jul;156(5):553-60. PMID: 21557467.

    Stewart SE, Hu YP, Hezel DM, Proujansky R, Lamstein A, Walsh C, Ben-Joseph EP, Gironda C, Jenike M, Geller DA, Pauls DL. Development and Psychometric Properties of the OCD Family Functioning (OFF) Scale. J Fam Psychol. 2011 Jun;25(3):434-43. (FA). PMID: 21553962.

    Delucchi KL, Katerberg H, Stewart SE, Denys DA, Lochner C, Stack DE, den Boer JA, van Balkom AJ, Jenike MA, Stein DJ, Cath DC, Mathews CA. Latent class analysis of the Yale-Brown Obsessive-Compulsive Scale symptoms in obsessive-compulsive disorder. Compr Psychiatry, 2011;52(3):334-41. PMID: 21145539.

    Shapiro LJ, Stewart SE. Pathological Guilt: A Persistent Yet Overlooked Treatment Factor in Obsessive-Compulsive Disorder. Ann Clin Psychiatry, 2011;23(1):63-70. (SA). PMID: 21318197.

    Sampaio AS, Fagerness J, Crane J, Leboyer M, Delorme R, Pauls DL, Stewart SE. Association between Polymorphisms in GRIK2 gene and Obsessive-Compulsive Disorder: a Family-based Study. CNS Neurosci Ther, 2011 Jun;17(3):141-147. (SA). PMID: 20370803.

    Parent perspectives on biomarkers for OCD: Talking of difficult presents, desired pasts, and imagined futures. LE Whiteley, EL Borgelt, SE Stewart, J Illes. Biosocieties. 2015

    Parent and Child Perspectives of Family-Functioning in Pediatric Obsessive Compulsive Disorder.SE Stewart. 61st Annual Meeting. 2014

    Journal of Obsessive-Compulsive and Related Disorders. J Samuels, MA Grados, MA Riddle, OJ Bienvenu, FS Goes, B Cullen,...

    Pharmacotherapy for obsessive-compulsive and related disorders among children and adolescents. SE Stewart, AC Stachon. American Psychological Association

    Association between MAO-A and Obsessive-Compulsive Disorder related phenotypes. AS Sampaio, AG Hounie, K Petribu, C Cappi, IA Morais, LC Quarantini, ...Journal of Obsessive-Compulsive and Related Disorders 2013 (2), 228-228

    Pharmacologic Management of Treatment-Resistant Pediatric Obsessive Compulsive Disorder. SE Stewart. 59th Annual Meeting

    Journal of Obsessive-Compulsive and Related Disorders. MS Wu, AB Lewin, TK Murphy, GR Geffken. EA Storch

    Genome-Wide Association Study of Gilles de la Tourette Syndrome (IN 10-1.002). J Scharf, D Yu, C Mathews, B Neale, E Stewart, J Fagerness, P Evans, ...Neurology 78 (1 Supplement), IN10-1.002-IN10-1.002

    Clinical Correlates and Specific Symptom Predictors of Family Functioning Impairment in Obsessive Compulsive Disorder. SE Stewart. AACAP+ CACAP Joint Annual Meeting (October 18-23,2011)

    Glutamate Modulating Agents in Treatment-Refractory Obsessive-Compulsive Disorder. SE Stewart. BIOLOGICAL PSYCHIATRY 67 (9), 183S-183S

    Association between GRIK2 Polymorphism and OCD: A Family-Based Study. J Crane, AS Sampaio, J Fagerness, D Hezel, M Leboyer, R Delorme, ...BIOLOGICAL PSYCHIATRY 65 (8), 57S-57S

    The Neural Correlates of Negative Priming in Pediatric Obsessive Compulsive Disorder. JC Britton, SE Stewart, LM Price, WDS Killgore, MA Jenike, SL Rauch. BIOLOGICAL PSYCHIATRY 65 (8),103S-103S

    Gender as a Mediator of Intensive Residential Treatment Response in OCD. DM Hezel, EA Jenike, A Sampaio, D EganStack, SE Stewart. BIOLOGICAL PSYCHIATRY 65 (8), 119S-119S

    Candidate Gene Association Study of DLGAP3 in Tourette Syndrome Patients. JM Scharf, J Crane, J Fagerness, B Gunnell, SE Stewart, DL Pauls. NEUROLOGY 72 (11), A40-A40

    Controlled family study of ADHD and Tourette's disorder. S Stewart, C Illmann, DA Geller, JF Leckman, R King, DL Pauls. AMERICAN JOURNAL OF MEDICAL GENETICS PART BNEUROPSYCHIATRIC GENETICS 138(1 ...)

    Tics and tourette’s disorder: Which therapies, and when to use them. ES Stewart, D Geller, T Spencer, L Gianini

    33 OCD and OCD-Related Disorders. SE Stewart, DD Dougherty, S Wilhelm, NJ Keuthen, MA Jenike

    Britton, JC, Rauch, SL, Rosso, IM, Killgore, WDS, Price, LM, Ragan, J, Chosak, A, Hezel, DM, Pine, DS, Leibenluft, E, Pauls, DL, Jenike, MA, Stewart, SE. Cognitive Inflexibility and Frontal-Cortical Activation in Pediatric Obsessive-Compulsive Disorder. J Am Acad Child Adolesc Psychiatry. 2010;49(9):944-953. (SA). PMID: 20732630.

    Britton, JC, Stewart, SE, Killgore, WDS, Rosso, IM, Price, LM, Gold, AL, Pine, DS, Wilhelm, S, Jenike, MA, Rauch, SL. Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder. Depr Anxiety. 2010;27(7):643-651. PMID: 20602430.

    Katerberg H, Delucchi KL, Stewart SE, Lochner C, Denys DA, Stack DE, Andresen JM, Grant JE, Kim SW, Williams KA, den Boer JA, van Balkom AJ, Smit JH, van Oppen P, Polman A, Jenike MA, Stein DJ, Mathews CA, Cath DC. Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates. Behavior Genetics. 2010;40(4):505-517. PMID: 20361247.

    Stewart SE, Jenike EA, Hezel DM, Egan Stack D, Dodman NH, Shuster L, Jenike MA. A Single-Blinded Case-Control Study of Memantine in Severe Obsessive-Compulsive Disorder. J Clin Psychopharmacol. 2010;30(1):34-9. (FA). PMID: 20075645.

    Schwartz CE, Kunwar PS, Greve DN, Moran LR, Viner JC, Covino JM, Kagan J, Stewart SE, Snidman NC, Vangel MG, Wallace SR. Structural differences in adult orbital and ventromedial prefrontal cortex are predicted by 4-month infant temperament. Arch Gen Psychiatry. 2010;67(1):78-84. (Journal ranking in psychiatry = 3, IF 13.77). PMID: 20048225.

    Stewart SE, Egan Stack D, Tsilker S, Alosso J, Stephansky M, Hezel DM, Jenike EA, Haddad SA, Kant J, Jenike MA. Long-term Outcome Following Intensive Residential Treatment of Obsessive-Compulsive Disorder. J Psych Research. 2009;43(13):1118-23. (FA). PMID: 19419736.

    Beattie KC, Hezel DM, Stewart SE. Trichotillomania-by-proxy: a possible cause of childhood alopecia. J Can Acad Child Adolesc Psychiatry; 2009;18(1):51-52. (SA). PMID: 19270849

    Novak CE, Keuthen NJ, Stewart SE, Pauls, DL. A twin concordance study of Trichotillomania. Am J Hum Genet B. 2009;150B:944-949. (SA). PMID: 19199280.

    Hezel DM, Beattie K, Stewart SE. Memantine as an augmenting agent for severe pediatric OCD. Am J Psychiatry; 2009;166(2):237. (SA). PMID: 19188297.

    Stewart SE, Rosario-Campos MC, Baer L, Carter A, Brown TA, Scharf JM, Illmann C, Leckman JF, Sukhodolsky D, Katsovitch L, Rasmussen S, Goodman W, Delorme R, Leboyer M, Chabane N, Jenike MA, Geller DA, Pauls DL. Four-Factor Structure of Obsessive-Compulsive Disorder Symptoms in Children, Adolescents and Adults. Journal of the American Academy of Child & Adolescent Psychiatry; 2008;47(7):763-72. (FA) (Journal ranking in child psychiatry = 1, IF 6.97). PMID: 18520961.

    Stewart SE, Beresin C, Haddad S, Egan Stack D, Fama J, Jenike MA. Predictors of Family Accommodation in Obsessive-Compulsive Disorder. Annals of Clinical Psychiatry; 2008;20:65-70. (FA). PMID: 18568577.

    Stewart SE, Egan Stack D, Wilhelm S. Severe Obsessive-Compulsive Disorder with and without Body Dysmorphic Disorder: Clinical Correlates and Implications. Ann Clin Psychiatry 2008;20:33-8. (FA). PMID: 18297584.

    Stewart SE, Fagerness J, Platko J, Smoller JW, Scharf J, Illmann C, Jenike E, Chabane N, Leboyer M, Delorme R, Jenike MA, Pauls DL. Association of the SLC1A1 Glutamate Transporter Gene and Obsessive-Compulsive Disorder. American Journal of Medical Genetics Part B 2007;144(8):1027-33. (FA). PMID: 17894418.

    Stewart SE, Platko J, Fagerness J, Birns J, Jenike E, Smoller JW, Perlis R, Leboyer M, Delorme R, Chabane N, Rauch SL, Jenike MA, Pauls DL. A Genetic Family-Based Association Study of OLIG2 in Obsessive-Compulsive Disorder. Arch Gen Psychiatry 2007;64(2):209-214. (FA) (Journal ranking in psychiatry = 3, IF 13.77). PMID: 17283288.

    Stewart SE**, Rosario-Campos MC**, Brown TA, Carter A, Geller DA, Leckman JF, Sukhodolsky D, Katsovitch L, Pauls DL. Principal Components Analysis of Obsessive Compulsive Disorder Symptoms in Children and Adolescents. Biol Psychiatry 2007;61(3):285-291. (co-FA) (Journal ranking in psychiatry 4, IF 9.25). PMID: 17161383.

    Stewart SE, Illmann C, Geller DA, Leckman JF, Scahill L, King R, Pauls DL. A Controlled Family Study of Attention Deficit Hyperactivity Disorder and Gilles de la Tourette’s Syndrome. J Am Acad Child Adolesc Psychiatry 2006;45(11): 1354-62. (FA) (Journal ranking in child psychiatry = 1, IF 6.97). PMID: 17075358.

    Stewart SE, Yen CH, Egan Stack D, Jenike MA. Outcome Predictors for Severe Obsessive-Compulsive Patients in Intensive Residential Treatment. J Psych Research 2006;40(6):511-9. (FA). PMID: 16229857.

    Stewart SE, Ceranoglu TA, O’Hanley T, Geller DA. Performance of clinician versus self-report measures to identify obsessive-compulsive disorder in children and adolescents. J Child Adolesc Psychopharmacol 2005;15(6):956-63. (FA). PMID: 16379516.

    Stewart SE, Egan-Stack D, Farrell C, Pauls DL, Jenike MA. Effectiveness of Intensive Residential Treatment (IRT) for Severe Refractory Obsessive-Compulsive Disorder. J Psych Research 2005;39:603-9. (FA). PMID: 16157162.

    Stewart SE, Jenike MA, Keuthen NJ. Severe Obsessive-Compulsive Disorder with and without Comorbid Hairpulling Comparisons and Clinical Implications. J Clin Psychiatry 2005;66(7):864-9. (FA). PMID: 16013902.

    Stewart SE, Geller DA, Jenike MA, Pauls D Shaw D, Mullin B, Faraone, SV. Long Term Outcome of Pediatric Obsessive Compulsive Disorder: A Meta-Analysis and Qualitative Review of the Literature. Acta Psychiatrica Scandinavica 2004;110(1):4-13. (FA). PMID:15180774.

    Geller DA, Biederman J, Stewart SE, Mullin B, Martin A, Spencer T, Faraone SV. Which SSRI? A Meta-Analysis of Pharmacotherapy Trials in Pediatric Obsessive-Compulsive Disorder. Am J Psychiatry 2003;160:1919-28. PMID: 14594734.

    Grants
    1. 2014-2016, CIHR Operating Grant, $175,485/year ($526,454 for 3 years), Neural Correlates in Childhood-onset Obsessive-Compulsive Disorder. The goal is to compare neural correlates in CO-OCD and unaffected, at-risk sibling (SIB) groups with matched healthy controls (HC), in order to evaluate both their suitability as trait markers of genetic risk (to better understand the disorder) and their potential utility in clinical settings (to better manage the disorder). Role: Principal Investigator.
    2. 2014-2015, CIHR Planning Grant, $25,000 (total), Establishing a Pediatric Obsessive Compulsive Disorder Research Network. The goal is to rapidly establish the first formal Canadian national network dedicated to research on Pediatric OCD, with a central aim of partnering researchers, stakeholders and decision-makers who will set priorities and develop a research plan that contributes to knowledge creation and knowledge translation addressing health system deficiencies with respect to pediatric OCD. Role: Principal Investigator.
    3. 2012-2020, MSFHR Clinical Research Scholar Award, $90,000/year or ($635,000 for 8 years), OCD translational multi-modal research program. The goal is to create an interdisciplinary, multimodal research program within the new Pediatric OCD clinic at B.C. Children’s Hospital. Role: Principal Investigator.
    4. 2010-current, NIH-RO1, Perspectives on Neuroimaging and Genetics from Parents of Children with OCD. The goal is to examine experiences of parents involved in Pediatric neuroimaging studies. Role: Co-Investigator.
    5. 2007-2014, Obsessive-Compulsive Foundation Genetics Collaborative Whole Genome Association Study. The goal is to conduct a whole genome association study to genotype 1 million single nucleotide polymorphisms along the DNA of 2500 OCD cases and their parents or controls. This is the first study of its kind to be conducted in OCD. Role: Co-Principal Investigator.
    Honours & Awards
    • 2009 Nominated for Excellence in Mentoring Award for 2008-2009, Massachusetts General Hospital
    • 2008-9 Travel Awardee American College of Neuropsychopharmacology
    • 2008 Research Colloquium for Junior Investigators
    • 2008 American Psychiatric Association
    • 2001 Resident nominee – Association of Chairs of Psychiatry of Canada Excellence in Research Award
    • 2001 Best Research Paper, Ottawa Psychiatry Resident Research Day
    • 2000 Best Resident Research Presentation, Ottawa Psychiatry Research Day
    • 2000 Resident nominee – Laughlin Fellowship
    • 2000 Best Canadian Child Psychiatry resident research project
    • 1999 Best Clinical Paper, Ottawa Pediatrics Resident Research Day
    • 1998 Chronic Care and Rehabilitation Award, Ottawa Resident Research Day
    • 1998 Wilson Fellowship Award
    • 1996 Inaugural Hunter Medical Humanities Award "for outstanding contribution demonstrating qualities of caring and compassion in the care of patients."
    • 1996 Silver D. Award for contribution to student life, Dalhousie University, Canada
    • 1994 Labe Scheinberg Award, Multiple Sclerosis Consortium, Minnesota
    • 1993 Marvin Burke Studentship, Addiction Medicine Conference, Vancouver
    • 1992 Federation of Medical Women of Canada Bursary
    Research Group Members
    • Dr. Joanna McDermitt- Child Psychiatrist 
    • Tracy Lau, B.A. - Administrative Assistant
    • Dr. Daniel Lafleur - Child Psychiatrist, Pedatric OCD
    • Dr. Christa Peters – Child Psychiatrist, Pediatric OCD
    • Dr. Katherine McKenney – Child Psychologist, Pediatric OCD Program
    • Dr. Annie Simpson – Child Psychologist, Pediatric OCD Program
    • Dr. Jamie Slaveg- Child Psychologist
    • Noel Gregorowski, MSW – Social Worker, Pediatric OCD Program
    • Dr, Fern Jaspers-Fayer – Neuroscience Postdoctoral Fellow, Pediatric OCD Program
    • David Schubert – Clinical Psychology Doctoral Candidate
    • Rachel Ferdman – Volunteer
    • Dr. Juliana Negreiros – School Psychologist and Postdoctoral Fellow
    • Dr. Robert Selles- Postdoctoral Psychology Fellow
    • Dr. Andrew Penin- Psychiatry Research Resident
    • Sarah Lin- Research Assistant
    • Laura Belschnen- Research Assistant