- Publications
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Spatial kinetics and immune control of murine cytomegalovirus infection in the salivary glands
PLOS Computational Biology
Catherine M Byrne and Ana Citlali Márquez and Bing Cai and Daniel Coombs and Soren Gantt
DOI: 10.1371/journal.pcbi.1011940
08/2024Longitudinal dynamics of the nasopharyngal microbiome in response to SARS-CoV-2 Omicron variant and HIV infection in Kenyan women and their infants
OpenAlex
DOI: 10.60692/c5qj1-vsn14
04/2024Machine learning-based approach KEVOLVE efficiently identifies SARS-CoV-2 variant-specific genomic signatures
PLOS ONE
Dylan Lebatteux and Hugo Soudeyns and Isabelle Boucoiran and Soren Gantt and Abdoulaye Baniré Diallo
DOI: 10.1371/journal.pone.0296627
01/2024Elevated binding and functional antibody responses to SARS-CoV-2 in infants versus mothers
OpenAlex
DOI: 10.60692/m92g8-76156
08/2023HIV and SARS-CoV-2 infection in postpartum Kenyan women and their infants
OpenAlex
DOI: 10.60692/2j5t2-x4h97
01/2023Genomic and geographical structure of human cytomegalovirus
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.2221797120
2023Identifying Clinical Criteria for an Expanded Targeted Approach to Screening for Congenital Cytomegalovirus Infection—A Retrospective Study
International Journal of Neonatal Screening
DOI: 10.3390/ijns9030040
2023Factors associated with severe acute respiratory syndrome-related coronavirus 2 infection in unvaccinated children and young adults
medRxiv
DOI: 10.1101/2023.08.13.23294036
2023Safety, efficacy, and immunogenicity of a replication-defective human cytomegalovirus vaccine, V160, in cytomegalovirus-seronegative women: a double-blind, randomised, placebo-controlled, phase 2b trial
The Lancet Infectious Diseases
DOI: 10.1016/S1473-3099(23)00343-2
2023Parent and healthcare provider views of live varicella vaccination of pediatric solid organ transplant recipients
Pediatric Transplantation
DOI: 10.1111/petr.14609
2023Newborn cytomegalovirus screening: is this the new standard?
Current opinion in otolaryngology & head and neck surgery
DOI: 10.1097/MOO.0000000000000925
2023Maternal vaginal microbiome composition does not affect development of the infant gut microbiome in early life
Frontiers in Cellular and Infection Microbiology
DOI: 10.3389/fcimb.2023.1144254
2023Comparison of nucleocapsid and spike antibody ELISAs for determining SARS-CoV-2 seropositivity in Kenyan women and infants
Journal of Medical Virology
Fish, C.S. and Owiti, P. and Begnel, E.R. and Itell, H.L. and Ojee, E. and Adhiambo, J. and Ogweno, V. and Holland, L.A. and Richardson, B.A. and Khan, A.K. and Maqsood, R. and Gantt, S. and Lim, E.S. and Slyker, J. and Kinuthia, J. and Overbaugh, J. and Wamalwa, D. and Lehman, D.A. and Chohan, B.H.
DOI: 10.1002/jmv.28221
2023Increased frequency and quantity of mucosal and plasma cytomegalovirus replication among Ugandan Adults Living with HIV
PLoS ONE
DOI: 10.1371/journal.pone.0287516
2023Vaccine value profile for cytomegalovirus
Vaccine
DOI: 10.1016/j.vaccine.2023.06.020
2023The cost-effectiveness of targeted screening for congenital cytomegalovirus in newborns compared to clinical diagnosis in the US
International Journal of Pediatric Otorhinolaryngology
Phillips, V.L. and Xu, J. and Park, A. and Gantt, S. and Dedhia, K.
DOI: 10.1016/j.ijporl.2023.111450
2023Age-Associated Seroprevalence of Coronavirus Antibodies: Population-Based Serosurveys in 2013 and 2020, British Columbia, Canada
Frontiers in Immunology
Tanunliong, G. and Liu, A.C. and Kaweski, S. and Irvine, M. and Reyes, R.C. and Purych, D. and Krajden, M. and Morshed, M. and Sekirov, I. and Gantt, S. and Skowronski, D.M. and Jassem, A.N.
DOI: 10.3389/fimmu.2022.836449
2022Persistence of Anti-SARS-CoV-2 Antibodies in Long Term Care Residents Over Seven Months After Two COVID-19 Outbreaks
Frontiers in Immunology
Tanunliong, G. and Liu, A. and Vijh, R. and Pidduck, T. and Kustra, J. and Márquez, A.C. and Choi, A. and McLennan, M. and Hayden, A. and Kearney, C. and Gantt, S. and Krajden, M. and Morshed, M. and Jassem, A.N. and Sekirov, I.
DOI: 10.3389/fimmu.2021.775420
2022Early-life cytomegalovirus infection is associated with gut microbiota perturbations and increased risk of atopy
Pediatric Allergy and Immunology
Sbihi, H. and Simmons, K.E. and Sears, M.R. and Moraes, T.J. and Becker, A.B. and Mandhane, P.J. and Subbarao, P. and Dai, D.L.Y. and Finlay, B.B. and Turvey, S.E. and Gantt, S.
DOI: 10.1111/pai.13658
2022A novel multiplex electrochemiluminescent immunoassay for detection and quantification of anti-SARS-CoV-2 IgG and anti-seasonal endemic human coronavirus IgG
Journal of Clinical Virology
Li, F.F. and Liu, A. and Gibbs, E. and Tanunliong, G. and Marquez, A.C. and Gantt, S. and Frykman, H. and Krajden, M. and Morshed, M. and Prystajecky, N.A. and Cashman, N. and Sekirov, I. and Jassem, A.N.
DOI: 10.1016/j.jcv.2021.105050
2022Modestly protective cytomegalovirus vaccination of young children effectively prevents congenital infection at the population level
medRxiv
DOI: 10.1101/2022.03.24.22272898
2022Distinct antibody responses to endemic coronaviruses pre- and post-SARS-CoV-2 infection in Kenyan infants and mothers
bioRxiv
DOI: 10.1101/2022.06.02.493651
2022KANALYZER: a method to identify variations of discriminative k-mers in genomic sequences
Proceedings - 2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022
Lebatteux, D. and Soudeyns, H. and Boucoiran, I. and Gantt, S. and Diallo, A.B.
DOI: 10.1109/BIBM55620.2022.9995370
2022Perinatal Cytomegalovirus Infection
Current Treatment Options in Pediatrics
Carmona, A.S. and Kakkar, F. and Gantt, S.
DOI: 10.1007/s40746-022-00261-y
2022Prevalence, incidence, and risk factors associated with cytomegalovirus infection in healthcare and childcare worker: a systematic review and meta-analysis
Systematic Reviews
Balegamire, S.J. and McClymont, E. and Croteau, A. and Dodin, P. and Gantt, S. and Besharati, A.A. and Renaud, C. and M{\^a}sse, B. and Boucoiran, I.
DOI: 10.1186/s13643-022-02004-4
2022Breast Milk Virome and Bacterial Microbiome Resilience in Kenyan Women Living with HIV
mSystems
Rabia Maqsood and Joshua B. Reus and Lily I. Wu and LaRinda A. Holland and Ruth Nduati and Dorothy Mbori-Ngacha and Elizabeth Maleche-Obimbo and Emily R. Begnel and Soren Gantt and Ednah Ojee and Dalton Wamalwa and Grace John-Stewart and Jennifer Slyker and Dara A. Lehman and Efrem S. Lim
DOI: 10.1128/msystems.01079-20
04/2021Perspectives of women on screening and prevention of CMV in pregnancy
European Journal of Obstetrics & Gynecology and Reproductive Biology
Meggie Lallier Beaudoin and Christian Renaud and Marc Boucher and Fatima Kakkar and Soren Gantt and Isabelle Boucoiran
DOI: 10.1016/j.ejogrb.2021.01.035
03/2021Frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec
PLoS ONE
Balegamire, S.J. and Renaud, C. and Masse, B. and Zinszer, K. and Gantt, S. and Giguere, Y. and Forest, J.-C. and Boucoiran, I.
DOI: 10.1371/journal.pone.0252309
2021Septic arthritis due to Mycoplasma orale in a young patient with hypogammaglobulinemia
JAMMI
Liu, A.C. and Harvey, M. and Lee, A. and Hildebrand, K. and Hoang, L. and Gantt, S. and Al-Rawahi, G.N.
DOI: 10.3138/JAMMI-2021-0002
2021Examining the dynamics of Epstein-Barr virus shedding in the tonsils and the impact of HIV-1 coinfection on daily saliva viral loads
PLoS Computational Biology
Byrne, C.M. and Johnston, C. and Orem, J. and Okuku, F. and Huang, M.-L. and Rahman, H. and Wald, A. and Corey, L. and Schiffer, J.T. and Casper, C. and Coombs, D. and Gantt, S.
DOI: 10.1371/journal.pcbi.1009072
2021Corrigendum dans la « Directive clinique no 420: Infection à cytomégalovirus pendant la grossesse » [J Obstet Gynaecol Can 43 (2021) 909-925] (Journal of Obstetrics and Gynaecology Canada (2021) 43(909-925) (S1701216321004448), (10.1016/j.jogc.2021.05.014))
Journal of Obstetrics and Gynaecology Canada
Boucoiran, I. and Yudin, M. and Poliquin, V. and Caddy, S. and Gantt, S. and Castillo, E.
DOI: 10.1016/j.jogc.2021.10.006
2021Maternal Epstein-Barr Virus-Specific Antibodies and Risk of Infection in Ugandan Infants
Journal of Infectious Diseases
Minab, R. and Bu, W. and Nguyen, H. and Wall, A. and Sholukh, A.M. and Huang, M.-L. and Ortego, M. and Krantz, E.M. and Irvine, M. and Casper, C. and Orem, J. and McGuire, A.T. and Cohen, J.I. and Gantt, S.
DOI: 10.1093/infdis/jiaa654
2021Guideline No. 420: Cytomegalovirus infection in pregnancy,Directive clinique no 420: Infection à cytomégalovirus pendant la grossesse
Journal of Obstetrics and Gynaecology Canada
Boucoiran, I. and Yudin, M. and Poliquin, V. and Caddy, S. and Gantt, S. and Castillo, E.
DOI: 10.1016/j.jogc.2021.05.014
2021Characterization of adaptive-like ¿d t cells in ugandan infants during primary cytomegalovirus infection
Viruses
Tuengel, J. and Ranchal, S. and Maslova, A. and Aulakh, G. and Papadopoulou, M. and Drissler, S. and Cai, B. and Mohsenzadeh-Green, C. and Soudeyns, H. and Mostafavi, S. and Elzen, P.D. and Vermijlen, D. and Cook, L. and Gantt, S.
DOI: 10.3390/v13101987
2021Importance of COVID-19 vaccine efficacy in older age groups
Vaccine
Sadarangani, M. and Abu Raya, B. and Conway, J.M. and Iyaniwura, S.A. and Falcao, R.C. and Colijn, C. and Coombs, D. and Gantt, S.
DOI: 10.1016/j.vaccine.2021.03.020
2021Early neonatal meconium does not have a demonstrable microbiota determined through use of robust negative controls with cpn60-based microbiome profiling
Microbiology Spectrum
Dos Santos, S.J. and Pakzad, Z. and Elwood, C.N. and Albert, A.Y.K. and Gantt, S. and Manges, A.R. and Dumonceaux, T.J. and Maan, E.J. and Hill, J.E. and Money, D.M.
DOI: 10.1128/Spectrum.00067-21
2021Corrigendum to ‘Guideline No. 420: Cytomegalovirus Infection in Pregnancy’ [Journal of Obstetrics and Gynaecology Canada 43/7 (2021) 893-908] (Journal of Obstetrics and Gynaecology Canada (2021) 43/7(893-908) (S170121632100445X), (10.1016/j.jogc.2021.05.015))
Journal of Obstetrics and Gynaecology Canada
Boucoiran, I. and Yudin, M. and Poliquin, V. and Caddy, S. and Gantt, S. and Castillo, E.
DOI: 10.1016/j.jogc.2021.09.004
2021Pneumococcal vaccination during chemotherapy in children treated for acute lymphoblastic leukemia
Pediatric Blood and Cancer
Dorval, S. and Gantt, S. and Leclerc, J.-M. and Laverdière, C. and Ovetchkine, P. and Tapiéro, B.
DOI: 10.1002/pbc.28944
2021Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants
Journal of Leukocyte Biology
Kidzeru, E. and Gasper, M.A. and Shao, D. and Edlefsen, P.T. and Lejarcegui, N. and Havyarimana, E. and Urdahl, K. and Gantt, S. and Horton, H. and Jaspan, H. and Gervassi, A.
DOI: 10.1002/JLB.5A0420-281R
2021Immunogenicity and safety of a tri-antigenic versus a mono-antigenic hepatitis B vaccine in adults (PROTECT): a randomised, double-blind, phase 3 trial
The Lancet Infectious Diseases
Vesikari, T. and Langley, J.M. and Segall, N. and Ward, B.J. and Cooper, C. and Poliquin, G. and Smith, B. and Gantt, S. and McElhaney, J.E. and Dionne, M. and van Damme, P. and Leroux-Roels, I. and Leroux-Roels, G. and Machluf, N. and Spaans, J.N. and Yassin-Rajkumar, B. and Anderson, D.E. and Popovic, V. and Diaz-Mitoma, F. and McElhaney, J. and Rankin, B. and Griffin, C. and Turner, M. and Kirstein, J. and Rizzardi, B.E. and Williams, H. and Ahonen, A. and Henriksson, O. and Ukkonen, B. and Paassilta, M.
DOI: 10.1016/S1473-3099(20)30780-5
2021Guideline No. 420: Cytomegalovirus Infection in Pregnancy
Journal of Obstetrics and Gynaecology Canada
Boucoiran, I. and Yudin, M. and Poliquin, V. and Caddy, S. and Gantt, S. and Castillo, E.
DOI: 10.1016/j.jogc.2021.05.015
2021Mixed cytomegalovirus genotypes in HIV-positive mothers show compartmentalization and distinct patterns of transmission to infants
OpenAlex
DOI: 10.60692/r71xw-fg913
12/2020Waning vaccine immunity and vaccination responses in children treated for acute lymphoblastic leukemia: A Canadian Immunization Research Network Study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Top KA and Vaudry W and Morris SK and Pham-Huy A and Pernica JM and Tapiéro B and Gantt S and Price VE and Rassekh SR and Sung L and McConnell A and Rubin E and Chawla R and Halperin SA
DOI: 10.1093/cid/ciaa163
PubMed: 32067048
02/2020Mixed cytomegalovirus genotypes in HIV positive mothers show compartmentalization and distinct patterns of transmission to infants.
medRxiv
Pang, J. and Slyker, J.A. and Roy, S. and Bryant, J. and Atkinson, C. and Cudini, J. and Farquhar, C. and Griffiths, P. and Kiarie, J. and Morfopoulou, S. and Roxby, A.C. and Tutil, H. and Williams, R. and Gantt, S. and Goldstein, R.A. and Breuer, J.
DOI: 10.1101/2020.09.17.20196790
2020Challenges in evaluating SARS-CoV-2 vaccines during the COVID-19 pandemic,Difficultés associées à l’évaluation des vaccins contre le SRAS-CoV-2 pendant la pandémie de COVID-19
CMAJ
Abu-Raya, B. and Gantt, S. and Sadarangani, M.
DOI: 10.1503/CMAJ.201237-F
2020Valganciclovir prophylaxis delays onset of EBV viremia in high-risk pediatric solid organ transplant recipients
Pediatric Research
Albatati, S. and Sharma, A. and Haubrich, K. and Wright, A. and Gantt, S. and Blydt-Hansen, T.D.
DOI: 10.1038/s41390-019-0523-4
2020Performance of the ALethia CMV assay for detection of cytomegalovirus by use of neonatal saliva swabs
Journal of Clinical Microbiology
Gantt, S. and Goldfarb, D.M. and Park, A. and Rawlinson, W. and Boppana, S.B. and Lazzarotto, T. and Mertz, L.M.
DOI: 10.1128/JCM.01951-19
2020Challenges in evaluating SARS-CoV-2 vaccines during the COVID-19 pandemic
CMAJ
Abu-Raya, B. and Gantt, S. and Sadarangani, M.
DOI: 10.1503/cmaj.201237
2020Mixed cytomegalovirus genotypes in HIV positive mothers show compartmentalization and distinct patterns of transmission to infants
eLife
Pang, J. and Slyker, J.A. and Roy, S. and Bryant, J. and Atkinson, C. and Cudini, J. and Farquhar, C. and Griffiths, P. and Kiarie, J. and Morfopoulou, S. and Roxby, A.C. and Tutil, H. and Williams, R. and Gantt, S. and Goldstein, R.A. and Breuer, J.
DOI: 10.7554/ELIFE.63199
2020Estimating the risk of human herpesvirus 6 and cytomegalovirus transmission to ugandan infants from viral shedding in saliva by household contacts
Viruses
Mayer, B.T. and Krantz, E.M. and Wald, A. and Corey, L. and Casper, C. and Gantt, S. and Schiffer, J.T.
DOI: 10.3390/v12020171
2020Randomized trial of 2 schedules of meningococcal B vaccine in adolescents and young adults, Canada
Emerging Infectious Diseases
Langley, J.M. and Gantt, S. and Quach, C. and Bettinger, J.A. and Halperin, S.A. and Mutch, J. and McNeil, S.A. and Ward, B.J. and MacKinnon-Cameron, D. and Ye, L. and Marty, K. and Scheifele, D. and Brown, E. and Alcantara, J.
DOI: 10.3201/eid2603.190160
2020Increased oral Epstein-Barr virus shedding with HIV-1 co-infection is due to a combination of B cell activation and impaired cellular immune control
Byrne CM and Johnston C and Orem J and Okuku F and Huang M and Selke S and Wald A and Corey L and Schiffer JT and Casper C and Coombs D and Gantt S
DOI: 10.1101/587063
03/2019Anti-factor H antibody reactivity in young adults vaccinated with a meningococcal serogroup B vaccine containing factor H binding protein
mSphere
Sharkey, K. and Beernink, P.T. and Langley, J.M. and Gantt, S. and Quach, C. and Dold, C. and Liu, Q. and Galvan, M. and Granoff, D.M.
DOI: 10.1128/mSphere.00393-19
2019AMMI Canada: Response to FAQs about the management of children with congenital cytomegalovirus infection in Canada
JAMMI
Gantt, S. and Brophy, J. and Dunn, J. and Vaudry, W. and Bitnun, A. and Renaud, C. and Kakkar, F.
DOI: 10.3138/jammi.2019-08-21
2019Humoral immune correlates for prevention of postnatal cytomegalovirus acquisition
Journal of Infectious Diseases
Saccoccio, F.M. and Jenks, J.A. and Itell, H.L. and Li, S.H. and Berry, M. and Pollara, J. and Casper, C. and Gantt, S. and Permar, S.R.
DOI: 10.1093/infdis/jiz192
2019LB18. An Enveloped Virus-like Particle (eVLP) Cytomegalovirus (CMV) Vaccine Is Immunogenic and Safe: Results of a First-in-Humans Study.
Open forum infectious diseases
Gantt S and Quach C and Anderson DE and Diaz-Mitoma F and Langley J
DOI: 10.1093/ofid/ofy229.2192
11/2018116. Role of Maternal Antibodies in Protection Against Postnatal Cytomegalovirus Acquisition.
Open Forum Infectious Diseases
Saccoccio F and Itell H and Li S and Jenks J and Xie G and Pollara J and Gantt S and Permar S
DOI: 10.1093/ofid/ofy209.007
11/2018Herpes simplex Virus
Oxford Medicine Online
Raidan Alyazidi and Soren Gantt
DOI: 10.1093/med/9780190604813.003.0007
01/2018Recovery of cytomegalovirus DNA from newborn saliva samples by different methods
Journal of Clinical Virology
Goshen, O. and Goldfarb, D.M. and Book, L. and Tilley, P. and Gantt, S.
DOI: 10.1016/j.jcv.2018.05.001
2018Nonprimary Maternal Cytomegalovirus Infection After Viral Shedding in Infants
The Pediatric infectious disease journal
Boucoiran, I. and Mayer, B.T. and Krantz, E.M. and Marchant, A. and Pati, S. and Boppana, S. and Wald, A. and Corey, L. and Casper, C. and Schiffer, J.T. and Gantt, S.
DOI: 10.1097/INF.0000000000001877
2018The potential harm of cytomegalovirus infection in immunocompetent critically ill children
Frontiers in Pediatrics
Alyazidi, R. and Murthy, S. and Slyker, J.A. and Gantt, S.
DOI: 10.3389/fped.2018.00096
2018Real-time Detection and Monitoring of Loop Mediated Amplification (LAMP) Reaction Using Self-quenching and De-quenching Fluorogenic Probes
Scientific Reports
Gadkar, V.J. and Goldfarb, D.M. and Gantt, S. and Tilley, P.A.G.
DOI: 10.1038/s41598-018-23930-1
2018Successful treatment of chronic norovirus gastroenteritis with nitazoxanide in a pediatric kidney transplant recipient
Pediatric Transplantation
Haubrich, K. and Gantt, S. and Blydt-Hansen, T.
DOI: 10.1111/petr.13186
2018Natural history of postnatal rhesus cytomegalovirus shedding by dams and acquisition by infant rhesus monkeys
PLoS ONE
Kaur, A. and Itell, H.L. and Ehlinger, E.P. and Varner, V. and Gantt, S. and Permar, S.R.
DOI: 10.1371/journal.pone.0206330
2018In reference to should infants who fail their newborn hearing screen undergo cytomegalovirus testing?
Laryngoscope
Gantt, S. and Goldfarb, D.M. and Dionne, F. and Bulman, D. and Doutré, S.M.
DOI: 10.1002/lary.27032
2018Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6
BMC Genomics
Greninger, A.L. and Knudsen, G.M. and Roychoudhury, P. and Hanson, D.J. and Sedlak, R.H. and Xie, H. and Guan, J. and Nguyen, T. and Peddu, V. and Boeckh, M. and Huang, M.-L. and Cook, L. and Depledge, D.P. and Zerr, D.M. and Koelle, D.M. and Gantt, S. and Yoshikawa, T. and Caserta, M. and Hill, J.A. and Jerome, K.R.
DOI: 10.1186/s12864-018-4604-2
2018Kshv oral shedding and plasma viremia result in significant changes in the extracellular tumorigenic miRNA expression profile in individuals infected with the malaria parasite
PLoS ONE
Ikoma, M. and Gantt, S. and Casper, C. and Ogata, Y. and Zhang, Q. and Basom, R. and Dyen, M.R. and Rose, T.M. and Barcy, S.
DOI: 10.1371/journal.pone.0192659
2018Higher expectations for a vaccine to prevent congenital cytomegalovirus infection
Journal of Virology
Gantt, S. and Marchant, A. and Boppana, S.B.
DOI: 10.1128/JVI.00764-18
2018Effects of spatiotemporal HSV-2 lesion dynamics and antiviral treatment on the risk of HIV-1 acquisition
PLoS Computational Biology
Byrne, C.M. and Gantt, S. and Coombs, D.
DOI: 10.1371/journal.pcbi.1006129
2018Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants
AIDS
Beima-Sofie, K. and Wamalwa, D. and Maleche-Obimbo, E. and Lingappa, J.R. and Mackelprang, R. and Gantt, S. and John-Stewart, G. and Casper, C. and Slyker, J.A.
DOI: 10.1097/QAD.0000000000001680
2018Genomic and proteomic analysis of Human herpesvirus 6 reveals distinct clustering of acute versus inherited forms and reannotation of reference strain
Greninger AL and Knudsen GM and Roychoudhury P and Hanson DJ and Sedlak RH and Xie H and Guan J and Nguyen T and Peddu V and Boeckh M and Huang M and Cook L and Depledge DP and Zerr DM and Jerome KR
DOI: 10.1101/181248
08/2017Reply to "Early stochastic dynamics in human cytomegalovirus infection"
Journal of Virology
Gantt, S. and Mayer, B.T. and Schiffer, J.T.
DOI: 10.1128/JVI.01006-17
2017Transient oral human cytomegalovirus infections indicate inefficient viral spread from very few initially infected cells
Journal of Virology
Mayer, B.T. and Krantz, E.M. and Swan, D. and Ferrenberg, J. and Simmons, K. and Selke, S. and Huang, M.-L. and Casper, C. and Corey, L. and Wald, A. and Schiffer, J.T. and Gantt, S.
DOI: 10.1128/JVI.00380-17
2017Diagnosis and management of infants with congenital cytomegalovirus infection
Paediatrics and Child Health (Canada)
Gantt, S. and Bitnun, A. and Renaud, C. and Kakkar, F. and Vaudry, W.
DOI: 10.1093/pch/pxx002
2017Virus and host-specific differences in oral human herpesvirus shedding kinetics among Ugandan women and children
Scientific Reports
Matrajt, L. and Gantt, S. and Mayer, B.T. and Krantz, E.M. and Orem, J. and Wald, A. and Corey, L. and Schiffer, J.T. and Casper, C.
DOI: 10.1038/s41598-017-12994-0
2017Diagnosis and management of congenital cytomegalovirus infection
This Changed My Practice
06/2016Dynamics of persistent oral cytomegalovirus shedding during primary infection in ugandan infants
Journal of Infectious Diseases
Mayer, B.T. and Matrajt, L. and Casper, C. and Krantz, E.M. and Corey, L. and Wald, A. and Gantt, S. and Schiffer, J.T.
DOI: 10.1093/infdis/jiw442
2016Symptomatic Congenital Cytomegalovirus Infection Is Underdiagnosed in British Columbia
Journal of Pediatrics
Sorichetti, B. and Goshen, O. and Pauwels, J. and Kozak, F.K. and Tilley, P. and Krajden, M. and Gantt, S.
DOI: 10.1016/j.jpeds.2015.10.069
2016Cost-effectiveness of universal and targeted newborn screening for congenital cytomegalovirus infection
JAMA Pediatrics
Gantt, S. and Dionne, F. and Kozak, F.K. and Goshen, O. and Goldfarb, D.M. and Park, A.H. and Boppana, S.B. and Fowler, K.
DOI: 10.1001/jamapediatrics.2016.2016
2016Authors reply
British Columbia Medical Journal
Roberts, A. and Gantt, S. and Ng, K. and Paquette, V. and Kang, K.
2016Risk of congenital cytomegalovirus infection among HIV-exposed uninfected infants is not decreased by maternal nelfinavir use during pregnancy
Journal of Medical Virology
Gantt, S. and Leister, E. and Jacobsen, D.L. and Boucoiran, I. and Huang, M..-L. and Jerome, K.R. and Jourdain, G. and Ngo-Giang-Huong, N. and Burchett, S. and Frenkel, L.
DOI: 10.1002/jmv.24420
2016Bacillus pumilus Septic Arthritis in a Healthy Child
Canadian Journal of Infectious Diseases and Medical Microbiology
Shivamurthy, V.M. and Gantt, S. and Reilly, C. and Tilley, P. and Guzman, J. and Tucker, L.
DOI: 10.1155/2016/3265037
2016Patterns of human herpesvirus-8 oral shedding among diverse cohorts of human herpesvirus-8 seropositive persons
Infectious Agents and Cancer
Bender Ignacio, R.A. and Goldman, J.D. and Magaret, A.S. and Selke, S. and Huang, M.-L. and Gantt, S. and Johnston, C. and Phipps, W.T. and Schiffer, J.T. and Zuckerman, R.A. and McClelland, R.S. and Celum, C. and Corey, L. and Wald, A. and Casper, C.
DOI: 10.1186/s13027-016-0052-2
2016Prospective Characterization of the Risk Factors for Transmission and Symptoms of Primary Human Herpesvirus Infections among Ugandan Infants
Journal of Infectious Diseases
Gantt, S. and Orem, J. and Krantz, E.M. and Morrow, R.A. and Selke, S. and Huang, M.-L. and Schiffer, J.T. and Jerome, K.R. and Nakaganda, A. and Wald, A. and Casper, C. and Corey, L.
DOI: 10.1093/infdis/jiw076
2016Recommended curriculum for training in pediatric transplant infectious diseases
Journal of the Pediatric Infectious Diseases Society
Danziger-Isakov, L. and Allen, U. and Englund, J. and Herold, B. and Hoffman, J. and Green, M. and Gantt, S. and Kumar, D. and Michaels, M.G.
DOI: 10.1093/jpids/pit079
2015Nelfinavir impairs glycosylation of herpes simplex virus 1 envelope proteins and blocks virus maturation
Advances in Virology
Gantt, S. and Gachelet, E. and Carlsson, J. and Barcy, S. and Casper, C. and Lagunoff, M.
DOI: 10.1155/2015/687162
2015Bacillus Pumilus; A Rare Cause of Paediatric Septic Arthritis. A Case Report
JOURNAL OF RHEUMATOLOGY
2015Management of influenza infection in children and pregnant women in BC, an update
British Columbia Medical Journal
Ng, K. and Paquette, V. and Kang, K.T. and Gantt, S. and Roberts, A.
2015Development of Online Branched Learning Modules in Pediatric Transplant Infectious Diseases
Open Forum Infectious Diseases
Bernhard Wiedermann and Monica I. Ardura and Lara Danziger-Isakov and Soren Gantt and Blanca E Gonzalez and Tanvi Sharma
DOI: 10.1093/ofid/ofv133.314
2015Breast milk transmission of nevirapine-resistant HIV-1 to infants after single-dose nevirapine in Beira, Mozambique
Journal of Infectious Diseases
2014Transmission of nevirapine-resistant HIV type 1 via breast milk to infants after single-dose nevirapine in Beira, Mozambique
Journal of Infectious Diseases
Micek, M.A. and Dross, S. and Blanco, A.J. and Beck, I.A. and Matunha, L. and Seidel, K. and Montoya, P. and Matediana, E. and Gantt, S. and Gloyd, S. and Frenkel, L.
DOI: 10.1093/infdis/jiu130
2014The role of myeloid-derived suppressor cells in immune ontogeny
Frontiers in Immunology
Gantt, S. and Gervassi, A. and Jaspan, H. and Horton, H.
DOI: 10.3389/fimmu.2014.00387
2014Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro t cell responses
PLoS ONE
Gervassi, A. and Lejarcegui, N. and Dross, S. and Jacobson, A. and Itaya, G. and Kidzeru, E. and Gantt, S. and Jaspan, H. and Horton, H.
DOI: 10.1371/journal.pone.0107816
2014Acute flaccid paralysis in a child infected with enterovirus D68: A case report
British Columbia Medical Journal
Sherwood, M.D. and Gantt, S. and Connolly, M. and Dobson, S.
2014Reduced human herpesvirus-8 oropharyngeal shedding associated with protease inhibitor-based antiretroviral therapy
Journal of Clinical Virology
Gantt, S. and Cattamanchi, A. and Krantz, E. and Magaret, A. and Selke, S. and Kuntz, S.R. and Huang, M.-L. and Corey, L. and Wald, A. and Casper, C.
DOI: 10.1016/j.jcv.2014.03.002
2014An artesunate-containing antimalarial treatment regimen did not suppress cytomegalovirus viremia
Journal of Clinical Virology
Gantt, S. and Huang, M.-L. and Magaret, A. and Bunts, L. and Selke, S. and Wald, A. and Rosenthal, P.J. and Dorsey, G. and Casper, C.
DOI: 10.1016/j.jcv.2013.06.008
2013Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and prevention
Current Opinion in Oncology
Gantt, S. and Casper, C. and Ambinder, R.F.
DOI: 10.1097/CCO.0b013e328363dfee
2013Implications of age-dependent immune responses to enterovirus 71 infection for disease pathogenesis and vaccine design
Journal of the Pediatric Infectious Diseases Society
Gantt, S. and Yao, L. and Kollmann, T.R. and Casper, C. and Zhang, J. and Self, S.G.
DOI: 10.1093/jpids/pit017
2013The immunologic basis for severe neonatal herpes disease and potential strategies for therapeutic intervention
Clinical and Developmental Immunology
Gantt, S. and Muller, W.J.
DOI: 10.1155/2013/369172
2013Valganciclovir dosing using area under the curve calculations in pediatric solid organ transplant recipients
Pediatric Transplantation
Villeneuve, D. and Brothers, A. and Harvey, E. and Kemna, M. and Law, Y. and Nemeth, T. and Gantt, S.
DOI: 10.1111/petr.12030
2013Human herpesvirus 6, 7 and 8 in solid organ transplantation
American Journal of Transplantation
Le, J. and Gantt, S.
DOI: 10.1111/ajt.12106
2013Early Life Immunity and Ability to Respond to Vaccines Hindered by Myeloid Derived Suppressor Cells: Implications for Infant HIV Vaccinology
AIDS RESEARCH AND HUMAN RETROVIRUSES
2013Effects of short-course zidovudine on the selection of nevirapine-resistant HIV-1 in women taking single-dose nevirapine
Journal of Infectious Diseases
Micek, M.A. and Blanco, A.J. and Carlsson, J. and Beck, I.A. and Dross, S. and Matunha, L. and Seidel, K. and Montoya, P. and Gantt, S. and Matediana, E. and Jamisse, L. and Gloyd, S. and Frenkel, L.M.
DOI: 10.1093/infdis/jis282
2012Nevirapine-resistant HIV-1 DNA in breast milk after single-dose nevirapine with or without zidovudine for prevention of mother-to-child transmission
Journal of the Pediatric Infectious Diseases Society
Gantt, S. and Payant, R. and Carlsson, J. and Micek, M.A. and Blanco, A.J. and Beck, I.A. and Matunha, L. and Montoya, P. and Matediana, E. and Gloyd, S. and Frenkel, L.M.
DOI: 10.1093/jpids/pis065
2012Central venous catheter repair is associated with an increased risk of bacteremia and central line-associated bloodstream infection in pediatric patients
Pediatric Infectious Disease Journal
Lundgren, I.S. and Zhou, C. and Malone, F.R. and McAfee, N.G. and Gantt, S. and Zerr, D.M.
DOI: 10.1097/INF.0b013e31823eeec5
2012Human herpesvirus 8-associated neoplasms: The roles of viral replication and antiviral treatment
Current Opinion in Infectious Diseases
Gantt, S. and Casper, C.
DOI: 10.1097/QCO.0b013e3283486d04
2011Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump
International Journal of Antimicrobial Agents
Qin, X. and Poon, B. and Kwong, J. and Niles, D. and Schmidt, B.Z. and Rajagopal, L. and Gantt, S.
DOI: 10.1016/j.ijantimicag.2011.03.007
2011The HIV protease inhibitor nelfinavir inhibits Kaposi's sarcoma-associated herpesvirus replication in vitro
Antimicrobial Agents and Chemotherapy
Gantt, S. and Carlsson, J. and Ikoma, M. and Gachelet, E. and Gray, M. and Geballe, A.P. and Corey, L. and Casper, C. and Lagunoff, M. and Vieira, J.
DOI: 10.1128/AAC.01295-10
2011Nevirapine resistance by timing of HIV type 1 infection in infants treated with single-dose nevirapine
Clinical Infectious Diseases
Micek, M.A. and Blanco, A.J. and Beck, I.A. and Dross, S. and Matunha, L. and Montoya, P. and Seidel, K. and Gantt, S. and Matediane, E. and Jamisse, L. and Gloyd, S. and Frenkel, L.M.
DOI: 10.1086/652151
2010Genetic analyses of HIV-1 env sequences demonstrate limited compartmentalization in breast milk and suggest viral replication within the breast that increases with mastitis
Journal of Virology
Gantt, S. and Carlsson, J. and Heath, L. and Bull, M.E. and Shetty, A.K. and Mutsvangwa, J. and Musingwini, G. and Woelk, G. and Zijenah, L.S. and Katzenstein, D.A. and Mullins, J.I. and Frenkel, L.M.
DOI: 10.1128/JVI.00543-10
2010Outcomes from pandemic influenza A H1N1 infection in recipients of solid-organ transplants: A multicentre cohort study
The Lancet Infectious Diseases
Kumar, D. and Michaels, M.G. and Morris, M.I. and Green, M. and Avery, R.K. and Liu, C. and Danziger-Isakov, L. and Stosor, V. and Estabrook, M. and Gantt, S. and Marr, K.A. and Martin, S. and Silveira, F.P. and Razonable, R.R. and Allen, U.D. and Levi, M.E. and Lyon, G.M. and Bell, L.E. and Huprikar, S. and Patel, G. and Gregg, K.S. and Pursell, K. and Helmersen, D. and Julian, K.G. and Shiley, K. and Bono, B. and Dharnidharka, V.R. and Alavi, G. and Kalpoe, J.S. and Shoham, S. and Reid, G.E. and Humar, A.
DOI: 10.1016/S1473-3099(10)70133-X
2010Clinical presentation and outcome of epidemic Kaposi sarcoma in Ugandan children
Pediatric Blood and Cancer
Gantt, S. and Kakuru, A. and Wald, A. and Walusansa, V. and Corey, L. and Casper, C. and Orem, J.
DOI: 10.1002/pbc.22369
2010Intermittent preventive treatment using artemisinin-based combination therapy reduces malaria morbidity among school-aged children in Mali
Tropical Medicine and International Health
Barger, B. and Maiga, H. and Traore, O.B. and Tekete, M. and Tembine, I. and Dara, A. and Traore, Z.I. and Gantt, S. and Doumbo, O.K. and Djimde, A.A.
DOI: 10.1111/j.1365-3156.2009.02294.x
2009Cytomegalovirus and Epstein-Barr virus in breast milk are associated with HIV-1 shedding but not with mastitis
AIDS
Gantt, S. and Carlsson, J. and Shetty, A.K. and Seidel, K.D. and Qin, X. and Mutsvangwa, J. and Musingwini, G. and Woelk, G. and Zijenah, L.S. and Katzenstein, D.A. and Frenkel, L.M.
DOI: 10.1097/QAD.0b013e32830184f2
2008Laboratory indicators of mastitis are not associated with elevated HIV-1 DNA loads or predictive of HIV-1 RNA loads in breast milk
Journal of Infectious Diseases
Gantt, S. and Shetty, A.K. and Seidel, K.D. and Matasa, K. and Musingwini, G. and Woelk, G. and Zijenah, L.S. and Katzenstein, D.A. and Frenkel, L.M.
DOI: 10.1086/519843
2007Use of 16S ribosomal DNA polymerase chain reaction to identify Haemophilus influenzae type B as the etiology of pericarditis in an infant [5]
Pediatric Infectious Disease Journal
Benson, C. and Gantt, S. and Zerr, D.M. and Qin, X. and Abe, P.
DOI: 10.1097/01.inf.0000154593.22356.e2
2005Levels of circumsporozoite protein in the Plasmodium oocyst determine sporozoite morphology
EMBO Journal
Thathy, V. and Fujioka, H. and Gantt, S. and Nussenzweig, R. and Nussenzweig, V. and Ménard, R.
DOI: 10.1093/emboj/21.7.1586
2002Antibodies against thrombospondin-related anonymous protein do not inhibit Plasmodium sporozoite infectivity in vivo
Infection and Immunity
Gantt, S. and Persson, C. and Rose, K. and Birkett, A.J. and Abagyan, R. and Nussenzweig, V.
DOI: 10.1128/IAI.68.6.3667-3673.2000
2000Conservation of a gliding motility and cell invasion machinery in Apicomplexan parasites
Journal of Cell Biology
Kappe, S. and Bruderer, T. and Gantt, S. and Fujioka, H. and Nussenzweig, V. and Ménard, R.
DOI: 10.1083/jcb.147.5.937
1999Proteasome inhibitors block development of Plasmodium spp.
Antimicrobial Agents and Chemotherapy
Gantt, S.M. and Myung, J.M. and Briones, M.R.S. and Li, W.D. and Corey, E.J. and Omura, S. and Nussenzweig, V. and Sinnis, P.
DOI: 10.1128/aac.42.10.2731
1998Cell adhesion to a motif shared by the malaria circumsporozoite protein and thrombospondin is mediated by its glycosaminoglycan-binding region and not by CSVTCG
Journal of Biological Chemistry
Gantt, S.M. and Clavijo, P. and Bai, X. and Esko, J.D. and Sinnis, P.
DOI: 10.1074/jbc.272.31.19205
1997 - Research
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Current Projects
Infections with human herpesviruses (HHVs), such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), and Kaposi's sarcoma-associated herpesvirus (KSHV), cause an enormous amount of morbidity and mortality worldwide. Although nearly everyone becomes infected with one or more of these viruses, most have no significant illness from them. However, in young infants or people immunocompromised by HIV or having a transplant, these viruses frequently cause a range of severe infections and cancers. Vaccines or drugs to prevent these infections or their complications would have profound public health implications, but first additional research is required to better understand the underlying pathogenesis. As such, we carry out translational research studies, utilizing cohorts of children in Africa and North America as well as epidemiologic, clinical, and molecular approaches, to address fundamental questions about how to prevent and treat HHV-related diseases.
We are particularly interested in the role of HHV infections very early in life. For example, CMV infects approximately 1% of all infants in utero, which frequently results in neurologic sequelae like deafness and mental retardation; postnatal infections, however, are normally benign. Similarly, high risk for Burkitt's lymphoma, one of the most common childhood cancers in Africa, appears to be due to EBV infection in early infancy combined with exposure to malaria. We have established a cohort of children in Uganda who were followed every week during the first year of life to study CMV and EBV infection. The precise timing of infection with these viruses was established by weekly PCR testing. Comprehensive data were collected regarding epidemiologic and biologic risks of acquisition, including detailed behavioral questionnaires, determination of the viral exposure by household contacts, and collection of blood for measurement of virus-specific neutralizing maternal antibodies. Symptoms of illness associated with infection were captured using standardized physical exams and clinical histories, and blood was collected to evaluate the humoral and cellular immune responses to these viruses that are associated with control of viral replication.
Another recent focus of our group has been to elucidate the mechanism of action of the HIV protease inhibitor (PI) nelfinavir to inhibit HHV replication, and investigate the drug's potential to prevent and treat HHV-related diseases. We discovered that nelfinavir is able to block in vitro replication of all HHVs tested to date, at concentrations that are achieved in patients taking doses that are FDA-approved for treatment of HIV. This activity is unique to nelfinavir among PIs, and appears to result from effects of nelfinavir on host cell pathways that are required for viral replication, rather than on the virus itself. Interestingly, at least some of these cellular effects also confer nelfinavir's increasingly appreciated antitumor activities. Because nelfinavir is safe for use in humans, we have undertaken a phase 1/2 trial of nelfinavir for the treatment of Kaposi's sarcoma in Africa and the US. In addition, because nelfinavir is also safe during pregnancy, we are testing whether nelfinavir given to HIV-infected women during pregnancy can prevent congenital CMV infection.GrantsCIHR Operating Grant - Project: "Correlates of acquisition and immune control of primary Epstein-Barr virus infection in Ugandan infants" – 2014-19
P01 Project: “Immune Control of KSHV Infection and Impact of HIV Infection And Therapy”
NIH (Co-PIs: Soren Gantt and Serge Barcy) 03/01/11 – 02/29/16
Honours & AwardsSigma Xi Society, 1993
Honors for Undergraduate Research, Brown University, 1993
Rosenbluth Foundation Travel Award, 1999
Little-known virus is a major cause of childhood hearing loss
We caught up with Dr. Soren Gantt, pediatric infectious disease specialist and director of clinical research at BC Children’s Hospital, about a little-known virus that is a major source of childhood hearing loss.
