• Kollmann, Tobias R.

    Titles

    Investigator, BC Children's Hospital
    Professor, Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia
    Pediatric Infectious Disease Consultant, BC Children's Hospital
    Senior Clinician Scientist, BC Children's Hospital Research

    Degrees / Designations
    MD, PhD
    Primary Area of Research
    Healthy Starts
    Secondary Area(s) of Research
    Phone
    604-875-2466
    Fax
    604-875-2226
    Lab Phone
    604-875-5986
    Assistant
    Dr. Cai Bing
    Mailing Address

    BC Children's Hospital Research Institute

    Room A5- 175

    950 West 28th Avenue

    Vancouver, BC V5Z 4H4

    Research Areas
    • Immunology and immunological diseases

    • Developmental immunology/ neonatal immunology

    • Infectious disease

    • Vaccines

    Summary

    As you read this paragraph, two infants in the world will have died from an infection for which there is an effective vaccine. Worldwide we could save millions of infants every year - if only we could immunize them on time. The work in our lab focuses on part of the science to help solve this problem.

    Current Projects

    Our lab uses state-of-the-art wet-lab technology and bioinformatic approaches (systems biology) to get the most information out of the smallest samples from newborns and infants around the world. Parallel to these obervational human cohort studies, we are developing in vitro (culture) and in vivo (animal) models where we establish concrete cause & effect of the relationships identified in our systems biological studies. This combined approach allows us to systematically dissect the key cellular and molecular mechanisms important in the human neonatal and infant response to infection or vaccination. Based on that knowledge, we are identifying immune modulators that help protect newborns from disease, and aid in their immune response to vaccines important for global health. This work is done in close collaboration with several large national (e.g. CHILD) and international research groups from Africa and Asia, to Europe, North America and Australia.

    Selected Publications

    Towards predicting protective vaccine responses in the very young. TR Kollmann and A Marchant. Trends in Immunology. 2016 Jun 22 [Epub ahead of print]. PMID: 27344245

    Harnessing the beneficial heterologous effects of vaccination. Goodridge HS, Ahmed SS, Curtis N, Kollmann TR, Levy O, Netea MG, Pollard AJ, van Crevel R, Wilson CB. Nat Rev Immunol. 16(6):392-400, 2016. PMID: 27157064

    Arrieta MC, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, Kuzeljevic B, Gold MJ, Britton HM, Lefebvre DL, Subbarao P, Mandhane P, Becker A, McNagny KM, Sears MR, Kollmann T; CHILD Study Investigators, Mohn WW, Turvey SE, Brett Finlay B.Early infancy microbial and metabolic alterations impact risk of childhood asthma. Sci Transl Med. 2015 Sep 30;7(307):307, PMID: 26424567

    Marchant EA, Kan B, Sharma AA, van Zanten A, Kollmann TR, Brant R, Lavoie PM. Attenuated innate immune defenses in very premature neonates during the neonatal period. Pediatr Res. 2015 Jul 17 [Epub ahead of print] PMID: 26186294

    Lissner MM, Thomas BJ, Wee K, Tong AJ, Smale ST, Kollmann TR. Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adult.  PLoS One. 2015 Jul 6;10(7):e0132061  PMID: 26147648

    Amenyogbe N., Levy O., T.R. Kollmann. Systems Vaccinology: a promise for the young and the poor. Phil. Trans. R. Soc. B. June 2015; 370(1671) PMID: 25964462

    Goenka A, Kollmann TR.  Development of immunity in early life.  J Infect. June 2015;71 Suppl 1: S112-20  PMID: 25934325

    D. M. MacGillivray and T.R. Kollmann. The role of environmental factors in modulating immune responses in early life. Front. Immunol. 5:434. 2014. PMID: 25309535

    P. Aaby, T.R. Kollmann, C. Stabell Benn. Non specific effects of neonatal and infant vaccination: public health, immunological, and conceptual challenges. Nature Immunology 15(10):895-899; 2014. PMID: 25232810

    K.K. Smolen, B. Cai, L. Gelinas, E.S. Fortuno, M. Larsen, D.P. Speert, M. Chamekh, P.J. Cooper, M. Esser, A. Marchant, T.R. Kollmann. Single cell analysis of innate cytokine responses to pattern recognition receptor stimulation in children across four continents. J. Immunol., 193(6):3003-12; 2014. PMID: 25135829

    Sherrid AM, Ruck CE, Sutherland D, Cai B, Kollmann TR. Lack of broad functional differences in immunity in fully vaccinated vs. unvaccinated children.Pediatr Res. 2016 Dec 26 PMID:28024144 

    Stiemsma LT, Arrieta MC, Dimitriu PA, Cheng J, Thorson L, Lefebvre DL, Azad MB, Subbarao P, Mandhane P, Becker A, Sears MR, Kollmann TR; Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators., Mohn WW, Finlay BB, Turvey SE. Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthmaClin Sci (Lond). 2016 Dec 1;130(23):2199-2207. PubMed PMID: 27634868.


    Yang H, Kozicky L, Saferali A, Fung SY, Afacan N, Cai B, Falsafi R, Gill E, Liu M, Kollmann TR. Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cellsBiomaterials. 2016 Dec;111:90-102. doi: 10.1016/j.biomaterials.2016.09.032. Epub 2016 Oct 3. PubMed PMID: 27728817.

    Grants
    “Systemic immunity: the missing link between gut microbiome and asthma”. CIHR Operating. Co-PI: Drs. William Mohn, Pedro Dimitriu & Tobias Kollmann.

    CIHR Operating Grant - Project: "Lower GBP1 expression reduces human host defense against Listeria monocytogenes." PI: Dr. Tobias Kollmann.

    Honours & Awards
    • Michael Smith Foundation for Health Research Career Investigator Award

    • Canadian Child Health Clinician Scientist Career Development Award

    • Burroughs Wellcome Career Award in the Biomedical Sciences

    • Pfizer Postdoctoral Fellowship in Infectious Diseases

    • Alpha Omega Alpha (National Honour Medical Society)

    Research Group Members
    • Dr. Rym Ben Othman Aniba – Post Doctoral Fellow

    • Sheka Aloyouni – PhD Graduate Student

    • Byron Brook – PhD Graduate Student

    • Danny Haberson – MSc Graduate Student

    • Dr. Bing Cai – Research Assistant

    • Daniel He – Research Assistant