• MacDonald, David


    Investigator, BC Children's Hospital
    Professor, Department of Oral Biological & Medical Science, Faculty of Dentistry, University of British Columbia

    Degrees / Designations

    BDS, BSc(Hons.), LLB(Hons.), MSc, DDS(Edin.), DDRRCR, FDSRCPS, FRCD(C)

    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Lab Phone
    Mailing Address

    University of British Columbia
    2199 Wesbrook Mall
    Vancouver, BC  V6T 1Z3

    Affiliate Websites
    Research Areas
    • Clinical and radiological presentations of the most frequent/important lesions affecting the face and jaws.
    • Development of systematic review that facilitates display of differences between global communities so as to enhance their management by clinicians practicing in these communities or attending to individuals from them.
    • Craniofacial anomalies.
    • The value and indications for cone-beam computed tomography use in the management of the child patient.
    • Calcified carotid artery atheromas.

    Clinical and X-ray presentations of the most frequent/important disease affecting the face and jaws, and how they differ between communities around the world. The purpose of this is to enhance their management by clinicians working in these communities or treating patients from them.

    Current Projects
    Selected Publications

    MacDonald-Jankowski DS. Fibro-osseous lesions of the face and jaws. Clinical Radiology 2004; 59: 11-25. This was the 3rd most frequently downloaded article for 2003/2004:and 8th for 2014. It has also been cited  241 times by Google and 110 times by Scopus.

    MacDonald DS. Maxillofacial fibro-osseous lesions. Clinical Radiology. 2015;70:25-36. Invited by the Editor-In-Chief to update 1. This is the first paper to cover the role of CBCT in the diagnosis and assessment of an important group of lesions. Already been cited 22 times by Google & 8 times by Scopus.

    Bryant R, MacDonald-Jankowski DS, Kim K. Does the type of implant prosthesis affect outcomes for the completely edentulous arch? International Journal of Oral Maxillofacial Implant 2007; 22 suppl: 117-139. It was the first systematic review to reveal the long-term outcomes of dental implants. It is still the most comprehensive systematic review on this topic. It has been cited 122 times by  Google and 67 times by Scopus.

    MacDonald DS et al. Diagnosis and management of calcified carotid artery atheroma: dental perspectives.  
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2012: 114: 533-547. This is the first report to place the importance of these lesions in a medical context. MacDonald initiated this and led a team of UBC/VGH medical and US dental radiologists.

    Palles C, ..., MacDonald D, ..., Tomlinson I, Jankowski J.Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.  Gastroenterology 2015;148: 367-378. The impact factor is 18.

    Bennett C*, Moayyedi P*, ..., MacDonald D, Barr H, Ferguson MK, Jankowski J  
    BOB CAT, a large-scale evidence review and consensus statements for management of Barrett's esophagus with no dysplasia, indefinite for, or low grade dysplasia, based on a Delphi Process. American Journal of Gastroenterology 2015;110: 662-682. The impact factor is 11. This is the largest systematic review ever published, addressing multiple research questions

    MacDonald DS. A systematic review of the literature of nevoid basal cell carcinoma syndrome affecting East Asians and North Europeans. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 2015. 120: 408-415. This revealed the significant differences existing between East Asians and Northern Europeans for this important syndrome.

    Baron M, Hudson M, Dagenais M, MacDonald D, ..., Gornitsky M. The Canadian Systemic Sclerosis Oral Health Study V: Relationship between disease characteristics and oral radiologic findings in systemic sclerosis Arthritis Care and Research (Hoboken) 2015 Sep 28. doi: 10.1002/acr.22739. The impact factor is 5. This Canadian Institutes of Health Research study is the largest study on Scleroderma published.

    MacDonald DS. Lesions of the jaws presenting as radiolucencies on cone-beam computed tomography. Clinical Radiology. 2016; 71: 972-985. Following on from Paper 2, focusing on the CBCT of the most frequent and/or important lesions of the jaws that present as radiolucencies.

    Gharahkjani P, ..., MacDonald D, ..., Jankowski J, Schumacher J. Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis. Lancet Oncol. 2016; 17:1363-1373 The impact factor is 28.

    Honours & Awards
    Research Group Members