Our research

The Center for International Child Health has developed Smart Discharges to help children stay healthy after they leave the hospital to return home following a severe infection. 

What is the problem?

      Children hospitalized for serious infections in Africa have a very high post-discharge mortality rate. This means that many children who seem healthy after an infection return to their homes and then get sick again and die. In places like Uganda, as many children die during the weeks after they are discharged from a hospital as die during hospitalization. The data shows this is about 5% in each case. Most of these deaths occur at home. This has been shown in several studies throughout Africa.

Serious infections can include pneumonia, diarrhea or malaria. The danger is when infections lead to sepsis. Sepsis is a life-threatening condition where the body's response to an infection damages its own tissues and organs. Instead of local inflammation resulting from a local infection, which would be the appropriate response, the body’s entire system goes into inflammation. Sepsis is the leading cause of death from infection around the world, despite advances in modern medicine like vaccines, antibiotics and acute care. Newborn babies, small children and the elderly are especially vulnerable.

Around the world, 6 to 8 million people die of sepsis every year. Children under five are especially vulnerable. We believe that many of these lives can be saved. One solution is identifying vulnerable children before they go home from the hospital so that we can make sure they have the tools to survive after they go home. This is the Smart Discharge model.

How do Smart Discharges work?

We use a simple mobile app powered by scientifically rigorous, data-driven prediction models to identify vulnerable children. We then give those children and their families more support when they are leaving the hospital at discharge. The discharge kit includes extra education, basic hygiene and health materials and referrals to their local health clinics so they can be checked up by local health care workers closer to home. It is an effective way to save lives.

We have been working in Uganda since 2011 to better understand how to identify children at risk and to design smart interventions. Our work has shown that five routinely collected clinical signs and symptoms (oxygen saturation, nutritional status, HIV status, prior admissions and coma score) at admission can accurately identify children who are at high risk of death after discharge. About 30% of children will be classified as high risk. Low-cost mobile phones are widely available. We add state-of-the-art mobile diagnostic tools to make it easy, quick, and accurate for health care workers in any setting to collect and analyse the data. These tools include a low-cost pulse oximeter and a respiratory rate app, both also developed by the Smart Discharges team. The app takes care of the complex and time-consuming math that translates signs and symptoms into risk predictions.
 

Where are Smart Discharges being used?

     

Smart Discharges are currently being implemented in four hospitals in southern Uganda, which together serve a catchment area of 31 districts: 

  • Mbarara Regional Referral Hospital
  • Holy Innocents Children’s Hospital
  • Jinja Regional Referral Hospital
  • Masaka Regional Referral Hospital
More sites are planned, with a goal of scaling nationally and expanding into other countries in East Africa within five years.

Why are Smart Discharges needed?

A good argument could be made that all children who are discharged are at risk and should receive good post-discharge care. However, in countries like Uganda, the resources are not always available to do this. This is why it is important to think about how to use limited resources smartly and precisely to help as many people as possible. We think about it as providing the right care to the right child at the right time.Smart Discharges help patients move from hospital to home and back again as needed with minimal changes to existing procedures. This is also important for parents of sick children. In countries like Uganda, visiting a clinic can be difficult and can mean long travel times on bad roads, so it is important to make sure the visit is really necessary.


Do Smart Discharges work?

Our preliminary results show:

  • a 3-fold increase in post-discharge follow-up, including visits to local health care clinics and workers
  • a 2-fold increase in re-admission, showing early identification and treatment of critically ill children
  • a 30% reduction in mortality

That means that children who receive a Smart Discharge are more likely to see a health care provider for at least one follow up visit, are more likely to be re-admitted to hospital if they get sick again, and are less likely to die in the weeks after being discharged from the hospital. We are currently working to validate the impact of Smart Discharges.

What is the evidence?

We studied 1,307 children from March 2012 to December 2013 to derive our prediction model, and then validated the model and tested the discharge kit with 216 children from December 2014 to April 2015. Our mobile app underwent extensive user testing to ensure it is easy to use and suited to local contexts.

Currently, we are enrolling children for a two-phase study to externally validate our models and the benefits of Smart Discharges. We are also working to develop specific models for babies and young infants from birth to 6 months of age. Newborn babies and young infants are vulnerable to different kinds of infections than older children and their bodies react differently to infection. We cannot just use our existing models for these newborns and young infants, so we are building new prediction models using the same processes. This study will take place until 2020 and will involve 8,700 children under the age of five.

We have published extensively on Smart Discharges. A list of publications is included below.

Publications

  1. Wiens MO, Kumbakumba E, Kissoon N, Ansermino JM, Ndamira A, Larson CP. Pediatric sepsis in the developing world: challenges in defining sepsis and issues in post-discharge mortality. Clinical epidemiology 2012; 4: 319-25.
  2. Wiens MO, Pawluk S, Kissoon N, et al. Pediatric post-discharge mortality in resource poor countries: a systematic review. PloS one 2013; 8(6): e66698.
  3. Wiens MO, Kumbakumba E, Larson CP, et al. Postdischarge mortality in children with acute infectious diseases: derivation of postdischarge mortality prediction models. BMJ open 2015; 5(11): e009449.
  4. Wiens MO, Gan H, Barigye C, et al. A cohort study of morbidity, mortality and health seeking behavior following rural health center visits by children under 12 in southwestern Uganda. PloS one 2015; 10(1): e0118055.
  5. Wiens MO, Kissoon N, Kumbakumba E, et al. Selecting candidate predictor variables for the modelling of post-discharge mortality from sepsis: a protocol development project. African health sciences 2016; 16(1): 162-9. 
  6. Lowlaavar N, Larson CP, Kumbakumba E, et al. Pediatric in-Hospital Death from Infectious Disease in Uganda: Derivation of Clinical Prediction Models. PloS one 2016; 11(3): e0150683.
  7. English LL, Dunsmuir D, Kumbakumba E, et al. The PAediatric Risk Assessment (PARA) Mobile App to Reduce Postdischarge Child Mortality: Design, Usability, and Feasibility for Health Care Workers in Uganda. JMIR mHealth and uHealth 2016; 4(1): e16.
  8. Wiens MO, Kumbakumba E, Larson C, et al. Scheduled follow-up referrals and simple prevention kits including counseling to improve post-discharge outcomes among children in Uganda: A proof of concept study. Global Health: Science and Practice 2016; 4(3): 422-34.
  9. English LL, Kumbakumba E, Larson C, et al. Pediatric out-of-hospital deaths following hospital discharge: A mixed-methods study. African Health Sciences 2016; 16(4): 883-91.
  10. Wiens MO, Larson CP, Kumbakumba E, et al. Application of Sepsis Definitions to Pediatric Patients Admitted With Suspected Infections in Uganda. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2016; 17(5): 400-5.

Our team

The Smart Discharges team includes experts with strengths and perspectives from different fields,countries, and contexts. The Centre for International Child Health at the BC Children’s Hospital is coordinating activities. Our team includes experts in child health, sepsis, neonatology, mobile health, epidemiology, technology, engineering, software development, business, and program management. 

Research team

  • Dr. Niranjan “Tex” Kissoon – Vice-President of Medical Affairs and Investigator, BC Children's; Professor, UBC Departments of Pediatrics and Surgery (Emergency Medicine)
  • Dr. Mark Ansermino – Director, Centre for International Child Health at BC Children’s; Co-Director, Digital Health Innovation Lab at BC Children’s; Professor, UBC Department of Anesthesia, Pharmacology and Therapeutics
  • Dr. Matthew Wiens – Postdoctoral Fellow, Centre for International Child Health
  • Dr. Jerome Kabakyenga – Director, Maternal, Newborn and Child Health Institute at Mbarara University of Science and Technology  
  • Dr. Elias Kumbakumba – Physician/Researcher, Mbarara Regional Referral Hospital; Associate Professor, Mbarara University of Science and Technology Faculty of Medicine
  • Dr. Celestine Barigye – Director, Mbarara Regional Referral Hospital
  • Dr. Stephen Businge – Director, Holy Innocents Children’s Hospital
  • Dr. Peter Moschovis – Physician/Investigatior, Massachusetts General Hospital   
  • Dr. Guy Dumont – Investigator, BC Children’s; Co-Director, Digital Health Innovation Lab at BC Children’s; Professor, UBC Department of Electrical and Computer Engineering
  • Dr. Charles Larson – Investigator, BC Children's Hospital; Clinical Professor, UBC Department of Pediatrics
  • Dr. Joel Singer – Professor, UBC School of Population and Public Health 

Software development team

  • Dustin Dunsmuir – Software Developer
  • Chris Peterson – Tech Development
  • Shaylene Beaudry – Junior Software Developer
  • Phaisal Lubega – Innovation Streams

Program management team

  • Bella Hwang – Program Manager, Centre for International Child Health
  • Michelle Langlois – Program Coordinator, Centre for International Child Health
  • Mellon Tayebwa – Project Coordinator

Support and thanks

The Smart Discharges team gratefully acknowledges our partners, the Ministry of Health in Uganda, and our current and previous donors, including Mining4Life, the Thrasher Research Fund, and Grand Challenges Canada for funding this project.



Contact

For more information, please contact Michelle Langlois or Matthew Wiens.

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