Michael Cuccione Childhood Cancer Research Program (MCCCRP)

Investigator Profiles

The research team is led by Dr. Kirk Schultz, director of the Michael Cuccione Childhood Cancer Research Program and co-lead of the Childhood Cancer & Blood Research Group at BC Children's Hospital. 

 

Dr. Kirk Schultz

Director, Michael Cuccione Childhood Cancer Research Program
Co-Lead and Investigator, Childhood Cancer & Blood Research Group, BC Children's Hospital
Professor, Division of Hematology and Oncology, Department of Pediatrics, University of British Columbia

Dr. Schultz’s research group focuses on controlling the immune forces unleashed by blood and marrow transplantation (BMT) to improve immune therapy for childhood leukemia. The goal of this work is to improve the ability to provide safe tissue transplants. As well, the team is focused on developing approaches to extend the ability to use blood-derived stem cells to regenerate damaged tissues and establish a healthy immune environment.   

For a list of Dr. Schultz's publications, click here.

   
   
 Childhood Cancer Researcher

Dr. Rebecca Deyell

Investigator, Michael Cuccione Childhood Cancer Research Program at BC Children's Hospital
Clinical Assistant Professor, Department of Pediatrics, Faculty of Medicine, University of British Columbia

Dr. Deyell is interested in developing early phase clinical trials in pediatric oncology to expedite the transition of new targeted drug therapies from the lab to the patient. She focuses on finding individualized approaches to targeted therapies for patients with incurable cancer.

For a list of Dr. Deyell's publications, click here.

   
   
 Childhood Cancer Researcher

Dr. Philipp Lange

Investigator, Michael Cuccione Childhood Cancer Research Program at BC Children's Hospital
Assistant Professor, Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia

Dr. Lange’s research focuses on proteins, the structural and functional building blocks of a cell. He combines proteomics and bioinformatics to monitor abnormal proteins in the body and detect how they are changed in cancer. His team is particularly interested in how the post-translational modification of proteins – the changes that occur to a protein as it becomes “mature” – affects cancer progression and secondary disease.

For a list of Dr. Lange's publications, click here.
   
   

Dr. Chinten James Lim

Investigator, Michael Cuccione Childhood Cancer Research Program at BC Children's Hospital
Assistant Professor, Department of Pediatrics, University of British Columbia

Dr. Lim and his research team are studying the interactions between leukemic cells and the bone marrow micro-environment, providing insight into how these interactions can alter the response of tumour cells to treatments such as chemotherapy. It is increasingly recognized that the tumour micro-environment is an important therapeutic target, specifically in the quest to minimize chances of relapse due to minimal residual disease (MRD).

For a list of Dr. Lim's publications, click here.

   
   

Dr. Christopher Maxwell

Investigator, Michael Cuccione Childhood Cancer Research Program at BC Children's Hospital
Co-Lead and Investigator, Childhood Cancer & Blood Research Group, BC Children's Hospital
Assistant Professor, Department of Pediatrics, University of British Columbia

Dr. Maxwell’s research team studies how brain stem cells respond to cues that encourage their growth and what goes awry when their division occurs without a key protein. By understanding how brain stem cells grow, Dr. Maxwell’s team hopes to discover how the process goes amiss and how to maintain healthy brain stem cells during cancer treatment.

For a list of Dr. Maxwell's publications, click here.

   
   

Childhood Cancer Researcher

Dr. Catherine Pallen

Investigator, Michael Cuccione Childhood Cancer Research Program at BC Children's Hospital
Professor, Division of Hematology and Oncology, Department of Pediatrics, University of British Columbia
Associate Member, Department of Pathology and Laboratory Medicine, University of British Columbia

Dr. Pallen’s lab investigates the molecular control of cell movement to understand how aggressive cancer cells are able to spread through the body. Her team is focused on a group of enzymes called protein tyrosine phosphatases (PTPs), which control cellular processes that go awry in cancer cells. The purpose of this research is to identify how these enzymes regulate cell movement and can be targeted for treatment to prevent migration to other parts of the body. Other research in Dr. Pallen’s lab focuses on how to repair damage caused to the brain by radiation treatment.

For a list of Dr. Pallen's publications, click here.

   
   
 Childhood Cancer Researcher

Dr. Rod Rassekh

Investigator, Michael Cuccione Childhood Cancer Research Program at BC Children's Hospital
Clinical Assistant Professor, Division of Oncology/ Hematology/ BMT, Department of Pediatrics, University of British Columbia

The focus of Dr. Rassekh’s research is to examine the long-term outcomes of children who received chemotherapy to treat cancer and understand the genetic reasons some children experience harmful side effects while others fare much better. Dr. Rassekh’s research team is working to find out how these side effects can be reduced through protective strategies or more targeted therapies.

For a list of Dr. Rassekh's publications, click here
   
   

Dr. Gregor Reid

Investigator, Michael Cuccione Childhood Cancer Research Program at BC Children's Hospital
Assistant Professor, Division of Hematology, Oncology and BMT, Department of Pediatrics, Faculty of Medicine, University of British Columbia

Dr. Reid explores the relationship between early-life infections and the risk of developing acute lymphoblastic leukemia (ALL), the most common childhood cancer. His team seeks to understand the influence of the immune system as cancer progresses and to use this knowledge to develop approaches to stimulate cancer-fighting immune activity.

For a list of Dr. Reid's publications, click here.

   
   

Childhood Cancer Researcher

Dr. Poul Sorensen

Investigator, Michael Cuccione Childhood Cancer Research Program at BC Children's Hospital
Professor, Department of Pathology, University of British Columbia

Cellular signal transduction pathways determine whether or not tumour cells divide and proliferate. Studying these pathways is central to understanding tumour cell biology. Dr. Sorensen’s research focuses on targeting these pathways as a treatment strategy, while minimizing effects on normal growth. Dr. Sorensen’s team investigates how mutations disrupt signal transduction in solid tumours and leukemias, with the goal of identifying new therapeutic targets.

For a list of Dr. Sorensen's publications, click here.