Overview

Kidney transplantation is a life-saving treatment for children with end-stage kidney failure. A major threat to success is rejection, where the body’s immune system attacks and destroys the transplanted kidney. If rejection isn't treated early, it results in permanent injury that can lead to loss of the transplant and a return to dialysis. Currently, tests that monitor kidney function will miss early or mild rejection. Instead, we screen with repeated kidney biopsies, which are risky and unpleasant.

This research program will use proven techniques to identify signs of kidney injury and rejection in the urine of children who have had a kidney transplant. It will focus on the first year after transplant, since this is the highest risk for rejection. We will look for metabolites and chemokines that we have tested before to identify when injury or rejection is present. Metabolites are small molecules produced by our cells as part of their function or as waste products. Chemokines are a different type of molecule that is produced by our immune system to signal inflammation. We already know some of the changes that occur with rejection. We now plan to validate that the same changes are present in other Canadian children with kidney transplants.

We will ask children with a new kidney transplant and their families to participate in this study. They will provide a urine sample for analysis whenever they have a kidney biopsy and also at regular intervals after transplant. We will verify the metabolite and chemokine levels that are linked to rejection, and could predict rejection in other children. Once it has been refined, we will determine whether it improves outcome by using it as a test for real-time monitoring and limit our use of regular kidney biopsies. We hope to demonstrate that this will improve the accuracy to detect rejection early, reduce the number of biopsies and improve the health and long-term kidney function of children with a transplant.

Publications

Risk factors associated with allograft failure in pediatric kidney transplant recipients with focal segmental glomerulosclerosis.
Pediatric transplantation
Koh LJ and Martz K and Blydt-Hansen TD and NAPRTCS Registry Investigators
DOI: 10.1111/petr.13469
PubMed: 31169337
06/2019

Acute Shoshin beriberi syndrome immediately post-kidney transplant with rapid recovery after thiamine administration.
Pediatric transplantation
Elias IM and Sinclair G and Blydt-Hansen TD
DOI: 10.1111/petr.13493
PubMed: 31124207
05/2019

Estimating glomerular filtration rate in youth with obesity and type 2 diabetes: the iCARE study equation.
Pediatric nephrology (Berlin, Germany)
Dart AB and McGavock J and Sharma A and Chateau D and Schwartz GJ and Blydt-Hansen T
DOI: 10.1007/s00467-019-04250-6
PubMed: 31049718
05/2019

Resolution of diagnosis and parental attitudes among parents of adolescent kidney recipients.
Pediatric transplantation
Leblond M and Achille M and Béliveau MJ and Clermont MJ and Blydt-Hansen T
DOI: 10.1111/petr.13472
PubMed: 31081267
05/2019

A Holistic Approach to Risk for Early Kidney Injury in Indigenous Youth With Type 2 Diabetes: A Proof of Concept Paper From the iCARE Cohort.
Canadian Journal of Kidney Health and Disease
Dart AB and Wicklow B and Blydt-Hansen TD and Sellers EAC and Malik S and Chateau D and Sharma A and McGavock JM
DOI: 10.1177/2054358119838836
PubMed: 31041107
04/2019

Non-invasive differentiation of non-rejection kidney injury from acute rejection in pediatric renal transplant recipients.
Pediatric transplantation
Archdekin B and Sharma A and Gibson IW and Rush D and Wishart DS and Blydt-Hansen TD
DOI: 10.1111/petr.13364
PubMed: 30719822
02/2019

Pediatric Outcomes in Transplant: PersOnaliSing Immunosuppression To ImproVe Efficacy (POSITIVE Study): The Collaboration and Design of a National Transplant Precision Medicine Program.
Transplantation direct
Papaz T and Allen U and Blydt-Hansen T and Birk PE and Min S and Hamiwka L and Phan V and Schechter T and Wall DA and Urschel S and Foster BJ and Mital S
DOI: 10.1097/TXD.0000000000000842
PubMed: 30584591
11/2018

Child and Parental Perspectives on Communication and Decision Making in Pediatric CKD: A Focus Group Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Gutman T and Hanson CS and Bernays S and Craig JC and Sinha A and Dart A and Eddy AA and Gipson DS and Bockenhauer D and Yap HK and Groothoff J and Zappitelli M and Webb NJA and Tong A
DOI: 10.1053/j.ajkd.2018.05.005
PubMed: 29980375
07/2018

Non-invasive staging of chronic kidney allograft damage using urine metabolomic profiling.
Pediatric transplantation
Landsberg A and Sharma A and Gibson IW and Rush D and Wishart DS and Blydt-Hansen TD
DOI: 10.1111/petr.13226
PubMed: 29855144
05/2018

The prognostic value of urinary chemokines at 6 months after pediatric kidney transplantation.
Pediatric transplantation
Mockler C and Sharma A and Gibson IW and Gao A and Wong A and Ho J and Blydt-Hansen TD
DOI: 10.1111/petr.13205
PubMed: 29733487
05/2018

Evolution of renal function and urinary biomarker indicators of inflammation on serial kidney biopsies in pediatric kidney transplant recipients with and without rejection.
Pediatric transplantation
Mincham CM and Gibson IW and Sharma A and Wiebe C and Mandal R and Rush D and Nickerson P and Ho J and Wishart DS and Blydt-Hansen TD
DOI: 10.1111/petr.13202
PubMed: 29696778
04/2018

Successful treatment of chronic norovirus gastroenteritis with nitazoxanide in a pediatric kidney transplant recipient.
Pediatric transplantation
Haubrich K and Gantt S and Blydt-Hansen T
DOI: 10.1111/petr.13186
PubMed: 29635723
04/2018

Estimating Time to ESRD in Children With CKD.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Furth SL and Pierce C and Hui WF and White CA and Wong CS and Schaefer F and Wühl E and Abraham AG and Warady BA and Chronic Kidney Disease in Children (CKiD) and Effect of Strict Blood Pressure Control and ACE Inhibition on the Progression of CRF in Pediatric Patients (ESCAPE) Study Investigators
DOI: 10.1053/j.ajkd.2017.12.011
PubMed: 29653769
04/2018

Screening for kidney disease in Indigenous Canadian children: The FINISHED screen, triage and treat program.
Paediatrics & Child Health
Dart A and Lavallee B and Chartrand C and McLeod L and Ferguson TW and Tangri N and Gordon A and Blydt-Hansen T and Rigatto C and Komenda P
DOI: 10.1093/pch/pxy013
PubMed: 30374222
04/2018

Determinants of Readiness for Adopting Healthy Lifestyle Behaviors Among Indigenous Adolescents with Type 2 Diabetes in Manitoba, Canada: A Cross-Sectional Study
Obesity
Jonathan McGavock and Anita Durksen and Brandy Wicklow and Sayma Malik and Elizabeth AC Sellers and Tom Blydt-Hansen and Dan Chateau and Allison Dart
DOI: 10.1002/oby.22148
03/2018

Practice Patterns in the Treatment and Monitoring of Acute T Cell–Mediated Kidney Graft Rejection in Canada
Canadian Journal of Kidney Health and Disease
Julie Leblanc and Peter Subrt and Michèle Paré and David Hartell and Lynne Sénécal and Tom Blydt-Hansen and Héloïse Cardinal
DOI: 10.1177/2054358117753616
01/2018

Progression and Regression of Albuminuria in Youth with Type 2 Diabetes
Canadian Journal of Diabetes
Farrah Jabar and Brandy Wicklow and Jonathan McGavock and Elizabeth Sellers and Tom Blydt-Hansen and Kristine Kroeker and Dan Chateau and Allison Dart
DOI: 10.1016/j.jcjd.2017.08.025
10/2017

Urinary Metabolomics for Noninvasive Detection of Antibody-Mediated Rejection in Children After Kidney Transplantation
Transplantation
Tom D. Blydt-Hansen and Atul Sharma and Ian W. Gibson and David S. Wishart and Rupasri Mandal and Julie Ho and Peter Nickerson and David Rush
DOI: 10.1097/tp.0000000000001662
10/2017

Vitamin D Status in Indigenous Youth with Type 2 Diabetes
Canadian Journal of Diabetes
Melissa Gabbs and Allison Dart and Farrah Jabar and Kristine Kroeker and Tom Blydt-Hansen and Jon Mcgavock and Brandy Wicklow
DOI: 10.1016/j.jcjd.2017.08.207
10/2017

Class II Eplet Mismatch Modulates Tacrolimus Trough Levels Required to Prevent Donor-Specific Antibody Development
Journal of the American Society of Nephrology
Chris Wiebe and David N. Rush and Thomas E. Nevins and Patricia E. Birk and Tom Blydt-Hansen and Ian W. Gibson and Aviva Goldberg and Julie Ho and Martin Karpinski and Denise Pochinco and Atul Sharma and Leroy Storsley and Arthur J. Matas and Peter W. Nickerson
DOI: 10.1681/asn.2017030287
07/2017

Albuminuria, Proteinuria, and Renal Disease Progression in Children with CKD
Clinical Journal of the American Society of Nephrology
Dana Y. Fuhrman and Michael F. Schneider and Katherine M. Dell and Tom D. Blydt-Hansen and Robert Mak and Jeffrey M. Saland and Susan L. Furth and Bradley A. Warady and Marva M. Moxey-Mims and George J. Schwartz
DOI: 10.2215/cjn.11971116
05/2017

Adverse symptoms of immunosuppressants: A survey of Canadian transplant clinicians
Clinical Transplantation
Jennifer J. Harrison and Holly Mansell and Tom Blydt-Hansen
DOI: 10.1111/ctr.12940
03/2017

Evaluation of C1q Status and Titer of De Novo Donor-Specific Antibodies as Predictors of Allograft Survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
DOI: 10.1111/ajt.14015
PubMed: 27539748
03/2017

Design and Methods of the Pan-Canadian Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Nephrotoxicity Study: A Prospective Observational Cohort Study.
Canadian journal of kidney health and disease
DOI: 10.1177/2054358117690338
PubMed: 28270931
2017

P044 C1q status and titer of de novo donor specific antibodies are not predictors of allograft survival
Human Immunology
Chris Wiebe and Alison Gareau and Denise Pochinco and Ian Gibson and Julie Ho and Patricia Birk and Tom Blydt-Hansen and Martin Karpinski and Aviva Goldberg and Leroy Storsley and David Rush and Peter Nickerson
DOI: 10.1016/j.humimm.2016.07.109
09/2016

Canadian Forum on Combined Organ Transplantation
Transplantation
Marcelo Cantarovich and Tom D. Blydt-Hansen and John Gill and Kathryn Tinckam and Jeffrey Schiff and Ian Alwayn and Vince Bain and Anne I. Dipchand and Debra Isaac and S. Joseph Kim and Dale Lien and Jeffrey Zaltzman and Kimberly Young and Peter Nickerson
DOI: 10.1097/tp.0000000000000963
06/2016

Genetic loci associated with renal function measures and chronic kidney disease in children: the Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
DOI: 10.1093/ndt/gfv342
PubMed: 26420894
02/2016

Kidney Disease Progression in Autosomal Recessive Polycystic Kidney Disease.
The Journal of pediatrics
Dell KM and Matheson M and Hartung EA and Warady BA and Furth SL and Chronic Kidney Disease in Children (CKiD) Study
DOI: 10.1016/j.jpeds.2015.12.079
PubMed: 26831744
01/2016

Rates and Determinants of Progression to Graft Failure in Kidney Allograft Recipients WithDe NovoDonor-Specific Antibody
American Journal of Transplantation
C. Wiebe and I. W. Gibson and T. D. Blydt-Hansen and D. Pochinco and P. E. Birk and J. Ho and M. Karpinski and A. Goldberg and L. Storsley and D. N. Rush and P. W. Nickerson
DOI: 10.1111/ajt.13347
06/2015

Elevated Urinary CXCL10-to-Creatinine Ratio Is Associated With Subclinical and Clinical Rejection in Pediatric Renal Transplantation
Transplantation
Tom D. Blydt-Hansen and Ian W. Gibson and Ang Gao and Brenden Dufault and Julie Ho
DOI: 10.1097/tp.0000000000000419
04/2015

Progression of Pediatric CKD of Nonglomerular Origin in the CKiD Cohort
Clinical Journal of the American Society of Nephrology
S. A. Fathallah-Shaykh and J. T. Flynn and C. B. Pierce and A. G. Abraham and T. D. Blydt-Hansen and S. F. Massengill and M. M. Moxey-Mims and B. A. Warady and S. L. Furth and C. S. Wong
DOI: 10.2215/cjn.07480714
01/2015

Beating Diabetes Together: A Mixed-Methods Analysis of a Feasibility Study of Intensive Lifestyle Intervention for Youth with Type 2 Diabetes
Canadian Journal of Diabetes
Elizabeth Huynh and Danielle Rand and Caitlin McNeill and Sarah Brown and Martin Senechal and Brandy Wicklow and Allison Dart and Elizabeth Sellers and Heather Dean and Tom Blydt-Hansen and Jonathan McGavock
DOI: 10.1016/j.jcjd.2015.09.093
2015

Description of a Novel Collaborative Joint Pediatric Renal and Type 2 Diabetes Clinic
Canadian Journal of Diabetes
Megan Bale and Tom Blydt-Hansen and Julie Halipchuk and Allison Dart and Brandy Wicklow
DOI: 10.1016/j.jcjd.2014.07.093
10/2014

The Improving Renal Complications in Adolescents With Type 2 Diabetes Through the REsearch (iCARE) Cohort Study: Rationale and Protocol
Canadian Journal of Diabetes
Allison B. Dart and Brandy A. Wicklow and Elizabeth A. Sellers and Heather J. Dean and Sayma Malik and John Walker and Dan Chateau and Tom D. Blydt-Hansen and Jonathan M. McGavock
DOI: 10.1016/j.jcjd.2014.07.224
10/2014

How should we identify early chronic kidney disease risk in non-kidney transplant recipients?
Pediatric Transplantation
Tom D. Blydt-Hansen and Allison B. Dart
DOI: 10.1111/petr.12356
09/2014

Antibody-Mediated Rejection
Transplantation
Manuel Arias and David N. Rush and Chris Wiebe and Ian W. Gibson and Tom D. Blydt-Hansen and Peter W. Nickerson and Joana Sellarés and Marcos López-Hoyos and David San Segundo and María G. Crespo-Leiro and Raquel Marzoa-Rivas and Eduardo Barge-Caballero and María J. Paniagua-Martín and Antonio Román and Daniel Serón and Georg Böhmig and Elisabeth Schwaiger
DOI: 10.1097/tp.0000000000000218
08/2014

Guidance on the use of increased infectious risk donors for organ transplantation.
Transplantation
DOI: 10.1097/tp.0000000000000251
PubMed: 25243510
08/2014

Meeting Report: Consensus Recommendations for a Research Agenda in Exercise in Solid Organ Transplantation
American Journal of Transplantation
S. Mathur and T. Janaudis-Ferreira and L. Wickerson and L. G. Singer and J. Patcai and D. Rozenberg and T. Blydt-Hansen and E. L. Hartmann and M. Haykowsky and D. Helm and K. High and N. Howes and B. M. Kamath and L. Lands and S. Marzolini and C. Sonnenday
DOI: 10.1111/ajt.12874
08/2014

Urinary Metabolomics for Noninvasive Detection of Borderline and Acute T Cell-Mediated Rejection in Children After Kidney Transplantation
American Journal of Transplantation
T. D. Blydt-Hansen and A. Sharma and I. W. Gibson and R. Mandal and D. S. Wishart
DOI: 10.1111/ajt.12837
08/2014

Evidence for the use of glomerulomegaly as a surrogate marker of glomerular damage and for alpha-linolenic acid-rich oils in the treatment of early obesity-related glomerulopathy in a diet-induced rodent model of obesity
Applied Physiology, Nutrition, and Metabolism
Stephanie P.B. Caligiuri and Tom Blydt-Hansen and Karin Love and Mélanie Grégoire and Carla G. Taylor and Peter Zahradka and Harold M. Aukema
DOI: 10.1139/apnm-2013-0476
08/2014

Canadian Society of Nephrology Commentary on the 2012 KDIGO Clinical Practice Guideline for the Management of Blood Pressure in CKD
American Journal of Kidney Diseases
Marcel Ruzicka and Robert R. Quinn and Phil McFarlane and Brenda Hemmelgarn and G.V. Ramesh Prasad and Janusz Feber and Gihad Nesrallah and Martin MacKinnon and Navdeep Tangri and Brendan McCormick and Sheldon Tobe and Tom D. Blydt-Hansen and Swapnil Hiremath
DOI: 10.1053/j.ajkd.2014.03.003
06/2014

Skeletal findings in the first 12 months following initiation of glucocorticoid therapy for pediatric nephrotic syndrome.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
DOI: 10.1007/s00198-013-2466-7
PubMed: 23948876
02/2014

Effect of sirolimus on malignancy and survival after kidney transplantation: systematic review and meta-analysis of individual patient data.
BMJ (Clinical research ed.)
DOI: 10.1136/bmj.g6679
PubMed: 25422259
2014

Medication Treatment Complexity and Adherence in Children with CKD
Clinical Journal of the American Society of Nephrology
T. D. Blydt-Hansen and C. B. Pierce and Y. Cai and D. Samsonov and S. Massengill and M. Moxey-Mims and B. A. Warady and S. L. Furth
DOI: 10.2215/cjn.05750513
11/2013

Class II HLA Epitope Matching-A Strategy to MinimizeDe NovoDonor-Specific Antibody Development and Improve Outcomes
American Journal of Transplantation
C. Wiebe and D. Pochinco and T. D. Blydt-Hansen and J. Ho and P. E. Birk and M. Karpinski and A. Goldberg and L. J. Storsley and I. W. Gibson and D. N. Rush and P. W. Nickerson
DOI: 10.1111/ajt.12478
10/2013

Substantial practice variation exists in the management of childhood nephrotic syndrome
Pediatric Nephrology
Susan Samuel and Catherine J. Morgan and Martin Bitzan and Cherry Mammen and Allison B. Dart and Braden J. Manns and R. Todd Alexander and Robin L. Erickson and Silviu Grisaru and Andrew W. Wade and Tom Blydt-Hansen and Janusz Feber and Steven Arora and Christoph Licht and Michael Zappitelli
DOI: 10.1007/s00467-013-2546-0
08/2013

Dietary Linoleic Acid and  -Linolenic Acid Differentially Affect Renal Oxylipins and Phospholipid Fatty Acids in Diet-Induced Obese Rats
Journal of Nutrition
S. P. B. Caligiuri and K. Love and T. Winter and J. Gauthier and C. G. Taylor and T. Blydt-Hansen and P. Zahradka and H. M. Aukema
DOI: 10.3945/jn.113.177360
07/2013

Assessment of Identity and Quality of Life in Diabetic and Renal Transplant Adolescents in Comparison to Healthy Adolescents
Journal of Clinical Psychology in Medical Settings
Tziona Lugasi and Marie Achille and Tom Blydt-Hansen and Marie-José Clermont and Louis Geoffroy and Laurent Legault and Véronique Phan and Lorraine E. Bell
DOI: 10.1007/s10880-012-9344-x
05/2013

The impact of short stature on health-related quality of life in children with chronic kidney disease.
The Journal of pediatrics
Al-Uzri A and Matheson M and Gipson DS and Mendley SR and Hooper SR and Yadin O and Rozansky DJ and Moxey-Mims M and Furth SL and Warady BA and Gerson AC and Chronic Kidney Disease in Children Study Group
DOI: 10.1016/j.jpeds.2013.03.016
PubMed: 23628375
04/2013

The development of bone mineral lateralization in the arms.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
DOI: 10.1007/s00198-012-2054-2
PubMed: 22744715
03/2013

Pediatric kidney transplant practice patterns and outcome benchmarks, 1987-2010: A report of the North American Pediatric Renal Trials and Collaborative Studies
Pediatric Transplantation
Jodi M. Smith and Karen Martz and Tom D. Blydt-Hansen
DOI: 10.1111/petr.12034
01/2013

Association of Income Level With Kidney Disease Severity and Progression Among Children and Adolescents With CKD: A Report From the Chronic Kidney Disease in Children (CKiD) Study
American Journal of Kidney Diseases
Guillermo Hidalgo and Derek K. Ng and Marva Moxey-Mims and Maria Lourdes Minnick and Tom Blydt-Hansen and Bradley A. Warady and Susan L. Furth
DOI: 10.1053/j.ajkd.2013.06.013
2013

Evolution and Clinical Pathologic Correlations of De Novo Donor-Specific HLA Antibody Post Kidney Transplant
American Journal of Transplantation
C. Wiebe and I. W. Gibson and T. D. Blydt-Hansen and M. Karpinski and J. Ho and L. J. Storsley and A. Goldberg and P. E. Birk and D. N. Rush and P. W. Nickerson
DOI: 10.1111/j.1600-6143.2012.04013.x
03/2012

Skeletal findings in children recently initiating glucocorticoids for the treatment of nephrotic syndrome.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
DOI: 10.1007/s00198-011-1621-2
PubMed: 21494860
02/2012

Incident vertebral fractures among children with rheumatic disorders 12 months after glucocorticoid initiation: a national observational study.
Arthritis care & research
DOI: 10.1002/acr.20589
PubMed: 22213727
01/2012

Pretransplant serologic testing to identify the risk of polyoma BK viremia in pediatric kidney transplant recipients
Pediatric Transplantation
Abdalla M. Ali and Ian W. Gibson and Patricia Birk and Tom D. Blydt-Hansen
DOI: 10.1111/j.1399-3046.2011.01583.x
11/2011

Reliability of resting blood pressure measurement and classification using an oscillometric device in children with chronic kidney disease.
The Journal of pediatrics
Flynn JT and Pierce CB and Miller ER and Charleston J and Samuels JA and Kupferman J and Furth SL and Warady BA and Chronic Kidney Disease in Children Study Group
DOI: 10.1016/j.jpeds.2011.08.071
PubMed: 22048052
11/2011

Enhanced resolution of interstitial fibrosis in pediatric renal allograft biopsies using image analysis of trichrome stain
Pediatric Transplantation
Patricia E. Birk and John S. Gill and Tom D. Blydt-Hansen and Ian W. Gibson
DOI: 10.1111/j.1399-3046.2010.01376.x
10/2010

Policy Statement of Canadian Society of Transplantation and Canadian Society of Nephrology on Organ Trafficking and Transplant Tourism
Transplantation
John S. Gill and Aviva Goldberg and G. V. Ramesh Prasad and Marie-Chantal Fortin and Tom-Blydt Hansen and Adeera Levin and Jagbir Gill and Marcello Tonelli and Lee Anne Tibbles and Greg Knoll and Edward H. Cole and Timothy Caulfield
DOI: 10.1097/tp.0b013e3181efd030
10/2010

Histological progression of chronic renal allograft injury comparing sirolimus and mycophenolate mofetil-based protocols. A single-center, prospective, randomized, controlled study
Pediatric Transplantation
Tom D. Blydt-Hansen and Ian W. Gibson and Patricia E. Birk
DOI: 10.1111/j.1399-3046.2010.01374.x
09/2010

Transplantation outcomes in primary hyperoxaluria.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Bergstralh EJ and Monico CG and Lieske JC and Herges RM and Langman CB and Hoppe B and Milliner DS and IPHR Investigators
DOI: 10.1111/j.1600-6143.2010.03271.x
PubMed: 20849551
09/2010

Canadian Society of Transplantation and Canadian Society of Nephrology Commentary on the 2009 KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients
American Journal of Kidney Diseases
Greg A. Knoll and Tom D. Blydt-Hansen and Patricia Campbell and Marcelo Cantarovich and Edward Cole and Todd Fairhead and John S. Gill and Sita Gourishankar and Diane Hebert and Anthony Hodsman and Andrew A. House and Atul Humar and Martin Karpinski and S. Joseph Kim and Rahul Mainra and G.V. Ramesh Prasad
DOI: 10.1053/j.ajkd.2010.05.004
08/2010

Patterns of Chronic Injury in Pediatric Renal Allografts
Transplantation
Allison B. Dart and Albrecht Schall and Ian W. Gibson and Tom D. Blydt-Hansen and Patricia E. Birk
DOI: 10.1097/tp.0b013e3181bc5e49
02/2010

The Use of Immunoglobulin Therapy for Patients Undergoing Solid Organ Transplantation: An Evidence-Based Practice Guideline
Transfusion Medicine Reviews
Nadine Shehata and Valerie A. Palda and Ralph M. Meyer and Tom D. Blydt-Hansen and Patricia Campbell and Carl Cardella and Steven Martin and Peter Nickerson and Kevork Peltekian and Heather Ross and Tom K. Waddell and Lori West and David Anderson and John Freedman and Heather Hume
DOI: 10.1016/j.tmrv.2009.09.010
01/2010

Masked Hypertension Associates with Left Ventricular Hypertrophy in Children with CKD
Journal of the American Society of Nephrology
M. Mitsnefes and J. Flynn and S. Cohn and J. Samuels and T. Blydt-Hansen and J. Saland and T. Kimball and S. Furth and B. Warady and for the CKiD Study Group
DOI: 10.1681/asn.2009060609
11/2009

Advanced vertebral fracture among newly diagnosed children with acute lymphoblastic leukemia: results of the Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) research program.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
DOI: 10.1359/jbmr.090202
PubMed: 19210218
07/2009

Macroalbuminuria and Renal Pathology in First Nation Youth With Type 2 Diabetes
Diabetes Care
E. A.C. Sellers and T. D. Blydt-Hansen and H. J. Dean and I. W. Gibson and P. E. Birk and M. Ogborn
DOI: 10.2337/dc08-1828
02/2009

The concurrent presentation of minimal change nephrotic syndrome and aplastic anemia
Pediatric Nephrology
Elissa Michele Abrams and Ian W. Gibson and Tom David Blydt-Hansen
DOI: 10.1007/s00467-008-0994-8
09/2008

Changes in height, BMI and bone density in children with nephrotic syndrome during six months prospective follow-up
American Society of Nephrology
2008

Low incidence of adverse events in outpatient pediatric renal allograft biopsies
Pediatric Transplantation
Patricia E. Birk and Tom D. Blydt-Hansen and Allison B. Dart and Lisa M. Kaita and Cynthia Proulx and Gerald Taylor
DOI: 10.1111/j.1399-3046.2006.00659.x
03/2007

Pediatric ESRD in Canada: A review of the last quarter century
CIHI Annual Report
2007

Biopsy-proven acute tubular necrosis in a child attributed to vancomycin intoxication
Pediatric Nephrology
Brandy Alexandra Wicklow and Malcolm Robert Ogborn and Ian William Gibson and Tom David Blydt-Hansen
DOI: 10.1007/s00467-006-0152-0
05/2006

Canadian Society of Transplantation consensus guidelines on eligibility for kidney transplantation.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
DOI: 10.1503/cmaj.051291
PubMed: 16275969
11/2005

Surveillance biopsies are superior to functional studies for the diagnosis of acute and chronic renal allograft pathology in children
Pediatric Transplantation
Patricia E. Birk and Karen M. Stannard and Helen B. Konrad and Tom D. Blydt-Hansen and Malcolm R. Ogborn and Mary S. Cheang and John G. Gartner and Ian W. Gibson
DOI: 10.1046/j.1397-3142.2003.00122.x
02/2004

Gene Transfer-Induced Local Heme Oxygenase-1 Overexpression Protects Rat Kidney Transplants From Ischemia/Reperfusion Injury
Journal of the American Society of Nephrology
T. D. Blydt-Hansen
DOI: 10.1097/01.asn.0000050760.87113.25
03/2003

Children are not small adults.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
PubMed: 12566324
02/2003

PHEX expression in parathyroid gland and parathyroid hormone dysregulation in X-linked hypophosphatemia
Pediatric Nephrology
Tom D. Blydt-Hansen and Harriet S. Tenenhouse and Paul Goodyer
DOI: 10.1007/s004670050669
08/1999

RECOVERY OF RESPIRATORY SYNCYTIAL VIRUS FROM STETHOSCOPES BY CONVENTIONAL VIRAL CULTURE AND POLYMERASE CHAIN REACTION
The Pediatric Infectious Disease Journal
Tom Blydt-Hansen and Kanta Subbarao and Patrick Quennec and Jane McDonald
DOI: 10.1097/00006454-199902000-00017
02/1999

Research

The CNTRP (Canadian National Transplant Research Program)
is a CIHR co-funded large network of researchers who are collectively undertaking 6 unique research programs that are supported by 3 cores. This includes a pediatric solid organ transplant research program that will focus on age and developmental changes in the immune system, drug pharmacokinetics, viral infection susceptibility and systems-related issues affecting adherence across the spectrum of mid and late-adolescence.

The PROBE Multicenter Cohort study
(Pediatric Renal transplant Optimization using BiomarkErs) is a CHIR funded program to identify urine biomarkers of kidney allograft injury such as acute rejection, in children after kidney transplantation. It follows on an initial cohort study that has identified urinary chemokines and metabolite profiles that accurately detect acute rejecton. The current study will validate these findings in a multi-center cohort, establish the time-course for appearance and disappearance of "risk" signals in the first year after transplant, and deterimine the whether these events which are not otherwise detectable are associated with worse long-term outcome as measured by histology, kidney function and development of de novo donor-specific antibodies.

Grants

Canadian Institutes of Health Research (CIHR) “Applying Biomarkers to Long-term Effects in Child and Adolescent Cancer Treatment (ABLE Team).” Oct 2011-Sep 2016. PI: Schultz, Kirk Raymond, Tom Blydt-Hansen (collaborator), L.R. Brandao, R. Broady, B.C. Carleton, G. Cuvelier, M.R. Hayden, A.Y.Y. Lee, M.N.Pinsk, C.J.D. Ross, M. Spavor.

Astellas Pharma Canada, Inc. “PROBE-Adherence: Therapeutic drug exposure and outcome in pediatric kidney transplant recipients converting from twice-daily tacrolimus to daily extended-release tacrolimus.” Apr 2014- Sept 2018. PI: Tom Blydt-Hansen, Beth Foster, Ian Gibson, Julie Ho, Peter Nickerson, Atul Sharma, David Wishart.

Canadian Diabetes Association “Improving cardiovascular risk in adolescents with diabetes through research (iCARE).” Jan 2011-Dec 2014. PI: Allison Dart, Tom Blydt-Hansen (co-investigator), J. McGavock, E. Sellers, H. Dean.

Children's Hospital Foundation of Manitoba. "Pediatric Kidney Health and Transplant Education Resource: Pre-Transplant". December 2014. April 1 2015 - March 30 2016. PI: Julie Strong, Tom Blydt-Hansen.

Canadian Institutes of Health Research (CIHR) “Non-Invasive monitoring of pediatric kidney allograft injury to improve diagnosis and patient outcomes” Oct 2012- Sep 2017. PI: Tom Blydt-Hansen, Julie Ho, Peter Nickerson, David Wishart, Ian Gibson.

Canadian Institutes of Health Research (CIHR) “Canadian National Transplant Research Program (CNTRP).” Apr 2013- Mar 2018. PI: West L. Caulfield T, Hebert MJ, Humar A, Knoll G, Levings M, Mital S, Roy DC, Schultz K, Shapiro J, Tom Blydt-Hansen.

Astellas Canada "PROBE Adherence: Therapeutic drug exposure and outcome in pediatric kidney transplant recipients converting from twice-daily tacrolimus to daily extended-release tacrolimus". June 2014 - May 2018. PI: Tom Blydt-Hansen.

Research Group Members

Azim Ahmed, Undergraduate Student
Jantzen Fan, Medical Flex Student
Alexandra Franiek, Medical Student
Bita Geramizadeh, Research Coordinator
Tara Gholamian, Undergraduate Student
Or Golan, Graduate Student
Mike Guron, Research Staff
Adina Landsberg, Research Student
Sam Lang, Medical Student
Samantha Lang, Research Student
Oscar Lau, Research Assistant, Research Assistant
Samantha Lui, FLeX Medical Student
Daniel Mun, Research Volunteer
Tyki Sueyoshi, Research Assistant
Candice Wiedman, Research Assistant