- Overview
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Kidney transplantation is a life-saving treatment for children with end-stage kidney failure. A major threat to success is rejection, where the body’s immune system attacks and destroys the transplanted kidney. If rejection isn't treated early, it results in permanent injury that can lead to loss of the transplant and a return to dialysis. Currently, tests that monitor kidney function will miss early or mild rejection. Instead, we screen with repeated kidney biopsies, which are risky and unpleasant.
This research program will use proven techniques to identify signs of kidney injury and rejection in the urine of children who have had a kidney transplant. It will focus on the first year after transplant, since this is the highest risk for rejection. We will look for metabolites and chemokines that we have tested before to identify when injury or rejection is present. Metabolites are small molecules produced by our cells as part of their function or as waste products. Chemokines are a different type of molecule that is produced by our immune system to signal inflammation. We already know some of the changes that occur with rejection. We now plan to validate that the same changes are present in other Canadian children with kidney transplants.
We will ask children with a new kidney transplant and their families to participate in this study. They will provide a urine sample for analysis whenever they have a kidney biopsy and also at regular intervals after transplant. We will verify the metabolite and chemokine levels that are linked to rejection, and could predict rejection in other children. Once it has been refined, we will determine whether it improves outcome by using it as a test for real-time monitoring and limit our use of regular kidney biopsies. We hope to demonstrate that this will improve the accuracy to detect rejection early, reduce the number of biopsies and improve the health and long-term kidney function of children with a transplant.
- Publications
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Sex differences in kidney metabolism may reflect sex-dependent outcomes in human diabetic kidney disease
Science Translational Medicine
DOI: 10.1126/scitranslmed.abm2090
2024Vertebral Body Reshaping after Fractures: An Important Index of Recovery in Glucocorticoid-Treated Children
Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/clinem/dgad611
2024Metabolomic identification of predictive and early biomarkers of cisplatin-induced acute kidney injury in adult head and neck cancer patients
British Journal of Clinical Pharmacology
DOI: 10.1111/bcp.15666
2024Exploring the ability of ChatGPT to create quality patient education resources about kidney transplant
Patient Education and Counseling
DOI: 10.1016/j.pec.2024.108400
2024Detection of Subclinical Rejection in Pediatric Kidney Transplantation: Current and Future Practices
Pediatric Transplantation
DOI: 10.1111/petr.14836
2024COVID-19 disease among children and young adults enrolled in the North American Pediatric Renal Trials and Collaborative Studies registry
Pediatric Nephrology
DOI: 10.1007/s00467-023-06241-0
2024Immune phenotyping in a pediatric multicenter transplant study: Suitability of a preformulated dry-antibody panel system
Human Immunology
DOI: 10.1016/j.humimm.2024.110837
2024Risk Factors of Post-Traumatic Stress in Pediatric Solid Organ Transplant Recipients
Pediatric transplantation
DOI: 10.1111/petr.14854
2024Optimizing the approach to monitoring allograft inflammation using serial urinary CXCL10/creatinine testing in pediatric kidney transplant recipients
Pediatric Transplantation
DOI: 10.1111/petr.14718
2024Developing Guidance for Donor Intervention Randomized Controlled Trials: Initial Discussions From the Canada-United Kingdom 2022 Workshop
Transplantation
DOI: 10.1097/TP.0000000000004983
2024Let's get physical: Aerobic capacity, muscle strength, and muscle endurance after pediatric heart transplantation
Pediatric Transplantation
DOI: 10.1111/petr.14731
2024An 8-Week Virtual Exercise Training Program for Pediatric Solid Organ Transplant Recipients
Pediatric Exercise Science
DOI: 10.1123/pes.2023-0066
2024Adrenal insufficiency in pediatric kidney transplantation recipients
Pediatric Transplantation
DOI: 10.1111/petr.14768
2024Follow-up biopsies identify high rates of persistent rejection in pediatric kidney transplant recipients after treatment of T cell-mediated rejection
Pediatric Transplantation
DOI: 10.1111/petr.14617
2024Urinary TIMP-2*IGFBP-7 to diagnose acute kidney injury in children receiving cisplatin
Pediatric Nephrology
DOI: 10.1007/s00467-023-06007-8
2024Tubular Injury Biomarkers to Predict CKD and Hypertension at 3 Months Post-Cisplatin in Children
Kidney360
DOI: 10.34067/KID.0000000000000448
2024Exploring the Ethical Considerations of Direct Contact in Pediatric Organ Transplantation: A Qualitative Study
AJOB Empirical Bioethics
Jordan Joseph Wadden and Jordan Hermiston and Tom D. Blydt-Hansen and Ranjeet Dhaliwal and Shelby Gielen and Alice Virani
DOI: 10.1080/23294515.2022.2160513
07/2023Noninvasive testing for mycophenolate exposure in children with renal transplant using urinary metabolomics
Pediatric Transplantation
Khalid Taha and Atul Sharma and Kristine Kroeker and Colin Ross and Bruce Carleton and David Wishart and Mara Medeiros and Tom D. Blydt-Hansen
DOI: 10.1111/petr.14460
05/2023Differences in medication adherence by sex and organ type among adolescent and young adult solid organ transplant recipients
Pediatric Transplantation
Yulia Vaisbourd and Mourad Dahhou and Xun Zhang and Ruth Sapir-Pichhadze and Heloise Cardinal and Olwyn Johnston and Tom D. Blydt-Hansen and Lee Anne Tibbles and Lorraine Hamiwka and Simon Urschel and Patricia Birk and Janice Bissonnette and Mina Matsuda-Abedini and Jennifer Harrison BScPhm and Jeffrey Schiff and Veronique Phan and Sabina De Geest and Upton Allen and Yaron Avitzur and Seema Mital and Bethany J. Foster
DOI: 10.1111/petr.14446
03/2023Acute kidney injury during cisplatin therapy and associations with kidney outcomes 2 to 6 months post-cisplatin in children: a multi-centre, prospective observational study
Pediatric Nephrology
DOI: 10.1007/s00467-022-05745-5
2023Blood Pressure Classification Status in Children With CKD Following Adoption of the 2017 American Academy of Pediatrics Guideline
American Journal of Kidney Diseases
DOI: 10.1053/j.ajkd.2022.10.009
2023Vitamin D Toxicity from an Unusual and Unexpected Source: A Report of 2 Cases
Hormone Research in Paediatrics
DOI: 10.1159/000526755
2023Parent and healthcare provider views of live varicella vaccination of pediatric solid organ transplant recipients
Pediatric Transplantation
DOI: 10.1111/petr.14609
2023International Pediatric Transplant Association (IPTA) position statement supporting prioritizing pediatric recipients for deceased donor organ allocation
Pediatric Transplantation
Freeman, M.A. and Botha, J. and Brewer, E. and Damian, M. and Ettenger, R. and Gambetta, K. and Lefkowitz, D.S. and Ross, L. and Superina, R. and McCulloch, M. and Blydt-Hansen, T.
DOI: 10.1111/petr.14358
2023Development of an adaptive clinical web-based prediction tool for kidney replacement therapy in children with chronic kidney disease
Kidney International
DOI: 10.1016/j.kint.2023.06.020
2023Perspectives of Pediatric Nephrologists, Intensivists and Nurses Regarding AKI Management and Expected Outcomes
Canadian Journal of Kidney Health and Disease
DOI: 10.1177/20543581231168088
2023The collection of evidence-based data on exercise in the case of solid organ transplantation: How far have we progressed?,La collecte de données probantes sur l’exercice en cas de transplantation d’organe plein: à quel point avons-nous progressé?
Physiotherapy Canada
DOI: 10.3138/ptc-2022-0111-fr
2023Child and caregiver perspectives on access to psychosocial and educational support in pediatric chronic kidney disease: a focus group study
Pediatric Nephrology
Zhang, Y. and Gutman, T. and Tong, A. and Craig, J.C. and Sinha, A. and Dart, A. and Eddy, A.A. and Gipson, D.S. and Bockenhauer, D. and Yap, H.-K. and Groothoff, J. and Zappitelli, M. and J.A.Webb, N. and Alexander, S.I. and Furth, S. and Samuel, S. and Blydt-Hansen, T.D. and Dionne, J. and Michael, M. and Wenderfer, S.E. and Winkelmayer, W.C. and McTaggart, S. and Walker, A. and Zimmerman, C.T. and Ralph, A.F. and Ju, A. and James, L.J. and Hanson, C.S.
DOI: 10.1007/s00467-022-05551-z
2023Building the Evidence for Exercise in Solid Organ Transplant: How Far Have We Moved the Needle?
Physiotherapy Canada
DOI: 10.3138/ptc-2022-0111
2023Revisiting the Application of an Adult Kidney Failure Risk Prediction Equation to Children With CKD
American Journal of Kidney Diseases
DOI: 10.1053/j.ajkd.2022.11.004
2023High urinary CXCL10/Cr with onset of Burkitt lymphoma in a pediatric kidney transplant recipient
Pediatric Transplantation
Shwetha Suresh and David Dix and Li Wang and Tom D. Blydt-Hansen
DOI: 10.1111/petr.14354
11/2022Clinical indicators of slow graft function and outcome after pediatric kidney transplantation
Pediatric Transplantation
Sargun Bajaj and Sharon Gershony and Kourosh Afshar and Tom David Blydt-Hansen
DOI: 10.1111/petr.14353
11/2022The mental health profiles of pediatric organ transplant recipients
Pediatric Transplantation
Erika K. Penner and Hope Walker and Erin Moon and Janine Slavec and Tatsuma Hind and Tom D. Blydt-Hansen
DOI: 10.1111/petr.14151
02/2022Height-adjusted lean body mass and its associations with physical activity and kidney function in pediatric kidney transplantation
Pediatric Transplantation
Azim Ahmed and Anita Cote and Samantha Lui and Tom D. Blydt-Hansen
DOI: 10.1111/petr.14128
02/2022Catecholamines in neuroblastoma: Driver of hypertension, or solely a marker of disease?
Cancer Reports
Harding, M. and Deyell, R.J. and Blydt-Hansen, T.
DOI: 10.1002/cnr2.1569
2022Urinary metabolomics to develop predictors for pediatric acute kidney injury
Pediatric Nephrology
Franiek, A. and Sharma, A. and Cockovski, V. and Wishart, D.S. and Zappitelli, M. and Blydt-Hansen, T.D.
DOI: 10.1007/s00467-021-05380-6
2022Urine Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 to Detect Pediatric Cisplatin-Associated Acute Kidney Injury
Kidney360
DOI: 10.34067/KID.0004802021
2022Self-reported Race, Serum Creatinine, Cystatin C, and GFR in Children and Young Adults With Pediatric Kidney Diseases: A Report From the Chronic Kidney Disease in Children (CKiD) Study
American Journal of Kidney Diseases
Ng, D.K. and Furth, S.L. and Warady, B.A. and Crews, D.C. and Seegmiller, J.C. and Schwartz, G.J. and Fathallah-Shaykh, S. and Nayak, A. and Turman, M. and Blydt-Hansen, T. and Wong, C. and Alexander, S. and Yadin, O. and Ingulli, E. and Mak, R. and Sanchez-Kazi, C. and Moudgil, A. and Gluck, C. and Abitbol, C. and DeFrietas, M. and Katsoufis, C. and Seeherunvong, W. and Greenbaum, L. and Harshman, L. and Langman, C. and Krishnan, S. and Wilson, A. and Kiessling, S. and Murphy, M. and Shah, S. and Sullivan, J. and Gupta, S. and El-Dahr, S. and Drury, S. and Rodig, N. and Dart, A. and Atkinson, M. and Gerson, A. and Matoo, T. and Modi, Z. and Quiroga, A. and Warady, B. and Johnson, R. and Dharnidharka, V. and Hooper, S. and Massengill, S. and Gomez-Mendez, L. and Hand, M. and Carlson, J. and Tawadrous, H. and Jodorkovsky, R. and Wong, C. and Kaskel, F. and Shinnar, S. and Saland, J. and Lande, M. and Schwartz, G. and Mongia, A. and Claes, D. and Mitsnefes, M. and Dell, K. and Patel, H. and Lane, P. and Parekh, R. and Al-Uzri, A. and Richardson, K. and Furth, S. and Copelovitch, L. and Ku, E. and Samuels, J. and Srivaths, P. and Al-Akash, S. and Seo-Mayer, P. and Norwood, V. and Flynn, J. and Pan, C. and Bartosh, S.
DOI: 10.1053/j.ajkd.2021.10.013
2022An Integrated Clinical and Genetic Prediction Model for Tacrolimus Levels in Pediatric Solid Organ Transplant Recipients
Transplantation
Min, S. and Papaz, T. and Lambert, A.N. and Allen, U. and Birk, P. and Blydt-Hansen, T. and Foster, B.J. and Grasemann, H. and Hamiwka, L. and Litalien, C. and Ng, V. and Berka, N. and Campbell, P. and Daniel, C. and Saw, C.L. and Tinckam, K. and Urschel, S. and Van Driest, S.L. and Parekh, R. and Mital, S.
DOI: 10.1097/TP.0000000000003700
2022A review of ferric citrate clinical studies, and the rationale and design of the Ferric Citrate and Chronic Kidney Disease in Children (FIT4KiD) trial
Pediatric Nephrology
Hanudel, M.R. and Laster, M.L. and Portale, A.A. and Dokras, A. and Quigley, R.P. and Guzman, G.A.L. and Zaritsky, J.J. and Hayde, N.A. and Kaskel, F.J. and Mitsnefes, M.M. and Ramirez, J.A. and Imani, P.D. and Srivaths, P.R. and Kogon, A.J. and Denburg, M.R. and Blydt-Hansen, T.D. and Reyes, L.Z. and Greenbaum, L.A. and Weidemann, D.K. and Warady, B.A. and Elashoff, D.A. and Mendley, S.R. and Isakova, T. and Salusky, I.B.
DOI: 10.1007/s00467-022-05492-7
2022The impact of methodological choices when developing predictive models using urinary metabolite data
Statistics in Medicine
Krstic, N. and Multani, K. and Wishart, D.S. and Blydt-Hansen, T. and Cohen Freue, G.V.
DOI: 10.1002/sim.9431
2022A text messaging intervention and quality of life in adolescents with solid organ transplants
Pediatric Transplantation
Rathgeber, S.L. and Hutchison, S.M. and De Souza, A.-M. and Lester, R. and Blydt-Hansen, T. and Human, D.G. and Guttman, O. and Oberlander, T. and Armstrong, K.R.
DOI: 10.1111/petr.14219
2022Long-term respiratory outcomes following solid organ transplantation in children: A retrospective cohort study
Pediatric Pulmonology
Wright, M.F.A. and Blydt-Hansen, T. and Chilvers, M.A.
DOI: 10.1002/ppul.25968
2022Care processes and structures associated with higher medication adherence in adolescent and young adult transplant recipients
Pediatric Transplantation
Anita Dabirzadeh and Mourad Dahhou and Xun Zhang and Ruth Sapir-Pichhadze and Heloise Cardinal and Michel White and Olwyn Johnston and Tom D. Blydt-Hansen and Lee Anne Tibbles and Lorraine Hamiwka and Simon Urschel and Patricia Birk and Janice Bissonnette and Mina Matsuda-Abedini and Jennifer Harrison and Jeffrey Schiff and Veronique Phan and Sabina De Geest and Upton Allen and Seema Mital and Bethany J. Foster
DOI: 10.1111/petr.14106
12/2021Self-reported physical activity and lack of association with health-related quality of life in a pediatric solid-organ transplant population
Pediatric Transplantation
Samantha Lui and Tatsuma Hind and Erin Moon and Astrid de Souza and Katherine Broad and Julie Fairbairn and Richard Schreiber and Kathryn Armstrong and Tom D. Blydt-Hansen
DOI: 10.1111/petr.14093
12/2021Post-traumatic stress as a determinant of quality of life in pediatric solid-organ transplant recipients
Pediatric Transplantation
Tatsuma Hind and Samantha Lui and Erin Moon and Katherine Broad and Samantha Lang and Richard A. Schreiber and Kathryn Armstrong and Tom D. Blydt-Hansen
DOI: 10.1111/petr.14005
06/2021The effects of exercise training in adult solid organ transplant recipients: A systematic review and meta-analysis
Transplant International
Tania Janaudis-Ferreira and Catherine M. Tansey and Sunita Mathur and Tom Blydt-Hansen and Julie Lamoureaux and Agnès Räkel and Nathalia Parente de Sousa Maia and André Bussières and Sara Ahmed and Jill Boruff
DOI: 10.1111/tri.13848
05/2021Patient-reported outcome measures in pediatric solid organ transplantation: Exploring stakeholder perspectives on clinical implementation through qualitative description.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
Anthony SJ and Young K and Pol SJ and Selkirk EK and Blydt-Hansen T and Boucher S and Goldberg A and Hamiwka L and Haverman L and Mitchell J and Urschel S and Santana M and Stinson J and West LJ
DOI: 10.1007/s11136-020-02743-8
PubMed: 33447959
01/2021Design and Methods of the Validating Injury to the Renal Transplant Using Urinary Signatures (VIRTUUS) Study in Children
Transplantation Direct
Kumar, J. and Contrepois, K. and Snyder, M. and Grimm, P.C. and Moudgil, A. and Smith, J.M. and Bobrowski, A.E. and Verghese, P.S. and Hooper, D. and Ingulli, E. and Lestz, R. and Weng, P. and Reason, J.L. and Blydt-Hansen, T.D. and Suthanthiran, M. and Keating, B. and Amaral, S.
DOI: 10.1097/TXD.0000000000001244
2021A Canadian Study of Cisplatin Metabolomics and Nephrotoxicity (ACCENT): A Clinical Research Protocol
Canadian Journal of Kidney Health and Disease
Jain, A. and Huang, R. and Lee, J. and Jawa, N. and Lim, Y.J. and Guron, M. and Abish, S. and Boutros, P.C. and Brudno, M. and Carleton, B. and Cuvelier, G.D.E. and Gunaratnam, L. and Ho, C. and Adeli, K. and Kuruvilla, S. and Lajoie, G. and Liu, G. and Nathan, P.C. and Rod Rassekh, S. and Rieder, M. and Waikar, S.S. and Welch, S.A. and Weir, M.A. and Winquist, E. and Wishart, D.S. and Zorzi, A.P. and Blydt-Hansen, T. and Zappitelli, M. and Urquhart, B.
DOI: 10.1177/20543581211057708
2021High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
Communications Biology
DOI: 10.1038/s42003-021-01989-3
2021Cell sex and sex hormones modulate kidney glucose and glutamine metabolism in health and diabetes
bioRxiv
Clotet-Freixas, S. and Zaslaver, O. and Pastrello, C. and Kotlyar, M. and McEvoy, C. and Farkona, S. and Saha, A. and Boshart, A. and Chan, M. and Riera, M. and Soler, M.J. and Isenbrandt, A. and Lamontagne-Proulx, J. and Pradeloux, S. and Coulombe, K. and Soulet, D. and Dart, A.B. and Wicklow, B. and McGavock, J.M. and Blydt-Hansen, T.D. and Jurisica, I. and Woo, M. and Scholey, J.W. and Röst, H. and Konvalinka, A.
DOI: 10.1101/2021.08.23.457385
2021Association of Urine Platinum With Acute Kidney Injury in Children Treated With Cisplatin for Cancer
Journal of Clinical Pharmacology
Lebel, A. and Chui, H. and McMahon, K.R. and Lim, Y.J. and Macri, J. and Wang, S. and Devarajan, P. and Blydt-Hansen, T.D. and Zappitelli, M. and Urquhart, B.L.
DOI: 10.1002/jcph.1839
2021Risk Factors for Developing Posttransplant Diabetes After Pediatric Kidney Transplant in a Canadian Tertiary Care Children's Hospital Between 1995 and 2016
Canadian Journal of Diabetes
Acosta-Gualandri, A. and Blydt-Hansen, T. and Islam, N. and Amed, S.
DOI: 10.1016/j.jcjd.2021.05.004
2021The Accuracy of Incident Vertebral Fracture Detection in Children Using Targeted Case-Finding Approaches
Journal of Bone and Mineral Research
Ma, J. and Siminoski, K. and Wang, P. and Jaremko, J.L. and Koujok, K. and Matzinger, M.A. and Shenouda, N. and Lentle, B. and Alos, N. and Cummings, E.A. and Ho, J. and Houghton, K. and Miettunen, P.M. and Scuccimarri, R. and Rauch, F. and Ward, L.M. and Ward, L.M. and Konji, V. and Scharke, M. and Sykes, E. and Ho, J. and Kloiber, R. and Lewis, V. and Midgley, J. and Miettunen, P. and Stephure, D. and Lentle, B.C. and Blydt-Hansen, T. and Cabral, D. and Dix, D.B. and Houghton, K. and Nadel, H.R. and Hay, J. and Feber, J. and Halton, J. and Jurencak, R. and Koujok, K. and Matzinger, M. and Roth, J. and Shenouda, N. and Watanabe-Duffy, K. and Cairney, E. and Clarson, C. and Filler, G. and Grimmer, J. and McKillop, S. and Sparrow, K. and Stein, R. and Cummings, E. and Fernandez, C. and Huber, A.M. and Lang, B. and O'Brien, K. and Abish, S. and Bell, L. and LeBlanc, C. and Sbrocchi, A. and Scuccimarri, R. and Moher, D. and Taljaard, M. and Rauch, F. and Alos, N. and Dubois, J. and Laverdiere, C. and Phan, V. and Saint-Cyr, C. and Barsalou, J. and Couch, R. and Ellsworth, J. and Jaremko, J. and Siminoski, K. and Wilson, B. and Grant, R. and Charron, M. and Hebert, D. and Gaboury, I. and Taback, S. and Israels, S. and Oen, K. and Pinsk, M. and Reed, M. and Rodd, C.
DOI: 10.1002/jbmr.4294
2021Isolated diastolic high blood pressure: a distinct clinical phenotype in US children
Pediatric Research
Alsaeed, H. and Metzger, D.L. and Blydt-Hansen, T.D. and Rodd, C. and Sharma, A.
DOI: 10.1038/s41390-021-01369-x
2021Late first acute rejection in pediatric kidney transplantation: A North American Pediatric Renal Trials and Collaborative Studies special study.
Pediatric transplantation
Barton KT and Halani K and Galbiati S and Dandamudi R and Hmiel SP and Dharnidharka VR and NAPRTCS investigators
DOI: 10.1111/petr.13953
PubMed: 33350558
12/2020Age and sex determine conversion from immediate-release to extended-release tacrolimus in a multi-center cohort of Canadian pediatric renal transplant recipients.
Pediatric transplantation
Lang S and Sharma A and Foster B and Gibson IW and Ho J and Nickerson P and Wishart D and Blydt-Hansen T
DOI: 10.1111/petr.13959
PubMed: 33368914
12/2020Biomarker implementation: Evaluation of the decision-making impact of CXCL10 testing in a pediatric cohort.
Pediatric transplantation
Lamarche C and Sharma AK and Goldberg A and Wang L and Blydt-Hansen TD
DOI: 10.1111/petr.13908
PubMed: 33155737
11/2020Management of Pediatric Kidney Transplant Patients During the COVID-19 Pandemic: Guidance From the Canadian Society of Transplantation Pediatric Group.
Canadian journal of kidney health and disease
Teoh CW and Gaudreault-Tremblay MM and Blydt-Hansen TD and Goldberg A and Arora S and Feber J and Langlois V and Ruhl M and Phan V and Morgan C and Acott P and Hamiwka L
DOI: 10.1177/2054358120967845
PubMed: 33240516
11/2020Multicenter data to improve health for pediatric renal transplant recipients in North America: Complementary approaches of NAPRTCS and IROC.
Pediatric transplantation
Hooper DK and Misurac J and Blydt-Hansen T and Chua AN
DOI: 10.1111/petr.13891
PubMed: 33142362
11/2020Investigating oxythiamine levels in children undergoing kidney transplantation and the risk of immediate post-operative metabolic and hemodynamic decompensation.
Pediatric nephrology (Berlin, Germany)
Golan O and Dyer R and Sinclair G and Blydt-Hansen T
DOI: 10.1007/s00467-020-04797-9
PubMed: 33067673
10/2020Validity and utility of urinary CXCL10/Cr immune monitoring in pediatric kidney transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Blydt-Hansen TD and Sharma A and Gibson IW and Wiebe C and Sharma AP and Langlois V and Teoh CW and Rush D and Nickerson P and Wishart D and Ho J
DOI: 10.1111/ajt.16336
PubMed: 33034126
10/2020Yield and utility of surveillance kidney biopsies in pediatric kidney transplant recipients at various time points post-transplant.
Pediatric transplantation
Landsberg A and Riazy M and Blydt-Hansen TD
DOI: 10.1111/petr.13869
PubMed: 33073499
10/2020Long-Term Outcomes of C3 Glomerulopathy and Immune-Complex Membranoproliferative Glomerulonephritis in Children.
Kidney international reports
Kirpalani A and Jawa N and Smoyer WE and Licht C and Midwest Pediatric Nephrology Consortium
DOI: 10.1016/j.ekir.2020.09.019
PubMed: 33305125
10/2020Early surveillance biopsy utilization and management of pediatric renal allograft acute T cell-mediated rejection in Canadian centers: Observations from the PROBE multicenter cohort study.
Pediatric transplantation
Hoffmann AJ and Gibson IW and Ho J and Nickerson P and Rush D and Sharma A and Wishart D and Blydt-Hansen TD
DOI: 10.1111/petr.13870
PubMed: 33026135
10/2020Low renal transplantation rates in children with end-stage kidney disease: A study of barriers in a low-resource setting.
Pediatric transplantation
Pais P and Blydt-Hansen TD and Michael Raj JA and Dello Strologo L and Iyengar A
DOI: 10.1111/petr.13867
PubMed: 33058452
10/2020Adolescents with solid organ transplant: Using the BRIEF2 parent-report and self-report to measure parent-child agreement and everyday executive function.
Applied neuropsychology. Child
Hutchison SM and Rathgeber SL and De Souza AM and Blydt-Hansen T and Mâsse LC and Armstrong KR and Oberlander TF
DOI: 10.1080/21622965.2020.1800468
PubMed: 32758025
08/2020An evaluation of renin-angiotensin system markers in youth with type 2 diabetes and associations with renal outcomes.
Pediatric diabetes
Dart AB and Wicklow B and Scholey J and Sellers EA and Dyck J and Mahmud F and Sochett E and Hamilton J and Blydt-Hansen T and Burns K
DOI: 10.1111/pedi.13081
PubMed: 32657529
07/2020A Canadian Survey on Adverse Symptoms Experienced by Solid Organ Transplant Recipients.
Progress in transplantation (Aliso Viejo, Calif.)
Aladwan S and Harrison JJ and Blackburn DF and Taylor J and Blydt-Hansen TD and Mansell H
DOI: 10.1177/1526924820933821
PubMed: 32597328
06/2020Improving the Care for Pediatric Transplant Patients through Integration of Patient-Reported Outcome Measures into Clinical Practice
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Anthony, S.J. and Young, K. and Pol, S.J. and Blydt-Hansen, T. and Goldberg, A. and Hamiwka, L. and Urschel, S. and Santana, M. and Stinson, J. and West, L.J.
DOI: 10.1016/j.healun.2020.01.1201
2020Epidemiologic Characteristics of Acute Kidney Injury during Cisplatin Infusions in Children Treated for Cancer
JAMA Network Open
DOI: 10.1001/jamanetworkopen.2020.3639
2020Becoming unique: A qualitative study of identity development of adolescent kidney recipients
Pediatric Transplantation
Leblond, M. and Achille, M. and Clermont, M.-J. and Blydt-Hansen, T.
DOI: 10.1111/petr.13607
2020Disseminating Knowledge to Providers on Exercise Training After Solid Organ Transplantation
Progress in Transplantation
Janaudis-Ferreira, T. and Mathur, S. and Tansey, C.M. and Blydt-Hansen, T. and Hartell, D.
DOI: 10.1177/1526924820913506
2020Valganciclovir prophylaxis delays onset of EBV viremia in high-risk pediatric solid organ transplant recipients
Pediatric Research
Albatati, S. and Sharma, A. and Haubrich, K. and Wright, A. and Gantt, S. and Blydt-Hansen, T.D.
DOI: 10.1038/s41390-019-0523-4
2020Physical activity and its correlates in a pediatric solid-organ transplant population
Pediatric Transplantation
Lui, S. and de Souza, A. and Sharma, A. and Fairbairn, J. and Schreiber, R. and Armstrong, K. and Blydt-Hansen, T.
DOI: 10.1111/petr.13745
2020Using Text Messaging to Communicate with Adolescent Heart Transplant Patients
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Rathgeber, S.L. and Hutchison, S. and De Souza, A.M. and Timothy, O. and Galvin, C.R. and Potts, J. and Human, D. and Blydt-Hansen, T. and Lester, R. and Armstrong, K.R.
DOI: 10.1016/j.healun.2020.01.305
2020Evidence for the alloimmune basis and prognostic significance of Borderline T cell–mediated rejection
American Journal of Transplantation
Wiebe, C. and Rush, D.N. and Gibson, I.W. and Pochinco, D. and Birk, P.E. and Goldberg, A. and Blydt-Hansen, T. and Karpinski, M. and Shaw, J. and Ho, J. and Nickerson, P.W.
DOI: 10.1111/ajt.15860
2020A Holistic Approach to Risk for Early Kidney Injury in Indigenous Youth With Type 2 Diabetes: A Proof of Concept Paper From the iCARE Cohort
Canadian Journal of Kidney Health and Disease
Dart, A.B. and Wicklow, B. and Blydt-Hansen, T.D. and Sellers, E.A.C. and Malik, S. and Chateau, D. and Sharma, A. and McGavock, J.M.
DOI: 10.1177/2054358119838836
2019Erratum: Pediatric outcomes in transplant: Personalising immunosuppression to improve efficacy (positive study): the collaboration and design of a national transplant precision medicine program (Transplantation Direct (2018) 4 (e410) DOI: 10.1097/TXD.0000000000000842)
Transplantation Direct
Papaz, T. and Allen, U. and Blydt-Hansen, T. and Birk, P.E. and Min, S. and De Geest, S. and Hamiwka, L. and Phan, V. and Schechter, T. and Wall, D.A. and Urschel, S. and Foster, B.J. and Mital, S.
DOI: 10.1097/TXD.0000000000000864
2019To accompany Banas et al., Time for a Paradigm Shift
EBioMedicine
Sharma, A.K. and Blydt-Hansen, T.D.
DOI: 10.1016/j.ebiom.2019.10.042
2019Kidney transplant practice patterns and outcome benchmarks over 30 years: The 2018 report of the NAPRTCS
Pediatric Transplantation
Chua, A. and Cramer, C. and Moudgil, A. and Martz, K. and Smith, J. and Blydt-Hansen, T. and Neu, A. and Dharnidharka, V.R.
DOI: 10.1111/petr.13597
2019Estimating glomerular filtration rate in youth with obesity and type 2 diabetes: the iCARE study equation
Pediatric Nephrology
Dart, A.B. and McGavock, J. and Sharma, A. and Chateau, D. and Schwartz, G.J. and Blydt-Hansen, T.
DOI: 10.1007/s00467-019-04250-6
2019Resolution of diagnosis and parental attitudes among parents of adolescent kidney recipients
Pediatric Transplantation
Leblond, M. and Achille, M. and Béliveau, M.-J. and Clermont, M.-J. and Blydt-Hansen, T.
DOI: 10.1111/petr.13472
2019Acute Shoshin beriberi syndrome immediately post–kidney transplant with rapid recovery after thiamine administration
Pediatric Transplantation
Elias, I.M. and Sinclair, G. and Blydt-Hansen, T.D.
DOI: 10.1111/petr.13493
2019Risk factors associated with allograft failure in pediatric kidney transplant recipients with focal segmental glomerulosclerosis
Pediatric Transplantation
Koh, L.J. and Martz, K. and Blydt-Hansen, T.D.
DOI: 10.1111/petr.13469
2019Identifying Important Outcomes for Young People With CKD and Their Caregivers: A Nominal Group Technique Study
American Journal of Kidney Diseases
Hanson, C.S. and Gutman, T. and Craig, J.C. and Bernays, S. and Raman, G. and Zhang, Y. and James, L.J. and Ralph, A.F. and Ju, A. and Manera, K.E. and Teixeira-Pinto, A. and Viecelli, A.K. and Alexander, S.I. and Blydt-Hansen, T.D. and Dionne, J. and McTaggart, S. and Michael, M. and Walker, A. and Carter, S. and Wenderfer, S.E. and Winkelmayer, W.C. and Bockenhauer, D. and Dart, A. and Eddy, A.A. and Furth, S.L. and Gipson, D.S. and Goldstein, S.L. and Groothoff, J. and Samuel, S. and Sinha, A. and Webb, N.J.A. and Yap, H.-K. and Zappitelli, M. and Currier, H. and Tong, A.
DOI: 10.1053/j.ajkd.2018.12.040
2019Non-invasive differentiation of non-rejection kidney injury from acute rejection in pediatric renal transplant recipients
Pediatric Transplantation
Archdekin, B. and Sharma, A. and Gibson, I.W. and Rush, D. and Wishart, D.S. and Blydt-Hansen, T.D.
DOI: 10.1111/petr.13364
2019Evolution of renal function and urinary biomarker indicators of inflammation on serial kidney biopsies in pediatric kidney transplant recipients with and without rejection
Pediatric Transplantation
Mincham, C.M. and Gibson, I.W. and Sharma, A. and Wiebe, C. and Mandal, R. and Rush, D. and Nickerson, P. and Ho, J. and Wishart, D.S. and Blydt-Hansen, T.D.
DOI: 10.1111/petr.13202
2018Estimating Time to ESRD in Children With CKD
American Journal of Kidney Diseases
Furth, S.L. and Pierce, C. and Hui, W.F. and White, C.A. and Wong, C.S. and Schaefer, F. and Wühl, E. and Abraham, A.G. and Warady, B.A. and Samuels, J. and Furth, S. and Atkinson, M. and Wilson, A. and Quiroga, A. and Massengill, S. and Selewski, D. and Ferris, M. and Kogon, A. and Kaskel, F. and Lande, M. and Schwartz, G. and Saland, J. and Norwood, V. and Matoo, T. and Hidalgo, G. and Srivaths, P. and Carlson, J. and Langman, C. and Mendley, S. and John, E. and Upadhyay, K. and Seo-Mayer, P. and Patterson, L. and Parekh, R. and Robinson, L. and Weinstein, A. and Samsonov, D. and Kupferman, J. and Misurac, J. and Mongia, A. and Kiessling, S. and Sanchez-Kazi, C. and Dart, A. and Fathallah, S. and Claes, D. and Mitsnefes, M. and Blydt-Hansen, T. and Warady, B. and Greenbaum, L. and Flynn, J. and Wong, C. and Salusky, I. and Yadin, O. and Dell, K. and Jenkins, R. and Pan, C. and Ku, E. and Al-Uzri, A. and Jenkins, R. and Rodig, N. and Wong, C. and Davis, K. and Turman, M. and Bartosh, S. and Hastings, C. and Nayak, A. and Seikaly, M. and Benador, N. and Mak, R. and Wood, E. and Jenkins, R. and Lerner, G. and Barletta, G.M. and Anarat, A. and Bakkaloglu, A. and Ozaltin, F. and Peco-Antic, A. and Querfeld, U. and Gellermann, J. and Sallay, P. and Dro?d?, D. and Bonzel, K.-E. and Wingen, A.-M. and ?urowska, A. and Balasz, I. and Trivelli, A. and Perfumo, F. and Müller-Wiefel, D.E. and Möller, K. and Offner, G. and Enke, B. and Wühl, E. and Hadtstein, C. and Mehls, O. and Schaefer, F. and Emre, S. and Caliskan, S. and Mir, S. and Wygoda, S. and Hohbach-Hohenfellner, K. and Jeck, N. and Klaus, G. and Ardissino, G. and Testa, S. and Montini, G. and Charbit, M. and Niaudet, P. and Caldas-Afonso, A. and Fernandes-Teixeira, A. and Du?ek, J. and Matteucci, M.C. and Picca, S. and Mastrostefano, A. and Wigger, M. and Berg, U.B. and Celsi, G. and Fischbach, M. and Terzic, J. and Fydryk, J. and Urasinski, T. and Coppo, R. and Peruzzi, L. and Arbeiter, K. and Jankauskiené, A. and Grenda, R. and Litwin, M. and Janas, R. and Neuhaus, T.J.
DOI: 10.1053/j.ajkd.2017.12.011
2018Determinants of Readiness for Adopting Healthy Lifestyle Behaviors Among Indigenous Adolescents with Type 2 Diabetes in Manitoba, Canada: A Cross-Sectional Study
Obesity
McGavock, J. and Durksen, A. and Wicklow, B. and Malik, S. and Sellers, E.A.C. and Blydt-Hansen, T. and Chateau, D. and Dart, A.
DOI: 10.1002/oby.22148
2018The prognostic value of urinary chemokines at 6 months after pediatric kidney transplantation
Pediatric Transplantation
Mockler, C. and Sharma, A. and Gibson, I.W. and Gao, A. and Wong, A. and Ho, J. and Blydt-Hansen, T.D.
DOI: 10.1111/petr.13205
2018Practice Patterns in the Treatment and Monitoring of Acute T Cell–Mediated Kidney Graft Rejection in Canada
Canadian Journal of Kidney Health and Disease
Leblanc, J. and Subrt, P. and Paré, M. and Hartell, D. and Sénécal, L. and Blydt-Hansen, T. and Cardinal, H.
DOI: 10.1177/2054358117753616
2018Pediatric outcomes in transplant: Personalising immunosuppression to improve efficacy (POSITIVE Study): The collaboration and design of a national transplant precision medicine program
Transplantation Direct
Papaz, T. and Allen, U. and Blydt-Hansen, T. and Birk, P.E. and Min, S. and Hamiwka, L. and Phan, V. and Schechter, T. and Wall, D.A. and Urschel, S. and Foster, B.J. and Mital, S.
DOI: 10.1097/TXD.0000000000000842
2018Child and Parental Perspectives on Communication and Decision Making in Pediatric CKD: A Focus Group Study
American Journal of Kidney Diseases
Gutman, T. and Hanson, C.S. and Bernays, S. and Craig, J.C. and Sinha, A. and Dart, A. and Eddy, A.A. and Gipson, D.S. and Bockenhauer, D. and Yap, H.-K. and Groothoff, J. and Zappitelli, M. and Webb, N.J.A. and Alexander, S.I. and Goldstein, S.L. and Furth, S. and Samuel, S. and Blydt-Hansen, T. and Dionne, J. and Michael, M. and Wenderfer, S.E. and Winkelmayer, W.C. and Currier, H. and McTaggart, S. and Walker, A. and Ralph, A.F. and Ju, A. and James, L.J. and Carter, S. and Tong, A.
DOI: 10.1053/j.ajkd.2018.05.005
2018Screening for kidney disease in Indigenous Canadian children: The FINISHED screen, triage and treat program
Paediatrics and Child Health (Canada)
Dart, A. and Lavallee, B. and Chartrand, C. and McLeod, L. and Ferguson, T.W. and Tangri, N. and Gordon, A. and Blydt-Hansen, T. and Rigatto, C. and Komenda, P.
DOI: 10.1093/pch/pxy013
2018Non-invasive staging of chronic kidney allograft damage using urine metabolomic profiling
Pediatric Transplantation
Landsberg, A. and Sharma, A. and Gibson, I.W. and Rush, D. and Wishart, D.S. and Blydt-Hansen, T.D.
DOI: 10.1111/petr.13226
2018Successful treatment of chronic norovirus gastroenteritis with nitazoxanide in a pediatric kidney transplant recipient
Pediatric Transplantation
Haubrich, K. and Gantt, S. and Blydt-Hansen, T.
DOI: 10.1111/petr.13186
2018Vitamin D Status in Indigenous Youth with Type 2 Diabetes
Canadian Journal of Diabetes
Melissa Gabbs and Allison Dart and Farrah Jabar and Kristine Kroeker and Tom Blydt-Hansen and Jon Mcgavock and Brandy Wicklow
DOI: 10.1016/j.jcjd.2017.08.207
10/2017Progression and Regression of Albuminuria in Youth with Type 2 Diabetes
Canadian Journal of Diabetes
Farrah Jabar and Brandy Wicklow and Jonathan McGavock and Elizabeth Sellers and Tom Blydt-Hansen and Kristine Kroeker and Dan Chateau and Allison Dart
DOI: 10.1016/j.jcjd.2017.08.025
10/2017Class II eplet mismatch modulates tacrolimus trough levels required to prevent donor-specific antibody development
Journal of the American Society of Nephrology
Wiebe, C. and Rush, D.N. and Nevins, T.E. and Birk, P.E. and Blydt-Hansen, T. and Gibson, I.W. and Goldberg, A. and Ho, J. and Karpinski, M. and Pochinco, D. and Sharma, A. and Storsley, L. and Matas, A.J. and Nickerson, P.W.
DOI: 10.1681/ASN.2017030287
2017Design and methods of the pan-canadian applying biomarkers to minimize long-term effects of childhood/adolescent cancer treatment (ABLE) nephrotoxicity study: A prospective observational cohort study
Canadian Journal of Kidney Health and Disease
McMahon, K.R. and Rassekh, S.R. and Schultz, K.R. and Pinsk, M. and Blydt-Hansen, T. and Mammen, C. and Tsuyuki, R.T. and Devarajan, P. and Cuvelier, G.D.E. and Mitchell, L.G. and Baruchel, S. and Palijan, A. and Carleton, B.C. and Ross, C.J.D. and Zappitelli, M.
DOI: 10.1177/2054358117690338
2017Albuminuria, proteinuria, and renal disease progression in children with CKD
Clinical Journal of the American Society of Nephrology
Fuhrman, D.Y. and Schneider, M.F. and Dell, K.M. and Blydt-Hansen, T.D. and Mak, R. and Saland, J.M. and Furth, S.L. and Warady, B.A. and Moxey-Mims, M.M. and Schwartz, G.J.
DOI: 10.2215/CJN.11971116
2017Evaluation of C1q Status and Titer of De Novo Donor-Specific Antibodies as Predictors of Allograft Survival
American Journal of Transplantation
Wiebe, C. and Gareau, A.J. and Pochinco, D. and Gibson, I.W. and Ho, J. and Birk, P.E. and Blydt-Hansen, T. and Karpinski, M. and Goldberg, A. and Storsley, L. and Rush, D.N. and Nickerson, P.W.
DOI: 10.1111/ajt.14015
2017Adverse symptoms of immunosuppressants: A survey of Canadian transplant clinicians
Clinical Transplantation
Harrison, J.J. and Mansell, H. and Blydt-Hansen, T.
DOI: 10.1111/ctr.12940
2017Urinary Metabolomics for Noninvasive Detection of Antibody-Mediated Rejection in Children after Kidney Transplantation
Transplantation
Blydt-Hansen, T.D. and Sharma, A. and Gibson, I.W. and Wishart, D.S. and Mandal, R. and Ho, J. and Nickerson, P. and Rush, D.
DOI: 10.1097/TP.0000000000001662
2017C1q status and titer of de novo donor specific antibodies are not predictors of allograft survival
Human Immunology
DOI: 10.1016/j.humimm.2016.07.109
09/2016Kidney Disease Progression in Autosomal Recessive Polycystic Kidney Disease.
The Journal of pediatrics
Dell KM and Matheson M and Hartung EA and Warady BA and Furth SL and Chronic Kidney Disease in Children (CKiD) Study
DOI: 10.1016/j.jpeds.2015.12.079
PubMed: 26831744
01/2016Depressive Symptoms in Children with Chronic Kidney Disease
Journal of Pediatrics
Kogon, A.J. and Matheson, M.B. and Flynn, J.T. and Gerson, A.C. and Warady, B.A. and Furth, S.L. and Hooper, S.R. and Dart, A. and Greenbaum, L. and Goebel, J. and Mitsnefes, M. and Wong, C. and Fathallah, S. and Salusky, I. and Yadin, O. and Dell, K. and Morgenstern, B. and Blydt-Hansen, T. and Pan, C. and Davis, K. and Al-Uzri, A. and Jenkins, R. and Portale, A. and Seikaly, M. and Turman, M. and Wong, C. and Alexander, S. and Hastings, C. and Rodig, N. and Harmon, W. and Bartosh, S. and Benador, N. and Mak, R. and Wood, E. and Lerner, G. and Massengill, S. and Hidalgo, G. and Atkinson, M. and Gipson, D. and Srivaths, P. and Samuels, J. and Kaskel, F. and Mattosian, D. and Cai, Y. and Andreoli, S. and Saland, J. and Norwood, V. and Parekh, R. and Robinson, L. and Mendley, S. and Lande, M. and Schwartz, G. and Brophy, P. and John, E. and Upadhyay, K. and Ferris, M. and Matoo, T. and Kupferman, J. and Weiss, L. and Langman, C. and Seo-Mayer, P. and Kher, K. and Samsonov, D.
DOI: 10.1016/j.jpeds.2015.09.040
2016Genetic loci associated with renal function measures and chronic kidney disease in children: The Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium
Nephrology Dialysis Transplantation
Wuttke, M. and Wong, C.S. and Wühl, E. and Epting, D. and Luo, L. and Hoppmann, A. and Doyon, A. and Li, Y. and Sözeri, B. and Thurn, D. and Helmstädter, M. and Huber, T.B. and Blydt-Hansen, T.D. and Kramer-Zucker, A. and Mehls, O. and Melk, A. and Querfeld, U. and Furth, S.L. and Warady, B.A. and Schaefer, F. and Köttgen, A.
DOI: 10.1093/ndt/gfv342
2016Canadian Forum on Combined Organ Transplantation
Transplantation
Cantarovich, M. and Blydt-Hansen, T.D. and Gill, J. and Tinckam, K. and Schiff, J. and Alwayn, I. and Bain, V. and Dipchand, A.I. and Isaac, D. and Kim, S.J. and Lien, D. and Zaltzman, J. and Young, K. and Nickerson, P.
DOI: 10.1097/TP.0000000000000963
2016Elevated urinary CXCL10-to-creatinine ratio is associated with subclinical and clinical rejection in pediatric renal transplantation
Transplantation
Blydt-Hansen, T.D. and Gibson, I.W. and Gao, A. and Dufault, B. and Ho, J.
DOI: 10.1097/TP.0000000000000419
2015Beating Diabetes Together: A Mixed-Methods Analysis of a Feasibility Study of Intensive Lifestyle Intervention for Youth with Type 2 Diabetes
Canadian Journal of Diabetes
Huynh, E. and Rand, D. and McNeill, C. and Brown, S. and Senechal, M. and Wicklow, B. and Dart, A. and Sellers, E. and Dean, H. and Blydt-Hansen, T. and McGavock, J.
DOI: 10.1016/j.jcjd.2015.09.093
2015Rates and determinants of progression to graft failure in kidney allograft recipients with de novo donor-specific antibody
American Journal of Transplantation
Wiebe, C. and Gibson, I.W. and Blydt-Hansen, T.D. and Pochinco, D. and Birk, P.E. and Ho, J. and Karpinski, M. and Goldberg, A. and Storsley, L. and Rush, D.N. and Nickerson, P.W.
DOI: 10.1111/ajt.13347
2015Progression of pediatric CKD of nonglomerular origin in the CKiD cohort
Clinical Journal of the American Society of Nephrology
Fathallah-Shaykh, S.A. and Flynn, J.T. and Pierce, C.B. and Abraham, A.G. and Blydt-Hansen, T.D. and Massengill, S.F. and Moxey-Mims, M.M. and Warady, B.A. and Furth, S.L. and Wong, C.S.
DOI: 10.2215/CJN.07480714
2015Description of a Novel Collaborative Joint Pediatric Renal and Type 2 Diabetes Clinic
Canadian Journal of Diabetes
Megan Bale and Tom Blydt-Hansen and Julie Halipchuk and Allison Dart and Brandy Wicklow
DOI: 10.1016/j.jcjd.2014.07.093
10/2014Guidance on the use of increased infectious risk donors for organ transplantation.
Transplantation
DOI: 10.1097/tp.0000000000000251
PubMed: 25243510
08/2014Effect of sirolimus on malignancy and survival after kidney transplantation: Systematic review and meta-analysis of individual patient data
BMJ (Online)
Knoll, G.A. and Kokolo, M.B. and Mallick, R. and Beck, A. and Buenaventura, C.D. and Ducharme, R. and Barsoum, R. and Bernasconi, C. and Blydt-Hansen, T.D. and Ekberg, H. and Felipe, C.R. and Firth, J. and Gallon, L. and Gelens, M. and Glotz, D. and Gossmann, J. and Guba, M. and Morsy, A.A. and Salgo, R. and Scheuermann, E.H. and Tedesco-Silva, H. and Vitko, S. and Watson, C. and Fergusson, D.A.
DOI: 10.1136/bmj.g6679
2014The Improving Renal Complications in Adolescents With Type 2 Diabetes Through the REsearch (iCARE) Cohort Study: Rationale and Protocol
Canadian Journal of Diabetes
Dart, A.B. and Wicklow, B.A. and Sellers, E.A. and Dean, H.J. and Malik, S. and Walker, J. and Chateau, D. and Blydt-Hansen, T.D. and McGavock, J.M.
DOI: 10.1016/j.jcjd.2014.07.224
2014Meeting report: Consensus recommendations for a research agenda in exercise in solid organ transplantation
American Journal of Transplantation
DOI: 10.1111/ajt.12874
2014Skeletal findings in the first 12 months following initiation of glucocorticoid therapy for pediatric nephrotic syndrome
Osteoporosis International
Phan, V. and Blydt-Hansen, T. and Feber, J. and Alos, N. and Arora, S. and Atkinson, S. and Bell, L. and Clarson, C. and Couch, R. and Cummings, E.A. and Filler, G. and Grant, R.M. and Grimmer, J. and Hebert, D. and Lentle, B. and Ma, J. and Matzinger, M. and Midgley, J. and Pinsk, M. and Rodd, C. and Shenouda, N. and Stein, R. and Stephure, D. and Taback, S. and Williams, K. and Rauch, F. and Siminoski, K. and Ward, L.M. and Halton, J. and Jurencak, R. and Roth, J. and Moher, D. and Ramsay, T. and Kloiber, R. and Lewis, V. and Miettunen, P. and Cabral, D. and Dix, D.B. and Houghton, K. and Nadel, H.R. and Hay, J. and Cairney, E. and Sparrow, K. and Fernandez, C. and Huber, A.M. and Lang, B. and O'Brien, K. and Barr, R. and Coblentz, C. and Dent, P.B. and Larche, M. and Webber, C. and Abish, S. and Scuccimarri, R. and Glorieux, F. and Dubois, J. and Laverdière, C. and Saint-Cyr, C. and Ellsworth, J. and LeBlanc, C. and Wilson, B. and Charron, M. and Gaboury, I. and Israels, S. and Oen, K. and Reed, M.
DOI: 10.1007/s00198-013-2466-7
2014Medication treatment complexity and adherence in children with CKD
Clinical Journal of the American Society of Nephrology
Blydt-Hansen, T.D. and Pierce, C.B. and Cai, Y. and Samsonov, D. and Massengill, S. and Moxey-Mims, M. and Warady, B.A. and Furth, S.L.
DOI: 10.2215/CJN.05750513
2014Antibody-mediated rejection: Analyzing the risk, proposing solutions
Transplantation
Arias, M. and Rush, D.N. and Wiebe, C. and Gibson, I.W. and Blydt-Hansen, T.D. and Nickerson, P.W. and Sellarés, J. and López-Hoyos, M. and San Segundo, D. and Crespo-Leiro, M.G. and Marzoa-Rivas, R. and Barge-Caballero, E. and Paniagua-Martín, M.J. and Román, A. and Serón, D. and Böhmig, G. and Schwaiger, E.
DOI: 10.1097/TP.0000000000000218
2014Urinary metabolomics for noninvasive detection of borderline and acute T cell-mediated rejection in children after kidney transplantation
American Journal of Transplantation
Blydt-Hansen, T.D. and Sharma, A. and Gibson, I.W. and Mandal, R. and Wishart, D.S.
DOI: 10.1111/ajt.12837
2014How should we identify early chronic kidney disease risk in non-kidney transplant recipients?
Pediatric Transplantation
Blydt-Hansen, T.D. and Dart, A.B.
DOI: 10.1111/petr.12356
2014Evidence for the use of glomerulomegaly as a surrogate marker of glomerular damage and for alpha-linolenic acid-rich oils in the treatment of early obesity-related glomerulopathy in a diet-induced rodent model of obesity
Applied Physiology, Nutrition and Metabolism
Caligiuri, S.P.B. and Blydt-Hansen, T. and Love, K. and Grégoire, M. and Taylor, C.G. and Zahradka, P. and Aukema, H.M.
DOI: 10.1139/apnm-2013-0476
2014Canadian society of nephrology commentary on the 2012 KDIGO clinical practice guideline for the management of blood pressure in CKD
American Journal of Kidney Diseases
Ruzicka, M. and Quinn, R.R. and McFarlane, P. and Hemmelgarn, B. and Ramesh Prasad, G.V. and Feber, J. and Nesrallah, G. and Mackinnon, M. and Tangri, N. and McCormick, B. and Tobe, S. and Blydt-Hansen, T.D. and Hiremath, S.
DOI: 10.1053/j.ajkd.2014.03.003
2014The impact of short stature on health-related quality of life in children with chronic kidney disease.
The Journal of pediatrics
Al-Uzri A and Matheson M and Gipson DS and Mendley SR and Hooper SR and Yadin O and Rozansky DJ and Moxey-Mims M and Furth SL and Warady BA and Gerson AC and Chronic Kidney Disease in Children Study Group
DOI: 10.1016/j.jpeds.2013.03.016
PubMed: 23628375
04/2013Substantial practice variation exists in the management of childhood nephrotic syndrome
Pediatric Nephrology
Samuel, S. and Morgan, C.J. and Bitzan, M. and Mammen, C. and Dart, A.B. and Manns, B.J. and Alexander, R.T. and Erickson, R.L. and Grisaru, S. and Wade, A.W. and Blydt-Hansen, T. and Feber, J. and Arora, S. and Licht, C. and Zappitelli, M.
DOI: 10.1007/s00467-013-2546-0
2013Association of income level with kidney disease severity and progression among children and adolescents with CKD: A report from the chronic kidney disease in children (CKiD) study
American Journal of Kidney Diseases
Hidalgo, G. and Ng, D.K. and Moxey-Mims, M. and Minnick, M.L. and Blydt-Hansen, T. and Warady, B.A. and Furth, S.L.
DOI: 10.1053/j.ajkd.2013.06.013
2013Class II HLA epitope matching - A strategy to minimize de novo donor-specific antibody development and improve outcomes
American Journal of Transplantation
Wiebe, C. and Pochinco, D. and Blydt-Hansen, T.D. and Ho, J. and Birk, P.E. and Karpinski, M. and Goldberg, A. and Storsley, L.J. and Gibson, I.W. and Rush, D.N. and Nickerson, P.W.
DOI: 10.1111/ajt.12478
2013The development of bone mineral lateralization in the arms
Osteoporosis International
Siminoski, K. and Lee, K.-C. and Abish, S. and Alos, N. and Bell, L. and Blydt-Hansen, T. and Couch, R. and Cummings, E.A. and Ellsworth, J. and Feber, J. and Fernandez, C.V. and Halton, J. and Huber, A.M. and Israels, S. and Jurencak, R. and Lang, B. and Laverdière, C. and Leblanc, C. and Lewis, V. and Midgley, J. and Miettunen, P.M. and Oen, K. and Phan, V. and Pinsk, M. and Rauch, F. and Rodd, C. and Roth, J. and Saint-Cyr, C. and Scuccimarri, R. and Stephure, D. and Taback, S. and Wilson, B. and Ward, L.M.
DOI: 10.1007/s00198-012-2054-2
2013Dietary linoleic acid and a-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats
Journal of Nutrition
Caligiuri, S.P.B. and Love, K. and Winter, T. and Gauthier, J. and Taylor, C.G. and Blydt-Hansen, T. and Zahradka, P. and Aukema, H.M.
DOI: 10.3945/jn.113.177360
2013Pediatric kidney transplant practice patterns and outcome benchmarks, 1987-2010: A report of the North American Pediatric Renal Trials and Collaborative Studies
Pediatric Transplantation
Smith, J.M. and Martz, K. and Blydt-Hansen, T.D.
DOI: 10.1111/petr.12034
2013Assessment of identity and quality of life in diabetic and renal transplant adolescents in comparison to healthy adolescents
Journal of Clinical Psychology in Medical Settings
Lugasi, T. and Achille, M. and Blydt-Hansen, T. and Clermont, M.-J. and Geoffroy, L. and Legault, L. and Phan, V. and Bell, L.E.
DOI: 10.1007/s10880-012-9344-x
2013Incident vertebral fractures among children with rheumatic disorders 12 months after glucocorticoid initiation: a national observational study.
Arthritis care & research
DOI: 10.1002/acr.20589
PubMed: 22213727
01/2012Skeletal findings in children recently initiating glucocorticoids for the treatment of nephrotic syndrome
Osteoporosis International
Feber, J. and Gaboury, I. and Ni, A. and Alos, N. and Arora, S. and Bell, L. and Blydt-Hansen, T. and Clarson, C. and Filler, G. and Hay, J. and Hebert, D. and Lentle, B. and Matzinger, M. and Midgley, J. and Moher, D. and Pinsk, M. and Rauch, F. and Rodd, C. and Shenouda, N. and Siminoski, K. and Ward, L.M.
DOI: 10.1007/s00198-011-1621-2
2012Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant
American Journal of Transplantation
Wiebe, C. and Gibson, I.W. and Blydt-Hansen, T.D. and Karpinski, M. and Ho, J. and Storsley, L.J. and Goldberg, A. and Birk, P.E. and Rush, D.N. and Nickerson, P.W.
DOI: 10.1111/j.1600-6143.2012.04013.x
2012Reliability of resting blood pressure measurement and classification using an oscillometric device in children with chronic kidney disease.
The Journal of pediatrics
Flynn JT and Pierce CB and Miller ER and Charleston J and Samuels JA and Kupferman J and Furth SL and Warady BA and Chronic Kidney Disease in Children Study Group
DOI: 10.1016/j.jpeds.2011.08.071
PubMed: 22048052
11/2011Pretransplant serologic testing to identify the risk of polyoma BK viremia in pediatric kidney transplant recipients
Pediatric Transplantation
Ali, A.M. and Gibson, I.W. and Birk, P. and Blydt-Hansen, T.D.
DOI: 10.1111/j.1399-3046.2011.01583.x
2011Transplantation outcomes in primary hyperoxaluria.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Bergstralh EJ and Monico CG and Lieske JC and Herges RM and Langman CB and Hoppe B and Milliner DS and IPHR Investigators
DOI: 10.1111/j.1600-6143.2010.03271.x
PubMed: 20849551
09/2010Canadian Society of Transplantation and Canadian Society of Nephrology commentary on the 2009 KDIGO clinical practice guideline for the care of kidney transplant recipients
American Journal of Kidney Diseases
Knoll, G.A. and Blydt-Hansen, T.D. and Campbell, P. and Cantarovich, M. and Cole, E. and Fairhead, T. and Gill, J.S. and Gourishankar, S. and Hebert, D. and Hodsman, A. and House, A.A. and Humar, A. and Karpinski, M. and Kim, S.J. and Mainra, R. and Prasad, G.V.R.
DOI: 10.1053/j.ajkd.2010.05.004
2010Policy statement of canadian society of transplantation and canadian society of nephrology on organ trafficking and transplant tourism
Transplantation
Gill, J.S. and Goldberg, A. and Prasad, G.V.R. and Fortin, M.-C. and Hansen, T.-B. and Levin, A. and Gill, J. and Tonelli, M. and Tibbles, L.A. and Knoll, G. and Cole, E.H. and Caulfield, T.
DOI: 10.1097/TP.0b013e3181efd030
2010Masked hypertension associates with left ventricular hypertrophy in children with CKD
Journal of the American Society of Nephrology
Mitsnefes, M. and Flynn, J. and Cohn, S. and Samuels, J. and Blydt-Hansen, T. and Saland, J. and Kimball, T. and Furth, S. and Warady, B.
DOI: 10.1681/ASN.2009060609
2010Prevalent vertebral fractures among children initiating glucocorticoid therapy for the treatment of rheumatic disorders
Arthritis Care and Research
Huber, A.M. and Gaboury, I. and Cabral, D.A. and Lang, B. and Ni, A. and Stephure, D. and Taback, S. and Dent, P. and Ellsworth, J. and LeBlanc, C. and Saint-Cyr, C. and Scuccimarri, R. and Hay, J. and Lentle, B. and Matzinger, M. and Shenouda, N. and Moher, D. and Rauch, F. and Siminoski, K. and Ward, L.M. and Feber, J. and Halton, J. and Roth, J. and Kloiber, R. and Lewis, V. and Midgley, J. and Miettunen, P. and Dix, D.B. and Houghton, K. and Nadel, H.R. and White, C. and Clarson, C. and Stein, R. and Cairney, E. and Filler, G. and Grimmer, J. and Sparrow, K. and Cummings, E. and Fernandez, C. and O'Brien, K. and Ross, A. and Atkinson, S. and Arora, S. and Barr, R. and Coblentz, C. and Webber, C. and Rodd, C. and Abish, S. and Bell, L. and Glorieux, F. and Alos, N. and Dubois, J. and Laverdière, C. and Phan, V. and Couch, R. and Pinsk, M. and Wilson, B. and Grant, R. and Charron, M. and Hebert, D. and Blydt-Hansen, T. and Israels, S. and Oen, K. and Reed, M.
DOI: 10.1002/acr.20171
2010Histological progression of chronic renal allograft injury comparing sirolimus and mycophenolate mofetil-based protocols. A single-center, prospective, randomized, controlled study
Pediatric Transplantation
Blydt-Hansen, T.D. and Gibson, I.W. and Birk, P.E.
DOI: 10.1111/j.1399-3046.2010.01374.x
2010Enhanced resolution of interstitial fibrosis in pediatric renal allograft biopsies using image analysis of trichrome stain
Pediatric Transplantation
Birk, P.E. and Gill, J.S. and Blydt-Hansen, T.D. and Gibson, I.W.
DOI: 10.1111/j.1399-3046.2010.01376.x
2010The Use of Immunoglobulin Therapy for Patients Undergoing Solid Organ Transplantation: An Evidence-Based Practice Guideline
Transfusion Medicine Reviews
Shehata, N. and Palda, V.A. and Meyer, R.M. and Blydt-Hansen, T.D. and Campbell, P. and Cardella, C. and Martin, S. and Nickerson, P. and Peltekian, K. and Ross, H. and Waddell, T.K. and West, L. and Anderson, D. and Freedman, J. and Hume, H.
DOI: 10.1016/j.tmrv.2009.09.010
2010Patterns of chronic injury in pediatric renal allografts
Transplantation
Dart, A.B. and Schall, A. and Gibson, I.W. and Blydt-Hansen, T.D. and Birk, P.E.
DOI: 10.1097/TP.0b013e3181bc5e49
2010Advanced vertebral fracture among newly diagnosed children with acute lymphoblastic leukemia: Results of the Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) research program
Journal of Bone and Mineral Research
Halton, J. and Gaboury, I. and Grant, R. and Alos, N. and Cummings, E.A. and Matzinger, M. and Shenouda, N. and Lentle, B. and Abish, S. and Atkinson, S. and Cairney, E. and Dix, D. and Israels, S. and Stephure, D. and Wilson, B. and Hay, J. and Moher, D. and Rauch, F. and Siminoski, K. and Ward, L.M. and Feber, J. and Roth, J. and Kloiber, R. and Lewis, V. and Midgley, J. and Miettunen, P. and Cabral, D. and Nadel, H.R. and White, C. and Clarson, C. and Filler, G. and Grimmer, J. and Sparrow, K. and Fernandez, C. and Huber, A.M. and Lang, B. and O'Brien, K. and Ross, A. and Arora, S. and Barr, R. and Coblentz, C. and Dent, P.B. and Webber, C. and Rodd, C. and Bell, L. and Scuccimarri, R. and Glorieux, F. and Dubois, J. and Laverdière, C. and Phan, V. and Saint-Cyr, C. and Couch, R. and Ellsworth, J. and LeBlanc, C. and Pinsk, M. and Charron, M. and Hebert, D. and Taback, S. and Blydt-Hansen, T. and Oen, K. and Reed, M.
DOI: 10.1359/jbmr.090202
2009The concurrent presentation of minimal change nephrotic syndrome and aplastic anemia
Pediatric Nephrology
Abrams, E.M. and Gibson, I.W. and Blydt-Hansen, T.D.
DOI: 10.1007/s00467-008-0994-8
2009Impact of socioeconomic status on the prevalence of dementia in an inner city memory disorders clinic
International Psychogeriatrics
Fischer, C. and Yeung, E. and Hansen, T. and Gibbons, S. and Fornazzari, L. and Ringer, L. and Schweizer, T.A.
DOI: 10.1017/S1041610209990846
2009Macroalbuminuria and renal pathology in first nation youth with type 2 diabetes
Diabetes Care
Sellers, E.A.C. and Blydt-Hansen, T.D. and Dean, H.J. and Gibson, I.W. and Birk, P.E. and Ogborn, M.
DOI: 10.2337/dc08-1828
2009Knowledge of Alzheimer's disease and subjective memory impairment in Latin American seniors in the Greater Toronto Area
International Psychogeriatrics
Fornazzari, L. and Fischer, C. and Hansen, T. and Ringer, L.
DOI: 10.1017/S1041610209990433
2009Changes in height, BMI and bone density in children with nephrotic syndrome during six months prospective follow-up
American Society of Nephrology
2008Low incidence of adverse events in outpatient pediatric renal allograft biopsies
Pediatric Transplantation
Birk, P.E. and Blydt-Hansen, T.D. and Dart, A.B. and Kaita, L.M. and Proulx, C. and Taylor, G.
DOI: 10.1111/j.1399-3046.2006.00659.x
2007Pediatric ESRD in Canada: A review of the last quarter century
CIHI Annual Report
2007Biopsy-proven acute tubular necrosis in a child attributed to vancomycin intoxication
Pediatric Nephrology
Wicklow, B.A. and Ogborn, M.R. and Gibson, I.W. and Blydt-Hansen, T.D.
DOI: 10.1007/s00467-006-0152-0
2006Canadian Society of Transplantation consensus guidelines on eligibility for kidney transplantation
CMAJ
Knoll, G. and Cockfield, S. and Blydt-Hansen, T. and Baran, D. and Kiberd, B. and Landsberg, D. and Rush, D. and Cole, E.
DOI: 10.1503/cmaj.051291
2005Canadian Society of Transplantation: consensus guidelines on eligibility for kidney transplantation.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
DOI: 10.1503/cmaj.1041588
2005Erratum: Canadian Society of Transplantation consensus guidelines on eligibility for kidney transplantation (Canadian Medical Association Journal (2005) 173, 10 (1181-1184)) DOI: 10.1503/cmaj.051291
CMAJ
Knoll, G. and Cockfield, S. and Blydt-Hansen, T.
DOI: 10.1503/cmaj.051428
2005Surveillance biopsies are superior to functional studies for the diagnosis of acute and chronic renal allograft pathology in children
Pediatric Transplantation
Birk, P.E. and Stannard, K.M. and Konrad, H.B. and Blydt-Hansen, T.D. and Ogborn, M.R. and Cheang, M.S. and Gartner, J.G. and Gibson, I.W.
DOI: 10.1046/j.1397-3142.2003.00122.x
2004Children are not small adults.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
PubMed: 12566324
02/2003Children are not small adults [1]
CMAJ
Dean, H. and Sellers, E. and Birk, P. and Blydt-Hansen, T. and Ogborn, M. and Tobe, S.
2003Gene transfer-induced local heme oxygenase-1 overexpression protects rat kidney transplants from ischemia/reperfusion injury
Journal of the American Society of Nephrology
Blydt-Hansen, T.D. and Katori, M. and Lassman, C. and Ke, B. and Coito, A.J. and Iyer, S. and Buelow, R. and Ettenger, R. and Busuttil, R.W. and Kupiec-Weglinski, J.W.
DOI: 10.1097/01.ASN.0000050760.87113.25
2003Recovery of respiratory syncytial virus from stethoscopes by conventional viral culture and polymerase chain reaction
Pediatric Infectious Disease Journal
Blydt-Hansen, T. and Subbarao, K. and Quennec, P. and McDonald, J.
DOI: 10.1097/00006454-199902000-00017
1999PHEX expression in parathyroid gland and parathyroid hormone dysregulation in X-linked hypophosphatemia
Pediatric Nephrology
Blydt-Hansen, T.D. and Tenenhouse, H.S. and Goodyer, P.
DOI: 10.1007/s004670050669
1999 - Research
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The CNTRP (Canadian National Transplant Research Program)
is a CIHR co-funded large network of researchers who are collectively undertaking 6 unique research programs that are supported by 3 cores. This includes a pediatric solid organ transplant research program that will focus on age and developmental changes in the immune system, drug pharmacokinetics, viral infection susceptibility and systems-related issues affecting adherence across the spectrum of mid and late-adolescence.The PROBE Multicenter Cohort study
(Pediatric Renal transplant Optimization using BiomarkErs) is a CHIR funded program to identify urine biomarkers of kidney allograft injury such as acute rejection, in children after kidney transplantation. It follows on an initial cohort study that has identified urinary chemokines and metabolite profiles that accurately detect acute rejecton. The current study will validate these findings in a multi-center cohort, establish the time-course for appearance and disappearance of "risk" signals in the first year after transplant, and deterimine the whether these events which are not otherwise detectable are associated with worse long-term outcome as measured by histology, kidney function and development of de novo donor-specific antibodies.GrantsCanadian Institutes of Health Research (CIHR) “Applying Biomarkers to Long-term Effects in Child and Adolescent Cancer Treatment (ABLE Team).” Oct 2011-Sep 2016. PI: Schultz, Kirk Raymond, Tom Blydt-Hansen (collaborator), L.R. Brandao, R. Broady, B.C. Carleton, G. Cuvelier, M.R. Hayden, A.Y.Y. Lee, M.N.Pinsk, C.J.D. Ross, M. Spavor.
Astellas Pharma Canada, Inc. “PROBE-Adherence: Therapeutic drug exposure and outcome in pediatric kidney transplant recipients converting from twice-daily tacrolimus to daily extended-release tacrolimus.” Apr 2014- Sept 2018. PI: Tom Blydt-Hansen, Beth Foster, Ian Gibson, Julie Ho, Peter Nickerson, Atul Sharma, David Wishart.
Canadian Diabetes Association “Improving cardiovascular risk in adolescents with diabetes through research (iCARE).” Jan 2011-Dec 2014. PI: Allison Dart, Tom Blydt-Hansen (co-investigator), J. McGavock, E. Sellers, H. Dean.
Children's Hospital Foundation of Manitoba. "Pediatric Kidney Health and Transplant Education Resource: Pre-Transplant". December 2014. April 1 2015 - March 30 2016. PI: Julie Strong, Tom Blydt-Hansen.
Canadian Institutes of Health Research (CIHR) “Non-Invasive monitoring of pediatric kidney allograft injury to improve diagnosis and patient outcomes” Oct 2012- Sep 2017. PI: Tom Blydt-Hansen, Julie Ho, Peter Nickerson, David Wishart, Ian Gibson.
Canadian Institutes of Health Research (CIHR) “Canadian National Transplant Research Program (CNTRP).” Apr 2013- Mar 2018. PI: West L. Caulfield T, Hebert MJ, Humar A, Knoll G, Levings M, Mital S, Roy DC, Schultz K, Shapiro J, Tom Blydt-Hansen.
Astellas Canada "PROBE Adherence: Therapeutic drug exposure and outcome in pediatric kidney transplant recipients converting from twice-daily tacrolimus to daily extended-release tacrolimus". June 2014 - May 2018. PI: Tom Blydt-Hansen.
Research Group MembersDavid Camarda, Research Undergraduate Student
Ella Chan, Research Assistant
Serena Chan, TBH Lab Trainee
Caitlyn Chan, TBH Lab Student Volunteer
Irene Chen, TBH Master's Student
Victoria Chong, TBH Lab Student Volunteer
Michael Collins
Bita Ghorbani, Research Assistant
Bhavana Gourish, MOT Research Assistant
Mike Guron, Research Staff
Renee Hui, TBH Lab Volunteer
Parsa Khanbadr, TBH Student Volunteer
Linda Li, Research Assistant
Phillip Ly, SOT Research Volunteer
Jasmin Malhi, Masters Student
Minh Nguyen, TBH Worklearn Student
Isabella Parrotta, Research Assistant
Angela Siemens, TBH Lab Medical Student
Amy Thachil, Research Assistant
William Wang, Clinical Resident
Christopher Yu, TBH Lab Undergraduate Student
Exploring the ethics of direct contact between pediatric transplant recipients and donors
Non-anonymized direct contact between organ recipients and donor families is a topic of international interest in the adult context but there has been very little research on direct contact in the pediatric context.
