Overview

I grew up and took my basic medical training in what used to be called Rhodesia (now Zimbabwe). After graduating, I worked as a district health doctor in remote rural hospitals. My continuing interest in the health of people living in poverty dates to that time. After moving to Canada with my family, I worked as a resident at BC Children's Hospital before taking further sub-specialty training in pediatric respiratory diseases plus a second fellowship in pediatric intensive care. After completing this training I joined the BC Children's Hospital

staff, splitting my time between the intensive care unit and the respiratory division. More recently, I have left the ICU and I am currently the head of the division of respiratory medicine.

My research interests reflect my past clinical experience. My primary interest has always been international health. I have published two books on the subject and also teach a credit course on international health at UBC. I currently run a large multi-centre trial in India looking into childhood pneumonia. I also like investigating topical questions in clinical respiratory medicine, including the very specialised respiratory topic of children that need mechanical ventilation in their homes.

Publications

Predictive Accuracy of Chest Radiographs in Diagnosing Tachypneic Children.
Seear M, Awasthi S, Gowraiah V, Kapoor R, Awasthi A, Verma A, Al-Shabibi S, Gowdy C
DOI: 10.1007/s12098-016-2057-7
PubMed: 26935199
09/2016

The quality of life of home-ventilated children and their primary caregivers plus the associated social and economic burdens: a prospective study.
Seear M, Kapur A, Wensley D, Morrison K, Behroozi A
DOI: 10.1136/archdischild-2015-309796
PubMed: 26940814
07/2016

Casting a look at pediatric plastic bronchitis.
Jasinovic T, Kozak FK, Moxham JP, Chilvers M, Wensley D, Seear M, Campbell A, Ludemann JP
DOI: 10.1016/j.ijporl.2015.07.011
PubMed: 26250441
10/2015

Can we distinguish pneumonia from wheezy diseases in tachypnoeic children under low-resource conditions? A prospective observational study in four Indian hospitals.
Gowraiah V, Awasthi S, Kapoor R, Sahana D, Venkatesh P, Gangadhar B, Awasthi A, Verma A, Pai N, Seear M
DOI: 10.1136/archdischild-2013-305740
PubMed: 24925892
10/2014

Combined immunodeficiency associated with homozygous MALT1 mutations.
McKinnon ML, Rozmus J, Fung SY, Hirschfeld AF, Del Bel KL, Thomas L, Marr N, Martin SD, Marwaha AK, Priatel JJ, Tan R, Senger C, Tsang A, Prendiville J, Junker AK, Seear M, Schultz KR, Sly LM, Holt RA, Patel MS
DOI: 10.1016/j.jaci.2013.10.045
PubMed: 24332264
05/2014

Long-term ventilation in children: longitudinal trends and outcomes.
McDougall CM, Adderley RJ, Wensley DF, Seear MD
DOI: 10.1136/archdischild-2012-303062
PubMed: 23838128
09/2013

The need for coordinated action against falsified and substandard medicines.
Seear M
DOI: 10.5588/ijtld.12.0988
PubMed: 23407216
03/2013

Bronchial balloon occlusion in children with complex pulmonary air leaks.
Hathorn C, Armitage N, Wensley D, Seear M
DOI: 10.1136/archdischild-2012-302529
PubMed: 23220206
02/2013

Superior herniation of the mediastinum presenting as an anterior neck mass on straining.
McDougall CM, Culham G, Seear MD, Chilvers MA
DOI: 10.1002/ppul.21618
PubMed: 22415969
07/2012

Pharmaceutical quality: an urgent and unresolved issue.
Seear M
DOI: 10.1016/s1473-3099(12)70080-4
PubMed: 22632180
06/2012

Fifty years of pediatric asthma in developed countries: how reliable are the basic data sources?
Chawla J, Seear M, Zhang T, Smith A, Carleton B
DOI: 10.1002/ppul.21537
PubMed: 21905263
03/2012

The need for better data about counterfeit drugs in developing countries: a proposed standard research methodology tested in Chennai, India.
Seear M, Gandhi D, Carr R, Dayal A, Raghavan D, Sharma N
DOI: 10.1111/j.1365-2710.2010.01198.x
PubMed: 21729113
08/2011

Predicting major adverse events after cardiac surgery in children.
Seear MD, Scarfe JC, LeBlanc JG
DOI: 10.1097/pcc.0b013e31818d1971
PubMed: 18838931
11/2008

Wilson-Mikity syndrome: updated diagnostic criteria based on nine cases and a review of the literature.
Hoepker A, Seear M, Petrocheilou A, Hayes D, Nair A, Deodhar J, Kadam S, O'Toole J
DOI: 10.1002/ppul.20900
PubMed: 18781642
10/2008

Iatrogenic hyponatremia in hospitalized children: Can it be avoided?
Skippen P, Adderley R, Bennett M, Cogswell A, Froese N, Seear M, Wensley D
PubMed: 19436422
07/2008

How accurate is the diagnosis of exercise induced asthma among Vancouver schoolchildren?
Seear M, Wensley D, West N
DOI: 10.1136/adc.2004.063974
PubMed: 15855180
09/2005

History's lessons.
Seear M
DOI: 10.1503/cmaj.1040727
PubMed: 15583199
12/2004

Life-threatening human metapneumovirus pneumonia requiring extracorporeal membrane oxygenation in a preterm infant.
Ulloa-Gutierrez R, Skippen P, Synnes A, Seear M, Bastien N, Li Y, Forbes JC
DOI: 10.1542/peds.2004-0345
PubMed: 15466079
10/2004

Citrate anticoagulation in pediatric continuous venovenous hemofiltration.
Elhanan N, Skippen P, Nuthall G, Krahn G, Seear M
DOI: 10.1007/s00467-003-1328-5
PubMed: 14669096
02/2004

A controlled study of postpartum depression among Nepalese women: validation of the Edinburgh Postpartum Depression Scale in Kathmandu.
Regmi S, Sligl W, Carter D, Grut W, Seear M
DOI: 10.1046/j.1365-3156.2002.00866.x
PubMed: 11952955
04/2002

Citrate anticoagulation in a piglet model of pediatric continuous renal replacement therapy.
Nuthall G, Skippen P, Daoust C, Al-Jofan F, Seear M
DOI: 10.1097/00003246-200204000-00031
PubMed: 11940766
04/2002

Acellular bronchial casts in children after cardiac surgery.
Seear M
DOI: 10.1097/00003246-200102000-00065
PubMed: 11246339
02/2001

Echocardiography and pulmonary function testing in childhood onset systemic lupus erythematosus.
Al-Abbad AJ, Cabral DA, Sanatani S, Sandor GG, Seear M, Petty RE, Malleson PN
DOI: 10.1191/096120301669980721
PubMed: 11243507
2001

Hyperbaric oxygen therapy for cerebral palsy: two complications of treatment.
Nuthall G, Seear M, Lepawsky M, Wensley D, Skippen P, Hukin J
DOI: 10.1542/peds.106.6.e80
PubMed: 11099623
12/2000

Hemostatic parameters and platelet activation marker expression in cyanotic and acyanotic pediatric patients undergoing cardiac surgery in the presence of tranexamic acid.
Levin E, Wu J, Devine DV, Alexander J, Reichart C, Sett S, Seear M
PubMed: 10669155
01/2000

Evaluation of a mathematical model to predict intrapulmonary shunt non-invasively.
Seear M, Malagon I, Hui H, Alexander J, Daoust C, Skippen P
DOI: 10.1007/bf03012950
PubMed: 10349930
05/1999

Multiple pulmonary chemodectomas in a child: results of four different therapeutic regimens.
Chow SN, Seear M, Anderson R, Magee F
DOI: 10.1097/00043426-199811000-00021
PubMed: 9856686
1998

Anti-polypeptide immune response mimicking Mycoplasma pneumoniae anti-P1 IgM in idiopathic pulmonary haemosiderosis.
Cimolai N, Seear M
PubMed: 9453387
12/1997

Effect of hyperventilation on regional cerebral blood flow in head-injured children.
Skippen P, Seear M, Poskitt K, Kestle J, Cochrane D, Annich G, Handel J
DOI: 10.1097/00003246-199708000-00031
PubMed: 9267957
08/1997

Chronic cough and wheeze in children: do they all have asthma?
Seear M, Wensley D
DOI: 10.1183/09031936.97.10020342
PubMed: 9042630
02/1997

Bronchial casts in children: a proposed classification based on nine cases and a review of the literature.
Seear M, Hui H, Magee F, Bohn D, Cutz E
DOI: 10.1164/ajrccm.155.1.9001337
PubMed: 9001337
01/1997

The effect of preoperative tranexamic acid on blood loss after cardiac operations in children.
Zonis Z, Seear M, Reichert C, Sett S, Allen C
DOI: 10.1016/s0022-5223(96)70374-4
PubMed: 8622323
05/1996

Mycoplasma pneumoniae as a cofactor in severe respiratory infections.
Cimolai N, Wensley D, Seear M, Thomas ET
PubMed: 8589140
11/1995

Mathematical model of oxygen transport: a teaching aid for normal physiology adaptable to extracorporeal oxygenation circuits.
Seear M, Anderson B, Hall R, Hui H
PubMed: 7598171
06/1995

Functional characteristics of pediatric veno-venous hemofiltration.
Werner HA, Herbertson MJ, Seear MD
PubMed: 8306692
02/1994

Descending aortic blood flow velocity as a noninvasive measure of cardiac output in children.
Seear M, Webber S, Leblanc J
DOI: 10.1007/bf00800672
PubMed: 7991435
1994

Oxygen consumption-oxygen delivery relationship in children.
Seear M, Wensley D, MacNab A
DOI: 10.1016/s0022-3476(05)81690-7
PubMed: 8345415
08/1993

Operating characteristics of pediatric continuous arteriovenous hemofiltration in an animal model.
Werner HA, Herbertson MJ, Seear MD
DOI: 10.1007/bf00864394
PubMed: 8476717
04/1993

Thiamine, riboflavin, and pyridoxine deficiencies in a population of critically ill children.
Seear M, Lockitch G, Jacobson B, Quigley G, MacNab A
DOI: 10.1016/s0022-3476(05)81140-0
PubMed: 1403385
10/1992

Corynebacterium pseudodiphtheriticum pneumonitis in a leukaemic child.
Cimolai N, Rogers P, Seear M
DOI: 10.1136/thx.47.10.838
PubMed: 1481190
10/1992

Doppler-derived mean aortic flow velocity in children: an alternative to cardiac index.
Seear MD, D'Orsogna L, Sandor GG, de Souza E, Popov R
DOI: 10.1007/bf02310565
PubMed: 1946006
10/1991

Pilot study for the development of a monitoring device for ventilated children.
Wensley DF, Noonan P, Seear MD, Werner H, Pirie GE
DOI: 10.1002/ppul.1950110315
PubMed: 1758750
1991

The effect of lung mechanics on gas transport during high-frequency oscillation.
Schindler M, Seear M
DOI: 10.1002/ppul.1950110410
PubMed: 1758758
1991

Comparison of three methods for measuring respiratory mechanics in ventilated children.
Seear M, Wensley D, Werner H
DOI: 10.1002/ppul.1950100412
PubMed: 1896239
1991

Effect of pentoxifylline on hemodynamics, alveolar fluid reabsorption, and pulmonary edema in a model of acute lung injury.
Seear MD, Hannam VL, Kaapa P, Raj JU, O'Brodovich HM
DOI: 10.1164/ajrccm/142.5.1083
PubMed: 2240831
11/1990

Acute aluminum toxicity after continuous intravesical alum irrigation for hemorrhagic cystitis.
Seear MD, Dimmick JE, Rogers PC
DOI: 10.1016/0090-4295(90)80247-k
PubMed: 2219619
10/1990

Amiloride impairs lung water clearance in newborn guinea pigs.
O'Brodovich H, Hannam V, Seear M, Mullen JB
PubMed: 2161411
04/1990

The clinical value and risks of lung biopsy in children with congenital heart disease.
Wilson NJ, Seear MD, Taylor GP, LeBlanc JG, Sandor GG
PubMed: 2106601
03/1990

The effect of desmopressin acetate (DDAVP) on postoperative blood loss after cardiac operations in children.
Seear MD, Wadsworth LD, Rogers PC, Sheps S, Ashmore PG
PubMed: 2666759
08/1989

Two cases of Wernicke's encephalopathy in children: an underdiagnosed complication of poor nutrition.
Seear MD, Norman MG
DOI: 10.1002/ana.410240115
PubMed: 3137859
07/1988

Research

Current Projects
Quality of life for children who need home ventilation and their caregivers. Medical advances over the last 20 years have produced a revolution in child survival. Many of these survivors lead normal lives but a few require some form of assisted ventilation. The trend is to manage these patients in their homes. Numbers have risen steadily to the point that there are now 150 patients registered in the home ventilation clinic from places all over BC. This is now the largest home ventilation clinic in Canada. We are just starting a questionnaire-based study of the quality of life of the affected children and their caregivers. We will also be monitoring extra health-related expenses the family must meet. This is the first study of this kind ever undertaken in children. The results will be a valuable addition to home care planning.

Current Projects
The use of hi-flow nasal oxygen in the treatment of viral bronchiolitis. Bronchiolitis is the single most common cause for admission to pediatric hospitals, including our own. The disease has enormous economic and health consequences. Survivors are frequently left with significant long term health problems including asthma. Despite considerable research, there are no effective therapies other than symptom support. Over this last winter, we conducted a prospective controlled study of the use of hi-flow nasal oxygen in children with bronchiolitis. It was a low-incidence winter so we only managed to enroll 50 patients. Fortunately, we registered our study and it was noticed by staff at Children's Hospital in Sydney, Australia. They now have research clearance to run the same protocol during their bronchiolitis season which starts in June. Hopefully this will allow us to get over 100 patients which will allow us to analyse the data. If numbers are low then we will run the study again in our next winter. This has the potential to improve the care of this common condition so we hope to finish the analysis and submit the work as soon as possible.

Current Projects
Improving the diagnosis of respiratory diseases in children living in low-resource conditions. Each year, over a million children die from lung infections. Accurate diagnosis is a fundamental requirement for the improved treatment protocols needed to reduce this terrible annual mortality. During the last winter we organised a large study involving 5 Indian hospitals. The aim was to define accurate diagnostic criteria to improve the prediction of the major respiratory illnesses affecting children. The organisation worked well. We stopped the study at the end of the viral season in May. At that stage, we had enrolled over 700 patients. The data analysis is not yet complete but clear diagnostic criteria have emerged that will be valuable in advancing the fight against pediatric respiratory deaths.

Grants

$10,000 grant from the BC Children's Hospital Centre for International Child Health (CICH) in 2007. This was partial support for a joint study of drug quality in Chennai, India.

$25,000 grant from the BC Children's Hospital Auxilliary to support general respiratory research.

Research Group Members

Matthew Garayt, Research Assistant