Publications

Recovery of cytomegalovirus DNA from newborn saliva samples by different methods
Journal of Clinical Virology
Oran Goshen, David M. Goldfarb, Laura Book, Peter Tilley, Soren Gantt
DOI: 10.1016/j.jcv.2018.05.001
07/2018

In reference to should infants who fail their newborn hearing screen undergo cytomegalovirus testing ?
The Laryngoscope
Soren Gantt, David M. Goldfarb, Francois Dionne, Dennis Bulman, Sara Menlove Doutré
DOI: 10.1002/lary.27032
07/2018

Effects of spatiotemporal HSV-2 lesion dynamics and antiviral treatment on the risk of HIV-1 acquisition
PLOS Computational Biology
Catherine M. Byrne, Soren Gantt, Daniel Coombs
DOI: 10.1371/journal.pcbi.1006129
04/2018

Diagnosis and management of congenital cytomegalovirus infection
This Changed My Practice
Gantt, Soren and What, I
06/2016

Prospective Characterization of the Risk Factors for Transmission and Symptoms of Primary Human Herpesvirus Infections Among Ugandan Infants
J Infect Dis.
Soren Gantt, Jackson Orem, Elizabeth M. Krantz, Rhoda Ashley Morrow, Stacy Selke, Meei-Li Huang, Joshua T. Schiffer, Keith R. Jerome, Annet Nakaganda, Anna Wald, Corey Casper, Lawrence Corey
DOI: 10.1093/infdis/jiw076
02/2016

Symptomatic Congenital Cytomegalovirus Infection Is Underdiagnosed in British Columbia
The Journal of Pediatrics
Brendan Sorichetti, Oran Goshen, Julie Pauwels, Frederick K. Kozak, Peter Tilley, Mel Krajden, Soren Gantt
DOI: 10.1016/j.jpeds.2015.10.069
02/2016

Patterns of human herpesvirus-8 oral shedding among diverse cohorts of human herpesvirus-8 seropositive persons
Infect Agents Cancer
Rachel A. Bender Ignacio, Jason D. Goldman, Amalia S. Magaret, Stacy Selke, Meei-Li Huang, Soren Gantt, Christine Johnston, Warren T. Phipps, Joshua T. Schiffer, Richard A. Zuckerman, R. Scott McClelland, Connie Celum, Larry Corey, Anna Wald, Corey Casper
DOI: 10.1186/s13027-016-0052-2
02/2016

Risk of congenital cytomegalovirus infection among HIV-exposed uninfected infants is not decreased by maternal nelfinavir use during pregnancyNelfinavir and Congenital CMV Infection
J. Med. Virol.
Soren Gantt, Erin Leister, Denise L. Jacobsen, Isabelle Boucoiran, Meei-Li Huang, Keith R. Jerome, Gonzague Jourdain, Nicole Ngo-Giang-Huong, Sandra Burchett, Lisa Frenkel
DOI: 10.1002/jmv.24420
11/2015

Management of influenza infection in children and pregnant women in BC, an update
382 the Mobile Medical Unit: A unique program in British columbia
Ng, Karen and Paquette, Vanessa and Kang, Kristopher T and Gantt, Soren and Roberts, Ashley
2015

Bacillus Pumilus; A Rare Cause of Paediatric Septic Arthritis. A Case Report
JOURNAL OF RHEUMATOLOGY
Shivamurthy, Vinay and Reilly, Christopher and Gantt, Soren and Guzman, Jaime and Tucker, Lori
2015

Nelfinavir Impairs Glycosylation of Herpes Simplex Virus 1 Envelope Proteins and Blocks Virus Maturation
Advances in Virology
Soren Gantt, Eliora Gachelet, Jacquelyn Carlsson, Serge Barcy, Corey Casper, Michael Lagunoff
DOI: 10.1155/2015/687162
2015

Myeloid Derived Suppressor Cells Are Present at High Frequency in Neonates and Suppress In Vitro T Cell Responses
PLoS ONE
Ana Gervassi, Nicholas Lejarcegui, Sandra Dross, Amanda Jacobson, Grace Itaya, Elvis Kidzeru, Soren Gantt, Heather Jaspan, Helen Horton
DOI: 10.1371/journal.pone.0107816
09/2014

The Role of Myeloid-Derived Suppressor Cells in Immune Ontogeny
Front. Immunol.
Soren Gantt, Ana Gervassi, Heather Jaspan, Helen Horton
DOI: 10.3389/fimmu.2014.00387
08/2014

Reduced human herpesvirus-8 oropharyngeal shedding associated with protease inhibitor-based antiretroviral therapy
Journal of Clinical Virology
Soren Gantt, Ashok Cattamanchi, Elizabeth Krantz, Amalia Magaret, Stacy Selke, Steven R. Kuntz, Meei-Li Huang, Lawrence Corey, Anna Wald, Corey Casper
DOI: 10.1016/j.jcv.2014.03.002
06/2014

Breast milk transmission of nevirapine-resistant HIV-1 to infants after single-dose nevirapine in Beira, Mozambique
Journal of Infectious Diseases
Micek, Mark A and Dross, Sandra and Blanco, Ana Judith and Beck, Ingrid A and Matunha, Laurinda and Seidel, Kristy and Montoya, Pablo and Matediana, Eduardo and Gantt, Soren and Gloyd, Stephen and others
2014

Acute flaccid paralysis in a child infected with enterovirus D68: A case report
BC Medical Journal
Sherwood, Michelle D and Gantt, Soren and Connolly, Mary and Dobson, Simon
2014

Early Life Immunity and Ability to Respond to Vaccines Hindered by Myeloid Derived Suppressor Cells: Implications for Infant HIV Vaccinology
AIDS RESEARCH AND HUMAN RETROVIRUSES
Gervassi, A and Lejarcegui, N and Dross, S and Jacobson, A and Gantt, S and Jaspan, H and Horton, H
2013

The Immunologic Basis for Severe Neonatal Herpes Disease and Potential Strategies for Therapeutic InterventionClinical and Developmental Immunology
Gantt, Soren and Muller, William J.
DOI: 10.1155/2013/369172
2013

Recommended Curriculum for Training in Pediatric Transplant Infectious Diseases
Journal of the Pediatric Infectious Diseases Society
L. Danziger-Isakov, U. Allen, J. Englund, B. Herold, J. Hoffman, M. Green, S. Gantt, D. Kumar, M. G. Michaels, on behalf of the American Society of Transplantation, Pediatric Infectious Diseases Society, and International Pediatric Transplant Association
DOI: 10.1093/jpids/pit079
2013

An artesunate-containing antimalarial treatment regimen did not suppress cytomegalovirus viremiaJournal of Clinical Virology
Gantt, Soren and Huang, Meei-Li and Magaret, Amalia and Bunts, Lisa and Selke, Stacy and Wald, Anna and Rosenthal, Philip J. and Dorsey, Grant and Casper, Corey
DOI: 10.1016/j.jcv.2013.06.008
2013

Human herpesvirus 6, 7 and 8 in solid organ transplantation
American Journal of Transplantation
Le, J and Gantt, Soren
2013

Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and prevention
Gantt, Soren and Casper, Corey and Ambinder, Richard F.
DOI: 10.1097/cco.0b013e328363dfee
2013

Implications of Age-Dependent Immune Responses to Enterovirus 71 Infection for Disease Pathogenesis and Vaccine DesignJournal of the Pediatric Infectious Diseases Society
Gantt, S. and Yao, L. and Kollmann, T. R. and Casper, C. and Zhang, J. and Self, S. G.
DOI: 10.1093/jpids/pit017
2013

Nevirapine-Resistant HIV-1 DNA in Breast Milk After Single-Dose Nevirapine With or Without Zidovudine for Prevention of Mother-to-Child TransmissionJournal of the Pediatric Infectious Diseases Society
Gantt, S. and Payant, R. and Carlsson, J. and Micek, M. A. and Blanco, A. J. and Beck, I. A. and Matunha, L. and Montoya, P. and Matediana, E. and Gloyd, S. and et al.
DOI: 10.1093/jpids/pis065
2012

Effects of Short-Course Zidovudine on the Selection of Nevirapine-Resistant HIV-1 in Women Taking Single-Dose NevirapineJournal of Infectious Diseases
Micek, M. A. and Blanco, A. J. and Carlsson, J. and Beck, I. A. and Dross, S. and Matunha, L. and Seidel, K. and Montoya, P. and Gantt, S. and Matediana, E. and et al.
DOI: 10.1093/infdis/jis282
2012

Central Venous Catheter Repair Is Associated With an Increased Risk of Bacteremia and Central Line-associated Bloodstream Infection in Pediatric Patients
Lundgren, Ingrid S. and Zhou, Chuan and Malone, Frances R. and Mcafee, Nancy G. and Gantt, Soren and Zerr, Danielle M.
DOI: 10.1097/inf.0b013e31823eeec5
2012

Valganciclovir dosing using area under the curve calculations in pediatric solid organ transplant recipients
Pediatr Transplantation
David Villeneuve, Adam Brothers, Eric Harvey, Mariska Kemna, Yuk Law, Thomas Nemeth, Soren Gantt
DOI: 10.1111/petr.12030
2012

Human herpesvirus 8-associated neoplasms: the roles of viral replication and antiviral treatment
Current opinion in infectious diseases
Gantt, Soren and Casper, Corey
2011

the roles of viral replication and antiviral treatmentCurrent Opinion in Infectious Diseases
Gantt, Soren and Casper, Corey
DOI: 10.1097/qco.0b013e3283486d04
2011

The HIV Protease Inhibitor Nelfinavir Inhibits Kaposi's Sarcoma-Associated Herpesvirus Replication In VitroAntimicrobial Agents and Chemotherapy
Gantt, S. and Carlsson, J. and Ikoma, M. and Gachelet, E. and Gray, M. and Geballe, A. P. and Corey, L. and Casper, C. and Lagunoff, M. and Vieira, J.
DOI: 10.1128/aac.01295-10
2011

Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pumpInternational Journal of Antimicrobial Agents
Qin, Xuan and Poon, Brian and Kwong, Justin and Niles, Denver and Schmidt, Byron Z. and Rajagopal, Lakshmi and Gantt, Soren
DOI: 10.1016/j.ijantimicag.2011.03.007
2011

Clinical presentation and outcome of epidemic Kaposi sarcoma in Ugandan childrenInfectious Agents and Cancer
Gantt, Soren and Kakuru, Abel and Wald, Anna and Walusansa, Victoria and Corey, Lawrence and Casper, Corey and Orem, Jackson
DOI: 10.1186/1750-9378-5-s1-a12
2010

Genetic Analyses of HIV-1 env Sequences Demonstrate Limited Compartmentalization in Breast Milk and Suggest Viral Replication within the Breast That Increases with MastitisJournal of Virology
Gantt, S. and Carlsson, J. and Heath, L. and Bull, M. E. and Shetty, A. K. and Mutsvangwa, J. and Musingwini, G. and Woelk, G. and Zijenah, L. S. and Katzenstein, D. A. and et al.
DOI: 10.1128/jvi.00543-10
2010

Outcomes from pandemic influenza A H1N1 infection in recipients of solid-organ transplants: a multicentre cohort studyThe Lancet Infectious Diseases
Kumar, Deepali and Michaels, Marian G and Morris, Michele I and Green, Michael and Avery, Robin K and Liu, Catherine and Danziger-Isakov, Lara and Stosor, Valentina and Estabrook, Michele and Gantt, Soren
DOI: 10.1016/s1473-3099(10)70133-x
2010

Nevirapine Resistance by Timing of HIV Type 1 Infection in Infants Treated with Single-Dose NevirapineClinical Infectious Diseases
Micek, Mark A. and Blanco, Ana Judith and Beck, Ingrid A. and Dross, Sandra and Matunha, Laurinda and Montoya, Pablo and Seidel, Kristy and Gantt, Soren and Matediane, Eduardo and Jamisse, Lilia and et al.
DOI: 10.1086/652151
2010

Intermittent preventive treatment using artemisinin-based combination therapy reduces malaria morbidity among school-aged children in MaliTropical Medicine & International Health
Barger, Breanna and Maiga, Hamma and Traore, Oumar Bila and Tekete, Mamadou and Tembine, Intimbeye and Dara, Antoine and Traore, Zoumana Isaac and Gantt, Soren and Doumbo, Ogobara K. and Djimde, Abdoulaye A.
DOI: 10.1111/j.1365-3156.2009.02294.x
2009

Cytomegalovirus and Epstein-Barr virus in breast milk are associated with HIV-1 shedding but not with mastitis
Gantt, Soren and Carlsson, Jacquelyn and Shetty, Avinash K and Seidel, Kristy D and Qin, Xuan and Mutsvangwa, Junior and Musingwini, Georgina and Woelk, Godfrey and Zijenah, Lynn S and Katzenstein, David A and et al.
DOI: 10.1097/qad.0b013e32830184f2
2008

Laboratory Indicators of Mastitis Are Not Associated with Elevated HIV-1 DNA Loads or Predictive of HIV-1 RNA Loads in Breast MilkThe Journal of Infectious Diseases
DOI: 10.1086/519843
2007

Use of 16S Ribosomal DNA Polymerase Chain Reaction to Identify Haemophilus influenzae Type b as the Etiology of Pericarditis in an Infant
The Pediatric Infectious Disease Journal
Crystal Benson, Soren Gantt, Danielle M Zerr, Xuan Qin, Patrick Abe
DOI: 10.1097/01.inf.0000154593.22356.e2
03/2005

Levels of circumsporozoite protein in the Plasmodium oocyst determine sporozoite morphology
The EMBO journal
2002

Antibodies against Thrombospondin-Related Anonymous Protein Do Not Inhibit Plasmodium Sporozoite Infectivity In VivoInfection and Immunity
Gantt, S. and Persson, C. and Rose, K. and Birkett, A. J. and Abagyan, R. and Nussenzweig, V.
DOI: 10.1128/iai.68.6.3667-3673.2000
2000

Conservation of a Gliding Motility and Cell Invasion Machinery in Apicomplexan Parasites
J Cell Biol
Stefan Kappe, Thomas Bruderer, Soren Gantt, Hisashi Fujioka, Victor Nussenzweig, Robert Ménard
DOI: 10.1083/jcb.147.5.937
11/1999

Proteasome Inhibitors Block Development ofPlasmodium spp.
Antimicrobial agents and chemotherapy
Gantt, Soren M and Myung, Joon Mo and Briones, Marcelo RS and Li, Wei Dong and Corey, EJ and Omura, Satoshi and Nussenzweig, Victor and Sinnis, Photini
1998

Cell Adhesion to a Motif Shared by the Malaria Circumsporozoite Protein and Thrombospondin Is Mediated by Its Glycosaminoglycan-binding Region and Not by CSVTCGJournal of Biological Chemistry
Gantt, S. M.
DOI: 10.1074/jbc.272.31.19205
1997

Research

Current Projects
Infections with human herpesviruses (HHVs), such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), and Kaposi's sarcoma-associated herpesvirus (KSHV), cause an enormous amount of morbidity and mortality worldwide. Although nearly everyone becomes infected with one or more of these viruses, most have no significant illness from them. However, in young infants or people immunocompromised by HIV or having a transplant, these viruses frequently cause a range of severe infections and cancers. Vaccines or drugs to prevent these infections or their complications would have profound public health implications, but first additional research is required to better understand the underlying pathogenesis. As such, we carry out translational research studies, utilizing cohorts of children in Africa and North America as well as epidemiologic, clinical, and molecular approaches, to address fundamental questions about how to prevent and treat HHV-related diseases.

We are particularly interested in the role of HHV infections very early in life. For example, CMV infects approximately 1% of all infants in utero, which frequently results in neurologic sequelae like deafness and mental retardation; postnatal infections, however, are normally benign. Similarly, high risk for Burkitt's lymphoma, one of the most common childhood cancers in Africa, appears to be due to EBV infection in early infancy combined with exposure to malaria. We have established a cohort of children in Uganda who were followed every week during the first year of life to study CMV and EBV infection. The precise timing of infection with these viruses was established by weekly PCR testing. Comprehensive data were collected regarding epidemiologic and biologic risks of acquisition, including detailed behavioral questionnaires, determination of the viral exposure by household contacts, and collection of blood for measurement of virus-specific neutralizing maternal antibodies. Symptoms of illness associated with infection were captured using standardized physical exams and clinical histories, and blood was collected to evaluate the humoral and cellular immune responses to these viruses that are associated with control of viral replication.

Another recent focus of our group has been to elucidate the mechanism of action of the HIV protease inhibitor (PI) nelfinavir to inhibit HHV replication, and investigate the drug's potential to prevent and treat HHV-related diseases. We discovered that nelfinavir is able to block in vitro replication of all HHVs tested to date, at concentrations that are achieved in patients taking doses that are FDA-approved for treatment of HIV. This activity is unique to nelfinavir among PIs, and appears to result from effects of nelfinavir on host cell pathways that are required for viral replication, rather than on the virus itself. Interestingly, at least some of these cellular effects also confer nelfinavir's increasingly appreciated antitumor activities. Because nelfinavir is safe for use in humans, we have undertaken a phase 1/2 trial of nelfinavir for the treatment of Kaposi's sarcoma in Africa and the US. In addition, because nelfinavir is also safe during pregnancy, we are testing whether nelfinavir given to HIV-infected women during pregnancy can prevent congenital CMV infection.

Grants

CIHR Operating Grant - Project: "Correlates of acquisition and immune control of primary Epstein-Barr virus infection in Ugandan infants" – 2014-19

P01 Project: “Immune Control of KSHV Infection and Impact of HIV Infection And Therapy”

NIH (Co-PIs: Soren Gantt and Serge Barcy) 03/01/11 – 02/29/16

Honours & Awards

Sigma Xi Society, 1993

Honors for Undergraduate Research, Brown University, 1993

Rosenbluth Foundation Travel Award, 1999

Research Group Members

Carolyn Smith
Jessica Tuengel
Catherine Byrne
Raidan Alyazidi
Dong Jun Zheng
Aaron Liu, Doctoral Student
Habibur Rahman
Nada Hasan