Overview

The central focus of my research is mental health and addictions, with a particular emphasis on psychosis and the medications used in its treatment. My research program is based on a multidisciplinary and translational approach that spans from "bench to bedside," as I maintain strong and highly productive research programs in both clinical and related preclinical research.

Working in collaboration with some of Canada's finest researchers, I study "psychosis" from three different perspectives. These include idiopathic schizophrenia-spectrum disorders, psychostimulant drug-induced psychosis and (most recently) the post-operative delirium that occurs following cardiac surgery. Despite different etiologies and patient populations, these three conditions share many similarities in terms of symptoms and treatment, and all can be studied in a translational manner.

Publications

Association between serum lipids and antipsychotic response in schizophrenia.
Current neuropharmacology
DOI: 10.2174/1570159x17666190228113348
PubMed: 30819084
02/2019

Diffusion tensor imaging of neurocognitive profiles in a community cohort living in marginal housing.
Brain and behavior
DOI: 10.1002/brb3.1233
PubMed: 30724486
02/2019

The SNAP25 Interactome in Ventromedial Caudate in Schizophrenia Includes the Mitochondrial Protein ARF1.
Neuroscience
DOI: 10.1016/j.neuroscience.2018.12.045
PubMed: 30610939
01/2019

Clozapine-induced obsessive–compulsive symptoms: mechanisms and treatment
Journal of psychiatry & neuroscience : JPN
DOI: 10.1503/jpn.180087
PubMed: 30565908
01/2019

Reduced SNAP25 Protein Fragmentation Contributes to SNARE Complex Dysregulation in Schizophrenia Postmortem Brain.
Neuroscience
DOI: 10.1016/j.neuroscience.2018.12.015
PubMed: 30579835
12/2018

Volumes of the Hippocampal Formation Differentiate Component Processes of Memory in a Community Sample of Homeless and Marginally Housed Persons.
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
Gicas KM and Thornton AE and Waclawik K and Wang N and Jones AA and Panenka WJ and Lang DJ and Smith GN and Vila-Rodriguez F and Leonova O and Barr AM and Procyshyn RM and Buchanan T and Honer WG
DOI: 10.1093/arclin/acy066
PubMed: 30407496
11/2018

The utility of psychotropic drugs on patients with Fetal Alcohol Spectrum Disorder (FASD): a systematic review
DOI: 10.1080/24750573.2018.1458429
10/2018

Antipsychotic prescribing patterns on admission to and at discharge from a tertiary care program for treatment-resistant psychosis
PLOS ONE
Lik Hang N. Lee and Ric M. Procyshyn and Randall F. White and Todd S. Woodward and William G. Honer and Alasdair M. Barr
DOI: 10.1371/journal.pone.0199758
08/2018

Antipsychotic-Associated Symptoms of Tourette Syndrome: A Systematic Review
CNS Drugs
David D. Kim and Alasdair M. Barr and Yunsun Chung and Jessica W. Y. Yuen and Mahyar Etminan and Bruce C. Carleton and Randall F. White and William G. Honer and Ric M. Procyshyn
DOI: 10.1007/s40263-018-0559-8
08/2018

An Intraplantar Hypertonic Saline Assay in Mice for Rapid Screening of Analgesics
Anesthesia & Analgesia
Yahya I. Asiri and Timothy Fung and Stephan K. W. Schwarz and Khalid A. Asseri and Ian D. Welch and Catherine A. Schuppli and Alasdair M. Barr and Richard A. Wall and Ernest Puil and Bernard A. MacLeod
DOI: 10.1213/ane.0000000000002525
08/2018

Repeated Testing With the Hypertonic Saline Assay in Mice for Screening of Analgesic Activity
Anesthesia & Analgesia
Yahya I. Asiri and Timothy Fung and Stephan K. W. Schwarz and Alasdair M. Barr and Ernest Puil and Bernard A. MacLeod
DOI: 10.1213/ane.0000000000003593
07/2018

A systematic review of the effects of CYP2D6 phenotypes on risperidone treatment in children and adolescents.
Child and adolescent psychiatry and mental health
Dodsworth T and Kim DD and Procyshyn RM and Ross CJ and Honer WG and Barr AM
DOI: 10.1186/s13034-018-0243-2
PubMed: 30026806
07/2018

Cognitive deficits in individuals with methamphetamine use disorder: A meta-analysis
Addictive Behaviors
Stéphane Potvin and Julie Pelletier and Stéphanie Grot and Catherine Hébert and Alasdair M. Barr and Tania Lecomte
DOI: 10.1016/j.addbeh.2018.01.021
05/2018

Clozapine-Induced Cardiovascular Side Effects and Autonomic Dysfunction: A Systematic Review
Frontiers in Neuroscience
Jessica W. Y. Yuen and David D. Kim and Ric M. Procyshyn and Randall F. White and William G. Honer and Alasdair M. Barr
DOI: 10.3389/fnins.2018.00203
04/2018

Clinical and functional characteristics of young adults living in single room occupancy housing: preliminary findings from a 10-year longitudinal study.
Canadian journal of public health = Revue canadienne de sante publique
Barbic SP and Jones AA and Woodward M and Piercy M and Mathias S and Vila-Rodriguez F and Leonova O and Smith GN and Buchanan T and Vertinsky AT and Gillingham S and Panenka WJ and Honer WG
DOI: 10.17269/s41997-018-0087-9
PubMed: 29981045
04/2018

Statin add-on therapy for schizophrenia: Is the effect the same for clozapine?
Psychiatry Research
David D. Kim and Alasdair M. Barr and Allen E. Thornton and William G. Honer and Ric M. Procyshyn
DOI: 10.1016/j.psychres.2018.02.039
03/2018

Maternal exercise increases but concurrent maternal fluoxetine prevents the increase in hippocampal neurogenesis of adult offspring.
Psychoneuroendocrinology
Gobinath AR and Wong S and Chow C and Lieblich SE and Barr AM and Galea LAM
DOI: 10.1016/j.psyneuen.2018.02.027
PubMed: 29579632
03/2018

Rapid Change in Fentanyl Prevalence in a Community-Based, High-Risk Sample
JAMA Psychiatry
Andrea A. Jones and Kerry Jang and William J. Panenka and Alasdair M. Barr and G. William MacEwan and Allen E. Thornton and William G. Honer
DOI: 10.1001/jamapsychiatry.2017.4432
03/2018

Exercise-induced hippocampal neurogenesis: 5-HT3 receptor antagonism by antipsychotics as a potential limiting factor in Schizophrenia
Molecular Psychiatry
David D. Kim and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1038/s41380-018-0022-8
02/2018

Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age.
Neurobiology of disease
Ramos-Miguel A and Jones AA and Sawada K and Barr AM and Bayer TA and Falkai P and Leurgans SE and Schneider JA and Bennett DA and Honer WG
DOI: 10.1016/j.nbd.2018.02.006
PubMed: 29496544
02/2018

Effects of physical activity on the symptoms of Tourette syndrome: A systematic review
European Psychiatry
David D. Kim and Darren E.R. Warburton and Nana Wu and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1016/j.eurpsy.2017.11.002
02/2018

Clozapine, elevated heart rate and QTc prolongation
Journal of Psychiatry & Neuroscience
David D. Kim and Randall F. White and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1503/jpn.170135
01/2018

Cannabis and Psychosis A Review of the Links
BC Schizophrenia Society
01/2018

Voluntary running influences the efficacy of fluoxetine in a model of postpartum depression
Neuropharmacology
Aarthi R. Gobinath and Robin J. Richardson and Carmen Chow and Joanna L. Workman and Stephanie E. Lieblich and Alasdair M. Barr and Liisa A.M. Galea
DOI: 10.1016/j.neuropharm.2017.09.017
01/2018

Reversal of Dopamine Supersensitivity as a Mechanism of Action of Clozapine
Psychotherapy and Psychosomatics
David D. Kim and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1159/000491700
2018

Traumatic Brain Injury in a Community-Based Cohort of Homeless and Vulnerably Housed Individuals.
Journal of neurotrauma
Schmitt T and Thornton AE and Rawtaer I and Barr AM and Gicas KM and Lang DJ and Vertinsky AT and Rauscher A and Procyshyn RM and Buchanan T and Cheng A and MacKay S and Leonova O and Panenka WJ
DOI: 10.1089/neu.2017.5076
PubMed: 28741437
09/2017

Exercise-associated extrapyramidal symptoms during treatment with long-acting injectable antipsychotic medications: A case report
Clinical Schizophrenia & Related Psychoses
David D. Kim and Donna J. Lang and Darren E. R. Warburton and Alasdair M. Barr and Randall F. White and William G. Honer and Ric M. Procyshyn
DOI: 10.3371/csrp.dkdl.071317
08/2017

Heart-rate response to alpha2-adrenergic receptor antagonism by antipsychotics.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society
Kim DD and Lang DJ and Warburton DER and Woodward ML and White RF and Barr AM and Honer WG and Procyshyn RM
DOI: 10.1007/s10286-017-0444-4
PubMed: 28674870
07/2017

Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression
Schizophrenia Research
Clare L. Beasley and William G. Honer and Alfredo Ramos-Miguel and Fidel Vila-Rodriguez and Alasdair M. Barr
DOI: 10.1016/j.schres.2017.05.033
06/2017

Effects of Exercise on Serum Triglycerides and Symptoms of Schizophrenia
Journal of Clinical Psychopharmacology
David D. Kim and Donna J. Lang and Darren E.R. Warburton and Alasdair M. Barr and Geoffrey N. Smith and Allen E. Thornton and Randall F. White and William G. Honer and Ric M. Procyshyn
DOI: 10.1097/jcp.0000000000000648
04/2017

SU60. Risk and Protective Factors Associated With Psychotic Symptom Profiles of Marginally Housed Adults.
Schizophrenia bulletin
Jones A and Gicas K and Procyshyn R and Smith G and Vila-Rodriguez F and Leonova O and Langheimer V and Mitchell E and Dhir A and Willi T and Schmitt T and Lang D and Barr A and Honer W
DOI: 10.1093/schbul/sbx024.058
03/2017

Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample.
Molecular neurodegeneration
Ramos-Miguel A and García-Sevilla JA and Barr AM and Bayer TA and Falkai P and Leurgans SE and Schneider JA and Bennett DA and Honer WG and García-Fuster MJ
DOI: 10.1186/s13024-017-0168-x
PubMed: 28320441
03/2017

SA101. Characterization of Presynaptic SNAP-25 Aggregates in Human Postmortem Brain: A Novel Pathologic Index in Schizophrenia?
Schizophrenia bulletin
Ramos-Miguel A and Barr A and Dwork A and Rosoklija G and Mann J and Honer W
DOI: 10.1093/schbul/sbx023.099
03/2017

SU48. A Comparison of Psychotic Symptoms in Subjects With Cocaine or Methamphetamine Dependence vs Schizophrenia Spectrum Disorder.
Schizophrenia bulletin
Alexander P and Gicas K and Willi T and Kim C and Boyeva V and Procyshyn R and Smith G and Thornton A and Panenka W and Jones A and Vila-Rodriguez F and Leonova O and Lang D and MacEwan W and Barr A
DOI: 10.1093/schbul/sbx024.046
03/2017

The Hotel Study—Clinical and Health Service Effectiveness in a Cohort of Homeless or Marginally Housed Persons
The Canadian Journal of Psychiatry
William G. Honer and Alejandro Cervantes-Larios and Andrea A. Jones and Fidel Vila-Rodriguez and Julio S. Montaner and Howard Tran and Jimmy Nham and William J. Panenka and Donna J. Lang and Allen E. Thornton and Talia Vertinsky and Alasdair M. Barr and Ric M. Procyshyn and Geoffrey N. Smith and Tari Buchanan and Mel Krajden and Michael Krausz and G. William MacEwan and Kristina M. Gicas and Olga Leonova and Verena Langheimer and Alexander Rauscher and Krista Schultz
DOI: 10.1177/0706743717693781
02/2017

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence.
Psychopharmacology
Alexander PD and Gicas KM and Willi TS and Kim CN and Boyeva V and Procyshyn RM and Smith GN and Thornton AE and Panenka WJ and Jones AA and Vila-Rodriguez F and Lang DJ and Barr AM
DOI: 10.1007/s00213-017-4551-7
PubMed: 28190084
02/2017

Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?
Neuropsychiatric Disease and Treatment
Fidel Vila-Rodriguez and Donna Lang and Heather Baitz and Kristina Gicas and Allen Thornton and Thomas Ehmann and Geoff N. Smith and Alasdair Barr and Ivan J. Torres and Lili Kopala and G. William MacEwan and Daniel Müller and James Kennedy and William Honer
DOI: 10.2147/ndt.s150488
2017

Proposing the Use of Partial AUC as an Adjunctive Measure in Establishing Bioequivalence Between Deltoid and Gluteal Administration of Long-Acting Injectable Antipsychotics.
European journal of drug metabolism and pharmacokinetics
Lee LH and Choi C and Gershkovich P and Barr AM and Honer WG and Procyshyn RM
DOI: 10.1007/s13318-016-0348-z
PubMed: 27233798
12/2016

Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia
Schizophrenia Research
Vilte E. Barakauskas and Annie Moradian and Alasdair M. Barr and Clare L. Beasley and Gorazd Rosoklija and J. John Mann and Boro Ilievski and Aleksandar Stankov and Andrew J. Dwork and Peter Falkai and Gregg B. Morin and William G. Honer
DOI: 10.1016/j.schres.2016.03.002
11/2016

Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.
Acta neuropathologica
Ramos-Miguel A and Sawada K and Jones AA and Thornton AE and Barr AM and Leurgans SE and Schneider JA and Bennett DA and Honer WG
DOI: 10.1007/s00401-016-1647-9
PubMed: 27866231
11/2016

Structural brain markers are differentially associated with neurocognitive profiles in socially marginalized people with multimorbid illness.
Neuropsychology
Gicas KM and Giesbrecht CJ and Panenka WJ and Lang DJ and Smith GN and Vila-Rodriguez F and Leonova O and Jones AA and Barr AM and Procyshyn RM and Buchanan T and MacEwan GW and Su W and Thornton AE
DOI: 10.1037/neu0000304
PubMed: 27643510
09/2016

Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users.
Schizophrenia research
Willi TS and Lang DJ and Honer WG and Smith GN and Thornton AE and Panenka WJ and Procyshyn RM and Vila-Rodriguez F and Su W and Vertinsky AT and Leonova O and Rauscher A and MacEwan GW and Barr AM
DOI: 10.1016/j.schres.2016.08.001
PubMed: 27499362
08/2016

Elevated clozapine plasma concentration secondary to a urinary tract infection: proposed mechanisms
Journal of Psychiatry & Neuroscience
Lik Hang N. Lee and Randall F. White and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1503/jpn.150156
07/2016

Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence
Psychiatry Research
Taylor S. Willi and William G. Honer and Allen E. Thornton and Kristina Gicas and Ric M. Procyshyn and Fidel Vila-Rodriguez and William J. Panenka and Ana Aleksic and Olga Leonova and Andrea A. Jones and G. William MacEwan and Alasdair M. Barr
DOI: 10.1016/j.psychres.2016.04.059
06/2016

Breakthrough symptoms after switching long-acting injectable paliperidone palmitate from the gluteal to the deltoid site of administration
Journal of Psychiatry & Neuroscience
Ric M. Procyshyn and Jan L. Banasch and Alasdair M. Barr and William G. Honer
DOI: 10.1503/jpn.150206
05/2016

A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene.
Genetic testing and molecular biomarkers
Wang CK and Aleksic A and Xu MS and Procyshyn RM and Ross CJ and Vila-Rodriguez F and Ramos-Miguel A and Yan R and Honer WG and Barr AM
DOI: 10.1089/gtmb.2015.0304
PubMed: 27228319
05/2016

Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users.
Addiction biology
Willi TS and Barr AM and Gicas K and Lang DJ and Vila-Rodriguez F and Su W and Thornton AE and Leonova O and Giesbrecht CJ and Procyshyn RM and Rauscher A and MacEwan WG and Honer WG and Panenka WJ
DOI: 10.1111/adb.12363
PubMed: 26833821
02/2016

Antipsychotic Induced Dopamine Supersensitivity Psychosis: A Comprehensive Review
Current Neuropharmacology
John Yin and Alasdair Barr and Alfredo Ramos-Miguel and Ric Procyshyn
DOI: 10.2174/1570159x14666160606093602
2016

Response to the Letter to the Editor on “Paliperidone Palmitate Long-Acting Injectable Given Intramuscularly in the Deltoid Versus the Gluteal Muscle
Journal of Clinical Psychopharmacology
John Yin and Lik Hang N. Lee and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1097/jcp.0000000000000612
2016

Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample.
Molecular neurodegeneration
Ramos-Miguel A and Hercher C and Beasley CL and Barr AM and Bayer TA and Falkai P and Leurgans SE and Schneider JA and Bennett DA and Honer WG
DOI: 10.1186/s13024-015-0061-4
PubMed: 26628003
12/2015

The Pharmacokinetics of Second-Generation Long-Acting Injectable Antipsychotics: Limitations of Monograph Values.
CNS drugs
Lee LH and Choi C and Collier AC and Barr AM and Honer WG and Procyshyn RM
DOI: 10.1007/s40263-015-0295-2
PubMed: 26585875
12/2015

Increased SNARE Protein-Protein Interactions in Orbitofrontal and Anterior Cingulate Cortices in Schizophrenia
Biological Psychiatry
Alfredo Ramos-Miguel and Clare L. Beasley and Andrew J. Dwork and J. John Mann and Gorazd Rosoklija and Alasdair M. Barr and William G. Honer
DOI: 10.1016/j.biopsych.2014.12.012
09/2015

White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection.
BMC research notes
Tang VM and Lang DJ and Giesbrecht CJ and Panenka WJ and Willi T and Procyshyn RM and Vila-Rodriguez F and Jenkins W and Lecomte T and Boyda HN and Aleksic A and MacEwan GW and Honer WG and Barr AM
DOI: 10.1186/s13104-015-1501-5
PubMed: 26423806
09/2015

Mortality from treatable illnesses in marginally housed adults: a prospective cohort study.
BMJ open
Jones AA and Vila-Rodriguez F and Leonova O and Langheimer V and Lang DJ and Barr AM and Procyshyn RM and Smith GN and Schultz K and Buchanan T and Krausz M and Montaner JS and Honer WG
DOI: 10.1136/bmjopen-2015-008876
PubMed: 26297373
08/2015

Neuroleptic Malignant Syndrome: A Review from a Clinically Oriented Perspective
Current Neuropharmacology
Lurdes Tse and Alasdair Barr and Vanessa Scarapicchia and Fidel Vila-Rodriguez
DOI: 10.2174/1570159x13999150424113345
07/2015

Paliperidone Palmitate Long-Acting Injectable Given Intramuscularly in the Deltoid Versus the Gluteal Muscle
Journal of Clinical Psychopharmacology
John Yin and Abby C. Collier and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1097/jcp.0000000000000361
06/2015

Exercise prevents downregulation of hippocampal presynaptic proteins following olanzapine-elicited metabolic dysregulation in rats: Distinct roles of inhibitory and excitatory terminals.
Neuroscience
Ramos-Miguel A and Honer WG and Boyda HN and Sawada K and Beasley CL and Procyshyn RM and Barr AM
DOI: 10.1016/j.neuroscience.2015.06.022
PubMed: 26086543
06/2015

Development of a cost-efficient novel method for rapid, concurrent genotyping of five common single nucleotide polymorphisms of the brain derived neurotrophic factor (BDNF) gene by tetra-primer amplification refractory mutation system.
International journal of methods in psychiatric research
Wang CK and Xu MS and Ross CJ and Lo R and Procyshyn RM and Vila-Rodriguez F and White RF and Honer WG and Barr AM
DOI: 10.1002/mpr.1475
PubMed: 26118823
06/2015

Therapeutic Drug Levels of Second Generation Antipsychotics in Youth: A Systematic Review
Journal of Child and Adolescent Psychopharmacology
Zachary Whitney and Heidi N. Boyda and Ric M. Procyshyn and Dean Elbe and Tyler Black and Ali Eslami and Alasdair M. Barr
DOI: 10.1089/cap.2014.0044
04/2015

Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum
Neuroscience Letters
Ana C. Andreazza and Vilte E. Barakauskas and Salar Fazeli and Abigail Feresten and Li Shao and Vivien Wei and Che Hsuan Wu and Alasdair M. Barr and Clare L. Beasley
DOI: 10.1016/j.neulet.2015.02.028
03/2015

Response trajectories to clozapine in a secondary analysis of pivotal trials support using treatment response to subtype schizophrenia.
Canadian journal of psychiatry. Revue canadienne de psychiatrie
Honer WG and Jones AA and Thornton AE and Barr AM and Procyshyn RM and Vila-Rodriguez F
PubMed: 25886676
03/2015

Treatment of clozapine-associated weight gain: a systematic review.
European journal of clinical pharmacology
Whitney Z and Procyshyn RM and Fredrikson DH and Barr AM
DOI: 10.1007/s00228-015-1807-1
PubMed: 25627831
01/2015

A case of pseudo-Stauffer's syndrome related to asenapine use
Schizophrenia Research
Krista Schultz and Linda Wang and Alasdair Barr and Fidel Vila Rodriguez
DOI: 10.1016/j.schres.2015.10.015
2015

Incidence of and Risk Factors for Delirium After Cardiac Surgery at a Quaternary Care Center: A Retrospective Cohort Study
Journal of Cardiothoracic and Vascular Anesthesia
Lurdes Tse and Stephan K.W. Schwarz and John B. Bowering and Randell L. Moore and Alasdair M. Barr
DOI: 10.1053/j.jvca.2015.06.018
2015

Spines, Synapses, and Schizophrenia
Biological Psychiatry
Alfredo Ramos-Miguel and Alasdair M. Barr and William G. Honer
DOI: 10.1016/j.biopsych.2015.08.035
2015

Cognition and Plasma Ratio of Clozapine toN-desmethylclozapine in Patients With Clozapine-Resistant Schizophrenia
American Journal of Psychiatry
Allen E. Thornton and Ric M. Procyshyn and Alasdair M. Barr and G. William MacEwan and William G. Honer
DOI: 10.1176/appi.ajp.2015.15070899
2015

Neurocognitive profiles of marginally housed persons with comorbid substance dependence, viral infection, and psychiatric illness.
Journal of clinical and experimental neuropsychology
Gicas KM and Vila-Rodriguez F and Paquet K and Barr AM and Procyshyn RM and Lang DJ and Smith GN and Baitz HA and Giesbrecht CJ and Montaner JS and Krajden M and Krausz M and Thornton AE
DOI: 10.1080/13803395.2014.963519
PubMed: 25380059
11/2014

Postoperative delirium following transcatheter aortic valve implantation: a historical cohort study
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Lurdes Tse and John B. Bowering and Stephan K. W. Schwarz and Randell L. Moore and Kyle D. Burns and Alasdair M. Barr
DOI: 10.1007/s12630-014-0254-2
10/2014

Improving Metabolic and Cardiovascular Health at an Early Psychosis Intervention Program in Vancouver, Canada
Frontiers in Psychiatry
Diane H. Fredrikson and Heidi N. Boyda and Lurdes Tse and Zachary Whitney and Mark A. Pattison and Fred J. Ott and Laura Hansen and Alasdair M. Barr
DOI: 10.3389/fpsyt.2014.00105
09/2014

An Evaluation of the Effects of the Novel Antipsychotic Drug Lurasidone on Glucose Tolerance and Insulin Resistance: A Comparison with Olanzapine
PLoS ONE
Claire Wu and Jessica Yuen and Heidi N. Boyda and Ric M. Procyshyn and Cathy K. Wang and Yahya I. Asiri and Catherine C. Y. Pang and William G. Honer and Alasdair M. Barr
DOI: 10.1371/journal.pone.0107116
09/2014

Cardiovascular effects of acute treatment with the antipsychotic drug olanzapine in rats
Vascular Pharmacology
Joanne Y.T. Leung and Catherine C.Y. Pang and Ric M. Procyshyn and Alasdair M. Barr
DOI: 10.1016/j.vph.2014.06.003
09/2014

Pharmacological treatment of antipsychotic-induced dyslipidemia and hypertension
International Clinical Psychopharmacology
Lurdes Tse and Ric M. Procyshyn and Diane H. Fredrikson and Heidi N. Boyda and William G. Honer and Alasdair M. Barr
DOI: 10.1097/yic.0000000000000014
05/2014

Managing ADHD and disruptive behaviour disorders with combination psychostimulant and antipsychotic treatment
Journal of Psychiatry & Neuroscience
Dean Elbe and Alasdair Barr and William Honer and Ric Procyshyn
DOI: 10.1503/jpn.130288
05/2014

Incidence and risk factors for impaired mobility in older cardiac surgery patients during the early postoperative period
Geriatrics & Gerontology International
Lurdes Tse and John B Bowering and Stephan K W Schwarz and Randell L Moore and Richard Sztramko and Alasdair M Barr
DOI: 10.1111/ggi.12269
03/2014

Clozapine administered once versus twice daily: Does it make a difference?
Medical Hypotheses
Ric M. Procyshyn and Fidel Vila-Rodriguez and William G. Honer and Alasdair M. Barr
DOI: 10.1016/j.mehy.2013.11.043
02/2014

Prevalence and Patterns of Antipsychotic Use in Youth at the Time of Admission and Discharge From an Inpatient Psychiatric Facility
Journal of Clinical Psychopharmacology
Ric M. Procyshyn and Johnny Su and Dean Elbe and Angela Y. Liu and William J. Panenka and Jana Davidson and William G. Honer and Alasdair M. Barr
DOI: 10.1097/jcp.0b013e3182a607dd
02/2014

Antidiabetic-drug combination treatment for glucose intolerance in adult female rats treated acutely with olanzapine
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Heidi N. Boyda and Ric M. Procyshyn and Yahya Asiri and Claire Wu and Cathy K. Wang and Ryan Lo and Catherine C.Y. Pang and William G. Honer and Alasdair M. Barr
DOI: 10.1016/j.pnpbp.2013.10.006
01/2014

The hotel study: multimorbidity in a community sample living in marginal housing.
The American journal of psychiatry
Vila-Rodriguez F and Panenka WJ and Lang DJ and Thornton AE and Vertinsky T and Wong H and Barr AM and Procyshyn RM and Sidhu JJ and Smith GN and Buchanan T and Krajden M and Krausz M and Honer WG
DOI: 10.1176/appi.ajp.2013.12111439
PubMed: 23929175
12/2013

Personalized risk assessment of drug-related harm is associated with health outcomes.
PloS one
Jones AA and Vila-Rodriguez F and Panenka WJ and Leonova O and Strehlau V and Lang DJ and Thornton AE and Wong H and Barr AM and Procyshyn RM and Smith GN and Buchanan T and Krajden M and Honer WG
DOI: 10.1371/journal.pone.0079754
PubMed: 24223192
11/2013

Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness
Schizophrenia Research
Abigail H. Feresten and Vilte Barakauskas and Athena Ypsilanti and Alasdair M. Barr and Clare L. Beasley
DOI: 10.1016/j.schres.2013.07.024
10/2013

Effects of chronic exercise and treatment with the antipsychotic drug olanzapine on hippocampal volume in adult female rats.
Neuroscience
Barr AM and Wu CH and Wong C and Hercher C and Töpfer E and Boyda HN and Procyshyn RM and Honer WG and Beasley CL
DOI: 10.1016/j.neuroscience.2013.10.010
PubMed: 24141179
10/2013

Symptom changes in five dimensions of the Positive and Negative Syndrome Scale in refractory psychosis
European Archives of Psychiatry and Clinical Neuroscience
Todd S. Woodward and Kwanghee Jung and Geoffrey N. Smith and Heungsun Hwang and Alasdair M. Barr and Ric M. Procyshyn and Sean W. Flynn and Mark van der Gaag and William G. Honer
DOI: 10.1007/s00406-013-0460-x
10/2013

A retrospective study of antipsychotic drug switching in a pediatric population
BMC Psychiatry
David Linton and Ric M Procyshyn and Dean Elbe and Lik Hang N Lee and Alasdair M Barr
DOI: 10.1186/1471-244x-13-248
10/2013

Chronic Benign Neutropenia/Agranulocytosis Associated With Non-Clozapine Antipsychotics
American Journal of Psychiatry
Fidel Vila-Rodriguez and Peter Tsang and Alasdair M. Barr
DOI: 10.1176/appi.ajp.2013.13020215
10/2013

Routine exercise ameliorates the metabolic side-effects of treatment with the atypical antipsychotic drug olanzapine in rats.
The international journal of neuropsychopharmacology
Boyda HN and Ramos-Miguel A and Procyshyn RM and Töpfer E and Lant N and Choy HH and Wong R and Li L and Pang CC and Honer WG and Barr AM
DOI: 10.1017/s1461145713000795
PubMed: 23953063
08/2013

Much of late life cognitive decline is not due to common neurodegenerative pathologies
Annals of Neurology
Patricia A. Boyle and Robert S. Wilson and Lei Yu and Alasdair M. Barr and William G. Honer and Julie A. Schneider and David A. Bennett
DOI: 10.1002/ana.23964
07/2013

Management of Medication-Related Cardiometabolic Risk in Patients with Severe Mental Illness
Current Cardiovascular Risk Reports
Donna J. Lang and Alasdair M. Barr and Ric M. Procyshyn
DOI: 10.1007/s12170-013-0321-1
06/2013

Relationships Among Depression, PTSD, Methamphetamine Abuse, and Psychosis
Journal of Dual Diagnosis
Tania Lecomte and Karine Paquin and Kim T. Mueser and G. William MacEwan and Elliot Goldner and Allen E. Thornton and Johann Brink and Donna Lang and Shimi Kang and Alasdair M. Barr and William G. Honer
DOI: 10.1080/15504263.2013.778930
05/2013

Methamphetamine use: A comprehensive review of molecular, preclinical and clinical findings
Drug and Alcohol Dependence
William J. Panenka and Ric M. Procyshyn and Tania Lecomte and G. William MacEwan and Sean W. Flynn and William G. Honer and Alasdair M. Barr
DOI: 10.1016/j.drugalcdep.2012.11.016
05/2013

Antipsychotic and Psychostimulant Drug Combination Therapy in Attention Deficit/Hyperactivity and Disruptive Behavior Disorders: A Systematic Review of Efficacy and Tolerability
Current Psychiatry Reports
David Linton and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1007/s11920-013-0355-6
03/2013

Peripheral adrenoceptors: the impetus behind glucose dysregulation and insulin resistance.
Journal of neuroendocrinology
Boyda HN and Procyshyn RM and Pang CC and Barr AM
DOI: 10.1111/jne.12002
PubMed: 23140239
03/2013

Metabolic Side-Effects of the Novel Second-Generation Antipsychotic Drugs Asenapine and Iloperidone: A Comparison with Olanzapine
PLoS ONE
Heidi N. Boyda and Ric M. Procyshyn and Catherine C. Y. Pang and Erin Hawkes and Daniel Wong and Chen Helen Jin and William G. Honer and Alasdair M. Barr
DOI: 10.1371/journal.pone.0053459
01/2013

Antipsychotic polypharmacy increases metabolic dysregulation in female rats.
Experimental and clinical psychopharmacology
Boyda HN and Procyshyn RM and Tse L and Xu J and Jin CH and Wong D and Pang CC and Honer WG and Barr AM
DOI: 10.1037/a0031228
PubMed: 23356730
01/2013

Methamphetamine-associated psychosis: a new health challenge in Iran
DARU Journal of Pharmaceutical Sciences
Zahra Alam mehrjerdi and Alasdair M Barr and Alireza Noroozi
DOI: 10.1186/2008-2231-21-30
2013

Predictors of Persistent Psychotic Symptoms in Persons With Methamphetamine Abuse Receiving Psychiatric Treatment
The Journal of Nervous and Mental Disease
Tania Lecomte and Kim T. Mueser and William MacEwan and Allen E. Thornton and Tari Buchanan and Vanessa Bouchard and Elliot Goldner and Johann Brink and Donna Lang and Shimi Kang and Alasdair M. Barr and William G. Honer
DOI: 10.1097/nmd.0000000000000059
2013

Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats
Journal of Psychiatry & Neuroscience
Heidi Boyda and Ric Procyshyn and Lurdes Tse and Erin Hawkes and Chen Jin and Catherine Pang and William Honer and Alasdair Barr
DOI: 10.1503/jpn.110140
11/2012

“Differential effects of three classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats”
European Journal of Psychotraumatology
Heidi Noel Boyda and Ric M. Procyshyn and Lurdes Tse and Erin Hawkes and C. Helen Jin and Catherine C.Y. Pang and William G. Honer and Alasdair M. Barr
DOI: 10.3402/ejpt.v3i0.19394
09/2012

Pharmacological risk factors for delirium after cardiac surgery: a review.
Current neuropharmacology
Tse L and Schwarz SK and Bowering JB and Moore RL and Burns KD and Richford CM and Osborn JA and Barr AM
DOI: 10.2174/157015912803217332
PubMed: 23449337
09/2012

Synaptic protein deficits are associated with dementia irrespective of extreme old age
Neurobiology of Aging
Michal Schnaider Beeri and Vahram Haroutunian and James Schmeidler and Mary Sano and Peter Fam and Aaron Kavanaugh and Alasdair M. Barr and William G. Honer and Pavel Katsel
DOI: 10.1016/j.neurobiolaging.2011.08.017
06/2012

Cognitive reserve, presynaptic proteins and dementia in the elderly.
Translational psychiatry
Honer WG and Barr AM and Sawada K and Thornton AE and Morris MC and Leurgans SE and Schneider JA and Bennett DA
DOI: 10.1038/tp.2012.38
PubMed: 22832958
05/2012

Antipsychotic Medications: Linking Receptor Antagonism to Neuropsychological Functioning in First Episode Psychosis
Journal of the International Neuropsychological Society
Heather A. Baitz and Allen E. Thornton and Ric M. Procyshyn and Geoffrey N. Smith and G. William MacEwan and Lili C. Kopala and Alasdair M. Barr and Donna J. Lang and William G. Honer
DOI: 10.1017/s1355617712000343
04/2012

Cardiovascular side-effects of antipsychotic drugs: the role of the autonomic nervous system.
Pharmacology & therapeutics
Leung JY and Barr AM and Procyshyn RM and Honer WG and Pang CC
DOI: 10.1016/j.pharmthera.2012.04.003
PubMed: 22565090
04/2012

Adverse events associated with switching antipsychotics.
Journal of psychiatry & neuroscience : JPN
Su J and Barr AM and Procyshyn RM
DOI: 10.1503/jpn.110096
PubMed: 22182795
01/2012

Co-occurring psychosis, substance related disorders, and viral infection in a socially disadvantaged population
International Clinical Psychopharmacology
Fidel Vila-Rodriguez and G.W. MacEwan and Alasdair Barr and R.M. Procyshyn and Julio Montaner and Donna Lang and A.T. Vertinsky and M. Krajden and Allen Thornton and Geoff Smith and Michael Krausz and William Honer
DOI: 10.1097/01.yic.0000405804.51250.37
09/2011

Excessive Antipsychotic Dosing in a Canadian Outpatient Population
Psychiatric Services
Alasdair M. Barr
DOI: 10.1176/appi.ps.62.6.682-a
06/2011

Excessive Antipsychotic Dosing in a Canadian Outpatient Population
Psychiatric Services
Alasdair M. Barr and William J. Panenka and William G. Honer and Sejal Khara and Ric M. Procyshyn
DOI: 10.1176/ps.62.6.pss6206_0682a
06/2011

Intermittent treatment with olanzapine causes sensitization of the metabolic side-effects in rats.
Neuropharmacology
Boyda HN and Procyshyn RM and Tse L and Wong D and Pang CC and Honer WG and Barr AM
DOI: 10.1016/j.neuropharm.2011.02.019
PubMed: 21376062
03/2011

Long-acting injectable risperidone in treatment refractory patients: A 14-week open-label pilot study
Schizophrenia Research
Ric M. Procyshyn and Alasdair M. Barr and Sean Flynn and Chris Schenk and Soma Ganesan and William G. Honer
DOI: 10.1016/j.schres.2010.07.016
11/2010

Withdrawal
Animal Models of Drug Addiction
Alasdair M. Barr and Heidi N. Boyda and Ric M. Procyshyn
DOI: 10.1007/978-1-60761-934-5_16
10/2010

Preclinical models of antipsychotic drug-induced metabolic side effects
Trends in Pharmacological Sciences
Heidi N. Boyda and Lurdes Tse and Ric M. Procyshyn and William G. Honer and Alasdair M. Barr
DOI: 10.1016/j.tips.2010.07.002
10/2010

A parametric study of the acute effects of antipsychotic drugs on glucose sensitivity in an animal model
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Heidi N. Boyda and Lurdes Tse and Ric M. Procyshyn and Daniel Wong and Tony K.Y. Wu and Cathy C. Pang and Alasdair M. Barr
DOI: 10.1016/j.pnpbp.2010.04.024
08/2010

Medication Errors in Psychiatry
CNS Drugs
Ric M. Procyshyn and Alasdair M. Barr and Tracey Brickell and William G. Honer
DOI: 10.2165/11533710-000000000-00000
07/2010

Prenatal tobacco exposure in first-episode psychosis
Schizophrenia Research
Geoffrey N. Smith and G. William MacEwan and Lili C. Kopala and Thomas S. Ehmann and Kim Good and Allen E. Thornton and Heather Neilson and Donna J. Lang and Alasdair M. Barr and William G. Honer
DOI: 10.1016/j.schres.2010.01.004
06/2010

Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Vilte E. Barakauskas and Athena R. Ypsilanti and Alasdair M. Barr and Sheila M. Innis and William G. Honer and Clare L. Beasley
DOI: 10.1016/j.pnpbp.2010.03.010
05/2010

Anterior internal capsule volumes increase in patients with schizophrenia switched from typical antipsychotics to olanzapine.
Journal of psychopharmacology (Oxford, England)
Goghari VM and Lang DJ and Khorram B and Götz J and Vandorpe RA and Smith GN and Kopala LC and Barr AM and Honer WG
DOI: 10.1177/0269881110363314
PubMed: 20360156
04/2010

Smoking cessation interventions among individuals in methadone maintenance: A brief review
Journal of Substance Abuse Treatment
Chizimuzo T.C. Okoli and Milan Khara and Ric M. Procyshyn and Joy L. Johnson and Alasdair M. Barr and Lorraine Greaves
DOI: 10.1016/j.jsat.2009.10.001
03/2010

Persistent Antipsychotic Polypharmacy and Excessive Dosing in the Community Psychiatric Treatment Setting
The Journal of Clinical Psychiatry
Ric M. Procyshyn and William G. Honer and Tony K. Y. Wu and Rebecca W. Y. Ko and Sean A. McIsaac and Allan H. Young and Joy L. Johnson and Alasdair M. Barr
DOI: 10.4088/jcp.08m04912gre
03/2010

Effect of hypertriglyceridemia on the pharmacokinetics and blood-brain barrier penetration of clozapine and norclozapine following administration to rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Gershkovich P and Sivak O and Sharma A and Barr AM and Procyshyn R and Wasan KM
DOI: 10.1016/j.euroneuro.2010.01.002
PubMed: 20163937
02/2010

A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Barakauskas VE and Beasley CL and Barr AM and Ypsilanti AR and Li HY and Thornton AE and Wong H and Rosokilja G and Mann JJ and Mancevski B and Jakovski Z and Davceva N and Ilievski B and Honer WG
DOI: 10.1038/npp.2009.228
PubMed: 20072114
01/2010

A Comparison of Antipsychotic Drug-Defined Daily Doses Versus Chlorpromazine Equivalent Doses in Patients With or Without Extrapyramidal Motor Symptoms
Journal of Clinical Psychopharmacology
Alasdair M. Barr and William G. Honer and Joy L. Johnson and Tony K.Y. Wu and Ric M. Procyshyn
DOI: 10.1097/jcp.0b013e3181fab7ca
2010

A translational research approach to poor treatment response in patients with schizophrenia: clozapine-antipsychotic polypharmacy.
Journal of psychiatry & neuroscience : JPN
Honer WG and Procyshyn RM and Chen EY and MacEwan GW and Barr AM
PubMed: 19949719
11/2009

Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation
Neurobiology of Learning and Memory
Jefferson W. Kinney and Manuel Sanchez-Alavez and Alasdair M. Barr and Jose R. Criado and Jacqueline N. Crawley and M. Margarita Behrens and Steven J. Henriksen and Tamas Bartfai
DOI: 10.1016/j.nlm.2009.06.005
10/2009

Delirium after cardiac surgery: A retrospective case-control study of incidence and risk factors in a Canadian sample
BC Medical Journal
06/2009

Role of estradiol withdrawal in ‘anhedonic’ sucrose consumption: A model of postpartum depression
Physiology & Behavior
Amanda D. Green and Alasdair M. Barr and Liisa A.M. Galea
DOI: 10.1016/j.physbeh.2009.02.020
05/2009

Cannabis and Psychosis
Visions: BC's Mental Health and Substance Use Journal
05/2009

Do serum lipids predict response to clozapine treatment?
Journal of psychiatry & neuroscience : JPN
Procyshyn RM and Honer WG and Barr AM
PubMed: 19270766
03/2009

Predictors of starting to smoke cigarettes in patients with first episode psychosis.
Schizophrenia research
Smith GN and Wong H and MacEwan GW and Kopala LC and Ehmann TS and Thornton AE and Lang DJ and Barr AM and Procyshyn R and Austin JC and Flynn SW and Honer WG
DOI: 10.1016/j.schres.2008.12.013
PubMed: 19162444
01/2009

SUBSTANCE ABUSE AS A RISK FACTOR FOR FIRST EPISODE PSYCHOSIS
Schizophrenia Research
William Honer and Geoffrey Smith and Hubert Wong and Donna Lang and William Mac Ewan and Lili Kopala and Tom Ehmann and Karen Tee and Ric Procyshyn and Alasdair Barr
DOI: 10.1016/s0920-9964(08)70163-4
06/2008

Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins
European Journal of Neuroscience
Alasdair M. Barr and Kenneth N. Fish and Athina Markou and William G. Honer
DOI: 10.1111/j.1460-9568.2008.06233.x
05/2008

Self-reported motivation to smoke in schizophrenia is related to antipsychotic drug treatment
Schizophrenia Research
Alasdair M. Barr and Ric M. Procyshyn and Philip Hui and Joy L. Johnson and William G. Honer
DOI: 10.1016/j.schres.2007.11.027
03/2008

Altered performance of reelin-receptor ApoER2 deficient mice on spatial tasks using the Barnes maze.
Behavioral neuroscience
Barr AM and MacLaurin SA and Semenova S and Fish KN and Markou A
DOI: 10.1037/0735-7044.121.5.1101
PubMed: 17907841
10/2007

Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment.
Journal of psychiatry & neuroscience : JPN
Procyshyn RM and Wasan KM and Thornton AE and Barr AM and Chen EY and Pomarol-Clotet E and Stip E and Williams R and Macewan GW and Birmingham CL and Honer WG and Clozapine and Risperidone Enhancement Study Group
PubMed: 17823649
09/2007

A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia
Schizophrenia Research
William J. Panenka and Babak Khorram and Alasdair M. Barr and Geoffrey N. Smith and Donna J. Lang and Lili C. Kopala and Robert A. Vandorpe and William G. Honer
DOI: 10.1016/j.schres.2007.05.002
08/2007

Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activity
Journal of Neurochemistry
Matthew N. Hill and Alasdair M. Barr and W.-S. Vanessa Ho and Erica J. Carrier and Boris B. Gorzalka and Cecilia J. Hillard
DOI: 10.1111/j.1471-4159.2007.04688.x
06/2007

The reelin receptors VLDLR and ApoER2 regulate sensorimotor gating in mice
Neuropharmacology
Alasdair M. Barr and Kenneth N. Fish and Athina Markou
DOI: 10.1016/j.neuropharm.2006.11.011
03/2007

Determination of Clozapine and its Metabolite, Norclozapine in Various Biological Matrices Using High-Performance Liquid Chromatography
Drug Development and Industrial Pharmacy
Micheal Rosland and Priscilla Szeto and Ric Procyshyn and Alasdair M. Barr and Kishor M. Wasan
DOI: 10.1080/03639040701484338
01/2007

Conceptual and Methodological Issues??in the Design of Clinical Trials??of Antipsychotics for the Treatment??of Schizophrenia
CNS Drugs
William G Honer and Allen E Thornton and Megan Sherwood and G ??William MacEwan and Tom S Ehmann and Richard Williams and Lili C Kopala and Ric Procyshyn and Alasdair M Barr
DOI: 10.2165/00023210-200721090-00001
2007

Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine.
Molecular psychiatry
Conti B and Maier R and Barr AM and Morale MC and Lu X and Sanna PP and Bilbe G and Hoyer D and Bartfai T
DOI: 10.1038/sj.mp.4001897
PubMed: 17033635
10/2006

Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats
Neuropharmacology
Alasdair M. Barr and Susan B. Powell and Athina Markou and Mark A. Geyer
DOI: 10.1016/j.neuropharm.2006.04.004
09/2006

The need for speed: an update on methamphetamine addiction.
Journal of psychiatry & neuroscience : JPN
Barr AM and Panenka WJ and MacEwan GW and Thornton AE and Lang DJ and Honer WG and Lecomte T
PubMed: 16951733
09/2006

A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests
Neuroscience Letters
Alasdair M. Barr and Jefferson W. Kinney and Matthew N. Hill and Xiaoying Lu and Shannon Biros and Julius Rebek and Tamas Bartfai
DOI: 10.1016/j.neulet.2006.06.033
09/2006

Relevance of Presynaptic Proteins to Neuropsychiatric Disorders
Molecular Mechanisms of Synaptogenesis
DOI: 10.1007/978-0-387-32562-0_27
2006

Prenatal Ethanol Exposure in Rats Decreases Levels of Complexin Proteins in the Frontal Cortex
Alcoholism: Clinical & Experimental Research
Alasdair M. Barr and Candace E. Hofmann and Anthony G. Phillips and Joanne Weinberg and William G. Honer
DOI: 10.1097/01.alc.0000187806.68957.0a
11/2005

Selective effects of typical antipsychotic drugs on SNAP-25 and synaptophysin in the hippocampal trisynaptic pathway
The International Journal of Neuropsychopharmacology
Alasdair M. Barr and Clint E. Young and Anthony G. Phillips and William G. Honer
DOI: 10.1017/s1461145705006000
09/2005

Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity.
Journal of neurochemistry
Conti B and Sugama S and Lucero J and Winsky-Sommerer R and Wirz SA and Maher P and Andrews Z and Barr AM and Morale MC and Paneda C and Pemberton J and Gaidarova S and Behrens MM and Bartfai T
DOI: 10.1111/j.1471-4159.2005.03052.x
PubMed: 15816872
04/2005

Hippocampal Complexin Proteins and Cognitive Dysfunction in Schizophrenia
Archives of General Psychiatry
Ken Sawada and Alasdair M. Barr and Masato Nakamura and Kunimasa Arima and Clint E. Young and Andrew J. Dwork and Peter Falkai and Anthony G. Phillips and William G. Honer
DOI: 10.1001/archpsyc.62.3.263
03/2005

Psychostimulant withdrawal as an inducing condition in animal models of depression
Neuroscience & Biobehavioral Reviews
Alasdair M. Barr and Athina Markou
DOI: 10.1016/j.neubiorev.2005.03.012
01/2005

A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
Proceedings of the National Academy of Sciences of the United States of America
Lu X and Barr AM and Kinney JW and Sanna P and Conti B and Behrens MM and Bartfai T
DOI: 10.1073/pnas.0408891102
PubMed: 15647369
01/2005

Galanin receptors as novel drug targets for the treatment of depression and anxiety
Drug Development Research
Xiaoying Lu and Alasdair M. Barr and Tamas Bartfai
DOI: 10.1002/ddr.20026
2005

Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease
Experimental Neurology
Jeremy M. Van Raamsdonk and Jacqueline Pearson and Daniel A. Rogers and Ge Lu and Vilte E. Barakauskas and Alasdair M. Barr and William G. Honer and Michael R. Hayden and Blair R. Leavitt
DOI: 10.1016/j.expneurol.2005.07.021
2005

Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests.
Proceedings of the National Academy of Sciences of the United States of America
Bartfai T and Lu X and Badie-Mahdavi H and Barr AM and Mazarati A and Hua XY and Yaksh T and Haberhauer G and Ceide SC and Trembleau L and Somogyi L and Kröck L and Rebek J
DOI: 10.1073/pnas.0403802101
PubMed: 15240875
07/2004

Abnormalities of presynaptic protein CDCrel-1 in striatum of rats reared in social isolation: relevance to neural connectivity in schizophrenia.
The European journal of neuroscience
Barr AM and Young CE and Sawada K and Trimble WS and Phillips AG and Honer WG
DOI: 10.1111/j.0953-816x.2004.03457.x
PubMed: 15245502
07/2004

High frequency of TNF alleles -238A and -376A in individuals from northern Sardinia.
Cytokine
Wirz SA and Morale MC and Marchetti B and Barr AM and Sotgiu S and Rosati G and Pugliatti M and Sanna MV and Giliberto O and Bartfai T and Conti B
DOI: 10.1016/j.cyto.2004.02.006
PubMed: 15149631
05/2004

Interleukin-18 null mice show diminished microglial activation and reduced dopaminergic neuron loss following acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment.
Neuroscience
Sugama S and Wirz SA and Barr AM and Conti B and Bartfai T and Shibasaki T
DOI: 10.1016/j.neuroscience.2004.07.020
PubMed: 15350655
01/2004

The Selective Serotonin-2A Receptor Antagonist M100907 Reverses Behavioral Deficits in Dopamine Transporter Knockout Mice
Neuropsychopharmacology
Alasdair M Barr and Virginia Lehmann-Masten and Martin Paulus and Raul R Gainetdinov and Marc G Caron and Mark A Geyer
DOI: 10.1038/sj.npp.1300343
11/2003

Role of Integrin-Linked Kinase in Nerve Growth Factor-Stimulated Neurite Outgrowth
The Journal of Neuroscience
Julia Mills and Murat Digicaylioglu and Arthur T. Legg and Clint E. Young and Sean S. Young and Alasdair M. Barr and Lauren Fletcher and Timothy P. O'Connor and Shoukat Dedhar
DOI: 10.1523/jneurosci.23-05-01638.2003
03/2003

Tolerance to the anhedonic effects of lipopolysaccharide is associated with changes in syntaxin immunoreactivity in the nucleus accumbens.
The international journal of neuropsychopharmacology
Barr AM and Song C and Sawada K and Young CE and Honer WG and Phillips AG
DOI: 10.1017/s146114570200319x
PubMed: 12899733
03/2003

Effects of amisulpride on consummatory negative contrast.
Behavioural pharmacology
Genn RF and Barr AM and Phillips AG
DOI: 10.1097/01.fbp.0000046508.84018.85
PubMed: 12478217
12/2002

High levels of estradiol impair spatial performance in the Morris water maze and increase ‘depressive-like’ behaviors in the female meadow vole
Physiology & Behavior
Liisa A.M Galea and Tiffany T.-Y Lee and Xanthoula Kostaras and Jesse A Sidhu and Alasdair M Barr
DOI: 10.1016/s0031-9384(02)00849-1
11/2002

A ‘crash’ course on psychostimulant withdrawal as a model of depression
Trends in Pharmacological Sciences
Alasdair M Barr and Athina Markou and Anthony G Phillips
DOI: 10.1016/s0165-6147(02)02086-2
10/2002

Exposure to repeated, intermittent d-amphetamine induces sensitization of HPA axis to a subsequent stressor.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Barr AM and Hofmann CE and Weinberg J and Phillips AG
DOI: 10.1016/s0893-133x(01)00308-6
PubMed: 11850143
03/2002

Increased successive negative contrast in rats withdrawn from an escalating-dose schedule of d-amphetamine
Pharmacology Biochemistry and Behavior
Alasdair M. Barr and Anthony G. Phillips
DOI: 10.1016/s0091-3057(01)00664-5
01/2002

Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness.
Molecular psychiatry
Sawada K and Young CE and Barr AM and Longworth K and Takahashi S and Arango V and Mann JJ and Dwork AJ and Falkai P and Phillips AG and Honer WG
DOI: 10.1038/sj.mp.4000978
PubMed: 12082566
01/2002

Repeated electroconvulsive shock attenuates the depressive-like effects of d-amphetamine withdrawal on brain reward function in rats
Psychopharmacology
Alasdair M. Barr and Athanasios P. Zis and Anthony G. Phillips
DOI: 10.1007/s002130100906
09/2001

Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression
Behavioural Brain Research
Liisa A.M Galea and Jennifer K Wide and Alasdair M Barr
DOI: 10.1016/s0166-4328(01)00170-x
07/2001

Paradoxical effects of chronic corticosterone on forced swim behaviours in aged male and female rats
European Journal of Pharmacology
Lori A Brotto and Boris B Gorzalka and Alasdair M Barr
DOI: 10.1016/s0014-2999(01)01148-7
07/2001

Chronic corticosterone enhances the rewarding effect of hypothalamic self-stimulation in rats
Brain Research
Alasdair M Barr and Lori A Brotto and Anthony G Phillips
DOI: 10.1016/s0006-8993(00)02652-4
09/2000

Sex differences in forced-swim and open-field test behaviours after chronic administration of melatonin
European Journal of Pharmacology
Lori A Brotto and Alasdair M Barr and Boris B Gorzalka
DOI: 10.1016/s0014-2999(00)00491-x
08/2000

Effects of Withdrawal from an Escalating Dose Schedule of d-Amphetamine on Sexual Behavior in the Male Rat
Pharmacology Biochemistry and Behavior
Alasdair M Barr and Dennis F Fiorino and Anthony G Phillips
DOI: 10.1016/s0091-3057(99)00156-2
11/1999

Withdrawal following repeated exposure to d-amphetamine decreases responding for a sucrose solution as measured by a progressive ratio schedule of reinforcement.
Psychopharmacology
Barr AM and Phillips AG
DOI: 10.1007/s002130050812
PubMed: 9952071
01/1999

Chronic mild stress has no effect on responding by rats for sucrose under a progressive ratio schedule
Physiology & Behavior
Alasdair M Barr and Anthony G Phillips
DOI: 10.1016/s0031-9384(98)00060-2
07/1998

Stimulation of the Ventral Subiculum of the Hippocampus Evokes Glutamate Receptor-mediated Changes in Dopamine Efflux in the Rat Nucleus Accumbens
European Journal of Neuroscience
Charles D. Blaha and Charles R. Yang and Stan B. Floresco and Alasdair M. Barr and Anthony G. Phillips
DOI: 10.1111/j.1460-9568.1997.tb01441.x
05/1997

Effects of chronic mild stress on motivation for sucrose: mixed messages
Psychopharmacology
A. G. Phillips and Alasdair M. Barr
DOI: 10.1007/s002130050469
1997

Research
Research Group Members

Jehan Alamri
Leo Huang, Directed Studies Student
David Kim, Doctoral Student
Nicholas Lee, Research Assistant
Lulu Lian, Research Assistant
Su Lin Lim, Research Assistant
Zainab Mizban, Masters Student
Kiki Yu, Undergraduate Student, Undergraduate Student
Jessica Yuen, PhD Student