Overview

The central focus of my research is mental health and addictions, with a particular emphasis on psychosis and the medications used in its treatment. My research program is based on a multidisciplinary and translational approach that spans from "bench to bedside," as I maintain strong and highly productive research programs in both clinical and related preclinical research.

Working in collaboration with some of Canada's finest researchers, I study "psychosis" from three different perspectives. These include idiopathic schizophrenia-spectrum disorders, psychostimulant drug-induced psychosis and (most recently) the post-operative delirium that occurs following cardiac surgery. Despite different etiologies and patient populations, these three conditions share many similarities in terms of symptoms and treatment, and all can be studied in a translational manner.

Publications

Antipsychotic prescribing patterns on admission to and at discharge from a tertiary care program for treatment-resistant psychosis
PLOS ONE
Lik Hang N. Lee and Ric M. Procyshyn and Randall F. White and Todd S. Woodward and William G. Honer and Alasdair M. Barr
DOI: 10.1371/journal.pone.0199758
08/2018

Antipsychotic-Associated Symptoms of Tourette Syndrome: A Systematic Review
CNS Drugs
David D. Kim and Alasdair M. Barr and Yunsun Chung and Jessica W. Y. Yuen and Mahyar Etminan and Bruce C. Carleton and Randall F. White and William G. Honer and Ric M. Procyshyn
DOI: 10.1007/s40263-018-0559-8
08/2018

An Intraplantar Hypertonic Saline Assay in Mice for Rapid Screening of Analgesics
Anesthesia & Analgesia
Yahya I. Asiri and Timothy Fung and Stephan K. W. Schwarz and Khalid A. Asseri and Ian D. Welch and Catherine A. Schuppli and Alasdair M. Barr and Richard A. Wall and Ernest Puil and Bernard A. MacLeod
DOI: 10.1213/ane.0000000000002525
08/2018

Repeated Testing With the Hypertonic Saline Assay in Mice for Screening of Analgesic Activity
Anesthesia & Analgesia
Yahya I. Asiri and Timothy Fung and Stephan K. W. Schwarz and Alasdair M. Barr and Ernest Puil and Bernard A. MacLeod
DOI: 10.1213/ane.0000000000003593
07/2018

Cognitive deficits in individuals with methamphetamine use disorder: A meta-analysis
Addictive Behaviors
Stéphane Potvin and Julie Pelletier and Stéphanie Grot and Catherine Hébert and Alasdair M. Barr and Tania Lecomte
DOI: 10.1016/j.addbeh.2018.01.021
05/2018

Clozapine-Induced Cardiovascular Side Effects and Autonomic Dysfunction: A Systematic Review
Frontiers in Neuroscience
Jessica W. Y. Yuen and David D. Kim and Ric M. Procyshyn and Randall F. White and William G. Honer and Alasdair M. Barr
DOI: 10.3389/fnins.2018.00203
04/2018

Statin add-on therapy for schizophrenia: Is the effect the same for clozapine?
Psychiatry Research
David D. Kim and Alasdair M. Barr and Allen E. Thornton and William G. Honer and Ric M. Procyshyn
DOI: 10.1016/j.psychres.2018.02.039
03/2018

Rapid Change in Fentanyl Prevalence in a Community-Based, High-Risk Sample
JAMA Psychiatry
Andrea A. Jones and Kerry Jang and William J. Panenka and Alasdair M. Barr and G. William MacEwan and Allen E. Thornton and William G. Honer
DOI: 10.1001/jamapsychiatry.2017.4432
03/2018

Exercise-induced hippocampal neurogenesis: 5-HT3 receptor antagonism by antipsychotics as a potential limiting factor in Schizophrenia
Molecular Psychiatry
David D. Kim and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1038/s41380-018-0022-8
02/2018

Effects of physical activity on the symptoms of Tourette syndrome: A systematic review
European Psychiatry
David D. Kim and Darren E.R. Warburton and Nana Wu and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1016/j.eurpsy.2017.11.002
02/2018

Clozapine, elevated heart rate and QTc prolongation
Journal of Psychiatry & Neuroscience
David D. Kim and Randall F. White and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1503/jpn.170135
01/2018

Voluntary running influences the efficacy of fluoxetine in a model of postpartum depression
Neuropharmacology
Aarthi R. Gobinath and Robin J. Richardson and Carmen Chow and Joanna L. Workman and Stephanie E. Lieblich and Alasdair M. Barr and Liisa A.M. Galea
DOI: 10.1016/j.neuropharm.2017.09.017
01/2018

Reversal of Dopamine Supersensitivity as a Mechanism of Action of Clozapine
Psychotherapy and Psychosomatics
David D. Kim and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1159/000491700
2018

Exercise-associated extrapyramidal symptoms during treatment with long-acting injectable antipsychotic medications: A case report
Clinical Schizophrenia & Related Psychoses
David D. Kim and Donna J. Lang and Darren E. R. Warburton and Alasdair M. Barr and Randall F. White and William G. Honer and Ric M. Procyshyn
DOI: 10.3371/csrp.dkdl.071317
08/2017

Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression
Schizophrenia Research
Clare L. Beasley and William G. Honer and Alfredo Ramos-Miguel and Fidel Vila-Rodriguez and Alasdair M. Barr
DOI: 10.1016/j.schres.2017.05.033
06/2017

Effects of Exercise on Serum Triglycerides and Symptoms of Schizophrenia
Journal of Clinical Psychopharmacology
David D. Kim and Donna J. Lang and Darren E.R. Warburton and Alasdair M. Barr and Geoffrey N. Smith and Allen E. Thornton and Randall F. White and William G. Honer and Ric M. Procyshyn
DOI: 10.1097/jcp.0000000000000648
04/2017

The Hotel Study—Clinical and Health Service Effectiveness in a Cohort of Homeless or Marginally Housed Persons
The Canadian Journal of Psychiatry
William G. Honer and Alejandro Cervantes-Larios and Andrea A. Jones and Fidel Vila-Rodriguez and Julio S. Montaner and Howard Tran and Jimmy Nham and William J. Panenka and Donna J. Lang and Allen E. Thornton and Talia Vertinsky and Alasdair M. Barr and Ric M. Procyshyn and Geoffrey N. Smith and Tari Buchanan and Mel Krajden and Michael Krausz and G. William MacEwan and Kristina M. Gicas and Olga Leonova and Verena Langheimer and Alexander Rauscher and Krista Schultz
DOI: 10.1177/0706743717693781
02/2017

Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?
Neuropsychiatric Disease and Treatment
Fidel Vila-Rodriguez and Donna Lang and Heather Baitz and Kristina Gicas and Allen Thornton and Thomas Ehmann and Geoff N. Smith and Alasdair Barr and Ivan J. Torres and Lili Kopala and G. William MacEwan and Daniel Müller and James Kennedy and William Honer
DOI: 10.2147/ndt.s150488
2017

Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia
Schizophrenia Research
Vilte E. Barakauskas and Annie Moradian and Alasdair M. Barr and Clare L. Beasley and Gorazd Rosoklija and J. John Mann and Boro Ilievski and Aleksandar Stankov and Andrew J. Dwork and Peter Falkai and Gregg B. Morin and William G. Honer
DOI: 10.1016/j.schres.2016.03.002
11/2016

Elevated clozapine plasma concentration secondary to a urinary tract infection: proposed mechanisms
Journal of Psychiatry & Neuroscience
Lik Hang N. Lee and Randall F. White and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1503/jpn.150156
07/2016

Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence
Psychiatry Research
Taylor S. Willi and William G. Honer and Allen E. Thornton and Kristina Gicas and Ric M. Procyshyn and Fidel Vila-Rodriguez and William J. Panenka and Ana Aleksic and Olga Leonova and Andrea A. Jones and G. William MacEwan and Alasdair M. Barr
DOI: 10.1016/j.psychres.2016.04.059
06/2016

Breakthrough symptoms after switching long-acting injectable paliperidone palmitate from the gluteal to the deltoid site of administration
Journal of Psychiatry & Neuroscience
Ric M. Procyshyn and Jan L. Banasch and Alasdair M. Barr and William G. Honer
DOI: 10.1503/jpn.150206
05/2016

Antipsychotic Induced Dopamine Supersensitivity Psychosis: A Comprehensive Review
Current Neuropharmacology
John Yin and Alasdair Barr and Alfredo Ramos-Miguel and Ric Procyshyn
DOI: 10.2174/1570159x14666160606093602
2016

Response to the Letter to the Editor on “Paliperidone Palmitate Long-Acting Injectable Given Intramuscularly in the Deltoid Versus the Gluteal Muscle
Journal of Clinical Psychopharmacology
John Yin and Lik Hang N. Lee and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1097/jcp.0000000000000612
2016

Increased SNARE Protein-Protein Interactions in Orbitofrontal and Anterior Cingulate Cortices in Schizophrenia
Biological Psychiatry
Alfredo Ramos-Miguel and Clare L. Beasley and Andrew J. Dwork and J. John Mann and Gorazd Rosoklija and Alasdair M. Barr and William G. Honer
DOI: 10.1016/j.biopsych.2014.12.012
09/2015

Neuroleptic Malignant Syndrome: A Review from a Clinically Oriented Perspective
Current Neuropharmacology
Lurdes Tse and Alasdair Barr and Vanessa Scarapicchia and Fidel Vila-Rodriguez
DOI: 10.2174/1570159x13999150424113345
07/2015

Paliperidone Palmitate Long-Acting Injectable Given Intramuscularly in the Deltoid Versus the Gluteal Muscle
Journal of Clinical Psychopharmacology
John Yin and Abby C. Collier and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1097/jcp.0000000000000361
06/2015

Therapeutic Drug Levels of Second Generation Antipsychotics in Youth: A Systematic Review
Journal of Child and Adolescent Psychopharmacology
Zachary Whitney and Heidi N. Boyda and Ric M. Procyshyn and Dean Elbe and Tyler Black and Ali Eslami and Alasdair M. Barr
DOI: 10.1089/cap.2014.0044
04/2015

Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum
Neuroscience Letters
Ana C. Andreazza and Vilte E. Barakauskas and Salar Fazeli and Abigail Feresten and Li Shao and Vivien Wei and Che Hsuan Wu and Alasdair M. Barr and Clare L. Beasley
DOI: 10.1016/j.neulet.2015.02.028
03/2015

A case of pseudo-Stauffer's syndrome related to asenapine use
Schizophrenia Research
Krista Schultz and Linda Wang and Alasdair Barr and Fidel Vila Rodriguez
DOI: 10.1016/j.schres.2015.10.015
2015

Incidence of and Risk Factors for Delirium After Cardiac Surgery at a Quaternary Care Center: A Retrospective Cohort Study
Journal of Cardiothoracic and Vascular Anesthesia
Lurdes Tse and Stephan K.W. Schwarz and John B. Bowering and Randell L. Moore and Alasdair M. Barr
DOI: 10.1053/j.jvca.2015.06.018
2015

Spines, Synapses, and Schizophrenia
Biological Psychiatry
Alfredo Ramos-Miguel and Alasdair M. Barr and William G. Honer
DOI: 10.1016/j.biopsych.2015.08.035
2015

Cognition and Plasma Ratio of Clozapine toN-desmethylclozapine in Patients With Clozapine-Resistant Schizophrenia
American Journal of Psychiatry
Allen E. Thornton and Ric M. Procyshyn and Alasdair M. Barr and G. William MacEwan and William G. Honer
DOI: 10.1176/appi.ajp.2015.15070899
2015

Postoperative delirium following transcatheter aortic valve implantation: a historical cohort study
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Lurdes Tse and John B. Bowering and Stephan K. W. Schwarz and Randell L. Moore and Kyle D. Burns and Alasdair M. Barr
DOI: 10.1007/s12630-014-0254-2
10/2014

Improving Metabolic and Cardiovascular Health at an Early Psychosis Intervention Program in Vancouver, Canada
Frontiers in Psychiatry
Diane H. Fredrikson and Heidi N. Boyda and Lurdes Tse and Zachary Whitney and Mark A. Pattison and Fred J. Ott and Laura Hansen and Alasdair M. Barr
DOI: 10.3389/fpsyt.2014.00105
09/2014

An Evaluation of the Effects of the Novel Antipsychotic Drug Lurasidone on Glucose Tolerance and Insulin Resistance: A Comparison with Olanzapine
PLoS ONE
Claire Wu and Jessica Yuen and Heidi N. Boyda and Ric M. Procyshyn and Cathy K. Wang and Yahya I. Asiri and Catherine C. Y. Pang and William G. Honer and Alasdair M. Barr
DOI: 10.1371/journal.pone.0107116
09/2014

Cardiovascular effects of acute treatment with the antipsychotic drug olanzapine in rats
Vascular Pharmacology
Joanne Y.T. Leung and Catherine C.Y. Pang and Ric M. Procyshyn and Alasdair M. Barr
DOI: 10.1016/j.vph.2014.06.003
09/2014

Pharmacological treatment of antipsychotic-induced dyslipidemia and hypertension
International Clinical Psychopharmacology
Lurdes Tse and Ric M. Procyshyn and Diane H. Fredrikson and Heidi N. Boyda and William G. Honer and Alasdair M. Barr
DOI: 10.1097/yic.0000000000000014
05/2014

Managing ADHD and disruptive behaviour disorders with combination psychostimulant and antipsychotic treatment
Journal of Psychiatry & Neuroscience
Dean Elbe and Alasdair Barr and William Honer and Ric Procyshyn
DOI: 10.1503/jpn.130288
05/2014

Incidence and risk factors for impaired mobility in older cardiac surgery patients during the early postoperative period
Geriatrics & Gerontology International
Lurdes Tse and John B Bowering and Stephan K W Schwarz and Randell L Moore and Richard Sztramko and Alasdair M Barr
DOI: 10.1111/ggi.12269
03/2014

Clozapine administered once versus twice daily: Does it make a difference?
Medical Hypotheses
Ric M. Procyshyn and Fidel Vila-Rodriguez and William G. Honer and Alasdair M. Barr
DOI: 10.1016/j.mehy.2013.11.043
02/2014

Prevalence and Patterns of Antipsychotic Use in Youth at the Time of Admission and Discharge From an Inpatient Psychiatric Facility
Journal of Clinical Psychopharmacology
Ric M. Procyshyn and Johnny Su and Dean Elbe and Angela Y. Liu and William J. Panenka and Jana Davidson and William G. Honer and Alasdair M. Barr
DOI: 10.1097/jcp.0b013e3182a607dd
02/2014

Antidiabetic-drug combination treatment for glucose intolerance in adult female rats treated acutely with olanzapine
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Heidi N. Boyda and Ric M. Procyshyn and Yahya Asiri and Claire Wu and Cathy K. Wang and Ryan Lo and Catherine C.Y. Pang and William G. Honer and Alasdair M. Barr
DOI: 10.1016/j.pnpbp.2013.10.006
01/2014

Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness
Schizophrenia Research
Abigail H. Feresten and Vilte Barakauskas and Athena Ypsilanti and Alasdair M. Barr and Clare L. Beasley
DOI: 10.1016/j.schres.2013.07.024
10/2013

Symptom changes in five dimensions of the Positive and Negative Syndrome Scale in refractory psychosis
European Archives of Psychiatry and Clinical Neuroscience
Todd S. Woodward and Kwanghee Jung and Geoffrey N. Smith and Heungsun Hwang and Alasdair M. Barr and Ric M. Procyshyn and Sean W. Flynn and Mark van der Gaag and William G. Honer
DOI: 10.1007/s00406-013-0460-x
10/2013

A retrospective study of antipsychotic drug switching in a pediatric population
BMC Psychiatry
David Linton and Ric M Procyshyn and Dean Elbe and Lik Hang N Lee and Alasdair M Barr
DOI: 10.1186/1471-244x-13-248
10/2013

Chronic Benign Neutropenia/Agranulocytosis Associated With Non-Clozapine Antipsychotics
American Journal of Psychiatry
Fidel Vila-Rodriguez and Peter Tsang and Alasdair M. Barr
DOI: 10.1176/appi.ajp.2013.13020215
10/2013

Much of late life cognitive decline is not due to common neurodegenerative pathologies
Annals of Neurology
Patricia A. Boyle and Robert S. Wilson and Lei Yu and Alasdair M. Barr and William G. Honer and Julie A. Schneider and David A. Bennett
DOI: 10.1002/ana.23964
07/2013

Management of Medication-Related Cardiometabolic Risk in Patients with Severe Mental Illness
Current Cardiovascular Risk Reports
Donna J. Lang and Alasdair M. Barr and Ric M. Procyshyn
DOI: 10.1007/s12170-013-0321-1
06/2013

Relationships Among Depression, PTSD, Methamphetamine Abuse, and Psychosis
Journal of Dual Diagnosis
Tania Lecomte and Karine Paquin and Kim T. Mueser and G. William MacEwan and Elliot Goldner and Allen E. Thornton and Johann Brink and Donna Lang and Shimi Kang and Alasdair M. Barr and William G. Honer
DOI: 10.1080/15504263.2013.778930
05/2013

Methamphetamine use: A comprehensive review of molecular, preclinical and clinical findings
Drug and Alcohol Dependence
William J. Panenka and Ric M. Procyshyn and Tania Lecomte and G. William MacEwan and Sean W. Flynn and William G. Honer and Alasdair M. Barr
DOI: 10.1016/j.drugalcdep.2012.11.016
05/2013

Antipsychotic and Psychostimulant Drug Combination Therapy in Attention Deficit/Hyperactivity and Disruptive Behavior Disorders: A Systematic Review of Efficacy and Tolerability
Current Psychiatry Reports
David Linton and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1007/s11920-013-0355-6
03/2013

Metabolic Side-Effects of the Novel Second-Generation Antipsychotic Drugs Asenapine and Iloperidone: A Comparison with Olanzapine
PLoS ONE
Heidi N. Boyda and Ric M. Procyshyn and Catherine C. Y. Pang and Erin Hawkes and Daniel Wong and Chen Helen Jin and William G. Honer and Alasdair M. Barr
DOI: 10.1371/journal.pone.0053459
01/2013

Methamphetamine-associated psychosis: a new health challenge in Iran
DARU Journal of Pharmaceutical Sciences
Zahra Alam mehrjerdi and Alasdair M Barr and Alireza Noroozi
DOI: 10.1186/2008-2231-21-30
2013

Predictors of Persistent Psychotic Symptoms in Persons With Methamphetamine Abuse Receiving Psychiatric Treatment
The Journal of Nervous and Mental Disease
Tania Lecomte and Kim T. Mueser and William MacEwan and Allen E. Thornton and Tari Buchanan and Vanessa Bouchard and Elliot Goldner and Johann Brink and Donna Lang and Shimi Kang and Alasdair M. Barr and William G. Honer
DOI: 10.1097/nmd.0000000000000059
2013

Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats
Journal of Psychiatry & Neuroscience
Heidi Boyda and Ric Procyshyn and Lurdes Tse and Erin Hawkes and Chen Jin and Catherine Pang and William Honer and Alasdair Barr
DOI: 10.1503/jpn.110140
11/2012

“Differential effects of three classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats”
European Journal of Psychotraumatology
Heidi Noel Boyda and Ric M. Procyshyn and Lurdes Tse and Erin Hawkes and C. Helen Jin and Catherine C.Y. Pang and William G. Honer and Alasdair M. Barr
DOI: 10.3402/ejpt.v3i0.19394
09/2012

Synaptic protein deficits are associated with dementia irrespective of extreme old age
Neurobiology of Aging
Michal Schnaider Beeri and Vahram Haroutunian and James Schmeidler and Mary Sano and Peter Fam and Aaron Kavanaugh and Alasdair M. Barr and William G. Honer and Pavel Katsel
DOI: 10.1016/j.neurobiolaging.2011.08.017
06/2012

Antipsychotic Medications: Linking Receptor Antagonism to Neuropsychological Functioning in First Episode Psychosis
Journal of the International Neuropsychological Society
Heather A. Baitz and Allen E. Thornton and Ric M. Procyshyn and Geoffrey N. Smith and G. William MacEwan and Lili C. Kopala and Alasdair M. Barr and Donna J. Lang and William G. Honer
DOI: 10.1017/s1355617712000343
04/2012

Co-occurring psychosis, substance related disorders, and viral infection in a socially disadvantaged population
International Clinical Psychopharmacology
Fidel Vila-Rodriguez and G.W. MacEwan and Alasdair Barr and R.M. Procyshyn and Julio Montaner and Donna Lang and A.T. Vertinsky and M. Krajden and Allen Thornton and Geoff Smith and Michael Krausz and William Honer
DOI: 10.1097/01.yic.0000405804.51250.37
09/2011

Excessive Antipsychotic Dosing in a Canadian Outpatient Population
Psychiatric Services
Alasdair M. Barr
DOI: 10.1176/appi.ps.62.6.682-a
06/2011

Excessive Antipsychotic Dosing in a Canadian Outpatient Population
Psychiatric Services
Alasdair M. Barr and William J. Panenka and William G. Honer and Sejal Khara and Ric M. Procyshyn
DOI: 10.1176/ps.62.6.pss6206_0682a
06/2011

Long-acting injectable risperidone in treatment refractory patients: A 14-week open-label pilot study
Schizophrenia Research
Ric M. Procyshyn and Alasdair M. Barr and Sean Flynn and Chris Schenk and Soma Ganesan and William G. Honer
DOI: 10.1016/j.schres.2010.07.016
11/2010

Withdrawal
Animal Models of Drug Addiction
Alasdair M. Barr and Heidi N. Boyda and Ric M. Procyshyn
DOI: 10.1007/978-1-60761-934-5_16
10/2010

Preclinical models of antipsychotic drug-induced metabolic side effects
Trends in Pharmacological Sciences
Heidi N. Boyda and Lurdes Tse and Ric M. Procyshyn and William G. Honer and Alasdair M. Barr
DOI: 10.1016/j.tips.2010.07.002
10/2010

A parametric study of the acute effects of antipsychotic drugs on glucose sensitivity in an animal model
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Heidi N. Boyda and Lurdes Tse and Ric M. Procyshyn and Daniel Wong and Tony K.Y. Wu and Cathy C. Pang and Alasdair M. Barr
DOI: 10.1016/j.pnpbp.2010.04.024
08/2010

Medication Errors in Psychiatry
CNS Drugs
Ric M. Procyshyn and Alasdair M. Barr and Tracey Brickell and William G. Honer
DOI: 10.2165/11533710-000000000-00000
07/2010

Prenatal tobacco exposure in first-episode psychosis
Schizophrenia Research
Geoffrey N. Smith and G. William MacEwan and Lili C. Kopala and Thomas S. Ehmann and Kim Good and Allen E. Thornton and Heather Neilson and Donna J. Lang and Alasdair M. Barr and William G. Honer
DOI: 10.1016/j.schres.2010.01.004
06/2010

Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Vilte E. Barakauskas and Athena R. Ypsilanti and Alasdair M. Barr and Sheila M. Innis and William G. Honer and Clare L. Beasley
DOI: 10.1016/j.pnpbp.2010.03.010
05/2010

Smoking cessation interventions among individuals in methadone maintenance: A brief review
Journal of Substance Abuse Treatment
Chizimuzo T.C. Okoli and Milan Khara and Ric M. Procyshyn and Joy L. Johnson and Alasdair M. Barr and Lorraine Greaves
DOI: 10.1016/j.jsat.2009.10.001
03/2010

Persistent Antipsychotic Polypharmacy and Excessive Dosing in the Community Psychiatric Treatment Setting
The Journal of Clinical Psychiatry
Ric M. Procyshyn and William G. Honer and Tony K. Y. Wu and Rebecca W. Y. Ko and Sean A. McIsaac and Allan H. Young and Joy L. Johnson and Alasdair M. Barr
DOI: 10.4088/jcp.08m04912gre
03/2010

A Comparison of Antipsychotic Drug-Defined Daily Doses Versus Chlorpromazine Equivalent Doses in Patients With or Without Extrapyramidal Motor Symptoms
Journal of Clinical Psychopharmacology
Alasdair M. Barr and William G. Honer and Joy L. Johnson and Tony K.Y. Wu and Ric M. Procyshyn
DOI: 10.1097/jcp.0b013e3181fab7ca
2010

Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation
Neurobiology of Learning and Memory
Jefferson W. Kinney and Manuel Sanchez-Alavez and Alasdair M. Barr and Jose R. Criado and Jacqueline N. Crawley and M. Margarita Behrens and Steven J. Henriksen and Tamas Bartfai
DOI: 10.1016/j.nlm.2009.06.005
10/2009

Role of estradiol withdrawal in ‘anhedonic’ sucrose consumption: A model of postpartum depression
Physiology & Behavior
Amanda D. Green and Alasdair M. Barr and Liisa A.M. Galea
DOI: 10.1016/j.physbeh.2009.02.020
05/2009

SUBSTANCE ABUSE AS A RISK FACTOR FOR FIRST EPISODE PSYCHOSIS
Schizophrenia Research
William Honer and Geoffrey Smith and Hubert Wong and Donna Lang and William Mac Ewan and Lili Kopala and Tom Ehmann and Karen Tee and Ric Procyshyn and Alasdair Barr
DOI: 10.1016/s0920-9964(08)70163-4
06/2008

Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins
European Journal of Neuroscience
Alasdair M. Barr and Kenneth N. Fish and Athina Markou and William G. Honer
DOI: 10.1111/j.1460-9568.2008.06233.x
05/2008

Self-reported motivation to smoke in schizophrenia is related to antipsychotic drug treatment
Schizophrenia Research
Alasdair M. Barr and Ric M. Procyshyn and Philip Hui and Joy L. Johnson and William G. Honer
DOI: 10.1016/j.schres.2007.11.027
03/2008

A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia
Schizophrenia Research
William J. Panenka and Babak Khorram and Alasdair M. Barr and Geoffrey N. Smith and Donna J. Lang and Lili C. Kopala and Robert A. Vandorpe and William G. Honer
DOI: 10.1016/j.schres.2007.05.002
08/2007

Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activity
Journal of Neurochemistry
Matthew N. Hill and Alasdair M. Barr and W.-S. Vanessa Ho and Erica J. Carrier and Boris B. Gorzalka and Cecilia J. Hillard
DOI: 10.1111/j.1471-4159.2007.04688.x
06/2007

The reelin receptors VLDLR and ApoER2 regulate sensorimotor gating in mice
Neuropharmacology
Alasdair M. Barr and Kenneth N. Fish and Athina Markou
DOI: 10.1016/j.neuropharm.2006.11.011
03/2007

Determination of Clozapine and its Metabolite, Norclozapine in Various Biological Matrices Using High-Performance Liquid Chromatography
Drug Development and Industrial Pharmacy
Micheal Rosland and Priscilla Szeto and Ric Procyshyn and Alasdair M. Barr and Kishor M. Wasan
DOI: 10.1080/03639040701484338
01/2007

Conceptual and Methodological Issues??in the Design of Clinical Trials??of Antipsychotics for the Treatment??of Schizophrenia
CNS Drugs
William G Honer and Allen E Thornton and Megan Sherwood and G ??William MacEwan and Tom S Ehmann and Richard Williams and Lili C Kopala and Ric Procyshyn and Alasdair M Barr
DOI: 10.2165/00023210-200721090-00001
2007

Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats
Neuropharmacology
Alasdair M. Barr and Susan B. Powell and Athina Markou and Mark A. Geyer
DOI: 10.1016/j.neuropharm.2006.04.004
09/2006

A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests
Neuroscience Letters
Alasdair M. Barr and Jefferson W. Kinney and Matthew N. Hill and Xiaoying Lu and Shannon Biros and Julius Rebek and Tamas Bartfai
DOI: 10.1016/j.neulet.2006.06.033
09/2006

Relevance of Presynaptic Proteins to Neuropsychiatric Disorders
Molecular Mechanisms of Synaptogenesis
Alasdair M. Barr and Clint E. Young and Ken Sawada and William G. Honer
DOI: 10.1007/978-0-387-32562-0_27
2006

Prenatal Ethanol Exposure in Rats Decreases Levels of Complexin Proteins in the Frontal Cortex
Alcoholism: Clinical & Experimental Research
Alasdair M. Barr and Candace E. Hofmann and Anthony G. Phillips and Joanne Weinberg and William G. Honer
DOI: 10.1097/01.alc.0000187806.68957.0a
11/2005

Selective effects of typical antipsychotic drugs on SNAP-25 and synaptophysin in the hippocampal trisynaptic pathway
The International Journal of Neuropsychopharmacology
Alasdair M. Barr and Clint E. Young and Anthony G. Phillips and William G. Honer
DOI: 10.1017/s1461145705006000
09/2005

Hippocampal Complexin Proteins and Cognitive Dysfunction in Schizophrenia
Archives of General Psychiatry
Ken Sawada and Alasdair M. Barr and Masato Nakamura and Kunimasa Arima and Clint E. Young and Andrew J. Dwork and Peter Falkai and Anthony G. Phillips and William G. Honer
DOI: 10.1001/archpsyc.62.3.263
03/2005

Psychostimulant withdrawal as an inducing condition in animal models of depression
Neuroscience & Biobehavioral Reviews
Alasdair M. Barr and Athina Markou
DOI: 10.1016/j.neubiorev.2005.03.012
01/2005

Galanin receptors as novel drug targets for the treatment of depression and anxiety
Drug Development Research
Xiaoying Lu and Alasdair M. Barr and Tamas Bartfai
DOI: 10.1002/ddr.20026
2005

Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease
Experimental Neurology
Jeremy M. Van Raamsdonk and Jacqueline Pearson and Daniel A. Rogers and Ge Lu and Vilte E. Barakauskas and Alasdair M. Barr and William G. Honer and Michael R. Hayden and Blair R. Leavitt
DOI: 10.1016/j.expneurol.2005.07.021
2005

The Selective Serotonin-2A Receptor Antagonist M100907 Reverses Behavioral Deficits in Dopamine Transporter Knockout Mice
Neuropsychopharmacology
Alasdair M Barr and Virginia Lehmann-Masten and Martin Paulus and Raul R Gainetdinov and Marc G Caron and Mark A Geyer
DOI: 10.1038/sj.npp.1300343
11/2003

Role of Integrin-Linked Kinase in Nerve Growth Factor-Stimulated Neurite Outgrowth
The Journal of Neuroscience
Julia Mills and Murat Digicaylioglu and Arthur T. Legg and Clint E. Young and Sean S. Young and Alasdair M. Barr and Lauren Fletcher and Timothy P. O'Connor and Shoukat Dedhar
DOI: 10.1523/jneurosci.23-05-01638.2003
03/2003

High levels of estradiol impair spatial performance in the Morris water maze and increase ‘depressive-like’ behaviors in the female meadow vole
Physiology & Behavior
Liisa A.M Galea and Tiffany T.-Y Lee and Xanthoula Kostaras and Jesse A Sidhu and Alasdair M Barr
DOI: 10.1016/s0031-9384(02)00849-1
11/2002

A ‘crash’ course on psychostimulant withdrawal as a model of depression
Trends in Pharmacological Sciences
Alasdair M Barr and Athina Markou and Anthony G Phillips
DOI: 10.1016/s0165-6147(02)02086-2
10/2002

Increased successive negative contrast in rats withdrawn from an escalating-dose schedule of d-amphetamine
Pharmacology Biochemistry and Behavior
Alasdair M. Barr and Anthony G. Phillips
DOI: 10.1016/s0091-3057(01)00664-5
01/2002

Repeated electroconvulsive shock attenuates the depressive-like effects of d-amphetamine withdrawal on brain reward function in rats
Psychopharmacology
Alasdair M. Barr and Athanasios P. Zis and Anthony G. Phillips
DOI: 10.1007/s002130100906
09/2001

Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression
Behavioural Brain Research
Liisa A.M Galea and Jennifer K Wide and Alasdair M Barr
DOI: 10.1016/s0166-4328(01)00170-x
07/2001

Paradoxical effects of chronic corticosterone on forced swim behaviours in aged male and female rats
European Journal of Pharmacology
Lori A Brotto and Boris B Gorzalka and Alasdair M Barr
DOI: 10.1016/s0014-2999(01)01148-7
07/2001

Chronic corticosterone enhances the rewarding effect of hypothalamic self-stimulation in rats
Brain Research
Alasdair M Barr and Lori A Brotto and Anthony G Phillips
DOI: 10.1016/s0006-8993(00)02652-4
09/2000

Sex differences in forced-swim and open-field test behaviours after chronic administration of melatonin
European Journal of Pharmacology
Lori A Brotto and Alasdair M Barr and Boris B Gorzalka
DOI: 10.1016/s0014-2999(00)00491-x
08/2000

Effects of Withdrawal from an Escalating Dose Schedule of d-Amphetamine on Sexual Behavior in the Male Rat
Pharmacology Biochemistry and Behavior
Alasdair M Barr and Dennis F Fiorino and Anthony G Phillips
DOI: 10.1016/s0091-3057(99)00156-2
11/1999

Chronic mild stress has no effect on responding by rats for sucrose under a progressive ratio schedule
Physiology & Behavior
Alasdair M Barr and Anthony G Phillips
DOI: 10.1016/s0031-9384(98)00060-2
07/1998

Stimulation of the Ventral Subiculum of the Hippocampus Evokes Glutamate Receptor-mediated Changes in Dopamine Efflux in the Rat Nucleus Accumbens
European Journal of Neuroscience
Charles D. Blaha and Charles R. Yang and Stan B. Floresco and Alasdair M. Barr and Anthony G. Phillips
DOI: 10.1111/j.1460-9568.1997.tb01441.x
05/1997

Effects of chronic mild stress on motivation for sucrose: mixed messages
Psychopharmacology
A. G. Phillips and Alasdair M. Barr
DOI: 10.1007/s002130050469
1997

Research
Research Group Members

Jehan Alamri
Leo Huang, Directed Studies Student
David Kim, Doctoral Student
Zainab Mizban, Masters Student
Jade Yau
Kiki Yu, Undergraduate Student
Jessica Yuen, PhD Student