Overview

My research explores how exercise affects the development of the heart and arteries. While substantial evidence exists demonstrating the beneficial effects of physical activity on cardiovascular disease risk, we do not have a clear understanding of how regular exercise can change the structure and function of our heart and vascular system, and how this differs in men and women. Gaining knowledge in this area is important for us to effectively prescribe exercise for the prevention or treatment of cardiovascular disease.

Publications

Intimal thickening at coronary bifurcations in pediatric heart transplant recipients.
Pediatric transplantation
Duncombe SL and Hosking MCK and Coté AT and Voss C and Harris KC
DOI: 10.1111/petr.13100
PubMed: 29266632
12/2017

A Doppler Echocardiographic Study of the Myocardial Inotropic Response to Peak Semisupine Exercise in Healthy Children: Development of a Simplified Index of Myocardial Reserve
Journal of the American Society of Echocardiography
Anita T. Cote and D. Kathryn Duff and Carolina A. Escudero and Astrid M. De Souza and Lindsey D. Williams and Raman Gill and M. Terri Zadorsky and Kevin C. Harris and James E. Potts and George G.S. Sandor
DOI: 10.1016/j.echo.2017.04.008
08/2017

A Systematic Review of Infective Endocarditis in Patients With Bovine Jugular Vein Valves Compared With Other Valve Types.
Sharma A and Cote AT and Hosking MCK and Harris KC
DOI: 10.1016/j.jcin.2017.04.025
PubMed: 28728659
07/2017

Non-linear Heart Rate and Blood Pressure Interaction in Response to Lower-Body Negative Pressure.
Frontiers in physiology
Verma AK and Xu D and Garg A and Cote AT and Goswami N and Blaber AP and Tavakolian K
DOI: 10.3389/fphys.2017.00767
PubMed: 29114227
2017

Sex Differences in Cardiac Function After Prolonged Strenuous Exercise
Clinical Journal of Sport Medicine
Anita T. Cote and Aaron A. Phillips and Heather J. Foulds and Sarah A. Charlesworth and Shannon S.D. Bredin and Jamie F. Burr and Michael S. Koehle and Darren E.R. Warburton
DOI: 10.1097/jsm.0000000000000130
05/2015

Initial Screening of Children Treated with Second-Generation Antipsychotics Points to an Association between Physical Activity and Insulin Resistance
Pediatric Exercise Science
Anita T. Cote and Angela M. Devlin and Constadina Panagiotopoulos
DOI: 10.1123/pes.2014-0076
11/2014

Greater autonomic modulation during post-exercise hypotension following high-intensity interval exercise in endurance-trained men and women
European Journal of Applied Physiology
Anita T. Cote and Shannon S. D. Bredin and Aaron A. Phillips and Michael S. Koehle and Darren E. R. Warburton
DOI: 10.1007/s00421-014-2996-5
09/2014

Increased Central Arterial Stiffness Explains Baroreflex Dysfunction in Spinal Cord Injury
Journal of Neurotrauma
Aaron A. Phillips and Andrei V. Krassioukov and Philip N. Ainslie and Anita T. Cote and Darren E.R. Warburton
DOI: 10.1089/neu.2013.3280
06/2014

Characterisation of baroreflex sensitivity of recreational ultra-endurance athletes
European Journal of Sport Science
Heather J. A. Foulds and Anita T. Cote and Aaron A. Phillips and Sarah A. Charlesworth and Shannon S. D. Bredin and Jamie F. Burr and Chipman Taylor Drury and Shirley Ngai and Renee J. Fougere and Adam C. Ivey and Darren E. R. Warburton
DOI: 10.1080/17461391.2014.884169
03/2014

Left ventricular mechanics and arterial-ventricular coupling following high-intensity interval exercise
Journal of Applied Physiology
A. T. Cote and S. S. D. Bredin and A. A. Phillips and M. S. Koehle and M. B. Glier and A. M. Devlin and D. E. R. Warburton
DOI: 10.1152/japplphysiol.00576.2013
09/2013

Aortic Stiffness Increased in Spinal Cord Injury When Matched for Physical Activity
Medicine & Science in Sports & Exercise
AARON A. PHILLIPS and ANITA T. COTE and SHANNON S. D. BREDIN and ANDREI V. KRASSIOUKOV and DARREN E. R. WARBURTON
DOI: 10.1249/mss.0b013e3182632585
11/2012

Aortic distensibility is reduced during intense lower body negative pressure and is related to low frequency power of systolic blood pressure
European Journal of Applied Physiology
Aaron A. Phillips and Shannon S. D. Bredin and Anita T. Cote and C. Taylor Drury and Darren E. R. Warburton
DOI: 10.1007/s00421-012-2489-3
09/2012

A segmental evaluation of arterial stiffness before and after prolonged strenuous exercise
Applied Physiology, Nutrition, and Metabolism
Aaron A. Phillips and Anita T. Cote and Heather J. Foulds and Sarah Charlesworth and Shannon S.D. Bredin and Jamie F. Burr and Shirley Ngai and Adam Ivey and C. Taylor Drury and Renee J. Fougere and Darren E.R. Warburton
DOI: 10.1139/h2012-042
08/2012

Heart Disease and Left Ventricular Rotation – A Systematic Review and Quantitative Summary
BMC Cardiovascular Disorders
Aaron A Phillips and Anita T Cote and Shannon SD Bredin and Darren ER Warburton
DOI: 10.1186/1471-2261-12-46
06/2012

Predictors of orthostatic intolerance in healthy young women
Clinical & Investigative Medicine
Anita T Cote and Shannon SD Bredin and Aaron A Phillips and Darren ER Warburton
DOI: 10.25011/cim.v35i2.16290
04/2012

A questionable association of stroke volume and arterial pulse pressure under gravitational stress
The Journal of Trauma and Acute Care Surgery
Anita T. Cote and Aaron A. Phillips and Shannon S. D. Bredin and Darren E. R. Warburton
DOI: 10.1097/ta.0b013e31822dd202
03/2012

Systemic Arterial Compliance Following Ultra-Marathon
International Journal of Sports Medicine
J. Burr and S.S. Bredin and A. Phillips and H. Foulds and A. Cote and S. Charlesworth and A. Ivey and T. Drury and R. Fougere and D.E. Warburton
DOI: 10.1055/s-0031-1297956
01/2012

Comparing the Finapres and Caretaker Systems for Measuring Pulse Transit Time Before and After Exercise
International Journal of Sports Medicine
A. Phillips and J. Burr and A. Cote and H.J. Foulds and S. Charlesworth and S.S. Bredin and D.E. Warburton
DOI: 10.1055/s-0031-1291185
11/2011

Arterial Compliance Decreases Following Ultra-Endurance Competition
Medicine & Science in Sports & Exercise
Jamie F. Burr and Shannon SD Bredin and Sarah Charlesworth and Heather Foulds and Anita Cote and Aaron Phillips and Adam Ivey and Taylor Drury and Shirley Ngai and Renee Fougere and Darren E.R. Warburton
DOI: 10.1249/01.mss.0000401250.66175.b7
05/2011

Baroreceptor Sensitivity in Active Organ Transplant Patients
Medicine & Science in Sports & Exercise
Anita T. Cote and Mark J. Haykowsky and Shannon SD Bredin and Aaron A. Phillips and Ben T. Esch and Darren ER Warburton
DOI: 10.1249/01.mss.0000401275.33895.36
05/2011

The Physiologic Profile Of Ultra-endurance Competitors In Comparison To Healthy Controls
Medicine & Science in Sports & Exercise
Adam Ivey and Jamie Burr and Darren E.R. Warburton and Shannon S.D. Bredin and Aaron Phillips and Anita Cote and Taylor Drury and Heather Foulds and Shirley Ngai and Renee Fougere and Sarah Charlesworth
DOI: 10.1249/01.mss.0000402085.68082.08
05/2011

A systematic review of exercise as a therapeutic intervention to improve arterial function in persons living with spinal cord injury
Spinal Cord
A A Phillips and A T Cote and D E R Warburton
DOI: 10.1038/sc.2010.193
02/2011

Research

Current Projects
I am conducting clinical research in cardiology at BCCH with Drs. Harris and Sandor, as well as transplant rehabilitation program development with Dr. Tom Blyndt-Hansen.
Some of the research I am conducting include:

Left ventricular mechanics during exercise in pediatric heart transplant recipients

Physical activity, aerobic capacity, and cardiovascular function in pediatric heart transplant

Normal myocardial responses to exercise in healthy children

Grants

2016 Rare Disease Foundation and BC Children’s Hospital Foundation Grant ($2700 CDN), Principle Investigator Title: Aortic Stiffness and Cardiac Allograft Vasculopathy in Children With Critical Heart Disease Requiring Transplantation

2016 BC Transplant Foundation Venture Grant ($24,794), Co-Investigator Title: Optical Coherence Tomography Imaging for Early Detection of Cardiac Allograft Vasculopathy in Pediatric Heart Transplant

2015 Rare Disease Foundation and BC Children’s Hospital Foundation Grant ($3,450 CDN), Co-Investigator Title: Assessing the Variability and Clinical Utility of an Echo-Doppler Method to Measure Aortic Stiffness in Marfan syndrome and Related Rare Diseases with Dilated Aortopathy

Honours & Awards

2014 Young Investigator Award, Canadian Society for Atherosclerosis Thrombosis and Vascular Biology, $250

2013-2016 Michael Smith Foundation for Health Research Postdoctoral Fellowship, $124,500

2015 Poster Presentation Award, Pediatrics Research Day