Asthma and allergy involves interaction of the individual person with their environment and involves both genetic and environmental factors. Modifying the environment of those who are at risk of developing allergy and asthma may be important in prevention or modifying the severity of disease. Understanding the underlying changes in the tissues which lead to symptoms and assessing the beneficial, and possible adverse, effects of therapy will lead to optimal treatment and the best outcome for children affected.
Development of a novel method for assessing levels of nitric oxide in nasal air which can be used as a non-invasive test for nasal allergy and inflammation.
Randomized, controlled studies comparing the efficacy and adverse effects of different inhaled corticosteroids for asthma. Recent findings are of a progressive decrease in growth velocity in school aged children over a 12-month treatment period with one commonly used medication compared to another.
A multifaceted intervention study starting before birth in 500 children who are at high risk of developing asthma and allergy has been in progress since 1995, with the most recent assessment (age 7 years) currently underway. The study assesses the effect on asthma and allergy symptoms and development of specific allergies and bronchial hyperresponsiveness, growth and development and genetic markers.Early findings are of a 35% reduction in wheezing illness at age 2 to 4 years and an increased proportion of children with specific susceptibility genes.Honours & Awards
Best Doctors in Canada - 1998
Charles T. Fried Lectureship, University of Alberta - 1991