Audi Setiadi
MD
Investigator and Hematopathologist, BC Children's Hospital
Journal of Experimental Medicine
Maggie P. Fu and Mehul Sharma and Pariya Yousefi and Sarah M. Merrill and Ryan Tan and Simran Samra and Audi Setiadi and Liam Golding and Bhavi P. Modi and Kate L. Del Bel and Rebecca J. Deyell and Jacob Rozmus and Wingfield Rehmus and Kyla J. Hildebrand and Elliot James and Graldine Blanchard-Rohner and Susan Lin and Kevin E. Shopsowitz and Jefferson Terry and Anna F. Lee and Britt I. Drgemller and Allison Matthews and Maja Tarailo-Graovac and Laura Sauv and Hana Mitchell and Julie S. Prendiville and Julia L. MacIsaac and Kristy Dever and David T.S. Lin and Mandy Meijer and Colin J.D. Ross and Simon R.M. Dobson and Suzanne M. Vercauteren and Wyeth W. Wasserman and Clara D.M. van Karnebeek and Margaret L. McKinnon and Michael S. Kobor and Stuart E. Turvey and Catherine M. Biggs
DOI: 10.1084/jem.2024094510 / 2025
eJHaem
Ali Amid and Elona Turley and Nicholas Au and Audi Setiadi
DOI: 10.1002/jha2.7007708 / 2025
European Journal of Haematology
Beckett, M. and Spaner, C. and Goubran, M. and Wade, J. and Avina-Zubieta, J.A. and Setiadi, A. and Tucker, L. and Shojania, K. and Au, S. and Mattman, A. and Lee, A.Y.Y. and Fajgenbaum, D.C. and Chen, L.Y.C.
DOI: 10.1111/ejh.14267British Journal of Haematology
Loyzer, M.N. and Setiadi, A.
DOI: 10.1111/bjh.19566Pediatric Blood and Cancer
Setiadi, A. and Singh, C. and Li, A. and Au, N. and Amid, A.
DOI: 10.1002/pbc.30771Pediatric Allergy and Immunology
Duke, S. and Maiarana, J. and Yousefi, P. and Burks, E. and Gerrie, S. and Setiadi, A. and Amid, A. and Boerkel, C. and Erdle, S. and Guttman, O. and Kanani, A. and Lawrence, S. and Lee, A.F. and Pourshahnazari, P. and Rayar, M. and Rozmus, J. and Schrader, D. and Sharma, M. and Shopsowitz, K.E. and Tan, R. and To, F. and Yang, C. and Hildebrand, K.J. and James, E. and Turvey, S.E. and Markle, J.G. and Biggs, C.M.
DOI: 10.1111/pai.14077Research Square
Goubran, M. and Spaner, C. and Stukas, S. and Zoref-Lorenz, A. and Shojania, K. and Beckett, M. and Li, A. and Peterson, E. and Sekhon, M. and Grey, R. and Wellington, C. and Cheng, C.V. and Biggs, C.M. and Mattman, A. and Jordan, M.B. and Chen, L.Y.C. and Setiadi, A.
DOI: 10.21203/rs.3.rs-4798637/v1Audi Setiadi and Claudia Singh and Amanda Li and Nicholas Au and Ali Amid
DOI: 10.22541/au.169468925.50466482/v109 / 2023
Journal of Clinical Immunology
Tan, R. and Lu, H.Y. and Sharma, M. and Sandhu, H. and Harris, K.C. and Cameron, S.B. and Setiadi, A. and Hildebrand, K.J. and Rozmus, J. and Turvey, S.E. and Biggs, C.M.
DOI: 10.1007/s10875-023-01489-5Cancer Cell
Lambo, S. and Trinh, D.L. and Ries, R.E. and Jin, D. and Setiadi, A. and Ng, M. and Leblanc, V.G. and Loken, M.R. and Brodersen, L.E. and Dai, F. and Pardo, L.M. and Ma, X. and Vercauteren, S.M. and Meshinchi, S. and Marra, M.A.
DOI: 10.1016/j.ccell.2023.10.008medRxiv
Lu, H.Y. and Vaseghi-Shanjani, M. and Lam, A.J. and Sharma, M. and Mohajeri, A. and Gillies, J. and Yang, G.X. and Lin, S. and Fu, M.P. and Salman, A. and Rahmanian, R. and Armstrong, L. and Halparin, J. and Yang, C.L. and Chilvers, M. and Henkelman, E. and Rehmus, W. and Morrison, D. and Setiadi, A. and Mostafavi, S. and Kobor, M.S. and Kozak, F.K. and Biggs, C.M. and van Karnebeek, C. and Hildebrand, K.J. and Lehman, A. and Levings, M.K. and Turvey, S.E.
DOI: 10.1101/2023.09.09.23295301medRxiv
Fu, M.P. and Sharma, M. and Merrill, S.M. and Yousefi, P. and Tan, R. and Modi, B.P. and Bel, K.D. and Deyell, R.J. and Rozmus, J. and Rehmus, W. and Hildebrand, K.J. and James, E. and Blanchard-Rohner, G. and Lin, S. and Shopsowitz, K.E. and Setiadi, A. and Terry, J. and Lee, A.F. and Drgemller, B.I. and Matthews, A. and Tarailo-Graovac, M. and Sauv, L. and Mitchell, H. and Prendiville, J.S. and MacIsaac, J.L. and Dever, K. and Lin, D.T.S. and Meijer, M. and Ross, C.J.D. and Dobson, S.R.M. and Vercauteren, S.M. and Wasserman, W.W. and van Karnebeek, C.D.M. and McKinnon, M.L. and Kobor, M.S. and Turvey, S.E. and Biggs, C.M.
DOI: 10.1101/2023.12.20.23300096British Journal of Haematology
Lai, C.M.B. and Setiadi, A. and Barlas, A. and Kanani, A. and Pourshahnazari, P. and Leitch, H.A. and Metzger, D.L. and Merkeley, H. and Biggs, C.M.
DOI: 10.1111/bjh.17866The Lancet Haematology
Setiadi, A. and Zoref-Lorenz, A. and Lee, C.Y. and Jordan, M.B. and Chen, L.Y.C.
DOI: 10.1016/S2352-3026(21)00366-5medRxiv
Sharma, M. and Fu, M.P. and Lu, H.Y. and Sharma, A.A. and Modi, B.P. and Michalski, C. and Lin, S. and Dalmann, J. and Salman, A. and Del Bel, K.L. and Waqas, M. and Terry, J. and Setiadi, A. and Lavoie, P.M. and Wasserman, W.W. and Mwenifumbo, J. and Kobor, M.S. and Lee, A.F. and Lehman, A. and Cheng, S. and Cooper, A. and Patel, M.S. and Turvey, S.E.
DOI: 10.1101/2022.01.30.22269378The Lancet Infectious Diseases
Spaner, C. and Goubran, M. and Setiadi, A. and Chen, L.Y.C.
DOI: 10.1016/S1473-3099(22)00348-6Cytometry Part B - Clinical Cytometry
Shopsowitz, K.E. and Liu, L. and Setiadi, A. and Al-Bakri, M. and Vercauteren, S.
DOI: 10.1002/cyto.b.22084Blood
Sharma, M. and Fu, M.P. and Lu, H.Y. and Sharma, A.A. and Modi, B.P. and Michalski, C. and Lin, S. and Dalmann, J. and Salman, A. and Del Bel, K.L. and Waqas, M. and Terry, J. and Setiadi, A. and Lavoie, P.M. and Wasserman, W.W. and Mwenifumbo, J. and Kobor, M.S. and Lee, A.F. and Kuchenbauer, F. and Lehman, A. and Cheng, S. and Cooper, A. and Patel, M.S. and Turvey, S.E.
DOI: 10.1182/blood.2022015674American Journal of Hematology
Al-Bakri, M. and Terry, J. and Chipperfield, K. and Morrison, D. and Setiadi, A.
DOI: 10.1002/ajh.26624eJHaem
Maryam Al Bakri and Audi Setiadi
DOI: 10.1002/jha2.12502 / 2021
Cytometry Part B - Clinical Cytometry
McGinnis, E. and Yang, D. and Au, N. and Morrison, D. and Chipperfield, K.M. and Setiadi, A.F. and Liu, L. and Tsang, A. and Vercauteren, S.M.
DOI: 10.1002/cyto.b.21966Journal of Hematopathology
Al Moosawi, M. and Vawda, A. and Setiadi, A.
DOI: 10.1007/s12308-021-00445-9BMJ Case Reports
Setiadi, A.F. and Sheikine, Y.
DOI: 10.1136/bcr-2019-232233International Journal of Laboratory Hematology
Setiadi, A. and Owen, D. and Tsang, A. and Milner, R. and Vercauteren, S.
DOI: 10.1111/ijlh.12535Developmental Cell
Chang, A. and Fu, Y. and Garside, V. and Niessen, K. and Chang, L. and Fuller, M. and Setiadi, A. and Smrz, J. and Kyle, A. and Minchinton, A. and Marra, M. and Hoodless, P. and Karsan, A.
DOI: 10.1016/j.devcel.2011.06.022Journal of Biological Chemistry
Fu, Y.X. and Chang, A. and Chang, L. and Niessen, K. and Eapen, S. and Setiadi, A. and Karsan, A.
DOI: 10.1074/jbc.M109.011833Minimal residual disease refers to a small number of malignant cells that remain in the patient during or after treatment when the patient has no signs or symptoms of the disease. Flow cytometry allows for MRD analysis by looking at different expression of cellular antigens on malignant cells compared to normal cells. As part of Dr. Suzanne Vercauteren’s team, our lab has implemented 10-color flow cytometry panels for MRD detection in B-cell acute lymphoblastic leukemia (the most common type of blood cancer in children) post chemotherapy and post CD19 directed therapy. In collaboration with the BRAVe initiative, we are currently looking at more markers to identify leukemic stem cell populations, which may contribute to relapse or treatment resistance.
PIDDs are a heterogeneous group of inherited disorders resulting from genetic defects that impair the immune system. Given the complexity of the immune system, the clinical manifestations of PIDDs are highly variable and may present with recurrent infections, autoimmunity and predisposition to cancer. Under the “Diseases of Immune Dysregulation” group of PIDD is a life threatening disorder called Hemophagocytic Lymphohistiocytosis (HLH), leading to an overactive, dysfunctional response of immune system, low blood cell counts and multi-organ damage. Our lab implemented clinical flow cytometry panels to support newborn screening for severe combined immunodeficiency (SCID) and expand the investigation for PIDD, as well as Perforin assay for screening of primary HLH. We continue to optimize our assay methodologies and reference ranges to support the diagnosis of PIDD in BC.
Our lab is validating several flow cytometry panels for product assessment of several graft engineering projects under TRACE initiative, including T-cell alpha/beta depleted stem cell transplantation to reduce GvHD risk, as well as viral specific T-cell therapy for severe protracted viral infection post-transplant.
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