Dr. Singhal is involved and interested in a multitude of pediatric neurosurgery topics, however his main interests are head injuries and their causes, consequences and interactions with the environment. His research employs leading-edge imaging technologies as well as the study of potentially underlying environmental and genomic factors that may contribute to disease progression and outcome. Another major research focus is the monitoring and study of post-operative status, management and outcome of neurosurgery patients.


An Educational Video Improves Consent in Pediatric Lumbar Puncture: A Randomized Control Trial
Pediatric Neurology
Mary Dunbar and Gillian Paton and Ashutosh Singhal
DOI: 10.1016/j.pediatrneurol.2019.04.014

Outcomes and complications for individual neurosurgeons for the treatment of Chiari I malformation at a children’s hospital
Child's Nervous System
Tasha-Kay Walker-Palmer and D. Douglas Cochrane and Ashutosh Singhal and Paul Steinbok
DOI: 10.1007/s00381-019-04201-4

Impact of work hours and sleep on well-being and burnout for physicians-in-training: the Resident Activity Tracker Evaluation Study
Medical Education
Daniel Mendelsohn and Ivan Despot and Peter A Gooderham and Ashtush Singhal and Gary J Redekop and Brian D Toyota
DOI: 10.1111/medu.13757

Eight-year outcome of implementation of abusive head trauma prevention
Child Abuse & Neglect
Ronald G. Barr and Marilyn Barr and Fahra Rajabali and Claire Humphreys and Ian Pike and Rollin Brant and Jean Hlady and Margaret Colbourne and Takeo Fujiwara and Ash Singhal
DOI: 10.1016/j.chiabu.2018.07.004

International survey on the management of Chiari 1 malformation and syringomyelia: evolving worldwide opinions
Child's Nervous System
Ash Singhal and Alexander Cheong and Paul Steinbok
DOI: 10.1007/s00381-018-3741-x

MRI in mild pediatric traumatic brain injury: diagnostic overkill or useful tool?
Child's Nervous System
Gesa Cohrs and Monika Huhndorf and Nils Niemczyk and Lukas J. Volz and Alexander Bernsmeier and Ash Singhal and Naomi Larsen and Michael Synowitz and Friederike Knerlich-Lukoschus
DOI: 10.1007/s00381-018-3771-4

Bobble-head doll syndrome: report of 2 cases and a review of the literature, with video documentation of the clinical phenomenon
Journal of Neurosurgery: Pediatrics
Bryan Renne and Stefan Rueckriegel and Sudheesh Ramachandran and Julia Radic and Paul Steinbok and Ash Singhal
DOI: 10.3171/2017.9.peds16704

Cranioplasties following craniectomies in children—a multicenter, retrospective cohort study
Child's Nervous System
Vita M. Klieverik and Kai J. Miller and Kuo Sen Han and Ash Singhal and Michael Vassilyadi and Charles J. Touchette and Alexander G. Weil and Peter A. Woerdeman
DOI: 10.1007/s00381-018-4024-2

Examining the need for routine intensive care admission after surgical repair of nonsyndromic craniosynostosis: a preliminary analysis
Journal of Neurosurgery: Pediatrics
Christopher M. Bonfield and Jade Basem and D. Douglas Cochrane and Ash Singhal and Paul Steinbok
DOI: 10.3171/2018.6.peds18136

Correction to: Challenges in minor TBI and indications for head CT in pediatric TBI—an update
Child's Nervous System
Navneet Singh and Ash Singhal
DOI: 10.1007/s00381-017-3608-6

Challenges in minor TBI and indications for head CT in pediatric TBI—an update
Child's Nervous System
Navneet Singh and Ash Singhal
DOI: 10.1007/s00381-017-3535-6

Video Diversion Improves Success Rate of Fundoscopic Examination in Children: a Prospective Randomized Controlled Trial
Pediatric Neurology
Michael M.H. Yang and Ash Singhal and Alexander R. Hengel and John M. Kerr and Godefroy Hardy St-Pierre and Shawn George and Katherine Muir and Paul Thiessen and Paul Enarson
DOI: 10.1016/j.pediatrneurol.2017.09.008

State of global pediatric neurosurgery outreach: survey by the International Education Subcommittee
Journal of Neurosurgery: Pediatrics
Matthew C. Davis and Brandon G. Rocque and Ash Singhal and Thomas Ridder and Jogi V. Pattisapu and James M. Johnston
DOI: 10.3171/2017.3.peds16433

Manifestations of Tuberous Sclerosis Complex: The Experience of a Provincial Clinic
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Colin Wilbur and Chinnuwat Sanguansermsri and Hedi Chable and Mihaela Anghelina and Sharon Peinhof and Kelly Anderson and Paul Steinbok and Ash Singhal and Anita Datta and Mary B. Connolly
DOI: 10.1017/cjn.2016.311

Regression of ventriculomegaly following medical management of a patient with Hurler syndrome
Journal of Neurosurgery: Pediatrics
Jennifer Liang and Ash Singhal
DOI: 10.3171/2015.9.peds15477

Impact of Early Follow-Up Intervention on Parent-Reported Postconcussion Pediatric Symptoms
Journal of Head Trauma Rehabilitation
Patricia Mortenson and Ashutosh Singhal and Alexander R. Hengel and Jacqueline Purtzki
DOI: 10.1097/htr.0000000000000223

Establishing MRI in the acute pediatric mild traumatic brain injury setting
German Medical Science GMS Publishing House
DOI: 10.3205/16DGNC433

Preoperative ultrasound localization of the lambda in patients with scaphocephaly: a technical note for minimally invasive craniectomy
Journal of Neurosurgery: Pediatrics
Christopher M. Bonfield and D. Douglas Cochrane and Ash Singhal and Paul Steinbok
DOI: 10.3171/2015.5.peds15157

Intracystic interferon-a treatment leads to neurotoxicity in craniopharyngioma: case report
Journal of Neurosurgery: Pediatrics
Julia Sharma and Christopher M. Bonfield and Ash Singhal and Juliette Hukin and Paul Steinbok
DOI: 10.3171/2015.2.peds14656

Minimizing blood transfusions in the surgical correction of craniosynostosis: a 10-year single-center experience.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
DOI: 10.1007/s00381-015-2900-6
PubMed: 26351073

Intraoperative ultrasound in pediatric brain tumors: does the surgeon get it right?
Child's Nervous System
Ash Singhal and A. Ross Hengel and Paul Steinbok and D. Doug Cochrane
DOI: 10.1007/s00381-015-2805-4

Hypothermia for Traumatic Brain Injury in Children—A Phase II Randomized Controlled Trial*
Critical Care Medicine
John Beca and Brent McSharry and Simon Erickson and Michael Yung and Andreas Schibler and Anthony Slater and Barry Wilkins and Ash Singhal and Gary Williams and Claire Sherring and Warwick Butt
DOI: 10.1097/ccm.0000000000000947

Neurosurgery (Pediatric Neurosurgery)
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
MM Yang and A Singhal and N Au and AR Hengel
DOI: 10.1017/cjn.2015.217

Evolution of a Pediatric Primary Cerebral ALK-1-Positive Anaplastic Large Cell Lymphoma on Serial MRI
Pediatric Neurosurgery
Mary J. Dunbar and Ash Singhal and Shahrad Rod Rassekh and Christopher Dunham
DOI: 10.1159/000380769

Impact of preoperative laboratory investigation and blood cross-match on clinical management of pediatric neurosurgical patients
Child's Nervous System
Michael M. H. Yang and Ash Singhal and Nicholas Au and A. Ross Hengel
DOI: 10.1007/s00381-015-2617-6

Central Nervous System Germ Cell Tumors (CNS-GCT)
Pediatric Neuro-oncology
Ute Bartels and Ash Singhal
DOI: 10.1007/978-1-4939-1541-5_14

Video Diversion During Fundoscopic Examination in Children
Journal of Child Neurology
Ash Singhal and Michael M.H. Yang and John M. Kerr
DOI: 10.1177/0883073813483363

Traumatic brain injury and critical care management in the pediatric population
Neurosurgery Knowledge Update (Harbaugh eds)

Neurointensive Care for Head Injuries
Pediatric Neurosurgery Tricks of the Trade (Cohen, A. eds)

CSF complications following intradural spinal surgeries in children
Child's Nervous System
Victor Liu and Christopher Gillis and Doug Cochrane and Ash Singhal and Paul Steinbok
DOI: 10.1007/s00381-013-2276-4

Personalizing the Treatment of Pediatric Medulloblastoma: Polo-like Kinase 1 as a Molecular Target in High-Risk Children
Cancer Research
J. Triscott and C. Lee and C. Foster and B. Manoranjan and M. R. Pambid and R. Berns and A. Fotovati and C. Venugopal and K. O'Halloran and A. Narendran and C. Hawkins and V. Ramaswamy and E. Bouffet and M. D. Taylor and A. Singhal and J. Hukin and R. Rassekh and S. Yip and P. Northcott and S. K. Singh and C. Dunham and S. E. Dunn
DOI: 10.1158/0008-5472.can-12-4331

Neurological morbidity of surgical resection of pediatric cerebellar astrocytomas
Child's Nervous System
Paul Steinbok and Jaspreet Singh Mangat and John M. Kerr and Michael Sargent and Wihasto Suryaningtyas and Ashutosh Singhal and Doug Cochrane
DOI: 10.1007/s00381-013-2171-z

Bilateral lambdoid and posterior sagittal craniosynostosis—management, evolution, and outcome
Child's Nervous System
Shibu Pillai and D. Cochrane and A. Singhal and Paul Steinbok
DOI: 10.1007/s00381-013-2155-z

Ring Apophysis Fracture in Pediatric Lumbar Disc Herniation: A Common Entity
Pediatric Neurosurgery
Ash Singhal and Anish Mitra and Doug Cochrane and Paul Steinbok
DOI: 10.1159/000355127

Improper use of child restraint seats as a sleeping environment: Two cases of childhood death
Paediatrics & Child Health
Ash Singhal and Elysia Adams and Ediriweera Desapriya
DOI: 10.1093/pch/17.9.498

Does optic nerve sheath diameter on MRI decrease with clinically improved pediatric hydrocephalus?
Child's Nervous System
Ash Singhal and Michael M. H. Yang and Michael A. Sargent and D. Douglas Cochrane
DOI: 10.1007/s00381-012-1937-z

Consensus definitions of complications for accurate recording and comparisons of surgical outcomes in pediatric neurosurgery
Journal of Neurosurgery: Pediatrics
James M. Drake and Ash Singhal and Abhaya V. Kulkarni and Gabrielle DeVeber and D. Douglas Cochrane and The Canadian Pediatric Neurosurgery Study Group
DOI: 10.3171/2012.3.peds11233

Polo-Like Kinase 1 Inhibition Kills Glioblastoma Multiforme Brain Tumor Cells in Part Through Loss of SOX2 and Delays Tumor Progression in Mice
Cathy Lee and Abbas Fotovati and Joanna Triscott and James Chen and Chitra Venugopal and Ash Singhal and Christopher Dunham and John M. Kerr and Maite Verreault and Stephen Yip and Hiroaki Wakimoto and Chris Jones and Aarthi Jayanthan and Aru Narendran and Sheila K. Singh and Sandra E. Dunn
DOI: 10.1002/stem.1081

Possible differentiation of cerebral glioblastoma into pleomorphic xanthoastrocytoma: an unusual case in an infant
Journal of Neurosurgery: Pediatrics
Michael M. H. Yang and Ash Singhal and Shahrad Rod Rassekh and Stephen Yip and Patrice Eydoux and Christopher Dunham
DOI: 10.3171/2012.1.peds11326

Endoscopic fenestration of cavum velum interpositum cysts: a case study of two symptomatic patients
Child's Nervous System
Calvin K. W. Tong and Ashutosh Singhal and D. Douglas Cochrane
DOI: 10.1007/s00381-012-1770-4

Genetic–environmental interaction in a unique case of Muenke syndrome with intracranial hypertension
Child's Nervous System
Nneamaka B. Agochukwu and Benjamin D. Solomon and Anna Zajaczkowska-Kielska and Christopher J. Lyons and Travis Pollock and Ash Singhal and Margot I. Van Allen and Maximilian Muenke
DOI: 10.1007/s00381-011-1595-6

Stridor at birth predicts poor outcome in neonates with myelomeningocele
Child's Nervous System
Eylem Ocal and Beverly Irwin and Douglas Cochrane and Ash Singhal and Paul Steinbok
DOI: 10.1007/s00381-011-1585-8

Diffusion-weighted imaging and pathological correlation in pediatric medulloblastomas—“They are not always restricted!”
Child's Nervous System
Shibu Pillai and Ash Singhal and Angela T. Byrne and Chris Dunham and D. Douglas Cochrane and Paul Steinbok
DOI: 10.1007/s00381-011-1499-5

Pediatric patients with poor neurological status and arteriovenous malformation hemorrhage: an outcome analysis
Journal of Neurosurgery: Pediatrics
Ash Singhal and Tara Adirim and Doug Cochrane and Paul Steinbok
DOI: 10.3171/2011.2.peds10355

Trends in paediatric sport- and recreation-related injuries: An injury surveillance study at the British Columbia Children's Hospital (Vancouver, British Columbia) from 1992 to 2005
Paediatrics & Child Health
Kaivon Pakzad-Vaezi and Ash Singhal
DOI: 10.1093/pch/16.4.217

Trauma Association of Canada Pediatric Subcommittee National Pediatric Cervical Spine Evaluation Pathway: Consensus Guidelines
The Journal of Trauma: Injury, Infection, and Critical Care
Seen Chung and Angelo Mikrogianakis and Paul W. Wales and Peter Dirks and Manohar Shroff and Ash Singhal and Vincent Grant and B. J. Hancock and David Creery and Jeff Atkinson and Dickens St-Vil and Louis Crevier and Natalie Yanchar and Allen Hayashi and Vivek Mehta and Timothy Carey and Sonny Dhanani and Ron Siemens and Sheila Singh and Dave Price
DOI: 10.1097/ta.0b013e3182108823

Third ventricular shape: a predictor of endoscopic third ventriculostomy success in pediatric patients
Journal of Neurosurgery: Pediatrics
Mansoor Foroughi and Andrew Wong and Paul Steinbok and Ash Singhal and Michael A. Sargent and D. Douglas Cochrane
DOI: 10.3171/2011.1.peds10461

Natural history of untreated syringomyelia in pediatric patients
Neurosurgical Focus
Ash Singhal and Tim Bowen-Roberts and Paul Steinbok and Doug Cochrane and Angela T. Byrne and John M. Kerr
DOI: 10.3171/2011.9.focus11208

Supratentorial Primitive Neuroectodermal Tumors
Oncology of CNS Tumors
Ash Singhal and Shahid Gul and Paul Steinbok
DOI: 10.1007/978-3-642-02874-8_37

Iatrogenic complications following shunting the subarachnoid space in infancy
Cerebrospinal Fluid Research
Douglas Cochrane and Ryan Janicki and Keith Aronyk and Jeff Pugh and Paul Steinbok and Ash Singhal
DOI: 10.1186/1743-8454-7-s1-s13

Ventriculoperitoneal shunt after previous endoscopic third ventriculostomy: does ETV improve shunt survival?
Cerebrospinal Fluid Research
Ash Singhal and Tia Liu and Doug Cochrane and Paul Steinbok
DOI: 10.1186/1743-8454-7-s1-s14

Cingulate Lesions Presenting With Epileptic Spasms
Journal of Clinical Neurophysiology
Dewi Schrader and Lisa Langill and Ash Singhal and Paul Steinbok and Mary B. Connolly
DOI: 10.1097/wnp.0b013e3181baaacf

Conventional and Diffusion-Weighted Magnetic Resonance Imaging Findings in a Pediatric Patient with a Posterior Fossa Brain Tumor and Papilledema
Pediatric Neurosurgery
Kaivon Pakzad-Vaezi and Doug Cochrane and Michael Sargent and Ash Singhal
DOI: 10.1159/000270156

Optic nerve sheath fenestration and bilateral expansile cranioplasty for raised intracranial pressure in craniometaphyseal dysplasia: a case report
Child's Nervous System
Ash Singhal and David D. Cochrane
DOI: 10.1007/s00381-007-0549-5

Long-term outcome of infants with positional occipital plagiocephaly
Child's Nervous System
Paul Steinbok and David Lam and Swati Singh and Patricia A. Mortenson and Ashutosh Singhal
DOI: 10.1007/s00381-007-0373-y

Ascites and abdominal pseudocysts following ventriculoperitoneal shunt surgery: variations of the same theme
Journal of Neurosurgery: Pediatrics
Rajeev Kariyattil and Paul Steinbok and Ashutosh Singhal and D. Douglas Cochrane
DOI: 10.3171/ped.2007.106.5.350

Early Hypodensity on Computed Tomographic Scan of the Brain in an Accidental Pediatric Head Injury
Paul Steinbok and Ashutosh Singhal and Ken Poskitt and D. Douglas Cochrane
DOI: 10.1227/01.neu.0000255398.00410.6b

Gyriform Differentiation in Medulloblastoma – A Radiological Predictor of Histology
Pediatric Neurosurgery
Deepak Agrawal and Ashutosh Singhal and Glenda Hendson and Felix A. Durity
DOI: 10.1159/000098390

Operative management of growing skull fractures: a technical note
Child's Nervous System
Ashutosh Singhal and Paul Steinbok
DOI: 10.1007/s00381-007-0552-x

Complete Upward Migration of the Peritoneal End of a Ventriculoperitoneal Shunt into the Subgaleal Space
Pediatric Neurosurgery
Peter Y.C. Gan and Ash Singhal
DOI: 10.1159/000095575

Near nerve local insulin prevents conduction slowing in experimental diabetes
Brain Research
Ash Singhal and Chu Cheng and Hong Sun and Douglas W Zochodne
DOI: 10.1016/s0006-8993(97)00412-5


Apolipoprotein E and Pediatric Traumatic Brain Injury: A Prospective Observational Study
Traumatic Brain Injury (TBI) is a particularly significant public health issue in children and adolescents, who account for over 50 per cent of new cases of head injury yearly. The causes for this are multi-factorial, but recent studies in adult TBI suggest that a genetic marker, the APOE gene, may play a role in influencing outcomes. We aim to determine if there is a relationship between subtypes of a gene encoding a lipoprotein, Apolipoprotein E, and outcome after pediatric TBI. Our hypothesis is that a genetic allelic subtype, APOE4, is associated with worse outcomes. Children with apparently similar demographic characteristics, mechanism of injury, and apparently similar clinical and radiographic injury patterns have notably different clinical outcomes.

BC Inflicted Childhood Neurotrauma Surveillance Project
The BC Inflicted Childhood Neurotrauma Surveillance Project is a part of Phase II of Preventing Shaken Baby Syndrome and Infant Abuse: The Period of PURPLE Crying Program. It is an active surveillance project that documents traumatic head injury in children less than two years of age.

The Program will be evaluated for its effectiveness in attaining the three primary goals of the intervention:

Attaining a “penetration” rate of 90-95 per cent of mothers of newborn infants
Reducing the incidence of shaken baby syndrome and/or infant abuse by 50 per cent
Achieving a cultural change in the understanding of early infant crying and its relationship to shaken baby syndrome
The surveillance system will also address the crucial need in B.C, for current knowledge of ICN incidence, as well as the challenges of measuring and implications for assessing prevention interventions. The first of its kind in Canada, this system will allow the establishment of a baseline incidence of ICN in B.C. Other objectives include determining the proportion of ICN versus non-inflicted neurotrauma and comparing the key characteristics of children with ICN to those with non-inflicted neurotrauma, and to the population at risk in the age group of 0-2 years old.

Analysis of Pediatric Injuries Related to Child Restraint Seats: Are Children at Higher Risk for Injury Outside the Vehicle Than Inside?
With the increasing popularity of hand-held child restraint seats (CRS), BC Children's Hospital clinicians have noticed an increase in injuries related to the improper use of CRS when used outside of the vehicle. These injuries include falls out of the CRS or falls of both the CRS and child. This potential public heath problem has not previously been studied.

We propose to study the problem on a national basis via coordinated data collection/retrieval in the pediatric trauma centers across the country. By examining pediatric trauma in cases in which a CRS was involved, we might identify what the national incidence and contributing factors of such injuries are. Furthermore, we also hope to determine the anatomical pattern of injury associated with CRS injuries, particularly when associated with improper use of the seat outside the vehicle.

Honours & Awards

Ontario Graduate Scholarship in Science and Techn. Research Award – University of Toronto, 2001

Critical Care Research Award – Canadian Congress of Neurological Sciences, 2003