Overview

Dr. Singhal is involved and interested in a multitude of pediatric neurosurgery topics, however his main interests are head injuries and their causes, consequences and interactions with the environment. His research employs leading-edge imaging technologies as well as the study of potentially underlying environmental and genomic factors that may contribute to disease progression and outcome. Another major research focus is the monitoring and study of post-operative status, management and outcome of neurosurgery patients.

Publications

Correction to: Challenges in minor TBI and indications for head CT in pediatric TBI—an update
Child's Nervous System
Navneet Singh, Ash Singhal
DOI: 10.1007/s00381-017-3608-6
10/2017

Video Diversion Improves Success Rate of Fundoscopic Examination in Children: a Prospective Randomized Controlled Trial
Pediatric Neurology
Michael M.H. Yang, Ash Singhal, Alexander R. Hengel, John M. Kerr, Godefroy Hardy St-Pierre, Shawn George, Katherine Muir, Paul Thiessen, Paul Enarson
DOI: 10.1016/j.pediatrneurol.2017.09.008
09/2017

Challenges in minor TBI and indications for head CT in pediatric TBI—an update
Child's Nervous System
Navneet Singh, Ash Singhal
DOI: 10.1007/s00381-017-3535-6
09/2017

State of global pediatric neurosurgery outreach: survey by the International Education Subcommittee
Journal of Neurosurgery: Pediatrics
Matthew C. Davis, Brandon G. Rocque, Ash Singhal, Thomas Ridder, Jogi V. Pattisapu, James M. Johnston
DOI: 10.3171/2017.3.peds16433
08/2017

Manifestations of Tuberous Sclerosis Complex: The Experience of a Provincial Clinic
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Colin Wilbur, Chinnuwat Sanguansermsri, Hedi Chable, Mihaela Anghelina, Sharon Peinhof, Kelly Anderson, Paul Steinbok, Ash Singhal, Anita Datta, Mary B. Connolly
DOI: 10.1017/cjn.2016.311
11/2016

Regression of ventriculomegaly following medical management of a patient with Hurler syndrome
Journal of Neurosurgery: Pediatrics
Jennifer Liang, Ash Singhal
DOI: 10.3171/2015.9.peds15477
05/2016

Establishing MRI in the acute pediatric mild traumatic brain injury setting
German Medical Science GMS Publishing House
DOI: 10.3205/16DGNC433
2016

Impact of Early Follow-Up Intervention on Parent-Reported Postconcussion Pediatric Symptoms A Feasibility Study
Journal of Head Trauma Rehabilitation
Patricia Mortenson, Ashutosh Singhal, Alexander R. Hengel, Jacqueline Purtzki
DOI: 10.1097/htr.0000000000000223
2016

Preoperative ultrasound localization of the lambda in patients with scaphocephaly: a technical note for minimally invasive craniectomy
Journal of Neurosurgery: Pediatrics
Christopher M. Bonfield, D. Douglas Cochrane, Ash Singhal, Paul Steinbok
DOI: 10.3171/2015.5.peds15157
11/2015

Intracystic interferon-a treatment leads to neurotoxicity in craniopharyngioma: case report
Journal of Neurosurgery: Pediatrics
Julia Sharma, Christopher M. Bonfield, Ash Singhal, Juliette Hukin, Paul Steinbok
DOI: 10.3171/2015.2.peds14656
09/2015

Minimizing blood transfusions in the surgical correction of craniosynostosis: a 10-year single-center experience
Child's Nervous System
Christopher M. Bonfield, Julia Sharma, D. Douglas Cochrane, Ash Singhal, Paul Steinbok
DOI: 10.1007/s00381-015-2900-6
09/2015

Intraoperative ultrasound in pediatric brain tumors: does the surgeon get it right?
Child's Nervous System
Ash Singhal, A. Ross Hengel, Paul Steinbok, D. Doug Cochrane
DOI: 10.1007/s00381-015-2805-4
08/2015

Neurosurgery (Pediatric Neurosurgery)
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
MM Yang, A Singhal, N Au, AR Hengel
DOI: 10.1017/cjn.2015.217
05/2015

Evolution of a Pediatric Primary Cerebral ALK-1-Positive Anaplastic Large Cell Lymphoma on Serial MRI
Pediatric Neurosurgery
Mary J. Dunbar, Ash Singhal, Shahrad Rod Rassekh, Christopher Dunham
DOI: 10.1159/000380769
04/2015

Impact of preoperative laboratory investigation and blood cross-match on clinical management of pediatric neurosurgical patients
Child's Nervous System
Michael M. H. Yang, Ash Singhal, Nicholas Au, A. Ross Hengel
DOI: 10.1007/s00381-015-2617-6
02/2015

Central Nervous System Germ Cell Tumors (CNS-GCT)
Pediatric Neuro-oncology
Ute Bartels, Ash Singhal
DOI: 10.1007/978-1-4939-1541-5_14
2015

Video Diversion During Fundoscopic Examination in ChildrenA Randomized Controlled Trial
Journal of Child Neurology
Ash Singhal, Michael M.H. Yang, John M. Kerr
DOI: 10.1177/0883073813483363
07/2014

CSF complications following intradural spinal surgeries in children
Child's Nervous System
Victor Liu, Christopher Gillis, Doug Cochrane, Ash Singhal, Paul Steinbok
DOI: 10.1007/s00381-013-2276-4
09/2013

Neurological morbidity of surgical resection of pediatric cerebellar astrocytomas
Child's Nervous System
Paul Steinbok, Jaspreet Singh Mangat, John M. Kerr, Michael Sargent, Wihasto Suryaningtyas, Ashutosh Singhal, Doug Cochrane
DOI: 10.1007/s00381-013-2171-z
05/2013

Bilateral lambdoid and posterior sagittal craniosynostosis—management, evolution, and outcome
Child's Nervous System
Shibu Pillai, D. Cochrane, A. Singhal, Paul Steinbok
DOI: 10.1007/s00381-013-2155-z
05/2013

Ring Apophysis Fracture in Pediatric Lumbar Disc Herniation: A Common Entity
Pediatric Neurosurgery
Ash Singhal, Anish Mitra, Doug Cochrane, Paul Steinbok
DOI: 10.1159/000355127
2013

Improper use of child restraint seats as a sleeping environment: Two cases of childhood death
Paediatrics & Child Health
Ash Singhal, Elysia Adams, Ediriweera Desapriya
DOI: 10.1093/pch/17.9.498
11/2012

Does optic nerve sheath diameter on MRI decrease with clinically improved pediatric hydrocephalus?
Child's Nervous System
Ash Singhal, Michael M. H. Yang, Michael A. Sargent, D. Douglas Cochrane
DOI: 10.1007/s00381-012-1937-z
10/2012

Consensus definitions of complications for accurate recording and comparisons of surgical outcomes in pediatric neurosurgeryClinical article
Journal of Neurosurgery: Pediatrics
James M. Drake, Ash Singhal, Abhaya V. Kulkarni, Gabrielle DeVeber, D. Douglas Cochrane, The Canadian Pediatric Neurosurgery Study Group
DOI: 10.3171/2012.3.peds11233
08/2012

Endoscopic fenestration of cavum velum interpositum cysts: a case study of two symptomatic patients
Child's Nervous System
Calvin K. W. Tong, Ashutosh Singhal, D. Douglas Cochrane
DOI: 10.1007/s00381-012-1770-4
04/2012

Stridor at birth predicts poor outcome in neonates with myelomeningocele
Child's Nervous System
Eylem Ocal, Beverly Irwin, Douglas Cochrane, Ash Singhal, Paul Steinbok
DOI: 10.1007/s00381-011-1585-8
09/2011

Diffusion-weighted imaging and pathological correlation in pediatric medulloblastomas—“They are not always restricted!”
Child's Nervous System
Shibu Pillai, Ash Singhal, Angela T. Byrne, Chris Dunham, D. Douglas Cochrane, Paul Steinbok
DOI: 10.1007/s00381-011-1499-5
07/2011

Pediatric patients with poor neurological status and arteriovenous malformation hemorrhage: an outcome analysisClinical article
Journal of Neurosurgery: Pediatrics
Ash Singhal, Tara Adirim, Doug Cochrane, Paul Steinbok
DOI: 10.3171/2011.2.peds10355
05/2011

Trends in paediatric sport- and recreation-related injuries: An injury surveillance study at the British Columbia Children's Hospital (Vancouver, British Columbia) from 1992 to 2005
Paediatrics & Child Health
Kaivon Pakzad-Vaezi, Ash Singhal
DOI: 10.1093/pch/16.4.217
04/2011

Third ventricular shape: a predictor of endoscopic third ventriculostomy success in pediatric patientsClinical article
Journal of Neurosurgery: Pediatrics
Mansoor Foroughi, Andrew Wong, Paul Steinbok, Ash Singhal, Michael A. Sargent, D. Douglas Cochrane
DOI: 10.3171/2011.1.peds10461
04/2011

Natural history of untreated syringomyelia in pediatric patients
Neurosurgical Focus
Ash Singhal, Tim Bowen-Roberts, Paul Steinbok, Doug Cochrane, Angela T. Byrne, John M. Kerr
DOI: 10.3171/2011.9.focus11208
2011

Iatrogenic complications following shunting the subarachnoid space in infancy
Cerebrospinal Fluid Research
Douglas Cochrane, Ryan Janicki, Keith Aronyk, Jeff Pugh, Paul Steinbok, Ash Singhal
DOI: 10.1186/1743-8454-7-s1-s13
2010

Ventriculoperitoneal shunt after previous endoscopic third ventriculostomy: does ETV improve shunt survival?
Cerebrospinal Fluid Research
Ash Singhal, Tia Liu, Doug Cochrane, Paul Steinbok
DOI: 10.1186/1743-8454-7-s1-s14
2010

Supratentorial Primitive Neuroectodermal Tumors
Oncology of CNS Tumors
Ash Singhal, Shahid Gul, Paul Steinbok
DOI: 10.1007/978-3-642-02874-8_37
2010

Cingulate Lesions Presenting With Epileptic Spasms
Journal of Clinical Neurophysiology
Dewi Schrader, Lisa Langill, Ash Singhal, Paul Steinbok, Mary B. Connolly
DOI: 10.1097/wnp.0b013e3181baaacf
10/2009

Conventional and Diffusion-Weighted Magnetic Resonance Imaging Findings in a Pediatric Patient with a Posterior Fossa Brain Tumor and Papilledema
Pediatric Neurosurgery
Kaivon Pakzad-Vaezi, Doug Cochrane, Michael Sargent, Ash Singhal
DOI: 10.1159/000270156
2009

Optic nerve sheath fenestration and bilateral expansile cranioplasty for raised intracranial pressure in craniometaphyseal dysplasia: a case report
Child's Nervous System
Ash Singhal, David D. Cochrane
DOI: 10.1007/s00381-007-0549-5
01/2008

Long-term outcome of infants with positional occipital plagiocephaly
Child's Nervous System
Paul Steinbok, David Lam, Swati Singh, Patricia A. Mortenson, Ashutosh Singhal
DOI: 10.1007/s00381-007-0373-y
06/2007

Ascites and abdominal pseudocysts following ventriculoperitoneal shunt surgery: variations of the same theme
Journal of Neurosurgery: Pediatrics
Rajeev Kariyattil, Paul Steinbok, Ashutosh Singhal, D. Douglas Cochrane
DOI: 10.3171/ped.2007.106.5.350
05/2007

Early Hypodensity on Computed Tomographic Scan of the Brain in an Accidental Pediatric Head Injury
Neurosurgery
Paul Steinbok, Ashutosh Singhal, Ken Poskitt, D. Douglas Cochrane
DOI: 10.1227/01.neu.0000255398.00410.6b
04/2007

Gyriform Differentiation in Medulloblastoma – A Radiological Predictor of Histology
Pediatric Neurosurgery
Deepak Agrawal, Ashutosh Singhal, Glenda Hendson, Felix A. Durity
DOI: 10.1159/000098390
03/2007

Operative management of growing skull fractures: a technical note
Child's Nervous System
Ashutosh Singhal, Paul Steinbok
DOI: 10.1007/s00381-007-0552-x
2007

Complete Upward Migration of the Peritoneal End of a Ventriculoperitoneal Shunt into the Subgaleal Space
Pediatric Neurosurgery
Peter Y.C. Gan, Ash Singhal
DOI: 10.1159/000095575
10/2006

Near nerve local insulin prevents conduction slowing in experimental diabetes
Brain Research
Ash Singhal, Chu Cheng, Hong Sun, Douglas W Zochodne
DOI: 10.1016/s0006-8993(97)00412-5
07/1997

Research

Apolipoprotein E and Pediatric Traumatic Brain Injury: A Prospective Observational Study
Traumatic Brain Injury (TBI) is a particularly significant public health issue in children and adolescents, who account for over 50 per cent of new cases of head injury yearly. The causes for this are multi-factorial, but recent studies in adult TBI suggest that a genetic marker, the APOE gene, may play a role in influencing outcomes. We aim to determine if there is a relationship between subtypes of a gene encoding a lipoprotein, Apolipoprotein E, and outcome after pediatric TBI. Our hypothesis is that a genetic allelic subtype, APOE4, is associated with worse outcomes. Children with apparently similar demographic characteristics, mechanism of injury, and apparently similar clinical and radiographic injury patterns have notably different clinical outcomes.

BC Inflicted Childhood Neurotrauma Surveillance Project
The BC Inflicted Childhood Neurotrauma Surveillance Project is a part of Phase II of Preventing Shaken Baby Syndrome and Infant Abuse: The Period of PURPLE Crying Program. It is an active surveillance project that documents traumatic head injury in children less than two years of age.

The Program will be evaluated for its effectiveness in attaining the three primary goals of the intervention:

Attaining a “penetration” rate of 90-95 per cent of mothers of newborn infants
Reducing the incidence of shaken baby syndrome and/or infant abuse by 50 per cent
Achieving a cultural change in the understanding of early infant crying and its relationship to shaken baby syndrome
The surveillance system will also address the crucial need in B.C, for current knowledge of ICN incidence, as well as the challenges of measuring and implications for assessing prevention interventions. The first of its kind in Canada, this system will allow the establishment of a baseline incidence of ICN in B.C. Other objectives include determining the proportion of ICN versus non-inflicted neurotrauma and comparing the key characteristics of children with ICN to those with non-inflicted neurotrauma, and to the population at risk in the age group of 0-2 years old.

Analysis of Pediatric Injuries Related to Child Restraint Seats: Are Children at Higher Risk for Injury Outside the Vehicle Than Inside?
With the increasing popularity of hand-held child restraint seats (CRS), BC Children's Hospital clinicians have noticed an increase in injuries related to the improper use of CRS when used outside of the vehicle. These injuries include falls out of the CRS or falls of both the CRS and child. This potential public heath problem has not previously been studied.

We propose to study the problem on a national basis via coordinated data collection/retrieval in the pediatric trauma centers across the country. By examining pediatric trauma in cases in which a CRS was involved, we might identify what the national incidence and contributing factors of such injuries are. Furthermore, we also hope to determine the anatomical pattern of injury associated with CRS injuries, particularly when associated with improper use of the seat outside the vehicle.

Honours & Awards

Ontario Graduate Scholarship in Science and Techn. Research Award – University of Toronto, 2001

Critical Care Research Award – Canadian Congress of Neurological Sciences, 2003