Overview

Dr. Singhal is involved and interested in a multitude of pediatric neurosurgery topics, however his main interests are head injuries and their causes, consequences and interactions with the environment. His research employs leading-edge imaging technologies as well as the study of potentially underlying environmental and genomic factors that may contribute to disease progression and outcome. Another major research focus is the monitoring and study of post-operative status, management and outcome of neurosurgery patients.

Publications

Global trends and decision-making in the management of arachnoid cysts
Child's Nervous System
DOI: 10.1007/s00381-023-06212-8
2024

Intraoperative Ultrasound in Endoscopic Sagittal Suture Synostosis to Optimize Incision Planning and Avoid Misdiagnosis
Journal of Craniofacial Surgery
DOI: 10.1097/SCS.0000000000010560
2024

A re-evaluation of the Endoscopic Third Ventriculostomy Success Score: a Hydrocephalus Clinical Research Network study
Journal of Neurosurgery: Pediatrics
DOI: 10.3171/2023.12.PEDS23401
2024

Optic nerve sheath diameter correlates with both success and failure of hydrocephalus treatment in pediatric patients with pineal region lesions
Acta Neurochirurgica
DOI: 10.1007/s00701-024-06122-x
2024

Patient-Reported Outcome Measures More Than Fifteen Years After Treatment of Sagittal or Metopic Craniosynostosis: A Prospective Cohort Study
Research Square
DOI: 10.21203/rs.3.rs-3296264/v1
2023

Treatment of hydrocephalus following posterior fossa tumor resection: a multicenter collaboration from the Hydrocephalus Clinical Research Network
Journal of Neuro-Oncology
DOI: 10.1007/s11060-023-04316-4
2023

Outcomes of a radiation sparing approach in medulloblastoma by subgroup in young children: an institutional review
Child's Nervous System
DOI: 10.1007/s00381-023-05918-z
2023

Cosmetic satisfaction and patient-reported outcomes following surgical treatment of single-suture craniosynostosis: a systematic review
Child's Nervous System
DOI: 10.1007/s00381-023-06063-3
2023

Added value of corpus callosotomy following vagus nerve stimulation in children with Lennox–Gastaut syndrome: A multicenter, multinational study
Epilepsia
DOI: 10.1111/epi.17796
2023

A qualitative study of transitioning patients with hydrocephalus from pediatric to adult care: fear of uncertainty, communication gaps, independence, and loss of relationships
Journal of Neurosurgery: Pediatrics
DOI: 10.3171/2022.2.PEDS21419
2022

Treatment-responsive Holmes tremor in a child with low-pressure hydrocephalus: video case report and systematic review of the literature
Journal of Neurosurgery: Pediatrics
Chang, S.J. and Mitchell, R. and Hukin, J. and Singhal, A.
DOI: 10.3171/2021.12.PEDS21539
2022

Acetazolamide to treat symptomatic ruptured arachnoid cysts: illustrative cases
Journal of Neurosurgery: Case Lessons
DOI: 10.3171/CASE21462
2022

Endoscopic third ventriculostomy revision after failure of initial endoscopic third ventriculostomy and choroid plexus cauterization
Journal of Neurosurgery: Pediatrics
DOI: 10.3171/2022.3.PEDS224
2022

A case series of pediatric survivors of anaplastic pleomorphic xanthoastrocytoma
Neuro-Oncology Advances
Rebecca Ronsley and Christopher Dunham and Stephen Yip and Lindsay Brown and Jeffrey A Zuccato and Shirin Karimi and Gelareh Zadeh and Karen Goddard and Ash Singhal and Juliette Hukin and Sylvia Cheng
DOI: 10.1093/noajnl/vdaa176
01/2021

Cerebellar mutism after posterior fossa tumor resection in children: a multicenter international retrospective study to determine possible modifiable factors
Child's Nervous System
Renne, B. and Radic, J. and Agrawal, D. and Albrecht, B. and Bonfield, C.M. and Cohrs, G. and Davis, T. and Gupta, A. and Hebb, A.L.O. and Lamberti-Pasculli, M. and Knerlich-Lukoschus, F. and Lindsay, S. and McNeely, P.D. and Pillai, S. and Rai, H.I.S. and Sborov, K.D. and Vitali, A. and Walling, S. and Woerdeman, P. and Suryaningtyas, W. and Cochrane, D. and Singhal, A. and Steinbok, P.
DOI: 10.1007/s00381-019-04058-7
2020

Systematic review of spinal deformities following multi-level selective dorsal rhizotomy
Child's Nervous System
Wheelwright, M. and Selvey, P.J. and Steinbok, P. and Singhal, A. and Ibrahim, G. and Fallah, A. and Weil, A.G. and Halvorson, K. and Tu, A.
DOI: 10.1007/s00381-019-04375-x
2020

Cranioplasties following craniectomies in children—a multicenter, retrospective cohort study
Child's Nervous System
Klieverik, V.M. and Miller, K.J. and Han, K.S. and Singhal, A. and Vassilyadi, M. and Touchette, C.J. and Weil, A.G. and Woerdeman, P.A.
DOI: 10.1007/s00381-018-4024-2
2019

Cranioplasty after craniectomy in pediatric patients—a systematic review
Child's Nervous System
Klieverik, V.M. and Miller, K.J. and Singhal, A. and Han, K.S. and Woerdeman, P.A.
DOI: 10.1007/s00381-018-4025-1
2019

An Educational Video Improves Consent in Pediatric Lumbar Puncture: A Randomized Control Trial
Pediatric Neurology
Dunbar, M. and Paton, G. and Singhal, A.
DOI: 10.1016/j.pediatrneurol.2019.04.014
2019

The Preferred Attributes of a Trauma Team Leader: Evidence From a Discrete Choice Experiment
Journal of Surgical Education
Mo, D. and O'Hara, N.N. and Hengel, R. and Cheong, A.R. and Singhal, A.
DOI: 10.1016/j.jsurg.2018.06.021
2019

Outcomes and complications for individual neurosurgeons for the treatment of Chiari I malformation at a children’s hospital
Child's Nervous System
Walker-Palmer, T.-K. and Cochrane, D.D. and Singhal, A. and Steinbok, P.
DOI: 10.1007/s00381-019-04201-4
2019

What attributes define excellence in a trauma team? A qualitative study
Canadian Journal of Surgery
Kassam, F. and Cheong, A.R. and Evans, D. and Singhal, A.
DOI: 10.1503/cjs.012416
2019

Impact of work hours and sleep on well-being and burnout for physicians-in-training: the Resident Activity Tracker Evaluation Study
Medical Education
Mendelsohn, D. and Despot, I. and Gooderham, P.A. and Singhal, A. and Redekop, G.J. and Toyota, B.D.
DOI: 10.1111/medu.13757
2019

Examining the need for routine intensive care admission after surgical repair of nonsyndromic craniosynostosis: A preliminary analysis
Journal of Neurosurgery: Pediatrics
Bonfield, C.M. and Basem, J. and Cochrane, D.D. and Singhal, A. and Steinbok, P.
DOI: 10.3171/2018.6.PEDS18136
2018

International survey on the management of Chiari 1 malformation and syringomyelia: evolving worldwide opinions
Child's Nervous System
Singhal, A. and Cheong, A. and Steinbok, P.
DOI: 10.1007/s00381-018-3741-x
2018

MRI in mild pediatric traumatic brain injury: Diagnostic overkill or useful tool?
Child's Nervous System
Cohrs, G. and Huhndorf, M. and Niemczyk, N. and Volz, L.J. and Bernsmeier, A. and Singhal, A. and Larsen, N. and Synowitz, M. and Knerlich-Lukoschus, F.
DOI: 10.1007/s00381-018-3771-4
2018

Bobble-head doll syndrome: Report of 2 cases and a review of the literature, with video documentation of the clinical phenomenon
Journal of Neurosurgery: Pediatrics
Renne, B. and Rueckriegel, S. and Ramachandran, S. and Radic, J. and Steinbok, P. and Singhal, A.
DOI: 10.3171/2017.9.PEDS16704
2018

Eight-year outcome of implementation of abusive head trauma prevention
Child Abuse and Neglect
Barr, R.G. and Barr, M. and Rajabali, F. and Humphreys, C. and Pike, I. and Brant, R. and Hlady, J. and Colbourne, M. and Fujiwara, T. and Singhal, A.
DOI: 10.1016/j.chiabu.2018.07.004
2018

Video Diversion Improves Success Rate of Fundoscopic Examination in Children: A Prospective Randomized Controlled Trial
Pediatric Neurology
Yang, M.M.H. and Singhal, A. and Hengel, A.R. and Kerr, J.M. and St-Pierre, G.H. and George, S. and Muir, K. and Thiessen, P. and Enarson, P.
DOI: 10.1016/j.pediatrneurol.2017.09.008
2018

Challenges in minor TBI and indications for head CT in pediatric TBI—an update
Child's Nervous System
Singh, N. and Singhal, A.
DOI: 10.1007/s00381-017-3535-6
2017

Correction to: Challenges in minor TBI and indications for head CT in pediatric TBI—an update (Childs Nerv Syst, (2017), 33,(1677–1681), 10.1007/s00381-017-3535-6)
Child's Nervous System
Singh, N. and Singhal, A.
DOI: 10.1007/s00381-017-3608-6
2017

State of global pediatric neurosurgery outreach: Survey by the International Education Subcommittee
Journal of Neurosurgery: Pediatrics
Davis, M.C. and Rocque, B.G. and Singhal, A. and Ridder, T. and Pattisapu, J.V. and Johnston, J.M.
DOI: 10.3171/2017.3.PEDS16433
2017

Manifestations of Tuberous Sclerosis Complex: The Experience of a Provincial Clinic
Canadian Journal of Neurological Sciences
Wilbur, C. and Sanguansermsri, C. and Chable, H. and Anghelina, M. and Peinhof, S. and Anderson, K. and Steinbok, P. and Singhal, A. and Datta, A. and Connolly, M.B.
DOI: 10.1017/cjn.2016.311
2017

Impact of early follow-up intervention on parent-reported postconcussion pediatric symptoms: A feasibility study
Journal of Head Trauma Rehabilitation
Mortenson, P. and Singhal, A. and Hengel, A.R. and Purtzki, J.
DOI: 10.1097/HTR.0000000000000223
2016

Regression of ventriculomegaly following medical management of a patient with Hurler syndrome
Journal of Neurosurgery: Pediatrics
Liang, J. and Singhal, A.
DOI: 10.3171/2015.9.PEDS15477
2016

Establishing MRI in the acute pediatric mild traumatic brain injury setting
German Medical Science GMS Publishing House
DOI: 10.3205/16DGNC433
2016

Minimizing blood transfusions in the surgical correction of craniosynostosis: a 10-year single-center experience
Child's Nervous System
Bonfield, C.M. and Sharma, J. and Cochrane, D.D. and Singhal, A. and Steinbok, P.
DOI: 10.1007/s00381-015-2900-6
2016

Neurosurgery (Pediatric Neurosurgery)
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
MM Yang and A Singhal and N Au and AR Hengel
DOI: 10.1017/cjn.2015.217
05/2015

Intraoperative ultrasound in pediatric brain tumors: does the surgeon get it right?
Child's Nervous System
Singhal, A. and Ross Hengel, A. and Steinbok, P. and Doug Cochrane, D.
DOI: 10.1007/s00381-015-2805-4
2015

Intracystic interferon-a treatment leads to neurotoxicity in craniopharyngioma: Case report
Journal of Neurosurgery: Pediatrics
Sharma, J. and Bonfield, C.M. and Singhal, A. and Hukin, J. and Steinbok, P.
DOI: 10.3171/2015.2.PEDS14656
2015

Hypothermia for traumatic brain injury in children - A Phase II randomized controlled trial
Critical Care Medicine
Beca, J. and Mcsharry, B. and Erickson, S. and Yung, M. and Schibler, A. and Slater, A. and Wilkins, B. and Singhal, A. and Williams, G. and Sherring, C. and Butt, W.
DOI: 10.1097/CCM.0000000000000947
2015

Evolution of a Pediatric Primary Cerebral ALK-1-Positive Anaplastic Large Cell Lymphoma on Serial MRI
Pediatric Neurosurgery
Dunbar, M.J. and Singhal, A. and Rassekh, S.R. and Dunham, C.
DOI: 10.1159/000380769
2015

Central nervous system germ cell tumors (CNS-GCT)
Pediatric Neuro-oncology
DOI: 10.1007/978-1-4939-1541-5
2015

The role of resection alone in select children with intracranial ependymoma: the Canadian Pediatric Brain Tumour Consortium experience
Child's Nervous System
Ailon, T. and Dunham, C. and Carret, A.-S. and Tabori, U. and Mcneely, P.D. and Zelcer, S. and Wilson, B. and Lafay-Cousin, L. and Johnston, D. and Eisenstat, D.D. and Silva, M. and Jabado, N. and Goddard, K.J. and Fryer, C. and Hendson, G. and Hawkins, C. and Dunn, S. and Yip, S. and Singhal, A. and Hukin, J.
DOI: 10.1007/s00381-014-2575-4
2015

Preoperative ultrasound localization of the lambda in patients with scaphocephaly: A technical note for minimally invasive craniectomy
Journal of Neurosurgery: Pediatrics
Bonfield, C.M. and Cochrane, D.D. and Singhal, A. and Steinbok, P.
DOI: 10.3171/2015.5.PEDS15157
2015

Impact of preoperative laboratory investigation and blood cross-match on clinical management of pediatric neurosurgical patients
Child's Nervous System
Yang, M.M.H. and Singhal, A. and Au, N. and Hengel, A.R.
DOI: 10.1007/s00381-015-2617-6
2015

CSF complications following intradural spinal surgeries in children
Child's Nervous System
Liu, V. and Gillis, C. and Cochrane, D. and Singhal, A. and Steinbok, P.
DOI: 10.1007/s00381-013-2276-4
2014

Video diversion during fundoscopic examination in children: A randomized controlled trial
Journal of Child Neurology
Singhal, A. and Yang, M.M.H. and Kerr, J.M.
DOI: 10.1177/0883073813483363
2014

Traumatic brain injury and critical care management in the pediatric population
Neurosurgery Knowledge Update (Harbaugh eds)
2014

Neurointensive Care for Head Injuries
Pediatric Neurosurgery Tricks of the Trade (Cohen, A. eds)
2014

Neurological morbidity of surgical resection of pediatric cerebellar astrocytomas
Child's Nervous System
Steinbok, P. and Mangat, J.S. and Kerr, J.M. and Sargent, M. and Suryaningtyas, W. and Singhal, A. and Cochrane, D.
DOI: 10.1007/s00381-013-2171-z
2013

Does optic nerve sheath diameter on MRI decrease with clinically improved pediatric hydrocephalus?
Child's Nervous System
Singhal, A. and Yang, M.M.H. and Sargent, M.A. and Cochrane, D.D.
DOI: 10.1007/s00381-012-1937-z
2013

Ring apophysis fracture in pediatric lumbar disc herniation: A common entity
Pediatric Neurosurgery
Singhal, A. and Mitra, A. and Cochrane, D. and Steinbok, P.
DOI: 10.1159/000355127
2013

Bilateral lambdoid and posterior sagittal craniosynostosis - Management, evolution, and outcome
Child's Nervous System
Pillai, S. and Cochrane, D. and Singhal, A. and Steinbok, P.
DOI: 10.1007/s00381-013-2155-z
2013

Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children
Cancer Research
Triscott, J. and Lee, C. and Foster, C. and Manoranjan, B. and Pambid, M.R. and Berns, R. and Fotovati, A. and Venugopal, C. and O'Halloran, K. and Narendran, A. and Hawkins, C. and Ramaswamy, V. and Bouffet, E. and Taylor, M.D. and Singhal, A. and Hukin, J. and Rassekh, R. and Yip, S. and Northcott, P. and Singh, S.K. and Dunham, C. and Dunn, S.E.
DOI: 10.1158/0008-5472.CAN-12-4331
2013

Stridor at birth predicts poor outcome in neonates with myelomeningocele
Child's Nervous System
Ocal, E. and Irwin, B. and Cochrane, D. and Singhal, A. and Steinbok, P.
DOI: 10.1007/s00381-011-1585-8
2012

Possible differentiation of cerebral glioblastoma into pleomorphic xanthoastrocytoma: An unusual case in an infant - Case report
Journal of Neurosurgery: Pediatrics
Yang, M.M.H. and Singhal, A. and Rassekh, S.R. and Yip, S. and Eydoux, P. and Dunham, C.
DOI: 10.3171/2012.1.PEDS11326
2012

Endoscopic fenestration of cavum velum interpositum cysts: A case study of two symptomatic patients
Child's Nervous System
Tong, C.K.W. and Singhal, A. and Cochrane, D.D.
DOI: 10.1007/s00381-012-1770-4
2012

Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice
Stem Cells
Lee, C. and Fotovati, A. and Triscott, J. and Chen, J. and Venugopal, C. and Singhal, A. and Dunham, C. and Kerr, J.M. and Verreault, M. and Yip, S. and Wakimoto, H. and Jones, C. and Jayanthan, A. and Narendran, A. and Singh, S.K. and Dunn, S.E.
DOI: 10.1002/stem.1081
2012

Improper use of child restraint seats as a sleeping environment: Two cases of childhood death
Paediatrics and Child Health (Canada)
Singhal, A. and Adams, E. and Desapriya, E.
DOI: 10.1093/pch/17.9.498
2012

Consensus definitions of complications for accurate recording and comparisons of surgical outcomes in pediatric neurosurgery: Clinical article
Journal of Neurosurgery: Pediatrics
Drake, J.M. and Singhal, A. and Kulkarni, A.V. and DeVeber, G. and Cochrane, D.D.
DOI: 10.3171/2012.3.PEDS11233
2012

Pediatric patients with poor neurological status and arteriovenous malformation hemorrhage: An outcome analysis: Clinical article
Journal of Neurosurgery: Pediatrics
Singhal, A. and Adirim, T. and Cochrane, D. and Steinbok, P.
DOI: 10.3171/2011.2.PEDS10355
2011

Trends in paediatric sport- and recreation-related injuries: An injury surveillance study at the British Columbia Children's Hospital (Vancouver, British Columbia) from 1992 to 2005
Paediatrics and Child Health
Pakzad-Vaezi, K. and Singhal, A.
DOI: 10.1093/pch/16.4.217
2011

Third ventricular shape: A predictor of endoscopic third ventriculostomy success in pediatric patients. Clinical article
Journal of Neurosurgery: Pediatrics
Foroughi, M. and Wong, A. and Steinbok, P. and Singhal, A.S.H. and Sargent, M.A. and Cochrane, D.D.
DOI: 10.3171/2011.1.PEDS10461
2011

Natural history of untreated syringomyelia in pediatric patients
Neurosurgical Focus
Singhal, A. and Bowen-Roberts, T. and Steinbok, P. and Cochrane, D. and Byrne, A.T. and Kerr, J.M.
DOI: 10.3171/2011.9.FOCUS11208
2011

Diffusion-weighted imaging and pathological correlation in pediatric medulloblastomas-They are not always restricted!
Child's Nervous System
Pillai, S. and Singhal, A. and Byrne, A.T. and Dunham, C. and Douglas Cochrane, D. and Steinbok, P.
DOI: 10.1007/s00381-011-1499-5
2011

Genetic-environmental interaction in a unique case of Muenke syndrome with intracranial hypertension
Child's Nervous System
Agochukwu, N.B. and Solomon, B.D. and Zajaczkowska-Kielska, A. and Lyons, C.J. and Pollock, T. and Singhal, A. and Van Allen, M.I. and Muenke, M.
DOI: 10.1007/s00381-011-1595-6
2011

Trauma association of canada pediatric subcommittee National pediatric cervical spine evaluation pathway: Consensus guidelines
Journal of Trauma - Injury, Infection and Critical Care
Chung, S. and Mikrogianakis, A. and Wales, P.W. and Dirks, P. and Shroff, M. and Singhal, A. and Grant, V. and Hancock, B.J. and Creery, D. and Atkinson, J. and St-Vil, D. and Crevier, L. and Yanchar, N. and Hayashi, A. and Mehta, V. and Carey, T. and Dhanani, S. and Siemens, R. and Singh, S. and Price, D.
DOI: 10.1097/TA.0b013e3182108823
2011

Conventional and diffusion-weighted magnetic resonance imaging findings in a pediatric patient with a posterior fossa brain tumor and papilledema
Pediatric Neurosurgery
Pakzad-Vaezi, K. and Cochrane, D. and Sargent, M. and Singhal, A.
DOI: 10.1159/000270156
2010

Iatrogenic complications following shunting the subarachnoid space in infancy
Cerebrospinal Fluid Research
Douglas Cochrane and Ryan Janicki and Keith Aronyk and Jeff Pugh and Paul Steinbok and Ash Singhal
DOI: 10.1186/1743-8454-7-s1-s13
2010

Ventriculoperitoneal shunt after previous endoscopic third ventriculostomy: does ETV improve shunt survival?
Cerebrospinal Fluid Research
Ash Singhal and Tia Liu and Doug Cochrane and Paul Steinbok
DOI: 10.1186/1743-8454-7-s1-s14
2010

Supratentorial primitive neuroectodermal tumors
Oncology of CNS Tumors
DOI: 10.1007/978-3-642-02874-8_37
2010

Intracranial hypertension secondary to sigmoid sinus compression by group A streptococcal epidural abscess
Journal of Laryngology and Otology
Ludemann, J.P. and Poskitt, K. and Singhal, A.
DOI: 10.1017/S0022215109990764
2010

Cingulate lesions presenting with epileptic spasms
Journal of Clinical Neurophysiology
Schrader, D. and Langill, L. and Singhal, A. and Steinbok, P. and Connolly, M.B.
DOI: 10.1097/WNP.0b013e3181baaacf
2009

Optic nerve sheath fenestration and bilateral expansile cranioplasty for raised intracranial pressure in craniometaphyseal dysplasia: A case report
Child's Nervous System
Singhal, A. and Cochrane, D.D.
DOI: 10.1007/s00381-007-0549-5
2008

Operative management of growing skull fractures: A technical note
Child's Nervous System
Singhal, A. and Steinbok, P.
DOI: 10.1007/s00381-007-0552-x
2008

Cerebrospinal fluid (CSF) leak and pseudomeningocele formation after posterior fossa tumor resection in children: A retrospective analysis
Child's Nervous System
Steinbok, P. and Singhal, A. and Mills, J. and Cochrane, D.D. and Price, A.V.
DOI: 10.1007/s00381-006-0234-0
2007

Ascites and abdominal pseudocysts following ventriculoperitoneal shunt surgery: Variations of the same theme
Journal of Neurosurgery
Kariyattil, R. and Steinbok, P. and Singhal, A. and Cochrane, D.D.
DOI: 10.3171/ped.2007.106.5.350
2007

Long-term outcome of infants with positional occipital plagiocephaly
Child's Nervous System
Steinbok, P. and Lam, D. and Singh, S. and Mortenson, P.A. and Singhal, A.
DOI: 10.1007/s00381-007-0373-y
2007

Early hypodensity on computed tomographic scan of the brain in an accidental pediatric head injury
Neurosurgery
Steinbok, P. and Singhal, A. and Poskitt, K. and Cochrane, D.D.
DOI: 10.1227/01.NEU.0000255398.00410.6B
2007

Analysis of paediatric injuries related to child restraint seats: Are children at higher risk of injury outside the vehicle than inside?
International Journal of Injury Control and Safety Promotion
Desapriya, E.B.R. and Pike, I. and Singhal, A.
DOI: 10.1080/17457300701577252
2007

Gyriform differentiation in medulloblastoma - A radiological predictor of histology
Pediatric Neurosurgery
Agrawal, D. and Singhal, A. and Hendson, G. and Durity, F.A.
DOI: 10.1159/000098390
2007

Complete upward migration of the peritoneal end of a ventriculoperitoneal shunt into the subgaleal space
Pediatric Neurosurgery
Gan, P.Y.C. and Singhal, A.
DOI: 10.1159/000095575
2006

Scalp Ulceration From a Circumferential Head Dressing After Craniotomy: Case Report of An Uncommon Complication Due to Human Error
Canadian Journal of Plastic Surgery
Ashutosh Singhal and Peter W Bray and Mark Bernstein
DOI: 10.1177/229255030401200408
2004

Surgical Management of Spinal Metastatic Disease
Youmans Neurological Surgery, 5th edition (Winn, H.R. eds)
2004

Trauma recidivism in a large urban Canadian population
Journal of Trauma - Injury, Infection and Critical Care
Caufeild, J. and Singhal, A. and Moulton, R. and Brenneman, F. and Redelmeier, D. and Baker, A.J.
DOI: 10.1097/01.TA.0000135350.06670.60
2004

Neuroendoscopic basket dilation technique for the fenestration of the ventricular wall or intracranial cysts - Technical note: Commentary
Neurologia Medico-Chirurgica
Arai, H. and Miyajima, M. and Singhal, A. and Rutka, J.T.
2004

An Acute CNS Inflammatory Response Correlates with Outcome in Human Traumatic Brain Injury
Journal of Neurotrauma
08/2002

Association between cerebrospinal fluid interleukin-6 concentrations and outcome after severe human traumatic brain injury
Journal of Neurotrauma
Singhal, A. and Baker, A.J. and Hare, G.M.T. and Reinders, F.X. and Schlichter, L.C. and Moulton, R.J.
DOI: 10.1089/089771502320317087
2002

Intensive Care Unit Management of Spinal Cord Injury
Intensive Care in Neurosurgery (Andrews, B, eds)
2002

Outpatient lumbar microdiscectomy: A prospective study in 122 patients
Canadian Journal of Neurological Sciences
Singhal, A. and Bernstein, M.
DOI: 10.1017/S031716710000202X
2002

Near nerve local insulin prevents conduction slowing in experimental diabetes
Brain Research
Ash Singhal and Chu Cheng and Hong Sun and Douglas W Zochodne
DOI: 10.1016/s0006-8993(97)00412-5
07/1997

Possible Trophic Actions of Near-Nerve Insulin in Diabetic and Nondiabetic Rats
Neurology
1996

Research

Apolipoprotein E and Pediatric Traumatic Brain Injury: A Prospective Observational Study
Traumatic Brain Injury (TBI) is a particularly significant public health issue in children and adolescents, who account for over 50 per cent of new cases of head injury yearly. The causes for this are multi-factorial, but recent studies in adult TBI suggest that a genetic marker, the APOE gene, may play a role in influencing outcomes. We aim to determine if there is a relationship between subtypes of a gene encoding a lipoprotein, Apolipoprotein E, and outcome after pediatric TBI. Our hypothesis is that a genetic allelic subtype, APOE4, is associated with worse outcomes. Children with apparently similar demographic characteristics, mechanism of injury, and apparently similar clinical and radiographic injury patterns have notably different clinical outcomes.

BC Inflicted Childhood Neurotrauma Surveillance Project
The BC Inflicted Childhood Neurotrauma Surveillance Project is a part of Phase II of Preventing Shaken Baby Syndrome and Infant Abuse: The Period of PURPLE Crying Program. It is an active surveillance project that documents traumatic head injury in children less than two years of age.

The Program will be evaluated for its effectiveness in attaining the three primary goals of the intervention:

Attaining a “penetration” rate of 90-95 per cent of mothers of newborn infants
Reducing the incidence of shaken baby syndrome and/or infant abuse by 50 per cent
Achieving a cultural change in the understanding of early infant crying and its relationship to shaken baby syndrome
The surveillance system will also address the crucial need in B.C, for current knowledge of ICN incidence, as well as the challenges of measuring and implications for assessing prevention interventions. The first of its kind in Canada, this system will allow the establishment of a baseline incidence of ICN in B.C. Other objectives include determining the proportion of ICN versus non-inflicted neurotrauma and comparing the key characteristics of children with ICN to those with non-inflicted neurotrauma, and to the population at risk in the age group of 0-2 years old.

Analysis of Pediatric Injuries Related to Child Restraint Seats: Are Children at Higher Risk for Injury Outside the Vehicle Than Inside?
With the increasing popularity of hand-held child restraint seats (CRS), BC Children's Hospital clinicians have noticed an increase in injuries related to the improper use of CRS when used outside of the vehicle. These injuries include falls out of the CRS or falls of both the CRS and child. This potential public heath problem has not previously been studied.

We propose to study the problem on a national basis via coordinated data collection/retrieval in the pediatric trauma centers across the country. By examining pediatric trauma in cases in which a CRS was involved, we might identify what the national incidence and contributing factors of such injuries are. Furthermore, we also hope to determine the anatomical pattern of injury associated with CRS injuries, particularly when associated with improper use of the seat outside the vehicle.

Honours & Awards

Ontario Graduate Scholarship in Science and Techn. Research Award – University of Toronto, 2001

Critical Care Research Award – Canadian Congress of Neurological Sciences, 2003

Research Group Members

Caitlin Adams, Summer Undergraduate Student
Hanan Algethami, Fellow
Madeline Elder, Summer Student
Daniella Linde, Summer Student
Hana Miller, Summer Student
Vesna Popovska, Research Director, Pediatric Neurology & Neurosurgery
Annika Weir, Research Coordinator