- Overview
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My research interests are in the area of clinical neuropsychology, with a focus on memory, working memory, and executive functions. The following is a summary of my recent work:
My work in multiple sclerosis (MS) addresses controversies regarding the nature of MS-associated cognitive impairment. The research has contributed to deconstructing the popular retrieval-based account of memory dysfunction. Furthermore, previously unrecognized clinical features of MS that are associated with memory dysfunction have been elucidated.
I have an ongoing interest in the neurocognitive features of schizophrenia. This work is designed to elucidate the nature of memory impairment in schizophrenia and associations between illness-related factors and cognition.
I have strong interests in concussion and traumatic brain injury. This work is focused on determining who is at greatest risk for poor cognitive outcome following concussion. This research also evaluates the relationship between the extent of concussion exposure (single and multiple injuries) and neurocognitive impairment. Theoretically, these issues are important in understanding brain reserve capacity and threshold concepts in neuropsychology.
- Publications
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Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer’s disease
Acta Neuropathologica
DOI: 10.1007/s00401-016-1647-9
2017Effects of exercise on serum triglycerides and symptoms of schizophrenia
Journal of Clinical Psychopharmacology
DOI: 10.1097/JCP.0000000000000648
2017Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users
Addiction Biology
DOI: 10.1111/adb.12363
2017Structural brain markers are differentially associated with neurocognitive profiles in socially marginalized people with multimorbid illness
Neuropsychology
DOI: 10.1037/neu0000304
2017A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence
Psychopharmacology
DOI: 10.1007/s00213-017-4551-7
2017The Positive and Negative Syndrome Scale (PANSS): A Three-Factor Model of Psychopathology in Marginally Housed Persons with Substance Dependence and Psychiatric Illness
PLOS ONE
Chantelle J. Giesbrecht and Norm O’Rourke and Olga Leonova and Verena Strehlau and Karine Paquet and Fidel Vila-Rodriguez and William J. Panenka and G. William MacEwan and Geoffrey N. Smith and Allen E. Thornton and William G. Honer
DOI: 10.1371/journal.pone.0151648
03/2016Inhibitory control underlies individual differences in older adults’ hindsight bias.
Psychology and Aging
Alisha Coolin and Edgar Erdfelder and Daniel M. Bernstein and Allen E. Thornton and Wendy Loken Thornton
DOI: 10.1037/pag0000088
2016Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence
Psychiatry Research
DOI: 10.1016/j.psychres.2016.04.059
2016Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users
Schizophrenia Research
DOI: 10.1016/j.schres.2016.08.001
2016Visual working memory deterioration preceding relapse in psychosis
Psychological Medicine
DOI: 10.1017/S0033291716000751
2016Cortical morphology and early adverse birth events in men with first-episode psychosis
Psychological Medicine
DOI: 10.1017/S003329171400292X
2015Mortality from treatable illnesses in marginally housed adults: A prospective cohort study
BMJ Open
DOI: 10.1136/bmjopen-2015-008876
2015Cognition and plasma ratio of clozapine to N-desmethylclozapine in patients with clozapine-resistant schizophrenia
American Journal of Psychiatry
DOI: 10.1176/appi.ajp.2015.15070899
2015Explaining individual differences in cognitive processes underlying hindsight bias
Psychonomic Bulletin & Review
Alisha Coolin and Edgar Erdfelder and Daniel M. Bernstein and Allen E. Thornton and Wendy Loken Thornton
DOI: 10.3758/s13423-014-0691-5
08/2014Age Differences in Hindsight Bias: The Role of Episodic Memory and Inhibition
Experimental Aging Research
Alisha Coolin and Daniel M. Bernstein and Allen E. Thornton and Wendy Loken Thornton
DOI: 10.1080/0361073x.2014.896667
04/2014UNDERSTANDING OF MUSICAL IMPAIRMENT MAY FACILITATE THE DEVELOPMENT OF INSIGHT FOR COGNITIVE REMEDIATION
Schizophrenia Research
Ken Sawada and Sanae Hatada and Allen E. Thornton and William G. Honer
DOI: 10.1016/s0920-9964(14)70087-8
04/201448 echo T
2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination
NeuroImage: Clinical
DOI: 10.1016/j.nicl.2014.10.006
2014Neurocognitive profiles of marginally housed persons with comorbid substance dependence, viral infection, and psychiatric illness
Journal of Clinical and Experimental Neuropsychology
DOI: 10.1080/13803395.2014.963519
2014Impaired musical ability in people with schizophrenia
Journal of Psychiatry and Neuroscience
DOI: 10.1503/jpn.120207
2014Select neurocognitive impairment in HIV-infected women: Associations with HIV viral load, hepatitis C virus, and depression, but not leukocyte telomere length
PLoS ONE
DOI: 10.1371/journal.pone.0089556
2014Age differences in hindsight bias: The role of episodic memory and inhibition
Experimental Aging Research
DOI: 10.1080/0361073X.2014.896667
2014Personalized risk assessment of drug-related harm is associated with health outcomes
PLoS ONE
DOI: 10.1371/journal.pone.0079754
2013Effects of eight weeks of atypical antipsychotic treatment on middle frontal thickness in drug-naïve first-episode psychosis patients
Schizophrenia Research
DOI: 10.1016/j.schres.2013.06.025
2013Cognitive-behavioral prevention of postconcussion syndrome in at-risk patients: A pilot randomized controlled trial
Journal of Head Trauma Rehabilitation
DOI: 10.1097/HTR.0b013e3182915cb5
2013Relationships among depression, PTSD, methamphetamine abuse, and psychosis
Journal of Dual Diagnosis
DOI: 10.1080/15504263.2013.778930
2013The hotel study: Multimorbidity in a community sample living in marginal housing
American Journal of Psychiatry
DOI: 10.1176/appi.ajp.2013.12111439
2013Predictors of persistent psychotic symptoms in persons with methamphetamine abuse receiving psychiatric treatment
Journal of Nervous and Mental Disease
DOI: 10.1097/NMD.0000000000000059
2013A quantitative review of the profile and time course of symptom change in schizophrenia treated with clozapine
Journal of Psychopharmacology
Megan Sherwood and Allen E Thornton and William G Honer
DOI: 10.1177/0269881112440513
09/2012Antipsychotic medications: Linking receptor antagonism to neuropsychological functioning in first episode psychosis
Journal of the International Neuropsychological Society
DOI: 10.1017/S1355617712000343
2012Hippocampal volume and the brain-derived neurotrophic factor Val66Met polymorphism in first episode psychosis
Schizophrenia Research
DOI: 10.1016/j.schres.2011.11.022
2012Cognitive reserve, presynaptic proteins and dementia in the elderly
Translational Psychiatry
DOI: 10.1038/tp.2012.38
2012The assessment of symptom severity and functional impairment with DSM-IV axis V
Psychiatric Services
DOI: 10.1176/appi.ps.62.4.411
2011The ecological validity of everyday cognition in hospitalized patients with serious mental illness
Journal of Clinical and Experimental Neuropsychology
Allen E. Thornton and Hayley Kristinsson and Vanessa G. DeFreitas and Wendy Loken Thornton
DOI: 10.1080/13803390903002209
02/2010Hippocampal plasticity in response to exercise in schizophrenia
Archives of General Psychiatry
DOI: 10.1001/archgenpsychiatry.2009.193
2010Profiles of individuals seeking psychiatric help for psychotic symptoms linked to methamphetamine abuse - Baseline results from the MAPS (methamphetamine and psychosis study)
Mental Health and Substance Use: Dual Diagnosis
DOI: 10.1080/17523281.2010.504645
2010Prenatal tobacco exposure in first-episode psychosis
Schizophrenia Research
DOI: 10.1016/j.schres.2010.01.004
2010A Novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia
Neuropsychopharmacology
DOI: 10.1038/npp.2009.228
2010Predictors of starting to smoke cigarettes in patients with first episode psychosis
Schizophrenia Research
DOI: 10.1016/j.schres.2008.12.013
2009MAG gene variation and cortical gray matter volume in first episode schizophrenia
Brain Imaging and Behavior
DOI: 10.1007/s11682-008-9023-6
2008Cumulative concussion exposure in rugby players: Neurocognitive and symptomatic outcomes
Journal of Clinical and Experimental Neuropsychology
DOI: 10.1080/13803390701443662
2008Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment
Journal of Psychiatry and Neuroscience
2007Conceptual and methodological issues in the design of clinical trials of antipsychotics for the treatment of schizophrenia
CNS Drugs
DOI: 10.2165/00023210-200721090-00001
2007The Impact of Monetary Reward on Memory in Schizophrenia Spectrum Disorder
Neuropsychology
DOI: 10.1037/0894-4105.21.5.631
2007Functional neuroimaging of working memory in schizophrenia: Task performance as a moderating variable.
Neuropsychology
Jared X. Van Snellenberg and Ivan J. Torres and Allen E. Thornton
DOI: 10.1037/0894-4105.20.5.497
2006Clozapine alone versus clozapine and risperidone with refractory schizophrenia
New England Journal of Medicine
DOI: 10.1056/NEJMoa053222
2006The impact of atypical antipsychotic medications on long-term memory dysfunction in schizophrenia spectrum disorder: A quantitative review
Journal of Psychopharmacology
DOI: 10.1177/0269881105057002
2006A meta-analysis of profile and time-course of symptom change in acute schizophrenia treated with atypical antipsychotics
International Journal of Neuropsychopharmacology
DOI: 10.1017/S1461145705005961
2006The authors reply [4]
New England Journal of Medicine
2006The need for speed: An update on methamphetamine addiction
Journal of Psychiatry and Neuroscience
2006Memory interference in multiple sclerosis
Journal of the International Neuropsychological Society
STEPHANIE Y. GRIFFITHS and AIKO YAMAMOTO and VANESSA G. BOUDREAU and LESLIE K. ROSS and ELIZABETH KOZORA and ALLEN E. THORNTON
DOI: 10.1017/s135561770505085x
10/2005A meta-analysis of profile and time-course of symptom change in acute schizophrenia treated with atypical antipsychotics
The International Journal of Neuropsychopharmacology
Megan Sherwood and Allen E. Thornton and William G. Honer
DOI: 10.1017/s1461145705005961
09/2005Material-specific episodic memory associates of the psychomotor poverty syndrome in schizophrenia
Cognitive Neuropsychiatry
Allen E. Thornton and Christian C. Ruff and Steffen Moritz and Peter F. Liddle and Todd S. Woodward
DOI: 10.1080/13546800344000219
03/2004Methodological considerations regarding the association of Stroop and verbal fluency performance with the symptoms of schizophrenia
Schizophrenia Research
DOI: 10.1016/S0920-9964(02)00211-6
2003Donepezil for memory dysfunction in schizophrenia
Journal of Psychopharmacology
Andrew K. Howard and Allen E. Thornton and Siemion Altman and William G. Honer
DOI: 10.1177/026988110201600313
05/2002Memory in multiple sclerosis: Contextual encoding deficits
Journal of the International Neuropsychological Society
ALLEN E. THORNTON and NAFTALI RAZ and KAREN A. TUCKER
DOI: 10.1017/s1355617702813200
03/2002Memory in multiple sclerosis: Contextual encoding deficits
Journal of the International Neuropsychological Society
DOI: 10.1017/S1355617702813200
2002The Utility of Neuropsychological Evaluation in Mesial Temporal Sclerosis
The Epilepsies
Allen E. Thornton and Richard I. Naugle
DOI: 10.1016/b978-012422150-5/50028-7
1999Neuropsychological effect of temporal lobe resection in preadolescent children with epilepsy
Epilepsia
1998Memory impairment in multiple sclerosis: A quantitative review.
Neuropsychology
Allen E. Thornton and Naftali Raz
DOI: 10.1037/0894-4105.11.3.357
1997Selective aging of the human cerebral cortex observed in Vivo: Differential vulnerability of the prefrontal gray matter
Cerebral Cortex
1997Sustained attention after severe closed head injury.
Neuropsychology
Wendy J. Loken and Allen E. Thornton and Randall L. Otto and Charles J. Long
DOI: 10.1037/0894-4105.9.4.592
1995Selective neuroanatomic abnormalities in down’s syndrome and their cognitive correlates: Evidence from mri morphometry
Neurology
1995Research productivity of psychologists in VA medical centers based on APA journal publication.
Professional Psychology: Research and Practice
W. Miles Cox and Allen E. Thornton
DOI: 10.1037/0735-7028.19.3.255
1988Some fear-potentiating effects of fluprazine hydrochloride in mice
Aggressive Behavior
Ernest D. Kemble and Allen E. Thornton and Lori A. Schultz
DOI: 10.1002/1098-2337(1987)13:53.0.co;2-2
1987Increases in alcohol and other drug articles during 15 years.
Psychology of Addictive Behaviors
W. Miles Cox and Allen E. Thornton
DOI: 10.1037/h0084852
1987Effects of fluprazine hydrochloride on conspecific odor preferences in rats
Physiology & Behavior
Ernest D. Kemble and Lori A. Schultz and Allen E. Thornton
DOI: 10.1016/0031-9384(86)90383-5
01/1986Effects of fluprazine hydrochloride on an olfactory discrimination in rats
Bulletin of the Psychonomic Society
DOI: 10.3758/BF03330582
1986Inhibition and Episodic Memory Impact Age Differences in Hindsight Bias
PsycEXTRA Dataset
Alisha C. Coolin and Daniel M. Bernstein and Allen E. Thornton and Wendy J. L. Thornton
DOI: 10.1037/e659722012-001 - Research
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Research Group Members
Caitlin Courchesne, Masters Student
Samantha Feldman
Paul Jones, Clinical Trainee
Emily Livingston, Graduate Student
Tiffany O'Connor, Masters Student
Anna Petersson
Charanveer Sahota
Maddy Teasell
Kristina Waclawik
Congratulations CIHR Project Grant Recipients!
Congratulations to the BC Children's and BC Women's investigators who were awarded funding through the highly competitive Canadian Institutes of Health Research (CIHR) Project Grant Fall 2019 competition.
