- Overview
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We co-exist in harmony with huge numbers of bacteria, many within our own gastrointestinal (GI) tracts. On occasion, however, particularly virulent bacteria called pathogens (Salmonella, EHEC O157:H7) infect our intestines and cause severe, even fatal, disease. To fight infections, our immune system must recognize these bacteria as harmful and trigger a protective immune response. Some individuals appear highly susceptible to infections, perhaps because their immune systems are unable to recognize or effectively deal with the bacteria. Inappropriate recognition of pathogens may also contribute to chronic diseases of the GI tract such as Crohn's disease and other inflammatory bowel diseases (IBD). We believe that in IBD an individual’s immune system mistakes harmless bacteria for pathogens and attacks them, causing chronic inflammation. Using immunological and microbiological techniques, we’re learning how our immune systems recognize bacteria in the GI tract. We’re also identifying the factors that can provide resistance or susceptibility to intestinal infections, and exploring the mechanisms underlying the dysfunctional pathogen recognition that can trigger chronic IBD.
- Publications
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Cutting Edge: Intestinal Mucus Limits the Clonal Deletion of Developing T Cells Specific for an Oral Antigen
The Journal of Immunology
Kevin Tsai and Yu-Hsuan Huang and Caixia Ma and Troy A. Baldwin and Kenneth W. Harder and Bruce A. Vallance and John J. Priatel
DOI: 10.4049/jimmunol.1900687
07/2020Intestinal-epithelial LSD1 controls cytoskeletal-mediated cell identity including goblet cell effector responses required for gut inflammatory and infectious diseases
Parmar N and Burrows K and Lindholm HT and Zwiggelaar RT and Martín-Alonso M and Fosslie M and Vallance B and Dahl JA and Zaph C and Oudhoff MJ
DOI: 10.1101/2020.07.09.186114
07/2020Enteroids Derived From Inflammatory Bowel Disease Patients Display Dysregulated Endoplasmic Reticulum Stress Pathways, Leading to Differential Inflammatory Responses and Dendritic Cell Maturation.
Journal of Crohn's & colitis
Rees WD and Stahl M and Jacobson K and Bressler B and Sly LM and Vallance BA and Steiner TS
DOI: 10.1093/ecco-jcc/jjz194
PubMed: 31796949
07/2020Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes
PLOS Pathogens
Shauna M. Crowley and Xiao Han and Joannie M. Allaire and Martin Stahl and Isabella Rauch and Leigh A. Knodler and Bruce A. Vallance
DOI: 10.1371/journal.ppat.1008498
04/2020Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes
Infection and Immunity
Mayumi K. Holly and Xiao Han and Edward J. Zhao and Shauna M. Crowley and Joannie M. Allaire and Leigh A. Knodler and Bruce A. Vallance and Jason G. Smith
DOI: 10.1128/IAI.00017-20
04/2020A51 UTILIZING MUCIN-DERIVED SUGARS CONFERS A FITNESS ADVANTAGE TO THE ENTERIC PATHOGEN CITROBACTER RODENTIUM THAT PROMOTES INTESTINAL COLONIZATION.
Journal of the Canadian Association of Gastroenterology
Mslati M and Liang Q and Yu H and Ma C and Vallance B
02/2020A18 BUILDING BETTER ENTEROIDS: A NOVEL STRATEGY FOR ENRICHING SECRETORY EPITHELIAL CELL SUBTYPES.
Journal of the Canadian Association of Gastroenterology
Davies EE and Crowley SM and Tsai K and Diaz Gomez M and Han X and Vallance B
02/2020A52 BUTYRATE SUPPLEMENTATION AMELIORATES DAMAGE CAUSED BY ENTERIC CITROBACTER RODENTIUM INFECTION.
Journal of the Canadian Association of Gastroenterology
Celiberto LS and Healey G and Xu J and Xia L and Vallance B
02/2020A46 THE INFLAMMATORY CASPASES COORDINATE MUCOSAL RESTRICTION OF SALMONELLA THROUGH THE EPITHELIAL-INTRINSIC INFLAMMASOME AND IL-22 DRIVEN MUCIN SECRETION.
Journal of the Canadian Association of Gastroenterology
Crowley SM and Allaire JM and Han X and Graef FA and Stahl M and Knodler L and Vallance B
02/2020A202 DYSREGULATED ENDOPLASMIC RETICULUM STRESS PATHWAYS IN COLON-DERIVED ENTEROIDS FROM INFLAMMATORY BOWEL DISEASE PATIENTS DRIVE DC MATURATION LEADING TO A PRO-INFLAMMATORY PHENOTYPE.
Journal of the Canadian Association of Gastroenterology
Rees WD and Stahl M and Jacobson K and Bressler B and Sly LM and Vallance B and Steiner T
02/2020A44 NOVEL AND HIGHLY SENSITIVE FLOW CYTOMETRIC BASED METHOD FOR CONTINUOUS TRACKING OF INTESTINAL PERMEABILTIY.
Journal of the Canadian Association of Gastroenterology
Tsai K and Ma C and Crowley SM and Priatel J and Vallance B
02/2020A12 SKIN EXPOSURE TO NARROW BAND UVB LIGHT MODULATES THE HUMAN INTESTINAL MICROBIOME.
Journal of the Canadian Association of Gastroenterology
Bosman ES and Albert AY and Dutz JP and Vallance B
02/2020Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium
PLoS Pathogens
Taylor, G.A. and Huang, H. and Fee, B.E. and Youssef, N. and Jewell, M.L. and Cantillana, V. and Schoenborn, A.A. and Rogala, A.R. and Buckley, A.F. and Feng, C.G. and Vallance, B.A. and Gulati, A.S. and Hammer, G.E.
DOI: 10.1371/journal.ppat.1008553
2020Giardia spp. promote the production of antimicrobial peptides and attenuate disease severity induced by attaching and effacing enteropathogens via the induction of the NLRP3 inflammasome
International Journal for Parasitology
Manko-Prykhoda, A. and Allain, T. and Motta, J.-P. and Cotton, J.A. and Feener, T. and Oyeyemi, A. and Bindra, S. and Vallance, B.A. and Wallace, J.L. and Beck, P. and Buret, A.G.
DOI: 10.1016/j.ijpara.2019.12.011
2020Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn's Disease.
Inflammatory bowel diseases
Turpin W and Espin-Garcia O and Bedrani L and Madsen K and Meddings JB and Raygoza Garay JA and Silverberg MS and Smith MI and Griffiths AM and Moayyedi P and Marshall JK and Mack D and Croitoru K
DOI: 10.1093/ibd/izz116
PubMed: 31251335
10/2019Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium
Taylor GA and Huang H and Fee BE and Yousssef N and Cantillana V and Schoenborn AA and Rogala AR and Buckley AF and Vallance BA and Gulati AS and Hammer GE
DOI: 10.1101/575415
03/2019A9 IL37 SIGNALING THROUGH SIGIRR: A NOVEL APPROACH TO SUPPRESS INTESTINAL INFLAMMATION.
Journal of the Canadian Association of Gastroenterology
Allaire JM and Crowley SM and Han X and Poon A and Vallance B
03/2019A37 DEFECTS IN INTESTINAL MUCUS DISRUPTS THE REPERTOIRE OF DEVELOPING T CELLS IN THE THYMUS.
Journal of the Canadian Association of Gastroenterology
Tsai K and Huang Y and Ma C and Vallance B and Priatel J
03/2019A11 THE INFLAMMATORY CASPASES COORDINATE MUCOSAL RESTRICTION OF THROUGH THE EPITHELIAL-INTRINSIC INFLAMMASOME.
Journal of the Canadian Association of Gastroenterology
Crowley SM and Allaire JM and Han X and Graef FA and Stahl M and Knodler L and Rauch I and Vallance B
03/2019A156 SIALIC ACID UTILIZATION IS ESSENTIAL FOR THE IN VIVO METABOLIC FITNESS OF THE ENTERIC BACTERIAL PATHOGEN.
Journal of the Canadian Association of Gastroenterology
Liang Q and Yu H and Vallance B
03/2019A17 THE NEUROPEPTIDE VIP REGULATES INTESTINAL IMMUNITY THROUGH MODULATING THE ACTIVATION AND RECRUITMENT OF GROUP 3 INNATE LYMPHOID CELLS.
Journal of the Canadian Association of Gastroenterology
Yu H and Yang H and Ma C and Liang Q and Bosman ES and Graef FA and Reid GS and Waschek JA and Osborne L and Vallance B and Jacobson K
03/2019A153 EPITHELIAL-INTRINSIC INFLAMMASOME SIGNALING REVEALED USING SEROVAR TYPHIMURIUM INFECTION OF ENTEROID DERIVED MONOLAYERS.
Journal of the Canadian Association of Gastroenterology
Han X and Crowley SM and Allaire JM and Stahl M and Knodler L and Vallance B
03/2019A41 ENDOPLASMIC RETICULUM STRESSED HUMAN COLON ORGANOIDS CONDITION DENDRITIC CELLS TO A PRO-INFLAMMATORY PHENOTYPE.
Journal of the Canadian Association of Gastroenterology
Rees WD and Steiner T and Vallance B and Stahl M and Jacobson K
03/2019Escherichia coli pathobionts associated with inflammatory bowel disease
Clinical Microbiology Reviews
Mirsepasi-Lauridsen, H.C. and Vallance, B.A. and Krogfelt, K.A. and Petersen, A.M.
DOI: 10.1128/CMR.00060-18
2019Suppressive and Gut-Reparative Functions of Human Type 1 T Regulatory Cells
Gastroenterology
Cook, L. and Stahl, M. and Han, X. and Nazli, A. and MacDonald, K.N. and Wong, M.Q. and Tsai, K. and Dizzell, S. and Jacobson, K. and Bressler, B. and Kaushic, C. and Vallance, B.A. and Steiner, T.S. and Levings, M.K.
DOI: 10.1053/j.gastro.2019.09.002
2019Microbiota inhibit epithelial pathogen adherence by epigenetically regulating C-type lectin expression
Frontiers in Immunology
Woo, V. and Eshleman, E.M. and Rice, T. and Whitt, J. and Vallance, B.A. and Alenghat, T.
DOI: 10.3389/fimmu.2019.00928
2019Erratum: The Intestinal Epithelium: Central Coordinator of Mucosal Immunity (Trends in Immunology (2018) 39(9) (677–696), (S1471490618300681), (10.1016/j.it.2018.04.002))
Trends in Immunology
Allaire, J.M. and Crowley, S.M. and Law, H.T. and Chang, S.-Y. and Ko, H.-J. and Vallance, B.A.
DOI: 10.1016/j.it.2018.12.008
2019Macrophage ß2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis
Cell Reports
Wang, B. and Lim, J.-H. and Kajikawa, T. and Li, X. and Vallance, B.A. and Moutsopoulos, N.M. and Chavakis, T. and Hajishengallis, G.
DOI: 10.1016/j.celrep.2019.01.054
2019A novel mouse model of enteric vibrio parahaemolyticus infection reveals that the type iii secretion system 2 effector vopc plays a key role in tissue invasion and gastroenteritis
mBio
Yang, H. and Santos, M.S. and Lee, J. and Law, H.T. and Chimalapati, S. and Verdu, E.F. and Vallance, B.A. and Orth, K.
DOI: 10.1128/mBio.02608-19
2019EspF is crucial for citrobacter rodentium-induced tight junction disruption and lethality in immunocompromised animals
PLoS Pathogens
Xia, X. and Liu, Y. and Hodgson, A. and Xu, D. and Guo, W. and Yu, H. and She, W. and Zhou, C. and Lan, L. and Fu, K. and Vallance, B.A. and Wan, F.
DOI: 10.1371/journal.ppat.1007898
2019TLR9 limits enteric antimicrobial responses and promotes microbiota-based colonisation resistance during Citrobacter rodentium infection
Cellular Microbiology
Yang, H. and Yu, H.B. and Bhinder, G. and Ryz, N.R. and Lee, J. and Yang, H. and Fotovati, A. and Gibson, D.L. and Turvey, S.E. and Reid, G.S. and Vallance, B.A.
DOI: 10.1111/cmi.13026
2019IL-22 preserves gut epithelial integrity and promotes disease remission during chronic Salmonella infection
Journal of Immunology
Lo, B.C. and Shin, S.B. and Hernaez, D.C. and Refaeli, I. and Yu, H.B. and Goebeler, V. and Cait, A. and Mohn, W.W. and Vallance, B.A. and McNagny, K.M.
DOI: 10.4049/jimmunol.1801308
2019Skin exposure to narrow band ultraviolet (Uvb) light modulates the human intestinal microbiome
Frontiers in Microbiology
Bosman, E.S. and Albert, A.Y. and Lui, H. and Dutz, J.P. and Vallance, B.A.
DOI: 10.3389/fmicb.2019.02410
2019Poor Correlation of Oral Swabs with Esophageal Eosinophil Counts
Dysphagia
Avinashi, V. and Chan, J.M. and Bush, J.W. and Vallance, B.A. and Yang, H. and Portales-Casamar, E. and Soller, L. and Mill, C. and Chan, E.S.
DOI: 10.1007/s00455-019-10082-1
2019I¿B¿ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production
Scientific Reports
Ahn, J.-H. and Cho, J. and Kwon, B.-E. and Lee, G.-S. and Yoon, S.-I. and Kang, S.G. and Kim, P.-H. and Kweon, M.-N. and Yang, H. and Vallance, B.A. and Kim, Y.-I. and Chang, S.-Y. and Ko, H.-J.
DOI: 10.1038/s41598-019-44019-3
2019Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria
Journal of Experimental Medicine
Melo-Gonzalez, F. and Kammoun, H. and Evren, E. and Dutton, E.E. and Papadopoulou, M. and Bradford, B.M. and Tanes, C. and Fardus-Reid, F. and Swann, J.R. and Bittinger, K. and Mabbott, N.A. and Vallance, B.A. and Willinger, T. and Withers, D.R. and Hepworth, M.R.
DOI: 10.1084/jem.20180871
2019Long-term effects of early-life antibiotic exposure on resistance to subsequent bacterial infection
mBio
Roubaud-Baudron, C. and Ruiz, V.E. and Swan, A.M. and Vallance, B.A. and Ozkul, C. and Pei, Z. and Li, J. and Battaglia, T.W. and Perez-Perez, G.I. and Blaser, M.J.
DOI: 10.1128/mBio.02820-19
2019Bacterial AB
5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates
Nature Communications
Patry, R.T. and Stahl, M. and Perez-Munoz, M.E. and Nothaft, H. and Wenzel, C.Q. and Sacher, J.C. and Coros, C. and Walter, J. and Vallance, B.A. and Szymanski, C.M.
DOI: 10.1038/s41467-019-09362-z
2019Report on the Canadian Association of Gastroenterology Visiting Research Professorship and Visiting Clinical Professorship.
Journal of the Canadian Association of Gastroenterology
Vallance B and Waschke K
DOI: 10.1093/jcag/gwx004
PubMed: 31294397
02/2018A8 PROLONGED FASTING ALTERS THE GUT MICROBIOME AND PROTECTS AGAINST -INDUCED GUT INFLAMMATION.
Journal of the Canadian Association of Gastroenterology
Graef FA and Lau J and Bosman ES and Kuan M and Yang H and Celiberto LS and Berkmann JC and Stahl M and Crowley SM and Yu H and Surette M and Verdu E and Jacobson K and Vallance B
02/2018A295 FUCOSE AVAILABILITY AND ITS UTILIZATION IMPACT ENTERIC PATHOGEN VIRULENCE.
Journal of the Canadian Association of Gastroenterology
Allaire JM and Bhullar K and Crowley SM and Stahl M and Yang H and Verdu E and YU H and Vallance B
02/2018A14 INFLAMMASOME ACTIVATION COORDINATES INTESTINAL MUCOSAL DEFENSE AGAINST THE ENTERIC BACTERIAL PATHOGEN SEROVAR TYPHIMURIUM.
Journal of the Canadian Association of Gastroenterology
Crowley SM and Graef FA and Allaire JM and Knodler LA and Vallance B
02/2018A292 NLRP -DEPENDENT PRODUCTION OF ANTIMICROBIAL PEPTIDES DURING CO-INFECTION WITH AND.
Journal of the Canadian Association of Gastroenterology
Manko A and Motta J and Cotton J and Oyeyemi A and Vallance B and Wallace JL and Buret A
02/2018A10 AN ULCERATIVE COLITIS ESCHERICHIA COLI PATHOBIONT COLONIZES THE INTESTINAL MUCOSA OF SUSCEPTIBLE HOSTS AND PROMOTES COLITIS VIA HEMOLYSIN PRODUCTION.
Journal of the Canadian Association of Gastroenterology
Yang H and Mirsepasi-Lauridsen HC and Bosman ES and Struve C and Yu H and Wu X and Ma C and Reid G and Li X and Petersen AM and Jacobson K and Krogfelt KA and Vallance B
02/2018A98 VASOACTIVE INTESTINAL PEPTIDE PROMOTES TH17 IMMUNE RESPONSES THEREBY PROTECTING AGAINST CITROBACTER RODENTIUM INDUCED COLITIS.
Journal of the Canadian Association of Gastroenterology
YU H and Wu X and Yang H and Celiberto LS and Graef FA and Bosman ES and Ma C and Huang T and Reid G and Vallance B and Jacobson K
02/2018A277 THE FIRST LINE OF DEFENSE: THE ROLE OF EPITHELIAL CELL INFLAMMASOMES IN CONTROLLING INFECTION.
Journal of the Canadian Association of Gastroenterology
Stahl M and Hoang T and Knodler LA and Vallance B
02/2018A107 TOLL LIKE RECEPTOR 9 LIMITS INTESTINAL INFLAMMATION AND PROMOTES MICROBIOTA BASED COLONIZATION RESISTANCE DURING CITROBACTER RODENTIUM INFECTION.
Journal of the Canadian Association of Gastroenterology
Yang H and Yu H and Bhinder G and Ryz NR and Yang H and Fotovati A and Gibson DL and Turvey SE and Reid G and Vallance B
02/2018A10 CORE-1 DERIVED -GLYCOSYLATION OF THE MUCIN MUC2 PLAYS A KEY ROLE IN HOST DEFENSE AGAINST ENTERIC INFECTION.
Journal of the Canadian Association of Gastroenterology
Celiberto LS and Chan JY and Law HT and Bhullar K and Xia L and Cavallini DC and Vallance B
02/2018A274 GUT MICROBIOTA REGULATES INNATE EPITHELIAL RESPONSES AGAINST AN ENTERIC BACTERIAL PATHOGEN.
Journal of the Canadian Association of Gastroenterology
Allaire JM and Yang H and Moore N and Crowley SM and Verdu E and Vallance B
02/2018The Muc2 mucin coats murine paneth cell granules and facilitates their content release and dispersion
American Journal of Physiology - Gastrointestinal and Liver Physiology
Stahl, M. and Tremblay, S. and Montero, M. and Vogl, W. and Xia, L. and Jacobson, K. and Menendez, A. and Vallance, B.A.
DOI: 10.1152/ajpgi.00264.2017
2018First-reported pediatric cases of American ginseng anaphylaxis and allergy
Allergy, Asthma and Clinical Immunology
Erdle, S.C. and Chan, E.S. and Yang, H. and Vallance, B.A. and Mill, C. and Wong, T.
DOI: 10.1186/s13223-018-0304-3
2018Genetic ablation of cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition
American Journal of Physiology - Endocrinology and Metabolism
Patankar, J.V. and Wong, C.K. and Morampudi, V. and Gibson, W.T. and Vallance, B. and Ioannou, G.N. and Hayden, M.R.
DOI: 10.1152/ajpendo.00172.2017
2018Isolation and characterization of potentially probiotic bacterial strains from mice: proof of concept for personalized probiotics
Nutrients
Celiberto, L.S. and Pinto, R.A. and Rossi, E.A. and Vallance, B.A. and Cavallini, D.C.U.
DOI: 10.3390/nu10111684
2018Immune Stimulation Using a Gut Microbe-Based Immunotherapy Reduces Disease Pathology and Improves Barrier Function in Ulcerative Colitis
Frontiers in immunology
Sham, H.P. and Bazett, M. and Bosiljcic, M. and Yang, H. and Luk, B. and Law, H.T. and Morampudi, V. and Yu, H.B. and Pankovich, J. and Sutcliffe, S. and Bressler, B. and Marshall, J.K. and Fedorak, R.N. and Chen, J. and Jones, M. and Gunn, H. and Kalyan, S. and Vallance, B.A.
DOI: 10.3389/fimmu.2018.02211
2018The Intestinal Epithelium: Central Coordinator of Mucosal Immunity
Trends in Immunology
Allaire, J.M. and Crowley, S.M. and Law, H.T. and Chang, S.-Y. and Ko, H.-J. and Vallance, B.A.
DOI: 10.1016/j.it.2018.04.002
2018Pediatric eosinophilic esophagitis is associated with increased lamina propria immunoglobulin g4-positive plasma cells
Journal of Pediatric Gastroenterology and Nutrition
Mohammad, N. and Avinashi, V. and Chan, E. and Vallance, B.A. and Portales-Casamar, E. and Bush, J.W.
DOI: 10.1097/MPG.0000000000001949
2018Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome
Immunology
Celiberto, L.S. and Graef, F.A. and Healey, G.R. and Bosman, E.S. and Jacobson, K. and Sly, L.M. and Vallance, B.A.
DOI: 10.1111/imm.12939
2018Frontline defenders: Goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and disease
American Journal of Physiology - Gastrointestinal and Liver Physiology
Allaire, J.M. and Morampudi, V. and Crowley, S.M. and Stahl, M. and Yu, H. and Bhullar, K. and Knodler, L.A. and Bressler, B. and Jacobson, K. and Vallance, B.A.
DOI: 10.1152/ajpgi.00181.2017
2018Epithelial Histone Deacetylase 3 Instructs Intestinal Immunity by Coordinating Local Lymphocyte Activation
Cell Reports
Navabi, N. and Whitt, J. and Wu, S.-E. and Woo, V. and Moncivaiz, J. and Jordan, M.B. and Vallance, B.A. and Way, S.S. and Alenghat, T.
DOI: 10.1016/j.celrep.2017.04.046
2017Noncanonical inflammasomes: Antimicrobial defense that does not play by the rules
Cellular Microbiology
Crowley, S.M. and Vallance, B.A. and Knodler, L.A.
DOI: 10.1111/cmi.12730
2017Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease
PLoS ONE
Manko, A. and Motta, J.-P. and Cotton, J.A. and Feener, T. and Oyeyemi, A. and Vallance, B.A. and Wallace, J.L. and Buret, A.G.
DOI: 10.1371/journal.pone.0178647
2017Tricellular tight junction protein tricellulin is targeted by the enteropathogenic Escherichia coli effector EspG1, leading to epithelial barrier disruption
Infection and Immunity
Morampudi, V. and Graef, F.A. and Stahl, M. and Dalwadi, U. and Conlin, V.S. and Huang, T. and Vallance, B.A. and Yu, H.B. and Jacobson, K.
DOI: 10.1128/IAI.00700-16
2017Mouse models for Campylobacter jejuni colonization and infection
Methods in Molecular Biology
Stahl, M. and Graef, F.A. and Vallance, B.A.
DOI: 10.1007/978-1-4939-6536-6_15
2017A simple, cost-effective method for generating murine colonic 3D enteroids and 2D monolayers for studies of primary epithelial cell function
American Journal of Physiology - Gastrointestinal and Liver Physiology
Fernando, E.H. and Dicay, M. and Stahl, M. and Gordon, M.H. and Vegso, A. and Baggio, C. and Alston, L. and Lopes, F. and Baker, K. and Hirota, S. and McKay, D.M. and Vallance, B. and MacNaughton, W.K.
DOI: 10.1152/ajpgi.00152.2017
2017Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development
Scientific Reports
Bhinder, G. and Allaire, J.M. and Garcia, C. and Lau, J.T. and Chan, J.M. and Ryz, N.R. and Bosman, E.S. and Graef, F.A. and Crowley, S.M. and Celiberto, L.S. and Berkmann, J.C. and Dyer, R.A. and Jacobson, K. and Surette, M.G. and Innis, S.M. and Vallance, B.A.
DOI: 10.1038/srep45274
2017Association of host genome with intestinal microbial composition in a large healthy cohort.
Nature genetics
Turpin W and Espin-Garcia O and Xu W and Silverberg MS and Kevans D and Smith MI and Guttman DS and Griffiths A and Panaccione R and Otley A and Xu L and Shestopaloff K and Croitoru K
DOI: 10.1038/ng.3693
PubMed: 27694960
10/2016The helical shape of Campylobacter jejuni promotes in vivo pathogenesis by aiding transit through intestinal mucus and colonization of crypts
Infection and Immunity
Stahl, M. and Frirdich, E. and Vermeulen, J. and Badayeva, Y. and Li, X. and Vallance, B.A. and Gaynor, E.C.
DOI: 10.1128/IAI.00751-16
2016mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium
Scientific Reports
Lin, X. and Yang, J. and Wang, J. and Huang, H. and Wang, H.-X. and Chen, P. and Wang, S. and Pan, Y. and Qiu, Y.-R. and Taylor, G.A. and Vallance, B.A. and Gao, J. and Zhong, X.-P.
DOI: 10.1038/srep34939
2016NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis
Cell Death and Differentiation
Chung, H. and Vilaysane, A. and Lau, A. and Stahl, M. and Morampudi, V. and Bondzi-Simpson, A. and Platnich, J.M. and Bracey, N.A. and French, M.-C. and Beck, P.L. and Chun, J. and Vallance, B.A. and Muruve, D.A.
DOI: 10.1038/cdd.2016.14
2016Investigation of host and pathogen contributions to infectious colitis using the citrobacter rodentium mouse model of infection
Methods in Molecular Biology
Bosman, E.S. and Chan, J.M. and Bhullar, K. and Vallance, B.A.
DOI: 10.1007/978-1-4939-3603-8_21
2016Salmonella and the inflammasome: Battle for intracellular dominance
Current Topics in Microbiology and Immunology
Crowley, S.M. and Knodler, L.A. and Vallance, B.A.
DOI: 10.1007/978-3-319-41171-2_3
2016Dynamic interactions of a conserved enterotoxigenic Escherichia coli adhesin with intestinal mucins govern epithelium engagement and toxin delivery
Infection and Immunity
Kumar, P. and Kuhlmann, F.M. and Bhullar, K. and Yang, H. and Vallance, B.A. and Xia, L. and Luo, Q. and Fleckenstein, J.M.
DOI: 10.1128/IAI.00692-16
2016The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria
PLoS Pathogens
Singh, K. and Al-Greene, N.T. and Verriere, T.G. and Coburn, L.A. and Asim, M. and Barry, D.P. and Allaman, M.M. and Hardbower, D.M. and Delgado, A.G. and Piazuelo, M.B. and Vallance, B.A. and Gobert, A.P. and Wilson, K.T.
DOI: 10.1371/journal.ppat.1005984
2016Prolonged antibiotic treatment induces a diabetogenic intestinal microbiome that accelerates diabetes in NOD mice
ISME Journal
Brown, K. and Godovannyi, A. and Ma, C. and Zhang, Y. and Ahmadi-Vand, Z. and Dai, C. and Gorzelak, M.A. and Chan, Y. and Chan, J.M. and Lochner, A. and Dutz, J.P. and Vallance, B.A. and Gibson, D.L.
DOI: 10.1038/ismej.2015.114
2016The goblet cell-derived mediator RELM-ß drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis
Mucosal Immunology
Morampudi, V. and Dalwadi, U. and Bhinder, G. and Sham, H.P. and Gill, S.K. and Chan, J. and Bergstrom, K.S.B. and Huang, T. and Ma, C. and Jacobson, K. and Gibson, D.L. and Vallance, B.A.
DOI: 10.1038/mi.2015.140
2016Expression of the Blood-Group-Related Gene B4galnt2 Alters Susceptibility to Salmonella Infection
PLoS Pathogens
Rausch, P. and Steck, N. and Suwandi, A. and Seidel, J.A. and K{\"u}nzel, S. and Bhullar, K. and Basic, M. and Bleich, A. and Johnsen, J.M. and Vallance, B.A. and Baines, J.F. and Grassl, G.A.
DOI: 10.1371/journal.ppat.1005008
2015Metalloprotease NleC Suppresses Host NF-¿B/Inflammatory Responses by Cleaving p65 and Interfering with the p65/RPS3 Interaction
PLoS Pathogens
Hodgson, A. and Wier, E.M. and Fu, K. and Sun, X. and Yu, H. and Zheng, W. and Sham, H.P. and Johnson, K. and Bailey, S. and Vallance, B.A. and Wan, F.
DOI: 10.1371/journal.ppat.1004705
2015Humoral immunity in the gut selectively targets phenotypically virulent attaching-and-effacing bacteria for intraluminal elimination
Cell Host and Microbe
Kamada, N. and Sakamoto, K. and Seo, S.-U. and Zeng, M.Y. and Kim, Y.-G. and Cascalho, M. and Vallance, B.A. and Puente, J.L. and N{\'u}{\~n}ez, G.
DOI: 10.1016/j.chom.2015.04.001
2015The serine protease autotransporter Pic modulates Citrobacter rodentium pathogenesis and its innate recognition by the host
Infection and Immunity
Bhullar, K. and Zarepour, M. and Yu, H. and Yang, H. and Croxen, M. and Stahl, M. and Finlay, B.B. and Turvey, S.E. and Vallance, B.A.
DOI: 10.1128/IAI.00025-15
2015Dietary vitamin D3 deficiency alters intestinal mucosal defense and increases susceptibility to Citrobacter rodentium-induced colitis
American Journal of Physiology - Gastrointestinal and Liver Physiology
Ryz, N.R. and Lochner, A. and Bhullar, K. and Ma, C. and Huang, T. and Bhinder, G. and Bosman, E. and Wu, X. and Innis, S.M. and Jacobson, K. and Vallance, B.A.
DOI: 10.1152/ajpgi.00006.2015
2015Active Transport of Phosphorylated Carbohydrates Promotes Intestinal Colonization and Transmission of a Bacterial Pathogen
PLoS Pathogens
Sit, B. and Crowley, S.M. and Bhullar, K. and Lai, C.C.-L. and Tang, C. and Hooda, Y. and Calmettes, C. and Khambati, H. and Ma, C. and Brumell, J.H. and Schryvers, A.B. and Vallance, B.A. and Moraes, T.F.
DOI: 10.1371/journal.ppat.1005107
2015Goblet Cell Derived RELM-ß Recruits CD4+ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation
PLoS Pathogens
Bergstrom, K.S.B. and Morampudi, V. and Chan, J.M. and Bhinder, G. and Lau, J. and Yang, H. and Ma, C. and Huang, T. and Ryz, N. and Sham, H.P. and Zarepour, M. and Zaph, C. and Artis, D. and Nair, M. and Vallance, B.A.
DOI: 10.1371/journal.ppat.1005108
2015Vasoactive intestinal polypeptide promotes intestinal barrier homeostasis and protection against colitis in mice
PLoS ONE
Wu, X. and Conlin, V.S. and Morampudi, V. and Ryz, N.R. and Nasser, Y. and Bhinder, G. and Bergstrom, K.S. and Yu, H.B. and Waterhouse, C.C.M. and Buchan, A.M.J. and Popescu, O.E. and Gibson, W.T. and Waschek, J.A. and Vallance, B.A. and Jacobson, K.
DOI: 10.1371/journal.pone.0125225
2015Interleukin-1 (IL-1) signaling in intestinal stromal cells controls KC/ CXCL1 secretion, which correlates with recruitment of IL-22- secreting neutrophils at early stages of Citrobacter rodentium infection
Infection and Immunity
Lee, Y.-S. and Yang, H. and Yang, J.-Y. and Kim, Y. and Lee, S.-H. and Kim, J.H. and Jang, Y.J. and Vallance, B.A. and Kweon, M.-N.
DOI: 10.1128/IAI.00670-15
2015Vasoactive intestinal peptide prevents PKCe-induced intestinal epithelial barrier disruption during EPEC infection
American Journal of Physiology - Gastrointestinal and Liver Physiology
Morampudi, V. and Conlin, V.S. and Dalwadi, U. and Wu, X. and Marshall, K.C. and Nguyen, C. and Vallance, B.A. and Jacobson, K.
DOI: 10.1152/ajpgi.00195.2014
2015Insights into Campylobacter jejuni colonization of the mammalian intestinal tract using a novel mouse model of infection
Gut Microbes
Stahl, M. and Vallance, B.A.
DOI: 10.1080/19490976.2015.1016691
2015Indispensable functions of ABL and PDGF receptor kinases in epithelial adherence of attaching/effacing pathogens under physiological conditions
DOI: 10.1152/ajpcell.00013.2014
2014SLAM-SAP signaling promotes differentiation of IL-17-producing T cells and progression of experimental autoimmune encephalomyelitis
Journal of Immunology
Huang, Y.-H. and Tsai, K. and Ma, C. and Vallance, B.A. and Priatel, J.J. and Tan, R.
DOI: 10.4049/jimmunol.1301435
2014Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens
Cell Host and Microbe
Knodler, L.A. and Crowley, S.M. and Sham, H.P. and Yang, H. and Wrande, M. and Ma, C. and Ernst, R.K. and Steele-Mortimer, O. and Celli, J. and Vallance, B.A.
DOI: 10.1016/j.chom.2014.07.002
2014Intestinal epithelium-specific MyD88 signaling impacts host susceptibility to infectious colitis by promoting protective goblet cell and antimicrobial responses
DOI: 10.1128/IAI.02045-14
2014A Novel Mouse Model of Campylobacter jejuni Gastroenteritis Reveals Key Pro-inflammatory and Tissue Protective Roles for Toll-like Receptor Signaling during Infection
DOI: 10.1371/journal.ppat.1004264
2014TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen
DOI: 10.1172/JCI74428
2014DNBS/TNBS colitis models: Providing insights into inflammatory bowel disease and effects of dietary fat
Journal of Visualized Experiments
Morampudi, V. and Bhinder, G. and Wu, X. and Dai, C. and Sham, H.P. and Vallance, B.A. and Jacobson, K.
DOI: 10.3791/51297
2014CD4+ T cells drive goblet cell depletion during citrobacter rodentium infection
Infection and Immunity
Chan, J.M. and Bhinder, G. and Sham, H.P. and Ryz, N. and Huang, T. and Bergstrom, K.S. and Vallance, B.A.
DOI: 10.1128/IAI.00655-13
2013The mucin muc2 limits pathogen burdens and epithelial barrier dysfunction during salmonella enterica serovar typhimurium colitis
DOI: 10.1128/IAI.00854-13
2013Requirement of epithelial integrin-linked kinase for facilitation of Citrobacter rodentium-induced colitis
DOI: 10.1186/1471-230X-13-137
2013Activation of p38a in T cells regulates the intestinal host defense against attaching and effacing bacterial infections
DOI: 10.4049/jimmunol.1300908
2013The Citrobacter rodentium mouse model: studying pathogen and host contributions to infectious colitis.
Journal of visualized experiments : JoVE
Bhinder, G. and Sham, H.P. and Chan, J.M. and Morampudi, V. and Jacobson, K. and Vallance, B.A.
2013SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens
DOI: 10.1371/journal.ppat.1003539
2013Resistin-like molecule a promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation
DOI: 10.4049/jimmunol.1200706
2013Bacterial stimulation of the TLR-MyD88 pathway modulates the homeostatic expression of ileal paneth cell a-defensins
DOI: 10.1159/000341630
2013Active vitamin D (1,25-dihydroxyvitamin D
3 ) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses
American Journal of Physiology - Gastrointestinal and Liver Physiology
Ryz, N.R. and Patterson, S.J. and Zhang, Y. and Ma, C. and Huang, T. and Bhinder, G. and Wu, X. and Chan, J. and Glesby, A. and Sham, H.P. and Dutz, J.P. and Levings, M.K. and Jacobson, K. and Vallance, B.A.
DOI: 10.1152/ajpgi.00320.2012
2012MyD88 signaling promotes both mucosal homeostatic and fibrotic responses during Salmonella-induced colitis
DOI: 10.1152/ajpgi.00038.2012
2012Regulated virulence controls the ability of a pathogen to compete with the gut microbiota
DOI: 10.1126/science.1222195
2012Innate host responses to enteric bacterial pathogens: A balancing act between resistance and tolerance
DOI: 10.1111/j.1462-5822.2012.01750.x
2012Attaching and effacing bacterial effector NleC suppresses epithelial inflammatory responses by inhibiting NF-¿B and p38 mitogen-activated protein kinase activation
DOI: 10.1128/IAI.05033-11
2011Colonic microbiota alters host susceptibility to infectious colitis by modulating inflammation, redox status, and ion transporter gene expression
DOI: 10.1152/ajpgi.00509.2010
2011Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis
DOI: 10.1128/IAI.01104-10
2011Citrobacter rodentium infection induces MyD88-dependent formation of ubiquitinated protein aggregates in the intestinal epithelium
DOI: 10.1159/000320644
2011Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia
DOI: 10.1073/pnas.1006098107
2010Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling
DOI: 10.1053/j.gastro.2010.06.057
2010The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling
DOI: 10.1111/j.1462-5822.2010.01470.x
2010Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apcmin mice
Gastroenterology
Xiao, H. and Yin, W. and Khan, M.A. and Gulen, M.F. and Zhou, H. and Sham, H.P. and Jacobson, K. and Vallance, B.A. and Li, X.
DOI: 10.1053/j.gastro.2010.04.043
2010Epithelial p38a controls immune cell recruitment in the colonic mucosa
DOI: 10.1371/journal.ppat.1000934
2010Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa
DOI: 10.1371/journal.ppat.1000902
2010Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice
DOI: 10.1007/s00125-009-1626-y
2010Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases
DOI: 10.1016/j.immuni.2010.02.012
2010The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells
DOI: 10.4049/jimmunol.0900021
2010Innate immunity and microbes: Conversations with the gut leading to intestinal tissue repair and fibrosis
DOI: 10.2174/187152309789152002
2009Salmonella infection of gallbladder epithelial cells drives local inflammation and injury in a model of acute typhoid fever
DOI: 10.1086/646608
2009Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis
DOI: 10.1152/ajpgi.90551.2008
2009Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis
DOI: 10.1016/j.bbalip.2009.08.001
2009Nramp1 drives an accelerated inflammatory response during Salmonella -induced colitis in mice
DOI: 10.1111/j.1462-5822.2008.01258.x
2009Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection
DOI: 10.1111/j.1462-5822.2008.01155.x
2008Intestinal microbiota are transiently altered during Salmonella-induced gastroenteritis
DOI: 10.1586/17474124.2.4.525
2008A novel secretion pathway of Salmonella enterica acts as an antivirulence modulator during salmonellosis
DOI: 10.1371/journal.ppat.1000036
2008Flagellin-dependent and -independent inflammatory responses following infection by enteropathogenic Escherichia coli and Citrobacter rodentium
DOI: 10.1128/IAI.01141-07
2008Chronic Enteric Salmonella Infection in Mice Leads to Severe and Persistent Intestinal Fibrosis
DOI: 10.1053/j.gastro.2007.12.043
2008Aggregation via the red, dry, and rough morphotype is not a virulence adaptation in Salmonella enterica serovar typhimurium
DOI: 10.1128/IAI.01383-07
2008Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus
DOI: 10.1152/ajpgi.00453.2007
2008MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacterrodentium-induced colitis
DOI: 10.1111/j.1462-5822.2007.01071.x
2008Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen
DOI: 10.1128/IAI.00093-07
2008Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis
DOI: 10.1111/j.1462-5822.2007.01052.x
2008Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors
DOI: 10.1152/ajpgi.00173.2007
2007The Toll-Interleukin-1 Receptor Member SIGIRR Regulates Colonic Epithelial Homeostasis, Inflammation, and Tumorigenesis
DOI: 10.1016/j.immuni.2007.02.012
2007The adaptor Act1 is required for interleukin 17 - Dependent signaling associated with autoimmune and inflammatory disease
DOI: 10.1038/ni1439
2007Genetic profiling of dendritic cells exposed to live- or ultraviolet-irradiated Chlamydia muridarum reveals marked differences in CXC chemokine profiles
DOI: 10.1111/j.1365-2567.2006.02488.x
2007IL-4 gene transfer to the small bowel serosa leads to intestinal inflammation and smooth muscle hyperresponsiveness
DOI: 10.1152/ajpgi.00065.2006
2007Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: Role of mitochondrial associated protein (Map)
DOI: 10.1111/j.1462-5822.2006.00741.x
2006Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice
DOI: 10.1128/IAI.74.5.2522-2536.2006
2006Noradrenergic and cholinergic neural pathways mediate stress-induced reactivation of colitis in the rat
DOI: 10.1016/j.autneu.2005.12.002
2006Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine
DOI: 10.1371/journal.ppat.0010032
2005Cloning vectors and fluorescent proteins can significantly inhibit Salmonella enterica virulence in both epithelial cells and macrophages: Implications for bacterial pathogenesis studies
DOI: 10.1128/IAI.73.10.7027-7031.2005
2005TGF-ß1 gene transfer to the mouse colon leads to intestinal fibrosis
DOI: 10.1152/ajpgi.00051.2005
2005Salmonella enterica serovar Typhimurium pathogenicity island 2 is necessary for complete virulence in a mouse model of infectious enterocolitis
DOI: 10.1128/IAI.73.6.3219-3227.2005
2005Modulation of host cytoskeleton function by the enteropathogenic Escherichia coli and Citrobacter rodentium effector protein EspG
DOI: 10.1128/IAI.73.5.2586-2594.2005
2005Myenteric plexus injury and apoptosis in experimental colitis
DOI: 10.1016/j.autneu.2004.10.006
2005Relative contributions of NOS isoforms during experimental colitis: Endothelial-derived NOS maintains mucosal integrity
DOI: 10.1152/ajpgi.00187.2004
2004Modeling enteropathogenic and enterohemorrhagic E. coli infections and disease
DOI: 10.1016/j.ddmod.2004.04.001
2004SseK1 and SseK2 are novel translocated proteins of Salmonella enterica serovar Typhimurium
DOI: 10.1128/IAI.72.9.5115-5125.2004
2004Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies
DOI: 10.1128/IAI.72.6.3315-3324.2004
2004Toll-Like Receptor 4 Dependence of Innate and Adaptive Immunity to Salmonella: Importance of the Kupffer Cell Network
2004Dissecting virulence: Systematic and functional analyses of a pathogenicity island
DOI: 10.1073/pnas.0400326101
2004Salmonella type III effectors PipB and PipB2 are targeted to detergent-resistant microdomains on internal host cell membranes
DOI: 10.1046/j.1365-2958.2003.03598.x
2003Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium
DOI: 10.1128/IAI.71.6.3443-3453.2003
2003SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells
DOI: 10.1016/S1286-4579(03)00094-7
2003Erratum: SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells (Traffic (2003) vol. 4 (1) (36-48))
2003Citrobacter rodentium translocated intimin receptor (Tir) is an essential virulence factor needed for actin condensation, intestinal colonization and colonic hyperplasia in mice
DOI: 10.1046/j.1365-2958.2003.03429.x
2003SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells
DOI: 10.1034/j.1600-0854.2003.40106.x
2003Current progress in enteropathogenic and enterohemorrhagic Escherichia coli vaccines
DOI: 10.1586/14760584.1.4.483
2002Host-pathogen interactions: Host resistance factor Nramp1 up-regulates the expression of Salmonella pathogenicity island-2 virulence genes
DOI: 10.1073/pnas.252415599
2002Enteropathogenic and enterohemorrhagic Escherichia coli infections: Emerging themes in pathogenesis and prevention
2002Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen Citrobacter rodentium in infected mice
DOI: 10.1128/IAI.70.11.6424-6435.2002
2002Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems
DOI: 10.1046/j.1365-2958.2002.02820.x
2002Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection
DOI: 10.1128/IAI.70.4.2070-2081.2002
2002Neural change in Trichinella-infected mice is MHC II independent and involves M-CSF-derived macrophages
2001IL-12 gene transfer alters gut physiology and host immunity in nematode-infected mice
2001Enteropathogenic Escherichia coli infection induces expression of the early growth response factor by activating mitogen-activated protein kinase cascades in epithelial cells
DOI: 10.1128/IAI.69.10.6217-6224.2001
2001Locus of enterocyte effacement from Citrobacter rodentium: Sequence analysis and evidence for horizontal transfer among attaching and effacing pathogens
DOI: 10.1128/IAI.69.10.6323-6335.2001
2001Role of immunologic factors and cyclooxygenase 2 in persistent postinfective enteric muscle dysfunction in mice
2001Mast cell-independent impairment of host defense and muscle contraction in T. spiralis-infected W/Wv mice
American Journal of Physiology - Gastrointestinal and Liver Physiology
Vallance, B.A. and Blennerhassett, P.A. and Huizinga, J.D. and Collins, S.M.
DOI: 10.1152/ajpgi.2001.280.4.g640
2001Critical role for signal transducer and activator of transcription factor 6 in mediating intestinal muscle hypercontractility and worm expulsion in Trichinella spiralis-infected mice
DOI: 10.1128/IAI.69.2.838-844.2001
2001Interleukin-5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections
DOI: 10.1046/j.1365-3024.2000.00328.x
2000Exploitation of host cells by enteropathogenic Escherichia coli
DOI: 10.1073/pnas.97.16.8799
2000Inflammation-induced impairment of enteric nerve function in nematode- infected mice is macrophage dependent
2000CD4 T cells and major histocompatibility complex class II expression influence worm expulsion and increased intestinal muscle contraction during Trichinella spiralis infection
1999Putative inflammatory and immunological mechanisms in functional bowel disorders
DOI: 10.1053/bega.1999.0037
1999The role of CD4+ lymphocytes in the susceptibility of mice to stress- induced reactivation of experimental colitis
Nature Medicine
Qiu, B.S. and Vallance, B.A. and Blennerhassett, P.A. and Collins, S.M.
DOI: 10.1038/13503
1999IL-5 contributes to worm expulsion and muscle hypercontractility in a primary T. spiralis infection
1999Stress, inflammation and the irritable bowel syndrome.
1999Characterization of enteric functional changes evoked by in vivo anti- CD3 T cell activation
1999T lymphocyte-dependent and -independent intestinal smooth muscle dysfunction in the T. spiralis-infected mouse
1998T cell-mediated exocrine pancreatic damage in major histocompatibility complex class II-deficient mice
DOI: 10.1016/S0016-5085(98)70270-7
1998The effect of nematode infection upon intestinal smooth muscle function
DOI: 10.1046/j.1365-3024.1998.00155.x
1998Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease
1997Persistent intestinal neuromuscular dysfunction after acute nematode infection in mice
DOI: 10.1053/gast.1997.v113.pm9322517
1997Increased intestinal muscle contractility and worm expulsion in nematode-infected mice
1997Role of smooth muscle in intestinal inflammation
1996 - Research
-
Role of dendritic cells in mucosal infection and inflammation
Dendritic cells are the sentinel immune cells of the body, trafficking to mucosal sites where they acquire antigen to ultimately present to naïve T cells. Recent work in several laboratories suggests that some bacterial pathogens may infect dendritic cells at intestinal mucosal surfaces, using these cells to shuttle across the intestinal epithelial barrier to cause a systemic infection. We are currently examining the role of dendritic cells in enabling the colonization and infection of the GI tract by invasive bacteria (Salmonella) and non-invasive bacteria (EHEC), as well as their role in causing intestinal inflammation in models of IBD. Our work has also revealed that dendritic cells may actually play an active role in host defense, expressing various anti-microbial effectors. We are currently studying the mechanisms of dendritic cell mediated anti-microbial activity both in vitro and in vivo. A better understanding of the role of dendritic cells in GI inflammation may provide useful targets for improved vaccination against bacterial infections as well as provide therapeutic targets for IBD.Mechanisms underlying host susceptibility to enteric pathogens
Additional studies have identified several related mouse strains that are highly susceptible to Citrobacter rodentium, a mouse adapted version of EHEC. Susceptible animals show evidence of inflammation similar to that seen in human inflammatory bowel diseases. Using in vivo imaging, we have identified specific sites in the intestine where susceptibility first manifests, as well as the bacterial virulence factors needed to colonize these sites. We are currently identifying the genes underlying the susceptibility defect in these mice, since a similar defect may predispose humans to increasedRole of intestinal epithelial cells in controlling bacterial infections
Many intestinal bacterial pathogens – including enterohemorrhagic E. coli (EHEC O157:H7), the causative agent of the water poisoning in Walkerton, Ontario – infect the epithelial cells that line our intestines. Our recent work has shown that during such infections, epithelial cells are activated to produce a variety of anti-microbial molecules. Moreover, in vitro studies indicate that EHEC and related pathogens may inject bacterial proteins into infected epithelial cells in order to reduce the production of anti-microbial enzymes by epithelial cells. We are currently identifying the bacterial effector proteins as well as the mechanisms involved in this process.GrantsCIHR Operating Grant – Project
"Defining SIGIRR's role in epithelial homeostasis and host defense during infectious colitis" (2013-2018)
NSERC Discovery Grant and Discovery Accelerator Supplement - Project
"Vitamin D - A Regulator of Host-Microbe Interactions in the Mammalian GI Tract?" (2013-2018)
Crohn’s and Colitis Foundation of Canada Discovery Research Grants - Project
"IBD
The result of an imbalance between inflammatory versus tissue protective innate signaling?" (2013-2016)
Honours & AwardsCanada Research Chair in Pediatric Gastroenterology (Tier II) – 2004-2009
CH.I.L.D. Foundation Chair in Pediatric Gastroenterology – 2013-ongoing
Canadian Children Inflammatory Bowel Disease Network, CIHR and CH.I.L.D Foundation – 2013
Research Group MembersJoannie Allaire, Postdoctoral fellow
Else Bosman, Doctoral Student , Doctoral Student
Larissa Celiberto, Doctoral Student
Cathy Chan, Research Assistant
Jasmine Chen
Yan Chen, Student
Shauna Crowley, Doctoral Student , Doctoral Student
Emily Davies, Undergraduate Research Assistant
Travis De Wolfe, Postdoctoral fellow
Mariana Diaz Gomez, Research Assistant
Franziska Graef, PhD Student
Emily Gubski, Summer Student
Mackenzie Gutierrez, Research Assistant
Vivian Han, Graduate Student, Graduate Student
Genelle Healey, Postdoctoral Fellow
Jingtian Huang, Research Assistant
Hyun-Jeong Ko, Visiting Associate Professor
Hong Ting Law, Postdoctoral Fellow
Julia Lee, Undergraduate Research Assistant
Soomin Lee, Research Assistant
Qiaochu Liang, Graduate Student
Caixia Ma, Research Assistant / Research Technician
Clare Murphy, Research Assistant
Alana Schick, Bioinformatician
Andy Sham, Project Manager
Kevin Tsai, Post Doctoral Fellow
Hyungjun Yang
Hongbing Yu, Research Associate
Qin Yu, Visiting Scientist
Uncovering the power of a single layer of cells: Vallance Lab researchers study the intestinal epithelium to improve care for kids with inflammatory bowel diseases
A layer of tissue that’s only a single cell thick is all that that separates our intestines from the world of microbes living inside our gut. Until recently, scientists believed this layer, which is called the intestinal epithelium, was just a simple protective barrier. Thanks to work done in Dr. Bruce Vallance’s Lab at BC Children’s Hospital and elsewhere, we’re now learning that the epithelium plays a key role in human health and understanding how it works and why it fails may lead to new treatments for children with inflammatory bowel disease.
