Bruce Carleton

Investigator, BC Children's Hospital
Director, Pharmaceutical Outcomes Programme, BC Children's Hospital
Division Head, Translational Therapeutics, Department of Pediatrics, University of British Columbia

The central theme of my research program, Pharmaceutical Outcomes and Policy Innovations (POPi), is the study of drug therapy with the goal of improving human health and quality of life.

I am particularly interested in developing models for evaluating drug effectiveness, medication use models designed to improve patient health, and effective surveillance systems to improve the safe use of medication.

I have a particular clinical interest in pediatric medicine and the variability in drug response. My labs use tools in pharmacogenomics, pharmacoepidemiology and pharmacokinetics in order to develop a systems pharmacology approach to drug problems. On the clinical side, I have an interest in the clinical management of patients who experience serious adverse drug reactions.

Another area of interest is the translation of knowledge to aid evidence-based drug policy development. POPi contributes to solving the international drug policy crisis on two levels: the public policy level (federal and provincial), and the clinical policy level. In this way the needs of government are served to manage drug budgets, the needs of clinicians to improve patient care, and the public need to understand and improve the effectiveness, safety and cost effectiveness of drugs.

Academic Affiliations

  • Professor, , Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Evidence to Innovation
  • Research Group(s): Clinical Pharmacology; Global Health and Innovations

Contact Information

Location

950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4

Pharmacogenomic testing: Enhancing personalized medication use for patients

Canadian Family Physician

Loucks, Catrina M and Groeneweg, Gabriella and Roy, Carl and Lee, David K and Rieder, Michael J and Lebel, Denis and Ito, Shinya and Ross, Colin J and Carleton, Bruce C

CYP2C9, VKORC1, and CYP4F2 polymorphisms and pediatric warfarin maintenance dose: a systematic review and meta-analysis

The pharmacogenomics journal

Takeuchi, Masanobu and Kobayashi, Tohru and Biss, Tina and Kamali, Farhad and Vear, Susan I and Ho, Richard H and Bajolle, Fanny and Loriot, Marie-Anne and Shaw, Kaitlyn and Carleton, Bruce C and Hamberg, Anna-Karin and Wadelius, Mia and Hirono, Keiichi and Taguchi, Masato and Wakamiya, Takuya and Yanagimachi, Masakatsu and Hirai, Keita and Itoh, Kunihiko and Brando, Leonardo R and Ito, Shinya

DOI: 10.1038/s41397-019-0117-x

SJS/TEN 2019: From science to translation

Journal of dermatological science

Chang, Wan-Chun and Abe, Riichiro and Anderson, Paul and Anderson, Wanpen and Ardern-Jones, Michael R and Beachkofsky, Thomas M and Belln, Teresa and Biala, Agnieszka K and Bouchard, Charles and Cavalleri, Gianpiero L and Chapman, Nicole and Chodosh, James and Choi, Hyon K and Cibotti, Ricardo R and Divito, Sherrie J and Dewar, Karen and Dehaeck, Ulrike and Etminan, Mahyar and Forbes, Diane and Fuchs, Esther and Goldman, Jennifer L and Holmes, James H and Hope, Elyse A and Hung, Shuen-Iu and Hsieh, Chia-Ling and Iovieno, Alfonso and Jagdeo, Julienne and Kim, Mee Kum and Koelle, David M and Lacouture, Mario E and Le Pallec, Sophie and Lehloenya, Rannakoe J and Lim, Robyn and Lowe, Angie and McCawley, Jean and McCawley, Julie and Micheletti, Robert G and Mockenhaupt, Maja and Niemeyer, Katie and Norcross, Michael A and Oboh, Douglas and Olteanu, Cristina and Pasieka, Helena B and Peter, Jonathan and Pirmohamed, Munir and Rieder, Michael and Saeed, Hajirah N and Shear, Neil H and Shieh, Christine and Straus, Sabine and Sukasem, Chonlaphat and Sung, Cynthia and Trubiano, Jason A and Tsou, Sheng-Ying and Ueta, Mayumi and Volpi, Simona and Wan, Chen and Wang, Hongsheng and Wang, Zhao-Qing and Weintraub, Jessica and Whale, Cindy and Wheatley, Lisa M and Whyte-Croasdaile, Sonia and Williams, Kristina B and Wright, Galen and Yeung, Sonia N and Zhou, Li and Chung, Wen-Hung and Phillips, Elizabeth J and Carleton, Bruce C

DOI: 10.1016/j.jdermsci.2020.02.003

Real-World Evidence to Assess Medication Safety or Effectiveness in Children: Systematic Review

Drugs - real world outcomes

Lasky, Tamar and Carleton, Bruce and Horton, Daniel B and Kelly, Lauren E and Bennett, Dimitri and Czaja, Angela S and Gifkins, Dina and Osokogu, Osemeke U and McMahon, Ann W

DOI: 10.1007/s40801-020-00182-y

Big Data in the Assessment of Pediatric Medication Safety

Pediatrics

McMahon, Ann W and Cooper, William O and Brown, Jeffrey S and Carleton, Bruce and Doshi-Velez, Finale and Kohane, Isaac and Goldman, Jennifer L and Hoffman, Mark A and Kamaleswaran, Rishikesan and Sakiyama, Michiyo and Sekine, Shohko and Sturkenboom, Miriam C J M and Turner, Mark A and Califf, Robert M

DOI: 10.1542/peds.2019-0562

Risk of Pathological Gambling and Impulse Control Disorders With Dopamine Agonists: A Retrospective Cohort Study

Journal of clinical psychopharmacology

Sodhi, Mohit and Etminan, Mahyar and Carleton, Bruce and Samii, Ali

DOI: 10.1097/jcp.0000000000001122

Oral Fluoroquinolones and Risk of Mitral and Aortic Regurgitation

Journal of the American College of Cardiology

Etminan, Mahyar and Sodhi, Mohit and Ganjizadeh-Zavareh, Saeed and Carleton, Bruce and Kezouh, Abbas and Brophy, James M

DOI: 10.1016/j.jacc.2019.07.035

Pharmacogenomics of Cisplatin-Induced Ototoxicity: Successes, Shortcomings, and Future Avenues of Research

Clinical pharmacology and therapeutics

Drgemller, Britt I and Wright, Galen E B and Lo, Cody and Le, Tan and Brooks, Beth and Bhavsar, Amit P and Rassekh, Shahrad R and Ross, Colin J D and Carleton, Bruce C

DOI: 10.1002/cpt.1483

Outcome Definition Influences the Relationship Between Genetic Polymorphisms of ERCC1, ERCC2, SLC22A2 and Cisplatin Nephrotoxicity in Adult Testicular Cancer Patients

Genes

Zazuli, Zulfan and Otten, Leila S and Drgemller, Britt I and Medeiros, Mara and Monzon, Jose G and Wright, Galen E B and Kollmannsberger, Christian K and Bedard, Philippe L and Chen, Zhuo and Gelmon, Karen A and McGoldrick, Nicole and Kitchlu, Abhijat and Vijverberg, Susanne J H and Masereeuw, Rosalinde and Ross, Colin J D and Liu, Geoffrey and Carleton, Bruce C and Maitland-van der Zee, Anke H

DOI: 10.3390/genes10050364

Analyses of Adverse Drug Reactions-Nationwide Active Surveillance Network: Canadian Pharmacogenomics Network for Drug Safety Database.

Journal of clinical pharmacology

Tanoshima R and Khan A and Biala AK and Trueman JN and Drgemller BI and Wright GEB and Hasbullah JS and Groeneweg GSS and Ross CJD and Carleton BC and Canadian Pharmacogenomics Network for Drug Safety Consortium

DOI: 10.1002/jcph.1336 PubMed: 30452777

11 / 2018

A comparison of the Muenster, SIOP Boston, Brock, Chang and CTCAEv4.03 ototoxicity grading scales applied to 3,799 audiograms of childhood cancer patients treated with platinum-based chemotherapy

PloS one

Clemens, E and Brooks, B and de Vries, ACH and van Grotel, M and van den Heuvel-Eibrink, MM and Carleton, B

DOI: 10.1371/journal.pone.0210646

CYP2D6 as a treatment decision aid for ER-positive non-metastatic breast cancer patients: a systematic review with accompanying clinical practice guidelines.

Breast cancer research and treatment

Drgemller BI and Wright GEB and Shih J and Monzon JG and Gelmon KA and Ross CJD and Amstutz U and Carleton BC and CPNDS Clinical Recommendations Group

DOI: 10.1007/s10549-018-5027-0 PubMed: 30411242

11 / 2018

Pharmacogenomics of Vincristine-Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy Genes.

Clinical pharmacology and therapeutics

Wright GEB and Amstutz U and Drgemller BI and Shih J and Rassekh SR and Hayden MR and Carleton BC and Ross CJD and Canadian Pharmacogenomics Network for Drug Safety Consortium

DOI: 10.1002/cpt.1179 PubMed: 29999516

07 / 2018

Morphine biotransformation genes and neonatal clinical factors predicted behaviour problems in very preterm children at 18months

EBioMedicine

Chau, Cecil M Y and Ross, Colin J D and Chau, Vann and Synnes, Anne R and Miller, Steven P and Carleton, Bruce and Grunau, Ruth E

DOI: 10.1016/j.ebiom.2019.01.042

HUME: Large-scale Detection of Causal Genetic Factors of Adverse Drug Reactions.

Bioinformatics (Oxford, England)

Mansouri M and Yuan B and Ross CJD and Carleton BC and Ester M

DOI: 10.1093/bioinformatics/bty475 PubMed: 29931042

06 / 2018

Role of Cisplatin Dose Intensity and TPMT Variation in the Development of Hearing Loss in Children.

Therapeutic drug monitoring

Siemens A and Brooks B and Rassekh SR and Meijer AJM and van den Heuvel-Eibrink MM and Xu W and Loucks CM and Ross CJD and Carleton BC and Canadian Pharmacogenomics Network for Drug Safety Consortium

DOI: 10.1097/ftd.0000000000001085 PubMed: 36917731

06 / 2023

Urinary TIMP-2*IGFBP-7 to diagnose acute kidney injury in children receiving cisplatin.

Pediatric nephrology (Berlin, Germany)

Chui H and McMahon KR and Rassekh SR and Schultz KR and Blydt-Hansen TD and Mammen C and Pinsk M and Cuvelier GDE and Carleton BC and Tsuyuki RT and Ross CJD and Devarajan P and Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Study Group

DOI: 10.1007/s00467-023-06007-8 PubMed: 37365422

06 / 2023

Optimizing therapeutic decision-making for off-label medicines use: A scoping review and consensus recommendations for improving practice and research.

Pharmacoepidemiology and drug safety

Gazarian M and Horton DB and Carleton B and Kinlaw AC and Bushnell GA and Czaja AS and Durrieu G and Gorman EF and Titievsky L and Zito J and Slaughter JL and dosReis S

DOI: 10.1002/pds.5640 PubMed: 37208845

05 / 2023

Benefits v. risks of COVID-19 vaccination: an examination of vaccination policy impact on the occurrence of myocarditis and pericarditis.

The Lancet regional health. Western Pacific

Carleton BC and Salmon DA and Ip P and Wong ICK and Lai FTT

DOI: 10.1016/j.lanwpc.2023.100797 PubMed: 37360870

05 / 2023

Which children are still dying from asthma? A 13 year review of pediatric asthma deaths in British Columbia, Canada.

Pediatric pulmonology

Cook VE and Seear M and Carleton B and Yang CL

DOI: 10.1002/ppul.26441 PubMed: 37133221

05 / 2023

Reply: Misidentified Dopamine Agonists Undermine Investigation Into Aripiprazole Link With Impulse Control Disorders.

Journal of clinical psychopharmacology

Etminan M and Sodhi M and Carleton B

DOI: 10.1097/jcp.0000000000001675 PubMed: 36821462

03 / 2023

RBL2 Regulates Cardiac Sensitivity to Anthracycline Chemotherapy.

JACC. CardioOncology

Xia P and Chen J and Sapkota Y and Scott EN and Liu Y and Hudson MM and Rassekh SR and Carleton BC and Ross CJD and Chow EJ and Cheng Z

DOI: 10.1016/j.jaccao.2022.10.017 PubMed: 37397090

03 / 2023

Vaccinomics: A scoping review.

Vaccine

Dudley MZ and Gerber JE and Budigan Ni H and Blunt M and Holroyd TA and Carleton BC and Poland GA and Salmon DA

DOI: 10.1016/j.vaccine.2023.02.009 PubMed: 36803903

02 / 2023

Development of a Dose-Adjusted Polygenic Risk Model for Anthracycline-Induced Cardiotoxicity.

Therapeutic drug monitoring

Siemens A and Rassekh SR and Ross CJD and Carleton BC

DOI: 10.1097/ftd.0000000000001077 PubMed: 36728273

01 / 2023

Noninvasive testing for mycophenolate exposure in children with renal transplant using urinary metabolomics.

Pediatric transplantation

Taha K and Sharma A and Kroeker K and Ross C and Carleton B and Wishart D and Medeiros M and Blydt-Hansen TD

DOI: 10.1111/petr.14460 PubMed: 36582125

12 / 2022

All-trans retinoic acid (ATRA) regulates key genes in the RARG-TOP2B pathway and reduces anthracycline-induced cardiotoxicity.

PloS one

Hasbullah JS and Scott EN and Bhavsar AP and Gunaretnam EP and Miao F and Soliman H and Carleton BC and Ross CJD

DOI: 10.1371/journal.pone.0276541 PubMed: 36331922

11 / 2022

Acute kidney injury during cisplatin therapy and associations with kidney outcomes 2 to 6months post-cisplatin in children: a multi-centre, prospective observational study.

Pediatric nephrology (Berlin, Germany)

McMahon KR and Lebel A and Rassekh SR and Schultz KR and Blydt-Hansen TD and Cuvelier GDE and Mammen C and Pinsk M and Carleton BC and Tsuyuki RT and Ross CJD and Huynh L and Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Study Group

DOI: 10.1007/s00467-022-05745-5 PubMed: 36260162

10 / 2022

The Canadian Mother-Child Cohort Active Surveillance Initiative (CAMCCO): Comparisons between Quebec, Manitoba, Saskatchewan, and Alberta.

PloS one

Brard A and Kaul P and Eltonsy S and Winquist B and Chateau D and Hawken S and Sprague A and Walker M and Bernatsky S and Abrahamowicz M and Soares de Moura C and Vinet and Savu A

DOI: 10.1371/journal.pone.0274355 PubMed: 36126025

09 / 2022

A Systematic Review of Polygenic Models for Predicting Drug Outcomes

Journal of Personalized Medicine

Angela Siemens and Spencer Anderson and Shahrad Rod Rassekh and Colin J. D. Ross and Bruce C. Carleton

DOI: 10.3390/jpm12091394

08 / 2022

Advancing the Science of Vaccine Safety During the Coronavirus Disease 2019 (COVID-19) Pandemic and Beyond: Launching an International Network of Special Immunization Services.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Top KA and Chen RT and Levy O and Ozonoff A and Carleton B and Crawford NW and Creech CB and Kochhar S and Poland GA and Gutu K and Cutland CL

DOI: 10.1093/cid/ciac407 PubMed: 35680552

08 / 2022

Paediatric oral formulations: Why don't our kids have the medicines they need?

British journal of clinical pharmacology

Jurez-Hernndez JE and Carleton BC

DOI: 10.1111/bcp.15456 PubMed: 35803881

07 / 2022

Pharmacogenetic testing in pediatric neurology: a pragmatic study evaluating clinician and patient perceptions.

Personalized medicine

Ppin MA and Otis AS and Tremblay Z and Boul M and Lebel D and Major P and Lortie A and Pinchefsky E and Rossignol E and Carleton B and Bussires JF and Mtras M

DOI: 10.2217/pme-2021-0150 PubMed: 35830229

07 / 2022

Cisplatin-induced nephrotoxicity in childhood cancer: comparison between two countries.

Pediatric nephrology (Berlin, Germany)

Zazuli Z and Op 't Hoog CJP and Vijverberg SJH and Masereeuw R and Rassekh SR and Medeiros M and Rivas-Ruiz R and Maitland-van der Zee AH and Carleton BC

DOI: 10.1007/s00467-022-05632-z PubMed: 35748941

06 / 2022

Editorial: Real-World Evidence of Pediatric Exposure to Psychopharmacologic Medications.

Frontiers in psychiatry

Zito JM and DosReis S and Carleton B

DOI: 10.3389/fpsyt.2022.930276 PubMed: 35757208

06 / 2022

Quantifying the intensity of adverse events with ibuprofen and oxycodone: an observational cohort study.

BMJ paediatrics open

Ali S and Gourlay K and Yukseloglu A and Rosychuk RJ and Ortiz S and Watts R and Johnson DW and Carleton B and Le May S and Drendel AL

DOI: 10.1136/bmjpo-2022-001428 PubMed: 36053661

05 / 2022

Pharmacogenomic testing in paediatrics: Clinical implementation strategies.

British journal of clinical pharmacology

Barker CIS and Groeneweg G and Maitland-van der Zee AH and Rieder MJ and Hawcutt DB and Hubbard TJ and Swen JJ and Carleton BC

DOI: 10.1111/bcp.15181 PubMed: 34907575

02 / 2022

A pharmacogenomic investigation of the cardiac safety profile of ondansetron in children and pregnant women.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Drgemller BI and Wright GEB and Trueman J and Shaw K and Staub M and Chaudhry S and Miao F and Higginson M and Groeneweg GSS and Brown J and Magee LA and Whyte SD and West N and Carleton BC

DOI: 10.1016/j.biopha.2022.112684 PubMed: 35149390

02 / 2022

Pharmacogenomic study of anthracycline-induced cardiotoxicity in Mexican pediatric patients.

Pharmacogenomics

Vargas-Neri JL and Carleton B and Ross CJ and Medeiros M and Castaeda-Hernndez G and Clark P

DOI: 10.2217/pgs-2021-0144 PubMed: 35147047

02 / 2022

Patient-specific genetic factors predict treatment failure in sofosbuvir-treated patients with chronic hepatitis C.

Liver international : official journal of the International Association for the Study of the Liver

Loucks CM and Lin JJ and Trueman JN and Drgemller BI and Wright GEB and Chang WC and Li KH and Yoshida EM and Ford JA and Lee SS and Crotty P and Kim RB and Al-Judaibi B and Schwarz UI and Carleton BC

DOI: 10.1111/liv.15175 PubMed: 35107877

02 / 2022

Hydroxyzine Use in Preschool Children and Its Effect on Neurodevelopment: A Population-Based Longitudinal Study.

Frontiers in psychiatry

Gober HJ and Li KH and Yan K and Bailey AJ and Carleton BC

DOI: 10.3389/fpsyt.2021.721875 PubMed: 35153845

01 / 2022

Association between Genetic Variants and Cisplatin-Induced Nephrotoxicity: A Genome-Wide Approach and Validation Study

Journal of Personalized Medicine

Zulfan Zazuli and Corine de Jong and Wei Xu and Susanne J. H. Vijverberg and Rosalinde Masereeuw and Devalben Patel and Maryam Mirshams and Khaleeq Khan and Dangxiao Cheng and Bayardo Ordonez-Perez and Shaohui Huang and Anna Spreafico and Aaron R. Hansen and David P. Goldstein and John R. de Almeida and Scott V. Bratman and Andrew Hope and Jennifer J. Knox and Rebecca K. S. Wong and Gail E. Darling and Abhijat Kitchlu and Simone W. A. van Haarlem and Femke van der Meer and Anne S. R. van Lindert and Alexandra ten Heuvel and Jan Brouwer and Colin Ross and Bruce C. Carleton and Toine Egberts and Gerarda J. M. Herder and Vera H. M. Deneer and Anke Maitland-van der Zee and Geoffrey Liu

DOI: 10.3390/jpm11111233

11 / 2021

Prevalence and risk factors for cisplatin-induced hearing loss in children, adolescents, and young adults: a multi-institutional North American cohort study.

The Lancet. Child & adolescent health

Moke DJ and Luo C and Millstein J and Knight KR and Rassekh SR and Brooks B and Ross CJD and Wright M and Mena V and Rushing T and Esbenshade AJ and Carleton BC and Orgel E

DOI: 10.1016/s2352-4642(21)00020-1 PubMed: 33581749

02 / 2021

Guillain-Barr Syndrome Following Influenza Vaccines Affords Opportunity to Improve Vaccine Confidence.

The Journal of infectious diseases

Salmon DA and Dudley MZ and Carleton BC

DOI: 10.1093/infdis/jiaa544 PubMed: 33137189

02 / 2021

Challenges and Opportunities in Implementing Pharmacogenetic Testing in Clinical Settings.

Annual review of pharmacology and toxicology

Chang WC and Tanoshima R and Ross CJD and Carleton BC

DOI: 10.1146/annurev-pharmtox-030920-025745 PubMed: 33006916

10 / 2020

Pharmacokinetic-Pharmacogenomic Model for Chinese Children Treated With Lamotrigine Also Applies for Mexican Children.

Therapeutic drug monitoring

Jurez-Hernndez JE and Gutirrez-Ceniceros M and Gonzlez-Ramrez JR and Medeiros M and Carleton B and Ross C and Castaeda-Hernndez G

DOI: 10.1097/ftd.0000000000000792 PubMed: 32694359

10 / 2020

Correction: Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritization.

The pharmacogenomics journal

King C and McKenna A and Farzan N and Vijverberg SJ and van der Schee MP and Maitland-van der Zee AH and Arianto L and Bisgaard H and Bnnelykke K and Berce V and PotoCnik U and Hawcutt DB

DOI: 10.1038/s41397-020-0178-x PubMed: 32704026

10 / 2020

Prevention of adverse drug effects: a pharmacogenomic approach.

Current opinion in pediatrics

Scott EN and Hasbullah JS and Carleton BC and Ross CJD

DOI: 10.1097/mop.0000000000000935 PubMed: 32796162

10 / 2020

Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy.

Annual review of pharmacology and toxicology

Elzagallaai AA and Carleton BC and Rieder MJ

DOI: 10.1146/annurev-pharmtox-031320-104151 PubMed: 32976737

09 / 2020

Pseudotumor cerebri syndrome with different types of hormonal contraceptives in women of child-bearing age.

European journal of neurology

Etminan M and Khosrow-Khavar F and Sodhi M and Carleton B and Magee LA and Tremlett H and Kezouh A and Sheldon C

DOI: 10.1111/ene.14480 PubMed: 32810878

09 / 2020

Les tests pharmacognomiques: Amliorer le recours personnalis aux mdicaments pour les patients

Canadian family physician Medecin de famille canadien

Loucks, Catrina M and Groeneweg, Gabriella and Roy, Carl and Lee, David K and Rieder, Michael J and Lebel, Denis and Ito, Shinya and Ross, Colin J and Carleton, Bruce C

Vincristine-induced peripheral neurotoxicity: A prospective cohort

Pediatric hematology and oncology

Nama, Nassr and Barker, Mikaela K and Kwan, Celia and Sabarre, Cheryl and Solimano, Veronica and Rankin, Anne and Raabe, Jennifer and Ross, Colin J and Carleton, Bruce and Zwicker, Jill G and Rassekh, Shahrad Rod

DOI: 10.1080/08880018.2019.1677832

Does Ibuprofen Worsen COVID-19?

Drug safety

Moore, Nicholas and Carleton, Bruce and Blin, Patrick and Bosco-Levy, Pauline and Droz, Cecile

DOI: 10.1007/s40264-020-00953-0

An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects

Expert opinion on drug metabolism & toxicology

Chang, Wan-Chun and Hung, Shuen-Iu and Carleton, Bruce and Chung, Wen-Hung

DOI: 10.1080/17425255.2020.1780209

Epidemiologic Characteristics of Acute Kidney Injury During Cisplatin Infusions in Children Treated for Cancer

JAMA network open

McMahon, Kelly R and Rassekh, Shahrad Rod and Schultz, Kirk R and Blydt-Hansen, Tom and Cuvelier, Geoffrey D E and Mammen, Cherry and Pinsk, Maury and Carleton, Bruce C and Tsuyuki, Ross T and Ross, Colin J D and Palijan, Ana and Huynh, Louis and Yordanova, Mariya and Crpeau-Hubert, Frdrik and Wang, Stella and Boyko, Debbie and Zappitelli, Michael and {Applying Biomarkers to Minimize Long-term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Study Group}

DOI: 10.1001/jamanetworkopen.2020.3639

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

The pharmacogenomics journal

King, Charlotte and McKenna, Amanda and Farzan, Niloufar and Vijverberg, Susanne J and van der Schee, Marc P and Maitland-van der Zee, Anke H and Arianto, Lambang and Bisgaard, Hans and Bnnelykke, Klaus and Berce, Vojko and Potocnik, Uro and Repnik, Katja and Carleton, Bruce and Daley, Denise and Chew, Fook Tim and Chiang, Wen Chin and Sio, Yang Yie and Cloutier, Michelle M and Den Dekker, Herman T and Duijts, Liesbeth and de Jongste, Johan C and Dijk, F Nicole and Koppelman, Gerard H and Flores, Carlos and Hernandez-Pacheco, Natalia and Pino-Yanes, Maria and Mukhopadhyay, Somnath and Basu, Kaninika and Bignell, Lauren and Tantisira, Kelan G and Turner, Steve and Verhamme, Katia M and Francis, Ben and Pirmohamed, Munir and Sinha, Ian and Hawcutt, Daniel B

DOI: 10.1038/s41397-019-0140-y

Risk of Gynecomastia with Users of Proton Pump Inhibitors

Pharmacotherapy

He, Bonnie and Carleton, Bruce and Etminan, Mahyar

DOI: 10.1002/phar.2245

Considerations for Implementing Precision Therapeutics for Children

Clinical and translational science

McLaughlin, Matthew J and Wagner, Jonathan and Shakhnovich, Valentina and Carleton, Bruce and Leeder, J Steven

DOI: 10.1111/cts.12607

Genetic Determinants of Ototoxicity During and After Childhood Cancer Treatment: Protocol for the PanCareLIFE Study

JMIR research protocols

Clemens, Eva and Meijer, Annelot Jm and Broer, Linda and Langer, Thorsten and van der Kooi, Anne-Lotte Lf and Uitterlinden, Andr G and de Vries, Andrica and Kuehni, Claudia E and Garr, Maria L and Garr, Maria L and Kepak, Tomas and Kruseova, Jarmila and Winther, Jeanette F and Kremer, Leontien C and van Dulmen-den Broeder, Eline and Tissing, Wim Je and Rechnitzer, Catherine and Kenborg, Line and Hasle, Henrik and Grabow, Desiree and Parfitt, Ross and Binder, Harald and Carleton, Bruce C and Byrne, Julianne and Kaatsch, Peter and Am Zehnhoff-Dinnesen, Antoinette and Zolk, Oliver and van den Heuvel-Eibrink, Marry M

DOI: 10.2196/11868

Drs. He etal. Reply to Drs. Lai and Brown

Pharmacotherapy

He, Bonnie and Carleton, Bruce and Etminan, Mahyar

DOI: 10.1002/phar.2274

Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium

The Lancet. Oncology

Clemens, Eva and van den Heuvel-Eibrink, Marry M and Mulder, Rene L and Kremer, Leontien C M and Hudson, Melissa M and Skinner, Roderick and Constine, Louis S and Bass, Johnnie K and Kuehni, Claudia E and Langer, Thorsten and van Dalen, Elvira C and Bardi, Edith and Bonne, Nicolas-Xavier and Brock, Penelope R and Brooks, Beth and Carleton, Bruce and Caron, Eric and Chang, Kay W and Johnston, Karen and Knight, Kristin and Nathan, Paul C and Orgel, Etan and Prasad, Pinki K and Rottenberg, Jan and Scheinemann, Katrin and de Vries, Andrica C H and Walwyn, Thomas and Weiss, Annette and Am Zehnhoff-Dinnesen, Antoinette and Cohn, Richard J and Landier, Wendy and {International Guideline Harmonization Group ototoxicity group}

DOI: 10.1016/s1470-2045(18)30858-1

Association of Gabapentin or Pregabalin Use and Incidence of Acute Angle-closure Glaucoma

Journal of glaucoma

Browne, Mitchell J and Zakrzewski, Helena and Carleton, Bruce and Etminan, Mahyar and Mikelberg, Frederick S

DOI: 10.1097/ijg.0000000000001330

Genome-Wide Association Studies of Drug-Induced Liver Injury Make Progress Beyond the HLA Region

Gastroenterology

Wright, Galen E B and Drgemller, Britt I and Ross, Colin J D and Carleton, Bruce C

DOI: 10.1053/j.gastro.2019.03.076

Direct-Acting Antivirals for Hepatitis C: Predictors of Early Discontinuation in the Real World

Journal of managed care & specialty pharmacy

de vila Machado, Marina Amaral and de Moura, Cristiano Soares and Klein, Marina and Winthrop, Kevin and Carleton, Bruce and Abrahamowicz, Michal and Feld, Jordan and Curtis, Jeffrey R and Beauchamp, Marie-Eve and Bernatsky, Sasha

DOI: 10.18553/jmcp.2019.25.6.697

The incidence of symptomatic osteonecrosis after allogeneic haematopoietic stem cell transplantation in children with acute lymphoblastic leukaemia - controversy on dexamethasone as a risk factor.

British journal of haematology

Tanoshima R and Carleton BC

DOI: 10.1111/bjh.15657 PubMed: 30408145

11 / 2018

Incidence rates of narcolepsy diagnoses in Taiwan, Canada, and Europe: The use of statistical simulation to evaluate methods for the rapid assessment of potential safety issues on a population level in the SOMNIA study.

PloS one

Dodd CN and de Ridder M and Huang WT and Weibel D and Giner-Soriano M and Perez-Vilar S and Diez-Domingo J and Svenson LW and Mahmud SM and Carleton B and Naus M and Kwong JC and Sturkenboom M

DOI: 10.1371/journal.pone.0204799 PubMed: 30332477

10 / 2018

Antipsychotic-Associated Symptoms of Tourette Syndrome: A Systematic Review.

CNS drugs

Kim DD and Barr AM and Chung Y and Yuen JWY and Etminan M and Carleton BC and White RF and Honer WG and Procyshyn RM

DOI: 10.1007/s40263-018-0559-8 PubMed: 30121819

10 / 2018

Genetic Variations and Cisplatin Nephrotoxicity: A Systematic Review.

Frontiers in pharmacology

Zazuli Z and Vijverberg S and Slob E and Liu G and Carleton B and Veltman J and Baas P and Masereeuw R and Maitland-van der Zee AH

DOI: 10.3389/fphar.2018.01111 PubMed: 30319427

09 / 2018

Oral fluoroquinolones and risk of fibromyalgia.

British journal of clinical pharmacology

Ganjizadeh-Zavareh S and Sodhi M and Spangehl T and Carleton B and Etminan M

DOI: 10.1111/bcp.13765 PubMed: 30216492

09 / 2018

Reducing anthracycline-induced cardiotoxicity through pharmacogenetics.

Pharmacogenomics

Scott E and Hasbullah JS and Ross CJ and Carleton BC

DOI: 10.2217/pgs-2018-0124 PubMed: 30213233

09 / 2018

Tumor necrosis factor inhibitors and risk of peripheral neuropathy in patients with rheumatic diseases.

Seminars in arthritis and rheumatism

Etminan M and Sodhi M and Samii A and Carleton BC and Kezouh A and Antonio Avina-Zubieta J

DOI: 10.1016/j.semarthrit.2018.09.006 PubMed: 30337056

09 / 2018

Narcolepsy and adjuvanted pandemic influenza A (H1N1) 2009 vaccines - Multi-country assessment.

Vaccine

Weibel D and Sturkenboom M and Black S and de Ridder M and Dodd C and Bonhoeffer J and Vanrolleghem A and van der Maas N and Lammers GJ and Overeem S and Gentile A and Giglio N and Shimabukuro TT

DOI: 10.1016/j.vaccine.2018.08.008 PubMed: 30122647

08 / 2018

In Reply to Controversies on the Use of Glaucoma Medications During Surgery.

Journal of glaucoma

Wendel C and Zakrzewski H and Carleton B and Etminan M and Mikelberg FS

DOI: 10.1097/ijg.0000000000001074 PubMed: 30180014

08 / 2018

Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study.

Journal of clinical psychopharmacology

Guo MY and Etminan M and Procyshyn RM and Kim DD and Samii A and Kezouh A and Carleton BC

DOI: 10.1097/jcp.0000000000000911 PubMed: 29901567

08 / 2018

Statin medications and the risk of gynecomastia.

Clinical endocrinology

Skeldon SC and Carleton B and Brophy JM and Sodhi M and Etminan M

DOI: 10.1111/cen.13794 PubMed: 29923212

07 / 2018

Common variation near IRF6 is associated with IFN--induced liver injury in multiple sclerosis.

Nature genetics

Kowalec K and Wright GEB and Drgemller BI and Aminkeng F and Bhavsar AP and Kingwell E and Yoshida EM and Traboulsee A and Marrie RA and Kremenchutzky M and Campbell TL and Carleton BC

DOI: 10.1038/s41588-018-0168-y PubMed: 30013178

07 / 2018

Activated protein C as disease-modifying therapy in antenatal preeclampsia: An open-label, single arm safety and efficacy trial.

Pregnancy hypertension

von Dadelszen P and Magee LA and Benton SJ and Hu Y and Ansermino JM and Carleton B and Carter C and Douglas MJ and Janssen PA and Lee SK and Leung PCK and Li J and MacNab Y and Payne BA and Russell JA

DOI: 10.1016/j.preghy.2018.05.009 PubMed: 30177038

05 / 2018

Oral Fluoroquinolone Prescribing to Children in the United States From 2006 to 2015.

The Pediatric infectious disease journal

Etminan M and Guo M and Carleton B

DOI: 10.1097/inf.0000000000002121 PubMed: 29846302

05 / 2018

Assessment of hair cortisol as a potential biomarker for possible adrenal suppression due to inhaled corticosteroid use in children with asthma: A retrospective observational study.

Clinical biochemistry

Smy L and Shaw K and Amstutz U and Staub M and Chaudhry S and Smith A and Carleton B and Koren G

DOI: 10.1016/j.clinbiochem.2018.04.006 PubMed: 29673814

04 / 2018

Response to The routine use of oral steroids in paediatric asthma is not routine.

Paediatrics & child health

Smith N and Wang A and Shaw K and Groeneweg G and Goldman RD and Wilkinson B and Jimenez R and Mwai L and Carleton B

DOI: 10.1093/pch/pxy006 PubMed: 29769812

04 / 2018

The influence of genetic variation on late toxicities in childhood cancer survivors: A review.

Critical reviews in oncology/hematology

Clemens E and van der Kooi ALF and Broer L and van Dulmen-den Broeder E and Visscher H and Kremer L and Tissing W and Loonen J and Ronckers CM and Pluijm SMF and Neggers SJCMM and van den Heuvel-Eibrink MM

DOI: 10.1016/j.critrevonc.2018.04.001 PubMed: 29759558

04 / 2018

Risk of Anterior Segment Complications Associated With the Live Herpes Zoster Vaccine: Evidence From a Health-Claim Database.

Cornea

Liu RT and Yeung SN and Carleton B and Etminan M

DOI: 10.1097/ico.0000000000001595 PubMed: 29601366

03 / 2018

Association of Post-operative Topical Prostaglandin Analog or Beta-blocker Use and Incidence of Pseudophakic Cystoid Macular Edema.

Journal of glaucoma

Wendel C and Zakrzewski H and Carleton B and Etminan M and Mikelberg FS

DOI: 10.1097/ijg.0000000000000929 PubMed: 29505438

03 / 2018

An initial health economic evaluation of pharmacogenomic testing in patients treated for childhood cancer with anthracyclines.

Pediatric blood & cancer

Dionne F and Aminkeng F and Bhavsar AP and Groeneweg G and Smith A and Visscher H and Rassekh SR and Ross C and Carleton B

DOI: 10.1002/pbc.26887 PubMed: 29271558

03 / 2018

Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update.

Clinical pharmacology and therapeutics

Phillips EJ and Sukasem C and Whirl-Carrillo M and Mller DJ and Dunnenberger HM and Chantratita W and Goldspiel B and Chen YT and Carleton BC and George AL and Mushiroda T and Pirmohamed M

DOI: 10.1002/cpt.1004 PubMed: 29392710

02 / 2018

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.

Neurology

McCormack M and Gui H and Ingason A and Speed D and Wright GEB and Zhang EJ and Secolin R and Yasuda C and Kwok M and Wolking S and Becker F and Rau S and Avbersek A and Heggeli K and Leu C and Cavalleri GL

DOI: 10.1212/wnl.0000000000004853 PubMed: 29288229

01 / 2018

Further investigation of the role of ACYP2 and WFS1 pharmacogenomic variants in the development of cisplatin-induced ototoxicity in testicular cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research

Drgemller BI and Brooks B and Monzon JG and Wright GE and Liu G and Renouf DJ and Kollmannsberger C and Bedard PL and Hayden MR and Gelmon KA and Carleton B and Ross CJ

DOI: 10.1158/1078-0432.ccr-17-2810 PubMed: 29358504

01 / 2018

Risk of hair loss with different antidepressants: a comparative retrospective cohort study.

International clinical psychopharmacology

Etminan M and Sodhi M and Procyshyn RM and Guo M and Carleton BC

DOI: 10.1097/yic.0000000000000191 PubMed: 28763345

01 / 2018

SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation.

The journal of allergy and clinical immunology. In practice

White KD and Abe R and Ardern-Jones M and Beachkofsky T and Bouchard C and Carleton B and Chodosh J and Cibotti R and Davis R and Denny JC and Dodiuk-Gad RP and Ergen EN and Goldman JL and Phillips EJ

DOI: 10.1016/j.jaip.2017.11.023 PubMed: 29310768

Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer.

JAMA oncology

Drgemller BI and Monzon JG and Bhavsar AP and Borrie AE and Brooks B and Wright GEB and Liu G and Renouf DJ and Kollmannsberger CK and Bedard PL and Aminkeng F and Amstutz U and Carleton BC

DOI: 10.1001/jamaoncol.2017.0502 PubMed: 28448657

11 / 2017

Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.

PM & R : the journal of injury, function, and rehabilitation

McLaughlin MJ and He Y and Brunstrom-Hernandez J and Thio LL and Carleton BC and Ross CJD and Gaedigk A and Lewandowski A and Dai H and Jusko WJ and Leeder JS

DOI: 10.1016/j.pmrj.2017.08.441 PubMed: 28867665

09 / 2017

Dentists Prescribing of Analgesics for Children in British Columbia, Canada

Journal (Canadian Dental Association)

Etminan M and Nouri MR and Sodhi M and Carleton BC

PubMed: 29360020

08 / 2017

Oral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome: Nested case-control study.

Neurology

Sodhi M and Sheldon CA and Carleton B and Etminan M

DOI: 10.1212/wnl.0000000000004247 PubMed: 28754842

08 / 2017

Fluoroquinolone Use and Risk of Carpal Tunnel Syndrome: A Pharmacoepidemiologic Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Cheng JZ and Sodhi M and Etminan M and Carleton BC

DOI: 10.1093/cid/cix362 PubMed: 28444196

08 / 2017

Improved strength on 5-hydroxytryptophan and carbidopa in spinal cord atrophy.

Journal of the neurological sciences

Horvath GA and Meisner L and Selby K and Stowe R and Carleton B

DOI: 10.1016/j.jns.2017.04.047 PubMed: 28566180

07 / 2017

Physician and parent barriers to the use of oral corticosteroids for the prevention of paediatric URTI-induced acute asthma exacerbations at home.

Paediatrics & child health

Smith N and Smith A and Wang A and Shaw K and Groeneweg G and Goldman RD and Wilkinson B and Jimenez R and Mwai L and Carleton B

DOI: 10.1093/pch/pxx047 PubMed: 29479212

07 / 2017

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium.

Pharmacogenomics

Farzan N and Vijverberg SJ and Andiappan AK and Arianto L and Berce V and Blanca-Lpez N and Bisgaard H and Bnnelykke K and Burchard EG and Campo P and Canino G and Carleton B and Maitland-van der Zee AH

DOI: 10.2217/pgs-2017-0035 PubMed: 28639505

07 / 2017

Application of pharmacogenomics to investigate adverse drug reactions to the disease-modifying treatments for multiple sclerosis: a case-control study protocol for dimethyl fumarate-induced lymphopenia.

BMJ open

Kowalec K and Kingwell E and Carruthers R and Marrie RA and Bernatsky S and Traboulsee A and Ross CJD and Carleton B and Tremlett H

DOI: 10.1136/bmjopen-2017-016276 PubMed: 28576902

06 / 2017

Pharmacogenomic screening for anthracycline-induced cardiotoxicity in childhood cancer.

British journal of clinical pharmacology

Aminkeng F and Ross CJD and Rassekh SR and Rieder MJ and Bhavsar AP and Sanatani S and Bernstein D and Hayden MR and Amstutz U and Carleton BC

DOI: 10.1111/bcp.13218 PubMed: 28317142

05 / 2017

Association of Repeated Intravitreous Bevacizumab Injections With Risk for Glaucoma Surgery.

JAMA ophthalmology

Eadie BD and Etminan M and Carleton BC and Maberley DA and Mikelberg FS

DOI: 10.1001/jamaophthalmol.2017.0059 PubMed: 28301639

04 / 2017

Design and Methods of the Pan-Canadian Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Nephrotoxicity Study: A Prospective Observational Cohort Study.

Canadian journal of kidney health and disease

McMahon KR and Rod Rassekh S and Schultz KR and Pinsk M and Blydt-Hansen T and Mammen C and Tsuyuki RT and Devarajan P and Cuvelier GD and Mitchell LG and Baruchel S and Palijan A and Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Group

DOI: 10.1177/2054358117690338 PubMed: 28270931

Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines.

PloS one

Bhavsar AP and Gunaretnam EP and Li Y and Hasbullah JS and Carleton BC and Ross CJ

DOI: 10.1371/journal.pone.0175711 PubMed: 28406961

Risk of Gambling Disorder and Impulse Control Disorder With Aripiprazole, Pramipexole, and Ropinirole: A Pharmacoepidemiologic Study.

Etminan M and Sodhi M and Samii A and Procyshyn RM and Guo M and Carleton BC

PubMed: 27930495

12 / 2016

The global spectrum of protein-coding pharmacogenomic diversity.

Wright GE and Carleton B and Hayden MR and Ross CJ

DOI: 10.1038/tpj.2016.77 PubMed: 27779249

10 / 2016

Risk of Extrapyramidal Adverse Events With Aripiprazole.

Etminan M and Procyshyn RM and Samii A and Carleton BC

DOI: 10.1097/jcp.0000000000000543 PubMed: 27580493

10 / 2016

Oral morphine dosing predictions based on single dose in healthy children undergoing surgery.

Dawes JM and Cooke EM and Hannam JA and Brand KA and Winton P and Jimenez-Mendez R and Aleksa K and Lauder GR and Carleton BC and Koren G and Rieder MJ and Anderson BJ and Montgomery CJ

DOI: 10.1111/pan.13020 PubMed: 27779356

10 / 2016

Risk of sensorineural hearing loss with macrolide antibiotics: A nested case-control study.

Etminan M and Westerberg BD and Kozak FK and Guo MY and Carleton BC

PubMed: 27497265

08 / 2016

Asthma in British Columbia: Are We Finally Breathing Easier? A population based study of the burden of disease Over 14Years.

Bardal S and Smith A and Luo HA and Zhang T and Groeneweg G and Jimenez Mendez R and Goldman R and Carleton B

PubMed: 27414432

07 / 2016

An in silico framework for integrating epidemiologic and genetic evidence with health care applications: ventilation-related pneumothorax as a case illustration.

Torosyan Y and Hu Y and Hoffman S and Luo Q and Carleton B and Marinac-Dabic D

DOI: 10.1093/jamia/ocw031 PubMed: 27107435

07 / 2016

Pharmacogenomics in Pediatric Patients: Towards Personalized Medicine.

Maagdenberg H and Vijverberg SJ and Bierings MB and Carleton BC and Arets HG and de Boer A and Maitland-van der Zee AH

PubMed: 27142473

05 / 2016

Recommendations for Genetic Testing to Reduce the Incidence of Anthracycline-induced Cardiotoxicity.

Aminkeng F and Ross CJ and Rassekh SR and Hwang S and Rieder MJ and Bhavsar AP and Smith A and Sanatani S and Gelmon KA and Bernstein D and Hayden MR and Amstutz U and Carleton BC and CPNDS Clinical Practice Recommendations Group

DOI: 10.1111/bcp.13008 PubMed: 27197003

05 / 2016

Risk of Myocardial Infarction and Stroke With Single or Repeated Doses of Intravitreal Bevacizumab in Age-Related Macular Degeneration.

Etminan M and Maberley DA and Babiuk DW and Carleton BC

DOI: 10.1016/j.ajo.2015.11.030 PubMed: 26701272

03 / 2016

Clinical Practice Recommendations For The Management And Prevention Of Cisplatin-Induced Hearing Loss Using Pharmacogenetic Markers.

Lee JW and Pussegoda K and Rassekh RS and Monzon JG and Liu G and Hwang S and Bhavsar AP and Pritchard S and Ross CJ and Amstutz U and Carleton BC and CPNDS clinical recommendations group

PubMed: 26960170

03 / 2016

Genetic diversity of variants involved in drug response and metabolism in Sri Lankan populations: implications for clinical implementation of pharmacogenomics.

Chan SL and Samaranayake N and Ross CJ and Toh MT and Carleton B and Hayden MR and Teo YY and Dissanayake VH and Brunham LR

DOI: 10.1097/FPC.0000000000000182 PubMed: 26444257

01 / 2016

Hair cortisol as a hypothalamic-pituitary-adrenal axis biomarker in pregnant women with asthma: a retrospective observational study.

Smy L and Shaw K and Amstutz U and Smith A and Berger H and Carleton B and Koren G

DOI: 10.1186/s12884-016-0962-4 PubMed: 27440139

Risperidone and Risk of Gynecomastia in Young Men.

Etminan M and Carleton B and Brophy JM

DOI: 10.1089/cap.2015.0024 PubMed: 26287371

11 / 2015

A Compartmental Analysis for Morphine and Its Metabolites in Young Children After a Single Oral Dose.

Velez de Mendizabal N and Jimenez-Mendez R and Cooke E and Montgomery CJ and Dawes J and Rieder MJ and Aleksa K and Koren G and Jacobo-Cabral CO and Gonzalez-Ramirez R and Castaeda-Hernandez G and Carleton BC

DOI: 10.1007/s40262-015-0256-4 PubMed: 25773480

10 / 2015

The pharmacogenetics of codeine pain relief in the postpartum period.

Baber M and Chaudhry S and Kelly L and Ross C and Carleton B and Berger H and Koren G

DOI: 10.1038/tpj.2015.3 PubMed: 25752520

10 / 2015

A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.

Aminkeng F and Bhavsar AP and Visscher H and Rassekh SR and Li Y and Lee JW and Brunham LR and Caron HN and van Dalen EC and Kremer LC and van der Pal HJ and Amstutz U and Rieder MJ and Bernstein D and Carleton BC and Hayden MR and Ross CJ and Canadian Pharmacogenomics Network for Drug Safety Consortium

DOI: 10.1038/ng.3374 PubMed: 26237429

09 / 2015

Cisplatin Nephrotoxicity and Longitudinal Growth in Children With Solid Tumors: A Retrospective Cohort Study.

Jimnez-Triana CA and Casteln-Martnez OD and Rivas-Ruiz R and Jimnez-Mndez R and Medina A and Clark P and Rassekh R and Castaeda-Hernndez G and Carleton B and Medeiros M and Canadian Pharmacogenomics Network for Drug Safety Consortium

DOI: 10.1097/MD.0000000000001413 PubMed: 26313789

08 / 2015

Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy.

Shaw K and Amstutz U and Kim RB and Lesko LJ and Turgeon J and Michaud V and Hwang S and Ito S and Ross C and Carleton BC and CPNDS Clinical Recommendation Group

DOI: 10.1097/FTD.0000000000000192 PubMed: 26186657

08 / 2015

Hair cortisol as a novel biomarker of HPA suppression by inhaled corticosteroids in children.

Smy L and Shaw K and Smith A and Russell E and Van Uum S and Rieder M and Carleton B and Koren G

DOI: 10.1038/pr.2015.60 PubMed: 25790275

07 / 2015

Association between regulatory advisories and codeine prescribing to postpartum women.

Smolina K and Weymann D and Morgan S and Ross C and Carleton B

DOI: 10.1001/jama.2015.3642 PubMed: 25965237

05 / 2015

Post-renal transplant erythrocytosis: a case report.

Almonte M and Velsquez-Jones L and Valverde S and Carleton B and Medeiros M

DOI: 10.1111/petr.12406 PubMed: 25418869

02 / 2015

Testosterone therapy and risk of myocardial infarction: a pharmacoepidemiologic study.

Etminan M and Skeldon SC and Goldenberg SL and Carleton B and Brophy JM

DOI: 10.1002/phar.1534 PubMed: 25582846

01 / 2015

Genetic determinants of cocaine-associated agranulocytosis.

Buxton JA and Omura J and Kuo M and Ross C and Tzemis D and Purssell R and Gardy J and Carleton B

DOI: 10.1186/s13104-015-1219-4 PubMed: 26070312

Use of pharmacogenomics in pediatric renal transplant recipients.

Medeiros M and Castaeda-Hernndez G and Ross CJ and Carleton BC

DOI: 10.3389/fgene.2015.00041 PubMed: 25741362

New Ways of Detecting ADRs in Neonates and Children.

Jimenez R and Smith A and Carleton B

PubMed: 26323415

Integrating Personalized Medicine in the Canadian Environment: Efforts Facilitating Oncology Clinical Research.

Syme R and Carleton B and Leyens L and Richer E

DOI: 10.1159/000441560 PubMed: 26565702

Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children.

Visscher H and Rassekh SR and Sandor GS and Caron HN and van Dalen EC and Kremer LC and van der Pal HJ and Rogers PC and Rieder MJ and Carleton BC and Hayden MR and Ross CJ and CPNDS consortium

DOI: 10.2217/pgs.15.61 PubMed: 26230641

Pharmacogenomic diversity in Singaporean populations and Europeans.

Brunham LR and Chan SL and Li R and Aminkeng F and Liu X and Saw WY and Ong RT and Pillai EN and Carleton BC and Toh D and Tan SH and Koo SH and Lee EJ and Chia KS and Ross CJ and Hayden MR and Sung C and Teo YY

DOI: 10.1038/tpj.2014.22 PubMed: 24861855

12 / 2014

Emergency department visits for children with acute asthma: discharge instructions, parental plans, and follow-through of care--a prospective study.

Camp PG and Norton SP and Goldman RD and Shajari S and Smith MA and Heathcote S and Carleton B

PubMed: 25358278

11 / 2014

Characteristics associated with drug-induced liver injury from interferon beta in multiple sclerosis patients.

Kowalec K and Kingwell E and Yoshida EM and Marrie RA and Kremenchutzky M and Campbell TL and Wadelius M and Carleton B and Tremlett H

DOI: 10.1517/14740338.2014.947958 PubMed: 25134421

10 / 2014

Risperidone use and risk for gynecomastia in men.

Etminan M and Heran B and Carleton B and Brophy JM

DOI: 10.1097/JCP.0000000000000182 PubMed: 25006814

10 / 2014

Genetic markers of cisplatin-induced hearing loss in children.

Carleton BC and Ross CJ and Pussegoda K and Bhavsar AP and Visscher H and Lee JW and Brooks B and Rassekh SR and Dub MP and Hayden MR

DOI: 10.1038/clpt.2014.92 PubMed: 25141953

09 / 2014

Hearing loss in Mexican children treated with cisplatin.

Casteln-Martnez OD and Jimnez-Mndez R and Rodrguez-Islas F and Fierro-Evans M and Vzquez-Gmez BE and Medina-Sansn A and Clark P and Carleton B and Ross C and Hildebrand C and Castaeda-Hernndez G and Rivas-Ruiz R

DOI: 10.1016/j.ijporl.2014.06.007 PubMed: 25037447

09 / 2014

Response to "evaluation of pharmacogenetic markers to predict the risk of Cisplatin-induced ototoxicity".

Carleton BC and Ross CJ and Bhavsar AP and Lee JW and Visscher H and Rassekh SR and Hayden MR

DOI: 10.1038/clpt.2014.90 PubMed: 24755913

08 / 2014

The emerging era of pharmacogenomics: current successes, future potential, and challenges.

Lee JW and Aminkeng F and Bhavsar AP and Shaw K and Carleton BC and Hayden MR and Ross CJ

DOI: 10.1111/cge.12392 PubMed: 24684508

07 / 2014

Development of a broad-based ADME panel for use in pharmacogenomic studies.

Brown AM and Renaud Y and Ross C and Hansen M and Mongrain I and Valois D and Carleton BC and Hayden MR and Dub MP and Tardif JC and Phillips MS

DOI: 10.2217/pgs.14.81 PubMed: 25141894

06 / 2014

Rising antipsychotic prescriptions for children and youth: cross-sectoral solutions for a multimodal problem.

Di Pietro N and Illes J and Canadian Working Group on Antipsychotic Medications and Children

DOI: 10.1503/cmaj.131604 PubMed: 24664655

06 / 2014

VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.

Shaw K and Amstutz U and Hildebrand C and Rassekh SR and Hosking M and Neville K and Leeder JS and Hayden MR and Ross CJ and Carleton BC

DOI: 10.1002/pbc.24932 PubMed: 24474498

06 / 2014

Codeine-related deaths: The role of pharmacogenetics and drug interactions.

Lam J and Woodall KL and Solbeck P and Ross CJ and Carleton BC and Hayden MR and Koren G and Madadi P

DOI: 10.1016/j.forsciint.2014.03.018 PubMed: 24747667

06 / 2014

Public perceptions of pharmacogenetics.

Zhang SC and Bruce C and Hayden M and Rieder MJ

DOI: 10.1542/peds.2013-1416 PubMed: 24777223

05 / 2014

Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions.

Amstutz U and Shear NH and Rieder MJ and Hwang S and Fung V and Nakamura H and Connolly MB and Ito S and Carleton BC and CPNDS clinical recommendation group

DOI: 10.1111/epi.12564 PubMed: 24597466

04 / 2014

Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent.

Aminkeng F and Ross CJ and Rassekh SR and Brunham LR and Sistonen J and Dube MP and Ibrahim M and Nyambo TB and Omar SA and Froment A and Bodo JM and Tishkoff S and Carleton BC and Hayden MR and Canadian Pharmacogenomics Network for Drug Safety Consortium

DOI: 10.1038/tpj.2013.13 PubMed: 23588107

04 / 2014

Role of TPMT and COMT genetic variation in cisplatin-induced ototoxicity.

Carleton BC and Ross CJ and Bhavsar AP and Amstutz U and Pussegoda K and Visscher H and Lee JW and Brooks B and Rassekh SR and Dub MP and Hayden MR

DOI: 10.1038/clpt.2013.219 PubMed: 24193170

03 / 2014

Exome sequencing pilot study in children with carbamazepine-induced serious skin reactions.

Amstutz U and Shyr C and Shear NH and Rieder MJ and Wasserman WW and Ross CJ and Carleton BC

DOI: 10.1186/2045-7022-4-S3-P119

Pharmacogenomics and adverse drug reactions in children.

Rieder MJ and Carleton B

DOI: 10.3389/fgene.2014.00078 PubMed: 24795743

Replication of TPMT and ABCC3 genetic variants highly associated with cisplatin-induced hearing loss in children.

Pussegoda K and Ross CJ and Visscher H and Yazdanpanah M and Brooks B and Rassekh SR and Zada YF and Dub MP and Carleton BC and Hayden MR and CPNDS Consortium

DOI: 10.1038/clpt.2013.80 PubMed: 23588304

08 / 2013

Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children.

Visscher H and Ross CJ and Rassekh SR and Sandor GS and Caron HN and van Dalen EC and Kremer LC and van der Pal HJ and Rogers PC and Rieder MJ and Carleton BC and Hayden MR and CPNDS Consortium

DOI: 10.1002/pbc.24505 PubMed: 23441093

08 / 2013

Putative association of ABCB1 2677G>T/A with oxycodone-induced central nervous system depression in breastfeeding mothers.

Lam J and Kelly L and Matok I and Ross CJ and Carleton BC and Hayden MR and Madadi P and Koren G

DOI: 10.1097/FTD.0b013e318288f158 PubMed: 23783165

08 / 2013

High use of health services in patients with suboptimal asthma drug regimens: a population-based assessment in British Columbia, Canada.

Zhang T and Smith MA and Camp PG and Carleton BC

DOI: 10.1002/pds.3444 PubMed: 23559540

07 / 2013

HLA-A 31:01 and HLA-B 15:02 as genetic markers for carbamazepine hypersensitivity in children.

Amstutz U and Ross CJ and Castro-Pastrana LI and Rieder MJ and Shear NH and Hayden MR and Carleton BC and CPNDS Consortium

DOI: 10.1038/clpt.2013.55 PubMed: 23588310

07 / 2013

The potential role of pharmacogenomics in the prevention of serious adverse drug reactions in multiple sclerosis.

Kowalec K and Carleton B and Tremlett H

DOI: 10.1016/j.msard.2012.11.003 PubMed: 25877724

07 / 2013

Cancer pharmacogenomics in children: research initiatives and progress to date.

Rassekh SR and Ross CJ and Carleton BC and Hayden MR

DOI: 10.1007/s40272-013-0021-9 PubMed: 23529868

04 / 2013

Prescription drug dispensing profiles for one million children: a population-based analysis.

Zhang T and Smith MA and Camp PG and Shajari S and MacLeod SM and Carleton BC

DOI: 10.1007/s00228-012-1343-1 PubMed: 22791273

03 / 2013

Suspected autoimmune hepatitis and primary biliary cirrhosis unmasked by interferon-beta in a multiple sclerosis patient.

Kowalec K and Yoshida EM and Traboulsee A and Carleton B and Tremlett H

DOI: 10.1016/j.msard.2012.07.004 PubMed: 25877455

01 / 2013

Pharmacogenomic investigation of adverse drug reactions(ADRs): the ADR prioritization tool, APT.

Shaw K and Amstutz U and Castro-Pastrana L and Loo TT and Ross CJ and Ito S and Reider MJ and Maher M and Macleod S and Koren G and Hayden MR and Carleton BC

PubMed: 23824325

Life-threatening adverse events following therapeutic opioid administration in adults: is pharmacogenetic analysis useful?

Madadi P and Sistonen J and Silverman G and Gladdy R and Ross CJ and Carleton BC and Carvalho JC and Hayden MR and Koren G

PubMed: 23748253

A clinical tool for reducing central nervous system depression among neonates exposed to codeine through breast milk.

Kelly LE and Chaudhry SA and Rieder MJ and 't Jong G and Moretti ME and Lausman A and Ross C and Berger H and Carleton B and Hayden MR and Madadi P and Koren G

DOI: 10.1371/journal.pone.0070073 PubMed: 23922910

Clinical practice guideline: CYP2D6 genotyping for safe and efficacious codeine therapy.

Madadi P and Amstutz U and Rieder M and Ito S and Fung V and Hwang S and Turgeon J and Michaud V and Koren G and Carleton BC and CPNDS Clinical Recommendations Group

PubMed: 24214521

The use of long-acting 2- agonists as monotherapy in children and adults.

Camp PG and Zhang T and Smith MA and Carleton BC

PubMed: 23392793

Physician variability in treating pain and irritability of unknown origin in children with severe neurological impairment.

Siden HB and Carleton BC and Oberlander TF

PubMed: 23885348

Apnea and oxygen desaturations in children treated with opioids after adenotonsillectomy for obstructive sleep apnea syndrome: a prospective pilot study.

Khetani JD and Madadi P and Sommer DD and Reddy D and Sistonen J and Ross CJ and Carleton BC and Hayden MR and Koren G

DOI: 10.1007/BF03262421 PubMed: 23013460

12 / 2012

Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: the devil is in the details.

Lam J and Matlow JN and Ross CJ and Hayden MR and Carleton BC and Madadi P

DOI: 10.1097/FTD.0b013e31825da19f PubMed: 22777151

08 / 2012

Economic impact of a genetic test for cisplatin-induced ototoxicity.

Dionne F and Mitton C and Rassekh R and Brooks B and Ross C and Hayden M and Carleton B

DOI: 10.1038/tpj.2011.15 PubMed: 21502965

06 / 2012

Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin.

Brunham LR and Lansberg PJ and Zhang L and Miao F and Carter C and Hovingh GK and Visscher H and Jukema JW and Stalenhoef AF and Ross CJ and Carleton BC and Kastelein JJ and Hayden MR

DOI: 10.1038/tpj.2010.92 PubMed: 21243006

06 / 2012

More codeine fatalities after tonsillectomy in North American children.

Kelly LE and Rieder M and van den Anker J and Malkin B and Ross C and Neely MN and Carleton B and Hayden MR and Madadi P and Koren G

DOI: 10.1542/peds.2011-2538 PubMed: 22492761

05 / 2012

Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children.

Visscher H and Ross CJ and Rassekh SR and Barhdadi A and Dub MP and Al-Saloos H and Sandor GS and Caron HN and van Dalen EC and Kremer LC and van der Pal HJ and Brown AM and Rogers PC and Phillips MS and Rieder MJ and Carleton BC and Hayden MR and Canadian Pharmacogenomics Network for Drug Safety Consortium

DOI: 10.1200/JCO.2010.34.3467 PubMed: 21900104

05 / 2012

Prediction of codeine toxicity in infants and their mothers using a novel combination of maternal genetic markers.

Sistonen J and Madadi P and Ross CJ and Yazdanpanah M and Lee JW and Landsmeer ML and Nauta M and Carleton BC and Koren G and Hayden MR

DOI: 10.1038/clpt.2011.280 PubMed: 22398969

04 / 2012

Suspected opioid overdose case resolved by CYP2D6 genotyping.

Shaw KD and Amstutz U and Jimenez-Mendez R and Ross CJ and Carleton BC

DOI: 10.1097/FTD.0b013e31824a1e21 PubMed: 22406651

04 / 2012

Fifty years of pediatric asthma in developed countries: how reliable are the basic data sources?

Chawla J and Seear M and Zhang T and Smith A and Carleton B

DOI: 10.1002/ppul.21537 PubMed: 21905263

03 / 2012

Central nervous system depression of neonates breastfed by mothers receiving oxycodone for postpartum analgesia.

Lam J and Kelly L and Ciszkowski C and Landsmeer ML and Nauta M and Carleton BC and Hayden MR and Madadi P and Koren G

DOI: 10.1016/j.jpeds.2011.06.050 PubMed: 21880331

01 / 2012

Beta-blocker use and COPD mortality: a systematic review and meta-analysis.

Etminan M and Jafari S and Carleton B and FitzGerald JM

DOI: 10.1186/1471-2466-12-48 PubMed: 22947076

Using pharmacogenetics to understand adverse drug reactions in children.

Shaw K and Amstutz U and Carleton BC

PubMed: 23115490

11 / 2011

Pharmacogenomics of cardiovascular drugs and adverse effects in pediatrics.

Visscher H and Amstutz U and Sistonen J and Ross CJ and Hayden MR and Carleton BC

DOI: 10.1097/FJC.0b013e3182163b82 PubMed: 21386709

09 / 2011

Diagnostic testing for vaccinomics: is the regulatory approval framework adequate? A comparison of Canada, the United States, and Europe.

Joly Y and Koutrikas G and Ramos-Paque E and Zawati M and Gardy J and Hayden MR and Carleton BC

DOI: 10.1089/omi.2010.0135 PubMed: 21728814

09 / 2011

CYP2D6 polymorphisms and codeine analgesia in postpartum pain management: a pilot study.

VanderVaart S and Berger H and Sistonen J and Madadi P and Matok I and Gijsen VM and de Wildt SN and Taddio A and Ross CJ and Carleton BC and Hayden MR and Koren G

DOI: 10.1097/FTD.0b013e3182272b10 PubMed: 21743374

08 / 2011

Technology enabled knowledge exchange: development of a conceptual framework.

Househ M and Kushniruk A and Cloutier-Fisher D and Carleton B

DOI: 10.1007/s10916-009-9408-0 PubMed: 20703520

08 / 2011

A literature review on distance knowledge exchange in healthcare groups: what can we learn from the ICT literature?

Househ MS and Kushniruk A and Carleton B and Cloutier-Fisher D

DOI: 10.1007/s10916-009-9401-7 PubMed: 20703525

08 / 2011

Pharmacogenetic testing: time for clinical practice guidelines.

Amstutz U and Carleton BC

DOI: 10.1038/clpt.2011.18 PubMed: 21508939

06 / 2011

Phenotype standardization for immune-mediated drug-induced skin injury.

Pirmohamed M and Friedmann PS and Molokhia M and Loke YK and Smith C and Phillips E and La Grenade L and Carleton B and Papaluca-Amati M and Demoly P and Shear NH

DOI: 10.1038/clpt.2011.79 PubMed: 21562486

06 / 2011

Sildenafil citrate therapy for severe early-onset intrauterine growth restriction.

von Dadelszen P and Dwinnell S and Magee LA and Carleton BC and Gruslin A and Lee B and Lim KI and Liston RM and Miller SP and Rurak D and Sherlock RL and Skoll MA and Wareing MM and Baker PN and Research into Advanced Fetal Diagnosis and Therapy (RAFT) Group

DOI: 10.1111/j.1471-0528.2010.02879.x PubMed: 21392225

04 / 2011

The use of conferencing technologies to support drug policy group knowledge exchange processes: an action case approach.

Househ MS and Kushniruk A and Maclure M and Carleton B and Cloutier-Fisher D

DOI: 10.1016/j.ijmedinf.2010.10.020 PubMed: 21167772

04 / 2011

Improving pediatric drug safety: need for more efficient clinical translation of pharmacovigilance knowledge.

Castro-Pastrana LI and Carleton BC

PubMed: 21467599

The communication of pharmacogenetic research results: participants weigh in on their informational needs in a pilot study.

Madadi P and Joly Y and Avard D and Chitayat DC and Smith MA and D Ross CJ and Carleton BC and Hayden MR and Koren G

PubMed: 21467605

Pharmacogenomics of serious adverse drug reactions in pediatric oncology.

Ross CJ and Visscher H and Rassekh SR and Castro-Pastrana LI and Shereck E and Carleton B and Hayden MR

PubMed: 21467604

A systematic review of treatment of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in children.

Del Pozzo-Magana BR and Lazo-Langner A and Carleton B and Castro-Pastrana LI and Rieder MJ

PubMed: 21467603

Cutaneous adverse drug reactions in children: an analysis of reports from the Canadian Pharmacogenomics Network for Drug Safety (CPNDS).

Castro-Pastrana LI and Ghannadan R and Rieder MJ and Dahlke E and Hayden M and Carleton B

PubMed: 21467602

Strengths and weaknesses of using conferencing technologies to support drug policy knowledge exchange.

Househ MS and Kushniruk AW and Macclure M and Carleton B and Cloutier-Fisher D

PubMed: 21335744

Regulatory approval for new pharmacogenomic tests: a comparative overview.

Joly Y and Koutrikas G and Tass AM and Issa A and Carleton B and Hayden M and Rieder MJ and Ramos-Paque E and Avard D

PubMed: 24505844

Demonstrating utility of pharmacogenetics in pediatric populations: methodological considerations.

Carleton B

DOI: 10.1038/clpt.2010.242 PubMed: 21081946

12 / 2010

Communicating pharmacogenetic research results to breastfeeding mothers taking codeine: a pilot study of perceptions and benefits.

Madadi P and Joly Y and Avard D and Chitayat DC and Smith MA and Ross CJ and Carleton BC and Hayden MR and Koren G

DOI: 10.1038/clpt.2010.125 PubMed: 20739920

12 / 2010

Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions.

Madadi P and Hildebrandt D and Gong IY and Schwarz UI and Ciszkowski C and Ross CJ and Sistonen J and Carleton BC and Hayden MR and Lauwers AE and Koren G

DOI: 10.1542/peds.2009-1907 PubMed: 20837591

10 / 2010

Pharmacogenomics and active surveillance for serious adverse drug reactions in children.

Loo TT and Ross CJ and Sistonen J and Visscher H and Madadi P and Koren G and Hayden MR and Carleton BC

DOI: 10.2217/pgs.10.111 PubMed: 20860467

09 / 2010

Palivizumab for the prevention of respiratory syncytial virus infection.

Rogovik AL and Carleton B and Solimano A and Goldman RD

PubMed: 20705882

08 / 2010

The Canadian Pharmacogenomics Network for Drug Safety: a model for safety pharmacology.

Ross CJ and Visscher H and Sistonen J and Brunham LR and Pussegoda K and Loo TT and Rieder MJ and Koren G and Carleton BC and Hayden MR and CPNDS Consortium

DOI: 10.1089/thy.2010.1642 PubMed: 20578893

07 / 2010

Gene-based warfaring dosing.

Carleton B

DOI: 10.1097/FTD.0b013e3181e1a665 PubMed: 20498559

06 / 2010

Predictive genotype.

Ito S and Carleton BC

DOI: 10.1503/cmaj.110-2061 PubMed: 20479057

05 / 2010

The comorbidity burden of the treated asthma patient population in British Columbia.

Prosser R and Carleton B and Smith A

PubMed: 20302685

03 / 2010

Cases: Cocaine adulterant linked to neutropenia.

Wiens MO and Son WK and Ross C and Hayden M and Carleton B

DOI: 10.1503/cmaj.090286 PubMed: 19969562

01 / 2010

Direct health care costs associated with asthma in British Columbia.

Sadatsafavi M and Lynd L and Marra C and Carleton B and Tan WC and Sullivan S and Fitzgerald JM

PubMed: 20422063

Application of principal component analysis to pharmacogenomic studies in Canada.

Visscher H and Ross CJ and Dub MP and Brown AM and Phillips MS and Carleton BC and Hayden MR

DOI: 10.1038/tpj.2009.36 PubMed: 19652663

12 / 2009

Use of oseltamivir in children.

Jamieson B and Jain R and Carleton B and Goldman RD

PubMed: 20008597

12 / 2009

The added burden of comorbidity in patients with asthma.

Zhang T and Carleton BC and Prosser RJ and Smith AM

DOI: 10.3109/02770900903350473 PubMed: 19995140

12 / 2009

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

Ross CJ and Katzov-Eckert H and Dub MP and Brooks B and Rassekh SR and Barhdadi A and Feroz-Zada Y and Visscher H and Brown AM and Rieder MJ and Rogers PC and Phillips MS and Carleton BC and Hayden MR and CPNDS Consortium

DOI: 10.1038/ng.478 PubMed: 19898482

12 / 2009

Thiazolidinediones and fractures in men and women.

Dormuth CR and Carney G and Carleton B and Bassett K and Wright JM

DOI: 10.1001/archinternmed.2009.214 PubMed: 19667303

08 / 2009

Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.

Carleton B and Poole R and Smith M and Leeder J and Ghannadan R and Ross C and Phillips M and Hayden M

DOI: 10.1002/pds.1772 PubMed: 19507171

08 / 2009

Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.

Madadi P and Ross CJ and Hayden MR and Carleton BC and Gaedigk A and Leeder JS and Koren G

DOI: 10.1038/clpt.2008.157 PubMed: 18719619

01 / 2009

A case study examining the impacts of conferencing technologies in distributed healthcare groups.

Househ M and Kushniruk A and Maclure M and Carleton B and Cloutier-Fisher D

PubMed: 20057239

Genotypic Approaches to Therapy in Children (GATC): using information technology to improve drug safety.

Wong E and Carleton BC and Wright DF and Smith MA and Verbeek L and Hildebrand CA and Stannard P and Vaillancourt R and Elliot-Miller P and Ross CJ and Hayden MR

PubMed: 19380938

Drug formulary decision-making in two regional health authorities in British Columbia, Canada.

Armstrong K and Mitton C and Carleton B and Shoveller J

DOI: 10.1016/j.healthpol.2008.04.006 PubMed: 18508151

12 / 2008

Statin use and the risk of Parkinson disease: a nested case control study.

Samii A and Carleton BC and Etminan M

DOI: 10.1016/j.jocn.2008.01.016 PubMed: 18823780

11 / 2008

Camouflaged sampling and contacting of people from administrative databases: reaching target patients without knowing who they are.

Maclure M and Warren L and Willison D and Cassels A and Carleton B

DOI: 10.1002/pds.1623 PubMed: 18615549

08 / 2008

Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: a retrospective cohort study.

Etminan M and Carleton BC and Samii A

DOI: 10.1016/j.jocn.2007.02.095 PubMed: 18343119

05 / 2008

Identifying persons with treated asthma using administrative data via latent class modelling.

Prosser RJ and Carleton BC and Smith MA

DOI: 10.1111/j.1475-6773.2007.00775.x PubMed: 18370976

04 / 2008

Medication errors: neonates, infants and children are the most vulnerable!

Poole RL and Carleton BC

DOI: 10.5863/1551-6776-13.2.65 PubMed: 23055866

04 / 2008

Trends in psychostimulant and antidepressant use by children in 2 Canadian provinces.

Mitchell B and Carleton B and Smith A and Prosser R and Brownell M and Kozyrskyj A

PubMed: 18441661

03 / 2008

Designed delays versus rigorous pragmatic trials: lower carat gold standards can produce relevant drug evaluations.

Maclure M and Carleton B and Schneeweiss S

DOI: 10.1097/MLR.0b013e318068932a PubMed: 17909382

10 / 2007

Genotypic approaches to therapy in children: a national active surveillance network (GATC) to study the pharmacogenomics of severe adverse drug reactions in children.

Ross CJ and Carleton B and Warn DG and Stenton SB and Rassekh SR and Hayden MR

DOI: 10.1196/annals.1423.020 PubMed: 17911433

09 / 2007

Effect of a clinical pathway on the hospitalisation rates of children with asthma: a prospective study.

Norton SP and Pusic MV and Taha F and Heathcote S and Carleton BC

DOI: 10.1136/adc.2006.097287 PubMed: 16905562

01 / 2007

Paediatric adverse drug reaction reporting: understanding and future directions.

Carleton BC and Smith MA and Gelin MN and Heathcote SC

PubMed: 17297195

Pharmacogenomics and its implications for autoimmune disease.

Ross CJ and Katzov H and Carleton B and Hayden MR

DOI: 10.1016/j.jaut.2007.02.008 PubMed: 17418528

Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with preeclampsia.

Magee LA and Miremadi S and Li J and Cheng C and Ensom MH and Carleton B and Ct AM and von Dadelszen P

DOI: 10.1016/j.ajog.2004.11.059 PubMed: 16021073

07 / 2005

Formulas containing live probiotic bacteria.

Falk J and Carleton B and Gerber P

PubMed: 15321825

09 / 2004

Macrolide therapy for Chlamydia pneumoniae in the secondary prevention of coronary artery disease: a meta-analysis of randomized controlled trials.

Etminan M and Carleton B and Delaney JA and Padwal R

DOI: 10.1592/phco.24.4.338.33181 PubMed: 15040646

03 / 2004

Clinical and economic consequences of a reimbursement restriction of nebulised respiratory therapy in adults: direct comparison of randomised and observational evaluations.

Schneeweiss S and Maclure M and Carleton B and Glynn RJ and Avorn J

DOI: 10.1136/bmj.38020.698194.F6 PubMed: 14982865

03 / 2004

Quantifying adverse drug events : are systematic reviews the answer?

Etminan M and Carleton B and Rochon PA

DOI: 10.2165/00002018-200427110-00001 PubMed: 15350149

Recognizing idiosyncratic adverse drug reactions in children: A practice imperative.

Carleton B and Primmett D

PubMed: 20084233

04 / 2001

From professional advocacy to patient advocacy: a gambit for pharmacists.

Carleton BC

PubMed: 11216105

Effects and ethics of sanctions on childhood immunization rates.

Maclure M and Carleton B and Schneeweiss S

DOI: 10.1001/jama.284.16.2056 PubMed: 11042749

10 / 2000

Evidence-based pharmacotherapy: review of basic concepts and applications in clinical practice.

Etminan M and Wright JM and Carleton BC

DOI: 10.1345/aph.17333 PubMed: 9825086

11 / 1998

Simple approach to dosage adjustment in patients with renal impairment.

McCormack JP and Cooper J and Carleton B

PubMed: 9359960

11 / 1997

A simpler approach to pharmacokinetic dosage adjustments.

McCormack JP and Carleton B

PubMed: 9399625

Overview of health-related quality-of-life measures for pediatric patients: application in the assessment of pharmacotherapeutic and pharmacoeconomic outcomes.

Marra CA and Levine M and McKerrow R and Carleton BC

PubMed: 8888083

Drug and poison information resources on the Internet, Part 2: Identification and evaluation.

Marra CA and Carleton BC and Lynd LD and Marra F and McDougal AR and Chow D and McKerrow R

PubMed: 8888076

Drug and poison information resources on the Internet, Part 1: An introduction.

Marra CA and Lynd LD and McKerrow R and Carleton BC

PubMed: 8840360

Comment: cost of rhDNase in cystic fibrosis.

Marra CA and Carleton BC and Basmadjian D and Levine M and McKerrow R

PubMed: 8845550

10 / 1995

Spurious rise in total carbon dioxide and chloride with negative anion gap after cystogram.

Abdel-Wareth LO and Lirenman DS and Halstead AC and McLellan D and Carleton BC

DOI: 10.1007/BF02254207 PubMed: 7632530

06 / 1995

Effects of three immunosuppressive drug protocols on cadaver renal transplantation costs after 4 years of therapy.

Canafax DM and Carleton BC and Matas AJ and Payne WD and Dunn DL and Sutherland DE and Najarian JS

PubMed: 8442239

02 / 1993

Reversed-phase high-performance liquid chromatographic approach to determine total lymphocyte concentrations of 6-thioguanine, methylmercaptopurine and methylthioguanine in humans.

Erdmann GR and Steury JC and Carleton BC and Stafford RJ and Bostrom BC and Canafax DM

PubMed: 1810943

11 / 1991

Method for evaluating drip-rate accuracy of intravenous flow-regulating devices.

Carleton BC and Cipolle RJ and Larson SD and Canafax DM

PubMed: 1746576

11 / 1991

Interaction between cyclosporine and fluconazole in renal allograft recipients.

Canafax DM and Graves NM and Hilligoss DM and Carleton BC and Gardner MJ and Matas AJ

PubMed: 2031258

05 / 1991

Increased cyclosporine levels as a result of simultaneous fluconazole and cyclosporine therapy in renal transplant recipients: a double-blind, randomized pharmacokinetic and safety study.

Canafax DM and Graves NM and Hilligoss DM and Carleton BC and Gardner MJ and Matas AJ

PubMed: 1989149

02 / 1991

Genomic and Outcomes Databank for Pharmacogenomic and Implementation Studies (GO PGx)

This Genome Canada project will reduce adverse drug reactions (ADRs) by developing genomic-based precision health strategies and technologies for the most common and severe ADRs in pediatric oncology and facilitate the implementation of pharmacogenomics into clinical practice. This will be realized through four parallel and complementary research activities that will result in genomic-based precision health deliverables for unique end-users:

1. Establish an ADR database of linked clinical and genomic data to discover and validate biomarkers of five severe ADRs associated with cancer therapy drugs in children.
2. Knowledge translation (KT) to facilitate the use of pharmacogenomics in pediatric oncology through the development of clinical practice guidelines and an educational program.
3. Implement ADR-predictive pharmacogenomics tests at 10 pediatric oncology centres across Canada.
4. Exploration of how pharmacogenomics testing in pediatric oncology impacts, and is impacted by patients, families, clinicians, and the Canadian healthcare system (GE3LS).

Integrating pediatric pharmacogenomic testing into the Canadian health care system

This project is focused on developing pharmacogenomic tests to predict the risk of experiencing an adverse drug reaction (ADR) in pediatric patients, and strives to bridge the gap between the rigorous science of pharmacogenomics and its integration into health care by providing a tool for the clinical uptake of rigorously derived pharmacogenomic information. To bridge this gap, we have identified actionable pharmacogenomic biomarkers for the most frequently prescribed medication classes and associated ADRs in children: antibiotics, analgesics, and mental health medications. These pharmacogenomic biomarkers all have a compelling rationale for inclusion and were based upon recommendations from FDA and/or Health Canada, Clinical Practice Guidelines, or discovery and replication of research findings in at least three independent populations. Using these robust genomic findings, we will develop three pharmacogenomic panels that possess high analytical validity as well as clinical utility. This product will therefore make the proven benefits of pharmacogenomics accessible to all pediatric patients and their clinicians and pharmacists in Canada. The availability of such tests would provide huge advantages to the thousands of children receiving these frequently prescribed medications every year and will significantly decrease the prevalence of severe and debilitating ADRs related to the most commonly prescribed medications in children.

Grants

Identifying Clinical Pharmacogenomic Predictors for Antibiotic-associated Severe Cutaneous Adverse Drug Reactions

An International Cohort Pilot Study – BC Children’s Hospital Research Institute Evidence to Innovation Theme Seed Grant Award (2020 – 2021)

Severe Cutaneous Adverse Drug Reactions (SCAR) 2019 International Meeting

From Science to Translation – CIHR Planning and Dissemination Grant (2018 – 2019)

Genomic and Outcomes Databank for Pharmacogenomic and Implementation Studies (GO PGx) – Genome Canada, Genome BC, CIHR Large Scale Applied Research Project Competition

Genomics and Precision Medicine (2018 – 2022)

DSEN SEARCH & PREVENT - Active Surveillance and Evaluation of Adverse Reactions in Canadian Healthcare AND Pharmacogenomics of Adverse Reactions EVEnts Nation-wide Team (Renewal) – CIHR Drug Safety and Effectiveness Network (2014 – 2021)

Domperidone to stimulate milk production during lactation and potential risk of serious ventricular arrhythmia and/or sudden cardiac death – CIHR Drug Safety and Effectiveness Network (2018 – 2020)

Integrating pediatric pharmacogenomic testing into the Canadian health care system – Genome Canada Applications Partnership Program (2017 – 2020)

Assessing the Impact of Pharmacogenomic Testing in Pediatric Oncology – Child and Family Research Institute – Evidence to Innovation Seed Grant Funding (2015 – 2016)

Active surveillance for evaluation of harm of direct acting oral anticoagulants (DOACs) in real world patients – CIHR Drug Safety and Effectiveness Network (2015 – 2017)

Clinical and pharmacogenomic predictors of inter-patient variation in direct acting oral anticoagulant (DOAC) plasma concentrations in real-world patients – CHIR Drug Safety and Effectiveness Network (2015 – 2017)

The Drug Safety and Effectiveness Cross-Disciplinary Training (DSECT) program – CIHR Drug Safety and Effectiveness Network Training Grant (2015 – 2020)

Optimizing Chronic Hepatitis C Treatment Using Pharmacogenomic Biomarkers – CIHR Drug Safety and Effectiveness Network (2014 – 2015)

5-HT3 Antagonists (Antiemetics) & Cardiac Safety, Using an Active Surveillance Approach – CIHR Drug Safety and Effectiveness Network (2013 – 2015)

Implementation of A Pharmacogenetic ADR Prevention Program in BC – Genome British Columbia & BC Provincial Health Services Authority (2012 – 2015)

Honours & Awards

2019 Fellow of the American College of Clinical Pharmacology (ACCP)

2018 Fellow of the International Society for Pharmacoepidemiology (ISPE)

2016 Canadian Society of Pharmacology and Therapeutics (CSPT) Distinguished Service and Education Award

“Recognizing Leadership Excellence” Award for service as Chair, Data Stewardship Committee at the BC Ministry of Health from 2009 – 2014

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