Tyler E. Dietterich and Rose Mary Xavier and Maya L. Lichtenstein and Matthew K. Harner and Lisa Bruno and Robert Stowe and Martilias Farrell and Rita A. Shaughnessy and Jonathan S. Berg and Patrick F. Sullivan and Richard C. Josiassen
DOI: 10.1101/2025.05.13.2532540005 / 2025
Progress in Neuro Psychopharmacology and Biological Psychiatry
Xavier, R.M. and Bian, W. and Alshammari, F. and Harner, M.K. and Dietterich, T.E. and Lichtenstein, M. and Stowe, R. and Farrell, M. and Szatkiewicz, J.P. and Shaughnessy, R.A. and Berg, J.S. and Sullivan, P.F. and Josiassen, R.C.
DOI: 10.1016/j.pnpbp.2025.111462European Neuropsychopharmacology
Gagan Singh and Indhu-Shree Rajan-Babu and Prescilla Carrion and William Rowell and Sanja Rogic and Mohadeseh Gharib Pour and Mike Guron and Julie MacIsaac and Agata Minor and Monica Hrynchak and Randall White and William Honer and Patrick Sullivan and Paul Pavlidis and Robert Stowe
DOI: 10.1016/j.euroneuro.2024.08.38410 / 2024
European Archives of Psychiatry and Clinical Neuroscience
Colijn, M.A. and Stowe, R.M.
DOI: 10.1007/s00406-024-01796-xProgress in Neuro-Psychopharmacology and Biological Psychiatry
Colijn, M.A. and Carrion, P. and Poirier-Morency, G. and Rogic, S. and Torres, I. and Menon, M. and Lisonek, M. and Cook, C. and DeGraaf, A. and Thammaiah, S.P. and Neelakant, H. and Willaeys, V. and Leonova, O. and White, R.F. and Yip, S. and Mungall, A.J. and MacLeod, P.M. and Gibson, W.T. and Sullivan, P.F. and Honer, W.G. and Pavlidis, P. and Stowe, R.M.
DOI: 10.1016/j.pnpbp.2023.110888CPT: Pharmacometrics and Systems Pharmacology
Mostafa, S. and Rafizadeh, R. and Polasek, T.M. and Bousman, C.A. and Rostami-Hodjegan, A. and Stowe, R. and Carrion, P. and Sheffield, L.J. and Kirkpatrick, C.M.J.
DOI: 10.1002/psp4.13093European Neuropsychopharmacology
Natasha Verzosa and Hilary Williams and Reza Rafizadeh and Ankita Narang and Prescilla Carrion and Ric Procyshyn and Randall White and Guillaume Poirier-Morency and Sanja Rogic and Andrew Mungall and Patrick Sullivan and William Honer and Paul Pavlidis and Robert Stowe and Chad Bousman
DOI: 10.1016/j.euroneuro.2022.07.28210 / 2022
Cognitive Neuropsychiatry
Zumrawi, D. and Glazier, B.L. and Leonova, O. and Menon, M. and Procyshyn, R. and White, R. and Stowe, R. and Honer, W.G. and Torres, I.J.
DOI: 10.1080/13546805.2022.2108389Schizophrenia Research
Colijn, M.A. and Torres, I.J. and Menon, M. and Howard, A. and Honer, W.G. and Stowe, R.M.
DOI: 10.1016/j.schres.2022.01.027Neurocase
Colijn, M.A. and Hrynchak, M. and Hrazdil, C.T. and Willaeys, V. and White, R.F. and Stowe, R.M.
DOI: 10.1080/13554794.2022.2132869European Neuropsychopharmacology
Robert Stowe and Guillaume Poirier-Morency and Sanja Rogic and Michelle Lisonek and Jessica Jun and Adrienne Elbert and Kennedy Borle and Courtney Cook and Olga Leonova and Prescilla Carrion and Chad Bousman and Monica Hrynchak and William Honer and Patrick Sullivan and Paul Pavlidis
DOI: 10.1016/j.euroneuro.2021.08.07310 / 2021
BC Schizophrenia Society
Aldridge, F., Cook, C., & Stowe, R. (2021, September 2021). In Schizophrenia: Nature vs. Nuture. F. Aldridge. https://www.bcss.org/lookagain/schizophrenia-nature-vs-nurture/
09 / 2021
medRxiv
Narang, A. and Lacaze, P. and Ronaldson, K.J. and McNeil, J.J. and Jayaram, M. and Thomas, N. and Sellmer, R. and Crockford, D. and Stowe, R. and Greenway, S.C. and Pantelis, C. and Bousman, C.A.
DOI: 10.1101/2021.07.26.21261157Pharmacopsychiatry
Bousman, C.A. and Bengesser, S.A. and Aitchison, K.J. and Amare, A.T. and Aschauer, H. and Baune, B.T. and Asl, B.B. and Bishop, J.R. and Burmeister, M. and Chaumette, B. and Chen, L.-S. and Cordner, Z.A. and Deckert, J. and Degenhardt, F. and Delisi, L.E. and Folkersen, L. and Kennedy, J.L. and Klein, T.E. and McClay, J.L. and McMahon, F.J. and Musil, R. and Saccone, N.L. and Sangkuhl, K. and Stowe, R.M. and Tan, E.-C. and Tiwari, A.K. and Zai, C.C. and Zai, G. and Zhang, J. and Gaedigk, A. and Mller, D.J.
DOI: 10.1055/a-1288-1061Cureus
Heba Yasin and Robert Stowe and Chi Kin Wong and Puthen Veettil Jithesh and Farah R Zahir
DOI: 10.7759/cureus.1157111 / 2020
Schizophrenia Research
Matthew K. Harner and Maya Lichtenstein and Martilias Farrell and Tyler E. Dietterich and Dawn M. Filmyer and Lisa M. Bruno and Tamara F. Biondi and James J. Crowley and Gabriel L{\'{a}}zaro-Mu{\~{n}}oz and Robert Stowe and Rita A. Shaughnessy and Jonathan S. Berg and Jin Szatkiewicz and Patrick F. Sullivan and Richard C. Josiassen}, title = {Treatment-resistant psychotic symptoms and early-onset dementia: A case report of the 3q29 deletion syndrome}, journal = {Schizophrenia Research
DOI: 10.1016/j.schres.2020.08.01209 / 2020
Molecular Genetics and Metabolism
Horvath, G.A. and Stowe, R.M. and Ferreira, C.R. and Blau, N.
DOI: 10.1016/j.ymgme.2020.02.007Clinical Neuropsychologist
Cassetta, B.D. and Menon, M. and Carrion, P.B. and Pearce, H. and DeGraaf, A. and Leonova, O. and White, R.F. and Stowe, R.M. and Honer, W.G. and Woodward, T.S. and Torres, I.J.
DOI: 10.1080/13854046.2019.1694072European Neuropsychopharmacology
Robert Stowe and Pedram Laghaei and Prescilla Carrion and Agata Minor and Christine Tyson and Ashley DeGraaf and William Honer and Patrick MacLeod and Harish Neelekant and Randall White and Monica Hrynchak
DOI: 10.1016/j.euroneuro.2018.08.184Journal of Human Genetics
Yasin, H. and Gibson, W.T. and Langlois, S. and Stowe, R.M. and Tsang, E.S. and Lee, L. and Poon, J. and Tran, G. and Tyson, C. and Wong, C.K. and Marra, M.A. and Friedman, J.M. and Zahir, F.R.
DOI: 10.1038/s10038-019-0561-0European Neuropsychopharmacology
Robert Stowe and Monica Hrynchak and Agata Minor and Christine Tyson and Prescilla Carrion and Ashley DeGraaf and Pedram Laghaei and Olga Leonova and Mahesh Menon and Ivan Torres and Veerle Willaeys and Randall White and Clara Westwell-Roper and Clare Beasley and William Honer
DOI: 10.1016/j.euroneuro.2018.08.337American Journal of Psychiatry
Farrell, M. and Lichtenstein, M. and Crowley, J.J. and Filmyer, D.M. and Lzaro-Muoz, G. and Shaughnessy, R.A. and Mackenzie, I.R. and Hirsch-Reinshagen, V. and Stowe, R. and Evans, J.P. and Berg, J.S. and Szatkiewicz, J. and Josiassen, R.C. and Sullivan, P.F.
DOI: 10.1176/appi.ajp.2017.17060638Experimental and Clinical Transplantation
Walker, G. and Hussaini, T. and Stowe, R. and Cresswell, S. and Yoshida, E.M.
DOI: 10.6002/ect.2016.0053Journal of the Neurological Sciences
Horvath, G.A. and Meisner, L. and Selby, K. and Stowe, R. and Carleton, B.
DOI: 10.1016/j.jns.2017.04.047Casebook of Neuropsychiatry
Casebook of Neuropsychiatry
Casebook of Neuropsychiatry
Casebook of Neuropsychiatry
Senses of Cinema [online journal]
Neurocase
Iaria, G. and Fox, C.J. and Scheel, M. and Stowe, R.M. and Barton, J.J.S.
DOI: 10.1080/13554790903329141BC Mental Health & Addiction Services Psychopharmacology Newsletter
Brain Research
Shimozaki, S. and Kingstone, A. and Olk, B. and Stowe, R. and Eckstein, M.
DOI: 10.1016/j.brainres.2006.01.033Masson
DOI: 10.1007/s10072-004-0359-412 / 2004
Neuropsichiatria: I disturbi del comportamento tra neurologia e psichiatria, 2nd ed
Neuropsichiatria: I disturbi del comportamento tra neurologia e psichiatria, 2nd ed.
Neuropsichiatria: I disturbi del comportamento tra neurologia e psichiatria, 2nd ed.
Neuropsichiatria: I disturbi del comportamento tra neurologia e psichiatria, 2nd ed.
Neuropsichiatria: I disturbi del comportamento tra neurologia e psichiatria, 2nd ed.
Canadian Psychiatric Association Bulletin
Stowe, R. M. (2002). Current concepts of the pathophysiology of catatonia. Canadian Psychiatric Association Bulletin, 34(1), 22-24.
02 / 2002
Encyclopedia of the Life Sciences
Neurology
DOI: 10.1212/wnl.53.6.129210 / 1999
Italian Journal of Neurological Sciences
Blundo, C. and Stowe, R.
Developmental medicine and child neurology
PubMed: 948950302 / 1998
Journal of Clinical and Experimental Neuropsychology
Schramke, C.J. and Stowe, R.M. and Ratcliff, G. and Goldstein, G. and Condray, R.
DOI: 10.1076/jcen.20.5.723.1117I disturbi del comportamento tra neurologia e psichiatria: basi neurobiologiche e sindromi cliniche
Neuropsychology
DOI: 10.1007/978-1-4899-1950-2_20Developmental Medicine and Child Neurology
Campo, J.V. and Stowe, R. and Slomka, G. and Byler, D. and Gracious, B.
DOI: 10.1111/j.1469-8749.1998.tb15374.xI disturbi del comportamento tra neurologia e psichiatria: basi neurobiologiche e sindromi cliniche
I disturbi del comportamento tra neurologia e psichiatria: basi neurobiologiche e sindromi cliniche
Masson
Cognitive Neuropsychology
DOI: 10.1080/02643299638183609 / 1996
Handbook of Aggressive and Destructive Behavior in Psychiatric Patients
DOI: 10.1007/978-1-4615-2403-8The Journal of Pediatrics
Putnam, P.E. and Orenstein, S.R. and Wessel, H.B. and Stowe, R.M.
DOI: 10.1016/S0022-3476(05)80357-9Brain
DOI: 10.1093/brain/113.5.1383Current Therapy in Neurological Disease
The MAGERS (Metabolic and Genetic Explorations in Refractory Schizophrenia) study (Robert Stowe, P.I; Precilla Carrion, Co-Project Lead) is a multi-layered clinical. "-omics", and genetic counselling research project that recruited 50 inpatient participants from the tertiary provincial BC Psychosis Unit at UBC Hospital suffering from highly treatment-resistant schizophrenia or schizoaffective disorder. Detailed clinical phenotyping included M.I.N.I psychiatric interviews and multidisciplinary consensus DSM-5 diagnosis, structured birth and childhood trauma histories, neurocognitive assessments, and neurological and dysmorphological examinations.
At entry, intensive biochemical screening for inborn errors of metabolism (IEMs) associated with psychosis was performed (Dr. Graham Sinclair), and clinical chromosomal microarrays were performed in the Royal Columbian Hospital Molecular Cytogenetics Laboratory. DNA and RNA extraction at RCH and in Dr. Michael Kobor’s laboratory was followed by long-read whole genome (PacBio HiFi) sequencing and peripheral blood RNA-Seq (Illumina HiSeq/NovaSeq). Exonic variant prioritization (Pavlidis lab, Indhu Shree Rajan Babu) has been completed, and noncoding variant and RNA analyses are underway. Pharmacogenetic (PGx) variants have been identified and correlated with medication profiles (Dr. Chad Bousman, University of Calgary). Clinically actionable results from CMAs, WGS, and PGx analyses are being returned to care providers, and to patients and families, through psychiatric genetic counselling (the impact of which is also being assessed as a research outcome).
Whole blood, peripheral blood mononuclear cells, serum, plasma, and urine on participants were collected and stored in Drs. Fabio Rossi and Michael Kobor’s labs. A cytokine and inflammatory marker panel has been performed on 25 cases (Dr. Clare Beasley). Proteomics and mass cytometry will be conducted if funding can be secured. Epigenetic analyses and polygenic risk (PRS) and pharmogenic enrichment (PES) scoring are underway in Dr. Murray Cairns’ lab at the University of Newcastle. Translational collaborations include rare variant-focused modelling in iPSCs (Dr. Mahmoud Pouladi; Dr. Michael Ziiller’s lab in Munster), in neurons and model organisms (in labs studying synaptic function), and in Drosophila models (Dr. Douglas Allan, DMCBH).
The main aim of the MAGERS study is to identify potent genomic and epigenomic risk variants indexing key mechanistic derangements driving psychosis in affected individuals, and indexing tractable treatment targets (such as ion channels, neurotransmitter systems, chromatin modifiers, and synaptic and dendritic function and plasticity, and major cellular and immunomodulatory pathways) that can be used to develop precision medicine for psychosis.
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