BCCHR Researchers Find a Researcher

Clare Beasley

Investigator, BC Children's Hospital

The major aim of my research is to identify changes in the brains of individuals with schizophrenia, bipolar disorder and major depressive disorder that may elucidate the etiology of these disorders and provide clues to novel treatments. Current projects focus on white matter pathology and inflammation. In addition, we study the effects of antipsychotic medications on the brain.

Academic Affiliations

Associate Professor, , Department of Psychiatry, Faculty of Medicine, University of British Columbia
Research Theme: Brain, Behaviour & Development
Research Group(s): Mental Health and Behaviour

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, v6h 3n1

(604) 875-2000 ext. 4723

cbeasley@mail.ubc.ca

Cytomegalovirus antibodies are associated with mood disorders, suicide, markers of neuroinflammation, and microglia activation in postmortem brain samples

Molecular Psychiatry

Zheng, H. and Webster, M.J. and Weickert, C.S. and Beasley, C.L. and Paulus, M.P. and Yolken, R.H. and Savitz, J.

DOI: 10.1038/s41380-023-02162-4

Severe symptoms predict salivary interleukin-6, interleukin-1, and tumor necrosis factor-a levels in children and youth with obsessive-compulsive disorder

Journal of Psychosomatic Research

Westwell-Roper, C. and Best, J.R. and Naqqash, Z. and Au, A. and Lin, B. and Lu, C. and Shao, L. and Beasley, C.L. and Stewart, S.E.

DOI: 10.1016/j.jpsychores.2022.110743

Diffusion kurtosis imaging of white matter in bipolar disorder

Vina M Goghari and Mavis Kusi and Mohammed K Shakeel and Clare Beasley and Szabolcs David and Alexander Leemans and Alberto De Luca and Louise Emsell

DOI: 10.1101/2021.02.01.21250951

02 / 2021

Diminished levels of the chemokine fractalkine in post-mortem prefrontal cortex in schizophrenia but not bipolar disorder

World Journal of Biological Psychiatry

Hill, S.L. and Shao, L. and Beasley, C.L.

DOI: 10.1080/15622975.2020.1755451

Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression

Schizophrenia Research

Beasley, C.L. and Honer, W.G. and Ramos-Miguel, A. and Vila-Rodriguez, F. and Barr, A.M.

DOI: 10.1016/j.schres.2017.05.033

Decreased medial entorhinal cortical thickness in olanzapine exposed female rats is not ameliorated by exercise

Pharmacology Biochemistry and Behavior

Woodward, M.L. and Ker, A.H. and Barr, A.M. and Beasley, C.L. and Hercher, C. and Boyda, H.N. and Procyshyn, R.M. and Honer, W.G. and Lang, D.J.

DOI: 10.1016/j.pbb.2019.172834

The SNAP25 Interactome in Ventromedial Caudate in Schizophrenia Includes the Mitochondrial Protein ARF1

Neuroscience

Ramos-Miguel, A. and Barakauskas, V. and Alamri, J. and Miyauchi, M. and Barr, A.M. and Beasley, C.L. and Rosoklija, G. and Mann, J.J. and Dwork, A.J. and Moradian, A. and Morin, G.B. and Honer, W.G.

DOI: 10.1016/j.neuroscience.2018.12.045

Reduced SNAP25 Protein Fragmentation Contributes to SNARE Complex Dysregulation in Schizophrenia Postmortem Brain

Neuroscience

Ramos-Miguel, A. and Gicas, K. and Alamri, J. and Beasley, C.L. and Dwork, A.J. and Mann, J.J. and Rosoklija, G. and Cai, F. and Song, W. and Barr, A.M. and Honer, W.G.

DOI: 10.1016/j.neuroscience.2018.12.015

Neuroadaptations to antipsychotic drugs: Insights from pre-clinical and human post-mortem studies

Neuroscience and Biobehavioral Reviews

Amato, D. and Beasley, C.L. and Hahn, M.K. and Vernon, A.C.

DOI: 10.1016/j.neubiorev.2016.10.004

Evidence for altered cell membrane lipid composition in postmortem prefrontal white matter in bipolar disorder and schizophrenia

Journal of Psychiatric Research

Ghosh, S. and Dyer, R.A. and Beasley, C.L.

DOI: 10.1016/j.jpsychires.2017.08.009

Deficits in axon-associated proteins in prefrontal white matter in bipolar disorder but not schizophrenia

Bipolar Disorders

Shao, L. and Golbaz, K. and Honer, W.G. and Beasley, C.L.

DOI: 10.1111/bdi.12395

Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia

Schizophrenia Research

Barakauskas, V.E. and Moradian, A. and Barr, A.M. and Beasley, C.L. and Rosoklija, G. and Mann, J.J. and Ilievski, B. and Stankov, A. and Dwork, A.J. and Falkai, P. and Morin, G.B. and Honer, W.G.

DOI: 10.1016/j.schres.2016.03.002

Exercise prevents downregulation of hippocampal presynaptic proteins following olanzapine-elicited metabolic dysregulation in rats: Distinct roles of inhibitory and excitatory terminals

Neuroscience

Ramos-Miguel, A. and Honer, W.G. and Boyda, H.N. and Sawada, K. and Beasley, C.L. and Procyshyn, R.M. and Barr, A.M.

DOI: 10.1016/j.neuroscience.2015.06.022

Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample

Molecular Neurodegeneration

Ramos-Miguel, A. and Hercher, C. and Beasley, C.L. and Barr, A.M. and Bayer, T.A. and Falkai, P. and Leurgans, S.E. and Schneider, J.A. and Bennett, D.A. and Honer, W.G.

DOI: 10.1186/s13024-015-0061-4

Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum

Neuroscience Letters

Andreazza, A.C. and Barakauskas, V.E. and Fazeli, S. and Feresten, A. and Shao, L. and Wei, V. and Wu, C.H. and Barr, A.M. and Beasley, C.L.

DOI: 10.1016/j.neulet.2015.02.028

Increased SNARE Protein-Protein Interactions in Orbitofrontal and Anterior Cingulate Cortices in Schizophrenia

Biological Psychiatry

Ramos-Miguel, A. and Beasley, C.L. and Dwork, A.J. and Mann, J.J. and Rosoklija, G. and Barr, A.M. and Honer, W.G.

DOI: 10.1016/j.biopsych.2014.12.012

Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder

Journal of Psychiatry and Neuroscience

Hercher, C. and Chopra, V. and Beasley, C.L.

DOI: 10.1503/jpn.130277

Proteomic and metabolomic evidence for glial alterations in schizophrenia

Proteomics and Metabolomics in Psychiatry

Beasley, C.L. and Barakauskas, V.E.

DOI: 10.1159/000358027

Increased hippocampal neurogenesis and p21 expression in depression: Dependent on antidepressants, sex, age, and antipsychotic exposure

Neuropsychopharmacology

Epp, J.R. and Beasley, C.L. and Galea, L.A.

DOI: 10.1038/npp.2013.132

Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness

Schizophrenia Research

Feresten, A.H. and Barakauskas, V. and Ypsilanti, A. and Barr, A.M. and Beasley, C.L.

DOI: 10.1016/j.schres.2013.07.024

Glucocorticoids increase protein carbonylation and mitochondrial dysfunction

Hormone and Metabolic Research

Tang, V.M. and Young, A.H. and Tan, H. and Beasley, C. and Wang, J.-F.

DOI: 10.1055/s-0033-1345119

Effects of chronic exercise and treatment with the antipsychotic drug olanzapine on hippocampal volume in adult female rats

Neuroscience

Barr, A.M. and Wu, C.H. and Wong, C. and Hercher, C. and Tpfer, E. and Boyda, H.N. and Procyshyn, R.M. and Honer, W.G. and Beasley, C.L.

DOI: 10.1016/j.neuroscience.2013.10.010

ApoE and cholesterol in schizophrenia and bipolar disorder: Comparison of grey and white matter and relation with APOE genotype

Journal of Psychiatry and Neuroscience

Vila-Rodriguez, F. and Honer, W.G. and Innis, S.M. and Wellington, C.L. and Beasley, C.L.

DOI: 10.1503/jpn.090116

Decreased mRNA expression of uncoupling protein 2, a mitochondrial proton transporter, in post-mortem prefrontal cortex from patients with bipolar disorder and schizophrenia

Neuroscience Letters

Gigante, A.D. and Andreazza, A.C. and Lafer, B. and Yatham, L.N. and Beasley, C.L. and Young, L.T.

DOI: 10.1016/j.neulet.2011.09.064

A Novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia

Neuropsychopharmacology

Barakauskas, V.E. and Beasley, C.L. and Barr, A.M. and Ypsilanti, A.R. and Li, H.-Y. and Thornton, A.E. and Wong, H. and Rosokilja, G. and Mann, J.J. and Mancevski, B. and Jakovski, Z. and Davceva, N. and Ilievski, B. and Dwork, A.J. and Falkai, P. and Honer, W.G.

DOI: 10.1038/npp.2009.228

Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Barakauskas, V.E. and Ypsilanti, A.R. and Barr, A.M. and Innis, S.M. and Honer, W.G. and Beasley, C.L.

DOI: 10.1016/j.pnpbp.2010.03.010

Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia

Schizophrenia Research

Beasley, C.L. and Dwork, A.J. and Rosoklija, G. and Mann, J.J. and Mancevski, B. and Jakovski, Z. and Davceva, N. and Tait, A.R. and Straus, S.K. and Honer, W.G.

DOI: 10.1016/j.schres.2009.01.017

Two-dimensional assessment of cytoarchitecture in the superior temporal white matter in schizophrenia, major depressive disorder and bipolar disorder

Schizophrenia Research

Beasley, C.L. and Honavar, M. and Everall, I.P. and Cotter, D.

DOI: 10.1016/j.schres.2009.09.028

Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder

Molecular Psychiatry

Pennington, K. and Beasley, C.L. and Dicker, P. and Fagan, A. and English, J. and Pariante, C.M. and Wait, R. and Dunn, M.J. and Cotter, D.R.

DOI: 10.1038/sj.mp.4002098

Calprotectin in microglia from frontal cortex is up-regulated in schizophrenia: Evidence for an inflammatory process?

European Journal of Neuroscience

Foster, R. and Kandanearatchi, A. and Beasley, C. and Williams, B. and Khan, N. and Fagerhol, M.K. and Everall, I.P.

DOI: 10.1111/j.1460-9568.2006.05219.x

Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: Evidence for disease-associated changes

Proteomics

Beasley, C.L. and Pennington, K. and Behan, A. and Wait, R. and Dunn, M.J. and Cotter, D.

DOI: 10.1002/pmic.200500069

Erratum (Retracted article): Expression of Oct-6, a POU III domain transcription factor, in schizophrenia (American Journal of Psychiatry (2002) 159 (1174-1182))

American Journal of Psychiatry

Beasley, C. and Meijer, D. and Kerwin, R. and Cotter, D. and Everall, I.A.N. and Price, J.

DOI: 10.1176/appi.ajp.163.8.1454

Evidence for altered neuronal organisation within the planum temporale in major psychiatric disorders

Schizophrenia Research

Beasley, C.L. and Chana, G. and Honavar, M. and Landau, S. and Everall, I.P. and Cotter, D.

DOI: 10.1016/j.schres.2004.08.011

Reductions in cholesterol and synaptic markers in association cortex in mood disorders

Bipolar Disorders

Beasley, C.L. and Honer, W.G. and von Bergmann, K. and Falkai, P. and Ltjohann, D. and Bayer, T.A.

DOI: 10.1111/j.1399-5618.2005.00239.x

Optimization of the first dimension for separation by two-dimensional gel electrophoresis of basic proteins from human brain tissue

Proteomics

Pennington, K. and McGregor, E. and Beasley, C.L. and Everall, I. and Cotter, D. and Dunn, M.J.

DOI: 10.1002/pmic.200300624

Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: Evidence for decreased neuronal somal size and increased neuronal density

Biological Psychiatry

Chana, G. and Landau, S. and Beasley, C. and Everall, I.P. and Cotter, D.

DOI: 10.1016/S0006-3223(03)00114-8

Density and distribution of white matter neurons in schizophrenia, bipolar disorder and major depressive disorder: No evidence for abnormalities of neuronal migration

Molecular Psychiatry

Beasley, C.L. and Cotter, D.R. and Everall, I.P.

DOI: 10.1038/sj.mp.4001038

The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia

Biological Psychiatry

Cotter, D. and Landau, S. and Beasley, C. and Stevenson, R. and Chana, G. and MacMillan, L. and Everall, I.

DOI: 10.1016/S0006-3223(01)01243-4

Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins

Biological Psychiatry

Beasley, C.L. and Zhang, Z.J. and Patten, I. and Reynolds, G.P.

DOI: 10.1016/S0006-3223(02)01360-4

Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder

Cerebral Cortex

Cotter, D. and Mackay, D. and Chana, G. and Beasley, C. and Landau, S. and Everall, I.P.

An investigation of the Wnt-signalling pathway in the prefrontal cortex in schizophrenia, bipolar disorder and major depressive disorder

Schizophrenia Research

Beasley, C. and Cotter, D. and Everall, I.

DOI: 10.1016/S0920-9964(01)00376-0

Expression of Oct-6, a POU III domain transcription factor, in schizophrenia

American Journal of Psychiatry

Ilia, M. and Beasley, C. and Meijer, D. and Kerwin, R. and Cotter, D. and Everall, I. and Price, J.

DOI: 10.1176/appi.ajp.159.7.1174

Understanding the neurotransmitter pathology of schizophrenia: Selective deficits of subtypes of cortical GABAergic neurons

Journal of Neural Transmission

Reynolds, G.P. and Beasley, C.L. and Zhang, Z.J.

DOI: 10.1007/s007020200072

GABAergic neuronal subtypes in the human frontal cortex - Development and deficits in schizophrenia

Journal of Chemical Neuroanatomy

Reynolds, G.P. and Beasley, C.L.

DOI: 10.1016/S0891-0618(01)00113-2

Glycogen synthase kinase-3 immunoreactivity is reduced in the prefrontal cortex in schizophrenia

Neuroscience Letters

Beasley, C. and Cotter, D. and Khan, N. and Pollard, C. and Sheppard, P. and Varndell, I. and Lovestone, S. and Anderton, B. and Everall, I.

DOI: 10.1016/S0304-3940(01)01688-3

Neurochemical correlates of cortical GABAergic deficits in schizophrenia: Selective losses of calcium binding protein immunoreactivity

Brain Research Bulletin

Reynolds, G.P. and Zhang, Z.J. and Beasley, C.L.

DOI: 10.1016/S0361-9230(01)00526-3

Neurochemical studies of AIDS and schizophrenia in post-mortem brain tissue

Journal of Neural Transmission

Reynolds, G.P. and Sardar, A.M. and Beasley, C.L. and Aparicio-Legarza, M.I.

Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics

Schizophrenia Research

Beasley, C.L. and Reynolds, G.P.

DOI: 10.1016/S0920-9964(96)00122-3

Brain development: the clinical perspective

Disorders of Brain and Mind

Clare Beasley and Brenda Williams and Ian Everall

DOI: 10.1017/cbo9780511550072.005

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Congratulations to the BC Children's Hospital Research Institute (BCCHR) and Women’s Health Research Institute (WHRI) investigators and their teams who were awarded funding through the Canadian Institutes of Health Research (CIHR) Fall 2021 Project Grant competition. Our research community received around $6 million in new research grants as principal investigators or co-investigators.
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Clare Beasley

Investigator, BC Children's Hospital

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Cytomegalovirus antibodies are associated with mood disorders, suicide, markers of neuroinflammation, and microglia activation in postmortem brain samples

Severe symptoms predict salivary interleukin-6, interleukin-1, and tumor necrosis factor-a levels in children and youth with obsessive-compulsive disorder

Diffusion kurtosis imaging of white matter in bipolar disorder

Diminished levels of the chemokine fractalkine in post-mortem prefrontal cortex in schizophrenia but not bipolar disorder

Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression

Decreased medial entorhinal cortical thickness in olanzapine exposed female rats is not ameliorated by exercise

The SNAP25 Interactome in Ventromedial Caudate in Schizophrenia Includes the Mitochondrial Protein ARF1

Reduced SNAP25 Protein Fragmentation Contributes to SNARE Complex Dysregulation in Schizophrenia Postmortem Brain

Neuroadaptations to antipsychotic drugs: Insights from pre-clinical and human post-mortem studies

Evidence for altered cell membrane lipid composition in postmortem prefrontal white matter in bipolar disorder and schizophrenia

Deficits in axon-associated proteins in prefrontal white matter in bipolar disorder but not schizophrenia

Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia

Exercise prevents downregulation of hippocampal presynaptic proteins following olanzapine-elicited metabolic dysregulation in rats: Distinct roles of inhibitory and excitatory terminals

Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample

Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum

Increased SNARE Protein-Protein Interactions in Orbitofrontal and Anterior Cingulate Cortices in Schizophrenia

Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder

Proteomic and metabolomic evidence for glial alterations in schizophrenia

Increased hippocampal neurogenesis and p21 expression in depression: Dependent on antidepressants, sex, age, and antipsychotic exposure

Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness

Glucocorticoids increase protein carbonylation and mitochondrial dysfunction

Effects of chronic exercise and treatment with the antipsychotic drug olanzapine on hippocampal volume in adult female rats

ApoE and cholesterol in schizophrenia and bipolar disorder: Comparison of grey and white matter and relation with APOE genotype

Decreased mRNA expression of uncoupling protein 2, a mitochondrial proton transporter, in post-mortem prefrontal cortex from patients with bipolar disorder and schizophrenia

A Novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia

Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels

Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia

Two-dimensional assessment of cytoarchitecture in the superior temporal white matter in schizophrenia, major depressive disorder and bipolar disorder

Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder

Calprotectin in microglia from frontal cortex is up-regulated in schizophrenia: Evidence for an inflammatory process?

Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: Evidence for disease-associated changes

Erratum (Retracted article): Expression of Oct-6, a POU III domain transcription factor, in schizophrenia (American Journal of Psychiatry (2002) 159 (1174-1182))

Evidence for altered neuronal organisation within the planum temporale in major psychiatric disorders

Reductions in cholesterol and synaptic markers in association cortex in mood disorders

Optimization of the first dimension for separation by two-dimensional gel electrophoresis of basic proteins from human brain tissue

Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: Evidence for decreased neuronal somal size and increased neuronal density

Density and distribution of white matter neurons in schizophrenia, bipolar disorder and major depressive disorder: No evidence for abnormalities of neuronal migration

The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia

Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins

Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder

An investigation of the Wnt-signalling pathway in the prefrontal cortex in schizophrenia, bipolar disorder and major depressive disorder

Expression of Oct-6, a POU III domain transcription factor, in schizophrenia

Understanding the neurotransmitter pathology of schizophrenia: Selective deficits of subtypes of cortical GABAergic neurons

GABAergic neuronal subtypes in the human frontal cortex - Development and deficits in schizophrenia

Glycogen synthase kinase-3 immunoreactivity is reduced in the prefrontal cortex in schizophrenia

Neurochemical correlates of cortical GABAergic deficits in schizophrenia: Selective losses of calcium binding protein immunoreactivity

Neurochemical studies of AIDS and schizophrenia in post-mortem brain tissue

Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics

Brain development: the clinical perspective

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Congratulations CIHR Fall 2021 Project Grant Recipients!

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