Overview

The major aim of my research is to identify changes in the brains of individuals with schizophrenia, bipolar disorder and major depressive disorder that may elucidate the etiology of these disorders and provide clues to novel treatments. Current projects focus on white matter pathology and inflammation. In addition, we study the effects of antipsychotic medications on the brain.

Publications

Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression
Schizophrenia Research
Clare L. Beasley and William G. Honer and Alfredo Ramos-Miguel and Fidel Vila-Rodriguez and Alasdair M. Barr
DOI: 10.1016/j.schres.2017.05.033
06/2017

Neuroadaptations to antipsychotic drugs: Insights from pre-clinical and human post-mortem studies
Neuroscience & Biobehavioral Reviews
Davide Amato and Clare L. Beasley and Margaret K. Hahn and Anthony C. Vernon
DOI: 10.1016/j.neubiorev.2016.10.004
05/2017

Evidence for altered cell membrane lipid composition in postmortem prefrontal white matter in bipolar disorder and schizophrenia
Journal of Psychiatric Research
Sanjoy Ghosh and Roger A. Dyer and Clare L. Beasley
DOI: 10.1016/j.jpsychires.2017.08.009
2017

Deficits in axon-associated proteins in prefrontal white matter in bipolar disorder but not schizophrenia
Bipolar Disord
Li Shao and Khashayar Golbaz and William G Honer and Clare L Beasley
DOI: 10.1111/bdi.12395
05/2016

Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia
Schizophrenia Research
Vilte E. Barakauskas and Annie Moradian and Alasdair M. Barr and Clare L. Beasley and Gorazd Rosoklija and J. John Mann and Boro Ilievski and Aleksandar Stankov and Andrew J. Dwork and Peter Falkai and Gregg B. Morin and William G. Honer
DOI: 10.1016/j.schres.2016.03.002
03/2016

Increased SNARE Protein-Protein Interactions in Orbitofrontal and Anterior Cingulate Cortices in Schizophrenia
Biological Psychiatry
Alfredo Ramos-Miguel and Clare L. Beasley and Andrew J. Dwork and J. John Mann and Gorazd Rosoklija and Alasdair M. Barr and William G. Honer
DOI: 10.1016/j.biopsych.2014.12.012
09/2015

Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum
Neuroscience Letters
Ana C. Andreazza and Vilte E. Barakauskas and Salar Fazeli and Abigail Feresten and Li Shao and Vivien Wei and Che Hsuan Wu and Alasdair M. Barr and Clare L. Beasley
DOI: 10.1016/j.neulet.2015.02.028
03/2015

Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample
Mol Neurodegeneration
Alfredo Ramos-Miguel and Christa Hercher and Clare L. Beasley and Alasdair M. Barr and Thomas A. Bayer and Peter Falkai and Sue E. Leurgans and Julie A. Schneider and David A. Bennett and William G. Honer
DOI: 10.1186/s13024-015-0061-4
2015

Exercise prevents downregulation of hippocampal presynaptic proteins following olanzapine-elicited metabolic dysregulation in rats: Distinct roles of inhibitory and excitatory terminals
Neuroscience
DOI: 10.1016/j.neuroscience.2015.06.022
2015

Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder
J Psychiatry Neurosci
DOI: 10.1503/jpn.130277
11/2014

Proteomic and Metabolomic Evidence for Glial Alterations in Schizophrenia
Proteomics and Metabolomics in Psychiatry
Clare L. Beasley and Vilte E. Barakauskas
DOI: 10.1159/000358027
2014

Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness
Schizophrenia Research
Abigail H. Feresten and Vilte Barakauskas and Athena Ypsilanti and Alasdair M. Barr and Clare L. Beasley
DOI: 10.1016/j.schres.2013.07.024
10/2013

Increased Hippocampal Neurogenesis and p21 Expression in Depression: Dependent on Antidepressants, Sex, Age, and Antipsychotic Exposure
Neuropsychopharmacology
Jonathan R Epp and Clare L Beasley and Liisa AM Galea
DOI: 10.1038/npp.2013.132
05/2013

Glucocorticoids increase protein carbonylation and mitochondrial dysfunction
Hormone and Metabolic Research
DOI: 10.1055/s-0033-1345119
2013

Effects of chronic exercise and treatment with the antipsychotic drug olanzapine on hippocampal volume in adult female rats
Neuroscience
DOI: 10.1016/j.neuroscience.2013.10.010
2013

Decreased mRNA expression of uncoupling protein 2, a mitochondrial proton transporter, in post-mortem prefrontal cortex from patients with bipolar disorder and schizophrenia
Neuroscience Letters
DOI: 10.1016/j.neulet.2011.09.064
2011

ApoE and cholesterol in schizophrenia and bipolar disorder: Comparison of grey and white matter and relation with APOE genotype
Journal of Psychiatry and Neuroscience
DOI: 10.1503/jpn.090116
2011

Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Vilte E. Barakauskas and Athena R. Ypsilanti and Alasdair M. Barr and Sheila M. Innis and William G. Honer and Clare L. Beasley
DOI: 10.1016/j.pnpbp.2010.03.010
05/2010

A Novel Mechanism and Treatment Target for Presynaptic Abnormalities in Specific Striatal Regions in Schizophrenia
Neuropsychopharmacology
Vilte E Barakauskas and Clare L Beasley and Alasdair M Barr and Athena R Ypsilanti and Hong-Ying Li and Allen E Thornton and Hubert Wong and Gorazd Rosokilja and J John Mann and Branislav Mancevski and Zlatko Jakovski and Natasha Davceva and Boro Ilievski and Andrew J Dwork and Peter Falkai and William G Honer
DOI: 10.1038/npp.2009.228
01/2010

Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia
Schizophrenia Research
Clare L. Beasley and Andrew J. Dwork and Gorazd Rosoklija and J. John Mann and Branislav Mancevski and Zlatko Jakovski and Natasa Davceva and Andrew R. Tait and Suzana K. Straus and William G. Honer
DOI: 10.1016/j.schres.2009.01.017
04/2009

Two-dimensional assessment of cytoarchitecture in the superior temporal white matter in schizophrenia, major depressive disorder and bipolar disorder
Schizophrenia Research
Clare L. Beasley and Mrinalini Honavar and Ian P. Everall and David Cotter
DOI: 10.1016/j.schres.2009.09.028
2009

Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder
Molecular Psychiatry
DOI: 10.1038/sj.mp.4002098
2008

Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: Evidence for disease-associated changes
Proteomics
Clare L. Beasley and Kyla Pennington and Aine Behan and Robin Wait and Michael J. Dunn and David Cotter
DOI: 10.1002/pmic.200500069
06/2006

Calprotectin in microglia from frontal cortex is up-regulated in schizophrenia: Evidence for an inflammatory process?
European Journal of Neuroscience
DOI: 10.1111/j.1460-9568.2006.05219.x
2006

Reductions in cholesterol and synaptic markers in association cortex in mood disorders
Bipolar Disorders
Clare L Beasley and William G Honer and Klaus Bergmann and Peter Falkai and Dieter Lutjohann and Thomas A Bayer
DOI: 10.1111/j.1399-5618.2005.00239.x
10/2005

Evidence for altered neuronal organisation within the planum temporale in major psychiatric disorders
Schizophrenia Research
Clare L. Beasley and Gursharan Chana and Mrinalini Honavar and Sabine Landau and Ian P. Everall and David Cotter
DOI: 10.1016/j.schres.2004.08.011
02/2005

Optimization of the first dimension for separation by two-dimensional gel electrophoresis of basic proteins from human brain tissue
Proteomics
Kyla Pennington and Emma McGregor and Clare L. Beasley and Ian Everall and David Cotter and Michael J. Dunn
DOI: 10.1002/pmic.200300624
01/2004

Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density
Biological Psychiatry
Gursharan Chana and Sabine Landau and Clare Beasley and Ian P Everall and David Cotter
DOI: 10.1016/s0006-3223(03)00114-8
06/2003

Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: Evidence for decreased neuronal somal size and increased neuronal density
Biological Psychiatry
DOI: 10.1016/S0006-3223(03)00114-8
2003

Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins
Biological Psychiatry
Clare L Beasley and Zhi J Zhang and Iain Patten and Gavin P Reynolds
DOI: 10.1016/s0006-3223(02)01360-4
10/2002

Expression of Oct-6, a POU III Domain Transcription Factor, in Schizophrenia
American Journal of Psychiatry
Maria Ilia and Clare Beasley and Dies Meijer and Robert Kerwin and David Cotter and Ian Everall and Jack Price
DOI: 10.1176/appi.ajp.159.7.1174
07/2002

The density and spatial distribution of gabaergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia
Biological Psychiatry
David Cotter and Sabine Landau and Clare Beasley and Robert Stevenson and Gursharon Chana and Laura MacMillan and Ian Everall
DOI: 10.1016/s0006-3223(01)01243-4
03/2002

Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder
Cerebral Cortex
2002

Understanding the neurotransmitter pathology of schizophrenia: Selective deficits of subtypes of cortical GABAergic neurons
Journal of Neural Transmission
DOI: 10.1007/s007020200072
2002

Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins
Biological Psychiatry
DOI: 10.1016/S0006-3223(02)01360-4
2002

Density and distribution of white matter neurons in schizophrenia, bipolar disorder and major depressive disorder: No evidence for abnormalities of neuronal migration
Molecular Psychiatry
DOI: 10.1038/sj.mp.4001038
2002

An investigation of the Wnt-signalling pathway in the prefrontal cortex in schizophrenia, bipolar disorder and major depressive disorder
Schizophrenia Research
DOI: 10.1016/S0920-9964(01)00376-0
2002

The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia
Biological Psychiatry
DOI: 10.1016/S0006-3223(01)01243-4
2002

Neurochemical correlates of cortical GABAergic deficits in schizophrenia: selective losses of calcium binding protein immunoreactivity
Brain Research Bulletin
Gavin P Reynolds and Zhi Jun Zhang and Clare L Beasley
DOI: 10.1016/s0361-9230(01)00526-3
07/2001

GABAergic neuronal subtypes in the human frontal cortex — development and deficits in schizophrenia
Journal of Chemical Neuroanatomy
Gavin P Reynolds and Clare L Beasley
DOI: 10.1016/s0891-0618(01)00113-2
07/2001

Glycogen synthase kinase-3ß immunoreactivity is reduced in the prefrontal cortex in schizophrenia
Neuroscience Letters
Clare Beasley and David Cotter and Nadeem Khan and Claire Pollard and Paul Sheppard and Ian Varndell and Simon Lovestone and Brian Anderton and Ian Everall
DOI: 10.1016/s0304-3940(01)01688-3
04/2001

Glycogen synthase kinase-3ß immunoreactivity is reduced in the prefrontal cortex in schizophrenia
Neuroscience Letters
DOI: 10.1016/S0304-3940(01)01688-3
2001

Neurochemical correlates of cortical GABAergic deficits in schizophrenia: Selective losses of calcium binding protein immunoreactivity
Brain Research Bulletin
DOI: 10.1016/S0361-9230(01)00526-3
2001

GABAergic neuronal subtypes in the human frontal cortex - Development and deficits in schizophrenia
Journal of Chemical Neuroanatomy
DOI: 10.1016/S0891-0618(01)00113-2
2001

Neurochemical studies of AIDS and schizophrenia in post-mortem brain tissue
Journal of Neural Transmission
1997

Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics
Schizophrenia Research
DOI: 10.1016/S0920-9964(96)00122-3
1997

Brain development: the clinical perspective
Disorders of Brain and Mind
Clare Beasley and Brenda Williams and Ian Everall
DOI: 10.1017/cbo9780511550072.005

Research
Research Group Members

Sarah Hill, Graduate Student
Catherine Hsu
Sangeetha Kasturi, Directed Studies Student, Summer Student
Li Shao, Research Asst/Tech 3