Overview

The major aim of my research is to identify changes in the brains of individuals with schizophrenia, bipolar disorder and major depressive disorder that may elucidate the etiology of these disorders and provide clues to novel treatments. Current projects focus on white matter pathology and inflammation. In addition, we study the effects of antipsychotic medications on the brain.

Publications

Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression
Schizophrenia Research
Clare L. Beasley, William G. Honer, Alfredo Ramos-Miguel, Fidel Vila-Rodriguez, Alasdair M. Barr
DOI: 10.1016/j.schres.2017.05.033
06/2017

Neuroadaptations to antipsychotic drugs: Insights from pre-clinical and human post-mortem studies
Neuroscience & Biobehavioral Reviews
Davide Amato, Clare L. Beasley, Margaret K. Hahn, Anthony C. Vernon
DOI: 10.1016/j.neubiorev.2016.10.004
05/2017

Evidence for altered cell membrane lipid composition in postmortem prefrontal white matter in bipolar disorder and schizophrenia
Journal of Psychiatric Research
Sanjoy Ghosh, Roger A. Dyer, Clare L. Beasley
DOI: 10.1016/j.jpsychires.2017.08.009
2017

Deficits in axon-associated proteins in prefrontal white matter in bipolar disorder but not schizophrenia
Bipolar Disord
Li Shao, Khashayar Golbaz, William G Honer, Clare L Beasley
DOI: 10.1111/bdi.12395
05/2016

Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia
Schizophrenia Research
Vilte E. Barakauskas, Annie Moradian, Alasdair M. Barr, Clare L. Beasley, Gorazd Rosoklija, J. John Mann, Boro Ilievski, Aleksandar Stankov, Andrew J. Dwork, Peter Falkai, Gregg B. Morin, William G. Honer
DOI: 10.1016/j.schres.2016.03.002
03/2016

Increased SNARE Protein-Protein Interactions in Orbitofrontal and Anterior Cingulate Cortices in Schizophrenia
Biological Psychiatry
Alfredo Ramos-Miguel, Clare L. Beasley, Andrew J. Dwork, J. John Mann, Gorazd Rosoklija, Alasdair M. Barr, William G. Honer
DOI: 10.1016/j.biopsych.2014.12.012
09/2015

Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum
Neuroscience Letters
Ana C. Andreazza, Vilte E. Barakauskas, Salar Fazeli, Abigail Feresten, Li Shao, Vivien Wei, Che Hsuan Wu, Alasdair M. Barr, Clare L. Beasley
DOI: 10.1016/j.neulet.2015.02.028
03/2015

Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample
Molecular Neurodegeneration
Ramos-Miguel, A. and Hercher, C. and Beasley, C.L. and Barr, A.M. and Bayer, T.A. and Falkai, P. and Leurgans, S.E. and Schneider, J.A. and Bennett, D.A. and Honer, W.G.
DOI: 10.1186/s13024-015-0061-4
2015

Exercise prevents downregulation of hippocampal presynaptic proteins following olanzapine-elicited metabolic dysregulation in rats: Distinct roles of inhibitory and excitatory terminals
Neuroscience
Ramos-Miguel, A. and Honer, W.G. and Boyda, H.N. and Sawada, K. and Beasley, C.L. and Procyshyn, R.M. and Barr, A.M.
DOI: 10.1016/j.neuroscience.2015.06.022
2015

Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder
J Psychiatry Neurosci
Christa Hercher and Vikramjit Chopra and Clare Beasley
DOI: 10.1503/jpn.130277
11/2014

Proteomic and metabolomic evidence for glial alterations in schizophrenia
Advances in Biological Psychiatry
Beasley, C.L. and Barakauskas, V.E.
DOI: 10.1159/000358027
2014

Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness
Schizophrenia Research
Abigail H. Feresten, Vilte Barakauskas, Athena Ypsilanti, Alasdair M. Barr, Clare L. Beasley
DOI: 10.1016/j.schres.2013.07.024
10/2013

Increased Hippocampal Neurogenesis and p21 Expression in Depression: Dependent on Antidepressants, Sex, Age, and Antipsychotic Exposure
Neuropsychopharmacology
Jonathan R Epp, Clare L Beasley, Liisa AM Galea
DOI: 10.1038/npp.2013.132
05/2013

Glucocorticoids increase protein carbonylation and mitochondrial dysfunction
Hormone and Metabolic Research
Tang, V.M. and Young, A.H. and Tan, H. and Beasley, C. and Wang, J.-F.
DOI: 10.1055/s-0033-1345119
2013

Effects of chronic exercise and treatment with the antipsychotic drug olanzapine on hippocampal volume in adult female rats
Neuroscience
Barr, A.M., Wu, C.H., Wong, C., Hercher, C., Töpfer, E., Boyda, H.N., Procyshyn, R.M., Honer, W.G., Beasley, C.L.
DOI: 10.1016/j.neuroscience.2013.10.010
2013

ApoE and cholesterol in schizophrenia and bipolar disorder: Comparison of grey and white matter and relation with APOE genotype
Journal of Psychiatry and Neuroscience
Vila-Rodriguez, F. and Honer, W.G. and Innis, S.M. and Wellington, C.L. and Beasley, C.L.
DOI: 10.1503/jpn.090116
2011

Decreased mRNA expression of uncoupling protein 2, a mitochondrial proton transporter, in post-mortem prefrontal cortex from patients with bipolar disorder and schizophrenia
Neuroscience Letters
Gigante, A.D. and Andreazza, A.C. and Lafer, B. and Yatham, L.N. and Beasley, C.L. and Young, L.T.
DOI: 10.1016/j.neulet.2011.09.064
2011

Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Vilte E. Barakauskas, Athena R. Ypsilanti, Alasdair M. Barr, Sheila M. Innis, William G. Honer, Clare L. Beasley
DOI: 10.1016/j.pnpbp.2010.03.010
05/2010

A Novel Mechanism and Treatment Target for Presynaptic Abnormalities in Specific Striatal Regions in Schizophrenia
Neuropsychopharmacology
Vilte E Barakauskas, Clare L Beasley, Alasdair M Barr, Athena R Ypsilanti, Hong-Ying Li, Allen E Thornton, Hubert Wong, Gorazd Rosokilja, J John Mann, Branislav Mancevski, Zlatko Jakovski, Natasha Davceva, Boro Ilievski, Andrew J Dwork, Peter Falkai, William G Honer
DOI: 10.1038/npp.2009.228
01/2010

Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia
Schizophrenia Research
Clare L. Beasley, Andrew J. Dwork, Gorazd Rosoklija, J. John Mann, Branislav Mancevski, Zlatko Jakovski, Natasa Davceva, Andrew R. Tait, Suzana K. Straus, William G. Honer
DOI: 10.1016/j.schres.2009.01.017
04/2009

Two-dimensional assessment of cytoarchitecture in the superior temporal white matter in schizophrenia, major depressive disorder and bipolar disorder
Schizophrenia Research
Clare L. Beasley, Mrinalini Honavar, Ian P. Everall, David Cotter
DOI: 10.1016/j.schres.2009.09.028
2009

Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder
Molecular Psychiatry
Pennington, K. and Beasley, C.L. and Dicker, P. and Fagan, A. and English, J. and Pariante, C.M. and Wait, R. and Dunn, M.J. and Cotter, D.R.
DOI: 10.1038/sj.mp.4002098
2008

Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: Evidence for disease-associated changes
Proteomics
Clare L. Beasley, Kyla Pennington, Aine Behan, Robin Wait, Michael J. Dunn, David Cotter
DOI: 10.1002/pmic.200500069
06/2006

Calprotectin in microglia from frontal cortex is up-regulated in schizophrenia: Evidence for an inflammatory process?
European Journal of Neuroscience
Foster, R. and Kandanearatchi, A. and Beasley, C. and Williams, B. and Khan, N. and Fagerhol, M.K. and Everall, I.P.
DOI: 10.1111/j.1460-9568.2006.05219.x
2006

Reductions in cholesterol and synaptic markers in association cortex in mood disorders
Bipolar Disorders
Clare L Beasley, William G Honer, Klaus Bergmann, Peter Falkai, Dieter Lutjohann, Thomas A Bayer
DOI: 10.1111/j.1399-5618.2005.00239.x
10/2005

Evidence for altered neuronal organisation within the planum temporale in major psychiatric disorders
Schizophrenia Research
Clare L. Beasley, Gursharan Chana, Mrinalini Honavar, Sabine Landau, Ian P. Everall, David Cotter
DOI: 10.1016/j.schres.2004.08.011
02/2005

Optimization of the first dimension for separation by two-dimensional gel electrophoresis of basic proteins from human brain tissue
Proteomics
Kyla Pennington, Emma McGregor, Clare L. Beasley, Ian Everall, David Cotter, Michael J. Dunn
DOI: 10.1002/pmic.200300624
01/2004

Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density
Biological Psychiatry
Gursharan Chana, Sabine Landau, Clare Beasley, Ian P Everall, David Cotter
DOI: 10.1016/s0006-3223(03)00114-8
06/2003

Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: Evidence for decreased neuronal somal size and increased neuronal density
Biological Psychiatry
Chana, G. and Landau, S. and Beasley, C. and Everall, I.P. and Cotter, D.
DOI: 10.1016/S0006-3223(03)00114-8
2003

Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins
Biological Psychiatry
Clare L Beasley, Zhi J Zhang, Iain Patten, Gavin P Reynolds
DOI: 10.1016/s0006-3223(02)01360-4
10/2002

Expression of Oct-6, a POU III Domain Transcription Factor, in Schizophrenia
American Journal of Psychiatry
Maria Ilia, Clare Beasley, Dies Meijer, Robert Kerwin, David Cotter, Ian Everall, Jack Price
DOI: 10.1176/appi.ajp.159.7.1174
07/2002

The density and spatial distribution of gabaergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia
Biological Psychiatry
David Cotter, Sabine Landau, Clare Beasley, Robert Stevenson, Gursharon Chana, Laura MacMillan, Ian Everall
DOI: 10.1016/s0006-3223(01)01243-4
03/2002

Density and distribution of white matter neurons in schizophrenia, bipolar disorder and major depressive disorder: No evidence for abnormalities of neuronal migration
Molecular Psychiatry
Beasley, C.L. and Cotter, D.R. and Everall, I.P.
DOI: 10.1038/sj.mp.4001038
2002

Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins
Biological Psychiatry
Beasley, C.L. and Zhang, Z.J. and Patten, I. and Reynolds, G.P.
DOI: 10.1016/S0006-3223(02)01360-4
2002

Understanding the neurotransmitter pathology of schizophrenia: Selective deficits of subtypes of cortical GABAergic neurons
Journal of Neural Transmission
Reynolds, G.P. and Beasley, C.L. and Zhang, Z.J.
DOI: 10.1007/s007020200072
2002

Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder
Cerebral Cortex
Cotter, D. and Mackay, D. and Chana, G. and Beasley, C. and Landau, S. and Everall, I.P.
2002

An investigation of the Wnt-signalling pathway in the prefrontal cortex in schizophrenia, bipolar disorder and major depressive disorder
Schizophrenia Research
Beasley, C. and Cotter, D. and Everall, I.
DOI: 10.1016/S0920-9964(01)00376-0
2002

The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia
Biological Psychiatry
Cotter, D. and Landau, S. and Beasley, C. and Stevenson, R. and Chana, G. and MacMillan, L. and Everall, I.
DOI: 10.1016/S0006-3223(01)01243-4
2002

Neurochemical correlates of cortical GABAergic deficits in schizophrenia: selective losses of calcium binding protein immunoreactivity
Brain Research Bulletin
Gavin P Reynolds, Zhi Jun Zhang, Clare L Beasley
DOI: 10.1016/s0361-9230(01)00526-3
07/2001

GABAergic neuronal subtypes in the human frontal cortex — development and deficits in schizophrenia
Journal of Chemical Neuroanatomy
Gavin P Reynolds, Clare L Beasley
DOI: 10.1016/s0891-0618(01)00113-2
07/2001

Glycogen synthase kinase-3ß immunoreactivity is reduced in the prefrontal cortex in schizophrenia
Neuroscience Letters
Clare Beasley, David Cotter, Nadeem Khan, Claire Pollard, Paul Sheppard, Ian Varndell, Simon Lovestone, Brian Anderton, Ian Everall
DOI: 10.1016/s0304-3940(01)01688-3
04/2001

Glycogen synthase kinase-3ß immunoreactivity is reduced in the prefrontal cortex in schizophrenia
Neuroscience Letters
Beasley, C. and Cotter, D. and Khan, N. and Pollard, C. and Sheppard, P. and Varndell, I. and Lovestone, S. and Anderton, B. and Everall, I.
DOI: 10.1016/S0304-3940(01)01688-3
2001

Neurochemical correlates of cortical GABAergic deficits in schizophrenia: Selective losses of calcium binding protein immunoreactivity
Brain Research Bulletin
Reynolds, G.P. and Zhang, Z.J. and Beasley, C.L.
DOI: 10.1016/S0361-9230(01)00526-3
2001

GABAergic neuronal subtypes in the human frontal cortex - Development and deficits in schizophrenia
Journal of Chemical Neuroanatomy
Reynolds, G.P. and Beasley, C.L.
DOI: 10.1016/S0891-0618(01)00113-2
2001

Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics
Schizophrenia Research
Beasley, C.L. and Reynolds, G.P.
DOI: 10.1016/S0920-9964(96)00122-3
1997

Neurochemical studies of AIDS and schizophrenia in post-mortem brain tissue
Journal of Neural Transmission
Reynolds, G.P. and Sardar, A.M. and Beasley, C.L. and Aparicio-Legarza, M.I.
1997

Brain development: the clinical perspective
Disorders of Brain and Mind
Clare Beasley, Brenda Williams, Ian Everall
DOI: 10.1017/cbo9780511550072.005

Research
Research Group Members

Li Shao
Quirin Strotzer
Sarah Hill, Graduate Student
Catherine Hsu