Overview

The goal of my research is to understand why certain patients respond positively to a medication, while others receive no benefit, or worse, develop debilitating or life-threatening adverse drug reactions(ADRs) to the same dose of medication. Individual patients respond differently to many medications because of small genetic differences that change the way a medication is metabolised.

By working collaboratively with clinicians and researchers from across Canada and around the world, we have recruited patients that have suffered specific serious ADRs, as well as control patients that have recived the same drugs without ADRs. We use high-throughput genomics and next-generation DNA sequencing technologies to identify the genetic factors of severe ADRs of key clinical importance.

The research involves many approaches from statistical, computational and molecular genetics, to molecular biology, and cell biology. The program’s mission is to translate these findings into new diagnostics that will improve the quality of lives of patients and families by preventing ADRs.

Publications

Further Investigation of the Role of ACYP2 and WFS1 Pharmacogenomic Variants in the Development of Cisplatin-Induced Ototoxicity in Testicular Cancer Patients.
Clinical cancer research : an official journal of the American Association for Cancer Research
Drögemöller BI, Brooks B, Critchley C, Monzon JG, Wright GEB, Liu G, Renouf DJ, Kollmannsberger CK, Bedard PL, Hayden MR, Gelmon KA, Carleton BC, Ross CJD
DOI: 10.1158/1078-0432.ccr-17-2810
PubMed: 29358504
04/2018

Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G > A and a large intragenic inversion in DPYD spanning intron 8 to intron 12.
Human mutation
van Kuilenburg ABP, Tarailo-Graovac M, Meijer J, Drogemoller B, Vockley J, Maurer D, Dobritzsch D, Ross CJ, Wasserman W, Meinsma R, Zoetekouw L, van Karnebeek CDM
DOI: 10.1002/humu.23538
PubMed: 29691939
04/2018

Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.
PM & R : the journal of injury, function, and rehabilitation
McLaughlin MJ, He Y, Brunstrom-Hernandez J, Thio LL, Carleton BC, Ross CJD, Gaedigk A, Lewandowski A, Dai H, Jusko WJ, Leeder JS
DOI: 10.1016/j.pmrj.2017.08.441
PubMed: 28867665
03/2018

The genotypic and phenotypic spectrum of MTO1 deficiency.
Molecular genetics and metabolism
O'Byrne JJ, Tarailo-Graovac M, Ghani A, Champion M, Deshpande C, Dursun A, Ozgul RK, Freisinger P, Garber I, Haack TB, Horvath R, Baric I, Husain RA, van Karnebeek CDM
DOI: 10.1016/j.ymgme.2017.11.003
PubMed: 29331171
01/2018

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.
Neurology
McCormack M, Gui H, Ingason A, Speed D, Wright GEB, Zhang EJ, Secolin R, Yasuda C, Kwok M, Wolking S, Becker F, Rau S, Avbersek A, Heggeli K, Leu C, Cavalleri GL
DOI: 10.1212/wnl.0000000000004853
PubMed: 29288229
01/2018

Improvement of Self-Injury With Dopamine and Serotonin Replacement Therapy in a Patient With a Hemizygous PAK3 Mutation: A New Therapeutic Strategy for Neuropsychiatric Features of an Intellectual Disability Syndrome.
Journal of child neurology
Horvath GA, Tarailo-Graovac M, Bartel T, Race S, Van Allen MI, Blydt-Hansen I, Ross CJ, Wasserman WW, Connolly MB, van Karnebeek CDM
DOI: 10.1177/0883073817740443
PubMed: 29246092
01/2018

Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer.
JAMA oncology
Drögemöller BI, Monzon JG, Bhavsar AP, Borrie AE, Brooks B, Wright GEB, Liu G, Renouf DJ, Kollmannsberger CK, Bedard PL, Aminkeng F, Amstutz U, Carleton BC
DOI: 10.1001/jamaoncol.2017.0502
PubMed: 28448657
11/2017

A de novo mosaic mutation in SPAST with two novel alternative alleles and chromosomal copy number variant in a boy with spastic paraplegia and autism spectrum disorder.
European journal of medical genetics
Matthews AM, Tarailo-Graovac M, Price EM, Blydt-Hansen I, Ghani A, Drögemöller BI, Robinson WP, Ross CJ, Wasserman WW, Siden H, van Karnebeek CD
DOI: 10.1016/j.ejmg.2017.07.015
PubMed: 28778789
10/2017

Exploring genetic influences underlying acute aerobic exercise effects on motor learning.
Scientific reports
Mang CS, McEwen LM, MacIsaac JL, Snow NJ, Campbell KL, Kobor MS, Ross CJD, Boyd LA
DOI: 10.1038/s41598-017-12422-3
PubMed: 28935933
09/2017

Application of pharmacogenomics to investigate adverse drug reactions to the disease-modifying treatments for multiple sclerosis: a case-control study protocol for dimethyl fumarate-induced lymphopenia.
BMJ open
Kowalec K, Kingwell E, Carruthers R, Marrie RA, Bernatsky S, Traboulsee A, Ross CJD, Carleton B, Tremlett H
DOI: 10.1136/bmjopen-2017-016276
PubMed: 28576902
06/2017

A pharmacogenetic signature of high response to Copaxone in late-phase clinical-trial cohorts of multiple sclerosis.
Genome medicine
Ross CJ, Towfic F, Shankar J, Laifenfeld D, Thoma M, Davis M, Weiner B, Kusko R, Zeskind B, Knappertz V, Grossman I, Hayden MR
DOI: 10.1186/s13073-017-0436-y
PubMed: 28569182
05/2017

A case of splenomegaly in CBL syndrome.
Coe RR, McKinnon ML, Tarailo-Graovac M, Ross CJ, Wasserman WW, Friedman JM, Rogers PC, van Karnebeek CDM
DOI: 10.1016/j.ejmg.2017.04.009
PubMed: 28414188
04/2017

Pharmacogenomic screening for anthracycline-induced cardiotoxicity in childhood cancer.
Aminkeng F, Ross CJ, Rassekh SR, Rieder MJ, Bhavsar AP, Sanatani S, Bernstein D, Hayden MR, Amstutz U, Carleton BC
DOI: 10.1111/bcp.13218
PubMed: 28317142
03/2017

A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
Armstrong L, Tarailo-Graovac M, Sinclair G, Seath KI, Wasserman WW, Ross CJ, van Karnebeek CD
DOI: 10.1002/ajmg.a.37621
PubMed: 28211985
03/2017

Identification of a large intronic transposal insertion in SLC17A5 causing sialic acid storage disease.
Tarailo-Graovac M, Drögemöller BI, Wasserman WW, Ross CJ, van den Ouweland AM, Darin N, Kollberg G, van Karnebeek CD, Blomqvist M
DOI: 10.1186/s13023-017-0584-6
PubMed: 28187749
02/2017

The targetable A1 Huntington disease haplotype has distinct Amerindian and European origins in Latin America.
Kay C, Tirado-Hurtado I, Cornejo-Olivas M, Collins JA, Wright G, Inca-Martinez M, Veliz-Otani D, Ketelaar ME, Slama RA, Ross CJ, Mazzetti P, Hayden MR
DOI: 10.1038/ejhg.2016.169
PubMed: 28000697
02/2017

Design and Methods of the Pan-Canadian Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Nephrotoxicity Study: A Prospective Observational Cohort Study.
McMahon KR, Rod Rassekh S, Schultz KR, Pinsk M, Blydt-Hansen T, Mammen C, Tsuyuki RT, Devarajan P, Cuvelier GD, Mitchell LG, Baruchel S, Palijan A, Carleton BC, Ross CJ, Zappitelli M, Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Group
DOI: 10.1177/2054358117690338
PubMed: 28270931
2017

Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines.
Bhavsar AP, Gunaretnam EP, Li Y, Hasbullah JS, Carleton BC, Ross CJ
DOI: 10.1371/journal.pone.0175711
PubMed: 28406961
2017

Mitochondrial Complex III Deficiency with Ketoacidosis and Hyperglycemia Mimicking Neonatal Diabetes.
Anastasio N, Tarailo-Graovac M, Al-Khalifah R, Legault L, Drogemoller B, Ross CJ, Wasserman WW, van Karnebeek C, Buhas D
DOI: 10.1007/8904_2016_557
PubMed: 27074787
2017

The global spectrum of protein-coding pharmacogenomic diversity.
Wright GE, Carleton B, Hayden MR, Ross CJ
DOI: 10.1038/tpj.2016.77
PubMed: 27779249
10/2016

Nuclear Receptor NR1H3 in Familial Multiple Sclerosis.
Wang Z, Sadovnick AD, Traboulsee AL, Ross JP, Bernales CQ, Encarnacion M, Yee IM, de Lemos M, Greenwood T, Lee JD, Wright G, Ross CJ, Zhang S, Song W, Vilariño-Güell C
DOI: 10.1016/j.neuron.2016.09.028
PubMed: 27764675
10/2016

Case-Control Studies Are Not Familial Studies.
Wang Z, Sadovnick AD, Traboulsee AL, Ross JP, Bernales CQ, Encarnacion M, Yee IM, de Lemos M, Greenwood T, Lee JD, Wright G, Ross CJ, Zhang S, Song W, Vilariño-Güell C
DOI: 10.1016/j.neuron.2016.09.053
PubMed: 27764669
10/2016

Editorial Note to:Nuclear Receptor NR1H3 in Familial Multiple Sclerosis.
Wang Z, Sadovnick AD, Traboulsee AL, Ross JP, Bernales CQ, Encarnacion M, Yee IM, de Lemos M, Greenwood T, Lee JD, Wright G, Ross CJ, Zhang S, Song W, Vilariño-Güell C
DOI: 10.1016/j.neuron.2016.10.008
PubMed: 27764666
10/2016

Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity.
Aminkeng F, Ross CJ, Rassekh SR, Hwang S, Rieder MJ, Bhavsar AP, Smith A, Sanatani S, Gelmon KA, Bernstein D, Hayden MR, Amstutz U, Carleton BC, CPNDS Clinical Practice Recommendations Group
DOI: 10.1111/bcp.13008
PubMed: 27197003
09/2016

A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene.
Wang CK, Aleksic A, Xu MS, Procyshyn RM, Ross CJ, Vila-Rodriguez F, Ramos-Miguel A, Yan R, Honer WG, Barr AM
DOI: 10.1089/gtmb.2015.0304
PubMed: 27228319
08/2016

Clinical Practice Recommendations for the Management and Prevention of Cisplatin-Induced Hearing Loss Using Pharmacogenetic Markers.
Lee JW, Pussegoda K, Rassekh SR, Monzon JG, Liu G, Hwang S, Bhavsar AP, Pritchard S, Ross CJ, Amstutz U, Carleton BC, CPNDS Clinical Recommendations Group
DOI: 10.1097/ftd.0000000000000298
PubMed: 26960170
08/2016

NANS-mediated synthesis of sialic acid is required for brain and skeletal development.
van Karnebeek CD, Bonafé L, Wen XY, Tarailo-Graovac M, Balzano S, Royer-Bertrand B, Ashikov A, Garavelli L, Mammi I, Turolla L, Breen C, Donnai D, Cormier V, Heron D, Nishimura G, Uchikawa S, Campos-Xavier B, Rossi A, Hennet T, Brand-Arzamendi K
DOI: 10.1038/ng.3578
PubMed: 27213289
07/2016

Exome Sequencing and the Management of Neurometabolic Disorders.
Tarailo-Graovac M, Shyr C, Ross CJ, Horvath GA, Salvarinova R, Ye XC, Zhang LH, Bhavsar AP, Lee JJ, Drögemöller BI, Abdelsayed M, Alfadhel M, Armstrong L, Baumgartner MR, Burda P, Connolly MB, Cameron J, Demos M, Dewan T, Dionne J
DOI: 10.1056/nejmoa1515792
PubMed: 27276562
06/2016

De novo dominant variants affecting the motor domain of KIF1A are a cause of PEHO syndrome.
Langlois S, Tarailo-Graovac M, Sayson B, Drögemöller B, Swenerton A, Ross CJ, Wasserman WW, van Karnebeek CD
DOI: 10.1038/ejhg.2015.217
PubMed: 26486474
06/2016

Nuclear Receptor NR1H3 in Familial Multiple Sclerosis.
Wang Z, Sadovnick AD, Traboulsee AL, Ross JP, Bernales CQ, Encarnacion M, Yee IM, de Lemos M, Greenwood T, Lee JD, Wright G, Ross CJ, Zhang S, Song W, Vilariño-Güell C
DOI: 10.1016/j.neuron.2016.04.039
PubMed: 27253448
06/2016

Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis.
Santra S, Cameron JM, Shyr C, Zhang L, Drögemöller B, Ross CJ, Wasserman WW, Wevers RA, Rodenburg RJ, Gupte G, Preece MA, van Karnebeek CD
DOI: 10.1016/j.ymgme.2016.03.001
PubMed: 26971250
05/2016

Forensic Investigation of Methadone Concentrations in Deceased Breastfed Infants.
Madadi P, Kelly LE, Ross CJ, Kepron C, Edwards JN, Koren G
DOI: 10.1111/1556-4029.12972
PubMed: 26513313
03/2016

Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro.
Cohen AS, Yap DB, Lewis ME, Chijiwa C, Ramos-Arroyo MA, Tkachenko N, Milano V, Fradin M, McKinnon ML, Townsend KN, Xu J, Van Allen MI, Ross CJ, Dobyns WB, Weaver DD, Gibson WT
DOI: 10.1002/humu.22946
PubMed: 26694085
03/2016

Secondary neurotransmitter deficiencies in epilepsy caused by voltage-gated sodium channelopathies: A potential treatment target?
Horvath GA, Demos M, Shyr C, Matthews A, Zhang L, Race S, Stockler-Ipsiroglu S, Van Allen MI, Mancarci O, Toker L, Pavlidis P, Ross CJ, Wasserman WW, Trump N, Heales S, Pope S, Cross JH, van Karnebeek CD
DOI: 10.1016/j.ymgme.2015.11.008
PubMed: 26647175
01/2016

Genetic diversity of variants involved in drug response and metabolism in Sri Lankan populations: implications for clinical implementation of pharmacogenomics.
Chan SL, Samaranayake N, Ross CJ, Toh MT, Carleton B, Hayden MR, Teo YY, Dissanayake VH, Brunham LR
DOI: 10.1097/fpc.0000000000000182
PubMed: 26444257
01/2016

Further Validation of the SIGMAR1 c.151+1G>T Mutation as Cause of Distal Hereditary Motor Neuropathy.
Child neurology open
Lee JJY, van Karnebeek CDM, Drögemoller B, Shyr C, Tarailo-Graovac M, Eydoux P, Ross CJ, Wasserman WW, Björnson B, Wu JK
DOI: 10.1177/2329048x16669912
PubMed: 28503617
2016

Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry.
Kay C, Collins JA, Skotte NH, Southwell AL, Warby SC, Caron NS, Doty CN, Nguyen B, Griguoli A, Ross CJ, Squitieri F, Hayden MR
DOI: 10.1038/mt.2015.128
PubMed: 26201449
11/2015

The pharmacogenetics of codeine pain relief in the postpartum period.
Baber M, Chaudhry S, Kelly L, Ross C, Carleton B, Berger H, Koren G
DOI: 10.1038/tpj.2015.3
PubMed: 25752520
10/2015

RMND1 deficiency associated with neonatal lactic acidosis, infantile onset renal failure, deafness, and multiorgan involvement.
Janer A, van Karnebeek CD, Sasarman F, Antonicka H, Al Ghamdi M, Shyr C, Dunbar M, Stockler-Ispiroglu S, Ross CJ, Vallance H, Dionne J, Wasserman WW, Shoubridge EA
DOI: 10.1038/ejhg.2014.293
PubMed: 25604853
10/2015

A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.
Aminkeng F, Bhavsar AP, Visscher H, Rassekh SR, Li Y, Lee JW, Brunham LR, Caron HN, van Dalen EC, Kremer LC, van der Pal HJ, Amstutz U, Rieder MJ, Bernstein D, Carleton BC, Hayden MR, Ross CJ, Canadian Pharmacogenomics Network for Drug Safety Consortium
DOI: 10.1038/ng.3374
PubMed: 26237429
09/2015

Development of a cost-efficient novel method for rapid, concurrent genotyping of five common single nucleotide polymorphisms of the brain derived neurotrophic factor (BDNF) gene by tetra-primer amplification refractory mutation system.
Wang CK, Xu MS, Ross CJ, Lo R, Procyshyn RM, Vila-Rodriguez F, White RF, Honer WG, Barr AM
DOI: 10.1002/mpr.1475
PubMed: 26118823
09/2015

Cisplatin Nephrotoxicity and Longitudinal Growth in Children With Solid Tumors: A Retrospective Cohort Study.
Jiménez-Triana CA, Castelán-Martínez OD, Rivas-Ruiz R, Jiménez-Méndez R, Medina A, Clark P, Rassekh R, Castañeda-Hernández G, Carleton B, Medeiros M, Canadian Pharmacogenomics Network for Drug Safety Consortium
DOI: 10.1097/md.0000000000001413
PubMed: 26313789
08/2015

Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy.
Shaw K, Amstutz U, Kim RB, Lesko LJ, Turgeon J, Michaud V, Hwang S, Ito S, Ross C, Carleton BC, CPNDS Clinical Recommendation Group
DOI: 10.1097/ftd.0000000000000192
PubMed: 26186657
08/2015

Genetic determinants of cocaine-associated agranulocytosis.
Buxton JA, Omura J, Kuo M, Ross C, Tzemis D, Purssell R, Gardy J, Carleton B
DOI: 10.1186/s13104-015-1219-4
PubMed: 26070312
06/2015

Association between regulatory advisories and codeine prescribing to postpartum women.
Smolina K, Weymann D, Morgan S, Ross C, Carleton B
DOI: 10.1001/jama.2015.3642
PubMed: 25965237
05/2015

Expansion of the QARS deficiency phenotype with report of a family with isolated supratentorial brain abnormalities.
Salvarinova R, Ye CX, Rossi A, Biancheri R, Roland EH, Pavlidis P, Ross CJ, Tarailo-Graovac M, Wasserman WW, van Karnebeek CD
DOI: 10.1007/s10048-014-0432-y
PubMed: 25432320
04/2015

Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms.
Sirrs S, van Karnebeek CD, Peng X, Shyr C, Tarailo-Graovac M, Mandal R, Testa D, Dubin D, Carbonetti G, Glynn SE, Sayson B, Robinson WP, Han B, Wishart D, Ross CJ, Wasserman WW, Hurwitz TA, Sinclair G, Kaczocha M
DOI: 10.1186/s13023-015-0248-3
PubMed: 25885783
03/2015

Use of pharmacogenomics in pediatric renal transplant recipients.
Medeiros M, Castañeda-Hernández G, Ross CJ, Carleton BC
DOI: 10.3389/fgene.2015.00041
PubMed: 25741362
2015

Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children.
Visscher H, Rassekh SR, Sandor GS, Caron HN, van Dalen EC, Kremer LC, van der Pal HJ, Rogers PC, Rieder MJ, Carleton BC, Hayden MR, Ross CJ, CPNDS consortium
DOI: 10.2217/pgs.15.61
PubMed: 26230641
2015

The genotypic and phenotypic spectrum of PIGA deficiency.
Tarailo-Graovac M, Sinclair G, Stockler-Ipsiroglu S, Van Allen M, Rozmus J, Shyr C, Biancheri R, Oh T, Sayson B, Lafek M, Ross CJ, Robinson WP, Wasserman WW, Rossi A, van Karnebeek CD
DOI: 10.1186/s13023-015-0243-8
PubMed: 25885527
2015

A single bout of high-intensity aerobic exercise facilitates response to paired associative stimulation and promotes sequence-specific implicit motor learning.
Mang CS, Snow NJ, Campbell KL, Ross CJ, Boyd LA
DOI: 10.1152/japplphysiol.00498.2014
PubMed: 25257866
12/2014

Pharmacogenomic diversity in Singaporean populations and Europeans.
Brunham LR, Chan SL, Li R, Aminkeng F, Liu X, Saw WY, Ong RT, Pillai EN, Carleton BC, Toh D, Tan SH, Koo SH, Lee EJ, Chia KS, Ross CJ, Hayden MR, Sung C, Teo YY
DOI: 10.1038/tpj.2014.22
PubMed: 24861855
12/2014

Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking.
Stockler S, Corvera S, Lambright D, Fogarty K, Nosova E, Leonard D, Steinfeld R, Ackerley C, Shyr C, Au N, Selby K, van Allen M, Vallance H, Wevers R, Watkins D, Rosenblatt D, Ross CJ, Conibear E, Wasserman W, van Karnebeek C
DOI: 10.1186/s13023-014-0141-5
PubMed: 25233840
09/2014

Genetic markers of cisplatin-induced hearing loss in children.
Carleton BC, Ross CJ, Pussegoda K, Bhavsar AP, Visscher H, Lee JW, Brooks B, Rassekh SR, Dubé MP, Hayden MR
DOI: 10.1038/clpt.2014.92
PubMed: 25141953
09/2014

Hearing loss in Mexican children treated with cisplatin.
Castelán-Martínez OD, Jiménez-Méndez R, Rodríguez-Islas F, Fierro-Evans M, Vázquez-Gómez BE, Medina-Sansón A, Clark P, Carleton B, Ross C, Hildebrand C, Castañeda-Hernández G, Rivas-Ruiz R
DOI: 10.1016/j.ijporl.2014.06.007
PubMed: 25037447
09/2014

AIMP1 deficiency presents as a cortical neurodegenerative disease with infantile onset.
Armstrong L, Biancheri R, Shyr C, Rossi A, Sinclair G, Ross CJ, Tarailo-Graovac M, Wasserman WW, van Karnebeek CD
DOI: 10.1007/s10048-014-0411-3
PubMed: 24958424
08/2014

Response to "evaluation of pharmacogenetic markers to predict the risk of Cisplatin-induced ototoxicity".
Carleton BC, Ross CJ, Bhavsar AP, Lee JW, Visscher H, Rassekh SR, Hayden MR
DOI: 10.1038/clpt.2014.90
PubMed: 24755913
08/2014

The emerging era of pharmacogenomics: current successes, future potential, and challenges.
Lee JW, Aminkeng F, Bhavsar AP, Shaw K, Carleton BC, Hayden MR, Ross CJ
DOI: 10.1111/cge.12392
PubMed: 24684508
07/2014

Codeine-related deaths: The role of pharmacogenetics and drug interactions.
Lam J, Woodall KL, Solbeck P, Ross CJ, Carleton BC, Hayden MR, Koren G, Madadi P
DOI: 10.1016/j.forsciint.2014.03.018
PubMed: 24747667
06/2014

Development of a broad-based ADME panel for use in pharmacogenomic studies.
Brown AM, Renaud Y, Ross C, Hansen M, Mongrain I, Valois D, Carleton BC, Hayden MR, Dubé MP, Tardif JC, Phillips MS
DOI: 10.2217/pgs.14.81
PubMed: 25141894
06/2014

VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.
Shaw K, Amstutz U, Hildebrand C, Rassekh SR, Hosking M, Neville K, Leeder JS, Hayden MR, Ross CJ, Carleton BC
DOI: 10.1002/pbc.24932
PubMed: 24474498
06/2014

DNAJC13 mutations in Parkinson disease.
Vilariño-Güell C, Rajput A, Milnerwood AJ, Shah B, Szu-Tu C, Trinh J, Yu I, Encarnacion M, Munsie LN, Tapia L, Gustavsson EK, Chou P, Tatarnikov I, Evans DM, Pishotta FT, Volta M, Beccano-Kelly D, Thompson C, Lin MK, Sherman HE
DOI: 10.1093/hmg/ddt570
PubMed: 24218364
04/2014

Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent.
Aminkeng F, Ross CJ, Rassekh SR, Brunham LR, Sistonen J, Dube MP, Ibrahim M, Nyambo TB, Omar SA, Froment A, Bodo JM, Tishkoff S, Carleton BC, Hayden MR, Canadian Pharmacogenomics Network for Drug Safety Consortium
DOI: 10.1038/tpj.2013.13
PubMed: 23588107
04/2014

Role of TPMT and COMT genetic variation in cisplatin-induced ototoxicity.
Carleton BC, Ross CJ, Bhavsar AP, Amstutz U, Pussegoda K, Visscher H, Lee JW, Brooks B, Rassekh SR, Dubé MP, Hayden MR
DOI: 10.1038/clpt.2013.219
PubMed: 24193170
03/2014

Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood.
van Karnebeek CD, Sly WS, Ross CJ, Salvarinova R, Yaplito-Lee J, Santra S, Shyr C, Horvath GA, Eydoux P, Lehman AM, Bernard V, Newlove T, Ukpeh H, Chakrapani A, Preece MA, Ball S, Pitt J, Vallance HD, Coulter-Mackie M, Nguyen H
DOI: 10.1016/j.ajhg.2014.01.006
PubMed: 24530203
03/2014

A novel recurrent mutation in ATP1A3 causes CAPOS syndrome.
Demos MK, van Karnebeek CD, Ross CJ, Adam S, Shen Y, Zhan SH, Shyr C, Horvath G, Suri M, Fryer A, Jones SJ, Friedman JM, FORGE Canada Consortium
DOI: 10.1186/1750-1172-9-15
PubMed: 24468074
01/2014

Exome sequencing pilot study in children with carbamazepine-induced serious skin reactions.
Amstutz U, Shyr C, Shear NH, Rieder MJ, Wasserman WW, Ross CJ, Carleton BC
DOI: 10.1186/2045-7022-4-s3-p119
2014

Promoting neuroplasticity for motor rehabilitation after stroke: considering the effects of aerobic exercise and genetic variation on brain-derived neurotrophic factor.
Mang CS, Campbell KL, Ross CJ, Boyd LA
DOI: 10.2522/ptj.20130053
PubMed: 23907078
12/2013

Instructor comfort level in high-fidelity simulation.
Harder BN, Ross CJ, Paul P
DOI: 10.1016/j.nedt.2012.09.003
PubMed: 23025906
10/2013

Putative association of ABCB1 2677G>T/A with oxycodone-induced central nervous system depression in breastfeeding mothers.
Lam J, Kelly L, Matok I, Ross CJ, Carleton BC, Hayden MR, Madadi P, Koren G
DOI: 10.1097/ftd.0b013e318288f158
PubMed: 23783165
08/2013

Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children.
Visscher H, Ross CJ, Rassekh SR, Sandor GS, Caron HN, van Dalen EC, Kremer LC, van der Pal HJ, Rogers PC, Rieder MJ, Carleton BC, Hayden MR, CPNDS Consortium
DOI: 10.1002/pbc.24505
PubMed: 23441093
08/2013

Replication of TPMT and ABCC3 genetic variants highly associated with cisplatin-induced hearing loss in children.
Pussegoda K, Ross CJ, Visscher H, Yazdanpanah M, Brooks B, Rassekh SR, Zada YF, Dubé MP, Carleton BC, Hayden MR, CPNDS Consortium
DOI: 10.1038/clpt.2013.80
PubMed: 23588304
08/2013

HLA-A 31:01 and HLA-B 15:02 as genetic markers for carbamazepine hypersensitivity in children.
Amstutz U, Ross CJ, Castro-Pastrana LI, Rieder MJ, Shear NH, Hayden MR, Carleton BC, CPNDS Consortium
DOI: 10.1038/clpt.2013.55
PubMed: 23588310
07/2013

From mutation identification to therapy: discovery and origins of the first approved gene therapy in the Western world.
Kastelein JJ, Ross CJ, Hayden MR
DOI: 10.1089/hum.2013.063
PubMed: 23578007
05/2013

Cancer pharmacogenomics in children: research initiatives and progress to date.
Rassekh SR, Ross CJ, Carleton BC, Hayden MR
DOI: 10.1007/s40272-013-0021-9
PubMed: 23529868
04/2013

A clinical tool for reducing central nervous system depression among neonates exposed to codeine through breast milk.
Kelly LE, Chaudhry SA, Rieder MJ, 't Jong G, Moretti ME, Lausman A, Ross C, Berger H, Carleton B, Hayden MR, Madadi P, Koren G
DOI: 10.1371/journal.pone.0070073
PubMed: 23922910
2013

Life-threatening adverse events following therapeutic opioid administration in adults: is pharmacogenetic analysis useful?
Madadi P, Sistonen J, Silverman G, Gladdy R, Ross CJ, Carleton BC, Carvalho JC, Hayden MR, Koren G
DOI: 10.1155/2013/518012
PubMed: 23748253
2013

Pharmacogenomic investigation of adverse drug reactions(ADRs): the ADR prioritization tool, APT.
Shaw K, Amstutz U, Castro-Pastrana L, Loo TT, Ross CJ, Ito S, Reider MJ, Maher M, Macleod S, Koren G, Hayden MR, Carleton BC
PubMed: 23824325
2013

The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity.
Bhavsar AP, Brown NF, Stoepel J, Wiermer M, Martin DD, Hsu KJ, Imami K, Ross CJ, Hayden MR, Foster LJ, Li X, Hieter P, Finlay BB
DOI: 10.1371/journal.ppat.1003518
PubMed: 23935490
2013

Clinical practice guideline: CYP2D6 genotyping for safe and efficacious codeine therapy.
Madadi P, Amstutz U, Rieder M, Ito S, Fung V, Hwang S, Turgeon J, Michaud V, Koren G, Carleton BC, CPNDS Clinical Recommendations Group
PubMed: 24214521
2013

Apnea and oxygen desaturations in children treated with opioids after adenotonsillectomy for obstructive sleep apnea syndrome: a prospective pilot study.
Khetani JD, Madadi P, Sommer DD, Reddy D, Sistonen J, Ross CJ, Carleton BC, Hayden MR, Koren G
DOI: 10.1007/bf03262421
PubMed: 23013460
12/2012

Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: the devil is in the details.
Lam J, Matlow JN, Ross CJ, Hayden MR, Carleton BC, Madadi P
DOI: 10.1097/ftd.0b013e31825da19f
PubMed: 22777151
08/2012

Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin.
Brunham LR, Lansberg PJ, Zhang L, Miao F, Carter C, Hovingh GK, Visscher H, Jukema JW, Stalenhoef AF, Ross CJ, Carleton BC, Kastelein JJ, Hayden MR
DOI: 10.1038/tpj.2010.92
PubMed: 21243006
06/2012

Economic impact of a genetic test for cisplatin-induced ototoxicity.
Dionne F, Mitton C, Rassekh R, Brooks B, Ross C, Hayden M, Carleton B
DOI: 10.1038/tpj.2011.15
PubMed: 21502965
06/2012

Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children.
Visscher H, Ross CJ, Rassekh SR, Barhdadi A, Dubé MP, Al-Saloos H, Sandor GS, Caron HN, van Dalen EC, Kremer LC, van der Pal HJ, Brown AM, Rogers PC, Phillips MS, Rieder MJ, Carleton BC, Hayden MR, Canadian Pharmacogenomics Network for Drug Safety Consortium
DOI: 10.1200/jco.2010.34.3467
PubMed: 21900104
05/2012

More codeine fatalities after tonsillectomy in North American children.
Kelly LE, Rieder M, van den Anker J, Malkin B, Ross C, Neely MN, Carleton B, Hayden MR, Madadi P, Koren G
DOI: 10.1542/peds.2011-2538
PubMed: 22492761
05/2012

Suspected opioid overdose case resolved by CYP2D6 genotyping.
Shaw KD, Amstutz U, Jimenez-Mendez R, Ross CJ, Carleton BC
DOI: 10.1097/ftd.0b013e31824a1e21
PubMed: 22406651
04/2012

Prediction of codeine toxicity in infants and their mothers using a novel combination of maternal genetic markers.
Sistonen J, Madadi P, Ross CJ, Yazdanpanah M, Lee JW, Landsmeer ML, Nauta M, Carleton BC, Koren G, Hayden MR
DOI: 10.1038/clpt.2011.280
PubMed: 22398969
04/2012

Pharmacogenomics of cardiovascular drugs and adverse effects in pediatrics.
Visscher H, Amstutz U, Sistonen J, Ross CJ, Hayden MR, Carleton BC
DOI: 10.1097/fjc.0b013e3182163b82
PubMed: 21386709
09/2011

CYP2D6 polymorphisms and codeine analgesia in postpartum pain management: a pilot study.
VanderVaart S, Berger H, Sistonen J, Madadi P, Matok I, Gijsen VM, de Wildt SN, Taddio A, Ross CJ, Carleton BC, Hayden MR, Koren G
DOI: 10.1097/ftd.0b013e3182272b10
PubMed: 21743374
08/2011

HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia.
Warby SC, Visscher H, Collins JA, Doty CN, Carter C, Butland SL, Hayden AR, Kanazawa I, Ross CJ, Hayden MR
DOI: 10.1038/ejhg.2010.229
PubMed: 21248742
05/2011

Pharmacogenomics of serious adverse drug reactions in pediatric oncology.
Ross CJ, Visscher H, Rassekh SR, Castro-Pastrana LI, Shereck E, Carleton B, Hayden MR
PubMed: 21467604
2011

Amelioration of hypertriglyceridemia with hypo-alpha-cholesterolemia in LPL deficient mice by hematopoietic cell-derived LPL.
Ding Y, Zhang L, Wang Y, Huang W, Tang Y, Bai L, Ross CJ, Hayden MR, Liu G
DOI: 10.1371/journal.pone.0025620
PubMed: 21980507
2011

Communicating pharmacogenetic research results to breastfeeding mothers taking codeine: a pilot study of perceptions and benefits.
Madadi P, Joly Y, Avard D, Chitayat DC, Smith MA, Ross CJ, Carleton BC, Hayden MR, Koren G
DOI: 10.1038/clpt.2010.125
PubMed: 20739920
12/2010

Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions.
Madadi P, Hildebrandt D, Gong IY, Schwarz UI, Ciszkowski C, Ross CJ, Sistonen J, Carleton BC, Hayden MR, Lauwers AE, Koren G
DOI: 10.1542/peds.2009-1907
PubMed: 20837591
10/2010

Pharmacogenomics and active surveillance for serious adverse drug reactions in children.
Loo TT, Ross CJ, Sistonen J, Visscher H, Madadi P, Koren G, Hayden MR, Carleton BC
DOI: 10.2217/pgs.10.111
PubMed: 20860467
09/2010

Ultrasound-guided sacroiliac joint injection in patients with established sacroiliitis: precise IA injection verified by MRI scanning does not predict clinical outcome.
Hartung W, Ross CJ, Straub R, Feuerbach S, Schölmerich J, Fleck M, Herold T
DOI: 10.1093/rheumatology/kep424
PubMed: 20019067
08/2010

The Canadian Pharmacogenomics Network for Drug Safety: a model for safety pharmacology.
Ross CJ, Visscher H, Sistonen J, Brunham LR, Pussegoda K, Loo TT, Rieder MJ, Koren G, Carleton BC, Hayden MR, CPNDS Consortium
DOI: 10.1089/thy.2010.1642
PubMed: 20578893
07/2010

The importance of XRCC2 in RAD51-related DNA damage repair.
Tambini CE, Spink KG, Ross CJ, Hill MA, Thacker J
DOI: 10.1016/j.dnarep.2010.01.016
PubMed: 20189471
05/2010

Perceptions about self-management among people with severe asthma.
Ross CJ, Williams BA, Low G, Vethanayagam D
DOI: 10.3109/02770901003611462
PubMed: 20394519
04/2010

Cases: Cocaine adulterant linked to neutropenia.
Wiens MO, Son WK, Ross C, Hayden M, Carleton B
DOI: 10.1503/cmaj.090286
PubMed: 19969562
01/2010

Characterization of microvascularization of liver tumor lesions with high resolution linear ultrasound and contrast enhanced ultrasound (CEUS) during surgery: First results.
Jung EM, Ross CJ, Rennert J, Scherer MN, Farkas S, von Breitenbuch P, Schnitzbauer AA, Piso P, Lamby P, Menzel C, Schreyer AG, Feuerbach S, Schlitt HJ, Loss M
DOI: 10.3233/ch-2010-1336
PubMed: 21135485
2010

Application of principal component analysis to pharmacogenomic studies in Canada.
Visscher H, Ross CJ, Dubé MP, Brown AM, Phillips MS, Carleton BC, Hayden MR
DOI: 10.1038/tpj.2009.36
PubMed: 19652663
12/2009

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
Ross CJ, Katzov-Eckert H, Dubé MP, Brooks B, Rassekh SR, Barhdadi A, Feroz-Zada Y, Visscher H, Brown AM, Rieder MJ, Rogers PC, Phillips MS, Carleton BC, Hayden MR, CPNDS Consortium
DOI: 10.1038/ng.478
PubMed: 19898482
12/2009

Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Carleton B, Poole R, Smith M, Leeder J, Ghannadan R, Ross C, Phillips M, Hayden M
DOI: 10.1002/pds.1772
PubMed: 19507171
08/2009

Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels.
Vaessen SF, Dallinga-Thie GM, Ross CJ, Splint LJ, Castellani LW, Rensen PC, Hayden MR, Schaap FG, Kuivenhoven JA
DOI: 10.1194/jlr.m800551-jlr200
PubMed: 19141870
05/2009

Presynaptic defects underlying impaired learning and memory function in lipoprotein lipase-deficient mice.
Xian X, Liu T, Yu J, Wang Y, Miao Y, Zhang J, Yu Y, Ross C, Karasinska JM, Hayden MR, Liu G, Chui D
DOI: 10.1523/jneurosci.0297-09.2009
PubMed: 19357293
04/2009

Enhanced susceptibility to pancreatitis in severe hypertriglyceridaemic lipoprotein lipase-deficient mice and agonist-like function of pancreatic lipase in pancreatic cells.
Wang Y, Sternfeld L, Yang F, Rodriguez JA, Ross C, Hayden MR, Carriere F, Liu G, Hofer W, Schulz I
DOI: 10.1136/gut.2007.146258
PubMed: 18936103
03/2009

Acute hypertriglyceridemic pancreatitis during pregnancy due to homozygous lipoprotein lipase gene mutation.
Bartha I, Dinya T, Seres I, Paragh G, Ross C, Hayden MR, Biró S, Vargha G
DOI: 10.1016/j.cca.2008.10.016
PubMed: 19000906
02/2009

The role of free fatty acids, pancreatic lipase and Ca+ signalling in injury of isolated acinar cells and pancreatitis model in lipoprotein lipase-deficient mice.
Yang F, Wang Y, Sternfeld L, Rodriguez JA, Ross C, Hayden MR, Carriere F, Liu G, Schulz I
DOI: 10.1111/j.1748-1716.2008.01933.x
PubMed: 18983441
01/2009

Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
Madadi P, Ross CJ, Hayden MR, Carleton BC, Gaedigk A, Leeder JS, Koren G
DOI: 10.1038/clpt.2008.157
PubMed: 18719619
01/2009

Genotypic Approaches to Therapy in Children (GATC): using information technology to improve drug safety.
Wong E, Carleton BC, Wright DF, Smith MA, Verbeek L, Hildebrand CA, Stannard P, Vaillancourt R, Elliot-Miller P, Ross CJ, Hayden MR
PubMed: 19380938
2009

Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase-deficient patients.
Stroes ES, Nierman MC, Meulenberg JJ, Franssen R, Twisk J, Henny CP, Maas MM, Zwinderman AH, Ross C, Aronica E, High KA, Levi MM, Hayden MR, Kastelein JJ, Kuivenhoven JA
DOI: 10.1161/atvbaha.108.175620
PubMed: 18802015
12/2008

Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet.
Zhang X, Qi R, Xian X, Yang F, Blackstein M, Deng X, Fan J, Ross C, Karasinska J, Hayden MR, Liu G
DOI: 10.1161/circresaha.107.156554
PubMed: 18032735
02/2008

Infant serotonin transporter (SLC6A4) promoter genotype is associated with adverse neonatal outcomes after prenatal exposure to serotonin reuptake inhibitor medications.
Oberlander TF, Bonaguro RJ, Misri S, Papsdorf M, Ross CJ, Simpson EM
DOI: 10.1038/sj.mp.4002007
PubMed: 17519929
01/2008

Genotypic approaches to therapy in children: a national active surveillance network (GATC) to study the pharmacogenomics of severe adverse drug reactions in children.
Ross CJ, Carleton B, Warn DG, Stenton SB, Rassekh SR, Hayden MR
DOI: 10.1196/annals.1423.020
PubMed: 17911433
09/2007

Screening and assessing adolescent asthmatics for anxiety disorders.
Ross CJ, Davis TM, Hogg DY
DOI: 10.1177/1054773806295235
PubMed: 17204805
02/2007

Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice.
Wang J, Xian X, Huang W, Chen L, Wu L, Zhu Y, Fan J, Ross C, Hayden MR, Liu G
DOI: 10.1161/01.atv.0000249683.80414.d9
PubMed: 17038632
01/2007

Pharmacogenomics and its implications for autoimmune disease.
Ross CJ, Katzov H, Carleton B, Hayden MR
DOI: 10.1016/j.jaut.2007.02.008
PubMed: 17418528
2007

Volumetric cartilage measurements of porcine knee at 1.5-T and 3.0-T MR imaging: evaluation of precision and accuracy.
Bauer JS, Krause SJ, Ross CJ, Krug R, Carballido-Gamio J, Ozhinsky E, Majumdar S, Link TM
DOI: 10.1148/radiol.2412051330
PubMed: 17057067
11/2006

Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma.
Burgess BL, McIsaac SA, Naus KE, Chan JY, Tansley GH, Yang J, Miao F, Ross CJ, van Eck M, Hayden MR, van Nostrand W, St George-Hyslop P, Westaway D, Wellington CL
DOI: 10.1016/j.nbd.2006.06.007
PubMed: 16899370
10/2006

Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation.
Rip J, Nierman MC, Ross CJ, Jukema JW, Hayden MR, Kastelein JJ, Stroes ES, Kuivenhoven JA
DOI: 10.1161/01.atv.0000219283.10832.43
PubMed: 16574898
06/2006

Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation.
Ross CJ, Twisk J, Bakker AC, Miao F, Verbart D, Rip J, Godbey T, Dijkhuizen P, Hermens WT, Kastelein JJ, Kuivenhoven JA, Meulenberg JM, Hayden MR
DOI: 10.1089/hum.2006.17.487
PubMed: 16716106
05/2006

Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia.
Zhao T, Guo J, Li H, Huang W, Xian X, Ross CJ, Hayden MR, Wen Z, Liu G
DOI: 10.1016/j.bbrc.2006.01.067
PubMed: 16460682
03/2006

Gene therapy for lipoprotein lipase deficiency: working toward clinical application.
Rip J, Nierman MC, Sierts JA, Petersen W, Van den Oever K, Van Raalte D, Ross CJ, Hayden MR, Bakker AC, Dijkhuizen P, Hermens WT, Twisk J, Stroes E, Kastelein JJ, Kuivenhoven JA, Meulenberg JM
DOI: 10.1089/hum.2005.16.1276
PubMed: 16259561
11/2005

Complete rescue of lipoprotein lipase-deficient mice by somatic gene transfer of the naturally occurring LPLS447X beneficial mutation.
Ross CJ, Liu G, Kuivenhoven JA, Twisk J, Rip J, van Dop W, Excoffon KJ, Lewis SM, Kastelein JJ, Hayden MR
DOI: 10.1161/01.atv.0000176971.27302.b0
PubMed: 16002740
10/2005

Cognitive-behavioral treatment combined with asthma education for adults with asthma and coexisting panic disorder.
Ross CJ, Davis TM, MacDonald GF
DOI: 10.1177/1054773804273863
PubMed: 15793272
05/2005

Long-term correction of murine lipoprotein lipase deficiency with AAV1-mediated gene transfer of the naturally occurring LPL(S447X) beneficial mutation.
Ross CJ, Twisk J, Meulenberg JM, Liu G, van den Oever K, Moraal E, Hermens WT, Rip J, Kastelein JJ, Kuivenhoven JA, Hayden MR
DOI: 10.1089/hum.2004.15.906
PubMed: 15353045
09/2004

Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1.
Wellington CL, Brunham LR, Zhou S, Singaraja RR, Visscher H, Gelfer A, Ross C, James E, Liu G, Huber MT, Yang YZ, Parks RJ, Groen A, Fruchart-Najib J, Hayden MR
DOI: 10.1194/jlr.m300110-jlr200
PubMed: 12730295
08/2003

A case study of comorbidities: vocal cord dysfunction, asthma, and panic disorder.
Heffern WA, Davis TM, Ross CJ
DOI: 10.1177/10573802011003007
PubMed: 12180643
08/2002

Screening and assessing adult asthmatics for anxiety disorders.
Davis TM, Ross CJ, MacDonald GF
DOI: 10.1177/105477380201100206
PubMed: 11991171
05/2002

Treatment of hemophilia B in mice with nonautologous somatic gene therapeutics.
Van Raamsdonk JM, Ross CJ, Potter MA, Kurachi S, Kurachi K, Stafford DW, Chang PL
DOI: 10.1067/mlc.2002.120649
PubMed: 11873243
01/2002

Development of small alginate microcapsules for recombinant gene product delivery to the rodent brain.
Ross CJ, Chang PL
DOI: 10.1163/156856202320401988
PubMed: 12463513
2002

Somatic gene therapy for a neurodegenerative disease using microencapsulated recombinant cells.
Ross CJ, Ralph M, Chang PL
DOI: 10.1006/exnr.2000.7531
PubMed: 11085893
12/2000

Treatment of a lysosomal storage disease, mucopolysaccharidosis VII, with microencapsulated recombinant cells.
Ross CJ, Bastedo L, Maier SA, Sands MS, Chang PL
DOI: 10.1089/104303400750001426
PubMed: 11044913
10/2000

Delivery of recombinant gene products to the central nervous system with nonautologous cells in alginate microcapsules.
Ross CJ, Ralph M, Chang PL
DOI: 10.1089/10430349950019183
PubMed: 10022530
01/1999

Encapsulation of various recombinant mammalian cell types in different alginate microcapsules.
Peirone M, Ross CJ, Hortelano G, Brash JL, Chang PL
DOI: 10.1002/(sici)1097-4636(19981215)42:43.0.co;2-x
PubMed: 9827683
12/1998

A sequence-ready physical map of a region of 12q24.1.
Renault B, Hovnanian A, Bryce S, Chang JJ, Lau S, Sakuntabhai A, Monk S, Carter S, Ross CJ, Pang J, Twells R, Chamberlain S, Monaco AP, Strachan T, Kucherlapati R
DOI: 10.1006/geno.1997.4888
PubMed: 9344649
10/1997

Informational coping styles: a validity study.
Ross CJ, Maguire TO
PubMed: 8935771
1995

Comparisons of pulmonary artery pressure measurements in supine and 30 degree lateral positions.
Ross CJ, Jones R
PubMed: 8573278
1995

Hawaii Asian-American response to the Staying Healthy After Fifty program.
Roberts E, Takenaka JI, Ross CJ, Chong EH, Tulang JI, Napps SE
PubMed: 2621109
1989

Treatment issues in child abuse.
Ross CJ, Zigler E
PubMed: 6400728
05/1983

Of children and liberty: an historian's view.
Ross CJ
PubMed: 7114175
07/1982

Project head start.
Valentine J, Ross CJ, Zigler E
PubMed: 7389433
1980

Age and alcoholism.
Warder J, Ross CJ
PubMed: 5283827
06/1971

Blood culture in the diagnosis of leptospirosis in North Queensland.
ROSS CJ
PubMed: 13264862
08/1955

The investigation of fevers in North Queensland by mouse inoculation, with particular reference to scrub typhus.
CARLEY JG, DOHERTY RL, DERRICK EH, POPE JH, EMANUEL ML, ROSS CJ
PubMed: 13239522
05/1955

The serological classification of 89 strains of Leptospirae from North Queensland, including five serotypes new to Australia.
SMITH DJ, BROWN HE, TONGE JI, SINNAMON CN, MACDONALD VM, ROSS CJ, DOHERTY RL
PubMed: 13159738
05/1954

Epidemiological observations on leptospirosis in North Queensland.
DERRICK EH, GORDON D, ROSS CJ, DOHERTY RL, SINNAMON CN, MACDONALD VM, KENNEDY JM
PubMed: 13159737
05/1954

Rocky Mountain spotted fever; case report and discussion of therapy.
GRAHAM GS, ROSS CJ
PubMed: 20285376
03/1947

Research

Canadian Pharmacogenomic Network for Drug Safety (CPNDS)
Canadian Institutes for Health Research (CIHR), Canada Foundation for Innovation (CFI), Genome British Columbia

The goal of CPNDS is to prevent adverse drug reactions (ADRs) in childhood by identifying predictive genomic markers for specific ADRs. Within five years, CPNDS intends to incorporate these markers into diagnostic tools that will be used to predict and prevent ADRs in children through specific dosing recommendations for commonly used drugs based on an individual's genetic make-up. The long-term goal for this project is to develop a user-friendly, and effective ADR monitoring tool and national database, to proactively prevent adverse drug reactions in susceptible children.

Specific projects seek to identify the key causal genetic factors of serious ADRs in children, including severe hearing loss caused by cisplatin chemotherapy; a lethal reaction to codeine in newborns and young children, anthracycline-induced heart failure, vincristine-induced peripheral neurotoxicity and drug-induced severe rash.

Grants

Pharmacogenetics of Warfarin Safety and Effectiveness in Children Canadian – CIHR (2012-2013)

Champions of Genetics New Investigator Award: Drug Safety Pharmacogenomics Evaluation (SAPHE) Initiative - Canadian Gene Cure Foundation (2012-2014)

Identification of pharmacogenomic variants for the prevention of vincristine-induced neurotoxicity – CIHR (2013-2014)

Honours & Awards

2012 - New Investigator Award, Canadian Institutes of Health Research

Research Group Members

Lin-hua Zhang
Britt Drogemoller
Galen Wright
Kristen Gibson
Jafar Hasbullah, Graduate Student
Erandika Prasadani Gunaretnam, Research Technician
Xiaohua Han
Erika Scott