- Overview
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I am interested in learning more about lung diseases that affect children.
My research is focused on finding the best way to diagnose and treat different types of asthma. I am particularly interested in learning about the reasons why some children have severe, treatment resistant asthma and finding ways to treat these children effectively. I am also interested in finding the best way to deliver asthma care to children across the province.
I am also involved in projects that look at the effectiveness of different types of therapies that we use for children with cystic fibrosis.
- Publications
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Dominant negative variants in IKZF2 cause ICHAD syndrome, a new disorder characterised by immunodysregulation, craniofacial anomalies, hearing impairment, athelia and developmental delay
Journal of Medical Genetics
DOI: 10.1136/jmg-2022-109127
2023Impact of Perinatal Exposure to SARS-CoV-2 Infection on Early Health Outcomes among Infants Born from 2020 to 2021 in British Columbia, Canada
Canadian Journal of Infectious Diseases and Medical Microbiology
DOI: 10.1155/2023/9968774
2023A germline heterozygous dominant negative IKZF2 variant causing syndromic primary immune regulatory disorder and ICHAD
medRxiv
DOI: 10.1101/2023.09.09.23295301
2023Which children are still dying from asthma? A 13 year review of pediatric asthma deaths in British Columbia, Canada
Pediatric Pulmonology
DOI: 10.1002/ppul.26441
2023SIMPLIFYing cystic fibrosis treatment in a post-modulator era
The Lancet Respiratory Medicine
DOI: 10.1016/S2213-2600(22)00480-5
2023Which children are still dying from asthma? A Thirteen Year Review of Pediatric Asthma Deaths in British Columbia, Canada
Connie Yang and * Cook and * Carleton and * Seear
DOI: 10.22541/au.166622763.36659960/v1
10/2022Asthma in the Americas: An Update A Joint Perspective from the Brazilian Thoracic Society, Canadian Thoracic Society, Latin American Thoracic Society, and American Thoracic Society
Annals of the American Thoracic Society
Forno, E. and Brandenburg, D.D. and Castro-Rodriguez, J.A. and Celis-Preciado, C.A. and Holguin, F. and Licskai, C. and Lovinsky-Desir, S. and Pizzichini, M. and Teper, A. and Yang, C. and Celedón, J.C.
DOI: 10.1513/AnnalsATS.202109-1068CME
2022Juvenile Dermatomyositis and Acute Respiratory Failure in a Teen
Chest
Kim, L.H. and Duncan, J. and Yang, C.L.
DOI: 10.1016/j.chest.2021.07.029
2021Factors influencing clinical trial participation for adult and pediatric patients with cystic fibrosis
Journal of Cystic Fibrosis
Lee, M. and Hu, X.Y. and Desai, S. and Kwong, E. and Fu, J. and Flores, E. and Lazosky, L. and Wilcox, P.G. and Mcllwaine, M. and Chilvers, M. and Yang, C. and Rayment, J.H. and Quon, B.S.
DOI: 10.1016/j.jcf.2020.08.019
2021Asthma
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Yang, C.L. and Ramsey, C.
DOI: 10.1080/24745332.2021.1899774
20212021 Canadian Thoracic Society Guideline–A focused update on the management of very mild and mild asthma
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Yang, C.L. and Hicks, E.A. and Mitchell, P. and Reisman, J. and Podgers, D. and Hayward, K.M. and Waite, M. and Ramsey, C.D.
DOI: 10.1080/24745332.2021.1877043
2021Canadian Thoracic Society 2021 Guideline update: Diagnosis and management of asthma in preschoolers, children and adults
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Yang, C.L. and Hicks, E.A. and Mitchell, P. and Reisman, J. and Podgers, D. and Hayward, K.M. and Waite, M. and Ramsey, C.D.
DOI: 10.1080/24745332.2021.1945887
2021Pan-Canadian standards for severe asthma in electronic medical records
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Lougheed, M.D. and Morra, A. and Bullock, E. and Tregobov, N. and Barber, D. and Boulet, L.-P. and Dell, S. and Ducharme, F.M. and Ferrone, M. and FitzGerald, J.M. and Gupta, S. and Licskai, C. and Podgers, D. and Nair, P. and Radhakrishnan, D. and Sadatsafavi, M. and Tamari, I.E. and To, T. and Walker, B. and Yang, C.L. and Lemiere, C.
DOI: 10.1080/24745332.2021.1947758
2021Dornase alfa for cystic fibrosis
Cochrane Database of Systematic Reviews
Yang, C. and Montgomery, M.
DOI: 10.1002/14651858.CD001127.pub5
2021Addressing therapeutic questions to help Canadian physicians optimize asthma management for their patients during the COVID-19 pandemic
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Licskai, C. and Yang, C.L. and Ducharme, F.M. and Radhakrishnan, D. and Podgers, D. and Ramsey, C. and Samanta, T. and Côté, A. and Mahdavian, M. and Lougheed, M.D.
DOI: 10.1080/24745332.2020.1754027
2020Canadian Thoracic Society recommendations regarding the use of face masks by the public during the SARS-CoV-2 (COVID-19) pandemic
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Bhutani, M. and Hernandez, P. and Yang, C. and Bourbeau, J. and Licskai, C. and Dechman, G. and Dam, A.V. and Gupta, S.
DOI: 10.1080/24745332.2020.1780897
2020Asthma and COVID-19
CMAJ
Abrams, E.M. and Jong, G.W. and Yang, C.L.
DOI: 10.1503/cmaj.200617
2020Asthma and COVID-19,L'asthme et la COVID-19
CMAJ
Abrams, E.M. and t'Jong, G.W. and Yang, C.L.
DOI: 10.1503/CMAJ.200617-F
2020Effectiveness of Intrapleural Tissue Plasminogen Activator and Dornase Alfa vs Tissue Plasminogen Activator Alone in Children with Pleural Empyema: A Randomized Clinical Trial
JAMA Pediatrics
Livingston, M.H. and Mahant, S. and Connolly, B. and Maclusky, I. and Laberge, S. and Giglia, L. and Yang, C. and Roberts, A. and Shawyer, A. and Brindle, M. and Parsons, S. and Stoian, C. and Walton, J.M. and Thorpe, K.E. and Chen, Y. and Zuo, F. and Mamdani, M. and Chan, C. and Loong, D. and Isaranuwatchai, W. and Ratjen, F. and Cohen, E.
DOI: 10.1001/jamapediatrics.2019.5863
2020Considerations regarding school return for children and adolescents with asthma: A Canadian Thoracic Society position statement
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Samanta, T. and Yang, C.L. and Radhakrishnan, D. and Lougheed, M.D. and Licskai, C. and Podgers, D. and Ramsey, C. and Côté, A. and Mahdavian, M. and Ducharme, F.M.
DOI: 10.1080/24745332.2020.1826754
2020Are the 2019 Global Initiative for Asthma (GINA) strategy recommendations applicable to the Canadian context?: A conversation between the Canadian Thoracic Society Asthma Assembly and Professor Helen Reddel, Chair of the GINA Scientific Committee
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Licskai, C. and Yang, C.L. and Lemiere, C. and Ducharme, F.M. and Lougheed, M.D. and Radhakrishnan, D. and Podgers, D. and Ramsey, C. and Samanta, T. and Côté, A. and Villa-Roel, C. and Van Dam, A. and Reddel, H.
DOI: 10.1080/24745332.2019.1679553
2020Key Highlights From the Canadian Thoracic Society Position Statement on the Optimization of Asthma Management During the Coronavirus Disease 2019 Pandemic
Chest
Licskai, C. and Yang, C.L. and Ducharme, F.M. and Radhakrishnan, D. and Podgers, D. and Ramsey, C. and Samanta, T. and Côté, A. and Mahdavian, M. and Lougheed, M.D.
DOI: 10.1016/j.chest.2020.05.551
2020Vitamin D in the prevention of exacerbations of asthma in preschoolers (DIVA): Protocol for a multicentre randomised placebo-controlled triple-blind trial
BMJ Open
Jensen, M.E. and Ducharme, F.M. and Alos, N. and Mailhot, G. and Mâsse, B. and White, J.H. and Sadatsafavi, M. and Khamessan, A. and Tse, S.M. and Alizadehfar, R. and Bock, D.E. and Daigneault, P. and Lemire, C. and Yang, C. and Radhakrishnan, D.
DOI: 10.1136/bmjopen-2019-033075
2019A Systematic Review of the Clinical Efficacy and Safety of CFTR Modulators in Cystic Fibrosis
Scientific Reports
Habib, A.-R.R. and Kajbafzadeh, M. and Desai, S. and Yang, C.L. and Skolnik, K. and Quon, B.S.
DOI: 10.1038/s41598-019-43652-2
2019An investigation into biomarkers for the diagnosis of ABPA and aspergillus disease in cystic fibrosis
Pediatric Pulmonology
Keown, K. and Abbott, S. and Kuzeljevic, B. and Rayment, J.H. and Chilvers, M.A. and Yang, C.L.
DOI: 10.1002/ppul.24465
2019Question 3: Can we diagnose asthma in children under the age of 5¿years?
Paediatric Respiratory Reviews
Yang, C.L. and Gaffin, J.M. and Radhakrishnan, D.
DOI: 10.1016/j.prrv.2018.10.003
2019In support of point-of-care social needs screening: The effects of five social determinants on the health of children with chronic diseases in British Columbia
Paediatrics and Child Health (Canada)
Seear, M. and Amed, S. and Dionne, J. and Yang, C. and Tourigny, K. and De Mello, A. and Hamilton, Z. and Espinosa, B.G.
DOI: 10.1093/pch/pxy090
2019Interstitial lung disease in infancy: an unusual presentation of CD40 ligand deficiency
LymphoSign Journal
Victoria Elizabeth Cook and Connie L Yang and Alexia Dabadie and Joanne Luider and Kyla Jade Hildebrand and Anne K Junker and Stuart Turvey
DOI: 10.14785/lymphosign-2017-0003
06/2017Forced expiratory values in 1 second corresponding to Pediatric Respiratory Assessment Measure and Acute Asthma Intensity Research Score values during pediatric acute asthma exacerbations
Annals of Allergy, Asthma and Immunology
Arnold, D.H. and Johnson, D.P. and Yang, C.L. and Hartert, T.V.
DOI: 10.1016/j.anai.2017.09.003
2017Misdiagnosis of asthma in schoolchildren
Pediatric Pulmonology
Yang, C.L. and Simons, E. and Foty, R.G. and Subbarao, P. and To, T. and Dell, S.D.
DOI: 10.1002/ppul.23541
2017Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): A study protocol for a randomized controlled trial
Trials
Livingston, M.H. and Mahant, S. and Ratjen, F. and Connolly, B.L. and Thorpe, K. and Mamdani, M. and Maclusky, I. and Laberge, S. and Giglia, L. and Walton, J.M. and Yang, C.L. and Roberts, A. and Shawyer, A.C. and Brindle, M. and Parsons, S.J. and Stoian, C.A. and Cohen, E.
DOI: 10.1186/s13063-017-2026-0
2017FOXP1 haploinsufficiency: Phenotypes beyond behavior and intellectual disability?
American Journal of Medical Genetics, Part A
Myers, A. and du Souich, C. and Yang, C.L. and Borovik, L. and Mwenifumbo, J. and Rupps, R. and Study, C.A.U.S.E.S. and Lehman, A. and Boerkoel, C.F.
DOI: 10.1002/ajmg.a.38462
2017Response to 'comment on the CTS 2015 guidelines for asthma in preschoolers'
Paediatrics and Child Health (Canada)
Yang, C.L.
DOI: 10.1093/pch/pxx138
2017Recognition and management of severe asthma: A Canadian Thoracic Society position statement
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
FitzGerald, J.M. and Lemiere, C. and Lougheed, M.D. and Ducharme, F.M. and Dell, S.D. and Ramsey, C. and Yang, M.C.L. and Côté, A. and Watson, W. and Olivenstein, R. and Van Dam, A. and Villa-Roel, C. and Grad, R.
DOI: 10.1080/24745332.2017.1395250
2017Respiratory Presentation of Pediatric Patients in the 2014 Enterovirus D68 Outbreak
Canadian Respiratory Journal
Martin, G. and Li, R. and Cook, V.E. and Carwana, M. and Tilley, P. and Sauve, L. and Tang, P. and Kapur, A. and Yang, C.L.
DOI: 10.1155/2016/8302179
2016Treatment of pulmonary exacerbations improves short but not long-term growth trajectory in children with cystic fibrosis
Journal of Pediatric Gastroenterology and Nutrition
Loong, C. and Breton, J. and Yang, C.L.
DOI: 10.1097/MPG.0000000000001311
2016Bleomycin-associated lung toxicity in childhood cancer survivors
Journal of Pediatric Hematology/Oncology
Zorzi, A.P. and Yang, C.L. and Dell, S. and Nathan, P.C.
DOI: 10.1097/MPH.0000000000000424
2015Prediction of childhood atopy by questionnaire
Clinical and Experimental Allergy
Simons, E. and Kwon, S. and Yang, C. and Dell, S.D.
DOI: 10.1111/cea.12510
2015Diagnosis and management of asthma in preschoolers: A Canadian Thoracic Society and Canadian Pediatric Society position paper,Le diagnostic et la prise en charge de l'asthme chez les enfants d'âge préscolaire : Document de principes la Société canadienne de thoracologie et la Société canadienne de pédiatrie
Paediatrics and Child Health (Canada)
Ducharme, F.M. and Dell, S.D. and Radhakrishnan, D. and Grad, R.M. and Watson, W.T.A. and Yang, C.L. and Zelman, M.
DOI: 10.1093/pch/20.7.362
2015Diagnosis and management of asthma in preschoolers: A Canadian Thoracic Society and Canadian Paediatric Society position paper
Canadian Respiratory Journal
Ducharme, F.M. and Dell, S.D. and Radhakrishnan, D. and Grad, R.M. and Watson, W.T.A. and Yang, C.L. and Zelman, M.
DOI: 10.1155/2015/101572
2015Embolization of a central venous catheter due to pinch-off syndrome
Acta Paediatrica, International Journal of Paediatrics
Gowraiah, V. and Culham, G. and Chilvers, M.A. and Yang, C.L.
DOI: 10.1111/apa.12085
2013Bronchial artery-pulmonary artery malformation as a cause of cryptogenic hemoptysis
Pediatric Pulmonology
Nugent, Z. and Oliveira, V. and Maclusky, I. and Amaral, J. and Connolly, B. and Yang, C.L.
DOI: 10.1002/ppul.22689
2013Administrative Databases Useful For Asthma Surveillance But Overestimate Asthma Prevalence
B61. PEDIATRIC ASTHMA
Connie L. Yang and Elinor Simons and Richard G. Foty and Teresa To and Sharon D. Dell
DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3363
05/2012Parental Report Of Asthma Diagnosis Superior To Exhaled Nitric Oxide For Measuring Childhood Asthma Prevalence
A59. ASTHMA
Connie L. Yang and Elinor Simons and Richard G. Foty and Teresa To and Sharon D. Dell
DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6361
05/2011Questionnaire Diagnosis Of Asthma Leads To Misclassification Compared To Guideline-Based Diagnosis
C106. PEDIATRIC ASTHMA
Connie L. Yang and Elinor Simons and Richard G. Foty and Laura Marshall and Kathleen Nelligan and Teresa To and Sharon D. Dell
DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5466
05/2011Verifying a questionnaire diagnosis of asthma in children using health claims data
BMC Pulmonary Medicine
Yang, C.L. and To, T. and Foty, R.G. and Stieb, D.M. and Dell, S.D.
DOI: 10.1186/1471-2466-11-52
2011Bicarbonate therapy improves growth in children with incomplete distal renal tubular acidosis
Pediatric Nephrology
Ajay P. Sharma and Ram N. Singh and Connie Yang and Raj K. Sharma and Rakesh Kapoor and Guido Filler
DOI: 10.1007/s00467-009-1169-y
04/2009 - Research
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Retrospective review on the use of intravenous lipids during cystic fibrosis exacerbations.
This project is reviewing if the use of lipids during admissions for cystic fibrosis exacerbations has any effect on short or long term nutrition.Safety of Inhaled Corticosteroids use in Children and in Pregnancy.
This large surveillance study will examine the safety profiles of different inhaled corticosteroids.Honours & AwardsInstitute of Medical Sciences Academic Development Award
Restracomp Research Competition Winner
Research Group MembersJohan Bouwer, FLEX Research Trainee
Crafting beating heart cells to deliver personalized treatments for kids with hypertrophic cardiomyopathy
Researchers at BC Children's Hospital Research Institute are working with human-induced pluripotent stem cells to develop safer and more effective treatments for kids with hypertrophic cardiomyopathy.
