Overview

I am interested in learning more about lung diseases that affect children.

My research is focused on finding the best way to diagnose and treat different types of asthma. I am particularly interested in learning about the reasons why some children have severe, treatment resistant asthma and finding ways to treat these children effectively. I am also interested in finding the best way to deliver asthma care to children across the province.

I am also involved in projects that look at the effectiveness of different types of therapies that we use for children with cystic fibrosis.

Publications

Asthma and COVID-19
CMAJ
Abrams, E.M. and Jong, G.W. and Yang, C.L.
DOI: 10.1503/cmaj.200617
2020

Canadian Thoracic Society recommendations regarding the use of face masks by the public during the SARS-CoV-2 (COVID-19) pandemic
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Bhutani, M. and Hernandez, P. and Yang, C. and Bourbeau, J. and Licskai, C. and Dechman, G. and Dam, A.V. and Gupta, S.
DOI: 10.1080/24745332.2020.1780897
2020

Are the 2019 Global Initiative for Asthma (GINA) strategy recommendations applicable to the Canadian context?: A conversation between the Canadian Thoracic Society Asthma Assembly and Professor Helen Reddel, Chair of the GINA Scientific Committee
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Licskai, C. and Yang, C.L. and Lemiere, C. and Ducharme, F.M. and Lougheed, M.D. and Radhakrishnan, D. and Podgers, D. and Ramsey, C. and Samanta, T. and C{\^o}t{\'e}, A. and Villa-Roel, C. and Van Dam, A. and Reddel, H.
DOI: 10.1080/24745332.2019.1679553
2020

Addressing therapeutic questions to help Canadian physicians optimize asthma management for their patients during the COVID-19 pandemic
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Licskai, C. and Yang, C.L. and Ducharme, F.M. and Radhakrishnan, D. and Podgers, D. and Ramsey, C. and Samanta, T. and C{\^o}t{\'e}, A. and Mahdavian, M. and Lougheed, M.D.
DOI: 10.1080/24745332.2020.1754027
2020

Effectiveness of Intrapleural Tissue Plasminogen Activator and Dornase Alfa vs Tissue Plasminogen Activator Alone in Children with Pleural Empyema: A Randomized Clinical Trial
JAMA Pediatrics
Livingston, M.H. and Mahant, S. and Connolly, B. and Maclusky, I. and Laberge, S. and Giglia, L. and Yang, C. and Roberts, A. and Shawyer, A. and Brindle, M. and Parsons, S. and Stoian, C. and Walton, J.M. and Thorpe, K.E. and Chen, Y. and Zuo, F. and Mamdani, M. and Chan, C. and Loong, D. and Isaranuwatchai, W. and Ratjen, F. and Cohen, E.
DOI: 10.1001/jamapediatrics.2019.5863
2020

An investigation into biomarkers for the diagnosis of ABPA and aspergillus disease in cystic fibrosis
Pediatric Pulmonology
Karen Keown and Salome Abbott and Boris Kuzeljevic and Jonathan H. Rayment and Mark A. Chilvers and Connie L. Yang
DOI: 10.1002/ppul.24465
11/2019

A Systematic Review of the Clinical Efficacy and Safety of CFTR Modulators in Cystic Fibrosis.
Scientific reports
Habib AR and Kajbafzadeh M and Desai S and Yang CL and Skolnik K and Quon BS
DOI: 10.1038/s41598-019-43652-2
PubMed: 31076617
05/2019

In support of point-of-care social needs screening: The effects of five social determinants on the health of children with chronic diseases in British Columbia
Paediatrics and Child Health (Canada)
Seear, M. and Amed, S. and Dionne, J. and Yang, C. and Tourigny, K. and De Mello, A. and Hamilton, Z. and Espinosa, B.G.
DOI: 10.1093/pch/pxy090
2019

Question 3: Can we diagnose asthma in children under the age of 5¿years?
Paediatric Respiratory Reviews
Yang, C.L. and Gaffin, J.M. and Radhakrishnan, D.
DOI: 10.1016/j.prrv.2018.10.003
2019

Vitamin D in the prevention of exacerbations of asthma in preschoolers (DIVA): Protocol for a multicentre randomised placebo-controlled triple-blind trial
BMJ Open
Jensen, M.E. and Ducharme, F.M. and Alos, N. and Mailhot, G. and M{\^a}sse, B. and White, J.H. and Sadatsafavi, M. and Khamessan, A. and Tse, S.M. and Alizadehfar, R. and Bock, D.E. and Daigneault, P. and Lemire, C. and Yang, C. and Radhakrishnan, D.
DOI: 10.1136/bmjopen-2019-033075
2019

Dornase alfa for cystic fibrosis.
The Cochrane database of systematic reviews
DOI: 10.1002/14651858.CD001127.pub4
PubMed: 30187450
09/2018

Response to ‘Comment on the CTS 2015 guidelines for asthma in preschoolers’
Paediatrics & Child Health
L Yang Connie
DOI: 10.1093/pch/pxx138
11/2017

Recognition and management of severe asthma: A Canadian Thoracic Society position statement
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
J. Mark FitzGerald and Catherine Lemiere and M. Diane Lougheed and Francine M. Ducharme and Sharon D. Dell and Clare Ramsey and M. Connie L. Yang and Andréanne Côté and Wade Watson and Ron Olivenstein and Anne Van Dam and Cristina Villa-Roel and Roland Grad
DOI: 10.1080/24745332.2017.1395250
10/2017

FOXP1 haploinsufficiency: Phenotypes beyond behavior and intellectual disability?
American journal of medical genetics. Part A
Myers A and du Souich C and Yang CL and Borovik L and Mwenifumbo J and Rupps R and Study C and Lehman A and Boerkoel CF
DOI: 10.1002/ajmg.a.38462
PubMed: 28884888
09/2017

Interstitial lung disease in infancy: an unusual presentation of CD40 ligand deficiency
LymphoSign Journal
Victoria Elizabeth Cook and Connie L Yang and Alexia Dabadie and Joanne Luider and Kyla Jade Hildebrand and Anne K Junker and Stuart Turvey
DOI: 10.14785/lymphosign-2017-0003
06/2017

Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial.
Trials
Livingston MH and Mahant S and Ratjen F and Connolly BL and Thorpe K and Mamdani M and Maclusky I and Laberge S and Giglia L and Walton JM and Yang CL and Roberts A and Shawyer AC and Cohen E
DOI: 10.1186/s13063-017-2026-0
PubMed: 28646887
06/2017

Forced expiratory values in 1 second corresponding to Pediatric Respiratory Assessment Measure and Acute Asthma Intensity Research Score values during pediatric acute asthma exacerbations
Annals of Allergy, Asthma & Immunology
Donald H. Arnold and David P. Johnson and Connie L. Yang and Tina V. Hartert
DOI: 10.1016/j.anai.2017.09.003
2017

Dornase alfa for cystic fibrosis
Paediatric Respiratory Reviews
Yang, C.L. and Chilvers, M. and Montgomery, M. and Nolan, S.J.
DOI: 10.1016/j.prrv.2016.09.001
2017

Misdiagnosis of asthma in schoolchildren
Pediatric Pulmonology
Yang, C.L. and Simons, E. and Foty, R.G. and Subbarao, P. and To, T. and Dell, S.D.
DOI: 10.1002/ppul.23541
2017

Treatment of Pulmonary Exacerbations Improves Short But Not Long-Term Growth Trajectory in Children With Cystic Fibrosis
Journal of Pediatric Gastroenterology and Nutrition
Christine Loong and Jessica Breton and Connie L. Yang
DOI: 10.1097/mpg.0000000000001311
10/2016

Dornase alfa for cystic fibrosis
Cochrane Database of Systematic Reviews
Connie Yang and Mark Chilvers and Mark Montgomery and Sarah J Nolan
DOI: 10.1002/14651858.cd001127.pub3
04/2016

Respiratory Presentation of Pediatric Patients in the 2014 Enterovirus D68 Outbreak
Canadian Respiratory Journal
Georgina Martin and Rachel Li and Victoria E. Cook and Matthew Carwana and Peter Tilley and Laura Sauve and Patrick Tang and Akshat Kapur and Connie L. Yang
DOI: 10.1155/2016/8302179
2016

Dornase alfa for cystic fibrosis
Cochrane Database of Systematic Reviews
Yang, C. and Chilvers, M. and Montgomery, M. and Nolan, S.J.
DOI: 10.1002/14651858.CD001127.pub3
2016

Treatment of pulmonary exacerbations improves short but not long-term growth trajectory in children with cystic fibrosis
Journal of Pediatric Gastroenterology and Nutrition
Loong, C. and Breton, J. and Yang, C.L.
DOI: 10.1097/MPG.0000000000001311
2016

Bleomycin-associated Lung Toxicity in Childhood Cancer Survivors
Journal of Pediatric Hematology/Oncology
Alexandra P. Zorzi and Connie L. Yang and Sharon Dell and Paul C. Nathan
DOI: 10.1097/mph.0000000000000424
11/2015

Diagnosis and management of asthma in preschoolers: A Canadian Thoracic Society and Canadian Paediatric Society position paper
Paediatrics & Child Health
Francine M Ducharme and Sharon D Dell and Dhenuka Radhakrishnan and Roland M Grad and Wade TA Watson and Connie L Yang and Mitchell Zelman
DOI: 10.1093/pch/20.7.353
10/2015

Diagnosis and Management of Asthma in Preschoolers: A Canadian Thoracic Society and Canadian Paediatric Society Position Paper
Canadian Respiratory Journal
Francine M Ducharme and Sharon D Dell and Dhenuka Radhakrishnan and Roland M Grad and Wade TA Watson and Connie L Yang and Mitchell Zelman
DOI: 10.1155/2015/101572
2015

Prediction of childhood atopy by questionnaire
Clinical and Experimental Allergy
Simons, E. and Kwon, S. and Yang, C. and Dell, S.D.
DOI: 10.1111/cea.12510
2015

Diagnosis and management of asthma in preschoolers: A Canadian Thoracic Society and Canadian Pediatric Society position paper,Le diagnostic et la prise en charge de l'asthme chez les enfants d'âge préscolaire : Document de principes la Société canadienne de thoracologie et la Société canadienne de pédiatrie
Paediatrics and Child Health (Canada)
Ducharme, F.M. and Dell, S.D. and Radhakrishnan, D. and Grad, R.M. and Watson, W.T.A. and Yang, C.L. and Zelman, M.
DOI: 10.1093/pch/20.7.362
2015

Bleomycin-associated lung toxicity in childhood cancer survivors
Journal of Pediatric Hematology/Oncology
Zorzi, A.P. and Yang, C.L. and Dell, S. and Nathan, P.C.
DOI: 10.1097/MPH.0000000000000424
2015

Bronchial artery-pulmonary artery malformation as a cause of cryptogenic hemoptysis
Pediatric Pulmonology
Nugent, Z. and Oliveira, V. and Maclusky, I. and Amaral, J. and Connolly, B. and Yang, C.L.
DOI: 10.1002/ppul.22689
2013

Embolization of a central venous catheter due to pinch-off syndrome
Acta Paediatrica, International Journal of Paediatrics
Gowraiah, V. and Culham, G. and Chilvers, M.A. and Yang, C.L.
DOI: 10.1111/apa.12085
2013

Administrative Databases Useful For Asthma Surveillance But Overestimate Asthma Prevalence
B61. PEDIATRIC ASTHMA
Connie L. Yang and Elinor Simons and Richard G. Foty and Teresa To and Sharon D. Dell
DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3363
05/2012

Verifying a questionnaire diagnosis of asthma in children using health claims data
BMC Pulmonary Medicine
Connie L Yang and Teresa To and Richard G Foty and David M Stieb and Sharon D Dell
DOI: 10.1186/1471-2466-11-52
11/2011

Parental Report Of Asthma Diagnosis Superior To Exhaled Nitric Oxide For Measuring Childhood Asthma Prevalence
A59. ASTHMA
Connie L. Yang and Elinor Simons and Richard G. Foty and Teresa To and Sharon D. Dell
DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6361
05/2011

Questionnaire Diagnosis Of Asthma Leads To Misclassification Compared To Guideline-Based Diagnosis
C106. PEDIATRIC ASTHMA
Connie L. Yang and Elinor Simons and Richard G. Foty and Laura Marshall and Kathleen Nelligan and Teresa To and Sharon D. Dell
DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5466
05/2011

Bicarbonate therapy improves growth in children with incomplete distal renal tubular acidosis
Pediatric Nephrology
Ajay P. Sharma and Ram N. Singh and Connie Yang and Raj K. Sharma and Rakesh Kapoor and Guido Filler
DOI: 10.1007/s00467-009-1169-y
04/2009

Research

Retrospective review on the use of intravenous lipids during cystic fibrosis exacerbations.
This project is reviewing if the use of lipids during admissions for cystic fibrosis exacerbations has any effect on short or long term nutrition.

Safety of Inhaled Corticosteroids use in Children and in Pregnancy.
This large surveillance study will examine the safety profiles of different inhaled corticosteroids.

Honours & Awards

Institute of Medical Sciences Academic Development Award

Restracomp Research Competition Winner