Connie Yang

MSc, MD

Affiliate Investigator, BC Children's Hospital

I am interested in learning more about lung diseases that affect children.

My research is focused on finding the best way to diagnose and treat different types of asthma. I am particularly interested in learning about the reasons why some children have severe, treatment resistant asthma and finding ways to treat these children effectively. I am also interested in finding the best way to deliver asthma care to children across the province.

I am also involved in projects that look at the effectiveness of different types of therapies that we use for children with cystic fibrosis.

Academic Affiliations

  • Clinical Associate Professor, Division of Respiratory Medicine, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Childhood Diseases
  • Research Group(s): Clinical Practice, Outcomes and Innovation; Clinical and Community Data, Analytics and Informatics; Immunity in Health and Disease; Implementing Knowledge for Equity and System Change

Contact Information

Location

555 University Avenue, Toronto, ON, Canada, M5G 1X8

Risk Factors for Severe Disease Among Children Hospitalized With Respiratory Syncytial Virus

JAMA Network Open

Kirolos, N. and Mtaweh, H. and Datta, R.R. and Farrar, D.S. and Seaton, C. and Bone, J.N. and Muttalib, F. and Kaziev, C.L. and Fortini, J. and Mahant, S. and Campigotto, A. and Freire, G. and Yeung, R.S.M. and Rayment, J.H. and Yang, C. and Srigley, J.A. and Sadarangani, M. and Buchanan, F. and Morris, S.K. and Gill, P.J.

DOI: 10.1001/jamanetworkopen.2025.4666

A multimorphic variant in ThPOK causes an inborn error of immunity with T cell defects and fibrosis

Journal of Experimental Medicine

Vaseghi-Shanjani, M. and Sharma, M. and Yousefi, P. and Samra, S. and Laverty, K.U. and Jolma, A. and Razavi, R. and Yang, A.H.W. and Albu, M. and Golding, L. and Lee, A.F. and Tan, R. and Richmond, P.A. and Bosticardo, M. and Rayment, J.H. and Yang, C.L. and Hildebrand, K.J. and Brager, R. and Demos, M.K. and Lau, Y.-L. and Notarangelo, L.D. and Hughes, T.R. and Biggs, C.M. and Turvey, S.E.

DOI: 10.1084/jem.20241174

Long-term health outcomes of preterm birth: a narrative review

Frontiers in Pediatrics

Gette, F. and Aziz Ali, S. and Ho, M.S.P. and Richter, L.L. and Chan, E.S. and Yang, C.L. and Kieran, E. and Mammen, C. and Roberts, A. and Kang, K.T. and Wong, J. and Rassekh, S.R. and Castaldo, M. and Harris, K.C. and Lee, J. and Lam, C.K.L. and Chan, N.H. and Lisonkova, S. and Ting, J.Y.

DOI: 10.3389/fped.2025.1565897

A Germline Heterozygous Dominant Negative IKZF2 Variant Causing Syndromic Primary Immune Regulatory Disorder and ICHAD

Journal of Clinical Immunology

Lu, H.Y. and Vaseghi-Shanjani, M. and Lam, A.J. and Sharma, M. and Mohajeri, A. and Silva, L.B.R. and Gillies, J. and Yang, G.X. and Lin, S. and Fu, M.P. and Salman, A. and Rahmanian, R. and Armstrong, L. and Halparin, J. and Yang, C.L. and Chilvers, M. and Henkelman, E. and Rehmus, W. and Morrison, D. and Setiadi, A. and Mostafavi, S. and Kobor, M.S. and Kozak, F.K. and Biggs, C.M. and van Karnebeek, C. and Hildebrand, K.J. and Levings, M.K. and Turvey, S.E.

DOI: 10.1007/s10875-025-01882-2

A multimorphic variant in ThPOK causes a novel human disease characterized by T cell abnormalities, immunodysregulation, allergy, and fibrosis

medRxiv

Vaseghi-Shanjani, M. and Sharma, M. and Yousefi, P. and Samra, S. and Laverty, K.U. and Jolma, A. and Razavi, R. and Yang, A.H.W. and Albu, M. and Golding, L. and Lee, A.F. and Tan, R. and Richmond, P.A. and Bosticardo, M. and Rayment, J.H. and Yang, C.L. and Hildebrand, K.J. and Brager, R. and Demos, M.K. and Lau, Y.L. and Notarangelo, L.D. and Hughes, T.R. and Biggs, C.M. and Turvey, S.E.

DOI: 10.1101/2024.06.26.24309360

The management of very mild and mild asthma in preschoolers, children, and adolescents

Paediatrics and Child Health (Canada)

Yang, C.L. and Zysman-Colman, Z. and Chtrit, E. and Hicks, A. and Reisman, J. and Glicksman, A.

DOI: 10.1093/pch/pxae006

The management of mild and very mild asthma in preschool children, children and adolescents,La prise en charge de lasthme lger et trs lger chez les enfants dge prscolaire, les enfants et les adolescents

Paediatrics and Child Health (Canada)

Yang, C.L. and Zysman-Colman, Z. and Chtrit, E. and Hicks, A. and Reisman, J. and Glicksman, A.

DOI: 10.1093/pch/pxae005

Expanding the molecular and phenotypic spectrum of CTLA-4 insufficiency

Pediatric Allergy and Immunology

Duke, S. and Maiarana, J. and Yousefi, P. and Burks, E. and Gerrie, S. and Setiadi, A. and Amid, A. and Boerkel, C. and Erdle, S. and Guttman, O. and Kanani, A. and Lawrence, S. and Lee, A.F. and Pourshahnazari, P. and Rayar, M. and Rozmus, J. and Schrader, D. and Sharma, M. and Shopsowitz, K.E. and Tan, R. and To, F. and Yang, C. and Hildebrand, K.J. and James, E. and Turvey, S.E. and Markle, J.G. and Biggs, C.M.

DOI: 10.1111/pai.14077

Dominant negative variants in IKZF2 cause ICHAD syndrome, a new disorder characterised by immunodysregulation, craniofacial anomalies, hearing impairment, athelia and developmental delay

Journal of Medical Genetics

Mohajeri, A. and Vaseghi-Shanjani, M. and Rosenfeld, J.A. and Yang, G.X. and Lu, H. and Sharma, M. and Lin, S. and Salman, A. and Waqas, M. and Sababi Azamian, M. and Worley, K.C. and Del Bel, K.L. and Kozak, F.K. and Rahmanian, R. and Biggs, C.M. and Hildebrand, K.J. and Lalani, S.R. and Nicholas, S.K. and Scott, D.A. and Mostafavi, S. and Van Karnebeek, C. and Henkelman, E. and Halparin, J. and Yang, C.L. and Armstrong, L. and Turvey, S.E. and Lehman, A.

DOI: 10.1136/jmg-2022-109127

Individualized treatment strategies and considerations in patients with mild asthma: Discussion of Canadian Thoracic Society guideline recommendations,Stratgies thrapeutiques individualises et facteurs considrer chez les patients atteints dasthme lger

Canadian Family Physician

Waite, M.E. and Yang, C.L.

DOI: 10.46747/cfp.6912833

Impact of Perinatal Exposure to SARS-CoV-2 Infection on Early Health Outcomes among Infants Born from 2020 to 2021 in British Columbia, Canada

Canadian Journal of Infectious Diseases and Medical Microbiology

Richter, L.L. and Ho, M.S.P. and Zhang, Q. and Bone, J.N. and Portales-Casamar, E. and Yang, C.L. and Roberts, A. and Kang, K. and Kieran, E. and Lam, C. and Lisonkova, S. and Ting, J.Y.

DOI: 10.1155/2023/9968774

Individualized treatment strategies and considerations in patients with mild asthma Discussion of Canadian Thoracic Society guideline recommendations

Canadian Family Physician

Waite, M.E. and Yang, C.L.

DOI: 10.46747/cfp.6912829

Which children are still dying from asthma? A 13 year review of pediatric asthma deaths in British Columbia, Canada

Pediatric Pulmonology

Cook, V.E. and Seear, M. and Carleton, B. and Yang, C.L.

DOI: 10.1002/ppul.26441

SIMPLIFYing cystic fibrosis treatment in a post-modulator era

The Lancet Respiratory Medicine

Yang, C.

DOI: 10.1016/S2213-2600(22)00480-5

Which children are still dying from asthma? A Thirteen Year Review of Pediatric Asthma Deaths in British Columbia, Canada

Connie Yang and * Cook and * Carleton and * Seear

DOI: 10.22541/au.166622763.36659960/v1

10 / 2022

Asthma in the Americas: An Update A Joint Perspective from the Brazilian Thoracic Society, Canadian Thoracic Society, Latin American Thoracic Society, and American Thoracic Society

Annals of the American Thoracic Society

Forno, E. and Brandenburg, D.D. and Castro-Rodriguez, J.A. and Celis-Preciado, C.A. and Holguin, F. and Licskai, C. and Lovinsky-Desir, S. and Pizzichini, M. and Teper, A. and Yang, C. and Celedn, J.C.

DOI: 10.1513/AnnalsATS.202109-1068CME

Juvenile Dermatomyositis and Acute Respiratory Failure in a Teen

Chest

Kim, L.H. and Duncan, J. and Yang, C.L.

DOI: 10.1016/j.chest.2021.07.029

Factors influencing clinical trial participation for adult and pediatric patients with cystic fibrosis

Journal of Cystic Fibrosis

Lee, M. and Hu, X.Y. and Desai, S. and Kwong, E. and Fu, J. and Flores, E. and Lazosky, L. and Wilcox, P.G. and Mcllwaine, M. and Chilvers, M. and Yang, C. and Rayment, J.H. and Quon, B.S.

DOI: 10.1016/j.jcf.2020.08.019

Asthma

Canadian Journal of Respiratory, Critical Care, and Sleep Medicine

Yang, C.L. and Ramsey, C.

DOI: 10.1080/24745332.2021.1899774

2021 Canadian Thoracic Society Guideline"A focused update on the management of very mild and mild asthma

Canadian Journal of Respiratory, Critical Care, and Sleep Medicine

Yang, C.L. and Hicks, E.A. and Mitchell, P. and Reisman, J. and Podgers, D. and Hayward, K.M. and Waite, M. and Ramsey, C.D.

DOI: 10.1080/24745332.2021.1877043

Canadian Thoracic Society 2021 Guideline update: Diagnosis andmanagement of asthma in preschoolers, children and adults

Canadian Journal of Respiratory, Critical Care, and Sleep Medicine

Yang, C.L. and Hicks, E.A. and Mitchell, P. and Reisman, J. and Podgers, D. and Hayward, K.M. and Waite, M. and Ramsey, C.D.

DOI: 10.1080/24745332.2021.1945887

Pan-Canadian standards for severe asthma in electronic medical records

Canadian Journal of Respiratory, Critical Care, and Sleep Medicine

Lougheed, M.D. and Morra, A. and Bullock, E. and Tregobov, N. and Barber, D. and Boulet, L.-P. and Dell, S. and Ducharme, F.M. and Ferrone, M. and FitzGerald, J.M. and Gupta, S. and Licskai, C. and Podgers, D. and Nair, P. and Radhakrishnan, D. and Sadatsafavi, M. and Tamari, I.E. and To, T. and Walker, B. and Yang, C.L. and Lemiere, C.

DOI: 10.1080/24745332.2021.1947758

Dornase alfa for cystic fibrosis

Cochrane Database of Systematic Reviews

Yang, C. and Montgomery, M.

DOI: 10.1002/14651858.CD001127.pub5

Addressing therapeutic questions to help Canadian physicians optimize asthma management for their patients during the COVID-19 pandemic

Canadian Journal of Respiratory, Critical Care, and Sleep Medicine

Licskai, C. and Yang, C.L. and Ducharme, F.M. and Radhakrishnan, D. and Podgers, D. and Ramsey, C. and Samanta, T. and Ct, A. and Mahdavian, M. and Lougheed, M.D.

DOI: 10.1080/24745332.2020.1754027

Canadian Thoracic Society recommendations regarding the use of face masks by the public during the SARS-CoV-2 (COVID-19) pandemic

Canadian Journal of Respiratory, Critical Care, and Sleep Medicine

Bhutani, M. and Hernandez, P. and Yang, C. and Bourbeau, J. and Licskai, C. and Dechman, G. and Dam, A.V. and Gupta, S.

DOI: 10.1080/24745332.2020.1780897

Asthma and COVID-19

CMAJ

Abrams, E.M. and Jong, G.W. and Yang, C.L.

DOI: 10.1503/cmaj.200617

Asthma and COVID-19,L'asthme et la COVID-19

CMAJ

Abrams, E.M. and t'Jong, G.W. and Yang, C.L.

DOI: 10.1503/CMAJ.200617-F

Effectiveness of Intrapleural Tissue Plasminogen Activator and Dornase Alfa vs Tissue Plasminogen Activator Alone in Children with Pleural Empyema: A Randomized Clinical Trial

JAMA Pediatrics

Livingston, M.H. and Mahant, S. and Connolly, B. and Maclusky, I. and Laberge, S. and Giglia, L. and Yang, C. and Roberts, A. and Shawyer, A. and Brindle, M. and Parsons, S. and Stoian, C. and Walton, J.M. and Thorpe, K.E. and Chen, Y. and Zuo, F. and Mamdani, M. and Chan, C. and Loong, D. and Isaranuwatchai, W. and Ratjen, F. and Cohen, E.

DOI: 10.1001/jamapediatrics.2019.5863

Considerations regarding school return for children and adolescents with asthma: A Canadian Thoracic Society position statement

Canadian Journal of Respiratory, Critical Care, and Sleep Medicine

Samanta, T. and Yang, C.L. and Radhakrishnan, D. and Lougheed, M.D. and Licskai, C. and Podgers, D. and Ramsey, C. and Ct, A. and Mahdavian, M. and Ducharme, F.M.

DOI: 10.1080/24745332.2020.1826754

Are the 2019 Global Initiative for Asthma (GINA) strategy recommendations applicable to the Canadian context?: A conversation between the Canadian Thoracic Society Asthma Assembly and Professor Helen Reddel, Chair of the GINA Scientific Committee

Canadian Journal of Respiratory, Critical Care, and Sleep Medicine

Licskai, C. and Yang, C.L. and Lemiere, C. and Ducharme, F.M. and Lougheed, M.D. and Radhakrishnan, D. and Podgers, D. and Ramsey, C. and Samanta, T. and Ct, A. and Villa-Roel, C. and Van Dam, A. and Reddel, H.

DOI: 10.1080/24745332.2019.1679553

Key Highlights From the Canadian Thoracic Society Position Statement on the Optimization of Asthma Management During the Coronavirus Disease 2019 Pandemic

Chest

Licskai, C. and Yang, C.L. and Ducharme, F.M. and Radhakrishnan, D. and Podgers, D. and Ramsey, C. and Samanta, T. and Ct, A. and Mahdavian, M. and Lougheed, M.D.

DOI: 10.1016/j.chest.2020.05.551

Vitamin D in the prevention of exacerbations of asthma in preschoolers (DIVA): Protocol for a multicentre randomised placebo-controlled triple-blind trial

BMJ Open

Jensen, M.E. and Ducharme, F.M. and Alos, N. and Mailhot, G. and Msse, B. and White, J.H. and Sadatsafavi, M. and Khamessan, A. and Tse, S.M. and Alizadehfar, R. and Bock, D.E. and Daigneault, P. and Lemire, C. and Yang, C. and Radhakrishnan, D.

DOI: 10.1136/bmjopen-2019-033075

A Systematic Review of the Clinical Efficacy and Safety of CFTR Modulators in Cystic Fibrosis

Scientific Reports

Habib, A.-R.R. and Kajbafzadeh, M. and Desai, S. and Yang, C.L. and Skolnik, K. and Quon, B.S.

DOI: 10.1038/s41598-019-43652-2

An investigation into biomarkers for the diagnosis of ABPA and aspergillus disease in cystic fibrosis

Pediatric Pulmonology

Keown, K. and Abbott, S. and Kuzeljevic, B. and Rayment, J.H. and Chilvers, M.A. and Yang, C.L.

DOI: 10.1002/ppul.24465

Question 3: Can we diagnose asthma in children under the age of 5years?

Paediatric Respiratory Reviews

Yang, C.L. and Gaffin, J.M. and Radhakrishnan, D.

DOI: 10.1016/j.prrv.2018.10.003

In support of point-of-care social needs screening: The effects of five social determinants on the health of children with chronic diseases in British Columbia

Paediatrics and Child Health (Canada)

Seear, M. and Amed, S. and Dionne, J. and Yang, C. and Tourigny, K. and De Mello, A. and Hamilton, Z. and Espinosa, B.G.

DOI: 10.1093/pch/pxy090

Interstitial lung disease in infancy: an unusual presentation of CD40 ligand deficiency

LymphoSign Journal

Victoria Elizabeth Cook and Connie L Yang and Alexia Dabadie and Joanne Luider and Kyla Jade Hildebrand and Anne K Junker and Stuart Turvey

DOI: 10.14785/lymphosign-2017-0003

06 / 2017

Forced expiratory values in 1 second corresponding to Pediatric Respiratory Assessment Measure and Acute Asthma Intensity Research Score values during pediatric acute asthma exacerbations

Annals of Allergy, Asthma and Immunology

Arnold, D.H. and Johnson, D.P. and Yang, C.L. and Hartert, T.V.

DOI: 10.1016/j.anai.2017.09.003

Misdiagnosis of asthma in schoolchildren

Pediatric Pulmonology

Yang, C.L. and Simons, E. and Foty, R.G. and Subbarao, P. and To, T. and Dell, S.D.

DOI: 10.1002/ppul.23541

Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): A study protocol for a randomized controlled trial

Trials

Livingston, M.H. and Mahant, S. and Ratjen, F. and Connolly, B.L. and Thorpe, K. and Mamdani, M. and Maclusky, I. and Laberge, S. and Giglia, L. and Walton, J.M. and Yang, C.L. and Roberts, A. and Shawyer, A.C. and Brindle, M. and Parsons, S.J. and Stoian, C.A. and Cohen, E.

DOI: 10.1186/s13063-017-2026-0

FOXP1 haploinsufficiency: Phenotypes beyond behavior and intellectual disability?

American Journal of Medical Genetics, Part A

Myers, A. and du Souich, C. and Yang, C.L. and Borovik, L. and Mwenifumbo, J. and Rupps, R. and Study, C.A.U.S.E.S. and Lehman, A. and Boerkoel, C.F.

DOI: 10.1002/ajmg.a.38462

Response to 'comment on the CTS 2015 guidelines for asthma in preschoolers'

Paediatrics and Child Health (Canada)

Yang, C.L.

DOI: 10.1093/pch/pxx138

Recognition and management of severe asthma: A Canadian Thoracic Society position statement

Canadian Journal of Respiratory, Critical Care, and Sleep Medicine

FitzGerald, J.M. and Lemiere, C. and Lougheed, M.D. and Ducharme, F.M. and Dell, S.D. and Ramsey, C. and Yang, M.C.L. and Ct, A. and Watson, W. and Olivenstein, R. and Van Dam, A. and Villa-Roel, C. and Grad, R.

DOI: 10.1080/24745332.2017.1395250

Respiratory Presentation of Pediatric Patients in the 2014 Enterovirus D68 Outbreak

Canadian Respiratory Journal

Martin, G. and Li, R. and Cook, V.E. and Carwana, M. and Tilley, P. and Sauve, L. and Tang, P. and Kapur, A. and Yang, C.L.

DOI: 10.1155/2016/8302179

Treatment of pulmonary exacerbations improves short but not long-term growth trajectory in children with cystic fibrosis

Journal of Pediatric Gastroenterology and Nutrition

Loong, C. and Breton, J. and Yang, C.L.

DOI: 10.1097/MPG.0000000000001311

Bleomycin-associated lung toxicity in childhood cancer survivors

Journal of Pediatric Hematology/Oncology

Zorzi, A.P. and Yang, C.L. and Dell, S. and Nathan, P.C.

DOI: 10.1097/MPH.0000000000000424

Prediction of childhood atopy by questionnaire

Clinical and Experimental Allergy

Simons, E. and Kwon, S. and Yang, C. and Dell, S.D.

DOI: 10.1111/cea.12510

Diagnosis and management of asthma in preschoolers: A Canadian Thoracic Society and Canadian Pediatric Society position paper,Le diagnostic et la prise en charge de l'asthme chez les enfants d'ge prscolaire : Document de principes la Socit canadienne de thoracologie et la Socit canadienne de pdiatrie

Paediatrics and Child Health (Canada)

Ducharme, F.M. and Dell, S.D. and Radhakrishnan, D. and Grad, R.M. and Watson, W.T.A. and Yang, C.L. and Zelman, M.

DOI: 10.1093/pch/20.7.362

Diagnosis and management of asthma in preschoolers: A Canadian Thoracic Society and Canadian Paediatric Society position paper

Canadian Respiratory Journal

Ducharme, F.M. and Dell, S.D. and Radhakrishnan, D. and Grad, R.M. and Watson, W.T.A. and Yang, C.L. and Zelman, M.

DOI: 10.1155/2015/101572

Embolization of a central venous catheter due to pinch-off syndrome

Acta Paediatrica, International Journal of Paediatrics

Gowraiah, V. and Culham, G. and Chilvers, M.A. and Yang, C.L.

DOI: 10.1111/apa.12085

Bronchial artery-pulmonary artery malformation as a cause of cryptogenic hemoptysis

Pediatric Pulmonology

Nugent, Z. and Oliveira, V. and Maclusky, I. and Amaral, J. and Connolly, B. and Yang, C.L.

DOI: 10.1002/ppul.22689

Administrative Databases Useful For Asthma Surveillance But Overestimate Asthma Prevalence

B61. PEDIATRIC ASTHMA

Connie L. Yang and Elinor Simons and Richard G. Foty and Teresa To and Sharon D. Dell

DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3363

05 / 2012

Parental Report Of Asthma Diagnosis Superior To Exhaled Nitric Oxide For Measuring Childhood Asthma Prevalence

A59. ASTHMA

Connie L. Yang and Elinor Simons and Richard G. Foty and Teresa To and Sharon D. Dell

DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6361

05 / 2011

Questionnaire Diagnosis Of Asthma Leads To Misclassification Compared To Guideline-Based Diagnosis

C106. PEDIATRIC ASTHMA

Connie L. Yang and Elinor Simons and Richard G. Foty and Laura Marshall and Kathleen Nelligan and Teresa To and Sharon D. Dell

DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5466

05 / 2011

Verifying a questionnaire diagnosis of asthma in children using health claims data

BMC Pulmonary Medicine

Yang, C.L. and To, T. and Foty, R.G. and Stieb, D.M. and Dell, S.D.

DOI: 10.1186/1471-2466-11-52

Bicarbonate therapy improves growth in children with incomplete distal renal tubular acidosis

Pediatric Nephrology

Ajay P. Sharma and Ram N. Singh and Connie Yang and Raj K. Sharma and Rakesh Kapoor and Guido Filler

DOI: 10.1007/s00467-009-1169-y

04 / 2009

Retrospective review on the use of intravenous lipids during cystic fibrosis exacerbations.

This project is reviewing if the use of lipids during admissions for cystic fibrosis exacerbations has any effect on short or long term nutrition.

Safety of Inhaled Corticosteroids use in Children and in Pregnancy.

This large surveillance study will examine the safety profiles of different inhaled corticosteroids.

Honours & Awards

Institute of Medical Sciences Academic Development Award

Restracomp Research Competition Winner

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Stay in the Know

Sign up for compelling stories about innovative science, the doctors and researchers who turn ideas into discoveries and treatments, and the kids and families whose lives are changed.

This field is for validation purposes and should be left unchanged.