Overview

Our research program has focused on defining mechanisms of abnormal kidney development. We are now applying this knowledge to our understanding of the causes of common childhood kidney diseases and towards identifying specific characteristics that predict long-term outcomes. Using a variety of experimental models we are advancing knowledge in this area and, in particular, highlighting the kidney collecting duct as an important player in kidney injury and repair. Our work is demonstrating that the severity of in utero kidney injury predicts long-term kidney outcome and the risk of developing end stage kidney disease. In addition we have established a Clinical Pathway Development (CPD) team to help translate these and other innovative research findings into best practices and standardized clinical care.

Publications

Induction prednisone dosing for childhood nephrotic syndrome: how low should we go?
Pediatric Nephrology
Sibley, M. and Roshan, A. and Alshami, A. and Catapang, M. and J{\"o}bsis, J.J. and Kwok, T. and Polderman, N. and Sibley, J. and Matsell, D.G. and Mammen, C.
DOI: 10.1007/s00467-018-3975-6
2018

Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy
Physiological Reports
Maydan, O. and McDade, P.G. and Liu, Y. and Wu, X.-R. and Matsell, D.G. and Eddy, A.A.
DOI: 10.14814/phy2.13654
2018

A Randomized Trial of a Multicomponent Intervention to Promote Medication Adherence: The Teen Adherence in Kidney Transplant Effectiveness of Intervention Trial (TAKE-IT)
American Journal of Kidney Diseases
Foster, B.J. and Pai, A.L.H. and Zelikovsky, N. and Amaral, S. and Bell, L. and Dharnidharka, V.R. and Hebert, D. and Holly, C. and Knauper, B. and Matsell, D. and Phan, V. and Rogers, R. and Smith, J.M. and Zhao, H. and Furth, S.L.
DOI: 10.1053/j.ajkd.2017.12.012
2018

Acute kidney injury in children with sickle cell disease—compounding a chronic problem
Pediatric Nephrology
Mammen, C. and Bissonnette, M.L. and Matsell, D.G.
DOI: 10.1007/s00467-017-3650-3
2017

Indications for kidney biopsy in idiopathic childhood nephrotic syndrome
Pediatric Nephrology
Alshami, A. and Roshan, A. and Catapang, M. and J{\"o}bsis, J.J. and Kwok, T. and Polderman, N. and Sibley, J. and Sibley, M. and Mammen, C. and Matsell, D.G.
DOI: 10.1007/s00467-017-3687-3
2017

Antenatal Determinants of Long-Term Kidney Outcome in Boys with Posterior Urethral Valves
Fetal Diagnosis and Therapy
Matsell, D.G. and Yu, S. and Morrison, S.J.
DOI: 10.1159/000439302
2016

The impact of small kidneys
Pediatric Nephrology
Matsell, D.G. and Cojocaru, D. and Matsell, E.W. and Eddy, A.A.
DOI: 10.1007/s00467-015-3079-5
2015

Tacrolimus therapeutic drug monitoring and pediatric renal transplant graft outcomes
Pediatric Transplantation
Larkins, N. and Matsell, D.G.
DOI: 10.1111/petr.12369
2014

Chylous pericardial effusion in granulomatosis with polyangiitis
Nephrology
Larkins, N. and Harris, K.C. and Morishita, K. and Matsell, D.G.
DOI: 10.1111/nep.12262
2014

Urinary tract obstruction in the mouse: The kinetics of distal nephron injury
Laboratory Investigation
Hiatt, M.J. and Ivanova, L. and Trnka, P. and Solomon, M. and Matsell, D.G.
DOI: 10.1038/labinvest.2013.90
2013

Epidemiology of cardiac surgery-associated acute kidney injury in neonates: A retrospective study
Pediatric Nephrology
Alabbas, A. and Campbell, A. and Skippen, P. and Human, D. and Matsell, D. and Mammen, C.
DOI: 10.1007/s00467-013-2454-3
2013

The importance of clinical pathways and protocols in pediatric nephrology
Pediatric Nephrology
Mammen, C. and Matsell, D.G. and Lemley, K.V.
DOI: 10.1007/s00467-013-2577-6
2013

A rare cause of hypertension in a healthy 2-year-old female: Answers
Pediatric Nephrology
Fox, D.A. and Matsell, D.G. and Hursh, B.E. and Mammen, C.
DOI: 10.1007/s00467-012-2164-2
2012

Urinary biomarkers in obstructive nephropathy
Clinical Journal of the American Society of Nephrology
Trnka, P. and Ivanova, L. and Hiatt, M.J. and Matsell, D.G.
DOI: 10.2215/CJN.09640911
2012

A rare cause of hypertension in a healthy 2-year-old female: Questions
Pediatric Nephrology
Fox, D.A. and Matsell, D.G. and Hursh, B.E. and Mammen, C.
DOI: 10.1007/s00467-012-2161-5
2012

Congenital urinary tract obstruction: Defining markers of developmental kidney injury
Pediatric Research
Trnka, P. and Hiatt, M.J. and Tarantal, A.F. and Matsell, D.G.
DOI: 10.1038/pr.2012.113
2012

Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: A prospective cohort study
American Journal of Kidney Diseases
Mammen, C. and Al Abbas, A. and Skippen, P. and Nadel, H. and Levine, D. and Collet, J.P. and Matsell, D.G.
DOI: 10.1053/j.ajkd.2011.10.048
2012

Nephrotic syndrome developing during induction chemotherapy for childhood acute lymphoblastic leukemia
Clinical and Experimental Nephrology
Prestidge, C. and Rassekh, S.R. and Matsell, D.G.
DOI: 10.1007/s10157-010-0401-1
2011

Ontogeny of CD24 in the human kidney
Kidney International
Ivanova, L. and Hiatt, M.J. and Yoder, M.C. and Tarantal, A.F. and Matsell, D.G.
DOI: 10.1038/ki.2010.39
2010

The authors reply
Kidney International
Matsell, D.G. and Ivanova, L.
DOI: 10.1038/ki.2010.244
2010

Remodeling of the fetal collecting duct epithelium
American Journal of Pathology
Hiatt, M.J. and Ivanova, L. and Toran, N. and Tarantal, A.F. and Matsell, D.G.
DOI: 10.2353/ajpath.2010.090389
2010

Phenotypic transition of the collecting duct epithelium in congenital urinary tract obstruction
Journal of Biomedicine and Biotechnology
Trnka, P. and Hiatt, M.J. and Ivanova, L. and Tarantal, A.F. and Matsell, D.G.
DOI: 10.1155/2010/696034
2010

An outbreak of diarrhea-associated childhood hemolytic uremic syndrome: the Walkerton epidemic.
Kidney international. Supplement
Matsell, D.G. and White, C.T.
2009

Characterization and culture of fetal rhesus monkey renal cortical cells
Pediatric Research
Leapley, A.C. and Lee, C.C.I. and Batchelder, C.A. and Yoder, M.C. and Matsell, D.G. and Tarantal, A.F.
DOI: 10.1203/PDR.0b013e3181b45565
2009

Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors
Differentiation
Batchelder, C.A. and Lee, C.C.I. and Matsell, D.G. and Yoder, M.C. and Tarantal, A.F.
DOI: 10.1016/j.diff.2009.05.001
2009

An outbreak of diarrhea-associated childhood hemolytic uremic syndrome: The Walkerton epidemic
Kidney International
Matsell, D.G. and White, C.T.
DOI: 10.1038/ki.2008.628
2009

Outcome of kidney transplantation in Canadian Aboriginal children in the province of British Columbia
Pediatric Transplantation
Matsuda-Abedini, M. and Al-Alsheikh, K. and Hurley, R.M. and Matsell, D.G. and Chow, J. and Carter, J.E. and Lirenman, D.S.
DOI: 10.1111/j.1399-3046.2008.01074.x
2009

The role of the type I insulin-like growth factor receptor (IGF-IR) in glomerular integrity
Growth Hormone and IGF Research
Bridgewater, D.J. and Dionne, J.M. and Butt, M.J. and Pin, C.L. and Matsell, D.G.
DOI: 10.1016/j.ghir.2007.06.003
2008

Mesenchymal transition in kidney collecting duct epithelial cells
American Journal of Physiology - Renal Physiology
Ivanova, L. and Butt, M.J. and Matsell, D.G.
DOI: 10.1152/ajprenal.00326.2007
2008

Albuminuria and Estimated GFR 5 Years After Escherichia coli O157 Hemolytic Uremic Syndrome: An Update
American Journal of Kidney Diseases
Garg, A.X. and Salvadori, M. and Okell, J.M. and Thiessen-Philbrook, H.R. and Suri, R.S. and Filler, G. and Moist, L. and Matsell, D. and Clark, W.F.
DOI: 10.1053/j.ajkd.2007.10.042
2008

Quiz page. Acute rheumatic fever with concomitant poststreptococcal glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Sinha, R. and Al-AlSheikh, K. and Prendiville, J. and Magil, A. and Matsell, D.
DOI: 10.1053/j.ajkd.2007.04.001
2007

Selected primary care issues and comorbidities in children who are on maintenance dialysis: A review for the pediatric nephrologist
Clinical Journal of the American Society of Nephrology
White, C.T. and Trnka, P. and Matsell, D.G.
DOI: 10.2215/CJN.04021206
2007

Collecting duct epithelial-mesenchymal transition in fetal urinary tract obstruction
Kidney International
Butt, M.J. and Tarantal, A.F. and Jimenez, D.F. and Matsell, D.G.
DOI: 10.1038/sj.ki.5002457
2007

Absence of renal sequelae after childhood Escherichia coli O157:H7 gastroenteritis
Kidney International
Garg, A.X. and Clark, W.F. and Salvadori, M. and Thiessen-Philbrook, H.R. and Matsell, D.
DOI: 10.1038/sj.ki.5001645
2006

A gradient of acute gastroenteritis was characterized, to assess risk of long-term health sequelae after drinking bacterial-contaminated water
Journal of Clinical Epidemiology
Garg, A.X. and Marshall, J. and Salvadori, M. and Thiessen-Philbrook, H.R. and Macnab, J. and Suri, R.S. and Haynes, R.B. and Pope, J. and Clark, W. and Collins, S. and Howard, J. and Mahon, J. and Matsell, D. and Moist, L. and Ray, J. and Rosas-Arellano, P.
DOI: 10.1016/j.jclinepi.2005.08.014
2006

Long-term health sequelae following E.coli and Campylobacter contamination of municipal water: Population sampling and assessing non-participation biases
Canadian Journal of Public Health
Garg, A.X. and Macnab, J. and Clark, W. and Ray, J.G. and Marshall, J.K. and Suri, R.S. and Devereaux, P.J. and Haynes, B. and Collins, S. and Howard, J. and Mahon, J. and Matsell, D. and Moist, L. and Pope, J. and Rosos-Avellano, P. and Salvadori, M.
2005

Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway
Kidney International
Bridgewater, D.J. and Ho, J. and Sauro, V. and Matsell, D.G.
DOI: 10.1111/j.1523-1755.2005.00208.x
2005

Microalbuminuria three years after recovery from Escherichia coli O157 hemolytic uremic syndrome due to municipal water contamination
Kidney International
Garg, A.X. and Clark, W.F. and Salvadori, M. and Macnab, J. and Suri, R.S. and Haynes, R.B. and Matsell, D.
DOI: 10.1111/j.1523-1755.2005.00225.x
2005

Renal leiomyoma associated with Epstein-Barr virus in a pediatric transplant patient
American Journal of Kidney Diseases
Dionne, J.M. and Carter, J.E. and Matsell, D. and MacNeily, A.E. and Morrison, K.B. and De Sa, D.
DOI: 10.1053/j.ajkd.2005.04.028
2005

Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking water
CMAJ
Garg, A.X. and Moist, L. and Matsell, D. and Thiessen-Philbrook, H.R. and Haynes, R.B. and Suri, R.S. and Salvador, M. and Ray, J. and Clark, W.F.
DOI: 10.1503/cmaj.050581
2005

Cytochrome P450 3A and 2B6 in the developing kidney: Implications for ifosfamide nephrotoxicity
Pediatric Nephrology
Aleksa, K. and Matsell, D. and Krausz, K. and Gelboin, H. and Ito, S. and Koren, G.
DOI: 10.1007/s00467-004-1807-3
2005

Neonatal renal venous thrombosis: Clinical outcomes and prevalence of prothrombotic disorders
Journal of Pediatrics
Marks, S.D. and Massicotte, M.P. and Steele, B.T. and Matsell, D.G. and Filler, G. and Shah, P.S. and Perlman, M. and Rosenblum, N.D. and Shah, V.S.
DOI: 10.1016/j.jpeds.2005.02.022
2005

Antiproteinuric effects of enlapril and losartan: A pilot study
Pediatric Nephrology
White, C.T. and Macpherson, C.F. and Hurley, R.M. and Matsell, D.G.
DOI: 10.1007/s00467-003-1190-5
2003

Increased expression of insulin-like growth factors in progressive glomerulonephritis of the MRL/lpr mouse
Lupus
Mohammed, J.A. and Mok, A.Y.P. and Parbtani, A. and Matsell, D.G.
DOI: 10.1191/0961203303lu422oa
2003

Long-term Renal Prognosis of Diarrhea-Associated Hemolytic Uremic Syndrome: A Systematic Review, Meta-analysis, and Meta-regression
Journal of the American Medical Association
Garg, A.X. and Suri, R.S. and Barrowman, N. and Rehman, F. and Matsell, D. and Rosas-Arellano, M.P. and Salvadori, M. and Haynes, R.B. and Clark, W.F.
DOI: 10.1001/jama.290.10.1360
2003

Insulin-like growth factor binding protein-2 modulates podocyte mitogenesis
Pediatric Nephrology
Bridgewater, D.J. and Matsell, D.G.
DOI: 10.1007/s00467-003-1242-x
2003

Experimental models of fetal obstructive nephropathy
Pediatric Nephrology
Matsell, D.G. and Tarantal, A.F.
DOI: 10.1007/s00467-002-0910-6
2002

Altered primate glomerular development due to in utero urinary tract obstruction
Kidney International
Matsell, D.G. and Mok, A. and Tarantal, A.F.
DOI: 10.1046/j.1523-1755.2002.00274.x
2002

A G339R mutation in the CTNS gene is a common cause of nephropathic cystinosis in the south western Ontario Amish Mennonite population [2]
Journal of Medical Genetics
Rupar, C.A. and Matsell, D. and Surry, S. and Siu, V.
2001

Fetal rhesus monkey model of obstructive renal dysplasia
Kidney International
Tarantal, A.F. and Han, V.K.M. and Cochrum, K.C. and Mok, A. and Dasilva, M. and Matsell, D.G.
DOI: 10.1046/j.1523-1755.2001.059002446.x
2001

Children's UTIs in the new millennium: Diagnosis, investigation, and treatment of childhood urinary tract infections in the year 2001
Canadian Family Physician
White, C.T. and Matsell, D.G.
2001

Expression of complement regulatory proteins in the developing human kidney
Pediatric Nephrology
Bridgewater, D.J.V. and Mok, A. and Matsell, D.G.
DOI: 10.1007/s004670000390
2000

Evaluation of metanephric maturation in a human fetal kidney explant model
In Vitro Cellular and Developmental Biology - Animal
Matsell, D.G.
DOI: 10.1007/s11626-998-0096-8
1998

Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: Results of a Canadian collaboratlve study
Journal of Pediatrics
Rowe, P.C. and Orrbine, E. and Lior, H. and Wells, G.A. and Yetisir, E. and Clulow, M. and McLaine, P.N. and Carter, J. and Lirenman, D. and Anderson, J. and Robson, L. and Trevenen, C. and Cadrain, G. and Miller-Hughes, D. and Henning, N. and Anand, C. and Gordon, R. and Cumming, J. and Harley, F. and Kibsey, P. and Rennie, R. and Pearce, P. and McClellan, D. and Hasinoff, D. and Albritton, W.L. and Richter, M. and Tabor, H. and Lovgren, M. and Kasian, G. and Scott, S. and Andreychuk, B. and Bingham, M. and Currie, L. and Homes, B. and Thomas, E. and McNaughton, M. and Ogborn, M. and Grimm, P. and Hoaban, D. and Walker, R. and Sareen, S. and Hammond, G. and Williams, T. and Winther, W. and Clark, W. and Lannigan, R. and Manarin, K. and Parbtani, A. and Hurley, R.M. and Matsell, D.G. and Devuono, T. and Loft, J. and Fase, J. and Reid, A. and Steele, B. and Smaill, F. and Jones, C. and Jones, L.F. and Karmali, M. and Balfe, J.W. and Eddy, A. and Geary, D. and Harvey, E. and Hebert, D. and Skorecki, K. and Winkler, M. and Lapp, V. and Cox, S. and Alexander, D. and Delisle, G. and Toffelmire, E. and Tomalty, L. and Kilbred, B. and Morrin, P. and Singer, M. and Peterson, Y. and Chan, F. and Wolfish, N. and MacKenzie, A. and Fuite, L. and Hyde, L. and Ng, B. and DeJesus, C. and Le Saux, N. and Stewart, M. and Ellis, E. and Goodver, K. and Trifiro, S. and Drummond, K. and Bell, L. and Laforte, D. and O{'}Reagan, S. and Robitaille, P. and Mongeau, J.-G. and Clermont M.-, J. and Letourneau, J. and Douville, G. and Brown, M. and Cote, L.
DOI: 10.1016/S0022-3476(98)70303-8
1998

Renal dysplasia: New approaches to an old problem
American Journal of Kidney Diseases
Matsell, D.G.
DOI: 10.1016/S0272-6386(98)70014-9
1998

Regulation of the taurine transporter gene in the S3 segment of the proximal tubule
Kidney International
Matsell, D.G. and Bennett, T. and Han, X. and Budreau, A.M. and Chesney, R.W.
DOI: 10.1038/ki.1997.391
1997

Insulin-like growth factor (IGF) and IGF binding protein gene expression in multicystic renal dysplasia
Journal of the American Society of Nephrology
Matsell, D.G. and Bennett, T. and Armstrong, R.A. and Goodyer, P. and Goodyer, C. and Han, V.K.M.
1997

Characterization of fetal ovine renal dysplasia after mid-gestation ureteral obstruction
Clinical and Investigative Medicine
Matsell, D.G. and Bennett, T. and Bocking, A.D.
1996

IGF-binding protein mrnas in the human fetus: Tissue and cellular distribution of developmental expression
Human Heredity
Han, V.K.M. and Matsell, D.G. and Delhanty, P.J.D. and Hill, D.J. and Shimasaki, S. and Nygard, K.
DOI: 10.1159/000184780
1996

The pathogenesis of multicystic dysplastic kidney disease: Insights from the study of fetal kidneys
Laboratory Investigation
Matsell, D.G. and Bennett, T. and Goodyer, P. and Goodyer, C. and Han, V.K.M.
1996

Escherichia coli verotoxin binding to human paediatric glomerular mesangial cells
Pediatric Nephrology
Robinson, L.A. and Hurley, R.M. and Lingwood, C. and Matsell, D.G.
DOI: 10.1007/BF00868715
1995

Cytokine stimulation of prostaglandin production inhibits the proliferation of serum-stimulated mesangial cells
Kidney International
Matsell, D.G. and Gaber, L.W. and Malik, K.U.
DOI: 10.1038/ki.1994.19
1994

Terminal complement complexes in acute poststreptococcal glomerulonephritis
Pediatric Nephrology
Matsell, D.G. and Wyatt, R.J. and Gaber, L.W.
DOI: 10.1007/BF00869086
1994

Clinical quiz
Pediatric Nephrology
White, C.T. and Matsell, D.G. and Hurley, R.M.
DOI: 10.1007/BF00869124
1994

Febrile infants at low risk for serious bacterial infection - An appraisal of the Rochester criteria and implications for management
Pediatrics
Jaskiewicz, J.A. and McCarthy, C.A. and Richardson, A.C. and White, K.C. and Fisher, D.J. and Dagan, R. and Powell, K.R. and Korones, D.N. and Bracikowski, A. and Deveikis, A. and Stutman, H. and Lohr, J.A. and Carlson, D.W. and Kennedy, R.M. and Beach, P.S. and Krause, P.J. and Gudnason, T. and Li, M. and Matsell, D.
1994

Expression of insulin-like growth factor and binding protein genes during nephrogenesis
Kidney International
Matsell, D.G. and Delhanty, P.J.D. and Stepaniuk, O. and Goodyer, C. and Han, V.K.M.
DOI: 10.1038/ki.1994.364
1994

The role of I and B in peritonitis associated with the nephrotic syndrome of childhood
Pediatric Research
Matsell, D.G. and Wyatt, R.J.
1993

Interleukin 1 and interleukin 6 inhibition of mesangial cell proliferation: Role of PGE2
Journal of Lipid Mediators
Matsell, D.G. and Gaber, L.W. and Sehic, E. and Malik, K.U.
1992

Arteriovenous fistula after biopsy of renal transplant kidney: diagnosis and treatment
Pediatric Nephrology
Matsell, D.G. and Jones, D.P. and Boulden, T.F. and Burton, E.M. and Baum, S.L. and Tonkin, I.L.D.
DOI: 10.1007/BF00866508
1992

Plasma Terminal Complement Complexes in Acute Poststreptococcal Glomerulonephritis
American Journal of Kidney Diseases
Matsell, D.G. and Roy, S. and Tamerius, J.D. and Morrow, P.R. and Kolb, W.P. and Wyatt, R.J.
DOI: 10.1016/S0272-6386(12)80480-X
1991

Reliability and validity of the objective structured clinical examination in paediatrics
Medical Education
MATSELL, D.G. and WOLFISH, N.M. and HSU, E.
DOI: 10.1111/j.1365-2923.1991.tb00069.x
1991

Acute poststreptococcal glomerulonephritis and acute rheumatic fever: Occurrence in the same patient
Child Nephrology and Urology
Matsell, D.G. and Baldree, L.A. and DiSessa, T.G. and Gaber, L.S. and Stapleton, F.B.
1990

Isolated Angiitis of the Central Nervous System in Childhood
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Matsell, D.G. and Keene, D.L. and Jimenez, C. and Humphreys, P.
DOI: 10.1017/S0317167100030377
1990

Nephrosis, peritonitis and complement deficiency
Pediatric Nephrology
Matsell, D.G. and Roy III, S. and Bin, J. and Wyatt, R.J.
DOI: 10.1007/BF00869845
1990

Short of the mark: Paediatric Data Interpretation.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Matsell D
06/1988

Research
Research Group Members

Pratichi Kadam, Research Staff