- Overview
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My focus is on doing more with less. If we need to take blood from a child, then take as little as possible. If we need to take a biopsy, can we get both diagnosis and a treatment plan all at once? Combining what we know from many years of research with what we want (accurate diagnosis, treatment options) helps personalize drug treatment regimens and minimize blood collections, all while improving the overall patient experience and providing better outcomes. By working with cutting edge technologies and utilizing the extensive expertise of physicians, pathologists and scientists, we can drive substantial improvement in patient health and wellbeing.
- Publications
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Targeted proteomic approach for quantification of collagen type I and type III in formalin-fixed paraffin-embedded tissue
Scientific Reports
Nicole L. Rosin and Tara M. L. Winstone and Margaret Kelley and Jeff Biernaskie and Antoine Dufour and Dennis J. Orton
DOI: 10.1038/s41598-024-68377-9
08/2024Understanding Elevated Vitamin D Measurements to Uncover Hypercalcemia Etiology
Clinical Chemistry
DOI: 10.1093/clinchem/hvae044
2024Increased Lp(a) Workload Volumes Reflect Uptake of the 2021 Canadian Cardiovascular Society Guidelines for Management of Dyslipidemia
Canadian Journal of Cardiology
DOI: 10.1016/j.cjca.2024.02.019
2024Agreement of LC-MS assays for IGF-1 traceable to NIST and WHO standards permits harmonization of reference intervals between laboratories
Clinical Biochemistry
DOI: 10.1016/j.clinbiochem.2023.04.002
2023Distribution of videos demonstrating best practices in preventing hemolysis is associated with reduced hemolysis among nurse-collected specimens in hospitals
Clinical Biochemistry
DOI: 10.1016/j.clinbiochem.2023.110632
2023Biological variation in clozapine and metabolite reporting during therapeutic drug monitoring
Clinica Chimica Acta
DOI: 10.1016/j.cca.2022.04.005
2022Exosomal proteomic analysis reveals changes in the urinary proteome of rats with unilateral ureteral obstruction
Canadian Journal of Chemistry
DOI: 10.1139/cjc-2017-0681
2018Bone metabolism
Endocrine Biomarkers: Clinicians and Clinical Chemists in Partnership
DOI: 10.1016/B978-0-12-803412-5.00004-5
2017Novel approach to establishing an aldosterone: Renin ratio cutoff for primary aldosteronism
Hypertension
DOI: 10.1161/HYPERTENSIONAHA.116.08407
2017One-step extraction and quantitation of toxic alcohols and ethylene glycol in plasma by capillary gas chromatography (GC) with flame ionization detection (FID)
Clinical Biochemistry
DOI: 10.1016/j.clinbiochem.2015.09.007
2016Fasting time and vitamin B12 levels in a community-based population
Clinica Chimica Acta
DOI: 10.1016/j.cca.2016.05.005
2016Critically high plasma ammonia in an adolescent girl
Clinical Chemistry
DOI: 10.1373/clinchem.2016.259473
2016Resolubilization of precipitated intact membrane proteins with cold formic acid for analysis by mass spectrometry
Journal of Proteome Research
DOI: 10.1021/pr500864a
2014Reprint of "GELFrEE fractionation combined with mass spectrometry for proteome analysis of secreted toxins from Enteropathogenic Escherichia coli (EPEC)"
Molecular and Cellular Probes
DOI: 10.1016/j.mcp.2014.01.004
2014Proteomic analysis of rat proximal tubule cells following stretch-induced apoptosis in an in vitro model of kidney obstruction
Journal of Proteomics
DOI: 10.1016/j.jprot.2013.11.025
2014Dual LC-MS platform for high-throughput proteome analysis
Journal of Proteome Research
DOI: 10.1021/pr400738a
2013GELFrEE fractionation combined with mass spectrometry for proteome analysis of secreted toxins from Enteropathogenic Escherichia coli (EPEC)
Molecular and Cellular Probes
DOI: 10.1016/j.mcp.2013.06.004
2013Proteomic workflows for biomarker identification using mass spectrometry - Technical and statistical considerations during initial discovery
Proteomes
DOI: 10.3390/proteomes1020109
2013A universal, high recovery assay for protein quantitation through temperature programmed liquid chromatography (TPLC)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
DOI: 10.1016/j.jchromb.2013.01.021
2013The htpAB operon of Legionella pneumophila cannot be deleted in the presence of the groE chaperonin operon of Escherichia coli
Canadian Journal of Microbiology
DOI: 10.1139/w11-086
2011 - Research
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Targeted proteomic approach for quantification of collagen subtypes in formalin-fixed paraffin-embedded tissue
This project was established to quantify specific proteins in FFPE tissue. Here we develop our understanding of extracellular matrix protein composition during wound healing and fibrosis. The project was a proof-of-principle application to build targeted protein quantitation methods from FFPE tissues and may be applied to a variety of targets.Development and evaluation of a NUDT15 phenotyping assay in blood
NUDT15 is an enzyme in the metabolism of thiopurine medications that when deficient, causes significant adverse drug reactions to these medications. Primarily occurring in Asian populations, there are no current methods available to phenotype this enzyme and genotyping is often limited to analyzing a single polymorphism while dozens have been described.Development of a screening method to predict adverse outcomes in 5-FU chemotherapy
5-Fluorouracil is a chemotherapeutic drug with significant associated toxicity. Similar to the above NUDT15 polymorphism, this project was developed to help predict which patients, if any, may experience toxicity associated with a metabolic enzyme deficiency (DPYD).GrantsIGF-1 in Treatment of Growth Hormone Deficiency. Funding Source: Pfizer Long-Acting Growth Hormone Research
Crafting beating heart cells to deliver personalized treatments for kids with hypertrophic cardiomyopathy
Researchers at BC Children's Hospital Research Institute are working with human-induced pluripotent stem cells to develop safer and more effective treatments for kids with hypertrophic cardiomyopathy.
