Overview

I am one of the original founders of the Vaccine Evaluation Center, a leading centre for applied vaccine research in Canada. Six researchers contribute to the VEC’s core research program, including S. Dobson, T. Kollmann, L. Sauvé, J. Bettinger, S.Gantt, and several more collaborate from other local institutions (BCCDC, VCHA). The researchers share a field team (coordinators, nurses, assistants), data management group (manager, statistician, assistants) and specialized laboratory. The main research themes involve disease burden studies, vaccine clinical trials, and studies to fine tune public immunization programs, including ongoing assessment of vaccine safety. The Vaccine Center researchers collaborate with vaccine specialists across the country and with provincial and federal health officials, with the goal of efficiently translating new vaccine products into optimal vaccination programs for children and adults.

Publications

Fever prophylaxis can reduce vaccine responses: A caution
Paediatrics & Child Health
David Scheifele, Brian Ward
DOI: 10.1093/pch/pxy011
03/2018

Cellular immune responses of older adults to four influenza vaccines: Results of a randomized, controlled comparison.
Human vaccines & immunotherapeutics
DOI: 10.1080/21645515.2017.1337615
PubMed: 28635557
09/2017

Adverse events following live-attenuated intranasal influenza vaccination of children with cystic fibrosis: Results from two influenza seasons.
Vaccine
DOI: 10.1016/j.vaccine.2017.07.068
PubMed: 28774563
09/2017

Maternal immunisation: collaborating with mother nature.
The Lancet. Infectious diseases
DOI: 10.1016/s1473-3099(17)30229-3
PubMed: 28433705
07/2017

Pertussis and influenza immunisation during pregnancy: a landscape review
The Lancet Infectious Diseases
Bahaa Abu Raya, Kathryn M Edwards, David W Scheifele, Scott A Halperin
DOI: 10.1016/s1473-3099(17)30190-1
07/2017

Viral interference and the live-attenuated intranasal influenza vaccine: Results from a pediatric cohort with cystic fibrosis.
Human vaccines & immunotherapeutics
DOI: 10.1080/21645515.2017.1287641
PubMed: 28273006
06/2017

Will Infant Hepatitis B Vaccination Protect Into Adulthood?: Extended Canadian Experience After a 2-, 4- and 6-month Immunization Schedule.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0000000000001543
PubMed: 28134742
06/2017

Do Dose Numbers Matter?: Evaluation of Differing Infant and Toddler Meningococcal C Conjugate Vaccine Programs in Canadian Children.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0000000000001278
PubMed: 27753770
11/2016

Influenza Virus Detection Following Administration of Live-Attenuated Intranasal Influenza Vaccine in Children With Cystic Fibrosis and Their Healthy Siblings.
Open forum infectious diseases
DOI: 10.1093/ofid/ofw187
PubMed: 27747255
10/2016

Hospitalization for Influenza A Versus B.
Pediatrics
DOI: 10.1542/peds.2015-4643
PubMed: 27535144
09/2016

Immunogenicity and safety of 3-dose primary vaccination with combined DTPa-HBV-IPV/Hib vaccine in Canadian Aboriginal and non-Aboriginal infants.
Vaccine
DOI: 10.1016/j.vaccine.2015.02.015
PubMed: 25701314
04/2015

Outcomes of invasive meningococcal disease in adults and children in Canada between 2002 and 2011: a prospective cohort study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
DOI: 10.1093/cid/civ028
PubMed: 25605282
04/2015

AMMI Canada 2015 Annual Conference: Abstracts: April 16 – 18, 2015 • Charlottetown, Prince Edward Island.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
2015

A randomized study to evaluate the immunogenicity and safety of a heptavalent diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, haemophilus influenzae b, and meningococcal serogroup C combination vaccine administered to infants at 2, 4 and 12 months of age.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0000000000000468
PubMed: 25037033
12/2014

The impact of the meningococcal serogroup C conjugate vaccine in Canada between 2002 and 2012.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
DOI: 10.1093/cid/ciu597
PubMed: 25069868
11/2014

Discussing the need for an adolescent hepatitis B vaccine booster in infant vaccinees
Paediatrics & Child Health
Michelle Pinto, David Scheifele
DOI: 10.1093/pch/19.8.404
10/2014

Trends in asymptomatic nasopharyngeal colonization with streptococcus pneumoniae after introduction of the 13-valent pneumococcal conjugate vaccine in Calgary, Canada.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0000000000000267
PubMed: 24463806
07/2014

Burden of seasonal influenza in children with neurodevelopmental conditions.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0000000000000272
PubMed: 24918745
07/2014

High Level Antibody Avidity is Achieved in HIV-Seropositive Recipients of an Inactivated Split Adjuvanted (AS03A) Influenza Vaccine
Journal of Clinical Immunology
Karen K. Yam, Erica Gipson, Marina Klein, Sharon Walmsley, David Haase, Scott Halperin, David Scheifele, Brian J. Ward, Curtis Cooper
DOI: 10.1007/s10875-014-0054-z
05/2014

Childhood immunization rates in Canada are too low: UNICEF
Paediatrics & Child Health
David W Scheifele, Scott A Halperin, Julie A Bettinger
DOI: 10.1093/pch/19.5.237
05/2014

Immunization delivery in British Columbia: perspectives of primary care physicians.
Canadian family physician Medecin de famille canadien
PubMed: 24627403
03/2014

Approved but non-funded vaccines: Accessing individual protection
Vaccine
David W. Scheifele, Brian J. Ward, Scott A. Halperin, Shelly A. McNeil, Natasha S. Crowcroft, Gordean Bjornson
DOI: 10.1016/j.vaccine.2013.12.027
02/2014

Knowledge, attitudes, beliefs and behaviours of older adults about pneumococcal immunization, a Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network (PCIRN) investigation.
BMC public health
DOI: 10.1186/1471-2458-14-442
PubMed: 24884433
2014

Diversity of Canadian meningococcal serogroup B isolates and estimated coverage by an investigational meningococcal serogroup B vaccine (4CMenB).
Vaccine
DOI: 10.1016/j.vaccine.2013.03.063
PubMed: 23588089
12/2013

Applicability of the Brighton Collaboration Case Definition for seizure after immunization in active and passive surveillance in Canada.
Vaccine
DOI: 10.1016/j.vaccine.2013.09.048
PubMed: 24099871
11/2013

Safety, immunogenicity, and tolerability of three influenza vaccines in older adults: results of a randomized, controlled comparison.
Human vaccines & immunotherapeutics
DOI: 10.4161/hv.25580
PubMed: 23839537
11/2013

Elevated inflammatory mediators in adults with oculorespiratory syndrome following influenza immunization: a public health agency of Canada/Canadian Institutes of Health Research Influenza Research Network Study.
Clinical and vaccine immunology : CVI
DOI: 10.1128/cvi.00659-12
PubMed: 23697573
08/2013

Response to the changing epidemiology of meningococcal disease in North America 1945-2010.
Human vaccines & immunotherapeutics
DOI: 10.4161/hv.24009
PubMed: 23454840
06/2013

Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial.
JAMA
DOI: 10.1001/jama.2013.1625
PubMed: 23632723
05/2013

Controlling serogroup B invasive meningococcal disease: the Canadian perspective.
Expert review of vaccines
DOI: 10.1586/erv.13.30
PubMed: 23659299
05/2013

Unusual patterns of IgG avidity in some young children following two doses of the adjuvanted pandemic H1N1 (2009) influenza virus vaccine.
Clinical and vaccine immunology : CVI
DOI: 10.1128/cvi.00619-12
PubMed: 23345582
04/2013

The disease burden of invasive meningococcal serogroup B disease in Canada.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e3182706b89
PubMed: 22926207
01/2013

Safety and immunogenicity of 2010–2011 A/H1N1pdm09-containing trivalent inactivated influenza vaccine in adults previously given AS03-adjuvanted H1N1 2009 pandemic vaccine: results of a randomized trial.
Human vaccines & immunotherapeutics
DOI: 10.4161/hv.22619
PubMed: 23570051
01/2013

How best to describe the risk of meningococcal B infection?
Paediatrics & Child Health
Manish Sadarangani, Julie A Bettinger, David W Scheifele
DOI: 10.1093/pch/18.10.543
2013

Cross-reactive and vaccine-induced antibody to an emerging swine-origin variant of influenza A virus subtype H3N2 (H3N2v).
The Journal of infectious diseases
DOI: 10.1093/infdis/jis500
PubMed: 22872731
12/2012

Comparison of children hospitalized with seasonal versus pandemic influenza A, 2004-2009.
Pediatrics
DOI: 10.1542/peds.2011-3216
PubMed: 22931901
09/2012

The effect of funded varicella immunization programs on varicella-related hospitalizations in IMPACT centers, Canada, 2000-2008.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e318260cc4d
PubMed: 22647896
09/2012

Compatibility of ASO3-adjuvanted H1N1pdm09 and seasonal trivalent influenza vaccines in adults: results of a randomized, controlled trial.
Vaccine
DOI: 10.1016/j.vaccine.2012.05.029
PubMed: 22652402
07/2012

Evaluation of meningococcal serogroup C conjugate vaccine programs in Canadian children: interim analysis.
Vaccine
DOI: 10.1016/j.vaccine.2012.04.034
PubMed: 22537988
06/2012

Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: a PHAC/CIHR Influenza Research Network (PCIRN) study.
Vaccine
DOI: 10.1016/j.vaccine.2012.03.046
PubMed: 22469860
05/2012

Immunogenicity of a half-dose of adjuvanted 2009 pandemic H1N1 influenza vaccine in adults: a prospective cohort study.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
DOI: 10.1007/s10096-011-1352-5
PubMed: 21796343
04/2012

High-Level Immunogenicity Is Achieved Vaccine With Adjuvanted Pandemic H1N1 and Improved With Booster Dosing in a Randomized Trial of HIV-Infected Adults
HIV Clinical Trials
Curtis Cooper, Marina Klein, Sharon Walmsley, David Haase, Donna MacKinnon-Cameron, Kimberley Marty, Yan Li, Bruce Smith, Scott Halperin, Barb Law, David Scheifele
DOI: 10.1310/hct1301-023
01/2012

Immune responses in adults to revaccination with a tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine 10 years after a previous dose.
Vaccine
DOI: 10.1016/j.vaccine.2011.11.035
PubMed: 22115634
01/2012

Safety and immunogenicity of a 13-valent pneumococcal conjugate vaccine in healthy infants and toddlers given with routine pediatric vaccinations in Canada.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e318233049d
PubMed: 21960186
01/2012

Cost effectiveness of infant vaccination for rotavirus in Canada.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
DOI: 10.1155/2012/327054
PubMed: 23730312
2012

Strategies for successful rapid trials of influenza vaccine.
Clinical trials (London, England)
DOI: 10.1177/1740774511419868
PubMed: 21900340
12/2011

Can children with minor illnesses be safely immunized?
Paediatrics & Child Health
Keswadee Lapphra, David Scheifele
DOI: 10.1093/pch/16.8.463
10/2011

The responses of Aboriginal Canadians to adjuvanted pandemic (H1N1) 2009 influenza vaccine.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
DOI: 10.1503/cmaj.110196
PubMed: 21788422
09/2011

Randomized controlled trial of dose response to influenza vaccine in children aged 6 to 23 months.
Pediatrics
DOI: 10.1542/peds.2010-2777
PubMed: 21768314
08/2011

Evaluation of adjuvanted pandemic H1N1(2009) influenza vaccine after one and two doses in young children.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e3182068f33
PubMed: 21178654
05/2011

Severe genital ulceration in an acute epstein-barr virus infection.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e3181f41b2e
PubMed: 20736877
02/2011

Adverse neurologic reactions after both doses of pandemic H1N1 influenza vaccine with optic neuritis and demyelination.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e3181f11126
PubMed: 20686434
01/2011

Optimizing Canadian public immunization programs: a prescription for action.
Canadian journal of public health = Revue canadienne de sante publique
PubMed: 21714317
2011

Heterogeneity of rotavirus testing and admitting practices for gastroenteritis among 12 tertiary care pediatric hospitals: Implications for surveillance.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
DOI: 10.1155/2011/656404
PubMed: 22379483
2011

Cortisol, behavior, and heart rate reactivity to immunization pain at 4 months corrected age in infants born very preterm.
The Clinical journal of pain
DOI: 10.1097/ajp.0b013e3181e5bb00
PubMed: 20664338
10/2010

Substantial morbidity for hospitalized children with community-acquired rotavirus infections: 2005-2007 IMPACT surveillance in Canadian hospitals.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e3181e20c94
PubMed: 20467353
09/2010

A nationwide survey of past hepatitis A infections among Canadian adults
Vaccine
David W. Scheifele, Gaston De Serres, Vladimir Gilca, Bernard Duval, Ruth Milner, Margaret Ho, Jan J. Ochnio
DOI: 10.1016/j.vaccine.2010.05.076
07/2010

Regrettable lack of definition of the “well tolerated” vaccine
Vaccine
David Scheifele, Scott Halperin, Danuta Skowronski, James Kellner, Brian Ward, Ian Gemmill, Gaston De Serres
DOI: 10.1016/j.vaccine.2010.03.037
05/2010

Pandemic influenza in Canadian children: a summary of hospitalized pediatric cases.
Vaccine
DOI: 10.1016/j.vaccine.2010.02.044
PubMed: 20189488
04/2010

Postvaccination Thrombocytopenia in Canada
The Pediatric Infectious Disease Journal
Laura J. Sauvé, Julie Bettinger, David Scheifele, Scott Halperin, Wendy Vaudry, Barbara Law
DOI: 10.1097/inf.0b013e3181d2bb45
02/2010

The effect of routine vaccination on invasive pneumococcal infections in Canadian children, Immunization Monitoring Program, Active 2000–2007
Vaccine
Julie A. Bettinger, David W. Scheifele, James D. Kellner, Scott A. Halperin, Wendy Vaudry, Barbara Law, Gregory Tyrrell
DOI: 10.1016/j.vaccine.2009.12.026
02/2010

Cellular immunity as a potential cause of local reactions to booster vaccination with diphtheria and tetanus toxoids and acellular pertussis antigens.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e3181a9cc2a
PubMed: 19755930
11/2009

Does vaccination with the varicella vaccine within four weeks after the measles, mumps and rubella vaccine reduce protection?
Paediatrics & Child Health
Keswadee Lapphra, David Scheifele
DOI: 10.1093/pch/14.8.501
10/2009

Changing epidemiology of invasive pneumococcal disease in Canada, 1998-2007: update from the Calgary-area Streptococcus pneumoniae research (CASPER) study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
DOI: 10.1086/599827
PubMed: 19508165
07/2009

Pediatric combined formulation DTaP–IPV/Hib vaccine
Expert Review of Vaccines
Craig White, Scott A Halperin, David W Scheifele
DOI: 10.1586/erv.09.59
07/2009

Epidemiology of pertussis and Haemophilus influenzae type b disease in Canada with exclusive use of a diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b pediatric combination vaccine and an adolescent-adult tetanus-diphtheria-acellular pertussis vaccine: implications for disease prevention in the United States.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e318199d2fc
PubMed: 19436236
06/2009

Safety and immunogenicity of a measles-mumps-rubella-varicella vaccine given as a second dose in children up to six years of age.
Vaccine
DOI: 10.1016/j.vaccine.2009.02.044
PubMed: 19428882
05/2009

Vaccination site reaction or bacterial cellulitis?
Paediatrics & Child Health
Keswadee Lapphra, David Scheifele
DOI: 10.1093/pch/14.4.245
04/2009

The impact of childhood meningococcal serogroup C conjugate vaccine programs in Canada.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e31819040e7
PubMed: 19209096
03/2009

Do childhood vaccines cause thrombocytopenia?
Paediatrics & Child Health
Laura J Sauvé, David Scheifele
DOI: 10.1093/pch/14.1.31
01/2009

Profile of serogroup Y meningococcal infections in Canada: Implications for vaccine selection.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
PubMed: 21119789
2009

Children hospitalized with influenza during the 2006-2007 season: a report from the Canadian Immunization Monitoring Program, Active (IMPACT).
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 19368059
12/2008

Ongoing control of Haemophilus influenzae type B infections in Canadian children, 2004-2007.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e31816fc339
PubMed: 18594482
08/2008

Influenza vaccination in paediatric nurses: Cross-sectional study of coverage, refusal, and factors in acceptance
Vaccine
Seamus P. Norton, David W. Scheifele, Julie A. Bettinger, Robert M. West
DOI: 10.1016/j.vaccine.2008.03.033
06/2008

Effects of Routine Infant Vaccination With the 7-Valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Colonization With Streptococcus pneumoniae in Children in Calgary, Canada
The Pediatric Infectious Disease Journal
James D. Kellner, David Scheifele, Otto G. Vanderkooi, Judy MacDonald, Deirdre L. Church, Gregory J. Tyrrell
DOI: 10.1097/inf.0b013e3181658c5c
06/2008

The epidemiology of children hospitalized with herpes zoster in Canada: Immunization Monitoring Program, Active (IMPACT), 1991-2005.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e31815948b5
PubMed: 18174867
02/2008

How long can we expect pertussis protection to last after the adolescent booster dose of tetanus-diphtheria-pertussis (Tdap) vaccines?
Paediatrics & child health
PubMed: 19043506
12/2007

Invasive infections caused by haemophilus influenzae serotypes in twelve Canadian IMPACT centers, 1996-2001.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e31812f4f5b
PubMed: 17984810
11/2007

Erythema Nodosum, Mycobacterium avium Lymphadenitis, and a 15-mm Mantoux Test
The Pediatric Infectious Disease Journal
Heidi Budden, Rolando Ulloa-Gutierrez, Simon Dobson, David Scheifele
DOI: 10.1097/inf.0b013e31807a2fe1
08/2007

EFFECTIVENESS OF PNEUMOCOCCAL CONJUGATE VACCINE IN GREATER VANCOUVER, CANADA: 2004???2005
The Pediatric Infectious Disease Journal
Gordean Bjornson, David W. Scheifele, Julie Bettinger, David M. Patrick, Larry Gustafson, Patricia Daly, Gregory J. Tyrrell
DOI: 10.1097/inf.0b013e31803c56df
06/2007

Immunologic Considerations for the Timing of the Booster Dose of 7-Valent Pneumococcal Conjugate Vaccine in Young Children
The Pediatric Infectious Disease Journal
David W. Scheifele, Scott A. Halperin, Jan J. Ochnio, Michelle Mozel, Denzyl Duarte-Monteiro, David Wortzman
DOI: 10.1097/01.inf.0000259955.66171.0c
05/2007

The challenges facing Canadian trialists in an increasingly competitive global market: What can be done to remain competitive?
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
DOI: 10.1155/2007/635372
PubMed: 18923723
05/2007

Questions and answers on immunization
Paediatrics & Child Health
Susan Wootton, David Scheifele
DOI: 10.1093/pch/12.4.317
04/2007

Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection
Clinical Immunology
Aaron F. Hirschfeld, Julie A. Bettinger, Rachel E. Victor, Donald J. Davidson, Andrew J. Currie, J. Mark Ansermino, David W. Scheifele, Jordan S. Orange, Stuart E. Turvey
DOI: 10.1016/j.clim.2006.10.012
03/2007

The Effect of Changing From Whole-Cell to Acellular Pertussis Vaccine on the Epidemiology of Hospitalized Children With Pertussis in Canada
The Pediatric Infectious Disease Journal
Julie A. Bettinger, Scott A. Halperin, Gaston De Serres, David W. Scheifele, Theresa Tam
DOI: 10.1097/01.inf.0000247055.81541.04
01/2007

Participant-collected, mail-delivered oral fluid specimens can replace traditional serosurveys: a demonstration-of-feasibility survey of hepatitis A virus-specific antibodies in adults.
Canadian journal of public health = Revue canadienne de sante publique
PubMed: 17278676
2007

Invasive pneumococcal infections in Canadian children, 1998-2003: implications for new vaccination programs.
Canadian journal of public health = Revue canadienne de sante publique
PubMed: 17441533
2007

Surveillance for influenza admissions among children hospitalized in Canadian immunization monitoring program active centers, 2003-2004.
Pediatrics
DOI: 10.1542/peds.2005-2744
PubMed: 16950953
09/2006

Seven fatal varicella infections in children were potentially avoidable: A report from IMPACT centres from 2000 to 2005.
Paediatrics & child health
PubMed: 19030311
09/2006

Assessment of the compatibility of co-administered 7-valent pneumococcal conjugate, DTaP.IPV/PRP-T Hib and hepatitis B vaccines in infants 2-7 months of age.
Vaccine
DOI: 10.1016/j.vaccine.2005.11.021
PubMed: 16356598
03/2006

Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus.
The Journal of general virology
DOI: 10.1099/vir.0.81579-0
PubMed: 16476986
03/2006

Detection of Human Influenza Virus in the Stool of Children
The Pediatric Infectious Disease Journal
Susan H. Wootton, David W. Scheifele, Annie Mak, Martin Petric, Danuta M. Skowronski
DOI: 10.1097/01.inf.0000245097.95543.11
2006

Conforming to ICMJE principles.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
DOI: 10.1503/cmaj.1050172
PubMed: 16301708
11/2005

Progress in the prevention of pneumococcal infection.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
DOI: 10.1503/cmaj.051150
PubMed: 16275962
11/2005

Questions and answers on immunization
Paediatrics & Child Health
David Scheifele, Simon Dobson
DOI: 10.1093/pch/10.7.423
09/2005

Seroprevalence of hepatitis A infection in a low endemicity country: a systematic review
BMC Infectious Diseases
Ba' Pham, Bernard Duval, Gaston De Serres, Vladimir Gilca, Andrea C Tricco, Jan Ochnio, David W Scheifele
DOI: 10.1186/1471-2334-5-56
07/2005

Nationwide Canadian Study of Hepatitis A Antibody Prevalence Among Children Eight to Thirteen Years Old
The Pediatric Infectious Disease Journal
Bernard Duval, Gaston De Serres, Jan Ochnio, David Scheifele, Vladimir ??ilca
DOI: 10.1097/01.inf.0000164705.74498.86
06/2005

Serious Adverse Events Associated with Bacille Calmette-Gu??rin Vaccine in Canada
The Pediatric Infectious Disease Journal
Shelley L. Deeks, Michael Clark, David W. Scheifele, Barbara J. Law, Meenakshi Dawar, Nooshin Ahmadipour, Wikke Walop, C Edward Ellis, Arlene King
DOI: 10.1097/01.inf.0000164769.22033.2c
06/2005

Hepatitis A vaccines: the growing case for universal immunisation of children
Expert Opinion on Pharmacotherapy
David W Scheifele
DOI: 10.1517/14656566.6.2.157
02/2005

Oculorespiratory Syndrome After Influenza Immunization in Children
The Pediatric Infectious Disease Journal
Danuta M. Skowronski, Gordean Bjornson, Entesar Husain, Daniel L. Metzger, David W. Scheifele
DOI: 10.1097/01.inf.0000148924.89558.d5
01/2005

Invasive Haemophilus influenzae type b infections in vaccinated and unvaccinated children in Canada, 2001-2003.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
DOI: 10.1503/cmaj.1031861
PubMed: 15632405
01/2005

Canadian Association for Immunization Research and Evaluation (CAIRE) guidelines for industry-sponsored clinical trial and epidemiology contract research.
Human vaccines
DOI: 10.4161/hv.1.4.1971
PubMed: 17012864
2005

Safety and immunogenicity of a pentavalent combination vaccine (diphtheria, tetanus, acellular pertussis, polio, and haemophilus influenzae type B conjugate) when administered as a fourth dose at 15 to 18 months of age.
Human vaccines
DOI: 10.4161/hv.1.5.2079
PubMed: 17012882
2005

A Modified Vaccine Reduces the Rate of Large Injection Site Reactions to the Preschool Booster Dose of Diphtheria-Tetanus-Acellular Pertussis VaccineResults of a Randomized, Controlled Trial
The Pediatric Infectious Disease Journal
David W. Scheifele, Scott A. Halperin, Jan J. Ochnio, Alexander C. Ferguson, Danuta M. Skowronski
DOI: 10.1097/01.inf.0000190028.96152.46
2005

The Prevalence of Hepatitis A in Children in British Columbia
Canadian Journal of Infectious Diseases and Medical Microbiology
Jan J Ochnio, David W Scheifele, Murray Fyfe, Mark Bigham, David Bowering, Paul Martiquet, Margaret Ho, Douglas N Talling
DOI: 10.1155/2005/460983
2005

Practical questions and answers about childhood immunization
Paediatrics & Child Health
Reka Gustafson, David Scheifele
DOI: 10.1093/pch/9.7.476
09/2004

Using vaccine responses to plumb the immunologic consequences of tumor necrosis factor blockade with etanercept.
The Journal of rheumatology
PubMed: 15229937
07/2004

Lack of Evidence of Encephalopathy Related to Pertussis Vaccine : Active Surveillance by IMPACT, Canada, 1993–2002
The Pediatric Infectious Disease Journal
Dorothy L. Moore, Nicole Le Saux, David Scheifele, Scott A. Halperin
DOI: 10.1097/01.inf.0000130075.56368.02
06/2004

For coughs, colds and SARS, wear a mask.
Paediatrics & child health
DOI: 10.1093/pch/8.10.601
PubMed: 20019847
12/2003

Injection-site reactions to booster doses of acellular pertussis vaccine: rate, severity, and anticipated impact.
Pediatrics
DOI: 10.1542/peds.112.6.e453
PubMed: 14654644
12/2003

Predictors of death in infants hospitalized with pertussis: a case-control study of 16 pertussis deaths in Canada
The Journal of Pediatrics
Lynda K Mikelova, Scott A Halperin, David Scheifele, Bruce Smith, Elizabeth Ford-Jones, Wendy Vaudry, Taj Jadavji, Barbara Law, Dorothy Moore
DOI: 10.1067/s0022-3476(03)00365-2
11/2003

Decrease in hospital admissions for febrile seizures and reports of hypotonic-hyporesponsive episodes presenting to hospital emergency departments since switching to acellular pertussis vaccine in Canada: a report from IMPACT.
Pediatrics
DOI: 10.1542/peds.112.5.e348
PubMed: 14595075
11/2003

Randomized, double-blind, placebo-controlled trial to assess the rate of recurrence of oculorespiratory syndrome following influenza vaccination among persons previously affected.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
DOI: 10.1086/378274
PubMed: 14523770
10/2003

Immunization monitoring program, active: a model of active surveillance of vaccine safety
Seminars in Pediatric Infectious Diseases
David W Scheifele, Scott A Halperin
DOI: 10.1016/s1045-1870(03)00036-0
07/2003

Nature, evolution, and appraisal of adverse events and antibody response associated with the fifth consecutive dose of a five-component acellular pertussis-based combination vaccine
Vaccine
Scott A. Halperin, David Scheifele, Elaine Mills, Roland Guasparini, Garry Humphreys, Luis Barreto, Bruce Smith
DOI: 10.1016/s0264-410x(03)00173-7
06/2003

Ocular and Respiratory Symptoms Attributable to Inactivated Split Influenza Vaccine: Evidence from a Controlled Trial Involving Adults
Clinical Infectious Diseases
David W. Scheifele, Bernard Duval, Margaret L. Russell, Richard Warrington, Gaston DeSerres, Danuta M. Skowronski, Marc Dionne, James Kellner, Dele Davies, Judy MacDonald
DOI: 10.1086/368189
04/2003

Invasive pneumococcal infections among Canadian aboriginal children.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 12632794
03/2003

Canada needs a national immunization program: an open letter to the Honourable Anne McLellan, federal minister of health.
CMAJ : Canadian Medical Association Journal
PubMed: 12615750
03/2003

Thrombocytopenia after immunization of Canadian children, 1992 to 2001
The Pediatric Infectious Disease Journal
TAJ JADAVJI, DAVID SCHEIFELE, SCOTT HALPERIN
DOI: 10.1097/01.inf.0000048961.08486.d1
02/2003

Thrombocytopenia after immunization of Canadian children, 1992 to 2001.
The Pediatric infectious disease journal
DOI: 10.1097/00006454-200302000-00006
PubMed: 12586974
02/2003

Unique roles of a data and safety monitoring board in vaccine safety trials with compressed timelines and urgent implications
Controlled Clinical Trials
David Scheifele, Bernard Duval, Gaston De Serres, Danuta M Skowronski
DOI: 10.1016/s0197-2456(02)00269-6
02/2003

Three-year follow-up of protection rates in children given varicella vaccine.
The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses
DOI: 10.1155/2002/907087
PubMed: 18159415
11/2002

Assuring vaccine safety: A celebration of 10 years of progress with the IMPACT project.
Paediatrics & child health
PubMed: 20046444
11/2002

Outcome of penicillin-nonsusceptible Streptococcus pneumoniae meningitis: a nested case-control study
The Pediatric Infectious Disease Journal
JAMES D. KELLNER, DAVID W. SCHEIFELE, SCOTT A. HALPERIN, MARC H. LEBEL, DOROTHY MOORE, NICOLLE LE SAUX, E. LEE FORD-JONES, BARBARA LAW, WENDY VAUDRY
DOI: 10.1097/00006454-200210000-00004
10/2002

Population-based epidemiology of invasive pneumococcal infection in children in nine urban centers in Canada, 1994 through 1998
The Pediatric Infectious Disease Journal
GORDEAN L. BJORNSON, DAVID W. SCHEIFELE, SCOTT A. HALPERIN
DOI: 10.1097/00006454-200210000-00012
10/2002

Hepatitis A vaccine: is it being used to best advantage?
CMAJ : Canadian Medical Association Journal
PubMed: 12137079
07/2002

Pelvic inflammatory disease associated with Enterobius vermicularis.
Archives of Disease in Childhood
DOI: 10.1136/adc.86.6.439
PubMed: 12023182
06/2002

Emergence of penicillin-nonsusceptible Streptococcus pneumoniae invasive clones in Canada.
Journal of clinical microbiology
DOI: 10.1128/jcm.40.1.68-74.2002
PubMed: 11773094
01/2002

Meningococcal disease and vaccination in North America.
Journal of paediatrics and child health
DOI: 10.1046/j.1440-1754.2001.00679.x
PubMed: 11885732
10/2001

Historic low Haemophilus influenzae type B case tally--Canada 2000.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 11582620
09/2001

Assessment of injection site reactions to an acellular pertussis-based combination vaccine, including novel use of skin tests with vaccine antigens
Vaccine
David W. Scheifele, Scott A. Halperin, Alexander C. Ferguson
DOI: 10.1016/s0264-410x(01)00230-4
09/2001

Reduced susceptibility to penicillin among pneumococci causing invasive infection in children - Canada, 1991 to 1998.
The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses
DOI: 10.1155/2001/984958
PubMed: 18159346
07/2001

Population-based surveillance of invasive group A streptococcal disease in British Columbia: 1996 to 1998.
The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses
DOI: 10.1155/2001/270873
PubMed: 18159345
07/2001

Practical vaccination guidelines for children with cancer.
Paediatrics & child health
PubMed: 20084264
07/2001

Random Gleanings from the Literature
Paediatrics & Child Health
David W Scheifele
DOI: 10.1093/pch/6.4.199
04/2001

Hib conjugate vaccines: lessons learned.
International journal of clinical practice. Supplement
PubMed: 11715364
02/2001

Pneumococcal disease: Implications in paediatrics
Paediatrics & Child Health
David Scheifele
DOI: 10.1093/pch/6.suppl_b.4b
2001

The burden of pneumococcal infections in children
Paediatrics & Child Health
David Scheifele
DOI: 10.1093/pch/6.suppl_b.5b
2001

The Immunization Monitoring Program Active (IMPACT) prospective five year study of Canadian children hospitalized for chickenpox or an associated complication.
The Pediatric infectious disease journal
DOI: 10.1097/00006454-200011000-00005
PubMed: 11099085
11/2000

New vaccines and the rising costs of caring
Paediatrics & Child Health
David W Scheifele
DOI: 10.1093/pch/5.7.371
10/2000

Population-based incidence rate of invasive pneumococcal infection in children: Vancouver, 1994-1998.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 11042949
09/2000

The Immunization Monitoring Program-active (IMPACT) prospective surveillance of varicella zoster infections among hospitalized Canadian Children: 1991-1996.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 10946445
08/2000

Invasive pneumococcal infections in Canadian children, 1991-1998: implications for new vaccination strategies. Canadian Paediatric Society/Laboratory Centre for Disease Control Immunization Monitoring Program, Active (IMPACT).
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
DOI: 10.1086/313923
PubMed: 10913397
07/2000

Haemophilus influenzae type B disease control using PENTACEL, Canada, 1998-1999.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 10920538
06/2000

Population-based surveillance of Hib invasive infections in children in British Columbia Alberta and Ontario - 1995 to 1997.
The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses
DOI: 10.1155/2000/219612
PubMed: 18159280
05/2000

Adult formulation of a five component acellular pertussis vaccine combined with diphtheria and tetanus toxoids and inactivated poliovirus vaccine is safe and immunogenic in adolescents and adults.
The Pediatric infectious disease journal
DOI: 10.1097/00006454-200004000-00003
PubMed: 10783014
04/2000

School-based hepatitis B vaccination programme and adolescent multiple sclerosis
The Lancet
A Dessa Sadovnick, David W Scheifele
DOI: 10.1016/s0140-6736(99)02991-8
02/2000

Reactogenicity to a Live Attenuated Varicella Vaccine in Canadian Children
Canadian Journal of Infectious Diseases
Francisco Diaz-Mitoma, Scott A Halperin, David Scheifele
DOI: 10.1155/2000/647245
2000

Evaluation of ready-to-use and multi-dose influenza vaccine formats in large clinic settings.
Canadian journal of public health = Revue canadienne de sante publique
PubMed: 11089283
2000

Effect of reminder notices on the timeliness of early childhood immunizations.
Paediatrics & child health
PubMed: 20212950
09/1999

Comparison of a fifth dose of a five-component acellular or a whole cell pertussis vaccine in children four to six years of age
The Pediatric Infectious Disease Journal
SCOTT A. HALPERIN, DAVID SCHEIFELE, LUIS BARRETO, CAROLYN PIM, ROLAND GUASPARINI, LORNA MEDD, WILLIAM MEEKISON, BRIAN J. EASTWOOD
DOI: 10.1097/00006454-199909000-00006
09/1999

Extended follow-up of antibody levels and antigen responsiveness after 2 Haemophilus influenzae type b conjugate vaccines
The Journal of Pediatrics
David W. Scheifele, Scott A. Halperin, Roland Guasparini, William Meekison, Carolyn Pim, Luis Barreto
DOI: 10.1016/s0022-3476(99)70028-4
08/1999

How to increase by 40% the number of pediatric doses recovered from multidose vials of Hepatitis B vaccines
The Pediatric Infectious Disease Journal
DOI: 10.1097/00006454-199906000-00020
06/1999

Epidemiological features of pertussis in hospitalized patients in Canada, 1991-1997: report of the Immunization Monitoring Program--Active (IMPACT).
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
DOI: 10.1086/514792
PubMed: 10451159
06/1999

Genotyping of Penicillin-Highly Resistant Invasive Streptococcus pneumoniae Obtained from Canadian Children Early in the Resistance Epidemic
Pediatric Research
David Greenberg, Eshwar Mahenthiralingam, Jim D Kellner, Maureen E Campbell, Debrah A Henry, David P Speert, David W Scheifele
DOI: 10.1203/00006450-199904020-00958
04/1999

Cow tails and conviction (review of Viruses, plagues, and history).
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
02/1999

A comparative study of PENTA™ vaccine booster doses given at 12, 15 or 18 months of age
Vaccine
David W Scheifele, Roland Guasparini, Pierre Lavigne
DOI: 10.1016/s0264-410x(98)00232-1
02/1999

Haemophilus influenzae type B disease at 11 pediatric centres, 1996-1997.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 9926485
07/1998

Universal childhood hepatitis B vaccination: infants vs. preadolescents, the Canadian perspective
The Pediatric Infectious Disease Journal
DAVID SCHEIFELE
DOI: 10.1097/00006454-199807001-00004
07/1998

On caring and counting
Paediatrics & Child Health
David W Scheifele
DOI: 10.1093/pch/3.4.221
07/1998

On caring and counting.
Paediatrics & child health
PubMed: 20401248
07/1998

Disseminated bacille Calmette-Guérin infection: three recent Canadian cases. IMPACT. Immunization Monitoring Program, Active.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 9611413
05/1998

Comparative safety of tetanus-diphtheria toxoids booster immunization in students in Grades 6 and 9
The Pediatric Infectious Disease Journal
DAVID W. SCHEIFELE, SIMON DOBSON, ARLENE KALLOS, GORDEAN BJORNSON, JAN J. OCHNIO
DOI: 10.1097/00006454-199812000-00004
1998

Immunization. Point, counterpoint.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
PubMed: 9418668
12/1997

Clinical trials and tribulations: a personal view of interacting with pharmaceutical manufacturers.
Clinical and investigative medicine. Medecine clinique et experimentale
PubMed: 9189650
06/1997

Hypotonic-hyporesponsive episodes in children hospitalized at 10 Canadian Pediatric Tertiary-Care Centres, 1991-1994.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 9540236
05/1997

Pediatric investigators collaborative network on infections in Canada (PICNIC): The politics and positives of a cooperative study group
Journal of Clinical Epidemiology
Elaine E.L. Wang, David Scheifele, Barbara J. Law, Noni E. MacDonald
DOI: 10.1016/s0895-4356(96)00382-4
04/1997

New, ultrasensitive enzyme immunoassay for detecting vaccine- and disease-induced hepatitis A virus-specific immunoglobulin G in saliva.
Journal of clinical microbiology
PubMed: 8968887
01/1997

Hepatitis A Virus Infections in Urban Children—Are Preventive Opportunities Being Missed?
The Journal of Infectious Diseases
Jan J. Ochnio, David W. Scheifele, Margaret Ho
DOI: 10.1086/514162
1997

Assessment of parent education methods for infant immunization.
Canadian journal of public health = Revue canadienne de sante publique
PubMed: 9458569
1997

Study of booster doses of two Haemophilus influenzae type b conjugate vaccines including their interchangeability.
Vaccine
DOI: 10.1016/s0264-410x(96)00086-2
PubMed: 8994313
10/1996

Penicillin resistance among invasive pneumococcal isolates at 10 children's hospitals, 1991-1994. The LCDC/CPS Impact Group. The Immunization Monitoring Program, Active.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 8917965
10/1996

Recent trends in pediatric Haemophilus influenzae type B infections in Canada. Immunization Monitoring Program, Active (IMPACT) of the Canadian Paediatric Society and the Laboratory Centre for Disease Control.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
PubMed: 8625025
04/1996

DOES TREATMENT WITH DEXAMETHASONE AFFECT THE IMMUNOLOGICAL RESPONSE TO ANTIGENIC CHALLENGE OF INFANTS BORN PRETERM? 1717
Pediatric Research
Abbas R.M Kingo, David Scheifele, Margaret Pendray, Dan Waisman, Ruth Milner
DOI: 10.1203/00006450-199604001-01741
04/1996

Failures after immunization with Haemophilus influenzae type b vaccines--1991-1995.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 8822260
02/1996

Where is the Varicella Vaccine?
Canadian Journal of Infectious Diseases
David W Scheifele
DOI: 10.1155/1996/151890
1996

Assessment of a universal, school-based hepatitis B vaccination program.
JAMA
DOI: 10.1001/jama.1995.03530150033030
PubMed: 7563510
10/1995

Effects of freezing on DPT and DPT-IPV vaccines, adsorbed.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 7647743
06/1995

Safety and effectiveness of the new inactivated hepatitis A virus vaccine.
CMAJ : Canadian Medical Association Journal
PubMed: 7828098
02/1995

Evaluation of booster doses of Haemophilus influenzae type b-tetanus toxoid conjugate vaccine in 18-month-old children
Vaccine
David W. Scheifele, William Meekison, Roland Guasparini, Ann Roberts, Luis Barreto, John Thipphawong, Sharon Wiltsey
DOI: 10.1016/0264-410x(95)80019-a
01/1995

Immunization of patients with rheumatoid arthritis against influenza: a study of vaccine safety and immunogenicity.
The Journal of rheumatology
PubMed: 7966058
07/1994

Safety and immunogenicity of Haemophilus influenzae vaccine (tetanus toxoid conjugate) administered concurrently or combined with diphtheria and tetanus toxoids, pertussis vaccine and inactivated poliomyelitis vaccine to healthy infants at two, four and six months of age.
The Pediatric infectious disease journal
PubMed: 8072815
05/1994

Haemophilus B conjugate vaccination failure.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 8193604
03/1994

Evaluation of Haemophilus influenzae type b conjugate vaccine (meningococcal protein conjugate) in Canadian infants.
The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses
DOI: 10.1155/1994/479313
PubMed: 22451769
03/1994

Pertussis in children hospitalized at five Canadian pediatric tertiary care centres.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 8167606
02/1994

Local adverse effects of meningococcal vaccine.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
PubMed: 8275404
01/1994

Meningococcal disease in children hospitalized at six Canadian pediatric tertiary care centres.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 8161973
01/1994

Role of whole-cell pertussis vaccine in severe local reactions to the preschool (fifth) dose of diphtheria-pertussis-tetanus vaccine.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
PubMed: 8275406
01/1994

The Changing Face of Childhood Meningitis
Canadian Journal of Infectious Diseases
David Scheifele
DOI: 10.1155/1994/598491
1994

Dissenting Views on Dexamethasone Therapy for Bacterial Meningitis
Canadian Journal of Infectious Diseases
David W Scheifele
DOI: 10.1155/1994/565214
1994

Is Haemophilus influenzae type b conjugate vaccine (meningococcal protein conjugate) compatible with diphtheria-pertussis-tetanus vaccine in young infants?
The Pediatric infectious disease journal
PubMed: 8265288
11/1993

Influenza immunization in children with chronic arthritis: a prospective study.
The Journal of rheumatology
PubMed: 7848389
10/1993

Can Haemophilus influenzae type b-tetanus toxoid conjugate vaccine be combined with diphtheria toxoid-pertussis vaccine-tetanus toxoid?
CMAJ : Canadian Medical Association Journal
PubMed: 8221449
10/1993

Decline in Haemophilus influenzae type B invasive infections at five Canadian pediatric centres.
Canada communicable disease report = Releve des maladies transmissibles au Canada
PubMed: 8348103
06/1993

Immunogenicity of Haemophilus influenzae type b conjugate vaccine in children with congenital asplenia.
The Journal of infectious diseases
DOI: 10.1093/infdis/167.5.1210
PubMed: 8486956
05/1993

Evaluation of inactivated hepatitis A vaccine in Canadians 40 years of age or more.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
PubMed: 8431816
02/1993

A Perspective on Vaccine Evaluation Research in Canada: Past and Future
Canadian Journal of Infectious Diseases
David W Scheifele, Aubrey J Tingle
DOI: 10.1155/1993/384058
1993

Breastfeeding and antibody responses to routine vaccination in infants.
Lancet (London, England)
DOI: 10.1016/0140-6736(92)92589-8
PubMed: 1360102
12/1992

Acellular versus whole-cell pertussis vaccines.
The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses
DOI: 10.1155/1992/564683
PubMed: 22529731
03/1992

Pediatric immunization for the 1990s.
The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses
DOI: 10.1155/1992/838160
PubMed: 22451753
01/1992

Controlled trial of Haemophilus influenzae type B diphtheria toxoid conjugate combined with diphtheria, tetanus and pertussis vaccines, in 18-month-old children, including comparison of arm versus thigh injection
Vaccine
David Scheifele, Gordean Bjornson, Luis Barreto, William Meekison, Roland Guasparini
DOI: 10.1016/0264-410x(92)90394-y
01/1992

Adverse reactions to the preschool (fifth) dose of adsorbed diphtheria-pertussis-tetanus vaccine in Canadian children.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
PubMed: 1893319
09/1991

Comparison of adverse reactions to whole-virion and split-virion influenza vaccines in hospital personnel.
CMAJ : Canadian Medical Association Journal
PubMed: 2070311
08/1991

Evaluation of poliovirus-related cases occurring in Canada in 1989.
Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada
PubMed: 2060033
04/1991

Role of bacterial toxins in neonatal necrotizing enterocolitis
The Journal of Pediatrics
David W. Scheifele
DOI: 10.1016/s0022-3476(05)81129-1
07/1990

Amino acid sequence of a deltalike toxin from Staphylococcus epidermidis.
Infection and immunity
PubMed: 2323825
05/1990

Neonatal necrotizing enterocolitis associated with delta toxin-producing methicillin-resistant Staphylococcus aureus.
The Pediatric infectious disease journal
PubMed: 2314957
02/1990

Neonatal necrotizing enterocolitis associated with delta toxin-producing methicillin-resistant Staphylococcus aureus
The Pediatric Infectious Disease Journal
GARY D. OVERTURF, MICHAEL P. SHERMAN, DAVID W. SCHEIFELE, LOUISE C. WONG
DOI: 10.1097/00006454-199002000-00005
02/1990

Evaluation of adverse events after influenza vaccination in hospital personnel.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
PubMed: 2295029
01/1990

Antigenuria after receipt of Haemophilus b diphtheria toxoid conjugate vaccine.
The Pediatric infectious disease journal
PubMed: 2626290
12/1989

Evaluation of Canadian poliovirus-related cases.
Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada
PubMed: 2791077
09/1989

Post-marketing surveillance of adverse events following ProHIBit vaccine--British Columbia.
Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada
PubMed: 2791073
07/1989

Local adverse reactions to adsorbed DPT vaccine--Surrey, British Columbia.
Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada
PubMed: 2706693
04/1989

Bravo!: Vaccines.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
04/1989

Herpes simplex type 2 aseptic meningitis in a two-month-old infant.
The Pediatric infectious disease journal
PubMed: 2540478
03/1989

ANTIGENURIA AFTER RECEIPT OF HAEMOPHILUS b DIPHTHERIA TOXOID CONJUGATE VACCINE
The Pediatric Infectious Disease Journal
David Scheifele, Gordean L. G. Bjornsen, Teri Arcand, Karen Jacobsen
DOI: 10.1097/00006454-198912000-00014
1989

Pertussis vaccine and encephalopathy after the Loveday trial.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
PubMed: 3263895
12/1988

Gentamicin penetration into cerebrospinal fluid in experimental Haemophilus influenzae meningitis.
Antimicrobial agents and chemotherapy
DOI: 10.1128/aac.32.7.1034
PubMed: 3190192
07/1988

Vaccines for prevention of head and neck infections.
Infectious disease clinics of North America
PubMed: 3074113
03/1988

Delta toxin activity in coagulase-negative staphylococci from the bowels of neonates.
Journal of clinical microbiology
PubMed: 3343323
02/1988

The contribution of coagulase-negative staphylococci to neonatal necrotizing enterocolitis
Infectious Diseases Newsletter
David W. Scheifele
DOI: 10.1016/0278-2316(88)90010-2
01/1988

Delta-like toxin produced by coagulase-negative staphylococci is associated with neonatal necrotizing enterocolitis.
Infection and immunity
PubMed: 3623702
09/1987

Early onset Campylobacter sepsis in a neonate.
The Pediatric infectious disease journal
PubMed: 3601501
05/1987

Staphylococcus epidermidis-associated enterocolitis
The Journal of Pediatrics
David Scheifele, Gordean Bjornson
DOI: 10.1016/s0022-3476(87)80185-3
02/1987

Comparison of two antibiotic regimens for neonatal necrotizing enterocolitis
Journal of Antimicrobial Chemotherapy
David W. Scheifele, Gordean L. Ginter, Edna Olsen, Susan Fussell, Margaret Pendray
DOI: 10.1093/jac/20.3.421
1987

Serious Pasteurella multocida infections from lion and tiger bites.
JAMA
DOI: 10.1001/jama.1985.03350460096030
PubMed: 3999316
06/1985

Lack of nosocomial spread of Varicella in a pediatric hospital with negative pressure ventilated patient rooms.
Infection control : IC
PubMed: 3845064
03/1985

Spontaneous endotoxinemia in premature infants: correlations with oral feeding and bowel dysfunction.
Journal of pediatric gastroenterology and nutrition
PubMed: 3981371
02/1985

Spontaneous Endotoxinemia in Premature InfantsCorrelations with Oral Feeding and Bowel Dysfunction
Journal of Pediatric Gastroenterology and Nutrition
David W. Scheifele, Edna Olsen, Susan Fussell, Margaret Pendray
DOI: 10.1097/00005176-198502000-00013
02/1985

Endotoxinemia and Thrombocytopenia during Neonatal Necrotizing Enterocolitis
American Journal of Clinical Pathology
David W. Scheifele, Edna M. Olsen, Margaret R. Pendray
DOI: 10.1093/ajcp/83.2.227
02/1985

Animal bites causing central nervous system injury in children. A report of three cases.
Pediatric neuroscience
PubMed: 3837882
1985

Evaluation of Skin Antisepsis Prior to Blood Culture in Neonates
Infection Control
Sylvie Champagne, Susan Fussell, David Scheifele
DOI: 10.1017/s0195941700060902
10/1984

Odontogenic infections
The Pediatric Infectious Disease Journal
DAVID W. MEGRAN, DAVID W. SCHEIFELE, ANTHONY W. CHOW
DOI: 10.1097/00006454-198405000-00018
05/1984

Variant postpartum toxic shock syndrome with probable intrapartum transmission to the neonate.
American journal of obstetrics and gynecology
DOI: 10.1016/s0002-9378(84)90448-4
PubMed: 6711641
04/1984

Odontogenic infections.
Pediatric infectious disease
PubMed: 6377257
1984

Bacterial endotoxins in umbilical cord blood of neonates.
Biology of the neonate
PubMed: 6367839
1984

Bacterial Endotoxins in Umbilical Cord Blood of Neonates
Neonatology
David W. Scheifele, Susan Fussell, Edna Olsen
DOI: 10.1159/000241885
1984

Potential significance of colonization with beta-lactamase-producing Haemophilus parainfluenzae in children.
European journal of clinical microbiology
DOI: 10.1007/bf02029515
PubMed: 6349987
06/1983

Prophylactic antibiotics in children
The Pediatric Infectious Disease Journal
DAVID W. SCHEIFELE
DOI: 10.1097/00006454-198211000-00013
11/1982

Update on antibiotic resistance of Haemophilus influenzae in Canada.
Canadian Medical Association journal
PubMed: 6980695
08/1982

Characterization of ampicillin-resistant Haemophilus parainfluenzae.
Antimicrobial agents and chemotherapy
DOI: 10.1128/aac.21.5.734
PubMed: 6980626
05/1982

Prophylactic antibiotics in children.
Pediatric infectious disease
PubMed: 6761659
1982

Advantage of latex agglutination over countercurrent immunoelectrophoresis in the detection of Haemophilus influenzae type b antigen in serum.
Pediatrics
PubMed: 6976554
12/1981

Evaluation of the Limulus test for endotoxemia in neonates with suspected sepsis
The Journal of Pediatrics
David W. Scheifele, Patrick Melton, Valerie Whitchelo
DOI: 10.1016/s0022-3476(81)80582-3
06/1981

Ampicillin-resistant Haemophilus influenzae colonizing ambulatory children.
American journal of diseases of children (1960)
PubMed: 6972159
05/1981

Ampicillin-Resistant Haemophilus influenzae Colonizing Ambulatory ChildrenEpidemiology and Implications for Otitis Media Therapy
American Journal of Diseases of Children
David W. Scheifele
DOI: 10.1001/archpedi.1981.02130290004002
05/1981

Loss of plasmid DNA coding for beta-lactamase during experimental infection with Haemophilus influenzae type b.
The Journal of infectious diseases
DOI: 10.1093/infdis/143.4.548
PubMed: 6972420
04/1981

Frequency of ampicillin-resistant Haemophilus parainfluenzae in children.
The Journal of infectious diseases
DOI: 10.1093/infdis/143.3.495
PubMed: 6785367
03/1981

Endotoxinaemia per se as cause of neonatal morbidity.
Lancet (London, England)
DOI: 10.1016/s0140-6736(81)91962-0
PubMed: 6109984
02/1981

Prevention and treatment of influenza A with amantadine hydrochloride.
Canadian Medical Association journal
PubMed: 7448670
11/1980

Streptococcal neonatal osteomyelitis.
American journal of diseases of children (1960)
PubMed: 6994488
07/1980

Airborne transmission of chickenpox.
The New England journal of medicine
PubMed: 7383115
07/1980

Haemophilus influenzae bacteremia and meningitis in infant primates.
The Journal of laboratory and clinical medicine
PubMed: 6766493
03/1980

Comparison of two antigen detection techniques in a primate model of Haemophilus influenzae type b infection.
Infection and immunity
PubMed: 118934
12/1979

Effect of inoculum size on the susceptibility of Haemophilus influenzae b to beta-lactam antibiotics.
Antimicrobial agents and chemotherapy
DOI: 10.1128/aac.16.4.510
PubMed: 316308
10/1979

Ampicillin-resistant Hemophilus influenzae in Canada: nationwide survey of hospital laboratories.
Canadian Medical Association journal
PubMed: 316354
07/1979

Rapid diagnosis of Hemophilus influenzae type b infections by latex particle agglutination and counterimmunoelectrophoresis
The Journal of Pediatrics
Joel I. Ward, George R. Siber, David W. Scheifele, David H. Smith
DOI: 10.1016/s0022-3476(78)80596-4
07/1978

Increasing incidence of ampicillin resistance in Hemophilus influenzae
The Journal of Pediatrics
Vassiliki Syriopoulou, David Scheifele, Arnold L. Smith, Patricia M. Perry, Virgil Howie
DOI: 10.1016/s0022-3476(78)80354-0
06/1978

Home-testing for recurrent bacteriuria, using nitrite strips.
American journal of diseases of children (1960)
PubMed: 623064
01/1978

Home-Testing for Recurrent Bacteriuria, Using Nitrite Strips
Archives of Pediatrics & Adolescent Medicine
David W. Scheifele
DOI: 10.1001/archpedi.1978.02120260048013
01/1978

Ventricular involvement in experimental Hemophilus influenzae meningitis
The Journal of Pediatrics
Robert S. Daum, David W. Scheifele, Vassiliki Ph. Syriopoulou, Damon Averill, Arnold L. Smith
DOI: 10.1016/s0022-3476(78)81213-x
1978

RAPID DIAGNOSIS OF H. INFLUENZAE TYPE B (HIB) INFECTIONS BY LATEX PARTICLE AGGLUTINATION (LPA) AND COUNTER IMMUNOELECTROPHORESIS (CIE)
Pediatric Research
Joel I Ward, George R Siber, David W Scheifele, David H Smith
DOI: 10.1203/00006450-197704000-00834
04/1977

Incidence of ampicillin-resistant Hemophilus influenzae in otitis media
The Journal of Pediatrics
Vassiliki Syriopoulou, David Scheifele, Virgil Howie, John Ploussard, John Sloyer, Arnold L. Smith
DOI: 10.1016/s0022-3476(76)80821-9
11/1976

Evaluation of a rapid beta-lactamase test for detecting ampicillin-resistant strains of Hemophilus influenzae type b.
Pediatrics
PubMed: 1085435
09/1976

Otitis media caused by non-typable, ampicillin-resistant strains of Haemophilus influenzae
The Journal of Pediatrics
Paul A. Shurin, Stephen I. Pelton, David Scheifele, Jerome O. Klein
DOI: 10.1016/s0022-3476(76)80028-5
04/1976

The management of measles in Nairobi.
East African medical journal
PubMed: 4724679
03/1973

Current concepts. The biology of measles in African children.
East African medical journal
PubMed: 4724680
03/1973

Prolonged giant cell excretion in severe African measles.
Pediatrics
PubMed: 4636453
12/1972

Epidemiology of Meningococcal Disease in North America
Meningococcal Disease
Andrew J. Pollard, David Scheifele, Nancy Rosenstein
DOI: 10.1385/1-59259-149-3:341

Research

Current Projects
I am the data centre supervisor for the Immunization Monitoring Program, Active (IMPACT), an active surveillance program involving 12 pediatric centers across Canada. This project is funded by the Public Health Agency of Canada and operated by the Canadian Pediatric Society and its specialist members in infectious diseases. Nurse monitors at each hospital actively search for admissions with adverse events following immunization, to assess causes and outcomes. This is a key means of assessing vaccine safety, particularly the occurrence of uncommon, severe reactions. Monitors also report on selected vaccine preventable diseases, as a measure of vaccine program effectiveness. Surveillance presently includes varicella, pertussis, invasive pneumococcal, meningococcal rotavirus and influenza admissions.

I was co-leader of the PHAC/CIHR Influenza Research Network (PCIRN), responsible for the Clinical Trials activities. PCIRN was established in April 2009 to prepare for necessary investigations during an influenza pandemic and was quickly re-tasked in May 2009 to focus on the H1N1 pandemic. The PCIRN network carried out 4 trials of pH1N1 vaccine in late 2009 involving over 700 subjects at 13 centers across Canada. Related studies continued in 2010 and 2011, the legacy from which will be an advanced state of preparedness for studies in a public health emergency.

Honours & Awards

Officer of the Order of Canada – 2013

Queen Elizabeth II Golden Jubilee Medal – 2013