George Michaiel

Overview: My primary area of clinical research is in the treatment and long term care of children with brain and spinal cord tumors, with a specific interest in high grade glioma. Through participation in various consortiums and research groups, I am involved locally in the conduct of clinical trials for patients with newly diagnosed and recurrent tumors. I hope to expand our patients' access to early phase and innovative therapies, including immunotherapy, particularly for difficult to treat tumors.
Publications: Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation Sparing Approaches: An International Cohort Study
Journal of Clinical Oncology
DOI: 10.1200/JCO.21.02968
2023
A Case of Primary Intracranial Sarcoma, DICER1-Mutant, in a Child with a Germline DICER1 Mutation
Brain Sciences
DOI: 10.3390/brainsci13071040
2023
3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma
Nature Communications
DOI: 10.1038/s41467-023-38044-0
2023
Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma
Neuro-oncology
Rosenberg, T. and Yeo, K.K. and Mauguen, A. and Alexandrescu, S. and Prabhu, S.P. and Tsai, J.W. and Malinowski, S. and Joshirao, M. and Parikh, K. and Farouk Sait, S. and Rosenblum, M.K. and Benhamida, J.K. and Michaiel, G. and Tran, H.N. and Dahiya, S. and Kachurak, K. and Friedman, G.K. and Krystal, J.I. and Huang, M.A. and Margol, A.S. and Wright, K.D. and Aguilera, D. and MacDonald, T.J. and Chi, S.N. and Karajannis, M.A.
DOI: 10.1093/neuonc/noac096
2022
Multi-institutional analysis of central nervous system germ cell tumors in patients with Down syndrome
Research Square
DOI: 10.21203/rs.3.rs-1538410/v1
2022
Multi-institutional analysis of central nervous system germ cell tumors in patients with Down syndrome
Pediatric Blood and Cancer
Harris, M.K. and Graham, R.T. and Cappellano, A.M. and Margol, A.S. and Michaiel, G. and Crawford, J.R. and Ioakeim-Ioannidou, M. and Stanek, J.R. and Liu, K.X. and MacDonald, S.M. and Abdelbaki, M.S.
DOI: 10.1002/pbc.29830
2022
Multi-institutional analysis of central nervous system germ cell tumors in patients with Down syndrome
ResearchSquare
Harris, M.K. and Graham, R.T. and Cappellano, A.M. and Margol, A.S. and Michaiel, G. and Crawford, J.R. and Ioakeim-Ioannidou, M. and Stanek, J.R. and Liu, K.X. and MacDonald, S.M. and Abdelbaki, M.S.
DOI: 10.21203/rs.3.rs-1538410
2022
Intracranial growing teratoma syndrome (iGTS): an international case series and review of the literature
Journal of Neuro-Oncology
Michaiel, G. and Strother, D. and Gottardo, N. and Bartels, U. and Coltin, H. and Hukin, J. and Wilson, B. and Zelcer, S. and Hansford, J.R. and Hassall, T. and AbdelBaki, M.S. and Cole, K.A. and Hoffman, L. and Smiley, N.P. and Smith, A. and Vinitsky, A. and Vitanza, N.A. and Wright, A. and Yeo, K.K. and Chow, L.M.L. and Vanan, M.I. and Dhall, G. and Bouffet, E. and Lafay-Cousin, L.
DOI: 10.1007/s11060-020-03486-9
2020
Health Practitioners Knowledge, Beliefs, and Attitudes Regarding the Use of Donor Human Milk in Neonatal Intensive Care
Maternal and Pediatric Nutrition
Michael G and Antunes M and Shaik S and Turner J
DOI: 10.4172/2472-1182.1000108
2016
Two promoters with distinct activities in different tissues drive the expression of heparanase in Xenopus
Developmental Dynamics
Bertolesi, G.E. and Su, H.Y. and Michaiel, G. and Dueck, S.M. and Hehr, C.L. and Mcfarlane, S.
DOI: 10.1002/dvdy.22770
2011
Two heparanase splicing variants with distinct properties are necessary in early Xenopus development
Journal of Biological Chemistry
Bertolesi, G.E. and Michaiel, G. and McFarlane, S.
DOI: 10.1074/jbc.M708525200
2008
Research: Research Group Members

Carla Willems

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Crafting beating heart cells to deliver personalized treatments for kids with hypertrophic cardiomyopathy

Researchers at BC Children's Hospital Research Institute are working with human-induced pluripotent stem cells to develop safer and more effective treatments for kids with hypertrophic cardiomyopathy.

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Congratulations CIHR Spring 2024 Project Grant recipients

Congratulations to the BC Children’s Hospital Research Institute (BCCHR) and Women’s Health Research Institute (WHRI) investigators and their teams who were awarded $5 million in funding through the Canadian Institutes of Health Research (CIHR) Spring 2024 Project Grant competition.

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Torin Halvorson and Hebah Hussaina awarded Vanier scholarships for immunotherapy and mental health research

BC Children’s Hospital Research Institute (BCCHR) is proud to announce that two of its outstanding research trainees, Torin Halvorson, an MD/PhD student working with the Levings research team, and Hebah Hussaina, a graduate research assistant in the Brussoni Lab, have been awarded the prestigious 2024 Vanier Canada Graduate Scholarship.

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Collaboration was key to discovery about newborn immunity

Investigators at the BC Children’s Hospital Research Institute have made a finding that could eventually lead to therapeutic interventions for sepsis, lung disease, and other complications in premature newborns.

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A safer treatment path for high-risk children to overcome food allergies

New research from BC Children’s Hospital Research Institute and UBC reveals a safe path to overcoming food allergies for older children or building resistance for those who can’t risk consuming allergens. It’s called sublingual immunotherapy (SLIT), and it involves placing small amounts of food allergens under the tongue.

Continue reading A safer treatment path for high-risk children to overcome food allergies

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