One of my current research projects aims to identify research outcomes after surgery that are most valued by patients, parents and healthcare workers. Another project aims to investigate the safety and effectiveness of blood salvage techniques during bone cancer surgery in children.


Counting: An imprecise reference standard for respiratory rate measurement
Pediatric Pulmonology
J Mark Ansermino and Amy Sarah Ginsburg and Dustin Dunsmuir and Walter Karlen and Heng Gan and Catherine Muthoni Njeru and Guy A Dumont
DOI: 10.1002/ppul.26208

Are respiratory rate counters really so bad? Throwing the baby out with the bath water.
DOI: 10.1016/j.eclinm.2019.09.013
PubMed: 31832612

Correction: Improving the Accuracy and Efficiency of Respiratory Rate Measurements in Children Using Mobile Devices
DOI: 10.1371/journal.pone.0118260

The Performance of a Mobile Phone Respiratory Rate Counter Compared to the WHO ARI Timer.
Journal of healthcare engineering
DOI: 10.1260/2040-2295.6.4.691
PubMed: 27010948

A cohort study of morbidity, mortality and health seeking behavior following rural health center visits by children under 12 in southwestern Uganda.
PloS one
DOI: 10.1371/journal.pone.0118055
PubMed: 25635947

Healthcare Engineering Defined: A White Paper.
Journal of healthcare engineering
DOI: 10.1260/2040-2295.6.4.635
PubMed: 27010831

Improving the accuracy and efficiency of respiratory rate measurements in children using mobile devices.
PloS one
DOI: 10.1371/journal.pone.0099266
PubMed: 24919062

Pediatric surgical camps as one model of global surgical partnership: a way forward.
Journal of pediatric surgery
DOI: 10.1016/j.jpedsurg.2014.02.069
PubMed: 24851771

Assessing the quality of manual respiratory rate measurements using mobile devices
IET Conference Publications
Karlen, W. and Wiens, M.O. and Gan, H. and Dunsmuir, D. and Chiu, M. and Dumont, G.A. and Ansermino, J.M.

Predicting fluid responsiveness in children: a systematic review.
Anesthesia and analgesia
DOI: 10.1213/ane.0b013e3182a9557e
PubMed: 24257389

Ultra-low-cost clinical pulse oximetry.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
DOI: 10.1109/embc.2013.6610140
PubMed: 24110327

Predicting fluid responsiveness in children: A systematic review
Anesthesia and Analgesia
Gan, H. and Cannesson, M. and Chandler, J.R. and Ansermino, J.M.
DOI: 10.1213/ANE.0b013e3182a9557e

Ultra-low-cost clinical pulse oximetry
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Petersen, C.L. and Gan, H. and Macinnis, M.J. and Dumont, G.A. and Ansermino, J.M.
DOI: 10.1109/EMBC.2013.6610140

Interactive visual analysis of intensive care unit data: Relationship between serum sodium concentration, its rate of change and survival outcome
GRAPP 2012 IVAPP 2012 - Proceedings of the International Conference on Computer Graphics Theory and Applications and International Conference on Information Visualization Theory and Applications
Matkovi?, K. and Gan, H. and Ammer, A. and Bennett, D. and Purgathofer, W. and Terblanche, M.


Core Outcomes in Children undergoing Anesthesia and Surgery: A multi-center stakeholder engagement study
• Researchers studying children undergoing anesthesia and surgery currently lack guidance about what outcomes are important to measure. As a result, a wide range of different outcomes are measured in their research, outcomes that have unclear relevance to children, parents, and their healthcare team.
• In this project we will be directly engaging members of these stakeholder groups to identify those outcomes that these stakeholders consider most important after surgery in children.
• The overall study aim is to ask key stakeholder groups to identify outcomes of greatest importance for pediatric patients undergoing anesthesia and surgery. Specifically, we will undertake surveys and semistructured interviews to gather views from pediatric surgical patients, their parents/guardians, and perioperative healthcare professionals about what outcomes are important.

Intra-operative Cell Salvage for Pediatric Bone Cancer Surgery
• Osteosarcoma and Ewing sarcoma are bone cancers that typically occur in children and are usually treated with a combination of surgery, chemotherapy, and radiotherapy. The possibility of major blood loss during the operation is high and transfusion of donated blood, with all the attendant risks, is often required.
• Intra-operative cell salvage refers to the collection, processing, and re-transfusion of blood lost during surgery. This well-established technique minimizes the need for transfusion of donated blood, but its adoption for cancer surgery has been limited by the theoretical risk of reintroducing tumor cells into the patient’s bloodstream. While recent evidence that a special filter effectively removes tumor cells from salvaged blood has led to increased use of cell salvage during cancer surgery in adults, its use in children remains uncommon.
• In a new collaboration between The Department of Anesthesia and The Department of Pathology and Laboratory Medicine, we propose a two-part study to investigate the safety and efficacy of cell salvage during bone cancer surgery in children. Phase I is laboratory based and will use flow cytometry to determine the lower limit of detection of tumor cells in blood. In Phase II we will use patient blood collected through cell salvage, with and without a filter, to determine the number of tumor cells present.

Honours & Awards

Thrasher Research Fund Early Career Award, 2012-2014

Best Poster Presentation, Association of Paediatric Anaesthetists Annual Scientific Meeting, 2015

Mobile Health & Ambient Assistive Technology Challenge (Bronze), Conference on Mobile and Information Technologies in Medicine and Health, Prague, 2014

Research Group Members

Bradley Hofmann, Summer Research Student
Alex Stolz, Clinical Research Assistant