Overview

My research interests are diverse but focused. I have a firm interest in bone tumors and a soft spot for soft tissue sarcomas, including understanding the underlying pathophysiology and translational work in the clinical pathology lab setting. I joined the 2019-2021 cohort within the Children’s Oncology Group Young Investigator Program with a focus in the bone tumor group. I also am interested in exploring cell signaling and cell-to-cell communication through conventional molecular and proteomic analysis with fellow investigators. My second area of research interest is in gastrointestinal pathology, particularly eosinophilic esophagitis (EoE). Through these EoE projects, I enjoyed expanding my experience in immunology which builds on an interest during my fellowship at Lurie Children’s Hospital of Chicago, which explored transplant immunology and the effect on the gastrointestinal tract. I also enjoy expanding my experience in the area of transplant immunology. My last primary area of interest is in developmental pathology, which often stems from identifying common pathologic findings in the interesting cases I encounter at BC Children’s and Women’s Hospital. I have an interest in leadership and administration, which blossomed during my time as Cohort 2 in the BC Patient Safety and Quality Council’s Clinician Quality Academy.

Publications

Novel Exonic Deletions in TTC7A in a Newborn with Multiple Intestinal Atresia and Combined Immunodeficiency
Journal of Clinical Immunology
Jessica R. Saunders and Anna Lehman and Stuart E. Turvey and Jie Pan and Evica Rajcan-Separovic and Aleixo M. Muise and Jonathan W. Bush
DOI: 10.1007/s10875-019-00669-6
08/2019

Loss of BRG1 (SMARCA4) Immunoexpression in a Pediatric Non-Central Nervous System Tumor Cohort
Pediatric and Developmental Pathology
DOI: 10.1177/1093526619869154
08/2019

Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE): A Case Report
Fetal and Pediatric Pathology
Cyrus L Matheson and Geoffrey K Blair and Jonathan Bush
DOI: 10.1080/15513815.2019.1600625
04/2019

Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in T regulatory cells
JCI Insight
DOI: 10.1172/jci.insight.123672
02/2019

Pediatric Pathology Fellowship Recruitment—Report of a Survey Conducted by the Fellowship Committee of the Society for Pediatric Pathology
Pediatric and Developmental Pathology
DOI: 10.1177/1093526617722905
2018

Pediatric Eosinophilic Esophagitis Is Associated With Increased Lamina Propria Immunoglobulin G4-Positive Plasma Cells
Journal of pediatric gastroenterology and nutrition
DOI: 10.1097/mpg.0000000000001949
2018

Eosinophilic density in graft biopsies positive for rejection and blood eosinophil count can predict development of post-transplant digestive tract eosinophilia
Pediatric Transplantation
DOI: 10.1111/petr.12693
2016

Treatment of neuroblastoma in congenital central hypoventilation syndrome with a PHOX2B polyalanine repeat expansion mutation: New twist on a neurocristopathy syndrome
Pediatric Blood and Cancer
DOI: 10.1002/pbc.25572
2015

Combined robotic and open approach to excision of accessory bladder and urethral triplication
Journal of Pediatric Urology
DOI: 10.1016/j.jpurol.2014.11.009
2015

Deconstructing the diagnosis of hemophagocytic lymphohistiocytosis using illustrative cases
Journal of Hematopathology
DOI: 10.1007/s12308-015-0254-3
2015

Intracranial atypical teratoid/rhabdoid tumor presenting as an axillary mass: A case report and review of literature
Pediatric and Developmental Pathology
DOI: 10.2350/14-01-1427-CR.1
2014

Outcomes of persons with blastomycosis involving the central nervous system
Diagnostic Microbiology and Infectious Disease
DOI: 10.1016/j.diagmicrobio.2013.03.002
2013

Research

Eosinophilic Esophagitis including the role of IgG4 and other biomarkers

Sarcoma including the role of SWI/SNF proteins

Osteosarcoma including the role of activated beta-catenin

Research Group Members

Michelle Dittrick, Clinical Research Program Manager