Overview

As site Principle Investigator for the Centre for International Bone Marrow Transplant Research (CIBMTR) group, my interests are focused on co-operative, inter-disciplinary programmes aimed at tackling the varied challenges presented by pediatric oncology and hematology patients.

My background in engineering and current experience as a U.S. Naval Flight Surgeon underlines my interest in human factor analysis and risk management within the practice of medicine. In an effort to reduce risk in health management to its lowest possible level, the naval aviation community's use of the "best practice" process to effectively identify, analyze and eliminate or help control a hazard can successfully be applied to our daily endeavors in medicine and will provide insight and options to our practices.

Publications

Ifosfamide, gemcitabine, and vinorelbine is an effective salvage regimen with excellent stem cell mobilization in relapsed or refractory pediatric Hodgkin lymphoma
Pediatric Blood and Cancer
Marr, K. and Ronsley, R. and Nadel, H. and Douglas, K. and Gershony, S. and Strahlendorf, C. and Davis, J.H. and Deyell, R.J.
DOI: 10.1002/pbc.28167
2020

Immune Reconstitution and Infection Patterns after Early Alemtuzumab and Reduced Intensity Transplantation for Nonmalignant Disorders in Pediatric Patients
Biology of Blood and Marrow Transplantation
Bhatt, S.T. and Bednarski, J.J. and Berg, J. and Trinkaus, K. and Murray, L. and Hayashi, R. and Schulz, G. and Hente, M. and Grimley, M. and Chan, K.W. and Kamani, N. and Jacobsohn, D. and Nieder, M. and Hale, G. and Yu, L. and Adams, R. and Dalal, J. and Pulsipher, M.A. and Haut, P. and Chaudhury, S. and Davis, J. and Jaroscak, J. and Andreansky, M. and Willert, J. and Shenoy, S.
DOI: 10.1016/j.bbmt.2018.10.008
2019

SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery
Blood
DOI: 10.1182/blood-2018-03-840702
10/2018

Outcomes of Measurable Residual Disease in Pediatric Acute Myeloid Leukemia before and after Hematopoietic Stem Cell Transplant: Validation of Difference from Normal Flow Cytometry with Chimerism Studies and Wilms Tumor 1 Gene Expression
Biology of Blood and Marrow Transplantation
DOI: 10.1016/j.bbmt.2018.06.010
10/2018

Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes
JCI insight
Wong, J.C. and Bryant, V. and Lamprecht, T. and Ma, J. and Walsh, M. and Schwartz, J. and Del Pilar Alzamora, M. and Mullighan, C.G. and Loh, M.L. and Ribeiro, R. and Downing, J.R. and Carroll, W.L. and Davis, J. and Gold, S. and Rogers, P.C. and Israels, S. and Yanofsky, R. and Shannon, K. and Klco, J.M.
DOI: 10.1172/jci.insight.121086
2018

Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation
Clinical Immunology
Jacob Rozmus and Rachel McDonald and Shan-Yu Fung and Kate L. Del Bel and Juliana Roden and Christof Senger and Kirk R. Schultz and Margaret L. McKinnon and Jeffrey Davis and Stuart E. Turvey
DOI: 10.1016/j.clim.2016.04.011
07/2016

Health-Related Quality of Life in Survivors of High-Risk Neuroblastoma After Stem Cell Transplant: A National Population-Based Perspective.
Pediatric blood & cancer
DOI: 10.1002/pbc.26063
PubMed: 27203368
05/2016

Hematopoietic Cell Transplantation Using Reduced-Intensity Conditioning Is Successful in Children with Hematologic Cytopenias of Genetic Origin
Biology of Blood and Marrow Transplantation
Alok Kothari and Alexander Ngwube and Robert Hayashi and Lisa Murray and Jeffrey Davis and Paul Haut and Brett J. Loechelt and Shalini Shenoy
DOI: 10.1016/j.bbmt.2015.03.019
07/2015

Haematopoietic stem cell transplantation for refractory Langerhans cell histiocytosis: Outcome by intensity of conditioning
British Journal of Haematology
Veys, P.A. and Nanduri, V. and Baker, K.S. and He, W. and Bandini, G. and Biondi, A. and Dalissier, A. and Davis, J.H. and Eames, G.M. and Egeler, R.M. and Filipovich, A.H. and Fischer, A. and J{\"u}rgens, H. and Krance, R. and Lanino, E. and Leung, W.H. and Matthes, S. and Michel, G. and Orchard, P.J. and Pieczonka, A. and Ringd{\'e}n, O. and Schlegel, P.G. and Sirvent, A. and Vettenranta, K. and Eapen, M.
DOI: 10.1111/bjh.13347
2015

Comparison of outcomes of hematopoietic stem cell transplantation without chemotherapy conditioning by using matched sibling and unrelated donors for treatment of severe combined immunodeficiency
Journal of Allergy and Clinical Immunology
Dvorak, C.C. and Hassan, A. and Slatter, M.A. and H{\"o}nig, M. and Lankester, A.C. and Buckley, R.H. and Pulsipher, M.A. and Davis, J.H. and G{\"u}ng{\"o}r, T. and Gabriel, M. and Bleesing, J.H. and Bunin, N. and Sedlacek, P. and Connelly, J.A. and Crawford, D.F. and Notarangelo, L.D. and Pai, S.-Y. and Hassid, J. and Veys, P. and Gennery, A.R. and Cowan, M.J.
DOI: 10.1016/j.jaci.2014.06.021
2014

Outcomes after Hematopoietic Stem Cell Transplantation for Children with I-Cell Disease
Biology of Blood and Marrow Transplantation
Lund, T.C. and Cathey, S.S. and Miller, W.P. and Eapen, M. and Andreansky, M. and Dvorak, C.C. and Davis, J.H. and Dalal, J.D. and Devine, S.M. and Eames, G.M. and Ferguson, W.S. and Giller, R.H. and He, W. and Kurtzberg, J. and Krance, R. and Katsanis, E. and Lewis, V.A. and Sahdev, I. and Orchard, P.J.
DOI: 10.1016/j.bbmt.2014.06.019
2014

Transplantation outcomes for severe combined immunodeficiency, 2000-2009
New England Journal of Medicine
Pai, S.-Y. and Logan, B.R. and Griffith, L.M. and Buckley, R.H. and Parrott, R.E. and Dvorak, C.C. and Kapoor, N. and Hanson, I.C. and Filipovich, A.H. and Jyonouchi, S. and Sullivan, K.E. and Small, T.N. and Burroughs, L. and Skoda-Smith, S. and Haight, A.E. and Grizzle, A. and Pulsipher, M.A. and Chan, K.W. and Fuleihan, R.L. and Haddad, E. and Loechelt, B. and Aquino, V.M. and Gillio, A. and Davis, J. and Knutsen, A. and Smith, A.R. and Moore, T.B. and Schroeder, M.L. and Goldman, F.D. and Connelly, J.A. and Porteus, M.H. and Xiang, Q. and Shearer, W.T. and Fleisher, T.A. and Kohn, D.B. and Puck, J.M. and Notarangelo, L.D. and Cowan, M.J. and O{'}Reilly, R.J.
DOI: 10.1056/NEJMoa1401177
2014

Outcomes of Allogeneic Hematopoietic cell transplantation in patients with Dyskeratosis Congenita
Biology of Blood and Marrow Transplantation
Gadalla, S.M. and Sales-Bonfim, C. and Carreras, J. and Alter, B.P. and Antin, J.H. and Ayas, M. and Bodhi, P. and Davis, J. and Davies, S.M. and Deconinck, E. and Deeg, H.J. and Duerst, R.E. and Fasth, A. and Ghavamzadeh, A. and Giri, N. and Goldman, F.D. and Kolb, E.A. and Krance, R. and Kurtzberg, J. and Leung, W.H. and Srivastava, A. and Or, R. and Richman, C.M. and Rosenberg, P.S. and Toledo Codina, J.S.D. and Shenoy, S. and Soci{\'e}, G. and Tolar, J. and Williams, K.M. and Eapen, M. and Savage, S.A.
DOI: 10.1016/j.bbmt.2013.05.021
2013

Leukemic transformation of anaplastic large-cell lymphoma
Blood
Vawda, A. and Davis, J. and Vercauteren, S.
DOI: 10.1182/blood-2010-11-318048
2011

Dexmedetomidine for co-analgesia in chemotherapy-induced severe enterocolitis
Paediatric Anaesthesia
Winton, P. and Whyte, E. and Reimer, E.J. and Davis, J. and Whyte, S.
DOI: 10.1111/j.1460-9592.2011.03575.x
2011

Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency
Clinical Immunology
Geoff D.E. Cuvelier and Kirk R. Schultz and Jeff Davis and Aaron F. Hirschfeld and Anne K. Junker and Rusung Tan and Stuart E. Turvey
DOI: 10.1016/j.clim.2009.01.003
05/2009

Allogeneic hematopoietic stem-cell transplantation for leukocyte adhesion deficiency
Pediatrics
Qasim, W. and Cavazzana-Calvo, M. and Davies, E.G. and Davis, J. and Duval, M. and Eames, G. and Farinha, N. and Filopovich, A. and Fischer, A. and Friedrich, W. and Gennery, A. and Heilmann, C. and Landais, P. and Horwitz, M. and Porta, F. and Sedlacek, P. and Seger, R. and Slatten, M. and Teague, L. and Eapen, M. and Veys, P.
DOI: 10.1542/peds.2008-1191
2009

Torticollis as a sign of cervico-thoracic epidural haematoma in an infant with severe haemophilia A
Haemophilia
G. D. E. CUVELIER and J. H. DAVIS and E. C. PURVES and J. K. WU
DOI: 10.1111/j.1365-2516.2006.01323.x
11/2006

DETECTION OF A NOVEL NONSENSE MUTATION IN THE INTERLEUKIN 2 RECEPTOR ¿ GENE CAUSING X-LINKED SEVERE COMBINED IMMUNODEFICIENCY
Annals of Allergy, Asthma & Immunology
Lindsay Cohen and Aaron F. Hirschfeld and Anne K. Junker and Jeff Davis and Stuart E. Turvey
DOI: 10.1016/s1081-1206(10)63563-6
04/2006

Improving patient safety by design — a new spinal/intrathecal injection safety system
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Ian Sheppard and Jeff Davis and Derek Blackstock
DOI: 10.1007/bf03021540
01/2006

Detection of a novel nonsense mutation in the interleukin 2 receptor ¿ gene causing X-linked severe combined immunodeficiency [2]
Annals of Allergy, Asthma and Immunology
Cohen, L. and Hirschfeld, A.F. and Junker, A.K. and Davis, J. and Turvey, S.E.
DOI: 10.1016/S1081-1206(10)63563-6
2006

Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita
Blood
H. Ly
DOI: 10.1182/blood-2005-01-0247
08/2005

Cytomegalovirus prophylaxis and treatment after hematopoietic stem cell transplantation in Canada: A description of current practices and comparison with Centers for Disease Control/Infectious Diseases Society of America/American Society for Blood and Marrow Transplantation guideline recommendations
Biology of Blood and Marrow Transplantation
Fraser, G.A.M. and Walker, I.I. and Russell, J. and Larratt, L. and Davis, J. and Hogge, D. and Voralia, M. and Rubinger, M. and Schroeder, M. and Walker, I. and Doyle, J. and Messner, H. and Berinstein, N. and Howson-Jan, K. and Lopez, P. and Huebsch, I. and Moquin, J.-P. and Roy, J. and Champagne, M. and Laneuville, P. and Mitchell, D. and Lachance, S. and Cantin, G. and Couture, F. and Couban, S. and Duggan, P.
DOI: 10.1016/j.bbmt.2003.10.007
2004

Second malignancy following high-dose therapy and autologous stem cell transplantation: incidence and risk factor analysis
Bone Marrow Transplantation
D L Forrest and T J Nevill and S C Naiman and A Le and D A Brockington and M J Barnett and J C Lavoie and S H Nantel and K W Song and J D Shepherd and H J Sutherland and C L Toze and J H Davis and D E Hogge
DOI: 10.1038/sj.bmt.1704243
10/2003

Non-resectable congenital tumors with theETV6-NTRK3 gene fusion are highly responsive to chemotherapy
Medical and Pediatric Oncology
Emma McCahon and Poul H.B. Sorensen and Jeff H. Davis and Paul C.J. Rogers and Kirk R. Schultz
DOI: 10.1002/mpo.10272
03/2003

Candida dubliniensis Fungemia and Vascular Access Infection
Journal of Pediatric Hematology/Oncology
Nevio Cimolai and Jeff Davis and Colleen Trombley
DOI: 10.1097/00043426-200203000-00017
03/2002

The North American Immune Tolerance Registry: Practices, outcomes, outcome predictors
Thrombosis and Haemostasis
DiMichele, D.M. and Kroner, B.L. and Adair, S. and Addiego, J. and Anderson, V. and Barbosa, J. and Blatt, P. and Bockenstedt, P. and Castle, V. and Chenaille, P. and Cohen, J. and Czapek, E. and Davis, J. and Davignon, G. and De Alarcon, P. and Dubowy, R. and DuCore, J. and Dugdale, M. and Ewenstein, B. and Fahner, J. and Gribble, T.J. and Gnarra, D. and Gruppo, R. and Hakami, N. and Hanna, M. and Hanna, W. and Haut, P. and Heggie, G. and Homans, A. and Hutter, J. and Johnson, C. and Kajani, M. and Karpatkin, M. and Kasper, C. and Katz, J. and Kessler, C. and Key, N. and Koerper, M. and Konkle, B. and Kosinski, R. and Lazerson, J. and Lightsey, A. and Loew, T. and Lusher, J. and MacLaughlin, W. and Manco-Johnson, M. and Manno, C. and McRedmond, K. and Phatak, P. and Powell, J. and Ragni, M. and Rosenfield, C. and Sanders, J. and Santiago-Borrero, P. and Saidi, P. and Seeler, R. and Seremetis, S. and Sexauer, J. and Travis, S. and Valdez, L. and Warner, E. and White, G. and Barrand, D. and Drown, J. and Herst, J. and Inwood, M. and Lillicrap, D. and Rivard, G. and Rubin, S. and Stranczyniski, H. and Teitel, J.
DOI: 10.1055/s-0037-1612943
2002

Efficacy and safety of the factor VIII/von Willebrand factor concentrate, Haemate-P/Humate-P: Ristocetin cofactor unit dosing in patients with von Willebrand disease
Thrombosis and Haemostasis
Lillicrap, D. and Poon, M.-C. and Walker, I. and Xie, F. and Schwartz, B.A. and Akabutu, J. and Ali, K. and Barnard, D. and Blanchette, V. and Bond, M. and Carcao, M. and Card, R. and David, M. and Davis, J. and Delorme, M. and Demers, C. and Dolan, S. and Drouin, J. and Garvey, B. and Gill, K. and Growe, G. and Herst, J. and Israels, S. and Lepine-Martin, M. and Luke, K.-H. and McCusker, P. and Pai, M. and Ritchie, B. and Rivard, G. and Robinson, S. and Ross, E. and Rubin, S. and Rubinger, M. and Scully, M.F. and Silva, M. and St.-Louis, J. and Stobart, K. and Teitel, J. and Vickars, L. and Wu, J.
DOI: 10.1055/s-0037-1612977
2002

High-Dose Melphalan, Etoposide, Total-Body Irradiation, and Autologous Stem-Cell Reconstitution as Consolidation Therapy for High-Risk Ewing’s Sarcoma Does Not Improve Prognosis
Journal of Clinical Oncology
Paul A. Meyers and Mark D. Krailo and Marc Ladanyi and Ka-Wah Chan and Scott L. Sailer and Paul S. Dickman and David L. Baker and Jeffrey H. Davis and Robert B. Gerbing and Alfred Grovas and Cynthia E. Herzog and Karen L. Lindsley and Wen Liu-Mares and James B. Nachman and Lance Sieger and Jean Wadman and Richard G. Gorlick
DOI: 10.1200/jco.2001.19.11.2812
06/2001

Diamond-Blackfan Anemia and Cyclosporine Therapy Revisited
Journal of Pediatric Hematology/Oncology
Angela J. Alessandri and Paul C. Rogers and Louis D. Wadsworth and Jeffrey H. Davis
DOI: 10.1097/00043426-200003000-00020
03/2000

Successful use of cyclosporine A in the treatment of refractory thrombotic thrombocytopenic purpura
British Journal of Haematology
Hand and Lawlor and Yong and Davis
DOI: 10.1046/j.1365-2141.1998.00602.x
03/1998

Causes of death in Canadians with haemophilia 1980-1995
Haemophilia
Walker, I.R. and Julian, J.A. and Growe, G. and Davis, J. and Vickars, L. and Akabutu, J. and Ritchie, B. and Poon, M.-C. and Wu, J. and Card, R. and Ali, K. and Israels, S. and Rubinger, M. and Stobard, K. and Inwood, M. and McCusker, P. and Walker, I. and Pai, M. and Teitel, J. and Garvey, B. and Blanchette, V. and Giles, A. and Lillicrap, D. and Silva, M. and Drouin, J. and Luke, K.-H. and Gill, K. and Herst, J. and Lepine-Martin, M. and Rivard, G. and Bond, M. and David, M. and St.-Louis, J. and Jobin, F. and Demers, C. and Jardine, L. and Scully, M.-F. and Barnard, D. and Robinson, S. and Rubin, S. and Dolan, S. and Ross, E.
DOI: 10.1046/j.1365-2516.1998.00179.x
1998

Immunosuppressive Therapy: A Potential Alternative to Bone Marrow Transplantation as Initial Therapy for Acquired Severe Aplastic Anemia in Childhood?
Journal of Pediatric Hematology/Oncology
Elizabeth R. Lawlor and Ronald A. Anderson and Jeffrey H. Davis and Christopher J. H. Fryer and Sheila L. Pritchard and Paul C. J. Rogers and John K. Wu and Kirk R. Schultz
DOI: 10.1097/00043426-199703000-00004
03/1997

Letters to the editor: Reply
Journal of Pediatric Hematology/Oncology
Lawlor, E.R. and Anderson, R.A. and Davis, J.H. and Fryer, C.J.H. and Pritchard, S.L. and Rogers, P.C.J. and Wu, J.K. and Schultz, K.R.
1997

Erythropoietin therapy in neonates at risk of having bronchopulmonary dysplasia and requiring multiple transfusions
The Journal of Pediatrics
Turki Al-Kharfy and John A. Smyth and Louis Wadsworth and Gerald Krystal and Colleen Fitzgerald and Jeffrey Davis and Ruth Milner
DOI: 10.1016/s0022-3476(96)70194-4
07/1996

Erythropoietin therapy in neonates at risk of having bronchopulmonary dysplasia and requiring multiple transfusions
Journal of Pediatrics
Al-Kharfy, T. and Smyth, J.A. and Wadsworth, L. and Krystal, G. and Fitzgerald, C. and Davis, J. and Milner, R.
DOI: 10.1016/S0022-3476(96)70194-4
1996

Obstructive lung disease in children after allogeneic bone marrow transplantation
Blood
Schultz, K.R. and Green, G.J. and Wensley, D. and Sargent, M.A. and Magee, J.F. and Spinelli, J.J. and Pritchard, S. and Davis, J.H. and Rogers, P.C.J. and Chan, K.W. and Phillips, G.L.
DOI: 10.1182/blood.v84.9.3212.bloodjournal8493212
1994

Infantile choriocarcinoma. Re-examination of a potentially curable entity
Cancer
Deborah A. Belchis and Jeanne Mowry and Jeffrey H. Davis
DOI: 10.1002/1097-0142(19930915)72:63.0.co;2-g
09/1993

Infantile choriocarcinoma. Re-examination of a potentially curable entity
Cancer
Belchis, D.A. and Mowry, J. and Davis, J.H.
DOI: 10.1002/1097-0142(19930915)72:63.0.CO;2-G
1993

Treatment of Malignancy with Unmodified Antibody
Pathology and Immunopathology Research
Christopher C. Badger and Claudio Anasetti and Jeff Davis and Irwin D. Bernstein
DOI: 10.1159/000157067
1987

Research

A study of hematopoietic stem cell transplantation (HSCT) in non-malignant disease using a reduced-intensity preparatory regime with campath-H, fludarabine and malphalan
It is hoped that this study will provide evidence that a preparative regimen consisting of a combination of campath-H, fludarabine and malphalan will maximize host immunosuppression without myeloablation, while being well tolerated and sufficient for engraftment of donor hemopoietic cells when minimally mismatched from the recipient or acquired from unrelated sources. It is postulated that this combination will allow for the gradual transition from recipient chimerism to full donor chimerism with minimal early and delayed toxicity to the recipient. The target is children with non-malignant diseases who are benefited by transplantation and for whom myeloablation is not necessary.

Demonstration of human safety & physician acceptance of a unique spinal injection safety system (SISS)
The inadvertent administration of the wrong drug, by the spinal or epidural route, often with catastrophic results, continues to occur in medical practice. Several Canadian and world reports have demonstrated the tragic consequences in all medical fields utilizing spinal therapies, including oncology, anaesthesiology, and obstetrics. Specific recent cases of death as a result of the maladministration of vinca alkaloids into the spine have been reported widely. We have redesigned the spinal needle and system around intrathecal administration of medications and in this study we propose to implement the spinal injection safety system (SISS) in clinical practice. Through evaluating the SISS we will determine its safety attributes for pediatric patients receiving spinal chemotherapy and whether or not it meets the practice expectations of physicians. We also seek to significantly reduce the net risk of patient harm through inadvertent human error during the spinal drug administration procedure as well as be cost-effective in comparison to current practices.

Honours & Awards

Bruce W Jackson Memorial Award for the Reserve Flight Surgeon of the Year, The Society of United States Naval Flight Surgeons - 2014

Rookie of the Year Attending Award, University of British Columbia Residents - 1992