As site Principle Investigator for the Centre for International Bone Marrow Transplant Research (CIBMTR) group, my interests are focused on co-operative, inter-disciplinary programmes aimed at tackling the varied challenges presented by pediatric oncology and hematology patients.
My background in engineering and current experience as a U.S. Naval Flight Surgeon underlines my interest in human factor analysis and risk management within the practice of medicine. In an effort to reduce risk in health management to its lowest possible level, the naval aviation community's use of the "best practice" process to effectively identify, analyze and eliminate or help control a hazard can successfully be applied to our daily endeavors in medicine and will provide insight and options to our practices.
Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation Clinical Immunology Jacob Rozmus and Rachel McDonald and Shan-Yu Fung and Kate L. Del Bel and Juliana Roden and Christof Senger and Kirk R. Schultz and Margaret L. McKinnon and Jeffrey Davis and Stuart E. Turvey DOI: 10.1016/j.clim.2016.04.011 07/2016
Hematopoietic Cell Transplantation Using Reduced-Intensity Conditioning Is Successful in Children with Hematologic Cytopenias of Genetic Origin Biology of Blood and Marrow Transplantation Alok Kothari and Alexander Ngwube and Robert Hayashi and Lisa Murray and Jeffrey Davis and Paul Haut and Brett J. Loechelt and Shalini Shenoy DOI: 10.1016/j.bbmt.2015.03.019 07/2015
Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency Clinical Immunology Geoff D.E. Cuvelier and Kirk R. Schultz and Jeff Davis and Aaron F. Hirschfeld and Anne K. Junker and Rusung Tan and Stuart E. Turvey DOI: 10.1016/j.clim.2009.01.003 05/2009
Torticollis as a sign of cervico-thoracic epidural haematoma in an infant with severe haemophilia A Haemophilia G. D. E. CUVELIER and J. H. DAVIS and E. C. PURVES and J. K. WU DOI: 10.1111/j.1365-2516.2006.01323.x 11/2006
Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita Blood H. Ly DOI: 10.1182/blood-2005-01-0247 08/2005
Second malignancy following high-dose therapy and autologous stem cell transplantation: incidence and risk factor analysis Bone Marrow Transplantation D L Forrest and T J Nevill and S C Naiman and A Le and D A Brockington and M J Barnett and J C Lavoie and S H Nantel and K W Song and J D Shepherd and H J Sutherland and C L Toze and J H Davis and D E Hogge DOI: 10.1038/sj.bmt.1704243 10/2003
Non-resectable congenital tumors with theETV6-NTRK3 gene fusion are highly responsive to chemotherapy Medical and Pediatric Oncology Emma McCahon and Poul H.B. Sorensen and Jeff H. Davis and Paul C.J. Rogers and Kirk R. Schultz DOI: 10.1002/mpo.10272 03/2003
High-Dose Melphalan, Etoposide, Total-Body Irradiation, and Autologous Stem-Cell Reconstitution as Consolidation Therapy for High-Risk Ewing’s Sarcoma Does Not Improve Prognosis Journal of Clinical Oncology Paul A. Meyers and Mark D. Krailo and Marc Ladanyi and Ka-Wah Chan and Scott L. Sailer and Paul S. Dickman and David L. Baker and Jeffrey H. Davis and Robert B. Gerbing and Alfred Grovas and Cynthia E. Herzog and Karen L. Lindsley and Wen Liu-Mares and James B. Nachman and Lance Sieger and Jean Wadman and Richard G. Gorlick DOI: 10.1200/jco.2001.19.11.2812 06/2001
Immunosuppressive Therapy: A Potential Alternative to Bone Marrow Transplantation as Initial Therapy for Acquired Severe Aplastic Anemia in Childhood? Journal of Pediatric Hematology/Oncology Elizabeth R. Lawlor and Ronald A. Anderson and Jeffrey H. Davis and Christopher J. H. Fryer and Sheila L. Pritchard and Paul C. J. Rogers and John K. Wu and Kirk R. Schultz DOI: 10.1097/00043426-199703000-00004 03/1997
Erythropoietin therapy in neonates at risk of having bronchopulmonary dysplasia and requiring multiple transfusions The Journal of Pediatrics Turki Al-Kharfy and John A. Smyth and Louis Wadsworth and Gerald Krystal and Colleen Fitzgerald and Jeffrey Davis and Ruth Milner DOI: 10.1016/s0022-3476(96)70194-4 07/1996
A study of hematopoietic stem cell transplantation (HSCT) in non-malignant disease using a reduced-intensity preparatory regime with campath-H, fludarabine and malphalan It is hoped that this study will provide evidence that a preparative regimen consisting of a combination of campath-H, fludarabine and malphalan will maximize host immunosuppression without myeloablation, while being well tolerated and sufficient for engraftment of donor hemopoietic cells when minimally mismatched from the recipient or acquired from unrelated sources. It is postulated that this combination will allow for the gradual transition from recipient chimerism to full donor chimerism with minimal early and delayed toxicity to the recipient. The target is children with non-malignant diseases who are benefited by transplantation and for whom myeloablation is not necessary.
Demonstration of human safety & physician acceptance of a unique spinal injection safety system (SISS) The inadvertent administration of the wrong drug, by the spinal or epidural route, often with catastrophic results, continues to occur in medical practice. Several Canadian and world reports have demonstrated the tragic consequences in all medical fields utilizing spinal therapies, including oncology, anaesthesiology, and obstetrics. Specific recent cases of death as a result of the maladministration of vinca alkaloids into the spine have been reported widely. We have redesigned the spinal needle and system around intrathecal administration of medications and in this study we propose to implement the spinal injection safety system (SISS) in clinical practice. Through evaluating the SISS we will determine its safety attributes for pediatric patients receiving spinal chemotherapy and whether or not it meets the practice expectations of physicians. We also seek to significantly reduce the net risk of patient harm through inadvertent human error during the spinal drug administration procedure as well as be cost-effective in comparison to current practices.
Honours & Awards
Bruce W Jackson Memorial Award for the Reserve Flight Surgeon of the Year, The Society of United States Naval Flight Surgeons - 2014
Rookie of the Year Attending Award, University of British Columbia Residents - 1992
Human DNA testing could improve outcomes for patients with COVID-19.
That’s the key idea put forth in preliminary research posted this month to bioRxiv that highlights the potential benefits of testing COVID-19 patients for genetic variants of ACE2—the protein identified as the point-of-entry for the SARS-COV-2 virus into human cells.
Congratulations to the BC Children's and BC Women's investigators who were awarded funding through the highly competitive Canadian Institutes of Health Research (CIHR) Project Grant Fall 2019 competition.
A new study suggests that specialized immune cells that dampen inflammation and help repair the gut could be used as a potential therapy for children dealing with the painful symptoms of inflammatory bowel disease.
We believe there’s nothing we can’t do with your support. It can take years to turn scientific breakthrough into new interventions and treatments. Funding helps speed the pace of change. When given the resources, we can bring transformative therapies – and hope – out of the laboratory and into the clinic to save and improve children’s lives.