Publications

Re-Irradiation in patients with Diffuse Intrinsic Pontine Gliomas: The Canadian Experience
Pediatric Blood & Cancer
Lassaletta, Alvaro and Strother, Douglas and Laperriere, Normand and Hukin, Juliette and Vanan, Magimairajan Issai and Goddard, Karen and Lafay-Cousin, Lucie and Johnston, Donna L. and Zelcer, Shayna and Zapotocky, Michal and Rajagopal, Revathi and Ramaswamy, Vijay and Hawkins, Cynthia and Tabori, Uri and Huang, Annie and Bartels, Ute and Bouffet, Eric
DOI: 10.1002/pbc.26988
01/2018

Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome.
Acta neuropathologica
Panwalkar P and Clark J and Ramaswamy V and Hawes D and Yang F and Dunham C and Yip S and Hukin J and Sun Y and Schipper MJ and Chavez L and Margol A and Pekmezci M and Chung C and Banda A and Venneti S
DOI: 10.1007/s00401-017-1752-4
PubMed: 28733933
11/2017

Opsoclonus-Myoclonus Syndrome: A New Era of Improved Prognosis?
Pediatric Neurology
Armine Galstyan and Colin Wilbur and Kathryn Selby and Juliette Hukin
DOI: 10.1016/j.pediatrneurol.2017.03.011
07/2017

Determinants of social competence in pediatric brain tumor survivors who participated in an intervention study
Supportive Care in Cancer
Maru Barrera and Eshetu G. Atenafu and Fiona Schulte and Ute Bartels and Lillian Sung and Laura Janzen and Joanna Chung and Danielle Cataudella and Kelly Hancock and Amani Saleh and Douglas Strother and Dina McConnell and Andrea Downie and Juliette Hukin and Shayna Zelcer
DOI: 10.1007/s00520-017-3708-6
04/2017

Determinants of quality of life outcomes for survivors of pediatric brain tumors
Pediatric Blood & Cancer
Maru Barrera and Eshetu G. Atenafu and Fiona Schulte and Ute Bartels and Lillian Sung and Laura Janzen and Joanna Chung and Danielle Cataudella and Kelly Hancock and Amani Saleh and Douglas Strother and Dina McConnell and Andrea Downie and Juliette Hukin and Shayna Zelcer
DOI: 10.1002/pbc.26481
03/2017

Atypical teratoid rhabdoid tumor in the first year of life: the Canadian ATRT registry experience and review of the literature.
Journal of neuro-oncology
Fossey M and Li H and Afzal S and Carret AS and Eisenstat DD and Fleming A and Hukin J and Hawkins C and Jabado N and Johnston D and Brown T and Larouche V and Scheinemann K and Lafay-Cousin L
DOI: 10.1007/s11060-016-2353-0
PubMed: 28102486
03/2017

A randomized control intervention trial to improve social skills and quality of life in pediatric brain tumor survivors
Psycho-Oncology
Maru Barrera and Eshetu G. Atenafu and Lillian Sung and Ute Bartels and Fiona Schulte and Joanna Chung and Danielle Cataudella and Kelly Hancock and Laura Janzen and Amani Saleh and Douglas Strother and Andrea Downie and Shayna Zelcer and Juliette Hukin and Dina McConnell
DOI: 10.1002/pon.4385
2017

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.
Cancer cell
Torchia J and Golbourn B and Feng S and Ho KC and Sin-Chan P and Vasiljevic A and Norman JD and Guilhamon P and Garzia L and Agamez NR and Lu M and Chan TS and Picard D and Huang A
DOI: 10.1016/j.ccell.2016.11.003
PubMed: 27960086
12/2016

Phase II Weekly Vinblastine for Chemotherapy-Naïve Children With Progressive Low-Grade Glioma: A Canadian Pediatric Brain Tumor Consortium Study
Journal of Clinical Oncology
Alvaro Lassaletta and Katrin Scheinemann and Shayna M. Zelcer and Juliette Hukin and Beverley A. Wilson and Nada Jabado and Anne Sophie Carret and Lucie Lafay-Cousin and Valerie Larouche and Cynthia E. Hawkins and Gregory Russell Pond and Ken Poskitt and Daniel Keene and Donna L. Johnston and David D. Eisenstat and Rahul Krishnatry and Matthew Mistry and Anthony Arnoldo and Vijay Ramaswamy and Annie Huang and Ute Bartels and Uri Tabori and Eric Bouffet
DOI: 10.1200/jco.2016.68.1585
10/2016

Episodic ataxia associated with a de novo SCN2A mutation
European Journal of Paediatric Neurology
Emma L. Leach and Clara D.M. van Karnebeek and Katelin N. Townsend and Maja Tarailo-Graovac and Juliette Hukin and William T. Gibson
DOI: 10.1016/j.ejpn.2016.05.020
09/2016

Targeted detection of genetic alterations reveal the prognostic impact of H3K27M and MAPK pathway aberrations in paediatric thalamic glioma
Acta Neuropathologica Communications
Scott Ryall and Rahul Krishnatry and Anthony Arnoldo and Pawel Buczkowicz and Matthew Mistry and Robert Siddaway and Cino Ling and Sanja Pajovic and Man Yu and Joshua B. Rubin and Juliette Hukin and Paul Steinbok and Ute Bartels and Eric Bouffet and Uri Tabori and Cynthia Hawkins
DOI: 10.1186/s40478-016-0353-0
08/2016

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Ramaswamy V and Hielscher T and Mack SC and Lassaletta A and Lin T and Pajtler KW and Jones DT and Luu B and Cavalli FM and Aldape K and Remke M and Mynarek M and Rutkowski S and Taylor MD
DOI: 10.1200/jco.2015.65.7825
PubMed: 27269943
07/2016

Ophthalmological outcomes of patients treated for pineal region tumors
Journal of Neurosurgery: Pediatrics
Elizabeth V. Hankinson and Christopher J. Lyons and Juliette Hukin and David D. Cochrane
DOI: 10.3171/2015.10.peds15415
05/2016

Eye Findings on Vigabatrin and Taurine Treatment in Two Patients with Succinic Semialdehyde Dehydrogenase Deficiency
Neuropediatrics
Juliette Hukin and Sylvia Stockler-Ipsiroglu and Maryam Aroichane and Gabriella-Ana Horvath
DOI: 10.1055/s-0036-1583183
04/2016

White matter and information processing speed following treatment with cranial-spinal radiation for pediatric brain tumor.
Neuropsychology
Nadia Scantlebury and Eric Bouffet and Suzanne Laughlin and Douglas Strother and Dina McConnell and Juliette Hukin and Christopher Fryer and Normand Laperriere and Isabelle Montour-Proulx and Daniel Keene and Adam Fleming and Nada Jabado and Fang Liu and Lily Riggs and Nicole Law and Donald J. Mabbott
DOI: 10.1037/neu0000258
2016

Longitudinal Outcomes in the 2014 Acute Flaccid Paralysis Cluster in Canada
Journal of Child Neurology
Carmen Yea and Ari Bitnun and Joan Robinson and Aleksandra Mineyko and Michelle Barton and Jean K. Mah and Jiri Vajsar and Susan Richardson and Christoph Licht and Jason Brophy and Megan Crone and Shalini Desai and Juliette Hukin and Kevin Jones and Katherine Muir and Jeffrey M. Pernica and Robert Pless and Daniela Pohl and Mubeen F. Rafay and Kathryn Selby and Sunita Venkateswaran and Geneviève Bernard and E. Ann Yeh
DOI: 10.1177/0883073816680770
2016

Pediatric thalamic tumors in the MRI era: a Canadian perspective
Child's Nervous System
Paul Steinbok and Chittur Viswanathan Gopalakrishnan and Alexander R. Hengel and Aleksander M. Vitali and Ken Poskitt and Cynthia Hawkins and James Drake and Maria Lamberti-Pasculli and Olufemi Ajani and Walter Hader and Vivek Mehta and P. Daniel McNeely and Patrick J. McDonald and Adrianna Ranger and Michael Vassilyadi and Jeff Atkinson and Scott Ryall and David D. Eisenstat and Juliette Hukin
DOI: 10.1007/s00381-015-2968-z
11/2015

Assessing the accuracy of death records and pre-mortem clinical diagnoses in children diagnosed with brain tumors: A retrospective chart review of children in British Columbia, Canada
Pathology - Research and Practice
Haroon Hasan and Glenda Hendson and A. Fuchsia Howard and Juliette Hukin and Christopher Dunham and Tareq Ahmed and Andrea C. Lo and Karen Goddard
DOI: 10.1016/j.prp.2015.06.008
10/2015

Intracystic interferon-a treatment leads to neurotoxicity in craniopharyngioma: case report
Journal of Neurosurgery: Pediatrics
Julia Sharma and Christopher M. Bonfield and Ash Singhal and Juliette Hukin and Paul Steinbok
DOI: 10.3171/2015.2.peds14656
09/2015

Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis.
The Lancet. Oncology
Torchia J and Picard D and Lafay-Cousin L and Hawkins CE and Kim SK and Letourneau L and Ra YS and Ho KC and Chan TS and Sin-Chan P and Dunham CP and Yip S and Ng HK and Lu JQ and Albrecht S and Huang A
DOI: 10.1016/s1470-2045(15)70114-2
PubMed: 25882982
05/2015

AT-07 * SUCCESSFUL TREATMENT OF ATRT PATIENTS WITHOUT ADJUVANT RADIATION: A MULTI INSTITUTIONAL CANADIAN EXPERIENCE
Neuro-Oncology
D. Ku and L. Lafay-Cousin and C. Fryer and J. Hukin and D. Strother and A. Huang and E. Bouffet
DOI: 10.1093/neuonc/nov061.6
04/2015

Neurocognitive evaluation of long term survivors of atypical teratoid rhabdoid tumors (ATRT): The Canadian registry experience
Pediatric Blood & Cancer
Lucie Lafay-Cousin and Taryn Fay-McClymont and Donna Johnston and Chris Fryer and Katrin Scheinemann and Adam Fleming and Juliette Hukin and Laura Janzen and Sharon Guger and Douglas Strother and Donald Mabbott and Annie Huang and Eric Bouffet
DOI: 10.1002/pbc.25441
03/2015

EZH2 expression is a prognostic factor in childhood intracranial ependymoma: A Canadian Pediatric Brain Tumor Consortium study
Cancer
Amanda M. Li and Christopher Dunham and Uri Tabori and Anne-Sophie Carret and P. Daniel McNeely and Donna Johnston and Lucie Lafay-Cousin and Beverly Wilson and David D. Eisenstat and Nada Jabado and Shayna Zelcer and Mariana Silva and Katrin Scheinemann and Christopher Fryer and Glenda Hendson and Abbas Fotovati and Cynthia Hawkins and Stephen Yip and Sandra E. Dunn and Juliette Hukin
DOI: 10.1002/cncr.29198
01/2015

Low Grade Glioma
Pediatric Neuro-oncology
Katrin Scheinemann and Juliette Hukin
DOI: 10.1007/978-1-4939-1541-5_9
2015

Ependymoma
Pediatric Neuro-oncology
Juliette Hukin and John-Paul Kilday and Uri Tabori
DOI: 10.1007/978-1-4939-1541-5_13
2015

The role of resection alone in select children with intracranial ependymoma: the Canadian Pediatric Brain Tumour Consortium experience
Child's Nervous System
Tamir Ailon and Christopher Dunham and Anne-Sophie Carret and Uri Tabori and P. Daniel Mcneely and Shayna Zelcer and Beverley Wilson and Lucie Lafay-Cousin and Donna Johnston and David D. Eisenstat and Marianna Silva and Nada Jabado and Karen Jane Goddard and Chris Fryer and Glenda Hendson and Cynthia Hawkins and Sandra Dunn and Stephen Yip and Ashutosh Singhal and Juliette Hukin
DOI: 10.1007/s00381-014-2575-4
11/2014

White matter compromise predicts poor intellectual outcome in survivors of pediatric low-grade glioma
Neuro-Oncology
F. Liu and N. Scantlebury and U. Tabori and E. Bouffet and S. Laughlin and D. Strother and D. McConnell and J. Hukin and C. Fryer and M.-E. Briere and I. Montour-Proulx and D. Keene and F. Wang and D. J. Mabbott
DOI: 10.1093/neuonc/nou306
11/2014

Epidemiology of malignant pontine gliomas (MPG) in the paediatric population in Canada: A study of the Canadian paediatric brain tumour consortium (CPBTC)
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Samina Afzal and Anne-Sophie Carret and Adam Fleming and Valerie Larouche and Shayna Zelcer and Donna L. Johnston and Maria Kostova and Chris Mpofu and Douglas Strother and Lucie Lafay-Cousin and David Eisenstat and Chris Fryer and Juliette Hukin and Ute Bartels and Eric Bouffet
DOI: 10.1017/cjn.2014.86
10/2014

Pleomorphic xanthoastrocytoma of the spinal cord: case report and literature review
Clinical Neuropathology
Sumit Das and Stephen Yip and Juliette Hukin and Douglas Cochrane and Christopher Dunham
DOI: 10.5414/np300689
05/2014

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations.
Nature genetics
Buczkowicz P and Hoeman C and Rakopoulos P and Pajovic S and Letourneau L and Dzamba M and Morrison A and Lewis P and Bouffet E and Bartels U and Zuccaro J and Agnihotri S and Ryall S and Hawkins C
DOI: 10.1038/ng.2936
PubMed: 24705254
05/2014

Late effects in survivors of childhood CNS tumors treated on Head Start I and II protocols
Pediatric Blood & Cancer
Aniket Saha and Christina G. Salley and Preeti Saigal and Linda Rolnitzky and Judith Goldberg and Suzanne Scott and Randal Olshefski and Juliette Hukin and Stephen A. Sands and Jonathan Finlay and Sharon L. Gardner
DOI: 10.1002/pbc.25064
05/2014

Multimodality therapy for CNS mixed malignant germ cell tumors (MMGCT): results of a phase II multi-institutional study
Journal of Neuro-Oncology
Patricia L. Robertson and Regina Jakacki and Juliette Hukin and Joao Siffert and Jeffrey C. Allen
DOI: 10.1007/s11060-013-1306-0
04/2014

De-escalation of therapy for pediatric medulloblastoma: Trade-offs between quality of life and survival
Pediatric Blood & Cancer
Natalie Henrich and Carlo A. Marra and Louise Gastonguay and Donald Mabbott and David Malkin and Chris Fryer and Eric Bouffet and Michael D. Taylor and Juliette Hukin and Nadia Scantlebury and Larry Lynd
DOI: 10.1002/pbc.24990
02/2014

Changes to Memory Structures in Children Treated for Posterior Fossa Tumors
Journal of the International Neuropsychological Society
Lily Riggs and Eric Bouffet and Suzanne Laughlin and Normand Laperriere and Fang Liu and Jovanka Skocic and Nadia Scantlebury and Frank Wang and Nicholas J. Schoenhoff and Douglas Strother and Juliette Hukin and Christopher Fryer and Dina McConnell and Donald J. Mabbott
DOI: 10.1017/s135561771300129x
01/2014

Chemotherapy for Tumors
Nervous System of Children
2014

Growing teratoma syndrome in intracranial non-germinomatous germ cell tumors (iNGGCTs): a risk for secondary malignant transformation—a report of two cases
Child's Nervous System
Torin Glass and D. Douglas Cochrane and Shahrad Rod Rassekh and Karen Goddard and Juliette Hukin
DOI: 10.1007/s00381-013-2295-1
10/2013

Optic pathway gliomas in adolescence--time to challenge treatment choices?
Neuro-Oncology
A. Lee Chong and J. D. Pole and K. Scheinemann and J. Hukin and U. Tabori and A. Huang and E. Bouffet and U. Bartels
DOI: 10.1093/neuonc/nos312
01/2013

Novel Mutations in FA2H-Associated Neurodegeneration
Journal of Child Neurology
Rosemarie Rupps and Juliette Hukin and Martha Balicki and Saadet Mercimek-Mahmutoglu and Arndt Rolfs and Cristina Dias
DOI: 10.1177/0883073812458538
09/2012

Clinical and neuroanatomical predictors of cerebellar mutism syndrome
Neuro-Oncology
N. Law and M. Greenberg and E. Bouffet and M. D. Taylor and S. Laughlin and D. Strother and C. Fryer and D. McConnell and J. Hukin and C. Kaise and F. Wang and D. J. Mabbott
DOI: 10.1093/neuonc/nos160
09/2012

Phase II Study of Weekly Vinblastine in Recurrent or Refractory Pediatric Low-Grade Glioma
Journal of Clinical Oncology
Eric Bouffet and Regina Jakacki and Stewart Goldman and Darren Hargrave and Cynthia Hawkins and Manohar Shroff and Juliette Hukin and Ute Bartels and Nicholas Foreman and Stewart Kellie and Joanne Hilden and Michael Etzl and Beverly Wilson and Derek Stephens and Uri Tabori and Sylvain Baruchel
DOI: 10.1200/jco.2011.34.5843
04/2012

Intracranial tumors in infants: long-term functional outcome, survival, and its predictors
Child's Nervous System
Shibu Pillai and Mary Metrie and Christopher Dunham and Michael Sargent and Juliette Hukin and Paul Steinbok
DOI: 10.1007/s00381-012-1707-y
02/2012

Atypical Teratoid Rhabdoid Tumors (ATRTs): The British Columbia's Children's Hospital's Experience, 1986-2006
Brain Pathology
Adam J. Fleming and Juliette Hukin and Rod Rassekh and Christopher Fryer and James Kim and Anat Stemmer-Rachamimov and Diane K. Birks and Annie Huang and Stephen Yip and Christopher Dunham
DOI: 10.1111/j.1750-3639.2011.00561.x
02/2012

Cystic Craniopharyngiomas: Intratumoral Bleomycin Therapy
Tumors of the Central Nervous System, Volume 8
Paul Steinbok and Juliette Hukin
DOI: 10.1007/978-94-007-4213-0_23
2012

Supratentorial Primitive Neuroectodermal Tumors
Tumors of the Central Nervous System, Volume 4
Mohit Singh and Juliette Hukin
DOI: 10.1007/978-94-007-1706-0_2
08/2011

Cerebello–thalamo–cerebral connections in pediatric brain tumor patients: Impact on working memory
NeuroImage
Nicole Law and Eric Bouffet and Suzanne Laughlin and Normand Laperriere and Marie-Eve Brière and Douglas Strother and Dina McConnell and Juliette Hukin and Christopher Fryer and Conrad Rockel and Jolynn Dickson and Donald Mabbott
DOI: 10.1016/j.neuroimage.2011.03.065
06/2011

The use and effectiveness of temozolomide in children with central nervous system tumours: a survey from the Canadian Paediatric Brain Tumour Consortium
Current Oncology
U. Bartels and S. Baruchel and A.S. Carret and B. Crooks and J. Hukin and D. Johnston and M. Silva and D. Strother and B. Wilson and S. Zelcer and D. Eisenstat and L. Sung and E. Bouffet
DOI: 10.3747/co.v18i1.675
02/2011

Childhood CNS Pediatric Primitive Neuroectodermal Tumors
Tumors of the Central Nervous System
11/2010

Intracystic treatments for craniopharyngioma
Neurosurgical Focus
Paul Steinbok and Juliette Hukin
DOI: 10.3171/2010.1.focus09315
04/2010

Late mortality in pediatric patients with craniopharyngioma
Journal of Neuro-Oncology
Johannes Visser and Juliette Hukin and Michael Sargent and Paul Steinbok and Karen Goddard and Chris Fryer
DOI: 10.1007/s11060-010-0145-5
03/2010

A multi-centre Canadian pilot study of metronomic temozolomide combined with radiotherapy for newly diagnosed paediatric brainstem glioma
European Journal of Cancer
Julia R. Sharp and Eric Bouffet and Diana Stempak and Janet Gammon and Derek Stephens and Donna L. Johnston and David Eisenstat and Juliette Hukin and Yvan Samson and Ute Bartels and Uri Tabori and Annie Huang and Sylvain Baruchel
DOI: 10.1016/j.ejca.2010.06.115
2010

A Canadian paediatric brain tumour consortium (CPBTC) phase II molecularly targeted study of imatinib in recurrent and refractory paediatric central nervous system tumours
European Journal of Cancer
Sylvain Baruchel and Julia R. Sharp and Ute Bartels and Juliette Hukin and Isaac Odame and Carol Portwine and Doug Strother and Chris Fryer and Jackie Halton and Merrill J. Egorin and Rui Manuel Reis and Olga Martinho and Diana Stempak and Cynthia Hawkins and Janet Gammon and Eric Bouffet
DOI: 10.1016/j.ejca.2009.05.008
09/2009

Occurrence of Basal Ganglia Germ Cell Tumors Without a Mass
Archives of Neurology
Salah Almubarak and Yee-Chiung Gan and Paul Steinbok and Glenda Hendson and Ken Poskitt and Helen Nadel and Karen Goddard and Juliette Hukin
DOI: 10.1001/archneurol.2009.74
06/2009

Atypical Presentation of Basal Ganglia Germ Cell Tumors in Children
Journal of Neurosurgery: Pediatrics
Paul Steinbok and Salah Almubarak and Peter Gan and Glenda Hendson and Kenneth Poskitt and Helen Nadel and Karen Goddard and Juliette Hukin
DOI: 10.3171/ped/2008/1/4/paper11
04/2008

Intensive chemotherapy followed by consolidative myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) in young children with newly diagnosed supratentorial primitive neuroectodermal tumors (sPNETs): Report of the Head Start I and II experience
Pediatric Blood & Cancer
Jason Fangusaro and Jonathan Finlay and Richard Sposto and Lingyun Ji and Monirath Saly and Stergios Zacharoulis and Shahab Asgharzadeh and Minnie Abromowitch and Randal Olshefski and Steven Halpern and Ronald Dubowy and Melanie Comito and Blanca Diez and Stewart Kellie and Juliette Hukin and Marc Rosenblum and Ira Dunkel and Douglas C. Miller and Jeffrey Allen and Sharon Gardner
DOI: 10.1002/pbc.21307
02/2008

Carboplatin hypersensitivity reaction in pediatric patients with low-grade glioma
Cancer
Lucie Lafay-Cousin and Lillian Sung and Anne-Sophie Carret and Juliette Hukin and Beverly Wilson and Donna L. Johnston and Shayna Zelcer and Mariana Silva and Isaac Odame and Chris Mpofu and Douglas Strother and Eric Bouffet
DOI: 10.1002/cncr.23249
2008

Isolated sulfite oxidase deficiency in the newborn: lactic acidaemia and leukoencephalopathy.
Neuropediatrics
Basheer SN and Waters PJ and Lam CW and Acquaviva-Bourdain C and Hendson G and Poskitt K and Hukin J
DOI: 10.1055/s-2007-981484
PubMed: 17607604
02/2007

Intracystic bleomycin therapy for craniopharyngioma in children
Cancer
Juliette Hukin and Paul Steinbok and Lucie Lafay-Cousin and Glenda Hendson and Douglas Strother and Claude Mercier and Yvan Samson and William Howes and Eric Bouffet
DOI: 10.1002/cncr.22633
2007

Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue
Pediatric Blood & Cancer
Stergios Zacharoulis and Adam Levy and Susan N. Chi and Sharon Gardner and Marc Rosenblum and Douglas C. Miller and Ira Dunkel and Blanca Diez and Richard Sposto and Lingyun Ji and Shahab Asgharzadeh and Juliette Hukin and Jean Belasco and Ronald Dubowy and Stewart Kellie and Amanda Termuhlen and Jonathan Finlay
DOI: 10.1002/pbc.20935
2007

Concurrent carbogen and radiation therapy in children with high-risk brainstem gliomas
Pediatric Blood & Cancer
C. Aquino-Parsons and J. Hukin and A. Green
DOI: 10.1002/pbc.21057
2007

Outcome of secondary high-grade glioma in children previously treated for a malignant condition: A study of the Canadian Pediatric Brain Tumour Consortium
Radiotherapy and Oncology
Anne-Sophie Carret and Uri Tabori and Bruce Crooks and Juliette Hukin and Isaac Odame and Donna L. Johnston and Daniel L. Keene and Carolyn Freeman and Eric Bouffet
DOI: 10.1016/j.radonc.2006.08.005
10/2006

Distinctive clinical course and pattern of relapse in adolescents with medulloblastoma
International Journal of Radiation Oncology*Biology*Physics
Uri Tabori and Lillian Sung and Juliette Hukin and Normand Laperriere and Bruce Crooks and Anne-Sophie Carret and Mariana Silva and Isaac Odame and Chris Mpofu and Douglas Strother and Beverly Wilson and Yvan Samson and Eric Bouffet
DOI: 10.1016/j.ijrobp.2005.07.962
02/2006

The causes and timing of death of craniopharyngiomas patients diagnosed before the age of 17 years
Pediatric Blood & Cancer
10/2005

Asynchronous burst-suppression in a child with callosal Ki-1 anaplastic large cell lymphoma.
Neurology
Hukin J and Davey A and Wong P and Hendson G and Aquino-Parsons C and Wu J and Sargent M
DOI: 10.1212/01.wnl.0000176070.34107.f6
PubMed: 16186544
09/2005

Childhood craniopharyngioma: Vancouver experience
Child's Nervous System
Juliette Hukin and Johann Visser and Michael Sargent and Karen Goddard and Chris Fryer and Paul Steinbok
DOI: 10.1007/s00381-005-1220-7
06/2005

Medulloblastoma in the second decade of life: A specific group with respect to toxicity and management
Cancer
Uri Tabori and Lillian Sung and Juliette Hukin and Normand Laperriere and Bruce Crooks and Anne-Sophie Carret and Mariana Silva and Isaac Odame and Chris Mpofu and Douglas Strother and Beverly Wilson and Yvan Samson and Eric Bouffet and Canadian Pediatric Brain Tumor Consortium
DOI: 10.1002/cncr.21003
2005

Malaysian Siblings with Friedreich Ataxia and Chorea: A Novel Deletion in the Frataxin Gene
The Canadian Journal of Neurological Sciences
Siân D. Spacey and Blazej I. Szczygielski and Sean P. Young and Juliette Hukin and Kathy Selby and Terrance P. Snutch
DOI: 10.1017/s0317167100003498
08/2004

Leptomeningeal dissemination at diagnosis of pediatric low-gradeneuroepithelial tumors
Neuro-Oncology
Juliette Hukin and Joao Siffert and Henry Cohen and Linda Velasquez and David Zagzag and Jeffrey Allen
DOI: 10.1215/s1152851702000297
07/2003

Leptomeningeal dissemination in children with progressive low-grade neuroepithelial tumors
Neuro-Oncology
Juliette Hukin and Joao Siffert and Linda Velasquez and David Zagzag and Jeffrey Allen
DOI: 10.1215/s1522851701000680
10/2002

Tenascin-C promotes microvascular cell migration and phosphorylation of focal adhesion kinase.
Cancer research
Zagzag D and Shiff B and Jallo GI and Greco MA and Blanco C and Cohen H and Hukin J and Allen JC and Friedlander DR
PubMed: 11980665
05/2002

Hyperbaric oxygen therapy for cerebral palsy: two complications of treatment.
Pediatrics
Nuthall G and Seear M and Lepawsky M and Wensley D and Skippen P and Hukin J
DOI: 10.1542/peds.106.6.e80
PubMed: 11099623
12/2000

Intratumoral Therapy with Bleomycin for Cystic Craniopharyngiomas in Children
Pediatric Neurosurgery
Walter J. Hader and Paul Steinbok and Juliette Hukin and Chris Fryer
DOI: 10.1159/000055955
2000

Brain Tumours
Primary Pediatric Care, 4th Edition
03/1999

Encephalopathy complicating Henoch-Schönlein purpura: reversible MRI changes.
Pediatric neurology
Woolfenden AR and Hukin J and Poskitt KJ and Connolly MB
DOI: 10.1016/s0887-8994(98)00027-7
PubMed: 9682892
07/1998

Case-control study of primary human herpesvirus 6 infection in children with febrile seizures.
Pediatrics
Hukin J and Farrell K and MacWilliam LM and Colbourne M and Waida E and Tan R and Mroz L and Thomas E
DOI: 10.1542/peds.101.2.e3
PubMed: 9445513
02/1998

Treatment of Intracranial Ependymoma by Surgery Alone
Pediatric Neurosurgery
Juliette Hukin and Fred Epstein and Dan Lefton and Jeffrey Allen
DOI: 10.1159/000028683
1998

Clinical Manifestations of Childhood Ependymoma:A Multitude of Syndromes
Pediatric Neurosurgery
Jeffrey C. Allen and Joao Siffert and Juliette Hukin
DOI: 10.1159/000028619
1998

Acute Swelling of the Cerebellum in Childhood
Journal of Child Neurology
Juliette Hukin and Douglas D. Cochrane and John U. Crichton
DOI: 10.1177/088307389701200411
06/1997

Basal ganglia infarction associated with HHV-6 infection.
Archives of Disease in Childhood
Webb DW and Bjornson BH and Sargent MA and Hukin J and Thomas EE
DOI: 10.1136/adc.76.4.362
PubMed: 9166034
04/1997

Reye syndrome associated with subclinical varicella zoster virus and influenza a infection
Pediatric Neurology
Juliette Hukin and Anne K. Junker and Eva E. Thomas and Kevin Farrell
DOI: 10.1016/0887-8994(93)90050-m
03/1993

Research

Headstart III
Earlier generations of multi-center "Baby" protocols have demonstrated the feasibility of chemotherapy-only strategies for young children with newly diagnosed malignant brain tumors. The disease-free survivals attained with these regimens, however, were disappointing. The "Head Start I and II" studies demonstrated generally superior outcome for patients with medulloblastoma, other PNET and ependymoma than other such studies.

The primary aim of Headstart III is to determine the two year event-free survival and overall survival from time of study enrollment, for young children with medulloblastoma and other malignant tumours with induction chemotherapy followed by consolidation with myeloablative chemotherapy and autologous hematopoietic cell rescue, with the aim of avoiding, deferring or reducing radiation therapy to the developing brain. Early results are demonstrating favourable outcomes for certain patient groups. We are working on the next study which will be Head Start IV.

Longitudinal study evaluating the recurrence rate in childhood ependymoma
The purpose of this study is to report on the incidence of early and late recurrences in childhood ependymoma, their management and the success thereof, and to evaluate long-term functional status.