Overview

Red blood cell (RBC) transfusion is a mainstay of treatment for individuals requiring surgery, with traumatic injury, undergoing chemotherapy and with anemia due to bone marrow failure or other medical conditions. Despite this, red cell transfusion has been associated with poorer outcome in many of these patient populations [Hebert, 1999, Villaneuva 2013]. As well, it is a costly treatment and the product is often in short supply due to demands in excess of donor availability. Utilization trends increase year over year on a provincial and national basis, and this is unlikely to change in light of our aging population.

For these reasons, there is interest at all levels of care to ensure that RBC transfusion is undertaken only when necessary; when no other reasonable treatment option is available. My current research focuses on assessing blood transfusion practices and adherence to current recommendations.

Publications

Microparticle content of platelet concentrates is predicted by donor microparticles and is altered by production methods and stress.
Maurer-Spurej E, Larsen R, Labrie A, Heaton A, Chipperfield K
DOI: 10.1016/j.transci.2016.07.010
PubMed: 27470708
08/2016

Acquired peanut hypersensitivity following platelet transfusion.
Ponnampalam A, Growe G, Loftus P, Chipperfield K, Bigham M
DOI: 10.1111/tme.12148
PubMed: 25180861
12/2014

Should intraoperative cell-salvaged blood be used in patients with suspected or known malignancy?
Trudeau JD, Waters T, Chipperfield K
DOI: 10.1007/s12630-012-9781-x
PubMed: 22996966
11/2012

Temporal trends in the treatment of severe traumatic hemorrhage.
Heidary B, Bell N, Ngai JT, Simons RK, Chipperfield K, Hameed SM
DOI: 10.1016/j.amjsurg.2011.12.012
PubMed: 22417848
05/2012

Erroneous automated optical platelet counts in 1-hour post-transfusion blood samples.
Maurer-Spurej E, Pittendreigh C, Yakimec J, De Badyn MH, Chipperfield K
DOI: 10.1111/j.1751-553x.2008.01097.x
PubMed: 18752538
02/2010

Concomitant and successive amplifications of MYC in APL-like leukemia.
Bruyère H, Sutherland H, Chipperfield K, Hudoba M
DOI: 10.1016/j.cancergencyto.2009.11.001
PubMed: 20113841
02/2010

Platelet quality measured with dynamic light scattering correlates with transfusion outcome in hematologic malignancies.
Maurer-Spurej E, Labrie A, Pittendreigh C, Chipperfield K, Smith C, Heddle N, Liu Y, Yi QL, Barnett M
DOI: 10.1111/j.1537-2995.2009.02302.x
PubMed: 19903289
11/2009

Past and future approaches to assess the quality of platelets for transfusion.
Maurer-Spurej E, Chipperfield K
DOI: 10.1016/j.tmrv.2007.05.005
PubMed: 17900491
10/2007

Posttransplant diffuse large B-cell lymphoma of "lymphomatoid granulomatosis" type.
Saxena A, Dyker KM, Angel S, Moshynska O, Dharampaul S, Cockroft DW
DOI: 10.1007/s00428-002-0694-x
PubMed: 12587601
12/2002

A novel immunocytochemical assay for the detection of serotonin in platelets.
Maurer-Spurej E, Dyker K, Gahl WA, Devine DV
DOI: 10.1046/j.0007-1048.2001.03302.x
PubMed: 11849219
03/2002

Research

Current Project
I am currently supervising a project to audit RBC transfusions administered across various hospitals in Greater Vancouver. We will gauge whether the transfusion was appropriate or inappropriate based on most current guidelines. The cumulative results of the audit will provide information to hospital Transfusion Medicine (TM) leaders, ordering clinicians, hospital executive and the Ministry of Health (MoH), and form a baseline for future RBC Utilization Management (UM) endeavors. This information will have the potential to influence quality outcomes for patients.

Grants

2010-2011. Canadian Blood Services Grant. (Co-PI with E. Maurer) Comparison of in vivo outcome following transfusion of dynamic light scattering screened versus unscreened platelets.

2011. VCH Quality and Patient Safety. Development of On-line tutorial - Appropriate TM Practice for MD’s.

2010-2014. Co DIVO RCT: A randomized controlled trial of high quality platelet concentrates as determined by ThromboLUX score versus standard of care platelets in patients with hematological malignancy.

Honours & Awards

Award for Excellence in Clinical Service, UBC Dept of Pathology and Laboratory Medicine, 2011.

Faculty of Medicine Clinical Excellence in Teaching Award, UBC. May 2007.