Overview

My clinical research focus areas include prediction of outcomes for children with juvenile idiopathic arthritis and improving care through longitudinal outcomes registries, study of physical activity in children with juvenile idiopathic arthritis, transition of youth with rheumatic disease to adult care, and translational research in autoinflammatory disease. The strong partnerships of our Division of Pediatric Rheumatology as well as pan-Canadian collaborators in the Canadian Alliance for Pediatric Rheumatology Investigators fuel my research projects and ensure successful translation of research results to practice. I have particular interest in creative knowledge translation in pediatric rheumatology research, and active inclusion of patients and families into research.

Publications

Sjögren Syndrome
Textbook of Pediatric Rheumatology
Lori Tucker
DOI: 10.1016/b978-0-323-24145-8.00030-2
2016

Development of a novel renal activity index of lupus nephritis in children & young adultsNoninvasive measurement of lupus nephritis activity
Arthritis Care & Research
Hermine I Brunner, Michael Bennett, Khalid Abulaban, Marisa Klein-Gitelman, Kathleen O'Neil, Lori Tucker, Stacy Ardoin, Kelly Rouster-Stevens, Karen Onel, Nora Singer, B. Anne Eberhard, Larry Jung, Lisa Imundo, Tracey Wright, David Witte, Brad Rovin, Jun Ying, Prasad Devarajan
DOI: 10.1002/acr.22762
10/2015

Cognitive Performance Scores for the Pediatric Automated Neuropsychological Assessment Metrics in Childhood-Onset Systemic Lupus ErythematosusScreening Tool of Cognition in Childhood-Onset SLE
Arthritis Care & Research
Patricia Vega-Fernandez, Shana Vanderburgh White, Frank Zelko, Natasha M. Ruth, Deborah M. Levy, Eyal Muscal, Marisa S. Klein-Gitelman, Adam M. Huber, Lori B. Tucker, Tresa Roebuck-Spencer, Jun Ying, Hermine I. Brunner
DOI: 10.1002/acr.22571
07/2015

The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort
Ann Rheum Dis
Jaime Guzman, Kiem Oen, Adam M Huber, Karen Watanabe Duffy, Gilles Boire, Natalie Shiff, Roberta A Berard, Deborah M Levy, Elizabeth Stringer, Rosie Scuccimarri, Kimberly Morishita, Nicole Johnson, David A Cabral, Alan M Rosenberg, Maggie Larché, Paul Dancey, Ross E Petty, Ronald M Laxer, Earl Silverman, Paivi Miettunen, Anne-Laure Chetaille, Elie Haddad, Kristin Houghton, Lynn Spiegel, Stuart E Turvey, Heinrike Schmeling, Bianca Lang, Janet Ellsworth, Suzanne E Ramsey, Alessandra Bruns, Johannes Roth, Sarah Campillo, Susanne Benseler, Gaëlle Chédeville, Rayfel Schneider, Shirley M L Tse, Roxana Bolaria, Katherine Gross, Brian Feldman, Debbie Feldman, Bonnie Cameron, Roman Jurencak, Jean Dorval, Claire LeBlanc, Claire St. Cyr, Michele Gibbon, Rae S M Yeung, Ciarán M Duffy, Lori B Tucker
DOI: 10.1136/annrheumdis-2014-207164
05/2015

Association of Health-Related Quality of Life in Childhood-Onset Systemic Lupus Erythematosus With Ethnicity: Results From a Multiethnic Multicenter Canadian CohortInfluence of Ethnicity on HRQOL in Canadian cSLE Patients
Arthritis Care & Research
Deborah M. Levy, Christine A. Peschken, Lori B. Tucker, Gaëlle Chédeville, Adam M. Huber, Janet E. Pope, Earl D. Silverman, Canadian Network for Improved Outcomes in SLE (CaNIOS) 1000 Faces Investigators
DOI: 10.1002/acr.22363
11/2014

The prevalence of systemic autoimmune rheumatic diseases in Canadian pediatric populations: administrative database estimates
Rheumatol Int
Natalie Jane Shiff, Lisa M. Lix, Lawrence Joseph, Ciaran Duffy, Lori B. Tucker, Lawrence W. Svenson, Patrick Belisle, Sasha Bernatsky
DOI: 10.1007/s00296-014-3136-6
09/2014

Chronic inflammatory arthritis prevalence estimates for children and adolescents in three Canadian provinces
Rheumatol Int
Natalie Jane Shiff, Lisa M. Lix, Kiem Oen, Lawrence Joseph, Ciaran Duffy, Elizabeth Stringer, Lori B. Tucker, Lawrence W. Svenson, Patrick Belisle, Sasha Bernatsky
DOI: 10.1007/s00296-014-3085-0
07/2014

The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort
Ann Rheum Dis
Jaime Guzman, Kiem Oen, Lori B Tucker, Adam M Huber, Natalie Shiff, Gilles Boire, Rosie Scuccimarri, Roberta Berard, Shirley M L Tse, Kimberly Morishita, Elizabeth Stringer, Nicole Johnson, Deborah M Levy, Karen Watanabe Duffy, David A Cabral, Alan M Rosenberg, Maggie Larché, Paul Dancey, Ross E Petty, Ronald M Laxer, Earl Silverman, Paivi Miettunen, Anne-Laure Chetaille, Elie Haddad, Kristin Houghton, Lynn Spiegel, Stuart E Turvey, Heinrike Schmeling, Bianca Lang, Janet Ellsworth, Suzanne Ramsey, Alessandra Bruns, Sarah Campillo, Susanne Benseler, Gaëlle Chédeville, Rayfel Schneider, Rae Yeung, Ciarán M Duffy
DOI: 10.1136/annrheumdis-2014-205372
05/2014

A67: Factors That Contribute to Classification of Children as Having Undifferentiated Juvenile Idiopathic Arthritis
Arthritis & Rheumatology
Mercedes O. Chan, Ross E. Petty, Kiem Oen, Ciarán M. Duffy, Lori B. Tucker, Rae SM Yeung, Jaime Guzman, The ReACCh Out Investigators
DOI: 10.1002/art.38483
03/2014

A96: The Roller Coaster of Juvenile Idiopathic Arthritis: A Qualitative Examination of Parents' Emotional Responses to the Disease and Its Management
Arthritis & Rheumatology
Oralia Gomez-Ramirez, Michele Gibbon, Roberta A. Berard, Roman Jurencak, Jayne Green, Susanne Benseler, Ciarán M. Duffy, Lori B. Tucker, Ross E. Petty, Natalie Shiff, Kiem Oen, Rollin Brant, Jaime Guzman
DOI: 10.1002/art.38513
03/2014

A108: Linking Exercise, Activity and Pathophysiology in Childhood Arthritis: An Innovative Canadian Knowledge Translation Strategy
Arthritis & Rheumatology
Michele Gibbon, Lori B. Tucker, Debbie Ehrmann Feldman, Heather A. McKay, Joanie Sims-Gould, Jennifer N. Stinson, Elizabeth Stringer, Shirley M. L. Tse, Ciarán M. Duffy, LEAP Study Investigators
DOI: 10.1002/art.38529
03/2014

A33: Cognitive Performance Scores for the Pediatric Automated Neuropsychological Assessment Metrics in Childhood-Onset Systemic Lupus Erythematosus
Arthritis & Rheumatology
Patricia Vega-Fernandez, Shana Vanderburgh, Natasha M. Ruth, Deborah M. Levy, Frank A. Zelko, Eyal Muscal, Marisa S. Klein-Gitelman, Adam Huber, Kasha Wiley, Erin C. Thomas, Lori B. Tucker, Tresa Roebuck-Spencer, Jun Ying, Hermine Brunner
DOI: 10.1002/art.38449
03/2014

A13: The Research in Arthritis in Canadian Children Emphasizing Outcomes (ReACCh Out) Cohort: Prospective Determination of the Incidence of New Onset Uveitis in Juvenile Idiopathic Arthritis
Arthritis & Rheumatology
Karen N Watanabe Duffy, Jennifer Lee, Jaime Guzman, Nick Barrowman, Kimberly Morishita, Lynn R. Spiegel, Elizabeth Stringer, Michele Gibbon, Rae SM Yeung, Lori B. Tucker, Kiem Oen, Ciarán M. Duffy, ReACChOut Investigators
DOI: 10.1002/art.38424
03/2014

A21: Physical Activity in Children with Juvenile Idiopathic Arthritis (JIA): The LEAP (Linking Exercise, Activity, and Pathophysiology in Childhood Arthritis) Study
Arthritis & Rheumatology
Lori B. Tucker, Heather A. McKay, Leanne M. Ward, Kristin M. Houghton, Alan M. Rosenberg, Debbie Ehrmann Feldman, Kiem Oen, Johannes Roth, Elizabeth Stringer, Adam Baxter-Jones, Ciarán M. Duffy, LEAP Study LEAP Study Investigators
DOI: 10.1002/art.38437
03/2014

A systematic review of transition readiness and transfer satisfaction measures for adolescents with chronic illness
International Journal of Adolescent Medicine and Health
Jennifer Stinson, Sara Ahola Kohut, Lynn Spiegel, Meghan White, Navreet Gill, Gina Colbourne, Samantha Sigurdson, Karen Watanabe Duffy, Lori Tucker, Elizabeth Stringer, Beth Hazel, Jacqueline Hochman, John Reiss, Miriam Kaufman
DOI: 10.1515/ijamh-2013-0512
01/2014

The risk and nature of flares in juvenile idiopathic arthritis: results from the reACCh-Out cohort
Pediatric Rheumatology
Jaime Guzman, Kiem Oen, Adam M Huber, Gilles Boire, Karen Duffy, Roberta Berard, Natalie J Shiff, Deborah M Levy, Elizabeth Stringer, Kimberly Morishita, Rosie Scuccimarri, Lori B Tucker, Rae SM Yeung, Ciaran Duffy, ReACCh-Out Investigators
DOI: 10.1186/1546-0096-12-s1-o9
2014

The child patient
Oxford Textbook of Rheumatology
Lori B. Tucker
DOI: 10.1093/med/9780199642489.003.0001
10/2013

Association of Smoking With Cutaneous Manifestations in Systemic Lupus ErythematosusSmoking and Cutaneous Involvement in SLE
Arthritis Care & Research
Josiane Bourré-Tessier, Christine A. Peschken, Sasha Bernatsky, Lawrence Joseph, Ann E. Clarke, Paul R. Fortin, Carol Hitchon, Shikha Mittoo, C. Douglas Smith, Michel Zummer, Janet Pope, Lori Tucker, Marie Hudson, Hector Arbillaga, John Esdaile, Earl Silverman, Gaelle Chédeville, Adam M. Huber, Patrick Belisle, Christian A. Pineau, The Canadian Network for Improved Outcomes in Systemic Lupus Erythematosus 1000 Canadian Faces of Lupus Investigators
DOI: 10.1002/acr.21966
07/2013

Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus
Ann Rheum Dis
Rina Mina, Marisa S Klein-Gitelman, Shannen Nelson, B Anne Eberhard, Gloria Higgins, Nora G Singer, Karen Onel, Lori Tucker, Kathleen M O'Neil, Marilynn Punaro, Deborah M Levy, Kathleen Haines, Alberto Martini, Nicolino Ruperto, Daniel Lovell, Hermine I Brunner
DOI: 10.1136/annrheumdis-2012-202376
01/2013

Neuropsychiatric Lupus: The Prevalence and Autoantibody Associations Depend on the Definition: Results from the 1000 Faces of Lupus Cohort
Seminars in Arthritis and Rheumatism
Alan M. Borowoy, Janet E. Pope, Earl Silverman, Paul R. Fortin, Christian Pineau, C. Douglas Smith, Hector Arbillaga, Dafna Gladman, Murray Urowitz, Michel Zummer, Marie Hudson, Lori Tucker, Christine Peschken
DOI: 10.1016/j.semarthrit.2012.03.011
10/2012

158. Development and Testing of the Readiness for Adult Care in Rheumatology (RACER) Questionnaire for Adolescents With Rheumatic Conditions
Journal of Adolescent Health
Jennifer Stinson, Lynn Spiegel, Karen Watanabe Duffy, Lori Tucker, Elizabeth Stringer, Elizabeth Hazel, Jacqueline Hochman, Navreet Gill, Gina Colbourne, Samantha Sigurdson, Miriam Kaufman
DOI: 10.1016/j.jadohealth.2011.10.234
02/2012

Influence of ethnicity on childhood-onset systemic lupus erythematosus: Results from a multiethnic multicenter Canadian cohort
Arthritis Care Res
Deborah M. Levy, Christine A. Peschken, Lori B. Tucker, Gaëlle Chédeville, Adam M. Huber, Janet E. Pope, Earl D. Silverman, the Canadian Network for Improved Outcomes in SLE 1000 Faces Investigators
DOI: 10.1002/acr.21779
2012

The 1000 Canadian faces of systemic lupus erythematosus: effect of ethnicity on baseline pediatric data
Pediatric Rheumatology
Deborah M Levy, Earl D Silverman, Lori B Tucker, Gaelle Chédeville, Adam Huber, Janet E Pope, Christine A Peschken, CaNIOS Investigators
DOI: 10.1186/1546-0096-10-s1-a18
2012

Improving transition readiness and quality of life (QOL) with a pediatric lupus health passport
Pediatric Rheumatology
Emily Von Scheven, Lori B Tucker, Lakshmi N Moorthy, Erica F Lawson, Carolyn Neville, Deborah DaCosta, Paul R Fortin
DOI: 10.1186/1546-0096-10-s1-a23
2012

Preliminary criteria for global flares in childhood-onset systemic lupus erythematosus
Arthritis Care Res
Hermine I. Brunner, Rina Mina, Clarissa Pilkington, Michael W. Beresford, Andreas Reiff, Deborah M. Levy, Lori B. Tucker, B. Anne Eberhard, Angelo Ravelli, Laura E. Schanberg, Claudia Saad-Magalhaes, Gloria C. Higgins, Karen Onel, Nora G. Singer, Emily von Scheven, Lukasz Itert, Marisa S. Klein-Gitelman, Marilynn Punaro, Jun Ying, Edward H. Giannini
DOI: 10.1002/acr.20507
08/2011

Defining clinical remission and clinically inactive disease in juvenile systemic lupus erythematosus (jSLE)
Pediatric Rheumatology
Rina Mina, Laura Schanberg, Anne B Eberhard, Marisa Klein–Gitelman, Gloria Higgins, Karen Onel, Nora G Singer, Kathleen O’ Neil, Lori Tucker, Deborah Levy, Wajeeha Yousaf, Shannen Nelson, Michael Beresford, Ruben Cuttica, Graciela Espada, Angelo Ravelli, Alberto Martini, Edward Giannini, Hermine I Brunner
DOI: 10.1186/1546-0096-9-s1-o17
2011

SJÖGREN’S SYNDROME
Textbook of Pediatric Rheumatology
Lori B. Tucker
DOI: 10.1016/b978-1-4160-6581-4.10028-7
2011

Infrapatellar bursitis in children with juvenile idiopathic arthritis: a case series
Clin Rheumatol
Jubran T. Alqanatish, Ross E. Petty, Kristin M. Houghton, Jaime Guzman, Lori B. Tucker, David A. Cabral, Robyn A. Cairns
DOI: 10.1007/s10067-010-1620-2
11/2010

Usability Testing of an Online Self-management Program for Adolescents With Juvenile Idiopathic Arthritis
J Med Internet Res
Jennifer Stinson, Patrick McGrath, Ellen Hodnett, Brian Feldman, Ciaran Duffy, Adam Huber, Lori Tucker, Ross Hetherington, Shirley Tse, Lynn Spiegel, Sarah Campillo, Navreet Gill, Meghan White
DOI: 10.2196/jmir.1349
07/2010

Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort
Arthritis Care Res
Kiem Oen, Ciarán M. Duffy, Shirley M. L. Tse, Suzanne Ramsey, Janet Ellsworth, Gaëlle Chédeville, Anne-Laure Chetaille, Claire Saint-Cyr, David A. Cabral, Lynn R. Spiegel, Rayfel Schneider, Bianca Lang, Adam M. Huber, Paul Dancey, Earl Silverman, Alan M. Rosenberg, Bonnie Cameron, Nicole Johnson, Jean Dorval, Rosie Scuccimarri, Sarah Campillo, Ross E. Petty, Karen N. Watanabe Duffy, Gilles Boire, Elie Haddad, Kristin Houghton, Ronald Laxer, Stuart E. Turvey, Paivi Miettunen, Katherine Gross, Jaime Guzman, Susanne Benseler, Brian M. Feldman, Victor Espinosa, Rae S. M. Yeung, Lori Tucker
DOI: 10.1002/acr.20044
04/2010

The Young Person with Systemic Lupus Erythematosus
Adolescent Rheumatology
Lori Tucker
DOI: 10.3109/9781420021103-9
03/2008

Fitness, fatigue, disease activity, and quality of life in pediatric lupus
Arthritis Rheum
Kristin M. Houghton, Lori B. Tucker, James E. Potts, Donald C. Mckenzie
DOI: 10.1002/art.23534
2008

Transition of the Adolescent Patient with Rheumatic Disease: Issues to Consider
Pediatric Clinics of North America
Lori B. Tucker, David A. Cabral
DOI: 10.1016/j.pcl.2005.01.008
04/2005

Controversies and advances in the management of systemic lupus erythematosus in children and adolescents
Best Practice & Research Clinical Rheumatology
Lori B Tucker
DOI: 10.1053/berh.2002.0254
07/2002

Outcome measures in childhood rheumatic diseases
Curr Rheumatol Rep
Lori B. Tucker
DOI: 10.1007/s11926-000-0074-y
08/2000

Malignancies in children who initially present with rheumatic complaints
The Journal of Pediatrics
David A. Cabral, Lori B. Tucker
DOI: 10.1016/s0022-3476(99)70372-0
01/1999

SOLUBLE ADHESION MOLECULES IN JUVENILE RHEUMA TOID ARTHRITIS • 1838
Pediatr Res
Bradley J Bloom, Lori B Tucker, Laurie C Miller, Jane G Schaller, Peter R Blier
DOI: 10.1203/00006450-199704001-01857
04/1997

Prolonged fevers of unknown origin in children: Patterns of presentation and outcome
The Journal of Pediatrics
Laurie C. Miller, Betsy A. Sisson, Lori B. Tucker, Jane G. Schaller
DOI: 10.1016/s0022-3476(96)70075-6
09/1996

Nonrheumatic conditions in children including infectious diseases and syndromes
Current Opinion in Rheumatology
Lori B. Tucker
DOI: 10.1097/00002281-199509000-00010
09/1995

Vasculitis, Kawasaki disease, and hemolytic uremic syndrome
Current Opinion in Rheumatology
Lori B. Tucker
DOI: 10.1097/00002281-199409000-00013
09/1994

Juvenile rheumatoid arthritis
Current Opinion in Rheumatology
Lori B. Tucker
DOI: 10.1097/00002281-199305050-00010
09/1993

Human parvovirus B19-associatedarthritis in children
The Journal of Pediatrics
James J. Nocton, Laurie C. Miller, Lori B. Tucker, Jane G. Schaller
DOI: 10.1016/s0022-3476(06)80111-3
02/1993

Systemic lupus erythematosus, dermatomyositis, scleroderma, vasculopathies, and other connective tissue disorders in children
Current Opinion in Rheumatology
Lori B. Tucker
DOI: 10.1097/00002281-199110000-00016
10/1991

Postnatal progression from second- to third-degree heart block in neonatal lupus syndrome
The Journal of Pediatrics
Robert L. Geggel, Lori Tucker, Jlona Szer
DOI: 10.1016/s0022-3476(88)80581-x
1988

Antiphospholipid Syndrome in Children
Hughes Syndrome
Lori B. Tucker, Rolando Cimaz
DOI: 10.1007/1-84628-009-5_20

Research

Promoting successful transition from pediatric rheumatology care to adult care for youth with chronic rheumatic diseases:
I am a collaborator on several projects aimed at development and testing of transition resources for youth and younger children with JIA or other rheumatic diseases. Our research group is currently doing a randomized controlled trial of a youth on line self management website called Teens Taking Charge, aimed at youth with JIA. We are in the development phase for a similar self management program for younger children with JIA and their parents. We are also starting final testing of a transition questionnaire called RACER (Readiness for Adult Care in Rheumatology), which will be tested in a number of Canadian pediatric rheumatology centres.

LEAP: Linking Exercise, Activity and Pathophysiology in Canadian Children with Arthritis: A Pan-Canadian Team:
I am a co-nominated Principal Investigator on this pan-Canadian project studying physical activity in children with JIA. Our project aims are to study the determinants of physical activity in children with JIA, to examine variables that predict PA in these patients, and to determine how PA influences clinical outcomes, inflammatory biomarkers, and the development of bone and muscle in children with JIA. The project involves 12 pediatric rheumatology centres across Canada and we have enrolled nearly 500 children and youth with JIA into a 2 year longitudinal study, looking at their level of PA over time as well as clinical, inflammatory, bone and muscle parameters. In addition, we are performing a novel pilot exercise intervention study, looking at new ways to encourage increased targeted activity in children with JIA that is safe and effective as well as fun.

ReACCH-Out: Research on Arthritis in Canadian Children, Emphasizing Outcomes: a Canadian multi-centre collaborative outcomes study
I am one of four principal investigators for this seminal CIHR-funded NET project, in which our pediatric rheumatology research program in Canada enrolled 1,500 newly diagnosed children with JIA into a longitudinal registry. This project has resulted in 6 publications to date and a number more in preparation, and is providing us with important data demonstrating the trajectory of JIA using modern treatments, prediction of disease course using disease features from early in disease, evaluation of pain over the course of JIA, incidence and prevalence of JIA-associated uveitis, as well as other areas of research. This project has provided the infrastructure to allow CAPRI to obtain funding and move forward to establish a long-lasting Canadian JIA registry.

Research Group Members

Felice Mizan, Research Coordinator
Angelyne Sarmiento, Research Manager