Overview

My clinical research focus areas include prediction of outcomes for children with juvenile idiopathic arthritis and improving care through longitudinal outcomes registries, study of physical activity in children with juvenile idiopathic arthritis, transition of youth with rheumatic disease to adult care, and translational research in autoinflammatory disease. The strong partnerships of our Division of Pediatric Rheumatology as well as pan-Canadian collaborators in the Canadian Alliance for Pediatric Rheumatology Investigators fuel my research projects and ensure successful translation of research results to practice. I have particular interest in creative knowledge translation in pediatric rheumatology research, and active inclusion of patients and families into research.

Publications

Sjögren Syndrome
Textbook of Pediatric Rheumatology
Lori Tucker
DOI: 10.1016/b978-0-323-24145-8.00030-2
2016

Development of a novel renal activity index of lupus nephritis in children & young adults
Arthritis Care & Research
Hermine I Brunner and Michael Bennett and Khalid Abulaban and Marisa Klein-Gitelman and Kathleen O'Neil and Lori Tucker and Stacy Ardoin and Kelly Rouster-Stevens and Karen Onel and Nora Singer and B. Anne Eberhard and Larry Jung and Lisa Imundo and Tracey Wright and David Witte and Brad Rovin and Jun Ying and Prasad Devarajan
DOI: 10.1002/acr.22762
10/2015

Cognitive Performance Scores for the Pediatric Automated Neuropsychological Assessment Metrics in Childhood-Onset Systemic Lupus Erythematosus
Arthritis Care & Research
Patricia Vega-Fernandez and Shana Vanderburgh White and Frank Zelko and Natasha M. Ruth and Deborah M. Levy and Eyal Muscal and Marisa S. Klein-Gitelman and Adam M. Huber and Lori B. Tucker and Tresa Roebuck-Spencer and Jun Ying and Hermine I. Brunner
DOI: 10.1002/acr.22571
07/2015

The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort
Ann Rheum Dis
Jaime Guzman and Kiem Oen and Adam M Huber and Karen Watanabe Duffy and Gilles Boire and Natalie Shiff and Roberta A Berard and Deborah M Levy and Elizabeth Stringer and Rosie Scuccimarri and Kimberly Morishita and Nicole Johnson and David A Cabral and Alan M Rosenberg and Maggie Larché and Paul Dancey and Ross E Petty and Ronald M Laxer and Earl Silverman and Paivi Miettunen and Anne-Laure Chetaille and Elie Haddad and Kristin Houghton and Lynn Spiegel and Stuart E Turvey and Heinrike Schmeling and Bianca Lang and Janet Ellsworth and Suzanne E Ramsey and Alessandra Bruns and Johannes Roth and Sarah Campillo and Susanne Benseler and Gaëlle Chédeville and Rayfel Schneider and Shirley M L Tse and Roxana Bolaria and Katherine Gross and Brian Feldman and Debbie Feldman and Bonnie Cameron and Roman Jurencak and Jean Dorval and Claire LeBlanc and Claire St. Cyr and Michele Gibbon and Rae S M Yeung and Ciarán M Duffy and Lori B Tucker
DOI: 10.1136/annrheumdis-2014-207164
05/2015

Association of Health-Related Quality of Life in Childhood-Onset Systemic Lupus Erythematosus With Ethnicity: Results From a Multiethnic Multicenter Canadian Cohort
Arthritis Care & Research
Deborah M. Levy and Christine A. Peschken and Lori B. Tucker and Gaëlle Chédeville and Adam M. Huber and Janet E. Pope and Earl D. Silverman and Canadian Network for Improved Outcomes in SLE (CaNIOS) 1000 Faces Investigators
DOI: 10.1002/acr.22363
11/2014

The prevalence of systemic autoimmune rheumatic diseases in Canadian pediatric populations: administrative database estimates
Rheumatol Int
Natalie Jane Shiff and Lisa M. Lix and Lawrence Joseph and Ciaran Duffy and Lori B. Tucker and Lawrence W. Svenson and Patrick Belisle and Sasha Bernatsky
DOI: 10.1007/s00296-014-3136-6
09/2014

Chronic inflammatory arthritis prevalence estimates for children and adolescents in three Canadian provinces
Rheumatol Int
Natalie Jane Shiff and Lisa M. Lix and Kiem Oen and Lawrence Joseph and Ciaran Duffy and Elizabeth Stringer and Lori B. Tucker and Lawrence W. Svenson and Patrick Belisle and Sasha Bernatsky
DOI: 10.1007/s00296-014-3085-0
07/2014

The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort
Ann Rheum Dis
Jaime Guzman and Kiem Oen and Lori B Tucker and Adam M Huber and Natalie Shiff and Gilles Boire and Rosie Scuccimarri and Roberta Berard and Shirley M L Tse and Kimberly Morishita and Elizabeth Stringer and Nicole Johnson and Deborah M Levy and Karen Watanabe Duffy and David A Cabral and Alan M Rosenberg and Maggie Larché and Paul Dancey and Ross E Petty and Ronald M Laxer and Earl Silverman and Paivi Miettunen and Anne-Laure Chetaille and Elie Haddad and Kristin Houghton and Lynn Spiegel and Stuart E Turvey and Heinrike Schmeling and Bianca Lang and Janet Ellsworth and Suzanne Ramsey and Alessandra Bruns and Sarah Campillo and Susanne Benseler and Gaëlle Chédeville and Rayfel Schneider and Rae Yeung and Ciarán M Duffy
DOI: 10.1136/annrheumdis-2014-205372
05/2014

A33: Cognitive Performance Scores for the Pediatric Automated Neuropsychological Assessment Metrics in Childhood-Onset Systemic Lupus Erythematosus
Arthritis & Rheumatology
Patricia Vega-Fernandez and Shana Vanderburgh and Natasha M. Ruth and Deborah M. Levy and Frank A. Zelko and Eyal Muscal and Marisa S. Klein-Gitelman and Adam Huber and Kasha Wiley and Erin C. Thomas and Lori B. Tucker and Tresa Roebuck-Spencer and Jun Ying and Hermine Brunner
DOI: 10.1002/art.38449
03/2014

A21: Physical Activity in Children with Juvenile Idiopathic Arthritis (JIA): The LEAP (Linking Exercise, Activity, and Pathophysiology in Childhood Arthritis) Study
Arthritis & Rheumatology
Lori B. Tucker and Heather A. McKay and Leanne M. Ward and Kristin M. Houghton and Alan M. Rosenberg and Debbie Ehrmann Feldman and Kiem Oen and Johannes Roth and Elizabeth Stringer and Adam Baxter-Jones and Ciarán M. Duffy and LEAP Study LEAP Study Investigators
DOI: 10.1002/art.38437
03/2014

A13: The Research in Arthritis in Canadian Children Emphasizing Outcomes (ReACCh Out) Cohort: Prospective Determination of the Incidence of New Onset Uveitis in Juvenile Idiopathic Arthritis
Arthritis & Rheumatology
Karen N Watanabe Duffy and Jennifer Lee and Jaime Guzman and Nick Barrowman and Kimberly Morishita and Lynn R. Spiegel and Elizabeth Stringer and Michele Gibbon and Rae SM Yeung and Lori B. Tucker and Kiem Oen and Ciarán M. Duffy and ReACChOut Investigators
DOI: 10.1002/art.38424
03/2014

A67: Factors That Contribute to Classification of Children as Having Undifferentiated Juvenile Idiopathic Arthritis
Arthritis & Rheumatology
Mercedes O. Chan and Ross E. Petty and Kiem Oen and Ciarán M. Duffy and Lori B. Tucker and Rae SM Yeung and Jaime Guzman and The ReACCh Out Investigators
DOI: 10.1002/art.38483
03/2014

A96: The Roller Coaster of Juvenile Idiopathic Arthritis: A Qualitative Examination of Parents' Emotional Responses to the Disease and Its Management
Arthritis & Rheumatology
Oralia Gomez-Ramirez and Michele Gibbon and Roberta A. Berard and Roman Jurencak and Jayne Green and Susanne Benseler and Ciarán M. Duffy and Lori B. Tucker and Ross E. Petty and Natalie Shiff and Kiem Oen and Rollin Brant and Jaime Guzman
DOI: 10.1002/art.38513
03/2014

A108: Linking Exercise, Activity and Pathophysiology in Childhood Arthritis: An Innovative Canadian Knowledge Translation Strategy
Arthritis & Rheumatology
Michele Gibbon and Lori B. Tucker and Debbie Ehrmann Feldman and Heather A. McKay and Joanie Sims-Gould and Jennifer N. Stinson and Elizabeth Stringer and Shirley M. L. Tse and Ciarán M. Duffy and LEAP Study Investigators
DOI: 10.1002/art.38529
03/2014

A systematic review of transition readiness and transfer satisfaction measures for adolescents with chronic illness
International Journal of Adolescent Medicine and Health
Jennifer Stinson and Sara Ahola Kohut and Lynn Spiegel and Meghan White and Navreet Gill and Gina Colbourne and Samantha Sigurdson and Karen Watanabe Duffy and Lori Tucker and Elizabeth Stringer and Beth Hazel and Jacqueline Hochman and John Reiss and Miriam Kaufman
DOI: 10.1515/ijamh-2013-0512
01/2014

The risk and nature of flares in juvenile idiopathic arthritis: results from the reACCh-Out cohort
Pediatric Rheumatology
Jaime Guzman and Kiem Oen and Adam M Huber and Gilles Boire and Karen Duffy and Roberta Berard and Natalie J Shiff and Deborah M Levy and Elizabeth Stringer and Kimberly Morishita and Rosie Scuccimarri and Lori B Tucker and Rae SM Yeung and Ciaran Duffy and ReACCh-Out Investigators
DOI: 10.1186/1546-0096-12-s1-o9
2014

The child patient
Oxford Textbook of Rheumatology
Lori B. Tucker
DOI: 10.1093/med/9780199642489.003.0001
10/2013

Association of Smoking With Cutaneous Manifestations in Systemic Lupus Erythematosus
Arthritis Care & Research
Josiane Bourré-Tessier and Christine A. Peschken and Sasha Bernatsky and Lawrence Joseph and Ann E. Clarke and Paul R. Fortin and Carol Hitchon and Shikha Mittoo and C. Douglas Smith and Michel Zummer and Janet Pope and Lori Tucker and Marie Hudson and Hector Arbillaga and John Esdaile and Earl Silverman and Gaelle Chédeville and Adam M. Huber and Patrick Belisle and Christian A. Pineau and The Canadian Network for Improved Outcomes in Systemic Lupus Erythematosus 1000 Canadian Faces of Lupus Investigators
DOI: 10.1002/acr.21966
07/2013

Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus
Ann Rheum Dis
Rina Mina and Marisa S Klein-Gitelman and Shannen Nelson and B Anne Eberhard and Gloria Higgins and Nora G Singer and Karen Onel and Lori Tucker and Kathleen M O'Neil and Marilynn Punaro and Deborah M Levy and Kathleen Haines and Alberto Martini and Nicolino Ruperto and Daniel Lovell and Hermine I Brunner
DOI: 10.1136/annrheumdis-2012-202376
01/2013

Neuropsychiatric Lupus: The Prevalence and Autoantibody Associations Depend on the Definition: Results from the 1000 Faces of Lupus Cohort
Seminars in Arthritis and Rheumatism
Alan M. Borowoy and Janet E. Pope and Earl Silverman and Paul R. Fortin and Christian Pineau and C. Douglas Smith and Hector Arbillaga and Dafna Gladman and Murray Urowitz and Michel Zummer and Marie Hudson and Lori Tucker and Christine Peschken
DOI: 10.1016/j.semarthrit.2012.03.011
10/2012

158. Development and Testing of the Readiness for Adult Care in Rheumatology (RACER) Questionnaire for Adolescents With Rheumatic Conditions
Journal of Adolescent Health
Jennifer Stinson and Lynn Spiegel and Karen Watanabe Duffy and Lori Tucker and Elizabeth Stringer and Elizabeth Hazel and Jacqueline Hochman and Navreet Gill and Gina Colbourne and Samantha Sigurdson and Miriam Kaufman
DOI: 10.1016/j.jadohealth.2011.10.234
02/2012

Influence of ethnicity on childhood-onset systemic lupus erythematosus: Results from a multiethnic multicenter Canadian cohort
Arthritis Care Res
Deborah M. Levy and Christine A. Peschken and Lori B. Tucker and Gaëlle Chédeville and Adam M. Huber and Janet E. Pope and Earl D. Silverman and the Canadian Network for Improved Outcomes in SLE 1000 Faces Investigators
DOI: 10.1002/acr.21779
2012

The 1000 Canadian faces of systemic lupus erythematosus: effect of ethnicity on baseline pediatric data
Pediatric Rheumatology
Deborah M Levy and Earl D Silverman and Lori B Tucker and Gaelle Chédeville and Adam Huber and Janet E Pope and Christine A Peschken and CaNIOS Investigators
DOI: 10.1186/1546-0096-10-s1-a18
2012

Improving transition readiness and quality of life (QOL) with a pediatric lupus health passport
Pediatric Rheumatology
Emily Von Scheven and Lori B Tucker and Lakshmi N Moorthy and Erica F Lawson and Carolyn Neville and Deborah DaCosta and Paul R Fortin
DOI: 10.1186/1546-0096-10-s1-a23
2012

Preliminary criteria for global flares in childhood-onset systemic lupus erythematosus
Arthritis Care Res
Hermine I. Brunner and Rina Mina and Clarissa Pilkington and Michael W. Beresford and Andreas Reiff and Deborah M. Levy and Lori B. Tucker and B. Anne Eberhard and Angelo Ravelli and Laura E. Schanberg and Claudia Saad-Magalhaes and Gloria C. Higgins and Karen Onel and Nora G. Singer and Emily von Scheven and Lukasz Itert and Marisa S. Klein-Gitelman and Marilynn Punaro and Jun Ying and Edward H. Giannini
DOI: 10.1002/acr.20507
08/2011

SJÖGREN’S SYNDROME
Textbook of Pediatric Rheumatology
Lori B. Tucker
DOI: 10.1016/b978-1-4160-6581-4.10028-7
2011

Defining clinical remission and clinically inactive disease in juvenile systemic lupus erythematosus (jSLE)
Pediatric Rheumatology
Rina Mina and Laura Schanberg and Anne B Eberhard and Marisa Klein–Gitelman and Gloria Higgins and Karen Onel and Nora G Singer and Kathleen O’ Neil and Lori Tucker and Deborah Levy and Wajeeha Yousaf and Shannen Nelson and Michael Beresford and Ruben Cuttica and Graciela Espada and Angelo Ravelli and Alberto Martini and Edward Giannini and Hermine I Brunner
DOI: 10.1186/1546-0096-9-s1-o17
2011

Infrapatellar bursitis in children with juvenile idiopathic arthritis: a case series
Clin Rheumatol
Jubran T. Alqanatish and Ross E. Petty and Kristin M. Houghton and Jaime Guzman and Lori B. Tucker and David A. Cabral and Robyn A. Cairns
DOI: 10.1007/s10067-010-1620-2
11/2010

Usability Testing of an Online Self-management Program for Adolescents With Juvenile Idiopathic Arthritis
J Med Internet Res
Jennifer Stinson and Patrick McGrath and Ellen Hodnett and Brian Feldman and Ciaran Duffy and Adam Huber and Lori Tucker and Ross Hetherington and Shirley Tse and Lynn Spiegel and Sarah Campillo and Navreet Gill and Meghan White
DOI: 10.2196/jmir.1349
07/2010

Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort
Arthritis Care Res
Kiem Oen and Ciarán M. Duffy and Shirley M. L. Tse and Suzanne Ramsey and Janet Ellsworth and Gaëlle Chédeville and Anne-Laure Chetaille and Claire Saint-Cyr and David A. Cabral and Lynn R. Spiegel and Rayfel Schneider and Bianca Lang and Adam M. Huber and Paul Dancey and Earl Silverman and Alan M. Rosenberg and Bonnie Cameron and Nicole Johnson and Jean Dorval and Rosie Scuccimarri and Sarah Campillo and Ross E. Petty and Karen N. Watanabe Duffy and Gilles Boire and Elie Haddad and Kristin Houghton and Ronald Laxer and Stuart E. Turvey and Paivi Miettunen and Katherine Gross and Jaime Guzman and Susanne Benseler and Brian M. Feldman and Victor Espinosa and Rae S. M. Yeung and Lori Tucker
DOI: 10.1002/acr.20044
04/2010

The Young Person with Systemic Lupus Erythematosus
Adolescent Rheumatology
Lori Tucker
DOI: 10.3109/9781420021103-9
03/2008

Fitness, fatigue, disease activity, and quality of life in pediatric lupus
Arthritis Rheum
Kristin M. Houghton and Lori B. Tucker and James E. Potts and Donald C. Mckenzie
DOI: 10.1002/art.23534
2008

Transition of the Adolescent Patient with Rheumatic Disease: Issues to Consider
Pediatric Clinics of North America
Lori B. Tucker and David A. Cabral
DOI: 10.1016/j.pcl.2005.01.008
04/2005

Controversies and advances in the management of systemic lupus erythematosus in children and adolescents
Best Practice & Research Clinical Rheumatology
Lori B Tucker
DOI: 10.1053/berh.2002.0254
07/2002

Outcome measures in childhood rheumatic diseases
Curr Rheumatol Rep
Lori B. Tucker
DOI: 10.1007/s11926-000-0074-y
08/2000

Malignancies in children who initially present with rheumatic complaints
The Journal of Pediatrics
David A. Cabral and Lori B. Tucker
DOI: 10.1016/s0022-3476(99)70372-0
01/1999

SOLUBLE ADHESION MOLECULES IN JUVENILE RHEUMA TOID ARTHRITIS • 1838
Pediatr Res
Bradley J Bloom and Lori B Tucker and Laurie C Miller and Jane G Schaller and Peter R Blier
DOI: 10.1203/00006450-199704001-01857
04/1997

Prolonged fevers of unknown origin in children: Patterns of presentation and outcome
The Journal of Pediatrics
Laurie C. Miller and Betsy A. Sisson and Lori B. Tucker and Jane G. Schaller
DOI: 10.1016/s0022-3476(96)70075-6
09/1996

Nonrheumatic conditions in children including infectious diseases and syndromes
Current Opinion in Rheumatology
Lori B. Tucker
DOI: 10.1097/00002281-199509000-00010
09/1995

Vasculitis, Kawasaki disease, and hemolytic uremic syndrome
Current Opinion in Rheumatology
Lori B. Tucker
DOI: 10.1097/00002281-199409000-00013
09/1994

Juvenile rheumatoid arthritis
Current Opinion in Rheumatology
Lori B. Tucker
DOI: 10.1097/00002281-199305050-00010
09/1993

Human parvovirus B19-associatedarthritis in children
The Journal of Pediatrics
James J. Nocton and Laurie C. Miller and Lori B. Tucker and Jane G. Schaller
DOI: 10.1016/s0022-3476(06)80111-3
02/1993

Systemic lupus erythematosus, dermatomyositis, scleroderma, vasculopathies, and other connective tissue disorders in children
Current Opinion in Rheumatology
Lori B. Tucker
DOI: 10.1097/00002281-199110000-00016
10/1991

Postnatal progression from second- to third-degree heart block in neonatal lupus syndrome
The Journal of Pediatrics
Robert L. Geggel and Lori Tucker and Jlona Szer
DOI: 10.1016/s0022-3476(88)80581-x
1988

Antiphospholipid Syndrome in Children
Hughes Syndrome
Lori B. Tucker and Rolando Cimaz
DOI: 10.1007/1-84628-009-5_20

Research

Promoting successful transition from pediatric rheumatology care to adult care for youth with chronic rheumatic diseases:
I am a collaborator on several projects aimed at development and testing of transition resources for youth and younger children with JIA or other rheumatic diseases. Our research group is currently doing a randomized controlled trial of a youth on line self management website called Teens Taking Charge, aimed at youth with JIA. We are in the development phase for a similar self management program for younger children with JIA and their parents. We are also starting final testing of a transition questionnaire called RACER (Readiness for Adult Care in Rheumatology), which will be tested in a number of Canadian pediatric rheumatology centres.

LEAP: Linking Exercise, Activity and Pathophysiology in Canadian Children with Arthritis: A Pan-Canadian Team:
I am a co-nominated Principal Investigator on this pan-Canadian project studying physical activity in children with JIA. Our project aims are to study the determinants of physical activity in children with JIA, to examine variables that predict PA in these patients, and to determine how PA influences clinical outcomes, inflammatory biomarkers, and the development of bone and muscle in children with JIA. The project involves 12 pediatric rheumatology centres across Canada and we have enrolled nearly 500 children and youth with JIA into a 2 year longitudinal study, looking at their level of PA over time as well as clinical, inflammatory, bone and muscle parameters. In addition, we are performing a novel pilot exercise intervention study, looking at new ways to encourage increased targeted activity in children with JIA that is safe and effective as well as fun.

ReACCH-Out: Research on Arthritis in Canadian Children, Emphasizing Outcomes: a Canadian multi-centre collaborative outcomes study
I am one of four principal investigators for this seminal CIHR-funded NET project, in which our pediatric rheumatology research program in Canada enrolled 1,500 newly diagnosed children with JIA into a longitudinal registry. This project has resulted in 6 publications to date and a number more in preparation, and is providing us with important data demonstrating the trajectory of JIA using modern treatments, prediction of disease course using disease features from early in disease, evaluation of pain over the course of JIA, incidence and prevalence of JIA-associated uveitis, as well as other areas of research. This project has provided the infrastructure to allow CAPRI to obtain funding and move forward to establish a long-lasting Canadian JIA registry.

Research Group Members

Maria Clarissa Belen, Research Assistant
Felice Mizan, Research Coordinator
Angelyne Rivera, Research Manager , Research Manager