Michael Anglesio

PhD

Affiliate Investigator, BC Children's Hospital
Associate Member, Department of Pathology and Laboratory Medicine, University of British Columbia
Member, Women's Health Research Institute
Member, Gynecological Cancer Initiative
Co-Founder, Molecular and Advanced Pathology Core, Department of Pathology and Laboratory Medicine, University of British Columbia

Dr. Anglesio's research has focused primarily on defining subtypes of ovarian cancer. In particular, genomic and protein-based biomarker studies that differentiate types and subtypes of each ovarian cancer histology. Most recently he has been focused on uncovering the mechanism through which endometriosis may become malignant and progress into either clear cell or endometrioid ovarian cancer. In 2017 Dr. Anglesio's group was first to provide evidence that roughly 1/3 of endometriosis frequently harbours cancer-driver mutations, and that these mutations are restricted to only one of two cell types that make up endometriosis.

Academic Affiliations

  • Assistant Professor, , Department of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia
  • Research Theme: Healthy Starts
  • Research Group(s): Origins of Child Health and Disease; Pathways to Healthy Birth

Contact Information

Location

Room 275, 2660 Oak Street, Vancouver, British Columbia, Canada, V6H 3Z6

Table 2 from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher and Kylie L. Gorringe and Matthew Wakefield and Adelyn Bolithon and Chi Nam Ignatius Pang and Derek S. Chiu and Michael S. Anglesio and Kylie-Ann Mallitt and Jennifer A. Doherty and Holly R. Harris and Joellen M. Schildkraut and Andrew Berchuck and Kara L. Cushing-Haugen and Ksenia Chezar and Angela Chou and Adeline Tan and Jennifer Alsop and Ellen Barlow and Matthias W. Beckmann and Jessica Boros and David D.L. Bowtell and Alison H. Brand and James D. Brenton and Ian Campbell and Dane Cheasley and Joshua Cohen and Cezary Cybulski and Esther Elishaev and Ramona Erber and Rhonda Farrell and Anna Fischer and Zhuxuan Fu and Blake Gilks and Anthony J. Gill and Charlie Gourley and Marcel Grube and Paul R. Harnett and Arndt Hartmann and Anusha Hettiaratchi and Claus K. Hgdall and Tomasz Huzarski and Anna Jakubowska and Mercedes Jimenez-Linan and Catherine J. Kennedy and Byoung-Gie Kim and Jae-Weon Kim and Jae-Hoon Kim and Kayla Klett and Jennifer M. Koziak and Tiffany Lai

DOI: 10.1158/1078-0432.30706335

11 / 2025

Supplementary Methods 1 from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher and Kylie L. Gorringe and Matthew Wakefield and Adelyn Bolithon and Chi Nam Ignatius Pang and Derek S. Chiu and Michael S. Anglesio and Kylie-Ann Mallitt and Jennifer A. Doherty and Holly R. Harris and Joellen M. Schildkraut and Andrew Berchuck and Kara L. Cushing-Haugen and Ksenia Chezar and Angela Chou and Adeline Tan and Jennifer Alsop and Ellen Barlow and Matthias W. Beckmann and Jessica Boros and David D.L. Bowtell and Alison H. Brand and James D. Brenton and Ian Campbell and Dane Cheasley and Joshua Cohen and Cezary Cybulski and Esther Elishaev and Ramona Erber and Rhonda Farrell and Anna Fischer and Zhuxuan Fu and Blake Gilks and Anthony J. Gill and Charlie Gourley and Marcel Grube and Paul R. Harnett and Arndt Hartmann and Anusha Hettiaratchi and Claus K. Hgdall and Tomasz Huzarski and Anna Jakubowska and Mercedes Jimenez-Linan and Catherine J. Kennedy and Byoung-Gie Kim and Jae-Weon Kim and Jae-Hoon Kim and Kayla Klett and Jennifer M. Koziak and Tiffany Lai

DOI: 10.1158/1078-0432.30706353

11 / 2025

Supplementary Figures S1-S13 from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher and Kylie L. Gorringe and Matthew Wakefield and Adelyn Bolithon and Chi Nam Ignatius Pang and Derek S. Chiu and Michael S. Anglesio and Kylie-Ann Mallitt and Jennifer A. Doherty and Holly R. Harris and Joellen M. Schildkraut and Andrew Berchuck and Kara L. Cushing-Haugen and Ksenia Chezar and Angela Chou and Adeline Tan and Jennifer Alsop and Ellen Barlow and Matthias W. Beckmann and Jessica Boros and David D.L. Bowtell and Alison H. Brand and James D. Brenton and Ian Campbell and Dane Cheasley and Joshua Cohen and Cezary Cybulski and Esther Elishaev and Ramona Erber and Rhonda Farrell and Anna Fischer and Zhuxuan Fu and Blake Gilks and Anthony J. Gill and Charlie Gourley and Marcel Grube and Paul R. Harnett and Arndt Hartmann and Anusha Hettiaratchi and Claus K. Hgdall and Tomasz Huzarski and Anna Jakubowska and Mercedes Jimenez-Linan and Catherine J. Kennedy and Byoung-Gie Kim and Jae-Weon Kim and Jae-Hoon Kim and Kayla Klett and Jennifer M. Koziak and Tiffany Lai

DOI: 10.1158/1078-0432.30706356

11 / 2025

Figure 1 from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher and Kylie L. Gorringe and Matthew Wakefield and Adelyn Bolithon and Chi Nam Ignatius Pang and Derek S. Chiu and Michael S. Anglesio and Kylie-Ann Mallitt and Jennifer A. Doherty and Holly R. Harris and Joellen M. Schildkraut and Andrew Berchuck and Kara L. Cushing-Haugen and Ksenia Chezar and Angela Chou and Adeline Tan and Jennifer Alsop and Ellen Barlow and Matthias W. Beckmann and Jessica Boros and David D.L. Bowtell and Alison H. Brand and James D. Brenton and Ian Campbell and Dane Cheasley and Joshua Cohen and Cezary Cybulski and Esther Elishaev and Ramona Erber and Rhonda Farrell and Anna Fischer and Zhuxuan Fu and Blake Gilks and Anthony J. Gill and Charlie Gourley and Marcel Grube and Paul R. Harnett and Arndt Hartmann and Anusha Hettiaratchi and Claus K. Hgdall and Tomasz Huzarski and Anna Jakubowska and Mercedes Jimenez-Linan and Catherine J. Kennedy and Byoung-Gie Kim and Jae-Weon Kim and Jae-Hoon Kim and Kayla Klett and Jennifer M. Koziak and Tiffany Lai

DOI: 10.1158/1078-0432.30706371

11 / 2025

Table 3 from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher and Kylie L. Gorringe and Matthew Wakefield and Adelyn Bolithon and Chi Nam Ignatius Pang and Derek S. Chiu and Michael S. Anglesio and Kylie-Ann Mallitt and Jennifer A. Doherty and Holly R. Harris and Joellen M. Schildkraut and Andrew Berchuck and Kara L. Cushing-Haugen and Ksenia Chezar and Angela Chou and Adeline Tan and Jennifer Alsop and Ellen Barlow and Matthias W. Beckmann and Jessica Boros and David D.L. Bowtell and Alison H. Brand and James D. Brenton and Ian Campbell and Dane Cheasley and Joshua Cohen and Cezary Cybulski and Esther Elishaev and Ramona Erber and Rhonda Farrell and Anna Fischer and Zhuxuan Fu and Blake Gilks and Anthony J. Gill and Charlie Gourley and Marcel Grube and Paul R. Harnett and Arndt Hartmann and Anusha Hettiaratchi and Claus K. Hgdall and Tomasz Huzarski and Anna Jakubowska and Mercedes Jimenez-Linan and Catherine J. Kennedy and Byoung-Gie Kim and Jae-Weon Kim and Jae-Hoon Kim and Kayla Klett and Jennifer M. Koziak and Tiffany Lai

DOI: 10.1158/1078-0432.30706332

11 / 2025

Table 1 from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher and Kylie L. Gorringe and Matthew Wakefield and Adelyn Bolithon and Chi Nam Ignatius Pang and Derek S. Chiu and Michael S. Anglesio and Kylie-Ann Mallitt and Jennifer A. Doherty and Holly R. Harris and Joellen M. Schildkraut and Andrew Berchuck and Kara L. Cushing-Haugen and Ksenia Chezar and Angela Chou and Adeline Tan and Jennifer Alsop and Ellen Barlow and Matthias W. Beckmann and Jessica Boros and David D.L. Bowtell and Alison H. Brand and James D. Brenton and Ian Campbell and Dane Cheasley and Joshua Cohen and Cezary Cybulski and Esther Elishaev and Ramona Erber and Rhonda Farrell and Anna Fischer and Zhuxuan Fu and Blake Gilks and Anthony J. Gill and Charlie Gourley and Marcel Grube and Paul R. Harnett and Arndt Hartmann and Anusha Hettiaratchi and Claus K. Hgdall and Tomasz Huzarski and Anna Jakubowska and Mercedes Jimenez-Linan and Catherine J. Kennedy and Byoung-Gie Kim and Jae-Weon Kim and Jae-Hoon Kim and Kayla Klett and Jennifer M. Koziak and Tiffany Lai

DOI: 10.1158/1078-0432.30706344

11 / 2025

Supplementary Tables S1-S11 from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher and Kylie L. Gorringe and Matthew Wakefield and Adelyn Bolithon and Chi Nam Ignatius Pang and Derek S. Chiu and Michael S. Anglesio and Kylie-Ann Mallitt and Jennifer A. Doherty and Holly R. Harris and Joellen M. Schildkraut and Andrew Berchuck and Kara L. Cushing-Haugen and Ksenia Chezar and Angela Chou and Adeline Tan and Jennifer Alsop and Ellen Barlow and Matthias W. Beckmann and Jessica Boros and David D.L. Bowtell and Alison H. Brand and James D. Brenton and Ian Campbell and Dane Cheasley and Joshua Cohen and Cezary Cybulski and Esther Elishaev and Ramona Erber and Rhonda Farrell and Anna Fischer and Zhuxuan Fu and Blake Gilks and Anthony J. Gill and Charlie Gourley and Marcel Grube and Paul R. Harnett and Arndt Hartmann and Anusha Hettiaratchi and Claus K. Hgdall and Tomasz Huzarski and Anna Jakubowska and Mercedes Jimenez-Linan and Catherine J. Kennedy and Byoung-Gie Kim and Jae-Weon Kim and Jae-Hoon Kim and Kayla Klett and Jennifer M. Koziak and Tiffany Lai

DOI: 10.1158/1078-0432.30706347

11 / 2025

Figure 3 from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher and Kylie L. Gorringe and Matthew Wakefield and Adelyn Bolithon and Chi Nam Ignatius Pang and Derek S. Chiu and Michael S. Anglesio and Kylie-Ann Mallitt and Jennifer A. Doherty and Holly R. Harris and Joellen M. Schildkraut and Andrew Berchuck and Kara L. Cushing-Haugen and Ksenia Chezar and Angela Chou and Adeline Tan and Jennifer Alsop and Ellen Barlow and Matthias W. Beckmann and Jessica Boros and David D.L. Bowtell and Alison H. Brand and James D. Brenton and Ian Campbell and Dane Cheasley and Joshua Cohen and Cezary Cybulski and Esther Elishaev and Ramona Erber and Rhonda Farrell and Anna Fischer and Zhuxuan Fu and Blake Gilks and Anthony J. Gill and Charlie Gourley and Marcel Grube and Paul R. Harnett and Arndt Hartmann and Anusha Hettiaratchi and Claus K. Hgdall and Tomasz Huzarski and Anna Jakubowska and Mercedes Jimenez-Linan and Catherine J. Kennedy and Byoung-Gie Kim and Jae-Weon Kim and Jae-Hoon Kim and Kayla Klett and Jennifer M. Koziak and Tiffany Lai

DOI: 10.1158/1078-0432.30706362

11 / 2025

Figure 2 from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher and Kylie L. Gorringe and Matthew Wakefield and Adelyn Bolithon and Chi Nam Ignatius Pang and Derek S. Chiu and Michael S. Anglesio and Kylie-Ann Mallitt and Jennifer A. Doherty and Holly R. Harris and Joellen M. Schildkraut and Andrew Berchuck and Kara L. Cushing-Haugen and Ksenia Chezar and Angela Chou and Adeline Tan and Jennifer Alsop and Ellen Barlow and Matthias W. Beckmann and Jessica Boros and David D.L. Bowtell and Alison H. Brand and James D. Brenton and Ian Campbell and Dane Cheasley and Joshua Cohen and Cezary Cybulski and Esther Elishaev and Ramona Erber and Rhonda Farrell and Anna Fischer and Zhuxuan Fu and Blake Gilks and Anthony J. Gill and Charlie Gourley and Marcel Grube and Paul R. Harnett and Arndt Hartmann and Anusha Hettiaratchi and Claus K. Hgdall and Tomasz Huzarski and Anna Jakubowska and Mercedes Jimenez-Linan and Catherine J. Kennedy and Byoung-Gie Kim and Jae-Weon Kim and Jae-Hoon Kim and Kayla Klett and Jennifer M. Koziak and Tiffany Lai

DOI: 10.1158/1078-0432.30706368

11 / 2025

Supplementary Table 1 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer

Fabian Coscia and Annelaura B. Nielsen and Melanie Weigert and Karen Watters and Melissa Javellana and Michael Anglesio and S. Diane Yamada and Ricardo R. Lastra and Matthias Mann and Ernst Lengyel

DOI: 10.1158/1078-0432.29221496

06 / 2025

Supplementary Figures and Legends 1 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer

Fabian Coscia and Annelaura B. Nielsen and Melanie Weigert and Karen Watters and Melissa Javellana and Michael Anglesio and S. Diane Yamada and Ricardo R. Lastra and Matthias Mann and Ernst Lengyel

DOI: 10.1158/1078-0432.29221499

06 / 2025

Supplementary Table 3 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer

Fabian Coscia and Annelaura B. Nielsen and Melanie Weigert and Karen Watters and Melissa Javellana and Michael Anglesio and S. Diane Yamada and Ricardo R. Lastra and Matthias Mann and Ernst Lengyel

DOI: 10.1158/1078-0432.29221490

06 / 2025

Supplementary Table 6 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer

Fabian Coscia and Annelaura B. Nielsen and Melanie Weigert and Karen Watters and Melissa Javellana and Michael Anglesio and S. Diane Yamada and Ricardo R. Lastra and Matthias Mann and Ernst Lengyel

DOI: 10.1158/1078-0432.29221481

06 / 2025

Supplementary Table 2 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer

Fabian Coscia and Annelaura B. Nielsen and Melanie Weigert and Karen Watters and Melissa Javellana and Michael Anglesio and S. Diane Yamada and Ricardo R. Lastra and Matthias Mann and Ernst Lengyel

DOI: 10.1158/1078-0432.29221493

06 / 2025

Supplementary Table 5 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer

Fabian Coscia and Annelaura B. Nielsen and Melanie Weigert and Karen Watters and Melissa Javellana and Michael Anglesio and S. Diane Yamada and Ricardo R. Lastra and Matthias Mann and Ernst Lengyel

DOI: 10.1158/1078-0432.29221484

06 / 2025

Data from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer

Fabian Coscia and Annelaura B. Nielsen and Melanie Weigert and Karen Watters and Melissa Javellana and Michael Anglesio and S. Diane Yamada and Ricardo R. Lastra and Matthias Mann and Ernst Lengyel

DOI: 10.1158/1078-0432.c.7854080

06 / 2025

Supplementary Table 4 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer

Fabian Coscia and Annelaura B. Nielsen and Melanie Weigert and Karen Watters and Melissa Javellana and Michael Anglesio and S. Diane Yamada and Ricardo R. Lastra and Matthias Mann and Ernst Lengyel

DOI: 10.1158/1078-0432.29221487

06 / 2025

A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer

Clinical Cancer Research

Fabian Coscia and Annelaura B. Nielsen and Melanie Weigert and Karen Watters and Melissa Javellana and Michael Anglesio and S. Diane Yamada and Ricardo R. Lastra and Matthias Mann and Ernst Lengyel

DOI: 10.1158/1078-0432.CCR-24-1763

06 / 2025

Cellular origins of mucinous ovarian carcinoma

The Journal of Pathology

Nicola S Meagher and Martin Kbel and Anthony N Karnezis and Aline Talhouk and Michael S Anglesio and Andrew Berchuck and Simon A Gayther and Paul PD Pharoah and Penelope M Webb and Susan J Ramus and Kylie L Gorringe

DOI: 10.1002/path.6407

05 / 2025

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy with Comorbid Traits

Soledad Ochoa and Fernanda S. Rasquel-Oliveira and Brett McKinnon and Marcela Haro and Sugarniya Subramaniam and Pak Yu and Simon Coetzee and Michael S. Anglesio and Kelly N. Wright and Raanan Meyer and Caroline E. Gargett and Sally Mortlock and Grant W. Montgomery and Michael S. Rogers and Kate Lawrenson

DOI: 10.1101/2024.11.21.624726

11 / 2024

Data from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher and Kylie L. Gorringe and Matthew Wakefield and Adelyn Bolithon and Chi Nam Ignatius Pang and Derek S. Chiu and Michael S. Anglesio and Kylie-Ann Mallitt and Jennifer A. Doherty and Holly R. Harris and Joellen M. Schildkraut and Andrew Berchuck and Kara L. Cushing-Haugen and Ksenia Chezar and Angela Chou and Adeline Tan and Jennifer Alsop and Ellen Barlow and Matthias W. Beckmann and Jessica Boros and David D.L. Bowtell and Alison H. Brand and James D. Brenton and Ian Campbell and Dane Cheasley and Joshua Cohen and Cezary Cybulski and Esther Elishaev and Ramona Erber and Rhonda Farrell and Anna Fischer and Zhuxuan Fu and Blake Gilks and Anthony J. Gill and Charlie Gourley and Marcel Grube and Paul R. Harnett and Arndt Hartmann and Anusha Hettiaratchi and Claus K. Hgdall and Tomasz Huzarski and Anna Jakubowska and Mercedes Jimenez-Linan and Catherine J. Kennedy and Byoung-Gie Kim and Jae-Weon Kim and Jae-Hoon Kim and Kayla Klett and Jennifer M. Koziak and Tiffany Lai

DOI: 10.1158/1078-0432.c.6532782

04 / 2023

CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study

Cancer

DOI: 10.1002/CNCR.34582

KRAS mutations and endometriosis burden of disease

Journal of Pathology Clinical Research

DOI: 10.1002/CJP2.317

Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study

British Journal of Cancer

DOI: 10.1038/S41416-022-02014-Y

Methylation Signature Implicated in Immuno-Suppressive Activities in Tubo-Ovarian High-Grade Serous Carcinoma

Cancer Epidemiology Biomarkers & Prevention

DOI: 10.1158/1055-9965.EPI-22-0941

Single-cell transcriptomic analysis of endometriosis

Nature Genetics

DOI: 10.1038/S41588-022-01254-1

Immunohistochemical Profiles Including p53, MMR, PR and CTNNB1 are Associated with Survival of Patients Diagnosed with Ovarian Endometrioid Carcinoma

Modern Pathology

The proteome of clear cell ovarian carcinoma

The Journal of Pathology

DOI: 10.1002/PATH.6006

Selection of endometrial carcinomas for p53 immunohistochemistry based on nuclear features

Journal of Pathology Clinical Research

DOI: 10.1002/CJP2.243

Molecular Subclasses of Clear Cell Ovarian Carcinoma and Their Impact on Disease Behavior and Outcomes

Clinical Cancer Research

DOI: 10.1158/1078-0432.CCR-21-3817

Metastasis in endometriosis: targeted sequencing suggests non-malignancy associated endometriosis is capable of wide dissemination

Geburtshilfe und Frauenheilkunde

DOI: 10.1055/S-0042-1756999

MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma

Virchows Archiv

DOI: 10.1007/S00428-021-03232-0

Molecular analysis suggests oligoclonality and metastasis of endometriosis lesions across anatomically defined subtypes

Fertility and Sterility

DOI: 10.1016/J.FERTNSTERT.2022.05.030

Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8+ TIL infiltration, and provides no independent prognostic value in endometriosis-associated ovarian carcinomas

The Journal of Pathology

DOI: 10.1002/PATH.5849

Multisite gynecologic endometrioid adenocarcinomas: Can mutation profiling be used to distinguish synchronous primary cancers from metastases?

Gynecologic Oncology Reports

DOI: 10.1016/J.GORE.2022.101076

Multi-modal immune profiling of mucinous ovarian carcinoma: analysis from the Ovarian Tumor Tissue Analysis/Multidisciplinary Ovarian Cancer Outcomes Group consortia

The Journal of Immunology

DOI: 10.4049/JIMMUNOL.208.SUPP.179.04

Prognostic and Theranostic Biomarkers in Ovarian Clear Cell Carcinoma

International Journal of Gynecological Pathology

DOI: 10.1097/PGP.0000000000000780

LYMPHADENECTOMY IN ENDOMETRIOID OVARIAN CARCINOMA PATIENTS WITH EARLY STAGE DISEASE: RESULTS FROM THE LEOPARD TRIAL

International Journal of Gynecological Cancer

DOI: 10.1136/IJGC-2022-IGCS.33

Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Clinical Cancer Research

DOI: 10.1158/1078-0432.CCR-22-1206

Into the future: A pilot study combining imaging with molecular profiling to predict resectability in ovarian cancer

Gynecologic Oncology

DOI: 10.1016/J.YGYNO.2022.07.020

Somatic Genomic Events in Endometriosis: Review of the Literature and Approach to Phenotyping

Reproductive Sciences

Paul J. Yong and Aline Talhouk and Michael S. Anglesio

DOI: 10.1007/s43032-020-00451-9

10 / 2021

Pathogenesis of bowel endometriosis

Best Practice & Research Clinical Obstetrics & Gynaecology

Paul J. Yong and Mohamed A. Bedaiwy and Fahad Alotaibi and Michael S. Anglesio

DOI: 10.1016/j.bpobgyn.2020.05.009

03 / 2021

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Modern Pathology

DOI: 10.1038/S41379-020-0618-9

NUCLEAR FEATURES ALLOW FOR HIGHLY SENSITIVE SELECTION OF ENDOMETRIAL CARCINOMAS FOR P53 TESTING

International Journal of Gynecological Cancer

DOI: 10.1136/IJGC-2021-IGCS.173

Pattern of invasion in stage I mucinous ovarian cancer is prognostic within 2-years of diagnosis

Asia-Pacific Journal of Clinical Oncology

Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer

Journal of Cancer Research and Clinical Oncology

DOI: 10.1007/S00432-021-03558-X

Prognostic and theragnostic biomarkers in ovarian clear cell carcinoma

Katharina Wiedemeyer and Linyuan Wang and Eun Young Kang and Shuhong Liu and Young Ou and Linda E. Kelemen and Lukas Feil and Michael S. Anglesio and Sarah Glaze and Prafull Ghatage and Gregg S. Nelson and Martin Kbel

DOI: 10.1101/2020.08.21.20178830

08 / 2020

Histotype-specific analysis of acid ceramidase expression in ovarian cancer

Virchows Archiv

DOI: 10.1007/S00428-019-02728-0

The Ovarian Tumour Tissue Analysis Consortium: Stratified Prognosis of Ovarian Tumors (OTTA-SPOT) signature for high-grade serous ovarian cancer

Clinical Cancer Research

ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation

Cell Reports

DOI: 10.1016/J.CELREP.2020.108366

Application of the molecular Risk Stratification of the Endometrium to endometrioid Ovarian Carcinoma - a retrospective, international Multicenter Study

Geburtshilfe und Frauenheilkunde

DOI: 10.1055/S-0040-1718219

Is endometriosis metastasizing? Shared somatic alterations suggest common origins across endometriotic lesions

Geburtshilfe und Frauenheilkunde

DOI: 10.1055/S-0040-1718045

Endometrial cancer molecular risk stratification in endometrioid ovarian cancers: A novel application of precision medicine

Clinical Cancer Research

Changes in the Tumor Immune Microenvironment during Disease Progression in Patients with Ovarian Cancer

Cancers

DOI: 10.3390/CANCERS12123828

Endometrial Cancer Molecular Risk Stratification is Equally Prognostic for Endometrioid Ovarian Carcinoma

Clinical Cancer Research

DOI: 10.1158/1078-0432.CCR-20-1268

Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)

Clinical Cancer Research

DOI: 10.1158/1078-0432.CCR-20-0103

STUDY IN PROGRESS: INTERNATIONAL RETROSPECTIVE STUDY ON LYMPHADENECTOMY IN ENDOMETRIOID OVARIAN CARCINOMA PATIENTS WITH EARLY STAGE DISEASE (LEOPARD)

International Journal of Gynecological Cancer

DOI: 10.1136/IJGC-2020-IGCS.394

Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival

Gynecologic Oncology

DOI: 10.1016/J.YGYNO.2020.06.481

Immunohistochemical Expression of L1CAM in Endometrioid Ovarian Cancer - A new Prognostic Marker?

Geburtshilfe und Frauenheilkunde

DOI: 10.1055/S-0040-1718139

Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium

British Journal of Cancer

DOI: 10.1038/S41416-020-0900-0

Molecular stratification of clear cell ovarian carcinomas

Geburtshilfe und Frauenheilkunde

DOI: 10.1055/S-0040-1718135

PrOTYPE (Predictor of high-grade-serous Ovarian carcinoma molecular subTYPE): The development and validation of a clinical-grade consensus classifier for the molecular subtypes of high-grade serous tubo-ovarian cancer

Clinical Cancer Research

DOI: 10.1158/1557-3265.OVCA19-A03

Prognostic gene expression signature for high-grade serous ovarian cancer

Annals of Oncology

DOI: 10.1016/J.ANNONC.2020.05.019

The molecular origin and taxonomy of mucinous ovarian carcinoma

Nature Communications

Dane Cheasley and Matthew J. Wakefield and Georgina L. Ryland and Prue E. Allan and Kathryn Alsop and Kaushalya C. Amarasinghe and Sumitra Ananda and Michael S. Anglesio and George Au-Yeung and Maret Bhm and David D. L. Bowtell and Alison Brand and Georgia Chenevix-Trench and Michael Christie and Yoke-Eng Chiew and Michael Churchman and Anna DeFazio and Renee Demeo and Rhiannon Dudley and Nicole Fairweather and Clare G. Fedele and Sian Fereday and Stephen B. Fox and C Blake Gilks and Charlie Gourley and Neville F. Hacker and Alison M. Hadley and Joy Hendley and Gwo-Yaw Ho and Siobhan Hughes and David G. Hunstman and Sally M. Hunter and Tom W. Jobling and Kimberly R. Kalli and Scott H. Kaufmann and Catherine J. Kennedy and Martin Kbel and Cecile Le Page and Jason Li and Richard Lupat and Orla M. McNally and Jessica N. McAlpine and Anne-Marie Mes-Masson and Linda Mileshkin and Diane M. Provencher and Jan Pyman and Kurosh Rahimi and Simone M. Rowley and Carolina Salazar and Goli Samimi

DOI: 10.1038/s41467-019-11862-x

09 / 2019

Molecular Classification of Epithelial Ovarian Cancer Based on Methylation Profiling: Evidence for Survival Heterogeneity

Clinical Cancer Research

DOI: 10.1158/1078-0432.CCR-18-3720

TRANSLATING ENDOMETRIAL MOLECULAR RISK STRATIFICATION TO ENDOMETRIOID OVARIAN CARCINOMA: A NOVEL APPLICATION OF PRECISION MEDICINE

International Journal of Gynecological Cancer

DOI: 10.1136/IJGC-2019-IGCS.3

Oncogenic mutations in histologically normal endometrium: the new normal?

The Journal of Pathology

DOI: 10.1002/PATH.5314

APPLICATION OF PRECISION MEDICINE: CAN MOLECULAR RISK STRATIFICATION PROVIDE NEW MANAGEMENT OPTIONS FOR LOW STAGE ENDOMETRIOID OVARIAN CARCINOMA?

International Journal of Gynecological Cancer

DOI: 10.1136/IJGC-2019-ESGO.41

THE PROGNOSTIC IMPACT OF SPHINGOSINE-KINASE 1 EXPRESSION (SPHK1) ON OVARIAN CANCER

International Journal of Gynecological Cancer

DOI: 10.1136/IJGC-2019-ESGO.882

Iatrogenic endometriosis harbors somatic cancer-driver mutations

Human Reproduction

DOI: 10.1093/HUMREP/DEY332

Molecular Subtype Not Immune Response Drives Outcomes in Endometrial Carcinoma

Clinical Cancer Research

DOI: 10.1158/1078-0432.CCR-18-3241

HACE1 is a potential tumor suppressor in osteosarcoma

Cell Death and Disease

DOI: 10.1038/S41419-018-1276-4

A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases

Modern Pathology

DOI: 10.1038/S41379-019-0302-0

Prognostic and Immunological Significance of ARID1A Status in Endometriosis-Associated Ovarian Cancers

Laboratory Investigation

Fibroblast growth factor receptor 4 (FGFR4) as detected by immunohistochemistry is associated with postoperative residual disease in ovarian cancer

Journal of Cancer Research and Clinical Oncology

DOI: 10.1007/S00432-019-02986-0

Optimized molecular risk stratification for ovarian endometrioid carcinomas

Modern Pathology

Nuclear -catenin and CDX2 expression in ovarian endometrioid carcinoma identify patients with favourable outcome

Histopathology

DOI: 10.1111/HIS.13772

You won't believe this old test that does cheap single-cell mutation detection

The Journal of Pathology: Clinical Research

Martin Kbel and Michael S. Anglesio and James D. Brenton

DOI: 10.1002/cjp2.108

07 / 2018

Extrauterine high-grade serous carcinomas with bilateral adnexal involvement as the only two disease sites are clonal based on tp53 sequencing results: implications for biology, classification, and staging

Modern Pathology

Naveena Singh and Asma Faruqi and Friedrich Kommoss and W Glenn McCluggage and Giorgia Trevisan and Janine Senz and Amy Lum and C Blake Gilks and Michael Anglesio

DOI: 10.1038/modpathol.2017.159

04 / 2018

Cancer Associated Mutations in Eutopic Endometrium

Laboratory Investigation

Capturing L1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers as a way to track tumor development

Clinical Cancer Research

Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study

The Journal of Pathology: Clinical Research

DOI: 10.1002/CJP2.109

Somatic Cancer-Driver Alterations Among Benign Endometriosis Subtypes

Laboratory Investigation

Endometriosis and endometriosis-associated cancers: new insights into the molecular mechanisms of ovarian cancer development

Ecancermedicalscience

DOI: 10.3332/ECANCER.2018.803

A gene expression prognostic signature for overall survival in patients with high-grade serous ovarian cancer

Journal of Clinical Oncology

DOI: 10.1200/JCO.2018.36.15_SUPPL.5583

Histotype classification of ovarian carcinoma: A comparison of approaches

Gynecologic Oncology

DOI: 10.1016/J.YGYNO.2018.08.016

Disease Distribution in Low-stage Tubo-ovarian High-grade Serous Carcinoma (HGSC): Implications for Assigning Primary Site and FIGO Stage

International Journal of Gynecological Pathology

DOI: 10.1097/PGP.0000000000000429

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer

Cell

DOI: 10.1016/J.CELL.2018.03.073

CLINICAL AND MOLECULAR CHARACTERIZATION OF SYNCHRONOUS ENDOMETRIAL AND OVARIAN CARCINOMAS

International Journal of Gynecological Cancer

Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes

Nature Genetics

Yi Kan Wang and Ali Bashashati and Michael S Anglesio and Dawn R Cochrane and Diljot S Grewal and Gavin Ha and Andrew McPherson and Hugo M Horlings and Janine Senz and Leah M Prentice and Anthony N Karnezis and Daniel Lai and Mohamed R Aniba and Allen W Zhang and Karey Shumansky and Celia Siu and Adrian Wan and Melissa K McConechy and Hector Li-Chang and Alicia Tone and Diane Provencher and Manon de Ladurantaye and Hubert Fleury and Aikou Okamoto and Satoshi Yanagida and Nozomu Yanaihara and Misato Saito and Andrew J Mungall and Richard Moore and Marco A Marra and C Blake Gilks and Anne-Marie Mes-Masson and Jessica N McAlpine and Samuel Aparicio and David G Huntsman and Sohrab P Shah

DOI: 10.1038/ng.3849

06 / 2017

Cancer-Associated Mutations in Endometriosis without Cancer

New England Journal of Medicine

DOI: 10.1056/NEJMOA1614814

APELA promotes tumour growth and cell migration in ovarian cancer in a p53-dependent manner

Gynecologic Oncology

DOI: 10.1016/J.YGYNO.2017.10.016

Identical TP53 mutations provide evidence that late-recurring tubo-ovarian high-grade serous carcinomas do not represent new peritoneal primaries

Histopathology

DOI: 10.1111/HIS.13327

EXPRESSION OF ACID CERAMIDASE (ASAH1) AS A PROGNOSTIC FACTOR IN OVARIAN CANCER

International Journal of Gynecological Cancer

Clinical and genetic analysis of recurrent adult-type granulosa cell tumor of the ovary: Persistent preservation of heterozygous c.402C > G FOXL2 mutation

Plos One

DOI: 10.1371/JOURNAL.PONE.0178989

Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma

Molecular Cancer Research

DOI: 10.1158/1541-7786.MCR-16-0132

LINE-1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers

Gynecologic Oncology

DOI: 10.1016/J.YGYNO.2017.09.032

Enhanced GAB2 Expression Is Associated with Improved Survival in High-grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition (vol 14, pg 1495, 2015)

Molecular Cancer Therapeutics

DOI: 10.1158/1535-7163.MCT-17-0067

Confirmation of ProMisE: A Simple, Genomics-Based Clinical Classifier for Endometrial Cancer

Cancer

DOI: 10.1002/CNCR.30496

Endometriosis-associated Ovarian Cancers

Clinical Obstetrics and Gynecology

DOI: 10.1097/GRF.0000000000000320

Genomic consequences of aberrant DNA repair stratify ovarian cancer histotypes

Cancer Research

DOI: 10.1158/1538-7445.AM2016-LB-324

Synchronous ovarian and endometrial carcinomas: The case for pseudo-metastasis

Clinical Cancer Research

DOI: 10.1158/1557-3265.OVCA15-PR07

Single-Patient Molecular Testing with NanoString nCounter Data Using a Reference-Based Strategy for Batch Effect Correction

Plos One

DOI: 10.1371/JOURNAL.PONE.0153844

IS ENDOMETRIOSIS A NEOPLASM AND IS THERE AN OPPORTUNITY FOR A BIOLOGICALLY INFORMED CLASSIFICATION SYSTEM?

International Journal of Gynecological Cancer

Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver (vol 20, pg 6618, 2014)

Clinical Cancer Research

DOI: 10.1158/1078-0432.CCR-16-0992

Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality

Journal of the National Cancer Institute

DOI: 10.1093/JNCI/DJV428

Differences in MEK inhibitor efficacy in molecularly characterized low-grade serous ovarian cancer cell lines

American Journal of Cancer Research

Genomics analyses of less common epithelial ovarian cancer subtypes

Clinical Cancer Research

DOI: 10.1158/1557-3265.OVCA15-B08

BAF250a Expression in Atypical Endometriosis and Endometriosis-Associated Ovarian Cancer

International Journal of Gynecological Cancer

DOI: 10.1097/IGC.0000000000000698

Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden.

Anglesio MS and Bashashati A and Wang YK and Senz J and Ha G and Yang W and Aniba MR and Prentice LM and Farahani H and Li Chang H and Karnezis AN and Marra MA and Yong PJ and Hirst M and Gilks B and Shah SP and Huntsman DG

DOI: 10.1002/path.4516 PubMed: 25692284

06 / 2015

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition.

Davis SJ and Sheppard KE and Anglesio MS and George J and Traficante N and Fereday S and Intermaggio MP and Menon U and Gentry-Maharaj A and Lubinski J and Gronwald J and Pearce CL and Pike MC and Wu A and Kommoss S and Pfisterer J and du Bois A and Hilpert F and Ramus SJ and Bowtell DD and Huntsman DG and Pearson RB and Simpson KJ and Campbell IG and Gorringe KL

DOI: 10.1158/1535-7163.MCT-15-0039 PubMed: 25852062

06 / 2015

Recurrent DICER1 Hotspot Mutations in Endometrial Tumours And Their Impact on MicroRNA Biogenesis.

Chen J and Wang Y and McMonechy MK and Anglesio MS and Yang W and Senz J and Maines-Bandiera S and Rosner J and Trigo-Gonzalez G and Grace Cheng SW and Kim J and Matzuk MM and Morin GB and Huntsman DG

PubMed: 26033159

06 / 2015

The somatic mutational landscape of endometriosis associated ovarian cancers and precursor lesions

Clinical Cancer Research

DOI: 10.1158/1557-3265.OVCASYMP14-AS18

The Oncogenic Roles of DICER1 RNase IIIb Domain Mutations in Ovarian Sertoli-Leydig Cell Tumors

Neoplasia

DOI: 10.1016/J.NEO.2015.08.003

Morphologic and Molecular Characteristics of Mixed Epithelial Ovarian Cancers

American Journal of Surgical Pathology

DOI: 10.1097/PAS.0000000000000476

The oncogenic role of DICER1 RNase IIIb domain mutations in ovarian sertoli-leydig cell tumors

Clinical Cancer Research

DOI: 10.1158/1557-3265.OVCASYMP14-POSTER-BIOL-1349

Polymerase Epsilon Exonuclease Domain Mutations in Ovarian Endometrioid Carcinoma

International Journal of Gynecological Cancer

DOI: 10.1097/IGC.0000000000000492

Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes

Oncotarget

DOI: 10.18632/ONCOTARGET.5438

Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms.

Mackenzie R and Kommoss S and Winterhoff BJ and Kipp BR and Garcia JJ and Voss J and Halling K and Karnezis A and Senz J and Yang W and Prigge ES and Reuschenbach M and Doeberitz MV and Gilks BC and Huntsman DG and Bakkum-Gamez J and McAlpine JN and Anglesio MS

DOI: 10.1186/s12885-015-1421-8 PubMed: 25986173

Recurrent DICER1 hotspot mutations in endometrial tumours and their impact on microRNA biogenesis

The Journal of Pathology

DOI: 10.1002/PATH.4569

Molecular Characteristics of Mixed Ovarian Carcinomas

Modern Pathology

Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver.

Emmanuel C and Chiew YE and George J and Etemadmoghadam D and Anglesio MS and Sharma R and Russell P and Kennedy C and Fereday S and Hung J and Galletta L and Hogg R and Wain GV and Brand A and Balleine R and MacConaill L and Palescandolo E and Hunter SM and Campbell I and Dobrovic A and Wong SQ and Do H and Clarke CL and Harnett PR and Bowtell DD and deFazio A and Australian Ovarian Cancer Study (AOCS)

DOI: 10.1158/1078-0432.CCR-14-1292 PubMed: 25316818

12 / 2014

Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study.

Kbel M and Madore J and Ramus SJ and Clarke BA and Pharoah PD and Deen S and Bowtell DD and Odunsi K and Menon U and Morrison C and Lele S and Bshara W and Sucheston L and Beckmann MW and Hein A and Thiel FC and Hartmann A and Wachter DL and Anglesio MS and Hgdall E and Jensen A and Hgdall C and Kalli KR and Fridley BL and Keeney GL and Fogarty ZC and Vierkant RA and Liu S and Cho S and Nelson G and Ghatage P and Gentry-Maharaj A and Gayther SA and Benjamin E and Widschwendter M and Intermaggio MP and Rosen B and Bernardini MQ and Mackay H and Oza A and Shaw P and Jimenez-Linan M and Driver KE and Alsop J and Mack M and Koziak JM and Steed H and Ewanowich C and DeFazio A and Chenevix-Trench G and Fereday S and Gao B and Johnatty SE and George J and Galletta L and AOCS Study Group and Goode EL and Kjr SK and Huntsman DG and Fasching PA and Moysich KB and Brenton JD and Kelemen LE

DOI: 10.1038/bjc.2014.567 PubMed: 25349970

12 / 2014

Harnessing the potential of lipid-based nanomedicines for type-specific ovarian cancer treatments.

Leung AW and Kalra J and Santos ND and Bally MB and Anglesio MS

DOI: 10.2217/nnm.13.220 PubMed: 24746193

03 / 2014

A current perspective on the pathological assessment of FOXL2 in adult-type granulosa cell tumours of the ovary.

Kommoss S and Gilks CB and Penzel R and Herpel E and Mackenzie R and Huntsman D and Schirmacher P and Anglesio M and Schmidt D and Kommoss F

DOI: 10.1111/his.12253 PubMed: 24192202

02 / 2014

A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation.

Wiegand KC and Hennessy BT and Leung S and Wang Y and Ju Z and McGahren M and Kalloger SE and Finlayson S and Stemke-Hale K and Lu Y and Zhang F and Anglesio MS and Gilks B and Mills GB and Huntsman DG and Carey MS

DOI: 10.1186/1471-2407-14-120 PubMed: 24559118

PROGNOSTIC MARKERS FOR HIGH GRADE SEROUS OVARIAN CANCER AND VALIDATION USING LARGE SCALE NANOSTRING EXPRESSION PROFILING: AN OTTA CONSORTIUM STUDY

International Journal of Gynecological Cancer

Recurrent DICER1 hotspot mutations in endometrial cancer and their impact on microRNA biogenesis

Cancer Research

DOI: 10.1158/1538-7445.AM2014-544

ENHANCED GAB2 EXPRESSION IS CHARACTERISTIC OF A CLINICALLY DISTINCT PI3K-DEPENDENT SUBTYPE OF HIGH-GRADE SEROUS AND ENDOMETRIOID OVARIAN CANCER

International Journal of Gynecological Cancer

PRACTICAL TECHNOLOGIES FOR MOLECULAR-BASED CLASSIFICATION TO IMPROVE MANAGEMENT IN WOMEN WITH ENDOMETRIAL CANCER

International Journal of Gynecological Cancer

The somatic mutational landscape of ovarian clear cell carcinoma and its precursor lesions

Cancer Research

DOI: 10.1158/1538-7445.AM2014-LB-312

EXOME SEQUENCING OF LOW GRADE SEROUS OVARIAN TUMOURS

International Journal of Gynecological Cancer

Accelerating type-specific ovarian carcinoma research: Calculator for Ovarian Subtype Prediction (COSP) is a reliable high-throughput tool for case review.

Kommoss S and Gilks CB and Kommoss F and Chow C and Hilpert F and du Bois A and Kbel M and Huntsman DG and Anglesio M and Kalloger SE and Pfisterer J

DOI: 10.1111/his.12219 PubMed: 24033430

11 / 2013

Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling.

Bashashati A and Ha G and Tone A and Ding J and Prentice LM and Roth A and Rosner J and Shumansky K and Kalloger S and Senz J and Yang W and McConechy M and Melnyk N and Anglesio M and Luk MT and Tse K and Zeng T and Moore R and Zhao Y and Marra MA and Gilks B and Yip S and Huntsman DG and McAlpine JN and Shah SP

DOI: 10.1002/path.4230 PubMed: 23780408

09 / 2013

Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study.

Sieh W and Kbel M and Longacre TA and Bowtell DD and deFazio A and Goodman MT and Hgdall E and Deen S and Wentzensen N and Moysich KB and Brenton JD and Clarke BA and Menon U and Gilks CB and Kim A and Madore J and Fereday S and George J and Galletta L and Lurie G and Wilkens LR and Carney ME and Thompson PJ and Matsuno RK and Kjr SK and Jensen A and Hgdall C and Kalli KR and Fridley BL and Keeney GL and Vierkant RA and Cunningham JM and Brinton LA and Yang HP and Sherman ME and Garca-Closas M and Lissowska J and Odunsi K and Morrison C and Lele S and Bshara W and Sucheston L and Jimenez-Linan M and Driver K and Alsop J and Mack M and McGuire V and Rothstein JH and Rosen BP and Bernardini MQ and Mackay H and Oza A and Wozniak EL and Benjamin E and Gentry-Maharaj A and Gayther SA and Tinker AV and Prentice LM and Chow C and Anglesio MS and Johnatty SE and Chenevix-Trench G and Whittemore AS and Pharoah PD and Goode EL and Huntsman DG and Ramus SJ

DOI: 10.1016/S1470-2045(13)70253-5 PubMed: 23845225

08 / 2013

FOXL2 molecular testing in ovarian neoplasms: diagnostic approach and procedural guidelines.

Kommoss S and Anglesio MS and Mackenzie R and Yang W and Senz J and Ho J and Bell L and Lee S and Lorette J and Huntsman DG and Blake Gilks C

DOI: 10.1038/modpathol.2012.226 PubMed: 23348906

06 / 2013

Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage.

Anglesio MS and Wang Y and Yang W and Senz J and Wan A and Heravi-Moussavi A and Salamanca C and Maines-Bandiera S and Huntsman DG and Morin GB

DOI: 10.1002/path.4135 PubMed: 23132766

02 / 2013

Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas.

Anglesio MS and Kommoss S and Tolcher MC and Clarke B and Galletta L and Porter H and Damaraju S and Fereday S and Winterhoff BJ and Kalloger SE and Senz J and Yang W and Steed H and Allo G and Ferguson S and Shaw P and Teoman A and Garcia JJ and Schoolmeester JK and Bakkum-Gamez J and Tinker AV and Bowtell DD and Huntsman DG and Gilks CB and McAlpine JN

DOI: 10.1002/path.4088 PubMed: 22899400

01 / 2013

Correction: Type-Specific Cell Line Models for Type-Specific Ovarian Cancer Research.

Anglesio MS and Wiegand KC and Melnyk N and Chow C and Salamanca C and Prentice LM and Senz J and Yang W and Spillman MA and Cochrane DR and Shumansky K and Shah SP and Kalloger SE and Huntsman DG

PubMed: 24116245

Rapid RNA-based histotyping of ovarian carcinomas

Clinical Cancer Research

DOI: 10.1158/1078-0432.OVCA13-B14

Defining ovarian mucinous tumors: Cancer genes and heterogeneity

Clinical Cancer Research

DOI: 10.1158/1078-0432.OVCA13-A18

Type-specific cell line models for type-specific ovarian cancer research.

Anglesio MS and Wiegand KC and Melnyk N and Chow C and Salamanca C and Prentice LM and Senz J and Yang W and Spillman MA and Cochrane DR and Shumansky K and Shah SP and Kalloger SE and Huntsman DG

DOI: 10.1371/journal.pone.0072162 PubMed: 24023729

Markers of T cell infiltration and function associate with favorable outcome in vascularized high-grade serous ovarian carcinoma.

Townsend KN and Spowart JE and Huwait H and Eshragh S and West NR and Elrick MA and Kalloger SE and Anglesio M and Watson PH and Huntsman DG and Lum JJ

DOI: 10.1371/journal.pone.0082406 PubMed: 24376535

Molecular profiling of low grade serous ovarian tumors

Clinical Cancer Research

DOI: 10.1158/1078-0432.OVCA13-A13

A CURRENT PERSPECTIVE ON THE PATHOLOGICAL ASSESSMENT OF ADULT-TYPE GRANULOSA CELL TUMORS OF THE OVARY

International Journal of Gynecological Cancer

The ovarian tumor tissue analysis (OTTA) consortium

Clinical Cancer Research

DOI: 10.1158/1078-0432.OVCA13-A27

The autophagy protein LC3A correlates with hypoxia and is a prognostic marker of patient survival in clear cell ovarian cancer.

Spowart JE and Townsend KN and Huwait H and Eshragh S and West NR and Ries JN and Kalloger S and Anglesio M and Gorski SM and Watson PH and Gilks CB and Huntsman DG and Lum JJ

DOI: 10.1002/path.4090 PubMed: 22926683

12 / 2012

Cytokine gene expression signature in ovarian clear cell carcinoma.

Yanaihara N and Anglesio MS and Ochiai K and Hirata Y and Saito M and Nagata C and Iida Y and Takakura S and Yamada K and Tanaka T and Okamoto A

DOI: 10.3892/ijo.2012.1533 PubMed: 22751940

09 / 2012

LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin.

Cowin PA and George J and Fereday S and Loehrer E and Van Loo P and Cullinane C and Etemadmoghadam D and Ftouni S and Galletta L and Anglesio MS and Hendley J and Bowes L and Sheppard KE and Christie EL and Pearson RB and Harnett PR and Heinzelmann-Schwarz V and Friedlander M and McNally O and Quinn M and Campbell P and deFazio A and Bowtell DD and Australian Ovarian Cancer Study

DOI: 10.1158/0008-5472.CAN-12-0203 PubMed: 22896685

08 / 2012

Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers.

Heravi-Moussavi A and Anglesio MS and Cheng SW and Senz J and Yang W and Prentice L and Fejes AP and Chow C and Tone A and Kalloger SE and Hamel N and Roth A and Ha G and Wan AN and Maines-Bandiera S and Salamanca C and Pasini B and Clarke BA and Lee AF and Lee CH and Zhao C and Young RH and Aparicio SA and Sorensen PH and Woo MM and Boyd N and Jones SJ and Hirst M and Marra MA and Gilks B and Shah SP and Foulkes WD and Morin GB and Huntsman DG

DOI: 10.1056/NEJMoa1102903 PubMed: 22187960

01 / 2012

FOXL2 Molecular Testing in the Diagnosis of Ovarian Neoplasms

Laboratory Investigation

Benign serous ovarian tumour: a redefining moment?

Hunter S and Gorringe K and Anglesio M and Sharma R and Gilks B and deFazio A and Huntsman D and Campbell I

Copy number aberrations in benign serous ovarian tumors: a case for reclassification?

Hunter SM and Anglesio MS and Sharma R and Gilks CB and Melnyk N and Chiew YE and deFazio A and Australian Ovarian Cancer Study Group and Longacre TA and Huntsman DG and Gorringe KL and Campbell IG

DOI: 10.1158/1078-0432.CCR-11-2080 PubMed: 21976534

12 / 2011

Clear cell carcinoma of the ovary: a report from the first Ovarian Clear Cell Symposium, June 24th, 2010.

Anglesio MS and Carey MS and Kbel M and Mackay H and Huntsman DG and Vancouver Ovarian Clear Cell Symposium Speakers

DOI: 10.1016/j.ygyno.2011.01.005 PubMed: 21276610

05 / 2011

Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas.

McConechy MK and Anglesio MS and Kalloger SE and Yang W and Senz J and Chow C and Heravi-Moussavi A and Morin GB and Mes-Masson AM and Australian Ovarian Cancer Study Group and Carey MS and McAlpine JN and Kwon JS and Prentice LM and Boyd N and Shah SP and Gilks CB and Huntsman DG

DOI: 10.1002/path.2848 PubMed: 21381030

04 / 2011

IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer.

Anglesio MS and George J and Kulbe H and Friedlander M and Rischin D and Lemech C and Power J and Coward J and Cowin PA and House CM and Chakravarty P and Gorringe KL and Campbell IG and Australian Ovarian Cancer Study Group and Okamoto A and Birrer MJ and Huntsman DG and de Fazio A and Kalloger SE and Balkwill F and Gilks CB and Bowtell DD

DOI: 10.1158/1078-0432.CCR-10-3314 PubMed: 21343371

04 / 2011

Using the right tools: A catalog of ovarian cancer cell lines by subtype

Cancer Research

DOI: 10.1158/1538-7445.AM2011-4289

Identification of somatic mutations of the PPP2R1A gene in subtypes of endometrial and ovarian carcinomas

Cancer Research

DOI: 10.1158/1538-7445.AM2011-924

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.

Helland and Anglesio MS and George J and Cowin PA and Johnstone CN and House CM and Sheppard KE and Etemadmoghadam D and Melnyk N and Rustgi AK and Phillips WA and Johnsen H and Holm R and Kristensen GB and Birrer MJ and Australian Ovarian Cancer Study Group and Pearson RB and Brresen-Dale AL and Huntsman DG and deFazio A and Creighton CJ and Smyth GK and Bowtell DD

DOI: 10.1371/journal.pone.0018064 PubMed: 21533284

Benign ovarian serous tumors: A redefining moment

Cancer Research

DOI: 10.1158/1538-7445.AM2011-LB-271

ARID1A mutations in endometriosis-associated ovarian carcinomas.

Wiegand KC and Shah SP and Al-Agha OM and Zhao Y and Tse K and Zeng T and Senz J and McConechy MK and Anglesio MS and Kalloger SE and Yang W and Heravi-Moussavi A and Giuliany R and Chow C and Fee J and Zayed A and Prentice L and Melnyk N and Turashvili G and Delaney AD and Madore J and Yip S and McPherson AW and Ha G and Bell L and Fereday S and Tam A and Galletta L and Tonin PN and Provencher D and Miller D and Jones SJ and Moore RA and Morin GB and Oloumi A and Boyd N and Aparicio SA and Shih IeM and Mes-Masson AM and Bowtell DD and Hirst M and Gilks B and Marra MA and Huntsman DG

DOI: 10.1056/NEJMoa1008433 PubMed: 20942669

10 / 2010

Copy number analysis identifies novel interactions between genomic loci in ovarian cancer.

Gorringe KL and George J and Anglesio MS and Ramakrishna M and Etemadmoghadam D and Cowin P and Sridhar A and Williams LH and Boyle SE and Yanaihara N and Okamoto A and Urashima M and Smyth GK and Campbell IG and Bowtell DD and Australian Ovarian Cancer Study

DOI: 10.1371/journal.pone.0011408 PubMed: 20844748

Profiling the cancer genome.

Cowin PA and Anglesio M and Etemadmoghadam D and Bowtell DD

DOI: 10.1146/annurev-genom-082509-141536 PubMed: 20590430

Are there any more ovarian tumor suppressor genes? A new perspective using ultra high-resolution copy number and loss of heterozygosity analysis.

Gorringe KL and Ramakrishna M and Williams LH and Sridhar A and Boyle SE and Bearfoot JL and Li J and Anglesio MS and Campbell IG

DOI: 10.1002/gcc.20694 PubMed: 19603523

10 / 2009

A dysregulated pathway underlying a novel molecular subtype of ovarian cancer

European Journal of Cancer, Supplement

DOI: 10.1016/S1359-6349(09)70314-3

Mutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors.

Anglesio MS and Arnold JM and George J and Tinker AV and Tothill R and Waddell N and Simms L and Locandro B and Fereday S and Traficante N and Russell P and Sharma R and Birrer MJ and AOCS Study Group and deFazio A and Chenevix-Trench G and Bowtell DD

DOI: 10.1158/1541-7786.MCR-08-0193 PubMed: 19010816

11 / 2008

The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers.

Zhang L and Anglesio MS and O'Sullivan M and Zhang F and Yang G and Sarao R and Mai PN and Cronin S and Hara H and Melnyk N and Li L and Wada T and Liu PP and Farrar J and Arceci RJ and Sorensen PH and Penninger JM

DOI: 10.1038/nm1621 PubMed: 17694067

09 / 2007

Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.

Evdokimova V and Ruzanov P and Anglesio MS and Sorokin AV and Ovchinnikov LP and Buckley J and Triche TJ and Sonenberg N and Sorensen PH

DOI: 10.1128/MCB.26.1.277-292.2006 PubMed: 16354698

01 / 2006

Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney.

Anglesio MS and Evdokimova V and Melnyk N and Zhang L and Fernandez CV and Grundy PE and Leach S and Marra MA and Brooks-Wilson AR and Penninger J and Sorensen PH

DOI: 10.1093/hmg/ddh215 PubMed: 15254018

09 / 2004

Influence of "cancer driver" somatic mutation on the immune microenvironment of endometriosis and endoemtriosis-associated ovarian cancers

Prevelance of "cancer driver" somatic mutations in endometriosis subtypes, as well as the association of somatic mutations with clinical factors such as pain

Grants

CIHR Early Career Investigator Operating Grant: Endometriosis Microenvironment: Influence of "Cancer-Driver" Mutations

NIH R37 Project Grant (Co-Applicant): High-throughput Epigenomic Mapping of Regulatory Elements in Ovarian Cancer at Basepair Resolution

CIHR Project Grant (Co-Pl): Sexual Pain in Endometriosis: Role of Somatic Mutations and Local Neurogenesis

Honours & Awards

2016/5 - Department of Pathology and Laboratory Medicine Award for Excellence in Mentoring, University of British Columbia

2019/1- Most impactful paper published in 2017 from the Columbia Hospital for Women Research Foundation (CHWRF) with reference to: Anglesio et al. N Eng J Med 2017. Cancer-Associated Mutations in Endometriosis without Cancer

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