Overview

Respiratory

Over the last 15 years I have developed a research interest into non-CF Bronchiectasis. This focused primarily on primary ciliary dyskinesia. I developed a new method for the evaluation of function of the microscopic hairs (cilia) which line the airways of the lung. This has been standardized and now used as an accepted method for the diagnosis of primary ciliary dyskinesia and research platform.

Cystic Fibrosis

Cystic Fibrosis (CF) research is another significant research area. I am the PI on several clinical trials looking at new medications in CF patients.

I coordinate the CF clinic multidisciplinary research program and this is promoting research into nursing, physiotherapy, pharmacy and dietetic issues within CF. Current themes are transitional care to adulthood; physiotherapy interventions; location of CF care and outcome in adolescence and adherence to medication. We work closely with the adult CF clinic at St. Paul's on several joint projects.

Publications

Matrix-assisted laser desorption/ionization time-of-flight MS for the accurate identification of Burkholderia cepacia complex and Burkholderia gladioli in the clinical microbiology laboratory
Journal of Medical Microbiology
Kendrew S. K. Wong and Suk Dhaliwal and Jennifer Bilawka and Jocelyn A. Srigley and Sylvie Champagne and Marc G. Romney and Peter Tilley and Manish Sadarangani and James E. A. Zlosnik and Mark A. Chilvers
DOI: 10.1099/jmm.0.001223
08/2020

Performance of a Three-Tier (IRT-DNA-IRT) Cystic Fibrosis Screening Algorithm in British Columbia
International Journal of Neonatal Screening
Graham Sinclair and Vanessa McMahon and Amy Schellenberg and Tanya N. Nelson and Mark Chilvers and Hilary Vallance
DOI: 10.3390/ijns6020046
06/2020

Immunoreactive trypsinogen levels in newborn screened infants with an inconclusive diagnosis of cystic fibrosis.
BMC pediatrics
Ooi CY and Sutherland R and Castellani C and Keenan K and Boland M and Reisman J and Bjornson C and Chilvers MA and van Wylick R and Kent S and Price A and Mateos-Corral D and Hughes D and Gonska T
DOI: 10.1186/s12887-019-1756-4
PubMed: 31640630
10/2019

Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial
The Lancet Respiratory Medicine
DOI: 10.1016/s2213-2600(19)30187-0
09/2019

An investigation into biomarkers for the diagnosis of ABPA and aspergillus disease in cystic fibrosis.
Pediatric pulmonology
Keown K and Abbott S and Kuzeljevic B and Rayment JH and Chilvers MA and Yang CL
DOI: 10.1002/ppul.24465
PubMed: 31359612
07/2019

Ciliary functional analysis: Beating a path towards standardization.
Pediatric pulmonology
Kempeneers C and Seaton C and Garcia Espinosa B and Chilvers MA
DOI: 10.1002/ppul.24439
PubMed: 31313529
07/2019

A phase 3 study of tezacaftor in combination with ivacaftor in children aged 6 through 11¿years with cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Walker S and Flume P and McNamara J and Solomon M and Chilvers M and Chmiel J and Harris RS and Haseltine E and Stiles D and Li C and Ahluwalia N and Zhou H and Owen CA and Sawicki G and VX15-661-113 Investigator Group
DOI: 10.1016/j.jcf.2019.06.009
PubMed: 31253540
06/2019

An open-label extension study of ivacaftor in children with CF and a CFTR gating mutation initiating treatment at age 2-5¿years (KLIMB).
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Rosenfeld M and Cunningham S and Harris WT and Lapey A and Regelmann WE and Sawicki GS and Southern KW and Chilvers M and Higgins M and Tian S and Cooke J and Davies JC and KLIMB study group
DOI: 10.1016/j.jcf.2019.03.009
PubMed: 31053538
04/2019

Epidemiology of Clonal Pseudomonas aeruginosa Infection in a Canadian Cystic Fibrosis Population.
Annals of the American Thoracic Society
Middleton MA and Layeghifard M and Klingel M and Stanojevic S and Yau YCW and Zlosnik JEA and Coriati A and Ratjen FA and Tullis ED and Stephenson A and Wilcox P and Freitag A and Waters VJ
DOI: 10.1513/annalsats.201801-007oc
PubMed: 29911888
07/2018

To beat, or not to beat, that is question! The spectrum of ciliopathies
Pediatric Pulmonology
Céline Kempeneers and Mark A. Chilvers
DOI: 10.1002/ppul.24078
06/2018

Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline.
American journal of respiratory and critical care medicine
Shapiro AJ and Davis SD and Polineni D and Manion M and Rosenfeld M and Dell SD and Chilvers MA and Ferkol TW and Zariwala MA and Sagel SD and Josephson M and Morgan L and Yilmaz O and American Thoracic Society Assembly on Pediatrics
DOI: 10.1164/rccm.201805-0819st
PubMed: 29905515
06/2018

Epidemiology of clonal pseudomonas aeruginosa infection in a canadian cystic fibrosis population
Annals of the American Thoracic Society
Middleton, M.A. and Layeghifard, M. and Klingel, M. and Stanojevic, S. and Yau, Y.C.W. and Zlosnik, J.E.A. and Coriati, A. and Ratjen, F.A. and Tullis, E.D. and Stephenson, A. and Wilcox, P. and Freitag, A. and Chilvers, M. and McKinney, M. and Lavoie, A. and Wang, P.W. and Guttman, D.S. and Waters, V.J.
DOI: 10.1513/AnnalsATS.201801-007OC
2018

Efficacy and safety of lumacaftor and ivacaftor in patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial.
The Lancet. Respiratory medicine
Ratjen F and Hug C and Marigowda G and Tian S and Huang X and Stanojevic S and Milla CE and Robinson PD and Waltz D and Davies JC and VX14-809-109 investigator group
DOI: 10.1016/s2213-2600(17)30215-1
PubMed: 28606620
06/2017

Viral interference and the live-attenuated intranasal influenza vaccine: Results from a pediatric cohort with cystic fibrosis
Human Vaccines and Immunotherapeutics
Boikos, C. and Papenburg, J. and Martineau, C. and Joseph, L. and Scheifele, D. and Chilvers, M. and Lands, L.C. and De Serres, G. and Quach, C.
DOI: 10.1080/21645515.2017.1287641
2017

Adverse events following live-attenuated intranasal influenza vaccination of children with cystic fibrosis: Results from two influenza seasons
Vaccine
Boikos, C. and Joseph, L. and Scheifele, D. and Lands, L.C. and De Serres, G. and Papenburg, J. and Winters, N. and Chilvers, M. and Quach, C.
DOI: 10.1016/j.vaccine.2017.07.068
2017

Dornase alfa for cystic fibrosis
Paediatric Respiratory Reviews
Yang, C.L. and Chilvers, M. and Montgomery, M. and Nolan, S.J.
DOI: 10.1016/j.prrv.2016.09.001
2017

Response
Chest
Kempeneers, C. and Seaton, C. and Chilvers, M.A.
DOI: 10.1016/j.chest.2017.08.1177
2017

Variation of Ciliary Beat Pattern in Three Different Beating Planes in Healthy Subjects
Chest
Kempeneers, C. and Seaton, C. and Chilvers, M.A.
DOI: 10.1016/j.chest.2016.09.015
2017

Safety, pharmacokinetics, and pharmacodynamics of ivacaftor in patients aged 2-5 years with cystic fibrosis and a CFTR gating mutation (KIWI): an open-label, single-arm study.
The Lancet. Respiratory medicine
Davies JC and Cunningham S and Harris WT and Lapey A and Regelmann WE and Sawicki GS and Southern KW and Robertson S and Green Y and Cooke J and Rosenfeld M and KIWI Study Group
DOI: 10.1016/s2213-2600(15)00545-7
PubMed: 26803277
01/2016

Influenza virus detection following administration of live-attenuated intranasal influenza vaccine in children with cystic fibrosis and their healthy siblings
Open Forum Infectious Diseases
Boikos, C. and Joseph, L. and Martineau, C. and Papenburg, J. and Scheifele, D. and Lands, L.C. and De Serres, G. and Chilvers, M. and Quach, C.
DOI: 10.1093/ofid/ofw187
2016

Dornase alfa for cystic fibrosis
Cochrane Database of Systematic Reviews
Yang, C. and Chilvers, M. and Montgomery, M. and Nolan, S.J.
DOI: 10.1002/14651858.CD001127.pub3
2016

Inconclusive Diagnosis of Cystic Fibrosis After Newborn Screening
PEDIATRICS
DOI: 10.1542/peds.2014-2081
06/2015

Casting a look at pediatric plastic bronchitis
International Journal of Pediatric Otorhinolaryngology
Jasinovic, T. and Kozak, F.K. and Moxham, J.P. and Chilvers, M. and Wensley, D. and Seear, M. and Campbell, A. and Ludemann, J.P.
DOI: 10.1016/j.ijporl.2015.07.011
2015

Evaluation of a multidimensional cystic fibrosis transition program: A quality improvement initiative
Journal of Pediatric Nursing
Gravelle, A.M. and Paone, M. and Davidson, A.G.F. and Chilvers, M.A.
DOI: 10.1016/j.pedn.2014.06.011
2015

Surgical masks reduce airborne spread of Pseudomonas aeruginosa in colonized patients with cystic fibrosis
American Journal of Respiratory and Critical Care Medicine
Driessche, K.V. and Hens, N. and Tilley, P. and Quon, B.S. and Chilvers, M.A. and De Groot, R. and Cotton, M.F. and Marais, B.J. and Speert, D.P. and Zlosnik, J.E.A.
DOI: 10.1164/rccm.201503-0481LE
2015

Factors associated with response to treatment of pulmonary exacerbations in cystic fibrosis patients
Journal of Cystic Fibrosis
Waters, V.J. and Stanojevic, S. and Sonneveld, N. and Klingel, M. and Grasemann, H. and Yau, Y.C.W. and Tullis, E. and Wilcox, P. and Freitag, A. and Chilvers, M. and Ratjen, F.A.
DOI: 10.1016/j.jcf.2015.01.007
2015

Burkholderia species infections in patients with cystic fibrosis in British Columbia, Canada: 30 years' experience
Annals of the American Thoracic Society
Zlosnik, J.E.A. and Zhou, G. and Brant, R. and Henry, D.A. and Hird, T.J. and Mahenthiralingam, E. and Chilvers, M.A. and Wilcox, P. and Speert, D.P.
DOI: 10.1513/AnnalsATS.201408-395OC
2015

Randomized controlled trial of biofilm antimicrobial susceptibility testing in cystic fibrosis patients
Journal of Cystic Fibrosis
Yau, Y.C.W. and Ratjen, F. and Tullis, E. and Wilcox, P. and Freitag, A. and Chilvers, M. and Grasemann, H. and Zlosnik, J. and Speert, D. and Corey, M. and Stanojevic, S. and Matukas, L. and Leahy, T.R. and Shih, S. and Waters, V.
DOI: 10.1016/j.jcf.2014.09.013
2015

Use of the SNOT-22 and UPSIT to appropriately select pediatric patients with cystic fibrosis who should be referred to an otolaryngologist: Cross-sectional study
JAMA Otolaryngology - Head and Neck Surgery
Thamboo, A. and Dar Santos, R.C. and Naidoo, L. and Rahmanian, R. and Chilvers, M.A. and Chadha, N.K.
DOI: 10.1001/jamaoto.2014.1650
2014

In need of a patch UP: Recurrent congenital diaphragmatic hernia presenting with a large pleural effusion
Journal of Pediatric Surgery Case Reports
Shariff, F. and McDougall, C.M. and Chilvers, M.A. and Butterworth, S.A.
DOI: 10.1016/j.epsc.2014.09.008
2014

Embolization of a central venous catheter due to pinch-off syndrome
Acta Paediatrica, International Journal of Paediatrics
Gowraiah, V. and Culham, G. and Chilvers, M.A. and Yang, C.L.
DOI: 10.1111/apa.12085
2013

Efficacy and safety of ivacaftor in patients aged 6 to 11 years with cystic fibrosis with a G551D mutation
American Journal of Respiratory and Critical Care Medicine
Davies, J.C. and Wainwright, C.E. and Canny, G.J. and Chilvers, M.A. and Howenstine, M.S. and Munck, A. and Mainz, J.G. and Rodriguez, S. and Li, H. and Yen, K. and Ordo{\~n}ez, C.L. and Ahrens, R.
DOI: 10.1164/rccm.201301-0153OC
2013

Superior herniation of the mediastinum presenting as an anterior neck mass on straining
Pediatric Pulmonology
McDougall, C.M. and Culham, G. and Seear, M.D. and Chilvers, M.A.
DOI: 10.1002/ppul.21618
2012

Inflammasome-mediated IL-1ß production in humans with cystic fibrosis
PLoS ONE
Tang, A. and Sharma, A. and Jen, R. and Hirschfeld, A.F. and Chilvers, M.A. and Lavoie, P.M. and Turvey, S.E.
DOI: 10.1371/journal.pone.0037689
2012

Cystic fibrosis adolescent transition care in Canada: A snapshot of current practice
Paediatrics and Child Health (Canada)
Gravelle, A. and Davidson, G. and Chilvers, M.
DOI: 10.1093/pch/17.10.553
2012

Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses
Journal of Immunology
Blohmke, C.J. and Mayer, M.L. and Tang, A.C. and Hirschfeld, A.F. and Fjell, C.D. and Sze, M.A. and Falsafi, R. and Wang, S. and Hsu, K. and Chilvers, M.A. and Hogg, J.C. and Hancock, R.E.W. and Turvey, S.E.
DOI: 10.4049/jimmunol.1103661
2012

Analysis of ependymal ciliary beat pattern and beat frequency using high speed imaging: Comparison with the photomultiplier and photodiode methods
Cilia
O{'}Callaghan, C. and Sikand, K. and Chilvers, M.A.
DOI: 10.1186/2046-2530-1-8
2012

Effects of a Pseudomonas aeruginosa eradication policy in a cystic fibrosis clinic
Current Opinion in Pulmonary Medicine
Davidson, A.G.F. and Chilvers, M.A. and Lillquist, Y.P.
DOI: 10.1097/MCP.0b013e328358f5a2
2012

Renal function in pediatric cystic fibrosis patients in the first decade of life
Pediatric Nephrology
Prestidge, C. and Chilvers, M.A. and Davidson, A.G.F. and Cho, E. and McMahon, V. and White, C.T.
DOI: 10.1007/s00467-010-1737-1
2011

Case 1: Chronic cough in a Vietnamese adolescent: Should we be sweating?
Paediatrics and Child Health
Luu, K. and Chilvers, M.
DOI: 10.1093/pch/16.8.465a
2011

TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis
Journal of Immunology
Blohmke, C.J. and Park, J. and Hirschfeld, A.F. and Victor, R.E. and Schneiderman, J. and Stefanowicz, D. and Chilvers, M.A. and Durie, P.R. and Corey, M. and Zielenski, J. and Dorfman, R. and Sandford, A.J. and Daley, D. and Turvey, S.E.
DOI: 10.4049/jimmunol.1001513
2010

Long-term comparative trial of two different physiotherapy techniques; postural drainage with percussion and autogenic drainage, in the treatment of cystic fibrosis
Pediatric Pulmonology
Mcilwaine, M. and Wong, L.T. and Chilvers, M. and Davidson, G.F.
DOI: 10.1002/ppul.21247
2010

Diagnostic testing of patients suspected of primary ciliary dyskinesia
American Journal of Respiratory and Critical Care Medicine
Stannard, W.A. and Chilvers, M.A. and Rutman, A.R. and Williams, C.D. and O{'}Callaghan, C.
DOI: 10.1164/rccm.200903-0459OC
2010

Acidification-dependent activation of CD1d-restricted natural killer T cells is intact in cystic fibrosis
Immunology
Rzemieniak, S.E. and Hirschfeld, A.F. and Victor, R.E. and Chilvers, M.A. and Zheng, D. and Van Den Elzen, P. and Turvey, S.E.
DOI: 10.1111/j.1365-2567.2009.03234.x
2010

Pleuropulmonary complications of PVL-positive Staphylococcus aureus infection in children
Acta Paediatrica, International Journal of Paediatrics
Thomas, B. and Pugalenthi, A. and Chilvers, M.
DOI: 10.1111/j.1651-2227.2009.01293.x
2009

Primary ciliary dyskinesia
Paediatrics and Child Health
Chilvers, M.A. and O{'}Callaghan, C.
DOI: 10.1016/j.paed.2007.02.003
2007

Diagnosing primary ciliary dyskinesia
Thorax
O{'}Callaghan, C. and Chilvers, M. and Hogg, C. and Bush, A. and Lucas, J.
DOI: 10.1136/thx.2007.083147
2007

Functional analysis of cilia and ciliated epithelial ultrastructure in healthy children and young adults
Thorax
Chilvers, M.A. and Rutman, A. and O{'}Callaghan, C.
DOI: 10.1136/thorax.58.4.333
2003

Ciliary beat pattern is associated with specific ultrastructural defects in primary ciliary dyskinesia
Journal of Allergy and Clinical Immunology
Chilvers, M.A. and Rutman, A. and O{'}Callaghan, C.
DOI: 10.1016/S0091-6749(03)01799-8
2003

The effects of coronavirus on human nasal ciliated respiratory epithelium
European Respiratory Journal
Chilvers, M.A. and McKean, M. and Rutman, A. and Myint, B.S. and Silverman, M. and O{'}Callaghan, C.
DOI: 10.1183/09031936.01.00093001
2001

Case 1: Assessment: chronic wet cough.
Paediatric respiratory reviews
Chilvers, M.A. and O{'}Callaghan, C.
2000

Local mucociliary defence mechanisms
Paediatric Respiratory Reviews
Chilvers, M.A. and O{'}Callaghan, C.
DOI: 10.1053/prrv.2000.0009
2000

Analysis of ciliary beat pattern and beat frequency using digital high speed imaging: Comparison with the photomultiplier and photodiode methods
Thorax
Chilvers, M.A. and O{'}Callaghan, C.
DOI: 10.1136/thorax.55.4.314
2000

Research

Current Projects
Evalaution of a transitional pathway in CF care
This is a rewtrospective analysis of an quality improvement project to inpmprove health care in CF youth.

Current Projects
Adherence to therapy in CF patients
Co PI:
Self funded.
Evalaution of adherance therapy in CF patients. ldentifying bariers to adherance wuithin BC. This is a joint project with St Pauls.

Current Projects
Establishment of Digitial high speed video in the diagnosis of primary ciliary dyskinesia in BC.
Principal investigator for this trial
Funded: Telethon

Grants

Telethon Award 2009

Research Group Members

Jacob Gravelle, Undergraduate Volunteer:Undergraduate Student
Tony Guo
Jung-Bahadur Kandola, Co-op student
Alam Lakhani, Research Manager
Vanessa McMahon, Nurse Clinician
Nazifaa Vasaya, Research Coordinator
James Zlosnik, Research Associate - Chronic Bacterial Infections in Cystic Fibrosis. Primary Scientist and Manager - Canadian Burkholderia Cepacia Complex research Referral Repository. Project Manager - Centre for Understanding and Preventing Infection in Children. , Research Associate - Chronic Bacterial Infections in Cystic Fibrosis. Primary Scientist and Manager - Canadian Burkholderia Cepacia Complex research Referral Repository. Project Manager - Centre for Understanding and Preventing Infection in Children.