Aging Out of the Blue: Estimating and Calibrating Region-specific Epigenetic Clocks for a Blue Zone via SuperLearner
Nolan Gunter and Andres Cardenas and Michael Kobor and Nicole Gladish and David Rehkopf and William Dow and Luis Rosero-Bixby and Alan Hubbard
DOI:
10.64898/2026.03.02.26346901
03 / 2026
Not all saliva samples are equal: The role of cellular heterogeneity in DNA methylation and epigenetic age analyses with biological and psychosocial factors
Psychoneuroendocrinology
Meingold H. Chan and Mandy Meijer and Sarah M. Merrill and Maggie P.Y. Fu and David Lin and Julia L. MacIsaac and Jenna L. Riis and Douglas A. Granger and Elizabeth A. Thomas and Michael S. Kobor
DOI:
10.1016/j.psyneuen.2025.107688
02 / 2026
Characterizing the regulatory effects of H2A.Z and SWR1-C on gene expression during hydroxyurea exposure in Saccharomyces cerevisiae
PLOS Genetics
Hilary T. Brewis and Peter C. Stirling and Michael S. Kobor
DOI:
10.1371/journal.pgen.1011566
01 / 2025
Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system
Michael Kobor and Karlie Edwards and Sarah Merrill and Chaini Konwar and Marcia Jude and Beryl Zhuang and Mandy Meijer and Erick Navarro-Delgado and Julia MacIsaac and Piushkumar Mandhane and Elinor Simons and Theo Moraes and Meghan Azad and Padmaja Subbarao and Mariona Bustamante and Martine Vrijheid and Stuart Turvey
DOI:
10.21203/rs.3.rs-5141819/v1
11 / 2024
DNA methylation signatures of youth-onset type 2 diabetes and exposure to maternal diabetes
Clinical Epigenetics
Ola E. Salama and Nikho Hizon and Melissa Del Vecchio and Kurt Kolsun and Mario A. Fonseca and David T. S. Lin and Oscar Urtatiz and Julia L. MacIsaac and Michael S. Kobor and Elizabeth A. C. Sellers and Vernon W. Dolinsky and Allison B. Dart and Meaghan J. Jones and Brandy A. Wicklow
DOI:
10.1186/s13148-024-01675-1
05 / 2024
Pediatric Buccal Epithelial Cell Proportions Decrease Reliably With Age: Considerations for PedBE in Pediatric Research
Michael Kobor
DOI:
10.21203/rs.3.rs-4219789/v1
04 / 2024
Rtt107 cooperates with Rad55 or Slx4 to maintain genome stability inSaccharomyces cerevisiae
Joshua A. R. Brown and Michael S. Kobor
DOI:
10.1101/2024.02.05.579050
02 / 2024
Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation
Environmental Pollution
Poojitha Rajasekar and Robert J. Hall and K.C. Binaya and Parth S. Mahapatra and Siva P. Puppala and Dhruma Thakker and Julia L. MacIsaac and David Lin and Michael Kobor and Charlotte E. Bolton and Ian Sayers and Ian P. Hall and Rachel L. Clifford
DOI:
10.1016/j.envpol.2023.122561
11 / 2023
Cross-Tissue Specificity of Pediatric DNA Methylation Associated with Cumulative Family Adversity
Meingold Hiu-ming Chan and Sarah M. Merrill and Fizza Fatima and Julie L. MacIsaac and Jelena Obradovic and W. Thomas Boyce and Michael S. Kobor
DOI:
10.1101/2023.10.04.559423
10 / 2023
The Blood DNA Methylation Clock GrimAge Is a Robust Surrogate for Airway Epithelia Aging.
Biomedicines
Hernandez Cordero AI and Yang CX and Li X and Yang J and Shaipanich T and MacIsaac JL and Lin DTS and Kobor MS and Horvath S and Man SFP and Sin DD and Leung JM
DOI:
10.3390/biomedicines10123094
PubMed:
36551848
12 / 2022
Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis
The Journals of Gerontology: Series A
Megan E Ramaker and David L Corcoran and Abner T Apsley and Michael S Kobor and Virginia B Kraus and William E Kraus and David T S Lin and Melissa C Orenduff and Carl F Pieper and Reem Waziry and Kim M Huffman and Daniel W Belsky
DOI:
10.1093/gerona/glac168
12 / 2022
Sex differences in epigenetic age in Mediterranean high longevity regions.
Frontiers in aging
Engelbrecht HR and Merrill SM and Gladish N and MacIsaac JL and Lin DTS and Ecker S and Chrysohoou CA and Pes GM and Kobor MS and Rehkopf DH
DOI:
10.3389/fragi.2022.1007098
PubMed:
36506464
11 / 2022
A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans.
Genetics
Lu PYT and Kirlin AC and Aristizabal MJ and Brewis HT and Lvesque N and Setiaputra DT and Avvakumov N and Benschop JJ and Groot Koerkamp M and Holstege FCP and Krogan NJ and Yip CK and Kobor MS
DOI:
10.1093/genetics/iyac136
PubMed:
36066422
11 / 2022
Cumulative risk exposure and child cellular aging in a Dutch low-risk community sample.
Psychophysiology
Beijers R and Ten Thije I and Bolhuis E and O'Donnell KJ and Tollenaar MS and Shalev I and Hastings WJ and MacIsaac JL and Lin DTS and Meaney M and Kobor MS and Belsky J and de Weerth C
DOI:
10.1111/psyp.14205
PubMed:
36323627
11 / 2022
Association of Pediatric Buccal Epigenetic Age Acceleration With Adverse Neonatal Brain Growth and Neurodevelopmental Outcomes Among Children Born Very Preterm With a Neonatal Infection.
JAMA network open
Gomaa N and Konwar C and Gladish N and Au-Young SH and Guo T and Sheng M and Merrill SM and Kelly E and Chau V and Branson HM and Ly LG and Duerden EG and Grunau RE and Kobor MS and Miller SP
DOI:
10.1001/jamanetworkopen.2022.39796
PubMed:
36322087
11 / 2022
Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways.
Human molecular genetics
Schaffner SL and Wassouf Z and Lazaro DF and Xylaki M and Gladish N and Lin DTS and MacIsaac J and Ramadori K and Hentrich T and Schulze-Hentrich JM and Outeiro TF and Kobor MS
DOI:
10.1093/hmg/ddac104
PubMed:
35567546
10 / 2022
Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children.
Communications biology
de Lima RMS and Barth B and Mar Arcego D and de Mendona Filho EJ and Patel S and Wang Z and Pokhvisneva I and Parent C and Levitan RD and Kobor MS and Silveira PP
DOI:
10.1038/s42003-022-03992-8
PubMed:
36241774
10 / 2022
Childhood Trauma and Epigenetics: State of the Science and Future
Current Environmental Health Reports
N. Gladish and S. M. Merrill and Michael S. Kobor
DOI:
10.1007/s40572-022-00381-5
10 / 2022
Human complete NFAT1 deficiency causes a triad ofjoint contractures, osteochondromas, and B-cellmalignancy.
Blood
Sharma M and Fu MP and Lu HY and Sharma AA and Modi BP and Michalski C and Lin S and Dalmann J and Salman A and Del Bel KL and Waqas M and Terry J and Setiadi A and Lavoie PM and Turvey SE
DOI:
10.1182/blood.2022015674
PubMed:
35789258
10 / 2022
Attachment insecurity and the biological embedding of reproductive strategies: Investigating the role of cellular aging.
Biological psychology
Bolhuis E and Belsky J and Frankenhuis WE and Shalev I and Hastings WJ and Tollenaar MS and O'Donnell KJ and McGill MG and Pokhvisneva I and Lin DTS and MacIsaac JL and Kobor MS and Beijers R
DOI:
10.1016/j.biopsycho.2022.108446
PubMed:
36272562
10 / 2022
Integrative multi-omics database (iMOMdb) of Asian pregnant women.
Human molecular genetics
Pan H and Tan PF and Lim IY and Huan J and Teh AL and Chen L and Gong M and Tin F and Mir SA and Narasimhan K and Chan JKY and Tan KH and Kobor MS and Meikle PJ and Wenk MR and Chong YS and Karnani N
DOI:
10.1093/hmg/ddac079
PubMed:
35445712
09 / 2022
Peroxisome proliferator-activated receptor gamma gene variants modify human airway and systemic responses to indoor dibutyl phthalate exposure.
Respiratory research
Leung C and Ryu MH and Blling AK and Maestre-Batlle D and Rider CF and Hls A and Urtatiz O and MacIsaac JL and Lau KS and Lin DTS and Kobor MS and Carlsten C
DOI:
10.1186/s12931-022-02174-8
PubMed:
36114491
09 / 2022
To what extent do social support and coping strategies mediate the relation between childhood maltreatment and major depressive disorder: A longitudinal community-based cohort.
Development and psychopathology
Li M and O'Donnell KJ and Caron J and Meaney MJ and Kobor M and D'Arcy C and Su Y and Liu A and Meng X
DOI:
10.1017/s0954579422000918
PubMed:
36102218
09 / 2022
Study protocol for Attachment & Child Health (ATTACHTM) program: promoting vulnerable Children's health at scale.
BMC pediatrics
Anis L and Letourneau N and Ross KM and Hart M and Graham I and Lalonde S and Varro S and Baldwin A and Soulsby A and Majnemer A and Donnelly C and Piotrowski C and Collier C and West Z
DOI:
10.1186/s12887-022-03439-3
PubMed:
35986306
08 / 2022
Fetal sex-specific epigenetic associations with prenatal maternal depressive symptoms.
iScience
Kee MZL and Teh AL and Clappison A and Pokhvisneva I and MacIssac JL and Lin DTS and Ramadori KE and Broekman BFP and Chen H and Daniel ML and Karnani N and Kobor MS and Gluckman PD and Meaney MJ
DOI:
10.1016/j.isci.2022.104860
PubMed:
36046194
08 / 2022
DNA methylation as a mediator of genetic and environmental influences on Parkinson's disease susceptibility: Impacts of alpha-Synuclein, physical activity, and pesticide exposure on the epigenome.
Frontiers in genetics
Schaffner SL and Kobor MS
DOI:
10.3389/fgene.2022.971298
PubMed:
36061205
08 / 2022
The relationship between the epigenetic aging biomarker "grimage" and lung function in both the airway and blood of people living with HIV: An observational cohort study.
EBioMedicine
Hernndez Cordero AI and Yang CX and Yang J and Li X and Horvath S and Shaipanich T and MacIsaac J and Lin D and McEwen L and Kobor MS and Guillemi S and Harris M and Lam W and Lam S and INSIGHT START Pulmonary and Genomic Substudy Groups
DOI:
10.1016/j.ebiom.2022.104206
PubMed:
35944348
08 / 2022
Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease.
American journal of respiratory and critical care medicine
Hernndez Cordero AI and Yang CX and Yang J and Horvath S and Shaipanich T and MacIsaac J and Lin DTS and Kobor MS and Guillemi S and Harris M and Lam W and Lam S and Montaner J and Leung JM
DOI:
10.1164/rccm.202106-1440oc
PubMed:
35426765
07 / 2022
Early IFN secretion determines variable downstream IL-12p70 responses upon TLR4 activation.
Cell reports
Posseme C and Llibre A and Charbit B and Bondet V and Rouilly V and Saint-Andr V and Boussier J and Bergstedt J and Smith N and Townsend L and Sugrue JA and N Cheallaigh C and Milieu Intrieur Consortium
DOI:
10.1016/j.celrep.2022.110989
PubMed:
35767946
06 / 2022
Pruning and thresholding approach for methylation risk scores in multi-ancestry populations
Chen J and Gatev E and Everson T and Conneely KN and Koen N and Epstein MP and Kobor MS and Zar HJ and Stein DJ and Huels A
DOI:
10.1101/2022.06.09.22276204
06 / 2022
Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines.
Clinical epigenetics
Ryan CP and Rege RJ and Lee NR and Carba DB and Kobor MS and MacIsaac JL and Lin DS and Atashzay P and Kuzawa CW
DOI:
10.1186/s13148-022-01296-6
PubMed:
35733189
06 / 2022
Epigenome-wide association study analysis of calorie restriction in humans, CALERIE Trial analysis
Megan E. Ramaker and David L. Corcoran and Abner T. Apsley and Michael S. Kobor and Virginia B. Kraus and William E. Kraus and David T. S. Lin and Melissa C. Orenduff and Carl F. Pieper and Reem Waziry and Kim M. Huffman and Daniel W. Belsky
DOI:
10.1101/2022.06.03.494722
06 / 2022
Birth weight and maternal energy status during pregnancy as predictors of epigenetic age acceleration in young adults from metropolitan Cebu, Philippines.
Epigenetics
Kuzawa CW and Ryan CP and Adair LS and Lee NR and Carba DB and MacIsaac JL and Dever K and Atashzay P and Kobor MS and McDade TW
DOI:
10.1080/15592294.2022.2070105
PubMed:
35574972
05 / 2022
DNA methylation as a potential mediator of the association between indoor air pollution and neurodevelopmental delay in a South African birth cohort
Feil D and Abrishamcar S and Christensen GM and Vanker A and Koen N and Kilanowski A and Hoffman N and Wedderburn CJ and Donald KA and Kobor MS and Zar HJ and Stein DJ and Hls A
DOI:
10.21203/rs.3.rs-1670046/v1
05 / 2022
HIV, pathology and epigenetic age acceleration in different human tissues.
GeroScience
Horvath S and Lin DTS and Kobor MS and Zoller JA and Said JW and Morgello S and Singer E and Yong WH and Jamieson BD and Levine AJ
DOI:
10.1007/s11357-022-00560-0
PubMed:
35411474
04 / 2022
In-utero exposure to indoor air pollution or tobacco smoke and cognitive development in a South African birth cohort study.
The Science of the total environment
Christensen GM and Rowcliffe C and Chen J and Vanker A and Koen N and Jones MJ and Gladish N and Hoffman N and Donald KA and Wedderburn CJ and Kobor MS and Zar HJ and Stein DJ and Hls A
DOI:
10.1016/j.scitotenv.2022.155394
PubMed:
35460774
04 / 2022
Reply to: Crossing the "Birth Border" for Epigenetic Effects.
Biological psychiatry
McGill MG and Pokhvisneva I and Clappison AS and McEwen LM and Beijers R and Tollenaar M and Pham H and Kee MZL and Garg E and de Mendona Filho EJ and Karnani N and Silveira PP and O'Donnell KJ
DOI:
10.1016/j.biopsych.2021.12.008
PubMed:
35249723
03 / 2022
Prenatal exposure to phthalates and peripheral blood and buccal epithelial DNA methylation in infants: An epigenome-wide association study.
Environment international
England-Mason G and Merrill SM and Gladish N and Moore SR and Giesbrecht GF and Letourneau N and MacIsaac JL and MacDonald AM and Kinniburgh DW and Ponsonby AL and Saffery R and APrON Study Team
DOI:
10.1016/j.envint.2022.107183
PubMed:
35325772
03 / 2022
Epigenome-wide association study and epigenetic age acceleration associated with cigarette smoking among Costa Rican adults.
Scientific reports
Cardenas A and Ecker S and Fadadu RP and Huen K and Orozco A and McEwen LM and Engelbrecht HR and Gladish N and Kobor MS and Rosero-Bixby L and Dow WH and Rehkopf DH
DOI:
10.1038/s41598-022-08160-w
PubMed:
35277542
03 / 2022
DNA methylation changes in cord blood and the developmental origins of health and disease - a systematic review and replication study.
BMC genomics
Akhabir L and Stringer R and Desai D and Mandhane PJ and Azad MB and Moraes TJ and Subbarao P and Turvey SE and Par G and Anand SS and NutriGen Alliance
DOI:
10.1186/s12864-022-08451-6
PubMed:
35305575
03 / 2022
Human germline biallelic complete NFAT1 deficiency causes the triad of progressive joint contractures, osteochondromas, and susceptibility to B cell malignancy
Sharma M and Fu MP and Lu HY and Sharma AA and Modi BP and Michalski C and Lin S and Dalmann J and Salman A and Del Bel KL and Waqas M and Terry J and Setiadi A and Lavoie PM and Turvey SE
DOI:
10.1101/2022.01.30.22269378
02 / 2022
HIV, Pathology and epigenetic age acceleration in different human tissues
Horvath S and Lin DT and Kobor MS and Said JW and Morgello S and Singer E and Yong WH and Jamieson BD and Levine AJ
DOI:
10.1101/2022.02.10.480013
02 / 2022
Dichotomy in the Impact of Elevated Maternal Glucose Levels on Neonatal Epigenome.
The Journal of clinical endocrinology and metabolism
Lim IY and Lin X and Teh AL and Wu Y and Chen L and He M and Chan SY and MacIsaac JL and Chan JKY and Tan KH and Chong MFF and Kobor MS and Godfrey KM and Meaney MJ and Lee YS and Eriksson JG and Karnani N
DOI:
10.1210/clinem/dgab710
PubMed:
34633450
02 / 2022
Immune cell type and DNA methylation vary with reproductive status in women: possible pathways for costs of reproduction.
Evolution, medicine, and public health
Ryan CP and Jones MJ and Edgar RD and Lee NR and Kobor MS and McDade TW and Kuzawa CW
DOI:
10.1093/emph/eoac003
PubMed:
35169479
02 / 2022
Newborn differential DNA methylation and subcortical brain volumes as early signs of severe neurodevelopmental delay in a South African Birth Cohort Study.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
Hls A and Wedderburn CJ and Groenewold NA and Gladish N and Jones MJ and Koen N and MacIsaac JL and Lin DTS and Ramadori KE and Epstein MP and Donald KA and Kobor MS and Zar HJ and Stein DJ
DOI:
10.1080/15622975.2021.2016955
PubMed:
34895032
01 / 2022
An invitro chronic damage model impairs inflammatory and regenerative responses in human colonoid monolayers.
Cell reports
Rees WD and Telkar N and Lin DTS and Wong MQ and Poloni C and Fathi A and Kobor M and Zachos NC and Steiner TS
DOI:
10.1016/j.celrep.2021.110283
PubMed:
35045294
01 / 2022
Sex differences in epigenetic age in Mediterranean high longevity regions
Frontiers in aging
Engelbrecht H and Merrill S and Gladish N and MacIsaac J and Lin D and Ecker S and Chrysohoou C and Pes G and Kobor M and Rehkopf D
01 / 2022
What makes a histone variant a variant: Changing H2A to become H2A.Z
PLOS Genetics
Hilary T. Brewis and Alice Y. Wang and Aline Gaub and Justine J. Lau and Peter C. Stirling and Michael S. Kobor
DOI:
10.1371/journal.pgen.1009950
12 / 2021
Association between maternal depression during pregnancy and newborn DNA methylation.
Translational psychiatry
Drzymalla E and Gladish N and Koen N and Epstein MP and Kobor MS and Zar HJ and Stein DJ and Hls A
DOI:
10.1038/s41398-021-01697-w
PubMed:
34750344
11 / 2021
Prenatal Adversity Alters the Epigenetic Profile of the Prefrontal Cortex: Sexually Dimorphic Effects of Prenatal Alcohol Exposure and Food-Related Stress.
Genes
Lussier AA and Bodnar TS and Moksa M and Hirst M and Kobor MS and Weinberg J
DOI:
10.3390/genes12111773
PubMed:
34828381
11 / 2021
Neural correlates of attentional control in social anxiety disorder: the impact of early-life adversity and DNA methylation.
Journal of psychiatry & neuroscience : JPN
Wiegand A and Munk MHJ and Drohm S and Fallgatter AJ and MacIsaac JL and Kobor MS and Nieratschker V and Kreifelts B
DOI:
10.1503/jpn.210064
PubMed:
34916236
11 / 2021
Infant DNA methylation: an early indicator of intergenerational trauma?
Early human development
Moore SR and Merrill SM and Sekhon B and MacIsaac JL and Kobor MS and Giesbrecht GF and Letourneau N and APrON Team
DOI:
10.1016/j.earlhumdev.2021.105519
PubMed:
34890904
11 / 2021
Machine Learning-Based Single Cell and Integrative Analysis Reveals That Baseline mDC Predisposition Correlates With Hepatitis B Vaccine Antibody Response.
Frontiers in immunology
Aevermann BD and Shannon CP and Novotny M and Ben-Othman R and Cai B and Zhang Y and Ye JC and Kobor MS and Gladish N and Lee AH and Blimkie TM and Hancock RE and Llibre A and Duffy D and Scheuermann RH
DOI:
10.3389/fimmu.2021.690470
PubMed:
34777332
10 / 2021
Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIE phase 2.
Experimental gerontology
Dorling JL and Belsky DW and Racette SB and Das SK and Ravussin E and Redman LM and Hchsmann C and Huffman KM and Kraus WE and Kobor MS and MacIsaac JL and Lin DTS and Corcoran DL and Martin CK
DOI:
10.1016/j.exger.2021.111555
PubMed:
34543722
09 / 2021
Autosomal sex-associated co-methylated regions predict biological sex from DNA methylation.
Nucleic acids research
Gatev E and Inkster AM and Negri GL and Konwar C and Lussier AA and Skakkebaek A and Sokolowski MB and Gravholt CH and Dunn EC and Kobor MS and Aristizabal MJ
DOI:
10.1093/nar/gkab682
PubMed:
34403484
09 / 2021
Risk-focused Differences in Molecular Processes Implicated in SARS-CoV-2 Infection: Corollaries in DNA Methylation and Gene Expression
Chaini Konwar and Rebecca Asiimwe and Amy M. Inkster and Sarah M. Merrill and Gian L. Negri and Maria J. Aristizabal and Christopher F. Rider and Julie L. MacIsaac and Christopher Carlsten and Michael S. Kobor
DOI:
10.21203/rs.3.rs-764250/v1
08 / 2021
Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging.
Biological psychiatry
McGill MG and Pokhvisneva I and Clappison AS and McEwen LM and Beijers R and Tollenaar MS and Pham H and Kee MZL and Garg E and de Mendona Filho EJ and Karnani N and Silveira PP and O'Donnell KJ
DOI:
10.1016/j.biopsych.2021.07.025
PubMed:
34756561
08 / 2021
Paternal adverse childhood experiences: Associations with infant DNA methylation.
Developmental psychobiology
Merrill SM and Moore SR and Gladish N and Giesbrecht GF and Dewey D and Konwar C and MacIssac JL and Kobor MS and Letourneau NL
DOI:
10.1002/dev.22174
PubMed:
34333774
08 / 2021
Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging.
Clinical epigenetics
Verschoor CP and Lin DTS and Kobor MS and Mian O and Ma J and Pare G and Ybazeta G
DOI:
10.1186/s13148-021-01150-1
PubMed:
34425884
08 / 2021
Prefrontal cortex VAMP1 gene network moderates the effect of the early environment on cognitive flexibility in children.
Neurobiology of learning and memory
Dalmaz C and Barth B and Pokhvisneva I and Wang Z and Patel S and Quillfeldt JA and Mendona Filho EJ and de Lima RMS and Arcego DM and Sassi RB and Hall GBC and Kobor MS and Meaney MJ and Silveira PP
DOI:
10.1016/j.nlm.2021.107509
PubMed:
34454100
08 / 2021
Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity.
Cell reports
Lam AJ and Lin DTS and Gillies JK and Uday P and Pesenacker AM and Kobor MS and Levings MK
DOI:
10.1016/j.celrep.2021.109494
PubMed:
34348163
08 / 2021
Associations of peripheral blood DNA methylation and estimated monocyte proportion differences during infancy with toddler attachment style.
Attachment & human development
Merrill SM and Gladish N and Fu MP and Moore SR and Konwar C and Giesbrecht GF and MacIssac JL and Kobor MS and Letourneau NL
DOI:
10.1080/14616734.2021.1938872
PubMed:
34196256
07 / 2021
Maternal psychosocial risk factors and child gestational epigenetic age in a South African birth cohort study.
Translational psychiatry
Koen N and Jones MJ and Nhapi RT and Lake MT and Donald KA and Barnett W and Hoffman N and MacIsaac JL and Morin AM and Lin DTS and Kobor MS and Koenen KC and Zar HJ and Stein DJ
DOI:
10.1038/s41398-021-01434-3
PubMed:
34215722
07 / 2021
The Immune Factors Driving DNA Methylation Variation in Human Blood
Jacob Bergstedt and Sadoune Ait Kaci Azzou and Kristin Tsuo and Anthony Jaquaniello and Alejandra Urrutia and Maxime Rotival and David T. S. Lin and Julia L. MacIsaac and Michael S. Kobor and Matthew L. Albert and Darragh Duffy and Etienne Patin and Llus Quintana-Murci
DOI:
10.1101/2021.06.23.449602
06 / 2021
Occurrence of Accelerated Epigenetic Aging and Methylation Disruptions in Human Immunodeficiency Virus Infection Before Antiretroviral Therapy.
The Journal of infectious diseases
Yang CX and Schon E and Obeidat M and Kobor MS and McEwen L and MacIsaac J and Lin D and Novak RM and Hudson F and Klinker H and Dharan N and Horvath S and Bourbeau J and Tan W and Sin DD and Leung JM
DOI:
10.1093/infdis/jiaa599
PubMed:
32959881
05 / 2021
Risky family climates presage increased cellular aging in young adulthood.
Psychoneuroendocrinology
Brody GH and Yu T and Chen E and Kobor M and Beach SRH and Lei MK and Barr A and Lin DT and Miller GE
DOI:
10.1016/j.psyneuen.2021.105256
PubMed:
34058561
05 / 2021
DNA methylation differences associated with social anxiety disorder and early life adversity.
Translational psychiatry
Wiegand A and Kreifelts B and Munk MHJ and Geiselhart N and Ramadori KE and MacIsaac JL and Fallgatter AJ and Kobor MS and Nieratschker V
DOI:
10.1038/s41398-021-01225-w
PubMed:
33542190
02 / 2021
Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factors.
Epigenetics
Huang RC and Melton PE and Burton MA and Beilin LJ and Clarke-Harris R and Cook E and Godfrey KM and Burdge GC and Mori TA and Anderson D and Rauschert S and Craig JM and Kobor MS and Lillycrop KA
DOI:
10.1080/15592294.2021.1876297
PubMed:
33550919
02 / 2021
Optimized CRISPR-mediated gene knock-in reveals FOXP3-independent control of human Treg identity
Avery J. Lam and David T.S. Lin and Jana K. Gillies and Prakruti Uday and Anne M. Pesenacker and Michael S. Kobor and Megan K. Levings
DOI:
10.1101/2021.01.16.426937
01 / 2021
Internalizing symptoms associate with the pace of epigenetic aging in childhood.
Biological psychology
Tollenaar MS and Beijers R and Garg E and Nguyen TTT and Lin DTS and MacIsaac JL and Shalev I and Kobor MS and Meaney MJ and O'Donnell KJ and de Weerth C
DOI:
10.1016/j.biopsycho.2021.108021
PubMed:
33460784
01 / 2021
DNA methylation is associated with airflow obstruction in patients living with HIV.
Thorax
Hernandez Cordero AI and Yang CX and Obeidat M and Yang J and MacIsaac J and McEwen L and Lin D and Kobor M and Novak R and Hudson F and Klinker H and Dharan N and Man SP and Sin DD and INSIGHT START Pulmonary and Genomic Substudy Groups
DOI:
10.1136/thoraxjnl-2020-215866
PubMed:
33443234
12 / 2020
Human T-bet Governs Innate and Innate-like Adaptive IFN- Immunity against Mycobacteria.
Cell
Yang R and Mele F and Worley L and Langlais D and Rosain J and Benhsaien I and Elarabi H and Croft CA and Doisne JM and Zhang P and Weisshaar M and Jarrossay D and Latorre D and Shen Y and Casanova JL
DOI:
10.1016/j.cell.2020.10.046
PubMed:
33296702
12 / 2020
Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder.
Development and psychopathology
Chen LM and Tollenaar MS and Hari Dass SA and Bouvette-Turcot AA and Pokhvisneva I and Gaudreau H and Parent C and Diorio J and McEwen LM and MacIsaac JL and Kobor MS and Beijers R and MAVAN Study Team
DOI:
10.1017/s0954579420001418
PubMed:
33427178
12 / 2020
Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial.
PLoS medicine
Antoun E and Kitaba NT and Titcombe P and Dalrymple KV and Garratt ES and Barton SJ and Murray R and Seed PT and Holbrook JD and Kobor MS and Lin DT and MacIsaac JL and Burdge GC and UPBEAT Consortium
DOI:
10.1371/journal.pmed.1003229
PubMed:
33151971
11 / 2020
Multi-Omic Data Integration Allows Baseline Immune Signatures to Predict Hepatitis B Vaccine Response in a Small Cohort.
Frontiers in immunology
Shannon CP and Blimkie TM and Ben-Othman R and Gladish N and Amenyogbe N and Drissler S and Edgar RD and Chan Q and Krajden M and Foster LJ and Kobor MS and Mohn WW and Brinkman RR and Lee AH
DOI:
10.3389/fimmu.2020.578801
PubMed:
33329547
11 / 2020
Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults.
Frontiers in immunology
Ben-Othman R and Cai B and Liu AC and Varankovich N and He D and Blimkie TM and Lee AH and Gill EE and Novotny M and Aevermann B and Drissler S and Shannon CP and McCann S and Marty K and Sadarangani M
DOI:
10.3389/fimmu.2020.580373
PubMed:
33250895
11 / 2020
TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma.
Clinical epigenetics
Clifford RL and Yang CX and Fishbane N and Patel J and MacIsaac JL and McEwen LM and May ST and Castellanos-Uribe M and Nair P and Obeidat M and Kobor MS and Knox AJ and Hackett TL
DOI:
10.1186/s13148-020-00931-4
PubMed:
33008450
10 / 2020
Maternal exposure to childhood traumatic events, but not multi-domain psychosocial stressors, predict placental corticotrophin releasing hormone across pregnancy.
Social science & medicine (1982)
Steine IM and LeWinn KZ and Lisha N and Tylavsky F and Smith R and Bowman M and Sathyanarayana S and Karr CJ and Smith AK and Kobor M and Bush NR
DOI:
10.1016/j.socscimed.2020.113461
PubMed:
33126094
10 / 2020
Variability in DNA methylation at the serotonin transporter gene promoter: epigenetic mechanism or cell-type artifact?
Molecular Psychiatry
Sarah R. Moore and Michael S. Kobor
DOI:
10.1038/s41380-018-0121-6
09 / 2020
Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution.
Epigenetics
Rabinovitch N and Jones MJ and Gladish N and Faino AV and Strand M and Morin AM and MacIsaac J and Lin DTS and Reynolds PR and Singh A and Gelfand EW and Kobor MS and Carlsten C
DOI:
10.1080/15592294.2020.1790802
PubMed:
32657253
07 / 2020
Distinctions between sex and time in patterns of DNA methylation across puberty.
BMC genomics
Moore SR and Humphreys KL and Colich NL and Davis EG and Lin DTS and MacIsaac JL and Kobor MS and Gotlib IH
DOI:
10.1186/s12864-020-06789-3
PubMed:
32493224
06 / 2020
Multi-Omic Approach to Identify Phenotypic Modifiers Underlying Cerebral Demyelination in X-Linked Adrenoleukodystrophy.
Frontiers in cell and developmental biology
Richmond PA and van der Kloet F and Vaz FM and Lin D and Uzozie A and Graham E and Kobor M and Mostafavi S and Moerland PD and Lange PF and van Kampen AHC and Wasserman WW and van Karnebeek CDM
DOI:
10.3389/fcell.2020.00520
PubMed:
32671069
06 / 2020
CoMeBack: DNA methylation array data analysis for co-methylated regions.
Bioinformatics (Oxford, England)
Gatev E and Gladish N and Mostafavi S and Kobor MS
DOI:
10.1093/bioinformatics/btaa049
PubMed:
31985744
05 / 2020
Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes.
Frontiers in neuroscience
de Lima RMS and Barth B and Arcego DM and de Mendona Filho EJ and Clappison A and Patel S and Wang Z and Pokhvisneva I and Sassi RB and Hall GBC and Kobor MS and O'Donnell KJ and Silveira PP
DOI:
10.3389/fnins.2020.00198
PubMed:
32256307
03 / 2020
Genetic susceptibility to asthma increases the vulnerability to indoor air pollution.
The European respiratory journal
Hls A and Vanker A and Gray D and Koen N and MacIsaac JL and Lin DTS and Ramadori KE and Sly PD and Stein DJ and Kobor MS and Zar HJ
DOI:
10.1183/13993003.01831-2019
PubMed:
31949118
03 / 2020
Epigenetic aging in children from a small-scale farming society in The Congo Basin: Associations with child growth and family conflict
Developmental Psychobiology
Lee T. Gettler and David T. S. Lin and Valchy Miegakanda and Sheina Lew-Levy and Geeta N. Eick and J. Josh Snodgrass and Julia L. MacIsaac and Katia E. Ramadori and Michael S. Kobor and Adam H. Boyette
DOI:
10.1002/dev.21935
03 / 2020
Neonatal Alcohol Exposure in Mice Induces Select Differentiation- and Apoptosis-Related Chromatin Changes Both Independent of and Dependent on Sex.
Frontiers in genetics
Schaffner SL and Lussier AA and Baker JA and Goldowitz D and Hamre KM and Kobor MS
DOI:
10.3389/fgene.2020.00035
PubMed:
32117449
02 / 2020
5-Hydroxymethylcytosine in cord blood and associations of DNA methylation with sex in newborns.
Mutagenesis
Solomon O and Macisaac JL and Tindula G and Kobor MS and Eskenazi B and Holland N
DOI:
10.1093/mutage/gez023
PubMed:
31587037
12 / 2019
Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data
Clinical Epigenetics
Kristina Gervin and Lucas A. Salas and Kelly M. Bakulski and Menno C. van Zelm and Devin C. Koestler and John K. Wiencke and Liesbeth Duijts and Henritte A. Moll and Karl T. Kelsey and Michael S. Kobor and Robert Lyle and Brock C. Christensen and Janine F. Felix and Meaghan J. Jones
DOI:
10.1186/s13148-019-0717-y
12 / 2019
Reversal of epigenetic aging and immunosenescent trends in humans
Aging Cell
Gregory M. Fahy and Robert T. Brooke and James P. Watson and Zinaida Good and Shreyas S. Vasanawala and Holden Maecker and Michael D. Leipold and David T. S. Lin and Michael S. Kobor and Steve Horvath
DOI:
10.1111/acel.13028
12 / 2019
Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation.
Scientific reports
Clifford RL and Patel J and MacIsaac JL and McEwen LM and Johnson SR and Shaw D and Knox AJ and Hackett TL and Kobor MS
DOI:
10.1038/s41598-019-50873-y
PubMed:
31595000
10 / 2019
The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells.
Proceedings of the National Academy of Sciences of the United States of America
McEwen LM and O'Donnell KJ and McGill MG and Edgar RD and Jones MJ and MacIsaac JL and Lin DTS and Ramadori K and Morin A and Gladish N and Garg E and Unternaehrer E and Pokhvisneva I and Kobor MS
DOI:
10.1073/pnas.1820843116
PubMed:
31611402
10 / 2019
Biological embedding of experience: A primer on epigenetics.
Proceedings of the National Academy of Sciences of the United States of America
Aristizabal MJ and Anreiter I and Halldorsdottir T and Odgers CL and McDade TW and Goldenberg A and Mostafavi S and Kobor MS and Binder EB and Sokolowski MB and O'Donnell KJ
DOI:
10.1073/pnas.1820838116
PubMed:
31624126
10 / 2019
DNA methylation of HPA-axis genes and the onset of major depressive disorder in adolescent girls: a prospective analysis.
Translational psychiatry
Humphreys KL and Moore SR and Davis EG and MacIsaac JL and Lin DTS and Kobor MS and Gotlib IH
DOI:
10.1038/s41398-019-0582-7
PubMed:
31582756
10 / 2019
Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast.
The Journal of biological chemistry
Aristizabal MJ and Dever K and Negri GL and Shen M and Hawe N and Benschop JJ and Holstege FCP and Krogan NJ and Sadowski I and Kobor MS
DOI:
10.1074/jbc.ra119.008515
PubMed:
31506296
09 / 2019
MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts.
Nature communications
Chang EY and Tsai S and Aristizabal MJ and Wells JP and Coulombe Y and Busatto FF and Chan YA and Kumar A and Dan Zhu Y and Wang AY and Fournier LA and Hieter P and Kobor MS and Masson JY and Stirling PC
DOI:
10.1038/s41467-019-12271-w
PubMed:
31537797
09 / 2019
Parenting Interacts With Plasticity Genes in Predicting Behavioral Outcomes in Preschoolers.
The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres
Letourneau NL and de Koning APJ and Sekhon B and Ntanda HN and Kobor M and Deane AJ and Morin AM and Dewey D and Campbell TS and Giesbrecht GF and APrON Study Team
DOI:
10.1177/0844562119863612
PubMed:
31403319
08 / 2019
Prenatal exposure to traffic-related air pollution, the gestational epigenetic clock, and risk of early-life allergic sensitization.
The Journal of allergy and clinical immunology
Sbihi H and Jones MJ and MacIsaac JL and Brauer M and Allen RW and Sears MR and Subbarao P and Mandhane PJ and Moraes TJ and Azad MB and Becker AB and Brook JR and Kobor MS and Turvey SE
DOI:
10.1016/j.jaci.2019.07.047
PubMed:
31470034
08 / 2019
Gestational intermittent hypoxia induces endothelial dysfunction, reduces perivascular adiponectin and causes epigenetic changes in adult male offspring.
The Journal of physiology
Badran M and Yassin BA and Lin DTS and Kobor MS and Ayas N and Laher I
DOI:
10.1113/jp277936
PubMed:
31441069
08 / 2019
Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments.
Proceedings of the National Academy of Sciences of the United States of America
Shen Y and Grisdale CJ and Islam SA and Bose P and Lever J and Zhao EY and Grinshtein N and Ma Y and Mungall AJ and Moore RA and Lun X and Senger DL and Robbins SM and Wang AY and Jones SJM
DOI:
10.1073/pnas.1813495116
PubMed:
31471491
08 / 2019
Inflammation-related genes are associated with epigenetic aging in HIV.
Journal of neurovirology
Sundermann EE and Hussain MA and Moore DJ and Horvath S and Lin DTS and Kobor MS and Levine A and HNRP Group
DOI:
10.1007/s13365-019-00777-4
PubMed:
31286441
07 / 2019
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.
Nature communications
Czamara D and Eraslan G and Page CM and Lahti J and Lahti-Pulkkinen M and Hmlinen E and Kajantie E and Laivuori H and Villa PM and Reynolds RM and Nystad W and Hberg SE and Binder EB
DOI:
10.1038/s41467-019-10461-0
PubMed:
31186427
06 / 2019
Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness
Psychoneuroendocrinology
Philipp Toepfer and Kieran J. ODonnell and Sonja Entringer and Elika Garg and Christine M. Heim and David T.S. Lin and Julia L. MacIsaac and Michael S. Kobor and Michael J. Meaney and Nadine Provenal and Elisabeth B. Binder and Pathik D. Wadhwa and Claudia Buss
DOI:
10.1016/j.psyneuen.2019.01.013
05 / 2019
Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome.
Genes, brain, and behavior
Ong ML and Tuan TA and Poh J and Teh AL and Chen L and Pan H and MacIsaac JL and Kobor MS and Chong YS and Kwek K and Saw SM and Godfrey KM and Gluckman PD and Fortier MV and Karnani N and Holbrook JD
DOI:
10.1111/gbb.12576
PubMed:
31020763
05 / 2019
Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS.
The New England journal of medicine
van Kuilenburg ABP and Tarailo-Graovac M and Richmond PA and Drgemller BI and Pouladi MA and Leen R and Brand-Arzamendi K and Dobritzsch D and Dolzhenko E and Eberle MA and van Karnebeek CDM
DOI:
10.1056/nejmoa1806627
PubMed:
30970188
04 / 2019
A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions.
EBioMedicine
Hari Dass SA and McCracken K and Pokhvisneva I and Chen LM and Garg E and Nguyen TTT and Wang Z and Barth B and Yaqubi M and McEwen LM and MacIsaac JL and Diorio J and Kobor MS and Silveira PP
DOI:
10.1016/j.ebiom.2019.03.051
PubMed:
30922963
03 / 2019
A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment.
Journal of the American Academy of Child and Adolescent Psychiatry
Toepfer P and O Donnell KJ and Entringer S and Heim CM and Lin DTS and MacIsaac JL and Kobor MS and Meaney MJ and Provenal N and Binder EB and Wadhwa PD and Buss C
DOI:
10.1016/j.jaac.2019.03.006
PubMed:
30858011
03 / 2019
Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm.
Clinical epigenetics
Wu Y and Lin X and Lim IY and Chen L and Teh AL and MacIsaac JL and Tan KH and Kobor MS and Chong YS and Gluckman PD and Karnani N
DOI:
10.1186/s13148-018-0599-4
PubMed:
30744680
02 / 2019
Budding yeast Rtt107 prevents checkpoint hyperactivation after replicative stress by limiting DNA damage
DNA Repair
Joshua A.R. Brown and Michael S. Kobor
DOI:
10.1016/j.dnarep.2019.01.001
02 / 2019
Genome-wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood.
American journal of physical anthropology
McDade TW and Ryan CP and Jones MJ and Hoke MK and Borja J and Miller GE and Kuzawa CW and Kobor MS
DOI:
10.1002/ajpa.23800
PubMed:
30771258
02 / 2019
Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation.
Epigenetics & chromatin
Islam SA and Goodman SJ and MacIsaac JL and Obradovic J and Barr RG and Boyce WT and Kobor MS
DOI:
10.1186/s13072-018-0245-6
PubMed:
30602389
01 / 2019
Maternal Metabolic Complications in Pregnancy and Offspring Behavior Problems at 2Years of Age.
Maternal and child health journal
Krzeczkowski JE and Lau A and Fitzpatrick J and Tamana S and Smithson L and de Souza R and Kozyrskyj AL and Lefebvre D and Becker AB and Subbarao P and Turvey SE and Pei J and CHILD Study Investigators
DOI:
10.1007/s10995-018-2691-y
PubMed:
30600520
01 / 2019
Social Environment and Epigenetics.
Current topics in behavioral neurosciences
Merrill SM and Gladish N and Kobor MS
DOI:
10.1007/7854_2019_114
PubMed:
31485989
01 / 2019
Prenatal Alcohol Exposure: Profiling Developmental DNA Methylation Patterns in Central and Peripheral Tissues.
Frontiers in genetics
Lussier AA and Bodnar TS and Mingay M and Morin AM and Hirst M and Kobor MS and Weinberg J
DOI:
10.3389/fgene.2018.00610
PubMed:
30568673
12 / 2018
Residential green space and pathways to term birth weight in the Canadian Healthy Infant Longitudinal Development (CHILD) Study.
International journal of health geographics
Cusack L and Sbihi H and Larkin A and Chow A and Brook JR and Moraes T and Mandhane PJ and Becker AB and Azad MB and Subbarao P and Kozyrskyj A and Takaro TK and Sears MR and Turvey SE and CHILD Study Investigators
DOI:
10.1186/s12942-018-0160-x
PubMed:
30514315
12 / 2018
Maternal psychosocial risk factors and offspring gestational epigenetic age acceleration in a South African birth cohort study
Koen N and Jones M and Nhapi RT and Donald KA and Barnett W and Hoffman N and MacIsaac JL and Morin AM and Lin DT and Kobor MS and Koenen KC and Zar HJ and Stein DJ
DOI:
10.1101/503623
12 / 2018
Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation.
Genome biology
Husquin LT and Rotival M and Fagny M and Quach H and Zidane N and McEwen LM and MacIsaac JL and Kobor MS and Aschard H and Patin E and Quintana-Murci L
DOI:
10.1186/s13059-018-1601-3
PubMed:
30563547
12 / 2018
Diagnosing atopic dermatitis in infancy: Questionnaire reports vs criteria-based assessment.
Paediatric and perinatal epidemiology
Dharma C and Lefebvre DL and Tran MM and Lu Z and Lou WYW and Subbarao P and Becker AB and Mandhane PJ and Turvey SE and Moraes TJ and Azad MB and Sears MR and CHILD Study Investigators
DOI:
10.1111/ppe.12525
PubMed:
30461044
11 / 2018
Early-life socioeconomic disadvantage, not current, predicts accelerated epigenetic aging of monocytes
Psychoneuroendocrinology
Makeda K. Austin and Edith Chen and Kharah M. Ross and Lisa M. McEwen and Julia L. Maclsaac and Michael S. Kobor and Gregory E. Miller
DOI:
10.1016/j.psyneuen.2018.07.007
11 / 2018
Early post-conception maternal cortisol, children's HPAA activity and DNA methylation profiles.
Journal of developmental origins of health and disease
Barha CK and Salvante KG and Jones MJ and Farr P and Blais J and Kobor MS and Zeng L and Emberly E and Nepomnaschy PA
DOI:
10.1017/s2040174418000880
PubMed:
30428949
11 / 2018
The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation.
Epigenomics
Bush NR and Edgar RD and Park M and MacIsaac JL and McEwen LM and Adler NE and Essex MJ and Kobor MS and Boyce WT
DOI:
10.2217/epi-2018-0042
PubMed:
30351206
10 / 2018
Variably methylated regions in the newborn epigenome: environmental, genetic and combined influences
Czamara D and Eraslan G and Lahti J and Page CM and Lahti-Pulkkinen M and Hmlinen E and Kajantie E and Laivuori H and Villa PM and Reynolds RM and Nystad W and Haberg SE and Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
DOI:
10.1101/436113
10 / 2018
Cell type-specific DNA methylation in neonatal cord tissue and cord blood: a 850K-reference panel and comparison of cell types.
Epigenetics
Lin X and Tan JYL and Teh AL and Lim IY and Liew SJ and MacIsaac JL and Chong YS and Gluckman PD and Kobor MS and Cheong CY and Karnani N
DOI:
10.1080/15592294.2018.1522929
PubMed:
30232931
10 / 2018
Exposure to childhood abuse is associated with human sperm DNA methylation.
Translational psychiatry
Roberts AL and Gladish N and Gatev E and Jones MJ and Chen Y and MacIsaac JL and Tworoger SS and Austin SB and Tanrikut C and Chavarro JE and Baccarelli AA and Kobor MS
DOI:
10.1038/s41398-018-0252-1
PubMed:
30279435
10 / 2018
Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array.
Clinical epigenetics
McEwen LM and Jones MJ and Lin DTS and Edgar RD and Husquin LT and MacIsaac JL and Ramadori KE and Morin AM and Rider CF and Carlsten C and Quintana-Murci L and Horvath S and Kobor MS
DOI:
10.1186/s13148-018-0556-2
PubMed:
30326963
10 / 2018
Children's biobehavioral reactivity to challenge predicts DNA methylation in adolescence and emerging adulthood.
Developmental science
Goodman SJ and Roubinov DS and Bush NR and Park M and Farr P and Emberly E and Hertzman C and Essex MJ and Kobor MS and Boyce WT
DOI:
10.1111/desc.12739
PubMed:
30176105
09 / 2018
The early care environment and DNA methylome variation in childhood.
Development and psychopathology
Garg E and Chen L and Nguyen TTT and Pokhvisneva I and Chen LM and Unternaehrer E and MacIsaac JL and McEwen LM and Mah SM and Gaudreau H and Levitan R and Moss E and Sokolowski MB and Mavan Study Team
DOI:
10.1017/s0954579418000627
PubMed:
30068421
08 / 2018
Comparison of DNA methylation measured by Illumina 450K and EPIC BeadChips in blood of newborns and 14-year-old children.
Epigenetics
Solomon O and MacIsaac J and Quach H and Tindula G and Kobor MS and Huen K and Meaney MJ and Eskenazi B and Barcellos LF and Holland N
DOI:
10.1080/15592294.2018.1497386
PubMed:
30044683
08 / 2018
Differences in DNA methylation of white blood cell types at birth and in adulthood reflect postnatal immune maturation and influence accuracy of cell type prediction
Jones M and Dinh L and Razzaghian HR and de Goede O and MacIsaac JL and Morin AM and Gervin K and Ng R and Duijts L and van Zelm MC and Moll HA and Lyle R and Robinson WP and Koestler DC and Kobor MS
DOI:
10.1101/399279
08 / 2018
An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior.
Development and psychopathology
Conradt E and Adkins DE and Crowell SE and Monk C and Kobor MS
DOI:
10.1017/S0954579418000688
PubMed:
30068429
08 / 2018
PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores.
BMC bioinformatics
Chen LM and Yao N and Garg E and Zhu Y and Nguyen TTT and Pokhvisneva I and Hari Dass SA and Unternaehrer E and Gaudreau H and Forest M and McEwen LM and MacIsaac JL and Kobor MS and O'Donnell KJ
DOI:
10.1186/s12859-018-2289-9
PubMed:
30089455
08 / 2018
Reproduction predicts shorter telomeres and epigenetic age acceleration among young adult women
Scientific Reports
Calen P. Ryan and M. Geoffrey Hayes and Nanette R. Lee and Thomas W. McDade and Meaghan J. Jones and Michael S. Kobor and Christopher W. Kuzawa and Dan T. A. Eisenberg
DOI:
10.1038/s41598-018-29486-4
07 / 2018
Exploring the Genetic Basis of Human Population Differences in DNA Methylation and their Causal Impact on Immune Gene Regulation
Lucas T. Husquin and Maxime Rotival and Maud Fagny and Hlne Quach and Nora Zidane and Lisa M. McEwen and Julia L. MacIsaac and Michael S Kobor and Hugues Aschard and Etienne Patin and Lluis Quintana-Murci
DOI:
10.1101/371872
07 / 2018
Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents.
AIDS (London, England)
Horvath S and Stein DJ and Phillips N and Heany SJ and Kobor MS and Lin DTS and Myer L and Zar HJ and Levine AJ and Hoare J
DOI:
10.1097/qad.0000000000001854
PubMed:
29746298
07 / 2018
Human milk oligosaccharide profiles and food sensitization among infants in the CHILD Study.
Allergy
Miliku K and Robertson B and Sharma AK and Subbarao P and Becker AB and Mandhane PJ and Turvey SE and Lefebvre DL and Sears MR and CHILD Study Investigators and Bode L and Azad MB
DOI:
10.1111/all.13476
PubMed:
29775217
05 / 2018
Cysteinyl Leukotriene Receptor 1 and Health Effects of Particulate Exposure in Asthma.
Annals of the American Thoracic Society
Rabinovitch N and Jones MJ and Faino A and Strand M and Morin AM and MacIsaac J and Reynolds PR and Singh A and Kobor MS and Gelfand EW and Carlsten C
DOI:
10.1513/annalsats.201706-469mg
PubMed:
29676619
04 / 2018
A novel, biologically-informed polygenic score reveals role of mesocorticolimbic insulin receptor gene network on impulsivity and addiction
McCracken K and Hari Dass SA and Pokhvisneva I and Chen LM and Garg E and Nguyen TT and Yaqubi M and McEwen LM and MacIsaac JL and Diorio J and Kobor MS and O'Donnell KJ and Meaney MJ and Silveira P
DOI:
10.1101/289983
03 / 2018
DNA methylation signatures in peripheral blood mononuclear cells from a lifestyle intervention for women at midlife: a pilot randomized controlled trial.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
McEwen LM and Gatev EG and Jones MJ and MacIsaac JL and McAllister MM and Goulding RE and Madden KM and Dawes MG and Kobor MS and Ashe MC
DOI:
10.1139/apnm-2017-0436
PubMed:
29049890
03 / 2018
Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study.
The Journal of allergy and clinical immunology
Tran MM and Lefebvre DL and Dharma C and Dai D and Lou WYW and Subbarao P and Becker AB and Mandhane PJ and Turvey SE and Sears MR and Canadian Healthy Infant Longitudinal Development Study investigators
DOI:
10.1016/j.jaci.2017.08.024
PubMed:
29153857
02 / 2018
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up.
Translational psychiatry
O'Donnell KJ and Chen L and MacIsaac JL and McEwen LM and Nguyen T and Beckmann K and Zhu Y and Chen LM and Brooks-Gunn J and Goldman D and Grigorenko EL and Leckman JF and Diorio J and Meaney MJ
DOI:
10.1038/s41398-017-0063-9
PubMed:
29317599
01 / 2018
Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Dharma C and Lefebvre DL and Tran MM and Lou WYW and Subbarao P and Becker AB and Mandhane PJ and Turvey SE and Sears MR and CHILD Study investigators
DOI:
10.1111/cea.13063
PubMed:
29143385
01 / 2018
Healthy Foundations Study: a randomised controlled trial to evaluate biological embedding of early-life experiences.
BMJ open
Gonzalez A and Catherine N and Boyle M and Jack SM and Atkinson L and Kobor M and Sheehan D and Tonmyr L and Waddell C and MacMillan HL and Healthy Foundations Study Team
DOI:
10.1136/bmjopen-2017-018915
PubMed:
29374668
01 / 2018
DNA methylation as a predictor of fetal alcohol spectrum disorder.
Clinical epigenetics
Lussier AA and Morin AM and MacIsaac JL and Salmon J and Weinberg J and Reynolds JN and Pavlidis P and Chudley AE and Kobor MS
DOI:
10.1186/s13148-018-0439-6
PubMed:
29344313
Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD.
Clinical epigenetics
Clifford RL and Fishbane N and Patel J and MacIsaac JL and McEwen LM and Fisher AJ and Brandsma CA and Nair P and Kobor MS and Hackett TL and Knox AJ
DOI:
10.1186/s13148-018-0464-5
PubMed:
29527240
Epigenetic analysis of human postmortem brain tissue.
Handbook of clinical neurology
Islam SA and Lussier AA and Kobor MS
DOI:
10.1016/b978-0-444-63639-3.00017-7
PubMed:
29496144
Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time.
Epigenetics
Forest M and O'Donnell KJ and Voisin G and Gaudreau H and MacIsaac JL and McEwen LM and Silveira PP and Steiner M and Kobor MS and Meaney MJ and Greenwood CMT
DOI:
10.1080/15592294.2017.1411443
PubMed:
29381404
Choice of surrogate tissue influences neonatal EWAS findings.
BMC medicine
Lin X and Teh AL and Chen L and Lim IY and Tan PF and MacIsaac JL and Morin AM and Yap F and Tan KH and Saw SM and Lee YS and Holbrook JD and Godfrey KM and Meaney MJ and Kobor MS and Chong YS and Karnani N
DOI:
10.1186/s12916-017-0970-x
PubMed:
29202839
12 / 2017
Epigenetic correlates of neonatal contact in humans.
Development and psychopathology
Moore SR and McEwen LM and Quirt J and Morin A and Mah SM and Barr RG and Boyce WT and Kobor MS
DOI:
10.1017/s0954579417001213
PubMed:
29162165
12 / 2017
PRS-on-Spark: a novel, efficient and flexible approach for generating polygenic risk scores
Chen LM and Yao N and Garg E and Zhu Y and Nguyen TTT and Pokhvisneva I and Hari Dass SA and Forest M and McEwen LM and MacIsaac JL and Kobor MS and Greenwood CMT and Silveira PP and O'Donnell KJ
DOI:
10.1101/209833
11 / 2017
Modes of Infant Feeding and the Risk of Childhood Asthma: A Prospective Birth Cohort Study.
The Journal of pediatrics
Klopp A and Vehling L and Becker AB and Subbarao P and Mandhane PJ and Turvey SE and Lefebvre DL and Sears MR and CHILD Study Investigators and Azad MB
DOI:
10.1016/j.jpeds.2017.07.012
PubMed:
29144244
11 / 2017
Birth weight and postnatal microbial exposures predict the distribution of peripheral blood leukocyte subsets in young adults in the Philippines.
Journal of developmental origins of health and disease
DOI:
10.1017/s2040174417000794
PubMed:
29017617
10 / 2017
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.
The Journal of cell biology
DOI:
10.1083/jcb.201703168
PubMed:
29042409
10 / 2017
DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly.
Experimental gerontology
DOI:
10.1016/j.exger.2017.10.010
PubMed:
29032243
10 / 2017
Principles and Challenges of Applying Epigenetic Epidemiology to Psychology.
Annual review of psychology
DOI:
10.1146/annurev-psych-122414-033653
PubMed:
29035689
10 / 2017
Exploring genetic influences underlying acute aerobic exercise effects on motor learning.
Scientific reports
DOI:
10.1038/s41598-017-12422-3
PubMed:
28935933
09 / 2017
Accelerated DNA methylation age in adolescent girls: associations with elevated diurnal cortisol and reduced hippocampal volume.
Translational psychiatry
DOI:
10.1038/tp.2017.188
PubMed:
28850111
08 / 2017
Timing of food introduction and development of food sensitization in a prospective birth cohort.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
DOI:
10.1111/pai.12739
PubMed:
28557044
08 / 2017
Worldwide patterns of human epigenetic variation
Nature Ecology & Evolution
Oana Carja and Julia L. MacIsaac and Sarah M. Mah and Brenna M. Henn and Michael S. Kobor and Marcus W. Feldman and Hunter B. Fraser
DOI:
10.1038/s41559-017-0299-z
08 / 2017
BECon: a tool for interpreting DNA methylation findings from blood in the context of brain.
Translational psychiatry
DOI:
10.1038/tp.2017.171
PubMed:
28763057
08 / 2017
DNA methylation signatures of chronic alcohol dependence in purified CD3+ T-cells of patients undergoing alcohol treatment
Scientific Reports
Christof Brckmann and Sumaiya A. Islam and Julia L. MacIsaac and Alexander M. Morin and Kathrin N. Karle and Adriana Di Santo and Richard Wst and Immanuel Lang and Anil Batra and Michael S. Kobor and Vanessa Nieratschker
DOI:
10.1038/s41598-017-06847-z
07 / 2017
Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood.
Proceedings of the National Academy of Sciences of the United States of America
DOI:
10.1073/pnas.1620661114
PubMed:
28673994
07 / 2017
Trends in DNA Methylation with Age Replicate Across Diverse Human Populations.
Genetics
DOI:
10.1534/genetics.116.195594
PubMed:
28533441
07 / 2017
Blood and nasal epigenetics correlate with allergic rhinitis symptom development in the environmental exposure unit.
Allergy
DOI:
10.1111/all.13263
PubMed:
28755526
07 / 2017
The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study.
BMC genetics
DOI:
10.1186/s12863-017-0525-3
PubMed:
28637423
06 / 2017
The Intersection Of Aging Biology and The Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.
Budinger GS and Kohanski RA and Gan W and Kobor MS and Amaral LA and Armanios M and Kelsey KT and Pardo A and Tuder R and Macian F and Chandel N and Vaughan D and Rojas M and Mora AL and Kovacs E and Duncan SR and Finkel T and Choi A and Eickelberg O and Chen D and dummy-AUTHOR_name and Thannickal VJ
DOI:
10.1093/gerona/glx090
PubMed:
28498894
05 / 2017
Exposure to household furry pets influences the gut microbiota of infant at 3-4months following various birth scenarios.
Tun HM and Konya T and Takaro TK and Brook JR and Chari R and Field CJ and Guttman DS and Becker AB and Mandhane PJ and Turvey SE and Subbarao P and Sears MR and Scott JA and Kozyrskyj AL and CHILD Study Investigators
DOI:
10.1186/s40168-017-0254-x
PubMed:
28381231
04 / 2017
Epigenetics studies of fetal alcohol spectrum disorder: where are we now?
Lussier AA and Weinberg J and Kobor MS
DOI:
10.2217/epi-2016-0163
PubMed:
28234026
03 / 2017
Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome.
Lin X and Lim IY and Wu Y and Teh AL and Chen L and Aris IM and Soh SE and Tint MT and MacIsaac JL and Morin AM and Yap F and Tan KH and Saw SM and Kobor MS and Meaney MJ and Godfrey KM and Chong YS and Holbrook JD and Lee YS and Gluckman PD
DOI:
10.1186/s12916-017-0800-1
PubMed:
28264723
03 / 2017
Longitudinal study of surrogate aging measures during human immunodeficiency virus seroconversion.
Leung JM and Fishbane N and Jones M and Morin A and Xu S and Liu JC and MacIsaac J and Milloy MJ and Hayashi K and Montaner J and Horvath S and Kobor M and Sin DD and Harrigan PR and Man SF
DOI:
10.18632/aging.101184
PubMed:
28237978
02 / 2017
Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation.
Clifford RL and Jones MJ and MacIsaac JL and McEwen LM and Goodman SJ and Mostafavi S and Kobor MS and Carlsten C
DOI:
10.1016/j.jaci.2016.03.046
PubMed:
27321436
01 / 2017
An empirically driven data reduction method on the human 450K methylation array to remove tissue specific non-variable CpGs.
Edgar RD and Jones MJ and Robinson WP and Kobor MS
DOI:
10.1186/s13148-017-0320-z
PubMed:
28184257
Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region.
McEwen LM and Morin AM and Edgar RD and MacIsaac JL and Jones MJ and Dow WH and Rosero-Bixby L and Kobor MS and Rehkopf DH
DOI:
10.1186/s13072-017-0128-2
PubMed:
28465725
Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth.
Girchenko P and Lahti J and Czamara D and Knight AK and Jones MJ and Suarez A and Hmlinen E and Kajantie E and Laivuori H and Villa PM and Reynolds RM and Kobor MS and Smith AK and Binder EB and Rikknen K
DOI:
10.1186/s13148-017-0349-z
PubMed:
28503212
Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy.
Frontiers in Pediatrics
DOI:
10.3389/fped.2017.00200
PubMed:
29018787
Fecal Short-Chain Fatty Acid Variations by Breastfeeding Status in Infants at 4Months: Differences in Relative versus Absolute Concentrations.
Bridgman SL and Azad MB and Field CJ and Haqq AM and Becker AB and Mandhane PJ and Subbarao P and Turvey SE and Sears MR and Scott JA and Wishart DS and Kozyrskyj AL and CHILD Study Investigators
DOI:
10.3389/fnut.2017.00011
PubMed:
28443284
Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs.
Clinical epigenetics
DOI:
10.1186/s13148-017-0370-2
PubMed:
28770015
Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome.
Steunou AL and Cramet M and Rossetto D and Aristizabal MJ and Lacoste N and Drouin S and Ct V and Paquet E and Utley RT and Krogan N and Robert F and Kobor MS and Ct J
DOI:
10.1128/mcb.00112-16
PubMed:
27550811
11 / 2016
Genome-wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up.
Gref A and Kebede Merid S and Gruzieva O and Ballereau S and Becker A and Bellander T and Bergstrm A and Boss Y and Bottai M and Chan-Yeung M and Fuertes E and Ierodiakonou D and Jiang R and Joly S and Jones M and Kobor MS and Korek M and Kozyrskyj AL and Kumar A and Lemonnier N
PubMed:
27901618
11 / 2016
An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.
Horvath S and Gurven M and Levine ME and Trumble BC and Kaplan H and Allayee H and Ritz BR and Chen B and Lu AT and Rickabaugh TM and Jamieson BD and Sun D and Li S and Chen W and Quintana-Murci L and Fagny M and Kobor MS and Tsao PS and Reiner AP and Edlefsen KL
DOI:
10.1186/s13059-016-1030-0
PubMed:
27511193
08 / 2016
Epigenetics: A New Model for Intracellular Parasite-Host Cell Regulation.
Robert McMaster W and Morrison CJ and Kobor MS
DOI:
10.1016/j.pt.2016.04.002
PubMed:
27142564
04 / 2016
DNA Methylation Profiling in Human Huntington's Disease Brain.
De Souza RA and Islam SA and McEwen LM and Mathelier A and Hill A and Mah SM and Wasserman WW and Kobor MS and Leavitt BR
PubMed:
26953320
03 / 2016
A single flexible RNAPII-CTD integrates many different transcriptional programs.
Aristizabal MJ and Kobor MS
DOI:
10.1080/21541264.2016.1163451
PubMed:
26985717
03 / 2016
Low birth weight associates with hippocampal gene expression.
Buschdorf JP and Ong ML and Ong SX and MacIsaac JL and Chng K and Kobor MS and Meaney MJ and Holbrook JD
DOI:
10.1016/j.neuroscience.2016.01.013
PubMed:
26791528
03 / 2016
Differential DNA methylation in peripheral blood mononuclear cells in adolescents exposed to significant early but not later childhood adversity.
Esposito EA and Jones MJ and Doom JR and MacIsaac JL and Gunnar MR and Kobor MS
PubMed:
26847422
02 / 2016
Infant gut immunity: a preliminary study of IgA associations with breastfeeding.
Bridgman SL and Konya T and Azad MB and Sears MR and Becker AB and Turvey SE and Mandhane PJ and Subbarao P and CHILD Study Investigators and Scott JA and Field CJ and Kozyrskyj AL
DOI:
10.1017/S2040174415007862
PubMed:
26690933
02 / 2016
funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types.
Oros Klein K and Grinek S and Bernatsky S and Bouchard L and Ciampi A and Colmegna I and Fortin JP and Gao L and Hivert MF and Hudson M and Kobor MS and Labbe A and MacIsaac JL and Meaney MJ and Morin AM and O'Donnell KJ and Pastinen T and Van Ijzendoorn MH and Voisin G and Greenwood CM
DOI:
10.1093/bioinformatics/btv615
PubMed:
26500152
02 / 2016
Comparison of Methyl-capture Sequencing vs. Infinium 450K methylation array for methylome analysis in clinical samples.
Teh AL and Pan H and Lin X and Lim YI and Patro CP and Cheong CY and Gong M and MacIsaac JL and Kwoh CK and Meaney MJ and Kobor MS and Chong YS and Gluckman PD and Holbrook JD and Karnani N
DOI:
10.1080/15592294.2015.1132136
PubMed:
26786415
01 / 2016
Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats.
Beery AK and McEwen LM and MacIsaac JL and Francis DD and Kobor MS
DOI:
10.1016/j.yhbeh.2015.05.022
PubMed:
26122287
01 / 2016
Rtt107 BRCT domains act as a targeting module in the DNA damage response.
Leung GP and Brown JA and Glover JN and Kobor MS
DOI:
10.1016/j.dnarep.2015.10.007
PubMed:
26641499
01 / 2016
Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL).
Koestler DC and Jones MJ and Usset J and Christensen BC and Butler RA and Kobor MS and Wiencke JK and Kelsey KT
DOI:
10.1186/s12859-016-0943-7
PubMed:
26956433
AllerGens 8th research conference.
Arrieta M and Arevalos A and Stiemsma L and Chico ME and Sandoval C and Jin M and Walter J and Cooper P and Finlay B and Bernatchez E and Gold MJ and Langlois A and Blais-Lecours P and Duchaine C and Marsolais D and McNagny KM and Blanchet M and Brubacher J and Chhetri B and Sabaliauskas K
DNA methylation signature of human fetal alcohol spectrum disorder.
Portales-Casamar E and Lussier AA and Jones MJ and MacIsaac JL and Edgar RD and Mah SM and Barhdadi A and Provost S and Lemieux-Perreault LP and Cynader MS and Chudley AE and Dub MP and Reynolds JN and Pavlidis P and Kobor MS
DOI:
10.1186/s13072-016-0074-4
PubMed:
27358653
DNA methylation and healthy human aging.
Jones MJ and Goodman SJ and Kobor MS
DOI:
10.1111/acel.12349
PubMed:
25913071
12 / 2015
Bacterial infection remodels the DNA methylation landscape of human dendritic cells.
Pacis A and Tailleux L and Morin AM and Lambourne J and MacIsaac JL and Yotova V and Dumaine A and Danckaert A and Luca F and Grenier JC and Hansen KD and Gicquel B and Yu M and Pai A and He C and Tung J and Pastinen T and Kobor MS and Pique-Regi R and Gilad Y
DOI:
10.1101/gr.192005.115
PubMed:
26392366
12 / 2015
Maternal early life adversities and the offspring's epigenome: A M.A.V.A.N. project.
Unternaehrer E and O'Donnell K and Bouvette-Turcot AA and Gaudreau H and Cost K and Fleming A and Steiner M and MacIsaac J and Mah S and McEwen L and Kobor M and Chen L and Pan H and Hui WY and Holbrook J and Meaney M and Study Team MAVAN
DOI:
10.1016/j.psyneuen.2015.07.477
PubMed:
26383363
11 / 2015
The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma.
Subbarao P and Anand SS and Becker AB and Befus AD and Brauer M and Brook JR and Denburg JA and HayGlass KT and Kobor MS and Kollmann TR and Kozyrskyj AL and Lou WY and Mandhane PJ and Miller GE and Moraes TJ and Pare PD and Scott JA and Takaro TK and Turvey SE and Duncan JM
DOI:
10.1136/thoraxjnl-2015-207246
PubMed:
26069286
10 / 2015
The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition.
Aristizabal MJ and Negri GL and Kobor MS
DOI:
10.1371/journal.pgen.1005608
PubMed:
26496706
10 / 2015
Prenatal alcohol exposure alters gene expression in the rat brain: Experimental design and bioinformatic analysis of microarray data.
Lussier AA and Stepien KA and Weinberg J and Kobor MS
DOI:
10.1016/j.dib.2015.05.007
PubMed:
26217797
09 / 2015
Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.
Azad MB and Konya T and Persaud RR and Guttman DS and Chari RS and Field CJ and Sears MR and Mandhane PJ and Turvey SE and Subbarao P and Becker AB and Scott JA and Kozyrskyj AL and CHILD Study Investigators
PubMed:
26412384
09 / 2015
Adjusting for Cell Type Composition in DNA Methylation Data Using a Regression-Based Approach.
Jones MJ and Islam SA and Edgar RD and Kobor MS
DOI:
10.1007/7651_2015_262
PubMed:
26126446
07 / 2015
A pooling-based approach to mapping genetic variants associated with DNA methylation.
Kaplow IM and MacIsaac JL and Mah SM and McEwen LM and Kobor MS and Fraser HB
DOI:
10.1101/gr.183749.114
PubMed:
25910490
06 / 2015
Landscape of DNA methylation on the X chromosome reflects CpG density, functional chromatin state and X-chromosome inactivation.
Cotton AM and Price EM and Jones MJ and Balaton BP and Kobor MS and Brown CJ
DOI:
10.1093/hmg/ddu564
PubMed:
25381334
03 / 2015
Infant gut microbiota and food sensitization: associations in the first year of life.
Azad MB and Konya T and Guttman DS and Field CJ and Sears MR and HayGlass KT and Mandhane PJ and Turvey SE and Subbarao P and Becker AB and Scott JA and Kozyrskyj AL and CHILD Study Investigators
DOI:
10.1111/cea.12487
PubMed:
25599982
03 / 2015
Prenatal alcohol exposure alters steady-state and activated gene expression in the adult rat brain.
Lussier AA and Stepien KA and Neumann SM and Pavlidis P and Kobor MS and Weinberg J
DOI:
10.1111/acer.12622
PubMed:
25684047
02 / 2015
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes.
Chen L and Pan H and Tuan TA and Teh AL and MacIsaac JL and Mah SM and McEwen LM and Li Y and Chen H and Broekman BF and Buschdorf JP and Chong YS and Kwek K and Saw SM and Gluckman PD and Fortier MV and Rifkin-Graboi A and Kobor MS and Qiu A and Meaney MJ
DOI:
10.1017/S0954579414001357
PubMed:
25640836
02 / 2015
Development and the epigenome: the 'synapse' of gene-environment interplay.
Boyce WT and Kobor MS
DOI:
10.1111/desc.12282
PubMed:
25546559
01 / 2015
The Canadian healthy infant longitudinal development birth cohort study: biological samples and biobanking.
Moraes TJ and Lefebvre DL and Chooniedass R and Becker AB and Brook JR and Denburg J and HayGlass KT and Hegele RG and Kollmann TR and Macri J and Mandhane PJ and Scott JA and Subbarao P and Takaro TK and Turvey SE and Duncan JD and Sears MR and Befus AD and CHILD Study Investigators
DOI:
10.1111/ppe.12161
PubMed:
25405552
01 / 2015
HIF3A association with adiposity: the story begins before birth.
Pan H and Lin X and Wu Y and Chen L and Teh AL and Soh SE and Lee YS and Tint MT and MacIsaac JL and Morin AM and Tan KH and Yap F and Saw SM and Kobor MS and Meaney MJ and Godfrey KM and Chong YS and Gluckman PD and Karnani N and Holbrook JD
DOI:
10.2217/epi.15.45
PubMed:
26011824
The epigenomic landscape of African rainforest hunter-gatherers and farmers.
Fagny M and Patin E and MacIsaac JL and Rotival M and Flutre T and Jones MJ and Siddle KJ and Quach H and Harmant C and McEwen LM and Froment A and Heyer E and Gessain A and Betsem E and Mouguiama-Daouda P and Hombert JM and Perry GH and Barreiro LB and Kobor MS and Quintana-Murci L
DOI:
10.1038/ncomms10047
PubMed:
26616214
Concordant and discordant DNA methylation signatures of aging in human blood and brain.
Farr P and Jones MJ and Meaney MJ and Emberly E and Turecki G and Kobor MS
DOI:
10.1186/s13072-015-0011-y
PubMed:
25977707
The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures.
Takaro TK and Scott JA and Allen RW and Anand SS and Becker AB and Befus AD and Brauer M and Duncan J and Lefebvre DL and Lou W and Mandhane PJ and McLean KE and Miller G and Sbihi H and Shu H and Subbarao P and Turvey SE and Wheeler AJ and Zeng L and Sears MR
DOI:
10.1038/jes.2015.7
PubMed:
25805254
Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates.
Gurnot C and Martin-Subero I and Mah SM and Weikum W and Goodman SJ and Brain U and Werker JF and Kobor MS and Esteller M and Oberlander TF and Hensch TK
DOI:
10.1080/15592294.2015.1026031
PubMed:
25891251
Discordance of DNA methylation variance between two accessible human tissues.
Jiang R and Jones MJ and Chen E and Neumann SM and Fraser HB and Miller GE and Kobor MS
DOI:
10.1038/srep08257
PubMed:
25660083
Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells.
de Goede OM and Razzaghian HR and Price EM and Jones MJ and Kobor MS and Robinson WP and Lavoie PM
DOI:
10.1186/s13148-015-0129-6
PubMed:
26366232
Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers.
Miller GE and Murphy ML and Cashman R and Ma R and Ma J and Arevalo JM and Kobor MS and Cole SW
DOI:
10.1016/j.bbi.2014.05.016
PubMed:
25242587
10 / 2014
Leishmania donovani infection causes distinct epigenetic DNA methylation changes in host macrophages.
Marr AK and MacIsaac JL and Jiang R and Airo AM and Kobor MS and McMaster WR
DOI:
10.1371/journal.ppat.1004419
PubMed:
25299267
10 / 2014
Infinium monkeys: Infinium 450K array for the Cynomolgus macaque (Macaca fascicularis).
Ong ML and Tan PY and MacIsaac JL and Mah SM and Buschdorf JP and Cheong CY and Stunkel W and Chan L and Gluckman PD and Chng K and Kobor MS and Meaney MJ and Holbrook JD
DOI:
10.1534/g3.114.010967
PubMed:
24815017
07 / 2014
The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes.
Teh AL and Pan H and Chen L and Ong ML and Dogra S and Wong J and MacIsaac JL and Mah SM and McEwen LM and Saw SM and Godfrey KM and Chong YS and Kwek K and Kwoh CK and Soh SE and Chong MF and Barton S and Karnani N and Cheong CY and Buschdorf JP
DOI:
10.1101/gr.171439.113
PubMed:
24709820
07 / 2014
Conditional genetic interactions of RTT107, SLX4, and HRQ1 reveal dynamic networks upon DNA damage in S. cerevisiae.
Leung GP and Aristizabal MJ and Krogan NJ and Kobor MS
DOI:
10.1534/g3.114.011205
PubMed:
24700328
06 / 2014
Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling.
Rossetto D and Cramet M and Wang AY and Steunou AL and Lacoste N and Schulze JM and Ct V and Monnet-Saksouk J and Piquet S and Nourani A and Kobor MS and Ct J
DOI:
10.15252/embj.201386433
PubMed:
24843044
06 / 2014
Associations between bacterial communities of house dust and infant gut.
Konya T and Koster B and Maughan H and Escobar M and Azad MB and Guttman DS and Sears MR and Becker AB and Brook JR and Takaro TK and Kozyrskyj AL and Scott JA and CHILD Study Investigators
DOI:
10.1016/j.envres.2014.02.005
PubMed:
24637181
05 / 2014
Maintenance of heterochromatin boundary and nucleosome composition at promoters by the Asf1 histone chaperone and SWR1-C chromatin remodeler in Saccharomyces cerevisiae.
Lu PY and Kobor MS
DOI:
10.1534/genetics.114.162909
PubMed:
24578349
05 / 2014
Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip.
Chan YA and Aristizabal MJ and Lu PY and Luo Z and Hamza A and Kobor MS and Stirling PC and Hieter P
DOI:
10.1371/journal.pgen.1004288
PubMed:
24743342
04 / 2014
Spread of X-chromosome inactivation into autosomal sequences: role for DNA elements, chromatin features and chromosomal domains.
Cotton AM and Chen CY and Lam LL and Wasserman WW and Kobor MS and Brown CJ
DOI:
10.1093/hmg/ddt513
PubMed:
24158853
03 / 2014
DaVIE: Database for the Visualization and Integration of Epigenetic data.
Fejes AP and Jones MJ and Kobor MS
DOI:
10.3389/fgene.2014.00325
PubMed:
25278960
The era of integrative genomics: more data or better methods?
Koestler DC and Jones MJ and Kobor MS
DOI:
10.2217/epi.14.44
PubMed:
25431938
Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics.
Jiang R and Jones MJ and Sava F and Kobor MS and Carlsten C
DOI:
10.1186/s12989-014-0071-3
PubMed:
25487561
Genomewide DNA methylation dynamics upon diesel exhaust exposure in asthmatics.
Jiang R and Sava F and Kobor MS and Carlsten CR
Molecular pathways underpinning ethanol-induced neurodegeneration.
Goldowitz D and Lussier AA and Boyle JK and Wong K and Lattimer SL and Dubose C and Lu L and Kobor MS and Hamre KM
DOI:
10.3389/fgene.2014.00203
PubMed:
25076964
Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via -adrenergic induction of myelopoiesis.
Powell ND and Sloan EK and Bailey MT and Arevalo JM and Miller GE and Chen E and Kobor MS and Reader BF and Sheridan JF and Cole SW
DOI:
10.1073/pnas.1310655110
PubMed:
24062448
10 / 2013
High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8.
Aristizabal MJ and Negri GL and Benschop JJ and Holstege FC and Krogan NJ and Kobor MS
DOI:
10.1371/journal.pgen.1003758
PubMed:
24009531
08 / 2013
Reply to Suderman et al.: Importance of accounting for blood cell composition in epigenetic studies.
Lam LL and Emberly E and Fraser HB and Neumann SM and Chen E and Miller GE and Kobor MS
DOI:
10.1073/pnas.1222104110
PubMed:
23667927
04 / 2013
Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months.
Azad MB and Konya T and Maughan H and Guttman DS and Field CJ and Chari RS and Sears MR and Becker AB and Scott JA and Kozyrskyj AL and CHILD Study Investigators
DOI:
10.1503/cmaj.121189
PubMed:
23401405
03 / 2013
The molecular mechanism of a cis-regulatory adaptation in yeast.
Chang J and Zhou Y and Hu X and Lam L and Henry C and Green EM and Kita R and Kobor MS and Fraser HB
DOI:
10.1371/journal.pgen.1003813
PubMed:
24068973
Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array.
Price ME and Cotton AM and Lam LL and Farr P and Emberly E and Brown CJ and Robinson WP and Kobor MS
DOI:
10.1186/1756-8935-6-4
PubMed:
23452981
Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence.
Essex MJ and Boyce WT and Hertzman C and Lam LL and Armstrong JM and Neumann SM and Kobor MS
DOI:
10.1111/j.1467-8624.2011.01641.x
PubMed:
21883162
Distinct DNA methylation patterns of cognitive impairment and trisomy 21 in Down syndrome.
Jones MJ and Farr P and McEwen LM and Macisaac JL and Watt K and Neumann SM and Emberly E and Cynader MS and Virji-Babul N and Kobor MS
DOI:
10.1186/1755-8794-6-58
PubMed:
24373378
DNA methylation, genotype and gene expression: who is driving and who is along for the ride?
Jones MJ and Fejes AP and Kobor MS
DOI:
10.1186/gb-2013-14-7-126
PubMed:
23899167
Histone H3K4 demethylation is negatively regulated by histone H3 acetylation in Saccharomyces cerevisiae.
Maltby VE and Martin BJ and Brind'Amour J and Chruscicki AT and McBurney KL and Schulze JM and Johnson IJ and Hills M and Hentrich T and Kobor MS and Lorincz MC and Howe LJ
DOI:
10.1073/pnas.1202070109
PubMed:
23091032
11 / 2012
Factors underlying variable DNA methylation in a human community cohort.
Lam LL and Emberly E and Fraser HB and Neumann SM and Chen E and Miller GE and Kobor MS
DOI:
10.1073/pnas.1121249109
PubMed:
23045638
10 / 2012
Histone H3 lysine 36 methylation targets the Isw1b remodeling complex to chromatin.
Maltby VE and Martin BJ and Schulze JM and Johnson I and Hentrich T and Sharma A and Kobor MS and Howe L
DOI:
10.1128/MCB.00389-12
PubMed:
22751925
09 / 2012
p300/CBP-associated factor selectively regulates the extinction of conditioned fear.
Wei W and Coelho CM and Li X and Marek R and Yan S and Anderson S and Meyers D and Mukherjee C and Sbardella G and Castellano S and Milite C and Rotili D and Mai A and Cole PA and Sah P and Kobor MS and Bredy TW
DOI:
10.1523/JNEUROSCI.0178-12.2012
PubMed:
22933779
08 / 2012
Different measures of "genome-wide" DNA methylation exhibit unique properties in placental and somatic tissues.
Price EM and Cotton AM and Peaherrera MS and McFadden DE and Kobor MS and Robinson W
DOI:
10.4161/epi.20221
PubMed:
22531475
06 / 2012
CHROMATRA: a Galaxy tool for visualizing genome-wide chromatin signatures.
Hentrich T and Schulze JM and Emberly E and Kobor MS
DOI:
10.1093/bioinformatics/bts007
PubMed:
22238257
03 / 2012
19p13.2 microduplication causes a Sotos syndrome-like phenotype and alters gene expression.
Lehman AM and du Souich C and Chai D and Eydoux P and Huang JL and Fok AK and Avila L and Swingland J and Delaney AD and McGillivray B and Goldowitz D and Argiropoulos B and Kobor MS and Boerkoel CF
DOI:
10.1111/j.1399-0004.2010.01615.x
PubMed:
21204797
01 / 2012
R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants.
Stirling PC and Chan YA and Minaker SW and Aristizabal MJ and Barrett I and Sipahimalani P and Kobor MS and Hieter P
DOI:
10.1101/gad.179721.111
PubMed:
22279048
01 / 2012
Population-specificity of human DNA methylation.
Fraser HB and Lam LL and Neumann SM and Kobor MS
DOI:
10.1186/gb-2012-13-2-r8
PubMed:
22322129
DNA methylation profiles of airway epithelial cells and PBMCs from healthy, atopic and asthmatic children.
Stefanowicz D and Hackett TL and Garmaroudi FS and Gnther OP and Neumann S and Sutanto EN and Ling KM and Kobor MS and Kicic A and Stick SM and Par PD and Knight DA
DOI:
10.1371/journal.pone.0044213
PubMed:
22970180
Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123.
Schulze JM and Hentrich T and Nakanishi S and Gupta A and Emberly E and Shilatifard A and Kobor MS
DOI:
10.1101/gad.177220.111
PubMed:
22056669
11 / 2011
The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory.
Lin Q and Wei W and Coelho CM and Li X and Baker-Andresen D and Dudley K and Ratnu VS and Boskovic Z and Kobor MS and Sun YE and Bredy TW
DOI:
10.1038/nn.2891
PubMed:
21841775
09 / 2011
Key functional regions in the histone variant H2A.Z C-terminal docking domain.
Wang AY and Aristizabal MJ and Ryan C and Krogan NJ and Kobor MS
DOI:
10.1128/MCB.05182-11
PubMed:
21791612
09 / 2011
Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation.
Cotton AM and Lam L and Affleck JG and Wilson IM and Peaherrera MS and McFadden DE and Kobor MS and Lam WL and Robinson WP and Brown CJ
DOI:
10.1007/s00439-011-1007-8
PubMed:
21597963
08 / 2011
Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood.
Chen E and Miller GE and Kobor MS and Cole SW
DOI:
10.1038/mp.2010.53
PubMed:
20479762
07 / 2011
Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks.
Leung GP and Lee L and Schmidt TI and Shirahige K and Kobor MS
DOI:
10.1074/jbc.M111.235200
PubMed:
21642432
07 / 2011
Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders.
Dudley KJ and Li X and Kobor MS and Kippin TE and Bredy TW
DOI:
10.1016/j.neubiorev.2010.12.016
PubMed:
21251925
06 / 2011
The specificity and topology of chromatin interaction pathways in yeast.
Lenstra TL and Benschop JJ and Kim T and Schulze JM and Brabers NA and Margaritis T and van de Pasch LA and van Heesch SA and Brok MO and Groot Koerkamp MJ and Ko CW and van Leenen D and Sameith K and van Hooff SR and Lijnzaad P and Kemmeren P and Hentrich T and Kobor MS and Buratowski S and Holstege FC
DOI:
10.1016/j.molcel.2011.03.026
PubMed:
21596317
05 / 2011
Dot1 and histone H3K79 methylation in natural telomeric and HM silencing.
Takahashi YH and Schulze JM and Jackson J and Hentrich T and Seidel C and Jaspersen SL and Kobor MS and Shilatifard A
DOI:
10.1016/j.molcel.2011.03.006
PubMed:
21474073
04 / 2011
Fetal alcohol spectrum disorders: gene-environment interactions, predictive biomarkers, and the relationship between structural alterations in the brain and functional outcomes.
Reynolds JN and Weinberg J and Clarren S and Beaulieu C and Rasmussen C and Kobor M and Dube MP and Goldowitz D
DOI:
10.1016/j.spen.2011.02.006
PubMed:
21575841
03 / 2011
Focus on: epigenetics and fetal alcohol spectrum disorders.
Kobor MS and Weinberg J
PubMed:
23580038
Extensive epigenetic reprogramming in human somatic tissues between fetus and adult.
Yuen RK and Neumann SM and Fok AK and Peaherrera MS and McFadden DE and Robinson WP and Kobor MS
DOI:
10.1186/1756-8935-4-7
PubMed:
21545704
Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway.
Lvesque N and Leung GP and Fok AK and Schmidt TI and Kobor MS
DOI:
10.1074/jbc.M110.116855
PubMed:
20810656
11 / 2010
Reading chromatin: insights from yeast into YEATS domain structure and function.
Schulze JM and Wang AY and Kobor MS
DOI:
10.4161/epi.5.7.12856
PubMed:
20657183
10 / 2010
Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium.
Kicic A and Hallstrand TS and Sutanto EN and Stevens PT and Kobor MS and Taplin C and Par PD and Beyer RP and Stick SM and Knight DA
DOI:
10.1164/rccm.200907-1071OC
PubMed:
20110557
05 / 2010
How the epigenome contributes to the development of psychiatric disorders.
Bredy TW and Sun YE and Kobor MS
DOI:
10.1002/dev.20424
PubMed:
20127889
05 / 2010
Roles for H2A.Z and its acetylation in GAL1 transcription and gene induction, but not GAL1-transcriptional memory.
Halley JE and Kaplan T and Wang AY and Kobor MS and Rine J
DOI:
10.1371/journal.pbio.1000401
PubMed:
20582323
Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation.
Wang AY and Schulze JM and Skordalakes E and Gin JW and Berger JM and Rine J and Kobor MS
DOI:
10.1073/pnas.0906539106
PubMed:
19966225
12 / 2009
NuA4 and SWR1-C: two chromatin-modifying complexes with overlapping functions and components.
Lu PY and Lvesque N and Kobor MS
DOI:
10.1139/O09-062
PubMed:
19898529
10 / 2009
Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation.
Schulze JM and Jackson J and Nakanishi S and Gardner JM and Hentrich T and Haug J and Johnston M and Jaspersen SL and Kobor MS and Shilatifard A
DOI:
10.1016/j.molcel.2009.07.017
PubMed:
19682934
09 / 2009
Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling.
Miller GE and Chen E and Fok AK and Walker H and Lim A and Nicholls EF and Cole S and Kobor MS
DOI:
10.1073/pnas.0902971106
PubMed:
19617551
08 / 2009
H2A.Z and DNA methylation: irreconcilable differences.
Kobor MS and Lorincz MC
DOI:
10.1016/j.tibs.2008.12.006
PubMed:
19282182
04 / 2009
YEATS domain proteins: a diverse family with many links to chromatin modification and transcription.
Schulze JM and Wang AY and Kobor MS
DOI:
10.1139/O08-111
PubMed:
19234524
02 / 2009
Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes.
Yuen RK and Avila L and Peaherrera MS and von Dadelszen P and Lefebvre L and Kobor MS and Robinson WP
DOI:
10.1371/journal.pone.0007389
PubMed:
19838307
Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4.
Roberts TM and Kobor MS and Bastin-Shanower SA and Ii M and Horte SA and Gin JW and Emili A and Rine J and Brill SJ and Brown GW
DOI:
10.1091/mbc.E05-08-0785
PubMed:
16267268
01 / 2006
NMR structure of the amino-terminal domain from the Tfb1 subunit of TFIIH and characterization of its phosphoinositide and VP16 binding sites.
Di Lello P and Nguyen BD and Jones TN and Potempa K and Kobor MS and Legault P and Omichinski JG
DOI:
10.1021/bi050099s
PubMed:
15909982
05 / 2005
Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator.
Kong SE and Kobor MS and Krogan NJ and Somesh BP and Sgaard TM and Greenblatt JF and Svejstrup JQ
DOI:
10.1074/jbc.M411071200
PubMed:
15563457
02 / 2005
Dephosphorylation of RNA polymerase I by Fcp1p is required for efficient rRNA synthesis.
Fath S and Kobor MS and Philippi A and Greenblatt J and Tschochner H
DOI:
10.1074/jbc.M401867200
PubMed:
15073185
06 / 2004
A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin.
Kobor MS and Venkatasubrahmanyam S and Meneghini MD and Gin JW and Jennings JL and Link AJ and Madhani HD and Rine J
DOI:
10.1371/journal.pbio.0020131
PubMed:
15045029
05 / 2004
NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1.
Nguyen BD and Abbott KL and Potempa K and Kobor MS and Archambault J and Greenblatt J and Legault P and Omichinski JG
DOI:
10.1073/pnas.1031524100
PubMed:
12732728
05 / 2003
Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB.
Nguyen BD and Chen HT and Kobor MS and Greenblatt J and Legault P and Omichinski JG
DOI:
10.1021/bi0265473
PubMed:
12578358
02 / 2003
Purification and assay of Saccharomyces cerevisiae phosphatase that acts on the C-terminal domain of the largest subunit of RNA polymerase II.
Hoheisel S and Kobor MS and Pierstorff E and Greenblatt J and Kane CM
DOI:
10.1016/S0076-6879(03)70034-2
PubMed:
14712662
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach.
Krogan NJ and Kim M and Ahn SH and Zhong G and Kobor MS and Cagney G and Emili A and Shilatifard A and Buratowski S and Greenblatt JF
DOI:
10.1128/MCB.22.20.6979-6992.2002
PubMed:
12242279
10 / 2002
Regulation of transcription elongation by phosphorylation.
Kobor MS and Greenblatt J
DOI:
10.1016/S0167-4781(02)00457-8
PubMed:
12213657
09 / 2002
Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain.
Cho EJ and Kobor MS and Kim M and Greenblatt J and Buratowski S
DOI:
10.1101/gad.935901
PubMed:
11751637
12 / 2001
A motif shared by TFIIF and TFIIB mediates their interaction with the RNA polymerase II carboxy-terminal domain phosphatase Fcp1p in Saccharomyces cerevisiae.
Kobor MS and Simon LD and Omichinski J and Zhong G and Archambault J and Greenblatt J
DOI:
10.1128/MCB.20.20.7438-7449.2000
PubMed:
11003641
10 / 2000
An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.
Kobor MS and Archambault J and Lester W and Holstege FC and Gileadi O and Jansma DB and Jennings EG and Kouyoumdjian F and Davidson AR and Young RA and Greenblatt J
DOI:
10.1016/S1097-2765(00)80187-2
PubMed:
10445027
07 / 1999
GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8.
Hirst M and Kobor MS and Kuriakose N and Greenblatt J and Sadowski I
DOI:
10.1016/S1097-2765(00)80360-3
PubMed:
10360183
05 / 1999
An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae.
Archambault J and Chambers RS and Kobor MS and Ho Y and Cartier M and Bolotin D and Andrews B and Kane CM and Greenblatt J
DOI:
10.1073/pnas.94.26.14300
PubMed:
9405607
12 / 1997
Identification of a nucleic acid-binding region within the largest subunit of Drosophila melanogaster RNA polymerase II.
Kontermann RE and Kobor M and Bautz EK
DOI:
10.1002/pro.5560020211
PubMed:
8443600
02 / 1993
