Overview

As the sole carrier of genetic information, DNA does not exist as a naked template in the eukaryotic genome; instead DNA exists as a chromatin structure amenable to the changing environment, especially during the sensitive period of childhood. Not surprisingly, many complex regulatory mechanisms act on chromatin to ensure that each cell expresses only the appropriate genes, duplicates its genome with high fidelity, divides only when required, and combats constant assaults on its DNA.

Failure in any of the mechanisms regulating these events can lead to a wide range of outcomes from altered developmental trajectories to complex diseases. Furthermore, a number of chromatin modifying proteins are involved in genetic susceptibility to diseases. The objective of our research is to understand the molecular mechanisms of epigenetic regulation in response to the environment. This is largely achieved through evaluating DNA methylation, histone variants, post-translational modification of histone, and nucleosome positioning. Additionally, genetic variation may interact with specific environments, imparting sensitivity or resilience, to ultimately alter epigenetics patterns and phenotypic outcomes.

Publications

Reproduction predicts shorter telomeres and epigenetic age acceleration among young adult women
Scientific Reports
Calen P. Ryan, M. Geoffrey Hayes, Nanette R. Lee, Thomas W. McDade, Meaghan J. Jones, Michael S. Kobor, Christopher W. Kuzawa, Dan T. A. Eisenberg
DOI: 10.1038/s41598-018-29486-4
12/2018

Early-life socioeconomic disadvantage, not current, predicts accelerated epigenetic aging of monocytes
Psychoneuroendocrinology
Makeda K. Austin, Edith Chen, Kharah M. Ross, Lisa M. McEwen, Julia L. Maclsaac, Michael S. Kobor, Gregory E. Miller
DOI: 10.1016/j.psyneuen.2018.07.007
11/2018

Variability in DNA methylation at the serotonin transporter gene promoter: epigenetic mechanism or cell-type artifact?
Molecular Psychiatry
Sarah R. Moore, Michael S. Kobor
DOI: 10.1038/s41380-018-0121-6
08/2018

Exploring the Genetic Basis of Human Population Differences in DNA Methylation and their Causal Impact on Immune Gene Regulation
Lucas Theo Husquin, Maxime Rotival, Maud Fagny, Helene Quach, Nora Zidane, Lisa M McEwen, Julia L MacIsaac, Michael S Kobor, Hugues Aschard, Etienne Patin, Lluis Quintana-Murci
DOI: 10.1101/371872
07/2018

DNA methylation signatures in peripheral blood mononuclear cells from a lifestyle intervention for women at midlife: a pilot randomized controlled trial.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
McEwen LM, Gatev EG, Jones MJ, MacIsaac JL, McAllister MM, Goulding RE, Madden KM, Dawes MG, Kobor MS, Ashe MC
DOI: 10.1139/apnm-2017-0436
PubMed: 29049890
03/2018

Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study.
The Journal of allergy and clinical immunology
Tran MM, Lefebvre DL, Dharma C, Dai D, Lou WYW, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Sears MR, Canadian Healthy Infant Longitudinal Development Study investigators
DOI: 10.1016/j.jaci.2017.08.024
PubMed: 29153857
02/2018

Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Dharma C, Lefebvre DL, Tran MM, Lou WYW, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Sears MR, CHILD Study investigators
DOI: 10.1111/cea.13063
PubMed: 29143385
01/2018

DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up.
Translational psychiatry
O'Donnell KJ, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Meaney MJ
DOI: 10.1038/s41398-017-0063-9
PubMed: 29317599
01/2018

Healthy Foundations Study: a randomised controlled trial to evaluate biological embedding of early-life experiences.
BMJ open
Gonzalez A, Catherine N, Boyle M, Jack SM, Atkinson L, Kobor M, Sheehan D, Tonmyr L, Waddell C, MacMillan HL, Healthy Foundations Study Team
DOI: 10.1136/bmjopen-2017-018915
PubMed: 29374668
01/2018

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD.
Clinical epigenetics
Clifford RL, Fishbane N, Patel J, MacIsaac JL, McEwen LM, Fisher AJ, Brandsma CA, Nair P, Kobor MS, Hackett TL, Knox AJ
DOI: 10.1186/s13148-018-0464-5
PubMed: 29527240
2018

Epigenetic analysis of human postmortem brain tissue.
Handbook of clinical neurology
Islam SA, Lussier AA, Kobor MS
DOI: 10.1016/b978-0-444-63639-3.00017-7
PubMed: 29496144
2018

DNA methylation as a predictor of fetal alcohol spectrum disorder.
Clinical epigenetics
Lussier AA, Morin AM, MacIsaac JL, Salmon J, Weinberg J, Reynolds JN, Pavlidis P, Chudley AE, Kobor MS
DOI: 10.1186/s13148-018-0439-6
PubMed: 29344313
2018

Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time.
Epigenetics
Forest M, O'Donnell KJ, Voisin G, Gaudreau H, MacIsaac JL, McEwen LM, Silveira PP, Steiner M, Kobor MS, Meaney MJ, Greenwood CMT
DOI: 10.1080/15592294.2017.1411443
PubMed: 29381404
2018

Choice of surrogate tissue influences neonatal EWAS findings.
BMC medicine
Lin X, Teh AL, Chen L, Lim IY, Tan PF, MacIsaac JL, Morin AM, Yap F, Tan KH, Saw SM, Lee YS, Holbrook JD, Godfrey KM, Meaney MJ, Kobor MS, Chong YS, Karnani N
DOI: 10.1186/s12916-017-0970-x
PubMed: 29202839
12/2017

Epigenetic correlates of neonatal contact in humans.
Development and psychopathology
Moore SR, McEwen LM, Quirt J, Morin A, Mah SM, Barr RG, Boyce WT, Kobor MS
DOI: 10.1017/s0954579417001213
PubMed: 29162165
12/2017

DNA methylation signatures of chronic alcohol dependence in purified CD3+ T-cells of patients undergoing alcohol treatment
Scientific Reports
Christof Brückmann, Sumaiya A. Islam, Julia L. MacIsaac, Alexander M. Morin, Kathrin N. Karle, Adriana Di Santo, Richard Wüst, Immanuel Lang, Anil Batra, Michael S. Kobor, Vanessa Nieratschker
DOI: 10.1038/s41598-017-06847-z
12/2017

Modes of Infant Feeding and the Risk of Childhood Asthma: A Prospective Birth Cohort Study.
The Journal of pediatrics
Klopp A, Vehling L, Becker AB, Subbarao P, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR, CHILD Study Investigators, Azad MB
DOI: 10.1016/j.jpeds.2017.07.012
PubMed: 29144244
11/2017

Birth weight and postnatal microbial exposures predict the distribution of peripheral blood leukocyte subsets in young adults in the Philippines.
Journal of developmental origins of health and disease
DOI: 10.1017/s2040174417000794
PubMed: 29017617
10/2017

DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly.
Experimental gerontology
DOI: 10.1016/j.exger.2017.10.010
PubMed: 29032243
10/2017

Principles and Challenges of Applying Epigenetic Epidemiology to Psychology.
Annual review of psychology
DOI: 10.1146/annurev-psych-122414-033653
PubMed: 29035689
10/2017

RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.
The Journal of cell biology
DOI: 10.1083/jcb.201703168
PubMed: 29042409
10/2017

Worldwide patterns of human epigenetic variation
Nature Ecology & Evolution
Oana Carja, Julia L. MacIsaac, Sarah M. Mah, Brenna M. Henn, Michael S. Kobor, Marcus W. Feldman, Hunter B. Fraser
DOI: 10.1038/s41559-017-0299-z
10/2017

Exploring genetic influences underlying acute aerobic exercise effects on motor learning.
Scientific reports
DOI: 10.1038/s41598-017-12422-3
PubMed: 28935933
09/2017

Accelerated DNA methylation age in adolescent girls: associations with elevated diurnal cortisol and reduced hippocampal volume.
Translational psychiatry
DOI: 10.1038/tp.2017.188
PubMed: 28850111
08/2017

Timing of food introduction and development of food sensitization in a prospective birth cohort.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
DOI: 10.1111/pai.12739
PubMed: 28557044
08/2017

BECon: a tool for interpreting DNA methylation findings from blood in the context of brain.
Translational psychiatry
DOI: 10.1038/tp.2017.171
PubMed: 28763057
08/2017

Trends in DNA Methylation with Age Replicate Across Diverse Human Populations.
Genetics
DOI: 10.1534/genetics.116.195594
PubMed: 28533441
07/2017

Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood.
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1620661114
PubMed: 28673994
07/2017

Blood and nasal epigenetics correlate with allergic rhinitis symptom development in the environmental exposure unit.
Allergy
DOI: 10.1111/all.13263
PubMed: 28755526
07/2017

The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study.
BMC genetics
DOI: 10.1186/s12863-017-0525-3
PubMed: 28637423
06/2017

The Intersection Of Aging Biology and The Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.
Budinger GS, Kohanski RA, Gan W, Kobor MS, Amaral LA, Armanios M, Kelsey KT, Pardo A, Tuder R, Macian F, Chandel N, Vaughan D, Rojas M, Mora AL, Kovacs E, Duncan SR, Finkel T, Choi A, Eickelberg O, Chen D, dummy-AUTHOR_name, Thannickal VJ
DOI: 10.1093/gerona/glx090
PubMed: 28498894
05/2017

Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios.
Tun HM, Konya T, Takaro TK, Brook JR, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL, CHILD Study Investigators
DOI: 10.1186/s40168-017-0254-x
PubMed: 28381231
04/2017

Epigenetics studies of fetal alcohol spectrum disorder: where are we now?
Lussier AA, Weinberg J, Kobor MS
DOI: 10.2217/epi-2016-0163
PubMed: 28234026
03/2017

Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome.
Lin X, Lim IY, Wu Y, Teh AL, Chen L, Aris IM, Soh SE, Tint MT, MacIsaac JL, Morin AM, Yap F, Tan KH, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Holbrook JD, Lee YS, Gluckman PD
DOI: 10.1186/s12916-017-0800-1
PubMed: 28264723
03/2017

Longitudinal study of surrogate aging measures during human immunodeficiency virus seroconversion.
Leung JM, Fishbane N, Jones M, Morin A, Xu S, Liu JC, MacIsaac J, Milloy MJ, Hayashi K, Montaner J, Horvath S, Kobor M, Sin DD, Harrigan PR, Man SF
DOI: 10.18632/aging.101184
PubMed: 28237978
02/2017

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation.
Clifford RL, Jones MJ, MacIsaac JL, McEwen LM, Goodman SJ, Mostafavi S, Kobor MS, Carlsten C
DOI: 10.1016/j.jaci.2016.03.046
PubMed: 27321436
01/2017

An empirically driven data reduction method on the human 450K methylation array to remove tissue specific non-variable CpGs.
Edgar RD, Jones MJ, Robinson WP, Kobor MS
DOI: 10.1186/s13148-017-0320-z
PubMed: 28184257
2017

Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region.
McEwen LM, Morin AM, Edgar RD, MacIsaac JL, Jones MJ, Dow WH, Rosero-Bixby L, Kobor MS, Rehkopf DH
DOI: 10.1186/s13072-017-0128-2
PubMed: 28465725
2017

Fecal Short-Chain Fatty Acid Variations by Breastfeeding Status in Infants at 4¿Months: Differences in Relative versus Absolute Concentrations.
Bridgman SL, Azad MB, Field CJ, Haqq AM, Becker AB, Mandhane PJ, Subbarao P, Turvey SE, Sears MR, Scott JA, Wishart DS, Kozyrskyj AL, CHILD Study Investigators
DOI: 10.3389/fnut.2017.00011
PubMed: 28443284
2017

Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth.
Girchenko P, Lahti J, Czamara D, Knight AK, Jones MJ, Suarez A, Hämäläinen E, Kajantie E, Laivuori H, Villa PM, Reynolds RM, Kobor MS, Smith AK, Binder EB, Räikkönen K
DOI: 10.1186/s13148-017-0349-z
PubMed: 28503212
2017

Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs.
Clinical epigenetics
DOI: 10.1186/s13148-017-0370-2
PubMed: 28770015
2017

Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy.
Frontiers in Pediatrics
DOI: 10.3389/fped.2017.00200
PubMed: 29018787
2017

Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome.
Steunou AL, Cramet M, Rossetto D, Aristizabal MJ, Lacoste N, Drouin S, Côté V, Paquet E, Utley RT, Krogan N, Robert F, Kobor MS, Côté J
DOI: 10.1128/mcb.00112-16
PubMed: 27550811
11/2016

Genome-wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up.
Gref A, Kebede Merid S, Gruzieva O, Ballereau S, Becker A, Bellander T, Bergström A, Bossé Y, Bottai M, Chan-Yeung M, Fuertes E, Ierodiakonou D, Jiang R, Joly S, Jones M, Kobor MS, Korek M, Kozyrskyj AL, Kumar A, Lemonnier N
PubMed: 27901618
11/2016

An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.
Horvath S, Gurven M, Levine ME, Trumble BC, Kaplan H, Allayee H, Ritz BR, Chen B, Lu AT, Rickabaugh TM, Jamieson BD, Sun D, Li S, Chen W, Quintana-Murci L, Fagny M, Kobor MS, Tsao PS, Reiner AP, Edlefsen KL
DOI: 10.1186/s13059-016-1030-0
PubMed: 27511193
08/2016

Epigenetics: A New Model for Intracellular Parasite-Host Cell Regulation.
Robert McMaster W, Morrison CJ, Kobor MS
DOI: 10.1016/j.pt.2016.04.002
PubMed: 27142564
04/2016

DNA Methylation Profiling in Human Huntington's Disease Brain.
De Souza RA, Islam SA, McEwen LM, Mathelier A, Hill A, Mah SM, Wasserman WW, Kobor MS, Leavitt BR
PubMed: 26953320
03/2016

Low birth weight associates with hippocampal gene expression.
Buschdorf JP, Ong ML, Ong SX, MacIsaac JL, Chng K, Kobor MS, Meaney MJ, Holbrook JD
DOI: 10.1016/j.neuroscience.2016.01.013
PubMed: 26791528
03/2016

A single flexible RNAPII-CTD integrates many different transcriptional programs.
Aristizabal MJ, Kobor MS
DOI: 10.1080/21541264.2016.1163451
PubMed: 26985717
03/2016

funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types.
Oros Klein K, Grinek S, Bernatsky S, Bouchard L, Ciampi A, Colmegna I, Fortin JP, Gao L, Hivert MF, Hudson M, Kobor MS, Labbe A, MacIsaac JL, Meaney MJ, Morin AM, O'Donnell KJ, Pastinen T, Van Ijzendoorn MH, Voisin G, Greenwood CM
DOI: 10.1093/bioinformatics/btv615
PubMed: 26500152
02/2016

Infant gut immunity: a preliminary study of IgA associations with breastfeeding.
Bridgman SL, Konya T, Azad MB, Sears MR, Becker AB, Turvey SE, Mandhane PJ, Subbarao P, CHILD Study Investigators, Scott JA, Field CJ, Kozyrskyj AL
DOI: 10.1017/S2040174415007862
PubMed: 26690933
02/2016

Differential DNA methylation in peripheral blood mononuclear cells in adolescents exposed to significant early but not later childhood adversity.
Esposito EA, Jones MJ, Doom JR, MacIsaac JL, Gunnar MR, Kobor MS
PubMed: 26847422
02/2016

Rtt107 BRCT domains act as a targeting module in the DNA damage response.
Leung GP, Brown JA, Glover JN, Kobor MS
DOI: 10.1016/j.dnarep.2015.10.007
PubMed: 26641499
01/2016

Comparison of Methyl-capture Sequencing vs. Infinium 450K methylation array for methylome analysis in clinical samples.
Teh AL, Pan H, Lin X, Lim YI, Patro CP, Cheong CY, Gong M, MacIsaac JL, Kwoh CK, Meaney MJ, Kobor MS, Chong YS, Gluckman PD, Holbrook JD, Karnani N
DOI: 10.1080/15592294.2015.1132136
PubMed: 26786415
01/2016

Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats.
Beery AK, McEwen LM, MacIsaac JL, Francis DD, Kobor MS
DOI: 10.1016/j.yhbeh.2015.05.022
PubMed: 26122287
01/2016

Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL).
Koestler DC, Jones MJ, Usset J, Christensen BC, Butler RA, Kobor MS, Wiencke JK, Kelsey KT
DOI: 10.1186/s12859-016-0943-7
PubMed: 26956433
2016

DNA methylation signature of human fetal alcohol spectrum disorder.
Portales-Casamar E, Lussier AA, Jones MJ, MacIsaac JL, Edgar RD, Mah SM, Barhdadi A, Provost S, Lemieux-Perreault LP, Cynader MS, Chudley AE, Dubé MP, Reynolds JN, Pavlidis P, Kobor MS
DOI: 10.1186/s13072-016-0074-4
PubMed: 27358653
2016

AllerGen’s 8th research conference.
Arrieta M, Arevalos A, Stiemsma L, Chico ME, Sandoval C, Jin M, Walter J, Cooper P, Finlay B, Bernatchez E, Gold MJ, Langlois A, Blais-Lecours P, Duchaine C, Marsolais D, McNagny KM, Blanchet M, Brubacher J, Chhetri B, Sabaliauskas K
2016

DNA methylation and healthy human aging.
Jones MJ, Goodman SJ, Kobor MS
DOI: 10.1111/acel.12349
PubMed: 25913071
12/2015

Bacterial infection remodels the DNA methylation landscape of human dendritic cells.
Pacis A, Tailleux L, Morin AM, Lambourne J, MacIsaac JL, Yotova V, Dumaine A, Danckaert A, Luca F, Grenier JC, Hansen KD, Gicquel B, Yu M, Pai A, He C, Tung J, Pastinen T, Kobor MS, Pique-Regi R, Gilad Y
DOI: 10.1101/gr.192005.115
PubMed: 26392366
12/2015

Maternal early life adversities and the offspring's epigenome: A M.A.V.A.N. project.
Unternaehrer E, O'Donnell K, Bouvette-Turcot AA, Gaudreau H, Cost K, Fleming A, Steiner M, MacIsaac J, Mah S, McEwen L, Kobor M, Chen L, Pan H, Hui WY, Holbrook J, Meaney M, Study Team MAVAN
DOI: 10.1016/j.psyneuen.2015.07.477
PubMed: 26383363
11/2015

The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition.
Aristizabal MJ, Negri GL, Kobor MS
DOI: 10.1371/journal.pgen.1005608
PubMed: 26496706
10/2015

The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma.
Subbarao P, Anand SS, Becker AB, Befus AD, Brauer M, Brook JR, Denburg JA, HayGlass KT, Kobor MS, Kollmann TR, Kozyrskyj AL, Lou WY, Mandhane PJ, Miller GE, Moraes TJ, Pare PD, Scott JA, Takaro TK, Turvey SE, Duncan JM
DOI: 10.1136/thoraxjnl-2015-207246
PubMed: 26069286
10/2015

Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.
Azad MB, Konya T, Persaud RR, Guttman DS, Chari RS, Field CJ, Sears MR, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL, CHILD Study Investigators
PubMed: 26412384
09/2015

Prenatal alcohol exposure alters gene expression in the rat brain: Experimental design and bioinformatic analysis of microarray data.
Lussier AA, Stepien KA, Weinberg J, Kobor MS
DOI: 10.1016/j.dib.2015.05.007
PubMed: 26217797
09/2015

Adjusting for Cell Type Composition in DNA Methylation Data Using a Regression-Based Approach.
Jones MJ, Islam SA, Edgar RD, Kobor MS
DOI: 10.1007/7651_2015_262
PubMed: 26126446
07/2015

A pooling-based approach to mapping genetic variants associated with DNA methylation.
Kaplow IM, MacIsaac JL, Mah SM, McEwen LM, Kobor MS, Fraser HB
DOI: 10.1101/gr.183749.114
PubMed: 25910490
06/2015

Landscape of DNA methylation on the X chromosome reflects CpG density, functional chromatin state and X-chromosome inactivation.
Cotton AM, Price EM, Jones MJ, Balaton BP, Kobor MS, Brown CJ
DOI: 10.1093/hmg/ddu564
PubMed: 25381334
03/2015

Infant gut microbiota and food sensitization: associations in the first year of life.
Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, HayGlass KT, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL, CHILD Study Investigators
DOI: 10.1111/cea.12487
PubMed: 25599982
03/2015

Prenatal alcohol exposure alters steady-state and activated gene expression in the adult rat brain.
Lussier AA, Stepien KA, Neumann SM, Pavlidis P, Kobor MS, Weinberg J
DOI: 10.1111/acer.12622
PubMed: 25684047
02/2015

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes.
Chen L, Pan H, Tuan TA, Teh AL, MacIsaac JL, Mah SM, McEwen LM, Li Y, Chen H, Broekman BF, Buschdorf JP, Chong YS, Kwek K, Saw SM, Gluckman PD, Fortier MV, Rifkin-Graboi A, Kobor MS, Qiu A, Meaney MJ
DOI: 10.1017/S0954579414001357
PubMed: 25640836
02/2015

Development and the epigenome: the 'synapse' of gene-environment interplay.
Boyce WT, Kobor MS
DOI: 10.1111/desc.12282
PubMed: 25546559
01/2015

The Canadian healthy infant longitudinal development birth cohort study: biological samples and biobanking.
Moraes TJ, Lefebvre DL, Chooniedass R, Becker AB, Brook JR, Denburg J, HayGlass KT, Hegele RG, Kollmann TR, Macri J, Mandhane PJ, Scott JA, Subbarao P, Takaro TK, Turvey SE, Duncan JD, Sears MR, Befus AD, CHILD Study Investigators
DOI: 10.1111/ppe.12161
PubMed: 25405552
01/2015

The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures.
Takaro TK, Scott JA, Allen RW, Anand SS, Becker AB, Befus AD, Brauer M, Duncan J, Lefebvre DL, Lou W, Mandhane PJ, McLean KE, Miller G, Sbihi H, Shu H, Subbarao P, Turvey SE, Wheeler AJ, Zeng L, Sears MR
DOI: 10.1038/jes.2015.7
PubMed: 25805254
2015

HIF3A association with adiposity: the story begins before birth.
Pan H, Lin X, Wu Y, Chen L, Teh AL, Soh SE, Lee YS, Tint MT, MacIsaac JL, Morin AM, Tan KH, Yap F, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Gluckman PD, Karnani N, Holbrook JD
DOI: 10.2217/epi.15.45
PubMed: 26011824
2015

Concordant and discordant DNA methylation signatures of aging in human blood and brain.
Farré P, Jones MJ, Meaney MJ, Emberly E, Turecki G, Kobor MS
DOI: 10.1186/s13072-015-0011-y
PubMed: 25977707
2015

Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells.
de Goede OM, Razzaghian HR, Price EM, Jones MJ, Kobor MS, Robinson WP, Lavoie PM
DOI: 10.1186/s13148-015-0129-6
PubMed: 26366232
2015

Discordance of DNA methylation variance between two accessible human tissues.
Jiang R, Jones MJ, Chen E, Neumann SM, Fraser HB, Miller GE, Kobor MS
DOI: 10.1038/srep08257
PubMed: 25660083
2015

Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates.
Gurnot C, Martin-Subero I, Mah SM, Weikum W, Goodman SJ, Brain U, Werker JF, Kobor MS, Esteller M, Oberlander TF, Hensch TK
DOI: 10.1080/15592294.2015.1026031
PubMed: 25891251
2015

The epigenomic landscape of African rainforest hunter-gatherers and farmers.
Fagny M, Patin E, MacIsaac JL, Rotival M, Flutre T, Jones MJ, Siddle KJ, Quach H, Harmant C, McEwen LM, Froment A, Heyer E, Gessain A, Betsem E, Mouguiama-Daouda P, Hombert JM, Perry GH, Barreiro LB, Kobor MS, Quintana-Murci L
DOI: 10.1038/ncomms10047
PubMed: 26616214
2015

Leishmania donovani infection causes distinct epigenetic DNA methylation changes in host macrophages.
Marr AK, MacIsaac JL, Jiang R, Airo AM, Kobor MS, McMaster WR
DOI: 10.1371/journal.ppat.1004419
PubMed: 25299267
10/2014

Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers.
Miller GE, Murphy ML, Cashman R, Ma R, Ma J, Arevalo JM, Kobor MS, Cole SW
DOI: 10.1016/j.bbi.2014.05.016
PubMed: 25242587
10/2014

Infinium monkeys: Infinium 450K array for the Cynomolgus macaque (Macaca fascicularis).
Ong ML, Tan PY, MacIsaac JL, Mah SM, Buschdorf JP, Cheong CY, Stunkel W, Chan L, Gluckman PD, Chng K, Kobor MS, Meaney MJ, Holbrook JD
DOI: 10.1534/g3.114.010967
PubMed: 24815017
07/2014

The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes.
Teh AL, Pan H, Chen L, Ong ML, Dogra S, Wong J, MacIsaac JL, Mah SM, McEwen LM, Saw SM, Godfrey KM, Chong YS, Kwek K, Kwoh CK, Soh SE, Chong MF, Barton S, Karnani N, Cheong CY, Buschdorf JP
DOI: 10.1101/gr.171439.113
PubMed: 24709820
07/2014

Conditional genetic interactions of RTT107, SLX4, and HRQ1 reveal dynamic networks upon DNA damage in S. cerevisiae.
Leung GP, Aristizabal MJ, Krogan NJ, Kobor MS
DOI: 10.1534/g3.114.011205
PubMed: 24700328
06/2014

Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling.
Rossetto D, Cramet M, Wang AY, Steunou AL, Lacoste N, Schulze JM, Côté V, Monnet-Saksouk J, Piquet S, Nourani A, Kobor MS, Côté J
DOI: 10.15252/embj.201386433
PubMed: 24843044
06/2014

Associations between bacterial communities of house dust and infant gut.
Konya T, Koster B, Maughan H, Escobar M, Azad MB, Guttman DS, Sears MR, Becker AB, Brook JR, Takaro TK, Kozyrskyj AL, Scott JA, CHILD Study Investigators
DOI: 10.1016/j.envres.2014.02.005
PubMed: 24637181
05/2014

Maintenance of heterochromatin boundary and nucleosome composition at promoters by the Asf1 histone chaperone and SWR1-C chromatin remodeler in Saccharomyces cerevisiae.
Lu PY, Kobor MS
DOI: 10.1534/genetics.114.162909
PubMed: 24578349
05/2014

Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip.
Chan YA, Aristizabal MJ, Lu PY, Luo Z, Hamza A, Kobor MS, Stirling PC, Hieter P
DOI: 10.1371/journal.pgen.1004288
PubMed: 24743342
04/2014

Spread of X-chromosome inactivation into autosomal sequences: role for DNA elements, chromatin features and chromosomal domains.
Cotton AM, Chen CY, Lam LL, Wasserman WW, Kobor MS, Brown CJ
DOI: 10.1093/hmg/ddt513
PubMed: 24158853
03/2014

The era of integrative genomics: more data or better methods?
Koestler DC, Jones MJ, Kobor MS
DOI: 10.2217/epi.14.44
PubMed: 25431938
2014

Genomewide DNA methylation dynamics upon diesel exhaust exposure in asthmatics.
Jiang R, Sava F, Kobor MS, Carlsten CR
2014

Molecular pathways underpinning ethanol-induced neurodegeneration.
Goldowitz D, Lussier AA, Boyle JK, Wong K, Lattimer SL, Dubose C, Lu L, Kobor MS, Hamre KM
DOI: 10.3389/fgene.2014.00203
PubMed: 25076964
2014

DaVIE: Database for the Visualization and Integration of Epigenetic data.
Fejes AP, Jones MJ, Kobor MS
DOI: 10.3389/fgene.2014.00325
PubMed: 25278960
2014

Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics.
Jiang R, Jones MJ, Sava F, Kobor MS, Carlsten C
DOI: 10.1186/s12989-014-0071-3
PubMed: 25487561
2014

Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via ß-adrenergic induction of myelopoiesis.
Powell ND, Sloan EK, Bailey MT, Arevalo JM, Miller GE, Chen E, Kobor MS, Reader BF, Sheridan JF, Cole SW
DOI: 10.1073/pnas.1310655110
PubMed: 24062448
10/2013

High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8.
Aristizabal MJ, Negri GL, Benschop JJ, Holstege FC, Krogan NJ, Kobor MS
DOI: 10.1371/journal.pgen.1003758
PubMed: 24009531
08/2013

Reply to Suderman et al.: Importance of accounting for blood cell composition in epigenetic studies.
Lam LL, Emberly E, Fraser HB, Neumann SM, Chen E, Miller GE, Kobor MS
DOI: 10.1073/pnas.1222104110
PubMed: 23667927
04/2013

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months.
Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, CHILD Study Investigators
DOI: 10.1503/cmaj.121189
PubMed: 23401405
03/2013

Distinct DNA methylation patterns of cognitive impairment and trisomy 21 in Down syndrome.
Jones MJ, Farré P, McEwen LM, Macisaac JL, Watt K, Neumann SM, Emberly E, Cynader MS, Virji-Babul N, Kobor MS
DOI: 10.1186/1755-8794-6-58
PubMed: 24373378
2013

DNA methylation, genotype and gene expression: who is driving and who is along for the ride?
Jones MJ, Fejes AP, Kobor MS
DOI: 10.1186/gb-2013-14-7-126
PubMed: 23899167
2013

The molecular mechanism of a cis-regulatory adaptation in yeast.
Chang J, Zhou Y, Hu X, Lam L, Henry C, Green EM, Kita R, Kobor MS, Fraser HB
DOI: 10.1371/journal.pgen.1003813
PubMed: 24068973
2013

Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence.
Essex MJ, Boyce WT, Hertzman C, Lam LL, Armstrong JM, Neumann SM, Kobor MS
DOI: 10.1111/j.1467-8624.2011.01641.x
PubMed: 21883162
2013

Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array.
Price ME, Cotton AM, Lam LL, Farré P, Emberly E, Brown CJ, Robinson WP, Kobor MS
DOI: 10.1186/1756-8935-6-4
PubMed: 23452981
2013

Histone H3K4 demethylation is negatively regulated by histone H3 acetylation in Saccharomyces cerevisiae.
Maltby VE, Martin BJ, Brind'Amour J, Chruscicki AT, McBurney KL, Schulze JM, Johnson IJ, Hills M, Hentrich T, Kobor MS, Lorincz MC, Howe LJ
DOI: 10.1073/pnas.1202070109
PubMed: 23091032
11/2012

Factors underlying variable DNA methylation in a human community cohort.
Lam LL, Emberly E, Fraser HB, Neumann SM, Chen E, Miller GE, Kobor MS
DOI: 10.1073/pnas.1121249109
PubMed: 23045638
10/2012

Histone H3 lysine 36 methylation targets the Isw1b remodeling complex to chromatin.
Maltby VE, Martin BJ, Schulze JM, Johnson I, Hentrich T, Sharma A, Kobor MS, Howe L
DOI: 10.1128/MCB.00389-12
PubMed: 22751925
09/2012

p300/CBP-associated factor selectively regulates the extinction of conditioned fear.
Wei W, Coelho CM, Li X, Marek R, Yan S, Anderson S, Meyers D, Mukherjee C, Sbardella G, Castellano S, Milite C, Rotili D, Mai A, Cole PA, Sah P, Kobor MS, Bredy TW
DOI: 10.1523/JNEUROSCI.0178-12.2012
PubMed: 22933779
08/2012

Different measures of "genome-wide" DNA methylation exhibit unique properties in placental and somatic tissues.
Price EM, Cotton AM, Peñaherrera MS, McFadden DE, Kobor MS, Robinson W
DOI: 10.4161/epi.20221
PubMed: 22531475
06/2012

CHROMATRA: a Galaxy tool for visualizing genome-wide chromatin signatures.
Hentrich T, Schulze JM, Emberly E, Kobor MS
DOI: 10.1093/bioinformatics/bts007
PubMed: 22238257
03/2012

19p13.2 microduplication causes a Sotos syndrome-like phenotype and alters gene expression.
Lehman AM, du Souich C, Chai D, Eydoux P, Huang JL, Fok AK, Avila L, Swingland J, Delaney AD, McGillivray B, Goldowitz D, Argiropoulos B, Kobor MS, Boerkoel CF
DOI: 10.1111/j.1399-0004.2010.01615.x
PubMed: 21204797
01/2012

R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants.
Stirling PC, Chan YA, Minaker SW, Aristizabal MJ, Barrett I, Sipahimalani P, Kobor MS, Hieter P
DOI: 10.1101/gad.179721.111
PubMed: 22279048
01/2012

DNA methylation profiles of airway epithelial cells and PBMCs from healthy, atopic and asthmatic children.
Stefanowicz D, Hackett TL, Garmaroudi FS, Günther OP, Neumann S, Sutanto EN, Ling KM, Kobor MS, Kicic A, Stick SM, Paré PD, Knight DA
DOI: 10.1371/journal.pone.0044213
PubMed: 22970180
2012

Population-specificity of human DNA methylation.
Fraser HB, Lam LL, Neumann SM, Kobor MS
DOI: 10.1186/gb-2012-13-2-r8
PubMed: 22322129
2012

Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123.
Schulze JM, Hentrich T, Nakanishi S, Gupta A, Emberly E, Shilatifard A, Kobor MS
DOI: 10.1101/gad.177220.111
PubMed: 22056669
11/2011

Key functional regions in the histone variant H2A.Z C-terminal docking domain.
Wang AY, Aristizabal MJ, Ryan C, Krogan NJ, Kobor MS
DOI: 10.1128/MCB.05182-11
PubMed: 21791612
09/2011

The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory.
Lin Q, Wei W, Coelho CM, Li X, Baker-Andresen D, Dudley K, Ratnu VS, Boskovic Z, Kobor MS, Sun YE, Bredy TW
DOI: 10.1038/nn.2891
PubMed: 21841775
09/2011

Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation.
Cotton AM, Lam L, Affleck JG, Wilson IM, Peñaherrera MS, McFadden DE, Kobor MS, Lam WL, Robinson WP, Brown CJ
DOI: 10.1007/s00439-011-1007-8
PubMed: 21597963
08/2011

Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks.
Leung GP, Lee L, Schmidt TI, Shirahige K, Kobor MS
DOI: 10.1074/jbc.M111.235200
PubMed: 21642432
07/2011

Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood.
Chen E, Miller GE, Kobor MS, Cole SW
DOI: 10.1038/mp.2010.53
PubMed: 20479762
07/2011

Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders.
Dudley KJ, Li X, Kobor MS, Kippin TE, Bredy TW
DOI: 10.1016/j.neubiorev.2010.12.016
PubMed: 21251925
06/2011

The specificity and topology of chromatin interaction pathways in yeast.
Lenstra TL, Benschop JJ, Kim T, Schulze JM, Brabers NA, Margaritis T, van de Pasch LA, van Heesch SA, Brok MO, Groot Koerkamp MJ, Ko CW, van Leenen D, Sameith K, van Hooff SR, Lijnzaad P, Kemmeren P, Hentrich T, Kobor MS, Buratowski S, Holstege FC
DOI: 10.1016/j.molcel.2011.03.026
PubMed: 21596317
05/2011

Dot1 and histone H3K79 methylation in natural telomeric and HM silencing.
Takahashi YH, Schulze JM, Jackson J, Hentrich T, Seidel C, Jaspersen SL, Kobor MS, Shilatifard A
DOI: 10.1016/j.molcel.2011.03.006
PubMed: 21474073
04/2011

Fetal alcohol spectrum disorders: gene-environment interactions, predictive biomarkers, and the relationship between structural alterations in the brain and functional outcomes.
Reynolds JN, Weinberg J, Clarren S, Beaulieu C, Rasmussen C, Kobor M, Dube MP, Goldowitz D
DOI: 10.1016/j.spen.2011.02.006
PubMed: 21575841
03/2011

Focus on: epigenetics and fetal alcohol spectrum disorders.
Kobor MS, Weinberg J
PubMed: 23580038
2011

Extensive epigenetic reprogramming in human somatic tissues between fetus and adult.
Yuen RK, Neumann SM, Fok AK, Peñaherrera MS, McFadden DE, Robinson WP, Kobor MS
DOI: 10.1186/1756-8935-4-7
PubMed: 21545704
2011

Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway.
Lévesque N, Leung GP, Fok AK, Schmidt TI, Kobor MS
DOI: 10.1074/jbc.M110.116855
PubMed: 20810656
11/2010

Reading chromatin: insights from yeast into YEATS domain structure and function.
Schulze JM, Wang AY, Kobor MS
DOI: 10.4161/epi.5.7.12856
PubMed: 20657183
10/2010

Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium.
Kicic A, Hallstrand TS, Sutanto EN, Stevens PT, Kobor MS, Taplin C, Paré PD, Beyer RP, Stick SM, Knight DA
DOI: 10.1164/rccm.200907-1071OC
PubMed: 20110557
05/2010

How the epigenome contributes to the development of psychiatric disorders.
Bredy TW, Sun YE, Kobor MS
DOI: 10.1002/dev.20424
PubMed: 20127889
05/2010

Roles for H2A.Z and its acetylation in GAL1 transcription and gene induction, but not GAL1-transcriptional memory.
Halley JE, Kaplan T, Wang AY, Kobor MS, Rine J
DOI: 10.1371/journal.pbio.1000401
PubMed: 20582323
2010

Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation.
Wang AY, Schulze JM, Skordalakes E, Gin JW, Berger JM, Rine J, Kobor MS
DOI: 10.1073/pnas.0906539106
PubMed: 19966225
12/2009

NuA4 and SWR1-C: two chromatin-modifying complexes with overlapping functions and components.
Lu PY, Lévesque N, Kobor MS
DOI: 10.1139/O09-062
PubMed: 19898529
10/2009

Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation.
Schulze JM, Jackson J, Nakanishi S, Gardner JM, Hentrich T, Haug J, Johnston M, Jaspersen SL, Kobor MS, Shilatifard A
DOI: 10.1016/j.molcel.2009.07.017
PubMed: 19682934
09/2009

Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling.
Miller GE, Chen E, Fok AK, Walker H, Lim A, Nicholls EF, Cole S, Kobor MS
DOI: 10.1073/pnas.0902971106
PubMed: 19617551
08/2009

H2A.Z and DNA methylation: irreconcilable differences.
Kobor MS, Lorincz MC
DOI: 10.1016/j.tibs.2008.12.006
PubMed: 19282182
04/2009

YEATS domain proteins: a diverse family with many links to chromatin modification and transcription.
Schulze JM, Wang AY, Kobor MS
DOI: 10.1139/O08-111
PubMed: 19234524
02/2009

Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes.
Yuen RK, Avila L, Peñaherrera MS, von Dadelszen P, Lefebvre L, Kobor MS, Robinson WP
DOI: 10.1371/journal.pone.0007389
PubMed: 19838307
2009

Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4.
Roberts TM, Kobor MS, Bastin-Shanower SA, Ii M, Horte SA, Gin JW, Emili A, Rine J, Brill SJ, Brown GW
DOI: 10.1091/mbc.E05-08-0785
PubMed: 16267268
01/2006

NMR structure of the amino-terminal domain from the Tfb1 subunit of TFIIH and characterization of its phosphoinositide and VP16 binding sites.
Di Lello P, Nguyen BD, Jones TN, Potempa K, Kobor MS, Legault P, Omichinski JG
DOI: 10.1021/bi050099s
PubMed: 15909982
05/2005

Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator.
Kong SE, Kobor MS, Krogan NJ, Somesh BP, Søgaard TM, Greenblatt JF, Svejstrup JQ
DOI: 10.1074/jbc.M411071200
PubMed: 15563457
02/2005

Dephosphorylation of RNA polymerase I by Fcp1p is required for efficient rRNA synthesis.
Fath S, Kobor MS, Philippi A, Greenblatt J, Tschochner H
DOI: 10.1074/jbc.M401867200
PubMed: 15073185
06/2004

A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin.
Kobor MS, Venkatasubrahmanyam S, Meneghini MD, Gin JW, Jennings JL, Link AJ, Madhani HD, Rine J
DOI: 10.1371/journal.pbio.0020131
PubMed: 15045029
05/2004

NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1.
Nguyen BD, Abbott KL, Potempa K, Kobor MS, Archambault J, Greenblatt J, Legault P, Omichinski JG
DOI: 10.1073/pnas.1031524100
PubMed: 12732728
05/2003

Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB.
Nguyen BD, Chen HT, Kobor MS, Greenblatt J, Legault P, Omichinski JG
DOI: 10.1021/bi0265473
PubMed: 12578358
02/2003

Purification and assay of Saccharomyces cerevisiae phosphatase that acts on the C-terminal domain of the largest subunit of RNA polymerase II.
Hoheisel S, Kobor MS, Pierstorff E, Greenblatt J, Kane CM
DOI: 10.1016/S0076-6879(03)70034-2
PubMed: 14712662
2003

RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach.
Krogan NJ, Kim M, Ahn SH, Zhong G, Kobor MS, Cagney G, Emili A, Shilatifard A, Buratowski S, Greenblatt JF
DOI: 10.1128/MCB.22.20.6979-6992.2002
PubMed: 12242279
10/2002

Regulation of transcription elongation by phosphorylation.
Kobor MS, Greenblatt J
DOI: 10.1016/S0167-4781(02)00457-8
PubMed: 12213657
09/2002

Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain.
Cho EJ, Kobor MS, Kim M, Greenblatt J, Buratowski S
DOI: 10.1101/gad.935901
PubMed: 11751637
12/2001

A motif shared by TFIIF and TFIIB mediates their interaction with the RNA polymerase II carboxy-terminal domain phosphatase Fcp1p in Saccharomyces cerevisiae.
Kobor MS, Simon LD, Omichinski J, Zhong G, Archambault J, Greenblatt J
DOI: 10.1128/MCB.20.20.7438-7449.2000
PubMed: 11003641
10/2000

An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.
Kobor MS, Archambault J, Lester W, Holstege FC, Gileadi O, Jansma DB, Jennings EG, Kouyoumdjian F, Davidson AR, Young RA, Greenblatt J
DOI: 10.1016/S1097-2765(00)80187-2
PubMed: 10445027
07/1999

GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8.
Hirst M, Kobor MS, Kuriakose N, Greenblatt J, Sadowski I
DOI: 10.1016/S1097-2765(00)80360-3
PubMed: 10360183
05/1999

An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae.
Archambault J, Chambers RS, Kobor MS, Ho Y, Cartier M, Bolotin D, Andrews B, Kane CM, Greenblatt J
DOI: 10.1073/pnas.94.26.14300
PubMed: 9405607
12/1997

Identification of a nucleic acid-binding region within the largest subunit of Drosophila melanogaster RNA polymerase II.
Kontermann RE, Kobor M, Bautz EK
DOI: 10.1002/pro.5560020211
PubMed: 8443600
02/1993

Research

Current project
In one facet of our research program, we study human population epigenetics aimed at deciphering the mechanisms by which environmental exposures and early-life experiences can "get under the skin" to regulate gene activity and contribute to health and disease across the life course. This research aligns with the Developmental Origins of Health and Disease (DOHaD) hypothesis, which postulates that the developmental period and early life are particularly sensitive periods where social or environmental insults can influence health long after the insult itself. Our findings support the model that early-life social and environmental factors, including stress and socioeconomic status, leave a biological footprint. We measure this biological embedding of early life exposures through epigenetic patterns and accompanying gene expression changes, many of which are maintained until adulthood and may influence future health. We have extensive interdisciplinary collaborations across Canada and around the world and are affiliated with multiple NCEs (including AllerGen and NeuroDevNet).

Rather than acting as an inert scaffold for DNA, dynamic and flexible chromatin structures and modifications have profound effects on almost all aspects of chromosome behaviour and genome function. Thus, the second objective of our research utilizes Saccharomyces cerevisiae as a model organism to tease apart the mechanisms responsible for the creation, regulation, and maintenance of the chromatin signature. These queries include how distinct chromosomal neighbourhoods are established, how they function and interact with enzymes involved in DNA metabolism, what functional differences exist between histone variants and canonical histones, and how chromatin-remodeling complexes are regulated. Currently, we focus on three distinct areas of chromatin biology: functional genomic characterization of chromatin-modifying complexes; DNA damage repair in the context of the chromatin template; and crosstalk between the RNAPII machinery and chromatin.

Together, the research in our lab bridges the molecular mechanisms of epigenetic regulation with the social and environmental determinants of human health to develop a comprehensive understanding of early life.

Honours & Awards

Award of Excellence, Biomedical Research, CFRI Member Recognition Awards, 2013

Canada Research Chair Tier 1 in Social Epigenetics, 2014-present

Senior Fellow, Canadian Institute for Advanced Research, Child & Brain Development program, 2013-present

Research Group Members

Maria Aristizabal, Postdoctoral Fellow
Tanya Erb
Sachini Ariyaratne, Masters Student
Lisa McEwen
Alyssa Kirlin
Nadia Jajja
Sarah Goodman
Julie MacIsaac, Research Associate/Lab manager
Nicole Gladish
Meaghan Jones
Sumaiya Islam
Joshua Brown
Evan Gatev
Alexander Morin
Rachel Edgar
Olivia Wong
Kristy Dever
Samantha Schaffner, Graduate Research Assistant
Sarah Moore
Hilary Brewis
David Lin, PhD Research Associate
Mara Thomas
Joe Dong
Tiffany Reeve, Healthy Starts Research Coordinator
Maggie Fu, Graduate Student
Michael Doyle
Anson Law, Undergraduate Student
Nivretta Thatra, Graduate Student
Chloe You
Helena Biasibetti Brendler
Calvin Wong, Undergraduate Student