My research focuses on improvement of transfusion medicine practices, particularly as they apply to pediatric patients.
Monolobated megakaryocytes in Diamond–Blackfan anemia with RPL5 mutation at disease presentation mimicking myelodysplastic syndrome
Pediatric Blood and Cancer
DOI: 10.1002/pbc.30771
2024
Evaluation of Low-Cost Techniques to Detect Sickle Cell Disease and ¿-Thalassemia: An International Multi-Center Study
SSRN
2024
Clinical and laboratory features associated with myeloperoxidase expression in pediatric B-lymphoblastic leukemia
Cytometry Part B: Clinical Cytometry
Eric McGinnis and David Yang and Nicholas Au and Douglas Morrison and Kate M. Chipperfield and Audi F. Setiadi and Lorraine Liu and Angela Tsang and Suzanne M. Vercauteren
DOI: 10.1002/cyto.b.21966
10/2020
Feasibility of manual white blood cell counts as a predictor of neonatal sepsis in a low-resource setting
Transactions of The Royal Society of Tropical Medicine and Hygiene
Christian N Golding and Frederik Schaltz-Buchholzer and Lilica Sanca and Clara Clipet-Jensen and Christine S Benn and Nicholas Au and Kate Chipperfield and Tobias R Kollmann and Nelly A Amenyogbe
DOI: 10.1093/trstmh/traa023
04/2020
Inter-hospital variation in use of obstetrical blood transfusion: a population-based cohort study
BJOG: An International Journal of Obstetrics and Gynaecology
Hutcheon, J.A. and Chapinal, N. and Skoll, A. and Au, N. and Lee, L.
DOI: 10.1111/1471-0528.16203
2020
Accuracy of Blood Transfusion Records in a Population-based Perinatal Data Registry
Epidemiology
Hutcheon, J.A. and Chapinal, N. and Skoll, M.A. and Au, N. and Lee, L.
DOI: 10.1097/EDE.0000000000001183
2020
Severe hemolytic disease of the fetus and newborn due to allo-anti-D in a patient with a partial DEL phenotype arising from the variant allele described as RHD*148+1T (RHD*01EL.31)
Transfusion
Turley, E. and McGowan, E.C. and Hyland, C.A. and Schoeman, E.M. and Flower, R.L. and Skoll, A. and Delisle, M.-F. and Nelson, T. and Clarke, G. and Au, N.
DOI: 10.1111/trf.14944
2018
JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome
Journal of Allergy and Clinical Immunology
Del Bel, K.L. and Ragotte, R.J. and Saferali, A. and Lee, S. and Vercauteren, S.M. and Mostafavi, S.A. and Schreiber, R.A. and Prendiville, J.S. and Phang, M.S. and Halparin, J. and Au, N. and Dean, J.M. and Priatel, J.J. and Jewels, E. and Junker, A.K. and Rogers, P.C. and Seear, M. and McKinnon, M.L. and Turvey, S.E.
DOI: 10.1016/j.jaci.2016.12.957
2017
Impact of preoperative laboratory investigation and blood cross-match on clinical management of pediatric neurosurgical patients
Child's Nervous System
Yang, M.M.H. and Singhal, A. and Au, N. and Hengel, A.R.
DOI: 10.1007/s00381-015-2617-6
2015
Acute encephalopathy in a kidney transplant recipient following infusion of intravenous immunoglobulin
Transplant International
Wang, L. and Larkins, N. and Jung, B. and Au, N.H.C. and Mammen, C.
DOI: 10.1111/tri.12384
2014
Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking
Orphanet Journal of Rare Diseases
Stockler, S. and Corvera, S. and Lambright, D. and Fogarty, K. and Nosova, E. and Leonard, D. and Steinfeld, R. and Ackerley, C. and Shyr, C. and Au, N. and Selby, K. and Van Allen, M. and Vallance, H. and Wevers, R. and Watkins, D. and Rosenblatt, D. and Ross, C.J. and Conibear, E. and Wasserman, W. and Van Karnebeek, C.
DOI: 10.1186/s13023-014-0141-5
2014
Microdeletion of exon 3 in the HBA2 gene associated with mild a-thalassemia trait
Hemoglobin
Lambert, A. and Wong, A.Y.K. and Kominami, Y. and Smith, V.C. and Reddy, S. and Wadsworth, L.D. and Au, N.H.C. and MacGillivray, R.T.A.
DOI: 10.3109/03630269.2013.763257
2013
Blueberry muffin rash and thrombocytopenia in a newborn with mucolipidosis type II (I-cell disease) masquerading as congenital infections
Molecular Genetics and Metabolism
Ting, J. and Hochwald, O. and Au, N. and Mercimek-Mahmutoglu, S.
DOI: 10.1016/j.ymgme.2011.09.003
2011
Two new examples of Hb st. etienne [ß92(F8)His¿Gln] in association with venous thrombosis
Hemoglobin
Au, N.H.C. and Wong, A.Y.K. and Vickars, L. and MacGillivray, R.T.A. and Wadsworth, L.D.
DOI: 10.1080/03630260902817206
2009
Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: A tissue microarray study of 284 cases and 18 markers
Journal of Pathology
Au, N.H.C. and Cheang, M. and Huntsman, D.G. and Yorida, E. and Coldman, A. and Elliott, W.M. and Bebb, G. and Flint, J. and English, J. and Gilks, C.B. and Grimes, H.L.
DOI: 10.1002/path.1612
2004
Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells
Cancer Research
Kazanjian, A. and Wallis, D. and Au, N. and Nigam, R. and Venken, K.J.T. and Cagle, P.T. and Dickey, B.F. and Bellen, H.J. and Gilks, C.B. and Grimes, H.L.
DOI: 10.1158/0008-5472.CAN-04-0633
2004
P63 expression in lung carcinoma: a tissue microarray study of 408 cases.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry
Au, N.H. and Gown, A.M. and Cheang, M. and Huntsman, D. and Yorida, E. and Elliott, W.M. and Flint, J. and English, J. and Gilks, C.B. and Grimes, H.L.
DOI: 10.1097/00129039-200409000-00010
2004
Detection and Genotyping of Varicella-Zoster Virus by TaqMan Allelic Discrimination Real-Time PCR
Journal of Clinical Microbiology
Campsall, P.A. and Au, N.H.C. and Prendiville, J.S. and Speert, D.P. and Tan, R. and Thomas, E.E.
DOI: 10.1128/JCM.42.4.1409-1413.2004
2004
Current Projects
Neonatal alloimmune thrombocytopenia (NAIT) is a blood disease in newborns which develops when the pregnant mother produces antibodies that destroy the newborns' platelets. According to current guidelines, NAIT should be treated by transfusing a certain type of platelets (HPA-1a negative platelets). However, the availability of HPA-1a negative platelets is limited. I am currently conducting a study to determine if transfusion with random donor platelets is effective in treating NAIT.
Red blood cells are frequently transfused in acute care institutions for the management of anemia, however research has shown that approximately 30% of red cell transfusions may be inappropriate. Red blood cells are derived from voluntary human donors and represent a precious medical resource. Transfusions also carry risks to the recipient, some of which may lead to morbidity and even mortality. I am participating in a quality study to assess the appropriateness of medical red cell transfusions.
A pan-Canadian team has developed a new way to quickly find personalized treatments for young cancer patients, by growing their tumours in chicken eggs and analyzing their proteins.
The team, led by researchers from BC Children’s Hospital Research Institute and the University of British Columbia, is the first in Canada to combine these two techniques to identify and test a drug for a young patient's tumour in time for their treatment.
We believe there’s nothing we can’t do with your support. It can take years to turn scientific breakthrough into new interventions and treatments. Funding helps speed the pace of change. When given the resources, we can bring transformative therapies – and hope – out of the laboratory and into the clinic to save and improve children’s lives.