Overview

My research focuses on improvement of transfusion medicine practices, particularly as they apply to pediatric patients.

Publications

Clinical and laboratory features associated with myeloperoxidase expression in pediatric B-lymphoblastic leukemia
Cytometry Part B: Clinical Cytometry
Eric McGinnis and David Yang and Nicholas Au and Douglas Morrison and Kate M. Chipperfield and Audi F. Setiadi and Lorraine Liu and Angela Tsang and Suzanne M. Vercauteren
DOI: 10.1002/cyto.b.21966
10/2020

Feasibility of manual white blood cell counts as a predictor of neonatal sepsis in a low-resource setting
Transactions of The Royal Society of Tropical Medicine and Hygiene
Christian N Golding and Frederik Schaltz-Buchholzer and Lilica Sanca and Clara Clipet-Jensen and Christine S Benn and Nicholas Au and Kate Chipperfield and Tobias R Kollmann and Nelly A Amenyogbe
DOI: 10.1093/trstmh/traa023
04/2020

Inter-hospital variation in use of obstetrical blood transfusion: a population-based cohort study
BJOG: An International Journal of Obstetrics and Gynaecology
Hutcheon, J.A. and Chapinal, N. and Skoll, A. and Au, N. and Lee, L.
DOI: 10.1111/1471-0528.16203
2020

Accuracy of blood transfusion records in a population-based perinatal data registry
Epidemiology
Hutcheon, J.A. and Chapinal, N. and Amanda Skoll, M. and Au, N. and Lee, L.
DOI: 10.1097/EDE.0000000000001183
2020

Severe hemolytic disease of the fetus and newborn due to allo-anti-D in a patient with a partial DEL phenotype arising from the variant allele described as RHD*148+1T (RHD*01EL.31)
Transfusion
Elona Turley and Eunike C. McGowan and Catherine A. Hyland and Elizna M. Schoeman and Robert L. Flower and Amanda Skoll and Marie-France Delisle and Tanya Nelson and Gwen Clarke and Nicholas Au
DOI: 10.1111/trf.14944
09/2018

JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome
Journal of Allergy and Clinical Immunology
Kate L. Del Bel and Robert J. Ragotte and Aabida Saferali and Susan Lee and Suzanne M. Vercauteren and Sara A. Mostafavi and Richard A. Schreiber and Julie S. Prendiville and Min S. Phang and Jessica Halparin and Nicholas Au and John M. Dean and John J. Priatel and Emily Jewels and Anne K. Junker and Paul C. Rogers and Michael Seear and Margaret L. McKinnon and Stuart E. Turvey
DOI: 10.1016/j.jaci.2016.12.957
06/2017

Impact of preoperative laboratory investigation and blood cross-match on clinical management of pediatric neurosurgical patients
Child's Nervous System
Michael M. H. Yang and Ash Singhal and Nicholas Au and A. Ross Hengel
DOI: 10.1007/s00381-015-2617-6
02/2015

Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking
Orphanet Journal of Rare Diseases
Sylvia Stockler and Silvia Corvera and David Lambright and Kevin Fogarty and Ekaterina Nosova and Deborah Leonard and Robert Steinfeld and Cameron Ackerley and Casper Shyr and Nicolas Au and Kathrin Selby and Margot van Allen and Hilary Vallance and Ron Wevers and David Watkins and David Rosenblatt and Colin J Ross and Elizabeth Conibear and Wyeth Wasserman and Clara van Karnebeek
DOI: 10.1186/s13023-014-0141-5
09/2014

Acute encephalopathy in a kidney transplant recipient following infusion of intravenous immunoglobulin
Transplant International
Li Wang and Nicholas Larkins and Benjamin Jung and Nicholas H.C. Au and Cherry Mammen
DOI: 10.1111/tri.12384
08/2014

Microdeletion Of Exon 3 In The HBA2 Gene Associated With Milda-Thalassemia Trait
Hemoglobin
Anne Lambert and Ann Y.K. Wong and Yohji Kominami and Valerie C. Smith and Suseela Reddy and Louis D. Wadsworth and Nicholas H.C. Au and Ross T.A. MacGillivray
DOI: 10.3109/03630269.2013.763257
01/2013

Blueberry muffin rash and thrombocytopenia in a newborn with mucolipidosis type II (I-cell disease) masquerading as congenital infections
Molecular Genetics and Metabolism
Joseph Ting and Ori Hochwald and Nicholas Au and Saadet Mercimek-Mahmutoglu
DOI: 10.1016/j.ymgme.2011.09.003
2011

Two New Examples of Hb St. Etienne [ß 92(F8)His¿Gln] in Association with Venous Thrombosis
Hemoglobin
Nicholas H.C. Au and Ann Y.K. Wong and Linda Vickars and Ross T.A. MacGillivray and Louis D. Wadsworth
DOI: 10.1080/03630260902817206
01/2009

Growth Factor Independence-1 Is Expressed in Primary Human Neuroendocrine Lung Carcinomas and Mediates the Differentiation of Murine Pulmonary Neuroendocrine Cells
Cancer Research
Avedis Kazanjian and Deeann Wallis and Nicholas Au and Rupesh Nigam and Koen J. T. Venken and Philip T. Cagle and Burton F. Dickey and Hugo J. Bellen and C. Blake Gilks and H. Leighton Grimes
DOI: 10.1158/0008-5472.can-04-0633
10/2004

p63 Expression in Lung Carcinoma
Applied Immunohistochemistry & Molecular Morphology
N. H. C. Au and A. M. Gown and M. Cheang and D. Huntsman and E. Yorida and W. M. Elliott and J. Flint and J. English and C. B. Gilks and H. L. Grimes
DOI: 10.1097/00129039-200409000-00010
09/2004

Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers
The Journal of Pathology
NHC Au and M Cheang and DG Huntsman and E Yorida and A Coldman and WM Elliott and G Bebb and J Flint and J English and CB Gilks and HL Grimes
DOI: 10.1002/path.1612
08/2004

Detection and Genotyping of Varicella-Zoster Virus by TaqMan Allelic Discrimination Real-Time PCR
Journal of Clinical Microbiology
P. A. Campsall and N. H. C. Au and J. S. Prendiville and D. P. Speert and R. Tan and E. E. Thomas
DOI: 10.1128/jcm.42.4.1409-1413.2004
04/2004

Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells
Cancer Research
Kazanjian, A. and Wallis, D. and Au, N. and Nigam, R. and Venken, K.J.T. and Cagle, P.T. and Dickey, B.F. and Bellen, H.J. and Gilks, C.B. and Grimes, H.L.
DOI: 10.1158/0008-5472.CAN-04-0633
2004

Detection and Genotyping of Varicella-Zoster Virus by TaqMan Allelic Discrimination Real-Time PCR
Journal of Clinical Microbiology
Campsall, P.A. and Au, N.H.C. and Prendiville, J.S. and Speert, D.P. and Tan, R. and Thomas, E.E.
DOI: 10.1128/JCM.42.4.1409-1413.2004
2004

Research

Current Projects
Neonatal alloimmune thrombocytopenia (NAIT) is a blood disease in newborns which develops when the pregnant mother produces antibodies that destroy the newborns' platelets. According to current guidelines, NAIT should be treated by transfusing a certain type of platelets (HPA-1a negative platelets). However, the availability of HPA-1a negative platelets is limited. I am currently conducting a study to determine if transfusion with random donor platelets is effective in treating NAIT.

Red blood cells are frequently transfused in acute care institutions for the management of anemia, however research has shown that approximately 30% of red cell transfusions may be inappropriate. Red blood cells are derived from voluntary human donors and represent a precious medical resource. Transfusions also carry risks to the recipient, some of which may lead to morbidity and even mortality. I am participating in a quality study to assess the appropriateness of medical red cell transfusions.