Publications

Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus
Clinical Epigenetics
DOI: 10.1186/s13148-019-0682-5
12/2019

Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness
Psychoneuroendocrinology
DOI: 10.1016/j.psyneuen.2019.01.013
05/2019

A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment
Journal of the American Academy of Child & Adolescent Psychiatry
DOI: 10.1016/j.jaac.2019.03.006
03/2019

DRD4 methylation as a potential biomarker for physical aggression: An epigenome-wide, cross-tissue investigation
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
DOI: 10.1002/ajmg.b.32689
12/2018

HAM-TBS: high-accuracy methylation measurements via targeted bisulfite sequencing
Epigenetics & Chromatin
DOI: 10.1186/s13072-018-0209-x
12/2018

From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health
Progress in Molecular Biology and Translational Science
DOI: 10.1016/bs.pmbts.2018.04.011
2018

Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: A prospective longitudinal study
Development and Psychopathology
Madeline B. Harms and Rasmus Birn and Nadine Provencal and Tobias Wiechmann and Elisabeth B. Binder and Sebastian W. Giakas and Barbara J. Roeber and Seth D. Pollak
DOI: 10.1017/s095457941700147x
11/2017

Epigenetic effects of glucocorticoids exposure during hippocampal neurogenesis and their implication in psychiatric disorders
European Neuropsychopharmacology
N. Provençal and J. Arloth and A. Cattaneo and C. Anacker and T. Klengel and C. Pariante and E. Binder
DOI: 10.1016/s0924-977x(17)31059-3
10/2017

Dynamic DNA methylation changes in the oxytocin locus (OXT) during pregnancy are associated with maternal parenting behavior
Psychoneuroendocrinology
Philipp Toepfer and Kieran J. ÓDonnell and Christine M. Heim and David T.S. Lin and Julia L. MacIsaac and Michael S. Kobor and Michael J. Meaney and Nadine Provencal and Elisabeth B. Binder and Sonja Entringer and Pathik D. Wadhwa and Claudia Buss
DOI: 10.1016/j.psyneuen.2017.07.306
09/2017

HAM-TBS: High accuracy methylation measurements via targeted bisulfite sequencing
Simone Roeh and Nadine Provencal and Tobias Wiechmann and Maik Koedel and Susann Sauer and Elisabeth B. Binder
DOI: 10.1101/163535
07/2017

How Can GxE Research Help Prevent the Development of Chronic Physical Aggression?
Gene-Environment Transactions in Developmental Psychopathology
Richard E. Tremblay and Linda Booij and Nadine Provençal and Moshe Szyf
DOI: 10.1007/978-3-319-49227-8_10
2017

A variation in the oxytocin receptor gene moderates the relationship between early maternal care in childhood and interleukin 6 (IL-6) concentrations during pregnancy
Psychoneuroendocrinology
Philipp Toepfer and Christine M. Heim and Sonja Entringer and Pathik D. Wadhwa and Nadine Provencal and Elisabeth B. Binder and Claudia Buss
DOI: 10.1016/j.psyneuen.2016.07.049
09/2016

Epigenetic mechanisms involved in the effects of stress exposure: focus on 5-hydroxymethylcytosine: Table 1:
Environmental Epigenetics
Laura M. Hack and Alec L.W. Dick and Nadine Provençal
DOI: 10.1093/eep/dvw016
08/2016

Alterations in DNA Methylation and Hydroxymethylation Due to Parental Care in Rhesus Macaques
Epigenetics and Neuroendocrinology
Nadine Provencal and Renaud Massart and Zsofia Nemoda and Stephen Suomi
DOI: 10.1007/978-3-319-24493-8_7
2016

The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development, and Chronic Physical Aggression: Prospects for Early Protective Interventions
Translational Toxicology
DOI: 10.1007/978-3-319-27449-2_10
2016

Dynamic Changes in DNA Methylation Occur during the First Year of Life in Preterm Infants
Frontiers in Endocrinology
Chinthika Piyasena and Jessy Cartier and Nadine Provençal and Tobias Wiechmann and Batbayar Khulan and Raju Sunderesan and Gopi Menon and Jonathan R. Seckl and Rebecca M. Reynolds and Elisabeth B. Binder and Amanda J. Drake
DOI: 10.3389/fendo.2016.00158
2016

Impact of Early Environment on Children's Mental Health: Lessons From DNA Methylation Studies With Monozygotic Twins
Twin Research and Human Genetics
Julian Chiarella and Richard E. Tremblay and Moshe Szyf and Nadine Provençal and Linda Booij
DOI: 10.1017/thg.2015.84
11/2015

Epigenetics of Posttraumatic Stress Disorder: Current Evidence, Challenges, and Future Directions
Biological Psychiatry
Anthony S. Zannas and Nadine Provençal and Elisabeth B. Binder
DOI: 10.1016/j.biopsych.2015.04.003
09/2015

The effects of early life stress on the epigenome: From the womb to adulthood and even before
Experimental Neurology
Nadine Provençal and Elisabeth B. Binder
DOI: 10.1016/j.expneurol.2014.09.001
06/2015

The neurobiological effects of stress as contributors to psychiatric disorders: focus on epigenetics
Current Opinion in Neurobiology
Nadine Provencal and Elisabeth B Binder
DOI: 10.1016/j.conb.2014.08.007
02/2015

The developmental origins of chronic physical aggression: biological pathways triggered by early life adversity
Journal of Experimental Biology
N. Provencal and L. Booij and R. E. Tremblay
DOI: 10.1242/jeb.111401
01/2015

Hydroxymethylation and DNA methylation profiles in the prefrontal cortex of the non-human primate rhesus macaque and the impact of maternal deprivation on hydroxymethylation
Neuroscience
R. Massart and M. Suderman and N. Provencal and C. Yi and A.J. Bennett and S. Suomi and M. Szyf
DOI: 10.1016/j.neuroscience.2014.03.021
05/2014

Association of Childhood Chronic Physical Aggression with a DNA Methylation Signature in Adult Human T Cells
PLoS ONE
Nadine Provençal and Matthew J. Suderman and Claire Guillemin and Frank Vitaro and Sylvana M. Côté and Michael Hallett and Richard E. Tremblay and Moshe Szyf
DOI: 10.1371/journal.pone.0089839
04/2014

DNA Methylation Signature of Childhood Chronic Physical Aggression in T Cells of Both Men and Women
PLoS ONE
Claire Guillemin and Nadine Provençal and Matthew Suderman and Sylvana M. Côté and Frank Vitaro and Michael Hallett and Richard E. Tremblay and Moshe Szyf
DOI: 10.1371/journal.pone.0086822
01/2014

Epigenetics in Posttraumatic Stress Disorder
Epigenetics and Neuroplasticity—Evidence and Debate
Carina Rampp and Elisabeth B. Binder and Nadine Provençal
DOI: 10.1016/b978-0-12-800977-2.00002-4
2014

Differential DNA Methylation Regions in Cytokine and Transcription Factor Genomic Loci Associate with Childhood Physical Aggression
PLoS ONE
Nadine Provençal and Matthew J. Suderman and Doretta Caramaschi and Dongsha Wang and Michael Hallett and Frank Vitaro and Richard E. Tremblay and Moshe Szyf
DOI: 10.1371/journal.pone.0071691
08/2013

Childhood Chronic Physical Aggression Associates with Adult Cytokine Levels in Plasma
PLoS ONE
Nadine Provençal and Matthew J. Suderman and Frank Vitaro and Moshe Szyf and Richard E. Tremblay
DOI: 10.1371/journal.pone.0069481
07/2013

The Signature of Maternal Rearing in the Methylome in Rhesus Macaque Prefrontal Cortex and T Cells
Journal of Neuroscience
N. Provencal and M. J. Suderman and C. Guillemin and R. Massart and A. Ruggiero and D. Wang and A. J. Bennett and P. J. Pierre and D. P. Friedman and S. M. Cote and M. Hallett and R. E. Tremblay and S. J. Suomi and M. Szyf
DOI: 10.1523/jneurosci.1470-12.2012
10/2012

Peripheral SLC6A4 DNA Methylation Is Associated with In Vivo Measures of Human Brain Serotonin Synthesis and Childhood Physical Aggression
PLoS ONE
Dongsha Wang and Moshe Szyf and Chawki Benkelfat and Nadine Provençal and Gustavo Turecki and Doretta Caramaschi and Sylvana M. Côté and Frank Vitaro and Richard E. Tremblay and Linda Booij
DOI: 10.1371/journal.pone.0039501
06/2012

HOW DOES EARLY LIFE SOCIAL ENVIRONMENT SCULPT OUR GENES?
Biology of Reproduction
Moshe Szyf and Ian C.G. Weaver and Nadine Provencal and Patrick McGowan and Gustavo Turecki and Richard Tremblay and Michael Meaney
DOI: 10.1093/biolreprod/77.s1.64
07/2007

Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines
Biochemical Pharmacology
Jing-Ni Ou and Jérôme Torrisani and Alexander Unterberger and Nadine Provençal and Keisuke Shikimi and Mohsen Karimi and Tomas J. Ekström and Moshe Szyf
DOI: 10.1016/j.bcp.2006.12.032
05/2007

Research
Grants

Bell Grant: Access to the Signature Biobank 2015-2016

Brain & Behavior Research Foundation: NARSAD Young Investigator Grant 2017-2019

Honours & Awards

Fellowship Award, Canadian Institute of Health Research (CIHR) 2015-2017

Richard Todd Award, International Society of Psychiatric Genetics 2014

Research Group Members

Andressa Coope dos Santos Botezelli, Research Associate / Laboratory Manager