- Publications
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Associations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples
Frontiers in Cell and Developmental Biology
Perret, L.C. and Geoffroy, M.-C. and Barr, E. and Parnet, F. and Provencal, N. and Boivin, M. and O?Donnell, K.J. and Suderman, M. and Power, C. and Turecki, G. and Ouellet-Morin, I.
DOI: 10.3389/fcell.2022.1051556
2023Association between child maltreatment and depressive symptoms in emerging adulthood: The mediating and moderating roles of DNA methylation
PLoS ONE
Comtois-Cabana, M. and Barr, E. and Proven?al, N. and Ouellet-Morin, I.
DOI: 10.1371/journal.pone.0280203
2023A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes
Biological Psychiatry
DOI: 10.1016/j.biopsych.2023.06.028
2023The Impact of School Social Experiences on Socioemotional and Behavioral Problems: The Hypothesized Role of DNA Methylation
Biosocial Interplay During Elementary School: Pathways Toward Maladaptation in Young Children
DOI: 10.1007/978-3-031-07109-6_5
2022Combined effects of genotype and childhood adversity shape variability of DNA methylation across age
Translational Psychiatry
Czamara, D. and Tissink, E. and Tuhkanen, J. and Martins, J. and Awaloff, Y. and Drake, A.J. and Khulan, B. and Palotie, A. and Winter, S.M. and Nemeroff, C.B. and Craighead, W.E. and Dunlop, B.W. and Mayberg, H.S. and Kinkead, B. and Mathew, S.J. and Iosifescu, D.V. and Neylan, T.C. and Heim, C.M. and Lahti, J. and Eriksson, J.G. and Räikkönen, K. and Ressler, K.J. and Proven?al, N. and Binder, E.B.
DOI: 10.1038/s41398-020-01147-z
2021A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders.
Neurobiology of stress
Suarez A and Lahti J and Lahti-Pulkkinen M and Girchenko P and Czamara D and Arloth J and Malmberg AL and Hämäläinen E and Kajantie E and Laivuori H and Villa PM and Reynolds RM and Räikkönen K
DOI: 10.1016/j.ynstr.2020.100275
PubMed: 33344728
11/2020Investigation of MORC1 DNA methylation as biomarker of early life stress and depressive symptoms
Journal of Psychiatric Research
Thomas, M. and Coope, A. and Falkenberg, C. and Dunlop, B.W. and Czamara, D. and Provencal, N. and Craighead, W.E. and Mayberg, H.S. and Nemeroff, C.B. and Binder, E.B. and Nieratschker, V.
DOI: 10.1016/j.jpsychires.2019.10.019
2020Intergenerational effects of maternal holocaust exposure on FKBP5 methylation
American Journal of Psychiatry
Bierer, L.M. and Bader, H.N. and Daskalakis, N.P. and Lehrner, A. and Proven?al, N. and Wiechmann, T. and Klengel, T. and Makotkine, I. and Binder, E.B. and Yehuda, R.
DOI: 10.1176/appi.ajp.2019.19060618
2020Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation.
Proceedings of the National Academy of Sciences of the United States of America
Provençal N and Arloth J and Cattaneo A and Anacker C and Cattane N and Wiechmann T and Röh S and Ködel M and Klengel T and Czamara D and Müller NS and Lahti J and PREDO team and Binder EB
DOI: 10.1073/pnas.1820842116
PubMed: 31399550
08/2019Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus
Clinical Epigenetics
Wiechmann, T. and Röh, S. and Sauer, S. and Czamara, D. and Arloth, J. and Ködel, M. and Beintner, M. and Knop, L. and Menke, A. and Binder, E.B. and Proven?al, N.
DOI: 10.1186/s13148-019-0682-5
2019Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness
Psychoneuroendocrinology
Toepfer, P. and O'Donnell, K.J. and Entringer, S. and Garg, E. and Heim, C.M. and Lin, D.T.S. and MacIsaac, J.L. and Kobor, M.S. and Meaney, M.J. and Proven?al, N. and Binder, E.B. and Wadhwa, P.D. and Buss, C.
DOI: 10.1016/j.psyneuen.2019.01.013
2019A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment
Journal of the American Academy of Child and Adolescent Psychiatry
Toepfer, P. and O'Donnell, K.J. and Entringer, S. and Heim, C.M. and Lin, D.T.S. and MacIsaac, J.L. and Kobor, M.S. and Meaney, M.J. and Proven?al, N. and Binder, E.B. and Wadhwa, P.D. and Buss, C.
DOI: 10.1016/j.jaac.2019.03.006
2019DRD4 methylation as a potential biomarker for physical aggression: An epigenome-wide, cross-tissue investigation
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Cecil, C.A.M. and Walton, E. and Pingault, J.-B. and Proven?al, N. and Pappa, I. and Vitaro, F. and Côté, S. and Szyf, M. and Tremblay, R.E. and Tiemeier, H. and Viding, E. and McCrory, E.J.
DOI: 10.1002/ajmg.b.32689
2018Corrigendum: Dynamic changes in DNA methylation occur during the first year of life in preterm infants [Front Endocrinol, 7, (2016) (158)] doi: 10.3389/fendo.2016.00158
Frontiers in Endocrinology
Piyasena, C. and Cartier, J. and Provencal, N. and Wiechmann, T. and Khulan, B. and Sunderesan, R. and Menon, G. and Seckl, J. and Reynolds, R.M. and Binder, E.B. and Drake, A.J.
DOI: 10.3389/fendo.2018.00047
2018HAM-TBS: High-accuracy methylation measurements via targeted bisulfite sequencing
Epigenetics and Chromatin
Roeh, S. and Wiechmann, T. and Sauer, S. and Ködel, M. and Binder, E.B. and Proven?al, N.
DOI: 10.1186/s13072-018-0209-x
2018Central Neuroepigenetic Regulation of the Hypothalamic–Pituitary–Adrenal Axis
Progress in Molecular Biology and Translational Science
DOI: 10.1016/bs.pmbts.2018.04.006
2018From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health
Progress in Molecular Biology and Translational Science
Renzi, C. and Provencal, N. and Bassil, K.C. and Evers, K. and Kihlbom, U. and Radford, E.J. and Koupil, I. and Mueller-Myhsok, B. and Hansson, M.G. and Rutten, B.P.F.
DOI: 10.1016/bs.pmbts.2018.04.011
2018Epigenetic effects of glucocorticoids exposure during hippocampal neurogenesis and their implication in psychiatric disorders
European Neuropsychopharmacology
N. Provençal and J. Arloth and A. Cattaneo and C. Anacker and T. Klengel and C. Pariante and E. Binder
DOI: 10.1016/s0924-977x(17)31059-3
10/2017Dynamic DNA methylation changes in the oxytocin locus (OXT) during pregnancy are associated with maternal parenting behavior
Psychoneuroendocrinology
Philipp Toepfer and Kieran J. ÓDonnell and Christine M. Heim and David T.S. Lin and Julia L. MacIsaac and Michael S. Kobor and Michael J. Meaney and Nadine Provencal and Elisabeth B. Binder and Sonja Entringer and Pathik D. Wadhwa and Claudia Buss
DOI: 10.1016/j.psyneuen.2017.07.306
09/2017HAM-TBS: High accuracy methylation measurements via targeted bisulfite sequencing
DOI: 10.1101/163535
07/2017How Can GxE Research Help Prevent the Development of Chronic Physical Aggression?
Gene-Environment Transactions in Developmental Psychopathology
DOI: 10.1007/978-3-319-49227-8_10
2017Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: A prospective longitudinal study
Development and Psychopathology
Harms, M.B. and Birn, R. and Provencal, N. and Wiechmann, T. and Binder, E.B. and Giakas, S.W. and Roeber, B.J. and Pollak, S.D.
DOI: 10.1017/S095457941700147X
2017A variation in the oxytocin receptor gene moderates the relationship between early maternal care in childhood and interleukin 6 (IL-6) concentrations during pregnancy
Psychoneuroendocrinology
Philipp Toepfer and Christine M. Heim and Sonja Entringer and Pathik D. Wadhwa and Nadine Provencal and Elisabeth B. Binder and Claudia Buss
DOI: 10.1016/j.psyneuen.2016.07.049
09/2016Epigenetic mechanisms involved in the effects of stress exposure: focus on 5-hydroxymethylcytosine: Table 1:
Environmental Epigenetics
Laura M. Hack and Alec L.W. Dick and Nadine Provençal
DOI: 10.1093/eep/dvw016
08/2016Alterations in DNA Methylation and Hydroxymethylation Due to Parental Care in Rhesus Macaques
Epigenetics and Neuroendocrinology
DOI: 10.1007/978-3-319-24493-8_7
2016The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development, and Chronic Physical Aggression: Prospects for Early Protective Interventions
Translational Toxicology
DOI: 10.1007/978-3-319-27449-2_10
2016Dynamic Changes in DNA Methylation Occur during the First Year of Life in Preterm Infants
Frontiers in Endocrinology
Chinthika Piyasena and Jessy Cartier and Nadine Provençal and Tobias Wiechmann and Batbayar Khulan and Raju Sunderesan and Gopi Menon and Jonathan R. Seckl and Rebecca M. Reynolds and Elisabeth B. Binder and Amanda J. Drake
DOI: 10.3389/fendo.2016.00158
2016Epigenetics of Posttraumatic Stress Disorder: Current Evidence, Challenges, and Future Directions
Biological Psychiatry
Zannas, A.S. and Proven?al, N. and Binder, E.B.
DOI: 10.1016/j.biopsych.2015.04.003
2015The developmental origins of chronic physical aggression: Biological pathways triggered by early life adversity
Journal of Experimental Biology
Proven?al, N. and Booij, L. and Tremblay, R.E.
DOI: 10.1242/jeb.111401
2015Impact of Early Environment on Children's Mental Health: Lessons From DNA Methylation Studies With Monozygotic Twins
Twin Research and Human Genetics
Chiarella, J. and Tremblay, R.E. and Szyf, M. and Proven?al, N. and Booij, L.
DOI: 10.1017/thg.2015.84
2015The neurobiological effects of stress as contributors to psychiatric disorders: FOCUS on epigenetics
Current Opinion in Neurobiology
Provencal, N. and Binder, E.B.
DOI: 10.1016/j.conb.2014.08.007
2015The effects of early life stress on the epigenome: From the womb to adulthood and even before
Experimental Neurology
Proven?al, N. and Binder, E.B.
DOI: 10.1016/j.expneurol.2014.09.001
2015Hydroxymethylation and DNA methylation profiles in the prefrontal cortex of the non-human primate rhesus macaque and the impact of maternal deprivation on hydroxymethylation
Neuroscience
Massart, R. and Suderman, M. and Provencal, N. and Yi, C. and Bennett, A.J. and Suomi, S. and Szyf, M.
DOI: 10.1016/j.neuroscience.2014.03.021
2014DNA methylation signature of childhood chronic physical aggression in T cells of both men and women
PLoS ONE
Guillemin, C. and Proven?al, N. and Suderman, M. and Côté, S.M. and Vitaro, F. and Hallett, M. and Tremblay, R.E. and Szyf, M.
DOI: 10.1371/journal.pone.0086822
2014Epigenetics in posttraumatic stress disorder
Progress in Molecular Biology and Translational Science
Rampp, C. and Binder, E.B. and Proven?al, N.
DOI: 10.1016/B978-0-12-800977-2.00002-4
2014Association of childhood chronic physical aggression with a DNA methylation signature in adult human T cells
PLoS ONE
Proven?al, N. and Suderman, M.J. and Guillemin, C. and Vitaro, F. and Côté, S.M. and Hallett, M. and Tremblay, R.E. and Szyf, M.
DOI: 10.1371/journal.pone.0089839
2014Differential DNA methylation regions in cytokine and transcription factor genomic loci associate with childhood physical aggression.
PloS one
Proven?al, N. and Suderman, M.J. and Caramaschi, D. and Wang, D. and Hallett, M. and Vitaro, F. and Tremblay, R.E. and Szyf, M.
DOI: 10.1371/journal.pone.0071691
2013Childhood Chronic Physical Aggression Associates with Adult Cytokine Levels in Plasma
PLoS ONE
Proven?al, N. and Suderman, M.J. and Vitaro, F. and Szyf, M. and Tremblay, R.E.
DOI: 10.1371/journal.pone.0069481
2013The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells
Journal of Neuroscience
Proven?al, N. and Suderman, M.J. and Guillemin, C. and Massart, R. and Ruggiero, A. and Wang, D. and Bennett, A.J. and Pierre, P.J. and Friedman, D.P. and Côté, S.M. and Hallett, M. and Tremblay, R.E. and Suomi, S.J. and Szyf, M.
DOI: 10.1523/JNEUROSCI.1470-12.2012
2012Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression
PLoS ONE
Wang, D. and Szyf, M. and Benkelfat, C. and Proven?al, N. and Turecki, G. and Caramaschi, D. and Côté, S.M. and Vitaro, F. and Tremblay, R.E. and Booij, L.
DOI: 10.1371/journal.pone.0039501
2012Epigenetics and behaviour
Development and Prevention of Behaviour Problems: From Genes to Social Policy
Szyf, M. and Weaver, I. and Provencal, N. and McGowan, P.O. and Tremblay, R.E. and Meaney, M.J.
DOI: 10.4324/9780203868706
2009How does early life social environment sculpt our genes?
Biology of Reproduction
DOI: 10.1093/biolreprod/77.s1.64
07/2007Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines
Biochemical Pharmacology
Ou, J.-N. and Torrisani, J. and Unterberger, A. and Proven?al, N. and Shikimi, K. and Karimi, M. and Ekström, T.J. and Szyf, M.
DOI: 10.1016/j.bcp.2006.12.032
2007Analysis of a variable number tandem repeat polymorphism in the huntingtin interacting protein-1 related gene for anticipation in bipolar affective disorder
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Proven?al, N. and Shink, E. and Harvey, M. and Tremblay, M. and Barden, N.
DOI: 10.1016/j.pnpbp.2004.07.001
2004 - Research
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Grants
Bell Grant
Access to the Signature Biobank 2015-2016
Brain & Behavior Research Foundation
NARSAD Young Investigator Grant 2017-2019
Honours & AwardsFellowship Award, Canadian Institute of Health Research (CIHR) 2015-2017
Richard Todd Award, International Society of Psychiatric Genetics 2014
Research Group MembersEmily Barr, PhD Student
Maude Comtois-Cabana, PhD candidate
A new method makes it easier to study the connection between difficult experiences and mental health
A new method for analyzing targeted regions of the genome developed by Dr. Nadine Provençal and her colleagues is now making it faster and easier to do leading-edge epigenetic research by giving scientists a more accurate and efficient way to measure DNA methylation, a chemical tag on genes related to whether they’re turned “on” or “off.”
