Overview

Based on my interest in adherence research, socio-cultural aspects of medicine, child development and neurology (Ref# 1,2,3,4) I developed, in collaboration with medical anthropology and educational psychology, a comprehensive functional sleep/wake-behaviours assessment concept and began to transform physiological knowledge with questions of sleep health and management (Ref# 3,4,6,7).

In collaboration with the Cognitive Systems Lab at UBC, I have developed a 'Virtual-Sleep-Lab', where Videosomnography is used for screening ‘visible’ and ‘recognizable’ sleep disorders in children with neurodevelopmental disabilities/disorders in their natural setting, at home (Ref# 8,9,10). Based on this research, the Inter. RLS Consensus Group has included children with NDD in their recent Consensus Statement.

Publications

"Emplotted Narratives" and Structured "Behavioral Observations" Supporting the Diagnosis of Willis-Ekbom Disease/Restless Legs Syndrome in Children with Neurodevelopmental Conditions.
Ipsiroglu OS, Beyzaei N, Berger M, Wagner AL, Dhalla S, Garden J, Stockler S
DOI: 10.1111/cns.12564
PubMed: 27292821
06/2016

A randomized controlled trial of an intervention for infants' behavioral sleep problems.
Hall WA, Hutton E, Brant RF, Collet JP, Gregg K, Saunders R, Ipsiroglu O, Gafni A, Triolet K, Tse L, Bhagat R, Wooldridge J
DOI: 10.1186/s12887-015-0492-7
PubMed: 26567090
2015

"Diagnosis by behavioral observation" home-videosomnography - a rigorous ethnographic approach to sleep of children with neurodevelopmental conditions.
Ipsiroglu OS, Hung YH, Chan F, Ross ML, Veer D, Soo S, Ho G, Berger M, McAllister G, Garn H, Kloesch G, Barbosa AV, Stockler S, McKellin W, Vatikiotis-Bateson E
DOI: 10.3389/fpsyt.2015.00039
PubMed: 25852578
2015

"They silently live in terror…" why sleep problems and night-time related quality-of-life are missed in children with a fetal alcohol spectrum disorder.
Ipsiroglu OS, McKellin WH, Carey N, Loock C
DOI: 10.1016/j.socscimed.2012.10.027
PubMed: 23305724
02/2013

Cultural aspects in the management of inborn errors of metabolism.
Stockler S, Moeslinger D, Herle M, Wimmer B, Ipsiroglu OS
DOI: 10.1007/s10545-012-9455-4
PubMed: 22358739
11/2012

Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilities.
Jan JE, Bax MC, Owens JA, Ipsiroglu OS, Wasdell MB
DOI: 10.1016/j.ejpn.2012.01.002
PubMed: 22264650
09/2012

Sleep Health Issues for Children with FASD: Clinical Considerations.
Jan JE, Asante KO, Conry JL, Fast DK, Bax MC, Ipsiroglu OS, Bredberg E, Loock CA, Wasdell MB
DOI: 10.1155/2010/639048
PubMed: 20706655
2010

Sleep hygiene for children with neurodevelopmental disabilities.
Jan JE, Owens JA, Weiss MD, Johnson KP, Wasdell MB, Freeman RD, Ipsiroglu OS
DOI: 10.1542/peds.2007-3308
PubMed: 19047255
12/2008

Transcultural pediatrics: compliance and outcome of phenylketonuria patients from families with an immigration background.
Ipsiroglu OS, Herle M, Spoula E, Möslinger D, Wimmer B, Burgard P, Bode H, Stöckler-Ipsiroglu S
DOI: 10.1007/s00508-005-0327-x
PubMed: 16158204
08/2005

Effects of open vs. closed system endotracheal suctioning on cerebral blood flow velocities in mechanically ventilated extremely low birth weight infants.
Rieger H, Kuhle S, Ipsiroglu OS, Heinzl H, Popow CN
DOI: 10.1515/jpm.2005.077
PubMed: 16238539
2005

A novel technique to measure position-dependent resistance changes in the vertebral arteries postmortem: new insights into the aetiology of SIDS?
Wald M, Klupp N, Lawrenz K, Puig S, Heimberger K, Reiter C, Pollak A, Ipsiroglu O
DOI: 10.1080/08035250410027652
PubMed: 15384878
09/2004

Risk factors and natural history of habitual snoring.
Urschitz MS, Guenther A, Eitner S, Urschitz-Duprat PM, Schlaud M, Ipsiroglu OS, Poets CF
DOI: 10.1378/chest.126.3.790
PubMed: 15364758
09/2004

Classification of sudden infant death (SID) cases in a multidisciplinary setting. Ten years experience in Styria (Austria).
Kerbl R, Zotter H, Einspieler C, Roll P, Ratschek M, Köstl G, Strenger V, Hoffmann E, Perrogon A, Zötsch W, Schober P, Gränz A, Sauseng W, Bachler I, Kenner T, Ipsiroglu O, Kurz R, Styrian Sudden Infant Death Study Group
DOI: 10.1007/bf03040411
PubMed: 14768536
12/2003

[Snoring as an sign of sleep disorders in 11- to 15-year-old school children--initial results of a Vienna epidemiologic study].
Török K, Fatemi A, Werner I, Kerbl R, Schwarz B, Ipsiroglu OS
DOI: 10.1007/bf03040406
PubMed: 14768531
12/2003

[Sudden infant death and pediatric sleep medicine].
Förster H, Ipsiroglu O, Kerbl R, Paditz E
DOI: 10.1007/bf03040402
PubMed: 14768527
12/2003

Self-reported organic and nonorganic sleep problems in schoolchildren aged 11 to 15 years in Vienna.
Ipsiroglu OS, Fatemi A, Werner I, Paditz E, Schwarz B
DOI: 10.1016/s1054-139x(02)00423-8
PubMed: 12401431
11/2002

[Sudden infant death in Austria--status quo and recommendations of the SIDS Consensus Working Group for Improved Registration].
Ipsiroglu OS, Fatemi A, Rabl W, Klupp N, Roll P, Meyer H, Kerbl R, Kurz R
PubMed: 12416287
09/2002

Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy.
Plecko B, Stoeckler-Ipsiroglu S, Schober E, Harrer G, Mlynarik V, Gruber S, Moser E, Moeslinger D, Silgoner H, Ipsiroglu O
DOI: 10.1203/00006450-200208000-00025
PubMed: 12149510
08/2002

Effects of oral creatine supplementation in a patient with MELAS phenotype and associated nephropathy.
Barisic N, Bernert G, Ipsiroglu O, Stromberger C, Müller T, Gruber S, Prayer D, Moser E, Bittner RE, Stöckler-Ipsiroglu S
DOI: 10.1055/s-2002-33679
PubMed: 12200746
06/2002

Sudden infant death: no evidence for linkage to common polymorphisms in the uncoupling protein-1 and the beta3-adrenergic receptor genes.
Fatemi A, Item C, Stöckler-Ipsiroglu S, Ipsiroglu O, Sperl W, Patsch W, Strobl W
DOI: 10.1007/s00431-002-0940-x
PubMed: 12029453
06/2002

Position dependent changes of cerebral blood flow velocities in premature infants.
Eichler F, Ipsiroglu O, Arif T, Popow C, Heinzl H, Urschitz M, Pollak A
DOI: 10.1007/s004310100806
PubMed: 11686511
10/2001

Can hypocapnia reduce cerebral embolization during cardiopulmonary bypass?
Plöchl W, Krenn CG, Cook DJ, Gollob E, Pezawas T, Schima H, Ipsiroglu O, Wollenek G, Grubhofer G
DOI: 10.1016/s0003-4975(01)02826-0
PubMed: 11565668
09/2001

Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species.
Ipsiroglu OS, Stromberger C, Ilas J, Höger H, Mühl A, Stöckler-Ipsiroglu S
DOI: 10.1016/s0024-3205(01)01268-1
PubMed: 11665842
08/2001

[Communication barriers in the management of immigrants and their children. An analysis and possible solutions based on case reports]
Wimmer B, Ipsiroglu OS
PubMed: 11571841
08/2001

[Sleep medicine between science and clinical practice--how long can we avoid the issue?]
Ipsiroglu OS, Saletu B
PubMed: 11383379
04/2001

[Prevalence of sleep disorders in school children between 11 and 15 years of age]
Ipsiroglu OS, Fatemi A, Werner I, Tiefenthaler M, Urschitz MS, Schwarz B
PubMed: 11383383
04/2001

[Orthostasis in halothane anesthesia. A model situation for studying cerebrovascular autoregulation in infants]
Ipsiroglu OS, Köhler J, Meger B, Pumberger W, Grabner C, Semsroth M
DOI: 10.1007/s001010070091
PubMed: 10928253
06/2000

[Viennese SIDS prevention campaign-- a quality management project]
Ipsiroglu OS, Stekel H, Pollak A, Kaspar L
PubMed: 10763535
03/2000

SIDS related anxiety--a risk factor analysis.
Leitich H, Tiefenthaler M, Popow C, Seyfried-Holzer G, Urschitz M, Ipsiroglu OS, Pollak A
PubMed: 10763534
03/2000

[4th Austrian SIDS Consensus-Consultation and the Viennese SIDS prevention campaign "Secure Sleep"]
Ipsiroglu OS, Kerbl R, Urschitz M, Kurz R
PubMed: 10763529
03/2000

[Evaluation of the cardiorespiratory monitor SpiroGuard C for infants. Improved registration of respiratory events by new sensors and intelligent alarm management system]
Urschitz MS, Eichler F, Popow C, Ipsiroglu OS
PubMed: 10763536
03/2000

[Secure Sleep--SIDS prevention campaign by children's hospitals of Vienna]
Ipsiroglu OS, Lischka A, Sacher M, Stögmann W, Pollak A
PubMed: 10763528
03/2000

Estimating percentage total body fat and determining subcutaneous adipose tissue distribution with a new noninvasive optical device LIPOMETER.
Möller R, Tafeit E, Smolle KH, Pieber TR, Ipsiroglu O, Duesse M, Huemer C, Sudi K, Reibnegger G
DOI: 10.1002/(sici)1520-6300(200003/04)12:23.0.co;2-2
PubMed: 11534019
03/2000

[Heart rate variability--physiology, methods of registration and application in pediatric sleep laboratory]
Patzak A, Mrowka R, Springer S, Eckard T, Ipsiroglu OS, Erler T, Hofmann S
PubMed: 10763537
03/2000

[Diagnostic imaging in neonatal stroke].
Kuhle S, Ipsiroglu O, Puig S, Weninger M, Prayer D
DOI: 10.1007/s001170050005
PubMed: 10663160
01/2000

Systemic blood pressure and cerebral blood flow velocity during carotid surgery.
Grubhofer G, Lassnigg A, Pernerstorfer T, Ipsiroglu O, Czerny M, Polterauer P, Hiesmayr M
PubMed: 10670796
12/1999

Cerebral Doppler sonography of the neonate. A resume after 20 years and future aspects.
Ipsiroglu OS, Eichler F, Stoeckler-Ipsiroglu S
PubMed: 10572729
12/1999

Cerebral blood flow velocities in an infant with moyamoya disease.
Ipsiroglu OS, Eichler F, Stöckler-Ipsiroglu S, Trattnig S
DOI: 10.1016/s0887-8994(99)00070-3
PubMed: 10580888
10/1999

Are adult transcranial Doppler systems suitable for application in neonates?
Ipsiroglu OS, Steck J, Michel E, Pessenhofer H, Jorch G, Pollak A
DOI: 10.1007/bf02282884
PubMed: 8911894
11/1996

Cerebral blood flow velocities in the first minutes of life.
Ipsiroglu OS, Stöckler S, Häusler MC, Kainer F, Rosegger H, Weiss PA, Winter R
DOI: 10.1007/bf01956162
PubMed: 8444260
03/1993

[Dys-tocolysis: modified vaginal delivery of premature infants?]
Ipsiroglu OS, Rosegger H, Weiss PA
PubMed: 2079278
1990

[The value of umbilical cord blood cortisol]
Ipsiroglu OS, Semmelrock J, Gmoser G, Stöckler S, Rosegger H
PubMed: 2079268
1990

[Pregnancy and neonatal screening in Austria]
Stöckler S, Ipsiroglu OS, Häusler M
PubMed: 2678759
09/1989

[The value of prenatal ultrasound screening exemplified by abnormalities of the urogenital system. Data from the Styrian malformation register 1985 to 1987]
Häusler M, Hofmann HM, Schaffer M, Hofer P, Rollett H, Ring E, Ipsiroglu OS
PubMed: 2660419
05/1989

[Congenital metabolic diseases as a cause of acute illnesses in the neonatal period]
Stöckler S, Ipsiroglu OS, Paschke E
PubMed: 2677512
1989

[Steiermark data of congenital abnormalities with regional classification and comparative international values]
Häusler M, Hofmann HM, Hofer P, Schaffer M, Ipsiroglu O
PubMed: 2613025
1989

Research

NeuroDevNet "Better Days/Better Nights"
SWAPPs 4KIDS with NDDs. Structured functional Sleep/Wake Behaviour assessment in children with neurodevelopmental disabilities/disorders & monitoring therapeutic interventions.

Overview: Our team has developed a web app (sleep/wake behaviours App, SWAPP) to facilitate recognition, characterization and monitoring of sleep problems (SPs) and daytime sequelae in children and youth with neurodevelopmental disabilities (NDDs) [http://youtu.be/60Kx4jmU6Is]. The use of the SWAPP in clinical practice has created evidence for revisiting clinical practice guidelines and improving existing policies by highlighting the fundamental need, to recognize and appropriately treat sleep problems in most vulnerable populations. We collaborate with a network of multidisciplinary stakeholders, including non-governmental organizations (representing patients) and recently with decision makers to ensure rapid and sustainable implementation and policy change.

Objectives of our research: Further development of the SWAPP and associated database. We are particularly interested in medication strategies, captured by the medication module for monitoring psychotropic drug prescriptions and behavioural / neurologic adverse drug reactions. A free downloadable smart-phone version of our SWAPP for caregivers and practitioners to (self-)assess / recognize the concept of challenging sleep / wake behaviours will be ready around fall 2015.

Significance: At the end of the project we will have a series of validated and commercially available SWAPPs with patient driven self-assessment modules for participatory data collection on poorly understood challenging-disruptive sleep/wake behaviours. Patient and community tier input during all stages of development will result in effective implementation of the SWAPPs through knowledge translation activities in collaboration with non-governmental organizations.

Grants

2009-2012: Canadian Institute of Health Research. Night waking reduction in Canadian infants: a randomized clinical trial of a parent based cognitive and behavioural intervention in community health units. (Co-PI, PI: Dr. Wendy Hall)

2013/2014: Peter Wall Institute for Advanced Studies: Visiting Scholar Funding for Dr. Karen Spruyt, Vrije Universiteit, Brussels (together with Dr. Sylvia Stockler)

2012: Peter Wall Institute for Advanced Studies: Phenotyping Sleep Behaviours Lessons from the Past, Directions for the Future (together with Dr. Bruce Carleton)

Honours & Awards

2011: Excellence in Education Award, Learning & Development BC Children's hospital & BC Women's Hospital & Health Care

2008: Transcultural Paediatrics Award, German Society for Socialpaediatrics & Adolescent Medicine and Austrian Society of Paediatrics

Research Group Members

Jyhyun Cho
Audrey Basic
Harvey Lee, Volunteer
Christopher Leong
Marina Godard, Undergraduate Student
Mikayla Hong, Undergraduate Student
Zhaochen Meng, Medical Student
Sabrina Chan, Volunteer
Yufeng Xiao
Sayeed Mavani, Volunteer
Michelle Ngai, Undergraduate Student
Krystal Go
Roman Johnson, Research Volunteer
Nadia Beyzaei
Lu Bao
Lourdes Garcia Rodriguez, Research Volunteer
Hebah Hussaina
Mikayla Wohlleben
Renee Boldut, High School Student
Emmanuel Tse
Ishmeet Singh
Kaylin Xu, High School Student
Kanak Jaitli