BC Children's Hospital Research Institute is pleased to congratulate the recipients of the 2018 Outstanding Achievement Awards and the 2018 BCCHR Studentships and Fellowships.
Based on my interest in adherence research, socio-cultural aspects of medicine, child development and neurology (Ref# 1,2,3,4) I developed, in collaboration with medical anthropology and educational psychology, a comprehensive functional sleep/wake-behaviours assessment concept and began to transform physiological knowledge with questions of sleep health and management (Ref# 3,4,6,7).
In collaboration with the Cognitive Systems Lab at UBC, I have developed a 'Virtual-Sleep-Lab', where Videosomnography is used for screening ‘visible’ and ‘recognizable’ sleep disorders in children with neurodevelopmental disabilities/disorders in their natural setting, at home (Ref# 8,9,10). Based on this research, the Inter. RLS Consensus Group has included children with NDD in their recent Consensus Statement.
"Emplotted Narratives" and Structured "Behavioral Observations" Supporting the Diagnosis of Willis-Ekbom Disease/Restless Legs Syndrome in Children with Neurodevelopmental Conditions.
Ipsiroglu OS, Beyzaei N, Berger M, Wagner AL, Dhalla S, Garden J, Stockler S
A randomized controlled trial of an intervention for infants' behavioral sleep problems.
Hall WA, Hutton E, Brant RF, Collet JP, Gregg K, Saunders R, Ipsiroglu O, Gafni A, Triolet K, Tse L, Bhagat R, Wooldridge J
"Diagnosis by behavioral observation" home-videosomnography - a rigorous ethnographic approach to sleep of children with neurodevelopmental conditions.
Ipsiroglu OS, Hung YH, Chan F, Ross ML, Veer D, Soo S, Ho G, Berger M, McAllister G, Garn H, Kloesch G, Barbosa AV, Stockler S, McKellin W, Vatikiotis-Bateson E
"They silently live in terror…" why sleep problems and night-time related quality-of-life are missed in children with a fetal alcohol spectrum disorder.
Ipsiroglu OS, McKellin WH, Carey N, Loock C
Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilities.
Jan JE, Bax MC, Owens JA, Ipsiroglu OS, Wasdell MB
Sleep Health Issues for Children with FASD: Clinical Considerations.
Jan JE, Asante KO, Conry JL, Fast DK, Bax MC, Ipsiroglu OS, Bredberg E, Loock CA, Wasdell MB
Transcultural pediatrics: compliance and outcome of phenylketonuria patients from families with an immigration background.
Ipsiroglu OS, Herle M, Spoula E, Möslinger D, Wimmer B, Burgard P, Bode H, Stöckler-Ipsiroglu S
Effects of open vs. closed system endotracheal suctioning on cerebral blood flow velocities in mechanically ventilated extremely low birth weight infants.
Rieger H, Kuhle S, Ipsiroglu OS, Heinzl H, Popow CN
A novel technique to measure position-dependent resistance changes in the vertebral arteries postmortem: new insights into the aetiology of SIDS?
Wald M, Klupp N, Lawrenz K, Puig S, Heimberger K, Reiter C, Pollak A, Ipsiroglu O
Classification of sudden infant death (SID) cases in a multidisciplinary setting. Ten years experience in Styria (Austria).
Kerbl R, Zotter H, Einspieler C, Roll P, Ratschek M, Köstl G, Strenger V, Hoffmann E, Perrogon A, Zötsch W, Schober P, Gränz A, Sauseng W, Bachler I, Kenner T, Ipsiroglu O, Kurz R, Styrian Sudden Infant Death Study Group
[Snoring as an sign of sleep disorders in 11- to 15-year-old school children--initial results of a Vienna epidemiologic study].
Török K, Fatemi A, Werner I, Kerbl R, Schwarz B, Ipsiroglu OS
Self-reported organic and nonorganic sleep problems in schoolchildren aged 11 to 15 years in Vienna.
Ipsiroglu OS, Fatemi A, Werner I, Paditz E, Schwarz B
[Sudden infant death in Austria--status quo and recommendations of the SIDS Consensus Working Group for Improved Registration].
Ipsiroglu OS, Fatemi A, Rabl W, Klupp N, Roll P, Meyer H, Kerbl R, Kurz R
Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy.
Plecko B, Stoeckler-Ipsiroglu S, Schober E, Harrer G, Mlynarik V, Gruber S, Moser E, Moeslinger D, Silgoner H, Ipsiroglu O
Effects of oral creatine supplementation in a patient with MELAS phenotype and associated nephropathy.
Barisic N, Bernert G, Ipsiroglu O, Stromberger C, Müller T, Gruber S, Prayer D, Moser E, Bittner RE, Stöckler-Ipsiroglu S
Sudden infant death: no evidence for linkage to common polymorphisms in the uncoupling protein-1 and the beta3-adrenergic receptor genes.
Fatemi A, Item C, Stöckler-Ipsiroglu S, Ipsiroglu O, Sperl W, Patsch W, Strobl W
Position dependent changes of cerebral blood flow velocities in premature infants.
Eichler F, Ipsiroglu O, Arif T, Popow C, Heinzl H, Urschitz M, Pollak A
Can hypocapnia reduce cerebral embolization during cardiopulmonary bypass?
Plöchl W, Krenn CG, Cook DJ, Gollob E, Pezawas T, Schima H, Ipsiroglu O, Wollenek G, Grubhofer G
Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species.
Ipsiroglu OS, Stromberger C, Ilas J, Höger H, Mühl A, Stöckler-Ipsiroglu S
[Communication barriers in the management of immigrants and their children. An analysis and possible solutions based on case reports]
Wimmer B, Ipsiroglu OS
[Sleep medicine between science and clinical practice--how long can we avoid the issue?]
Ipsiroglu OS, Saletu B
[Prevalence of sleep disorders in school children between 11 and 15 years of age]
Ipsiroglu OS, Fatemi A, Werner I, Tiefenthaler M, Urschitz MS, Schwarz B
[Orthostasis in halothane anesthesia. A model situation for studying cerebrovascular autoregulation in infants]
Ipsiroglu OS, Köhler J, Meger B, Pumberger W, Grabner C, Semsroth M
[Viennese SIDS prevention campaign-- a quality management project]
Ipsiroglu OS, Stekel H, Pollak A, Kaspar L
SIDS related anxiety--a risk factor analysis.
Leitich H, Tiefenthaler M, Popow C, Seyfried-Holzer G, Urschitz M, Ipsiroglu OS, Pollak A
[4th Austrian SIDS Consensus-Consultation and the Viennese SIDS prevention campaign "Secure Sleep"]
Ipsiroglu OS, Kerbl R, Urschitz M, Kurz R
[Evaluation of the cardiorespiratory monitor SpiroGuard C for infants. Improved registration of respiratory events by new sensors and intelligent alarm management system]
Urschitz MS, Eichler F, Popow C, Ipsiroglu OS
[Secure Sleep--SIDS prevention campaign by children's hospitals of Vienna]
Ipsiroglu OS, Lischka A, Sacher M, Stögmann W, Pollak A
Estimating percentage total body fat and determining subcutaneous adipose tissue distribution with a new noninvasive optical device LIPOMETER.
Möller R, Tafeit E, Smolle KH, Pieber TR, Ipsiroglu O, Duesse M, Huemer C, Sudi K, Reibnegger G
[Heart rate variability--physiology, methods of registration and application in pediatric sleep laboratory]
Patzak A, Mrowka R, Springer S, Eckard T, Ipsiroglu OS, Erler T, Hofmann S
Systemic blood pressure and cerebral blood flow velocity during carotid surgery.
Grubhofer G, Lassnigg A, Pernerstorfer T, Ipsiroglu O, Czerny M, Polterauer P, Hiesmayr M
Cerebral Doppler sonography of the neonate. A resume after 20 years and future aspects.
Ipsiroglu OS, Eichler F, Stoeckler-Ipsiroglu S
[Dys-tocolysis: modified vaginal delivery of premature infants?]
Ipsiroglu OS, Rosegger H, Weiss PA
[The value of umbilical cord blood cortisol]
Ipsiroglu OS, Semmelrock J, Gmoser G, Stöckler S, Rosegger H
[Pregnancy and neonatal screening in Austria]
Stöckler S, Ipsiroglu OS, Häusler M
[The value of prenatal ultrasound screening exemplified by abnormalities of the urogenital system. Data from the Styrian malformation register 1985 to 1987]
Häusler M, Hofmann HM, Schaffer M, Hofer P, Rollett H, Ring E, Ipsiroglu OS
[Congenital metabolic diseases as a cause of acute illnesses in the neonatal period]
Stöckler S, Ipsiroglu OS, Paschke E
[Steiermark data of congenital abnormalities with regional classification and comparative international values]
Häusler M, Hofmann HM, Hofer P, Schaffer M, Ipsiroglu O
NeuroDevNet "Better Days/Better Nights"
SWAPPs 4KIDS with NDDs. Structured functional Sleep/Wake Behaviour assessment in children with neurodevelopmental disabilities/disorders & monitoring therapeutic interventions.
Overview: Our team has developed a web app (sleep/wake behaviours App, SWAPP) to facilitate recognition, characterization and monitoring of sleep problems (SPs) and daytime sequelae in children and youth with neurodevelopmental disabilities (NDDs) [http://youtu.be/60Kx4jmU6Is]. The use of the SWAPP in clinical practice has created evidence for revisiting clinical practice guidelines and improving existing policies by highlighting the fundamental need, to recognize and appropriately treat sleep problems in most vulnerable populations. We collaborate with a network of multidisciplinary stakeholders, including non-governmental organizations (representing patients) and recently with decision makers to ensure rapid and sustainable implementation and policy change.
Objectives of our research: Further development of the SWAPP and associated database. We are particularly interested in medication strategies, captured by the medication module for monitoring psychotropic drug prescriptions and behavioural / neurologic adverse drug reactions. A free downloadable smart-phone version of our SWAPP for caregivers and practitioners to (self-)assess / recognize the concept of challenging sleep / wake behaviours will be ready around fall 2015.
Significance: At the end of the project we will have a series of validated and commercially available SWAPPs with patient driven self-assessment modules for participatory data collection on poorly understood challenging-disruptive sleep/wake behaviours. Patient and community tier input during all stages of development will result in effective implementation of the SWAPPs through knowledge translation activities in collaboration with non-governmental organizations.Grants
2009-2012: Canadian Institute of Health Research. Night waking reduction in Canadian infants: a randomized clinical trial of a parent based cognitive and behavioural intervention in community health units. (Co-PI, PI: Dr. Wendy Hall)
2013/2014: Peter Wall Institute for Advanced Studies: Visiting Scholar Funding for Dr. Karen Spruyt, Vrije Universiteit, Brussels (together with Dr. Sylvia Stockler)
2012: Peter Wall Institute for Advanced Studies: Phenotyping Sleep Behaviours Lessons from the Past, Directions for the Future (together with Dr. Bruce Carleton)Honours & Awards
2011: Excellence in Education Award, Learning & Development BC Children's hospital & BC Women's Hospital & Health Care
2008: Transcultural Paediatrics Award, German Society for Socialpaediatrics & Adolescent Medicine and Austrian Society of PaediatricsResearch Group Members
Harvey Lee, Volunteer
Marina Godard, Undergraduate Student
Mikayla Hong, Undergraduate Student
Zhaochen Meng, Medical Student
Sabrina Chan, Volunteer
Sayeed Mavani, Volunteer
Michelle Ngai, Undergraduate Student
Roman Johnson, Research Volunteer
Lourdes Garcia Rodriguez, Research Volunteer
Renee Boldut, High School Student
Kaylin Xu, High School Student