Congratulations to the BC Children's Hospital Research Institute (BCCHR) and Women’s Health Research Institute (WHRI) investigators and their teams who were awarded funding through the Canadian Institutes of Health Research (CIHR) Fall 2021 Project Grant competition. Our research community received around $6 million in new research grants as principal investigators or co-investigators.
- Overview
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In Canada, rheumatic conditions are the most common chronic illness of childhood, affecting as many as 10 000 of our children and youth. Examples of rheumatic diseases are juvenile idiopathic arthritis, lupus, vasculitis and autoinflammatory conditions. The common denominator for all is pain and / or inflammation in joints, muscles, and critical organs. Some diseases are life- or organ- threatening and all have significant potential for lifelong poor health and disability. There are no cures and remarkably few treatments that are specific and safe for a growing child. My research program is designed to generate an evidence base for clinical decisions that ultimately improve outcomes for Canadian children and families affected by rheumatic disease.
- Publications
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Anti-LAMP-2 Antibody Seropositivity in Children with Primary Systemic Vasculitis Affecting Medium- and Large-Sized Vessels
International Journal of Molecular Sciences
DOI: 10.3390/ijms25073771
2024Predictive utility of ANCA positivity and antigen specificity in the assessment of kidney disease in paediatric-onset small vessel vasculitis
RMD Open
DOI: 10.1136/rmdopen-2024-004315
2024Editorial: Innate immunity in vasculitis
Frontiers in Immunology
DOI: 10.3389/fimmu.2024.1432069
2024Elevated ADA2 Enzyme Activity at the Onset of Chronic Graft-versus-Host Disease in Children
Transplantation and Cellular Therapy
DOI: 10.1016/j.jtct.2023.02.014
2023Hyaluronan promotes intracellular ROS production and apoptosis in TNFa-stimulated neutrophils
Frontiers in Immunology
DOI: 10.3389/fimmu.2023.1032469
2023Behçet’s syndrome: recent advances to aid diagnosis
Clinical and Experimental Medicine
DOI: 10.1007/s10238-023-01226-7
2023Association Between HLA–DPB1 and Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in Children
Arthritis and Rheumatology
DOI: 10.1002/art.42423
2023Pathogenic variant c.1052T>A (p.Leu351Gln) in adenosine deaminase 2 impairs secretion and elevates type I IFN responsive gene expression
Frontiers in Immunology
Bowers, S.M. and Sundqvist, M. and Dancey, P. and Cabral, D.A. and Brown, K.L.
DOI: 10.3389/fimmu.2022.995191
2022Galectin-3 Modulates Microglia Inflammation in vitro but Not Neonatal Brain Injury in vivo under Inflammatory Conditions
Developmental Neuroscience
Sävman, K. and Wang, W. and Rafati, A.H. and Svedin, P. and Nair, S. and Golubinskaya, V. and Ardalan, M. and Brown, K.L. and Karlsson-Bengtsson, A. and Mallard, C.
DOI: 10.1159/000517687
2021Latent gammaherpesvirus exacerbates arthritis and requires age-associated B cells
bioRxiv
Mouat, I.C. and Morse, Z.J. and Shanina, I. and Brown, K.L. and Horwitz, M.S.
DOI: 10.1101/2021.02.02.429395
2021Children with systemic autoinflammatory diseases have multiple, mixed ethnicities that reflect regional ethnic diversity
Clinical and Experimental Rheumatology
Tucker, L.B. and Niemietz, I. and Mangat, P. and Belen, M. and Tekano, J. and Cabral, D.A. and Guzman, J. and Houghton, K.M. and Morishita, K.A. and Chan, M.O. and Human, A. and Sundqvist, M. and Brown, K.L.
2021Different Disease Endotypes in Phenotypically Similar Vasculitides Affecting Small-to-Medium Sized Blood Vessels
Frontiers in Immunology
Gill, E.E. and Smith, M.L. and Gibson, K.M. and Morishita, K.A. and Lee, A.H.Y. and Falsafi, R. and Graham, J. and Foell, D. and Benseler, S.M. and Ross, C.J. and Luqmani, R.A. and Cabral, D.A. and Hancock, R.E.W. and Brown, K.L.
DOI: 10.3389/fimmu.2021.638571
2021Autoantibodies Against Lysosome Associated Membrane Protein-2 (LAMP-2) in Pediatric Chronic Primary Systemic Vasculitis
Frontiers in Immunology
Gibson, K.M. and Kain, R. and Luqmani, R.A. and Ross, C.J. and Cabral, D.A. and Brown, K.L.
DOI: 10.3389/fimmu.2020.624758
2021Latent gammaherpesvirus exacerbates arthritis through modification of age-associated b cells
eLife
Mouat, I.C. and Morse, Z.J. and Shanina, I. and Brown, K.L. and Horwitz, M.S.
DOI: 10.7554/eLife.67024
2021Adenosine deaminase 2 activity negatively correlates with age during childhood
Pediatric Rheumatology
Sarah M. Bowers and Kristen M. Gibson and David A. Cabral and Kelly L. Brown
DOI: 10.1186/s12969-020-00446-5
07/2020Anti-neutrophil cytoplasmic antibodies (ANCA): Antigen interactions and downstream effects
Journal of Leukocyte Biology
Sundqvist, M. and Gibson, K.M. and Bowers, S.M. and Niemietz, I. and Brown, K.L.
DOI: 10.1002/JLB.3VMR0220-438RR
2020Hyaluronan primes the oxidative burst in human neutrophils
Journal of Leukocyte Biology
Niemietz, I. and Moraes, A.T. and Sundqvist, M. and Brown, K.L.
DOI: 10.1002/JLB.3MA0220-216RR
2020Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): A framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group
Pediatric Rheumatology
Amarilyo, G. and Rothman, D. and Manthiram, K. and Edwards, K.M. and Li, S.C. and Marshall, G.S. and Yildirim-Toruner, C. and Haines, K. and Ferguson, P.J. and Lionetti, G. and Cherian, J. and Zhao, Y. and Delamora, P. and Syverson, G. and Nativ, S. and Twilt, M. and Michelow, I.C. and Stepanovskiy, Y. and Thatayatikom, A. and Harel, L. and Akoghlanian, S. and Tucker, L. and Marques, M.C. and Srinivasalu, H. and Propst, E.J. and Licameli, G.R. and Dedeoglu, F. and Lapidus, S. and Laxer, R. and Imundo, L. and Tsoukas, P. and Wright, P. and Brown, K. and Khasawneh, R. and Scuccimarri, R. and Mulvihill, E. and Aabo, M. and Anderson, E. and Abramson, L. and Adelean, D. and Dumez, D. and Guzman, M. and Pang, R. and Go, E. and Koranyi, K. and Goldsmith, D. and Kim, H. and Zeft, A. and Schnieder, R. and Statler, V. and Steele, L. and Broderick, L. and Hoffman, H. and Grevich, S.C. and Chalom, E. and Cidon, M. and Sundel, R. and Saad, N. and McCurdy, D. and Schulert, G. and Yalcindag, A. and Yen, E. and Stern, S. and Durrant, K. and Butbul, Y. and Hausmann, J.
DOI: 10.1186/s12969-020-00424-x
2020Methods for type I interferon detection and their relevance for clinical utility and improved understanding of rheumatic diseases.
Clinical and experimental rheumatology
Lamot L and Niemietz I and Brown KL
PubMed: 30943143
03/2019Monocyte-Derived Interleukin-1ß As the Driver of S100A12-Induced Sterile Inflammatory Activation of Human Coronary Artery Endothelial Cells: Implications for the Pathogenesis of Kawasaki Disease
Arthritis and Rheumatology
Armaroli, G. and Verweyen, E. and Pretzer, C. and Kessel, K. and Hirono, K. and Ichida, F. and Okabe, M. and Cabral, D.A. and Foell, D. and Brown, K.L. and Kessel, C.
DOI: 10.1002/art.40784
2019Complexity in unclassified auto-inflammatory disease: A case report illustrating the potential for disease arising from the allelic burden of multiple variants
Pediatric Rheumatology
Tucker, L.B. and Lamot, L. and Niemietz, I. and Chung, B.K. and Cabral, D.A. and Houghton, K. and Petty, R.E. and Morishita, K.A. and Rice, G.I. and Turvey, S.E. and Gibson, W.T. and Brown, K.L.
DOI: 10.1186/s12969-019-0374-x
2019Comparable type i interferon score determination from PAXgene and Tempus whole blood RNA collection and isolation systems
BMC Research Notes
Lamot, L. and Niemietz, I. and Brown, K.L.
DOI: 10.1186/s13104-019-4562-z
2019Methods for type I interferon detection and their relevance for clinical utility and improved understanding of rheumatic diseases
Clinical and experimental rheumatology
Lamot, L. and Niemietz, I. and Brown, K.L.
2019Periodic fever syndromes: Beyond the single gene paradigm
Pediatric Rheumatology
Westwell-Roper, C. and Niemietz, I. and Tucker, L.B. and Brown, K.L.
DOI: 10.1186/s12969-019-0324-7
2019Identification of Novel Adenosine Deaminase 2 Gene Variants and Varied Clinical Phenotype in Pediatric Vasculitis
Arthritis and Rheumatology
Gibson, K.M. and Morishita, K.A. and Dancey, P. and Moorehead, P. and Drögemöller, B. and Han, X. and Graham, J. and Hancock, R.E.W. and Foell, D. and Benseler, S. and Luqmani, R. and Yeung, R.S.M. and Shenoi, S. and Bohm, M. and Rosenberg, A.M. and Ross, C.J. and Cabral, D.A. and Brown, K.L.
DOI: 10.1002/art.40913
2019The value of creativity for enhancing translational ecologies, insights, and discoveries
Frontiers in Psychology
Goeltzenleuchter, B. and Suchtelen, A. and Brown, K.L. and Grompone, G.
DOI: 10.3389/fpsyg.2019.00951
2019Measles Lymphadenopathy in a Child With PFAPA Syndrome
Pediatric and Developmental Pathology
Terry, J. and Brown, K. and Hiebert, J. and Al-Rawahi, G.N. and Moxham, J.P. and Krajden, M. and Jassem, A.N. and Tucker, L.
DOI: 10.1177/1093526617727970
2018S100A12 Serum Levels and PMN counts are elevated in childhood systemic vasculitides especially involving proteinase 3 specific anti-neutrophil cytoplasmic antibodies
Frontiers in Pediatrics
Brown, K.L. and Lubieniecka, J.M. and Armaroli, G. and Kessel, K. and Gibson, K.M. and Graham, J. and Liu, D. and W. Hancock, R.E. and Ross, C.J. and Benseler, S.M. and Luqmani, R.A. and Cabral, D.A. and Foell, D. and Kessel, C.
DOI: 10.3389/fped.2018.00341
2018The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus
Clinical Immunology
Ragotte, R.J. and Dhanrajani, A. and Pleydell-Pearce, J. and Del Bel, K.L. and Tarailo-Graovac, M. and van Karnebeek, C. and Terry, J. and Senger, C. and McKinnon, M.L. and Seear, M. and Prendiville, J.S. and Tucker, L.B. and Houghton, K. and Cabral, D.A. and Guzman, J. and Petty, R.E. and Brown, K.L. and Tekano, J. and Wu, J. and Morishita, K.A. and Turvey, S.E.
DOI: 10.1016/j.clim.2016.12.006
2017Elevated mitochondrial reactive oxygen species and cellular redox imbalance in human NADPH-oxidase-deficient phagocytes
Frontiers in Immunology
Sundqvist, M. and Christenson, K. and Björnsdottir, H. and Osla, V. and Karlsson, A. and Dahlgren, C. and Speert, D.P. and Fasth, A. and Brown, K.L. and Bylund, J.
DOI: 10.3389/fimmu.2017.01828
2017Clinical practice variation and need for pediatric-specific treatment guidelines among rheumatologists caring for children with ANCA-associated vasculitis: An international clinician survey
Pediatric Rheumatology
Westwell-Roper, C. and Lubieniecka, J.M. and Brown, K.L. and Morishita, K.A. and Mammen, C. and Wagner-Weiner, L. and Yen, E. and Li, S.C. and O'Neil, K.M. and Lapidus, S.K. and Brogan, P. and Cimaz, R. and Cabral, D.A.
DOI: 10.1186/s12969-017-0191-z
2017Endotoxin free hyaluronan and hyaluronan fragments do not stimulate TNF-a, interleukin-12 or upregulate co-stimulatory molecules in dendritic cells or macrophages
Scientific Reports
Dong, Y. and Arif, A. and Olsson, M. and Cali, V. and Hardman, B. and Dosanjh, M. and Lauer, M. and Midura, R.J. and Hascall, V.C. and Brown, K.L. and Johnson, P.
DOI: 10.1038/srep36928
2016Temporal characterization of microglia/macrophage phenotypes in a mouse model of neonatal hypoxic-ischemic brain injury
Frontiers in Cellular Neuroscience
Erkenstam, N.H. and Smith, P.L.P. and Fleiss, B. and Nair, S. and Svedin, P. and Wang, W. and Boström, M. and Gressens, P. and Hagberg, H. and Brown, K.L. and Sävman, K. and Mallard, C.
DOI: 10.3389/fncel.2016.00286
2016Purified hyaluronan and hyaluronan fragments do not stimulate pro-inflammatory cytokine production in dendritic cells or macrophages
Scientific Reports
PubMed: 27869206
2016The where, when, how and why of hyaluronan binding by immune cells
Frontiers in Immunology
Lee-Sayer, S.S.M. and Dong, Y. and Arif, A.A. and Olsson, M. and Brown, K.L. and Johnson, P.
DOI: 10.3389/fimmu.2015.00150
2015Pediatric vasculitis: Advances in treatment
Current Opinion in Rheumatology
Morishita, K. and Brown, K. and Cabral, D.
DOI: 10.1097/BOR.0000000000000203
2015Innate defense regulator peptide 1018 protects against perinatal brain injury
Annals of Neurology
Bolouri, H. and Sävman, K. and Wang, W. and Thomas, A. and Maurer, N. and Dullaghan, E. and Fjell, C.D. and Ek, C.J. and Hagberg, H. and Hancock, R.E.W. and Brown, K.L. and Mallard, C.
DOI: 10.1002/ana.24087
2014Host Defence (Antimicrobial) Peptides and Proteins
eLS
DOI: 10.1002/9780470015902.a0001212.pub3
05/2013Cathelicidins
Handbook of Biologically Active Peptides
DOI: 10.1016/B978-0-12-385095-9.00015-4
2013Increased intracellular oxygen radical production in neutrophils during febrile episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome
Arthritis and Rheumatism
Sundqvist, M. and Wekell, P. and Osla, V. and Bylund, J. and Christenson, K. and Sävman, K. and Foell, D. and Cabral, D.A. and Fasth, A. and Berg, S. and Brown, K.L. and Karlsson, A.
DOI: 10.1002/art.38134
2013Anti-Inflammatory/Analgesics: An In-Depth Look at p38 MAP Kinases
Pharmaceutical Sciences Encyclopedia
DOI: 10.1002/9780470571224.pse446
2011Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritis
Arthritis and Rheumatism
Forsman, H. and Islander, U. and Andréasson, E. and Andersson, A. and Önnheim, K. and Karlström, A. and Sävman, K. and Magnusson, M. and Brown, K.L. and Karlsson, A.
DOI: 10.1002/art.30118
2011On the road to discovery in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome
Proceedings of the National Academy of Sciences of the United States of America
Brown, K.L. and Wekell, P. and Karlsson, A. and Berg, S.
DOI: 10.1073/pnas.1107233108
2011Differential use of chondroitin sulfate to regulate hyaluronan binding by receptor CD44 in inflammatory and interleukin 4-activated macrophages
Journal of Biological Chemistry
Ruffell, B. and Poon, G.F.T. and Lee, S.S.M. and Brown, K.L. and Tjew, S.-L. and Cooper, J. and Johnson, P.
DOI: 10.1074/jbc.M110.200790
2011Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses
Journal of Immunology
Brown, K.L. and Poon, G.F.T. and Birkenhead, D. and Pena, O.M. and Falsafi, R. and Dahlgren, C. and Karlsson, A. and Bylund, J. and Hancock, R.E.W. and Johnson, P.
DOI: 10.4049/jimmunol.1002508
2011Intracellular generation of superoxide by the phagocyte NADPH oxidase: How, where, and what for?
Free Radical Biology and Medicine
Bylund, J. and Brown, K.L. and Movitz, C. and Dahlgren, C. and Karlsson, A.
DOI: 10.1016/j.freeradbiomed.2010.09.016
2010Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity
Journal of Translational Medicine
Brown, K.L. and Falsafi, R. and Kum, W. and Hamill, P. and Gardy, J.L. and Davidson, D.J. and Turvey, S. and Finlay, B.B. and Speert, D.P. and Hancock, R.E.W.
DOI: 10.1186/1479-5876-8-6
2010Treating neonatal brain injury - Promise and inherent research challenges
Recent Patents on Inflammation and Allergy Drug Discovery
Sävman, K. and Brown, K.L.
DOI: 10.2174/187221310789895586
2010Profile of blood cells and inflammatory mediators in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome
BMC Pediatrics
Brown, K.L. and Wekell, P. and Osla, V. and Sundqvist, M. and Sävman, K. and Fasth, A. and Karlsson, A. and Berg, S.
DOI: 10.1186/1471-2431-10-65
2010G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9
Cellular Immunology
Gong, J.-H. and Nicholls, E.F. and Elliott, M.R. and Brown, K.L. and Hokamp, K. and Roche, F.M. and Cheung, C.Y.K. and Falsafi, R. and Brinkman, F.S.L. and Bowdish, D.M.E. and Hancock, R.E.W.
DOI: 10.1016/j.cellimm.2009.11.007
2010Divergent effects on phagocytosis by macrophage-derived oxygen radicals
Journal of Innate Immunity
Brown, K.L. and Christenson, K. and Karlsson, A. and Dahlgren, C. and Bylund, J.
DOI: 10.1159/000235583
2009The host defense peptide LL-37 selectively permeabilizes apoptotic leukocytes
Antimicrobial Agents and Chemotherapy
Björstad, ?. and Askarieh, G. and Brown, K.L. and Christenson, K. and Foreman, H. and Önnheim, K. and Li, H.-N. and Teneberg, S. and Maier, O. and Hoekstra, D. and Dahlgren, C. and Davidson, D.J. and Bylund, J.
DOI: 10.1128/AAC.01310-08
2009Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome
BMC Genomics
Amid, C. and Rehaume, L.M. and Brown, K.L. and Gilbert, J.G.R. and Dougan, G. and Hancock, R.E.W. and Harrow, J.L.
DOI: 10.1186/1471-2164-10-606
2009Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils
Glycobiology
Karlsson, A. and Christenson, K. and Matlak, M. and Bj?rstad, ?. and Brown, K.L. and Telemo, E. and Salomonsson, E. and Leffler, H. and Bylund, J.
DOI: 10.1093/glycob/cwn104
2009ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease
Clinical Immunology
Brown, K.L. and Bylund, J. and MacDonald, K.L. and Song-Zhao, G.X. and Elliott, M.R. and Falsafi, R. and Hancock, R.E.W. and Speert, D.P.
DOI: 10.1016/j.clim.2008.06.005
2008Phagocyte-derived reactive oxygen species as suppressors of inflammatory disease
Arthritis and Rheumatism
Björkman, L. and Dahlgren, C. and Karlsson, A. and Brown, K.L. and Bylund, J.
DOI: 10.1002/art.23941
2008Novel anti-infectives: is host defence the answer?
Current Opinion in Biotechnology
Hamill, P. and Brown, K. and Jenssen, H. and Hancock, R.E.
DOI: 10.1016/j.copbio.2008.10.006
2008Antimicrobial host defense peptides of human neutrophils - Roles in innate immunity
Anti-Infective Agents in Medicinal Chemistry
Björstad, ?. and Brown, K.L. and Forsman, H. and Dahlgren, C. and Karlsson, A. and Bylund, J.
DOI: 10.2174/187152108784911278
2008Is Innate Host Defense the Answer?
Current Opinions in Biotechnology
PubMed: 19000763
2008Antimicrobial, Host Defence Peptides and Proteins
eLS
DOI: 10.1002/9780470015902.a0001212.pub2
07/2007Complexities of targeting innate immunity to treat infection
Trends in Immunology
Brown, K.L. and Cosseau, C. and Gardy, J.L. and Hancock, R.E.W.
DOI: 10.1016/j.it.2007.04.005
2007Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-¿B
European Journal of Immunology
Bylund, J. and MacDonald, K.L. and Brown, K.L. and Mydel, P. and Collins, L.V. and Hancock, R.E.W. and Speert, D.P.
DOI: 10.1002/eji.200636651
2007Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide
Journal of Leukocyte Biology
Mookherjee, N. and Wilson, H.L. and Doria, S. and Popowych, Y. and Falsafi, R. and Yu, J. and Li, Y. and Veatch, S. and Roche, F.M. and Brown, K.L. and Brinkman, F.S.L. and Hokamp, K. and Potter, A. and Babiuk, L.A. and Griebel, P.J. and Hancock, R.E.W.
DOI: 10.1189/jlb.0106048
2006IRAK-4 mutation (Q293X): Rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells
Journal of Immunology
Davidson, D.J. and Currie, A.J. and Bowdish, D.M.E. and Brown, K.L. and Rosenberger, C.M. and Ma, R.C. and Bylund, J. and Campsall, P.A. and Puel, A. and Picard, C. and Casanova, J.-L. and Turvey, S.E. and Hancock, R.E.W. and Devon, R.S. and Speert, D.P.
DOI: 10.4049/jimmunol.177.11.8202
2006Cationic host defense (antimicrobial) peptides
Current Opinion in Immunology
Brown, K.L. and Hancock, R.E.W.
DOI: 10.1016/j.coi.2005.11.004
2006Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37
Journal of Immunology
Mookherjee, N. and Brown, K.L. and Bowdish, D.M.E. and Doria, S. and Falsafi, R. and Hokamp, K. and Roche, F.M. and Mu, R. and Doho, G.H. and Pistolic, J. and Powers, J.-P. and Bryan, J. and Brinkman, F.S.L. and Hancock, R.E.W.
DOI: 10.4049/jimmunol.176.4.2455
2006Host defence peptides from invertebrates - emerging antimicrobial strategies
Immunobiology
Hancock, R.E.W. and Brown, K.L. and Mookherjee, N.
DOI: 10.1016/j.imbio.2005.10.017
2006Cathelicidins: Cationic Host Defense and Antimicrobial Peptides
Handbook of Biologically Active Peptides
DOI: 10.1016/B978-012369442-3/50015-5
2006Regulation of hyaluronan binding by F-actin and colocalization of CD44 and phosphorylated ezrin/radixin/moesin (ERM) proteins in myeloid cells
Experimental Cell Research
Brown, K.L. and Birkenhead, D. and Lai, J.C.Y. and Li, L. and Li, R. and Johnson, P.
DOI: 10.1016/j.yexcr.2004.10.002
2005Expression of N-acetylglucosamine 6-O-sulfotransferases (GlcNAc6STs)-1 and -4 in human monocytes: GlcNAc6ST-1 is implicated in the generation of the 6-sulfo N-acetyllactosamine/Lewis x epitope on CD44 and is induced by TNF-alpha
Glycobiology
Tjew, S.L. and Brown, K.L. and Kannagi, R. and Johnson, P.
DOI: 10.1093/glycob/cwi050
2005Role of sulfation in CD44-mediated hyaluronan binding induced by inflammatory mediators in human CD14+ peripheral blood monocytes
Journal of Immunology
Brown, K.L. and Maiti, A. and Johnson, P.
DOI: 10.4049/jimmunol.167.9.5367
2001A role for the cell adhesion molecule CD44 and sulfation in leukocyte-endothelial cell adhesion during an inflammatory response?
Biochemical Pharmacology
Johnson, P. and Maiti, A. and Brown, K.L. and Li, R.
DOI: 10.1016/S0006-2952(99)00266-X
2000Assaying phage-borne peptides by phage capture on fibrinogen or streptavidin.
Biological chemistry
Bonnycastle LL and Brown KL and Tang J and Scott JK
DOI: 10.1515/bchm.1997.378.6.509
PubMed: 9224931
06/1997 - Research
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Inflammation and Cellular Redox States
It is well understood that highly toxic oxidants called ‘reactive oxygen species (ROS)’ are produced by phagocytic cells as part of the innate immune response to infection. In recent years, ROS and consequently the oxidation-reduction (redox) state of immune cells have been recognized as key players in the inflammatory response to both infectious and non-infectious cues. Pediatric diseases with inflammatory complications and signs of redox imbalance include chronic granulomatous disease (CGD), cystic fibrosis, and the autoinflammatory diseases SAPHO, PFAPA, TRAPS and FMF. Whether oxidants suppress or promote inflammatory signaling and to what extent they influence the biology of an inflammatory response remains controversial. This project aims to understand redoxsensitive signaling molecules in the context of inflammatory disease and their potential as novel therapeutic targets.Childhood Autoinflammatory Diseases
The autoinflammatory family of diseases share features of unprovoked, recurrent attacks of inflammation with fever, rash, body pain/arthritis, and organ inflammation. The family includes a handful of defined monogenic diseases, but more than 80% of cases do not have a known cause. This collaborative project will establish a clinical home at BCCH for children with autoinflammatory disorders, and develop in parallel a robust, longitudinal collection of clinical data and biological samples for research. Laboratory initiatives will evaluate the clinical potential of previously identified, putative biomarkers of autoinflammation, and seek to uncover new disease etiologies.Primary Childhood Vasculitis
Chronic primary vasculitis describes a group of rare, life-threatening diseases that have in common inflammation of blood vessels in vital organs such as kidneys, lungs and brain. The challenge in treating children with vasculitis is balancing the risk of under treating aggressive disease with the potential damaging side-effects of prolonged use of drugs. This project uses an established international web-based registry to collect clinical information from 50 or more centers worldwide, with approximately 20 centres contributing paired biological samples (DNA, RNA, plasma, serum, urine). The goal is to elucidate subclinical (molecular/cellular) features which help to classify, define and direct optimal treatment for children with vasculitis.Research Group MembersSarah Bowers, PhD student
Steph Hughes
Nathan Millward, Summer Student
Poorna Murali, Master's Student
Sabrina Sefton, Masters Student
Kiran Toor
Sandra Tsai, Master's Student
Eric Zhu, INSPIRE TRAINEE
