BCCHR Researchers Find a Researcher

Philipp Lange

(he/him)

PhD

Investigator, Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital
Canada Research Chair in Translational Proteogenomics of Pediatric Malignancies

My research team strives to develop new diagnostic and therapeutic approaches to detect and treat children suffering from cancer earlier, better and with reduced impact on their life.

The fundamental question is how cancer cells are different from healthy, normal cells? If we understand this we will be able to better detect and kill cancer while leaving the rest of the body untouched.

Our research focuses on proteins, the structural and functional building blocks of a cell. To do this we combine genomics and proteomics, a technology that enables us to monitor all of the proteins in our body and detect how they are changed in childhood cancer. We then use computational approaches to further analyze and integrate our findings and to make them accessible to clinicians and fellow scientists around the world.

Academic Affiliations

Associate Professor, , Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia
Research Theme: Childhood Diseases
Research Group(s): Childhood Cancer and Blood Research; Immunity in Health and Disease; Rare Diseases

Contact Information

Assistant

Brenda Tse

brenda.tse@ubc.ca

Location

950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4

(604) 875-2000 ext. 6015

philipp.lange@ubc.ca

Lange Lab

ProteoForge: An Imputation-Aware Framework for Differential Proteoform Discovery in Bottom-Up Proteomics

Enes K. Ergin and Agustina Conrrero and Kirsty M. Ferguson and Philipp F. Lange

DOI: 10.64898/2025.12.12.694008

12 / 2025

Proteomics and personalized PDX models identify treatment for a progressive malignancy within an actionable timeframe

EMBO Molecular Medicine

Barnabas, G.D. and Bhat, T.A. and Goebeler, V. and Leclair, P. and Azzam, N. and Melong, N. and Anderson, C. and Gom, A. and An, S. and Ergin, E.K. and Shen, Y. and Conrrero, A. and Mungall, A.J. and Mungall, K.L. and Maxwell, C.A. and Reid, G.S.D. and Hirst, M. and Jones, S. and Chan, J.A. and Senger, D.L. and Berman, J.N. and Parker, S.J. and Bush, J.W. and Strahlendorf, C. and Deyell, R.J. and Lim, C.J. and Lange, P.F.

DOI: 10.1038/s44321-025-00212-8

Granzyme B cleaves tenascin-C to release its C-terminal domain in rheumatoid arthritis

Jci Insight

Aubert, A. and Liu, A. and Kao, M. and Goeres, J. and Richardson, K.C. and Nierves, L. and Jung, K. and Nabai, L. and Zhao, H. and Orend, G. and Krawetz, R. and Lange, P.F. and Younger, A. and Chan, J. and Granville, D.J.

DOI: 10.1172/jci.insight.181935

The E-Ret mouse is a novel model of hyperdiploid B-cell acute lymphoblastic leukemia

Leukemia

Farrokhi, A. and Atre, T. and Rever, J. and Fidanza, M. and Duey, W. and Salitra, S. and Myung, J. and Guo, M. and Jo, S. and Uzozie, A. and Baharvand, F. and Rolf, N. and Auer, F. and Hauer, J. and Grupp, S.A. and Eydoux, P. and Lange, P.F. and Seif, A.E. and Maxwell, C.A. and Reid, G.S.D.

DOI: 10.1038/s41375-024-02221-x

Proteomics and personalized patient-derived xenograft models identify treatment opportunities for a progressive malignancy within a clinically actionable timeframe and change care

Medrxiv

Barnabas, G.D. and Bhat, T.A. and Goebeler, V. and Leclair, P. and Azzam, N. and Melong, N. and Anderson, C. and Gom, A. and An, S. and Ergin, E.K. and Shen, Y. and Mungall, A.J. and Mungall, K.L. and Maxwell, C.A. and Reid, G.S.D. and Hirst, M. and Jones, S. and Chan, J.A. and Senger, D.L. and Berman, J.N. and Parker, S.J. and Bush, J.W. and Strahlendorf, C. and Deyell, R.J. and Lim, C.J. and Lange, P.F.

DOI: 10.1101/2024.07.04.24309923

Developing a soft micropatterned substrate to enhance maturation of human induced pluripotent stem cell-derived cardiomyocytes

Acta Biomaterialia

Maaref, Y. and Jannati, S. and Jayousi, F. and Lange, P. and Akbari, M. and Chiao, M. and Tibbits, G.F.

DOI: 10.1016/j.actbio.2024.10.029

Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by aging

Biorxiv

Molzahn, C. and Kuechler, E. and Nierves, L. and Cole, G. and Wang, J. and Cashman, N. and Karsan, A. and Lange, P.F. and Gsponer, J. and Mayor, T.

DOI: 10.1101/2024.02.28.582597

Statistical Testing for Protein Equivalence Identifies Core Functional Modules Conserved across 360 Cancer Cell Lines and Presents a General Approach to Investigating Biological Systems

Journal of Proteome Research

Ergin, E.K. and Myung, J.J. and Lange, P.F.

DOI: 10.1021/acs.jproteome.4c00131

ASAP-Automated Sonication-Free Acid-Assisted Proteomes-from Cells and FFPE Tissues

Analytical Chemistry

Georgina D. Barnabas and Verena Goebeler and Janice Tsui and Jonathan W. Bush and Philipp F. Lange

DOI: 10.1021/acs.analchem.2c04264

02 / 2023

Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C+/- During Development

Biorxiv

Shafaatalab, S. and Li, A.Y. and Jayousi, F. and Maaref, Y. and Dababneh, S. and Hamledari, H. and Baygi, D.H. and Barszczewski, T. and Ruprai, B. and Jannati, S. and Nagalingam, R. and Cool, A.M. and Langa, P. and Chiao, M. and Roston, T. and Solaro, R.J. and Sanatani, S. and Toepfer, C. and Lindert, S. and Lange, P. and Tibbits, G.F.

DOI: 10.1101/2023.06.06.542948

RNA Polymerase II transcription independent of TBP in murine embryonic stem cells

Elife

Kwan, J.Z.J. and Nguyen, T.F. and Uzozie, A.C. and Budzynski, M.A. and Cui, J. and Lee, J.M.C. and Van Petegem, F. and Lange, P.F. and Teves, S.S.

DOI: 10.7554/eLife.83810

Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts

bioRxiv

Nagalingam, R.S. and Jayousi, F. and Hamledari, H. and Baygi, D.H. and Dababneh, S. and Lindsay, C. and Dixon, I.M.C. and Geltink, R.K. and Lange, P.F. and Rose, R.A. and Czubryt, M.P. and Tibbits, G.F.

DOI: 10.1101/2023.10.08.561455

Shift of the insoluble content of the proteome in the aging mouse brain

Proceedings of the National Academy of Sciences of the United States of America

Molzahn, C. and Kuechler, E.R. and Zemlyankina, I. and Nierves, L. and Ali, T. and Cole, G. and Wang, J. and Albu, R.F. and Zhu, M. and Cashman, N.R. and Gilch, S. and Karsan, A. and Lange, P.F. and Gsponer, J. and Mayor, T.

DOI: 10.1073/pnas.2310057120

Positional proteomics: is the technology ready to study clinical cohorts?

Expert Review of Proteomics

Lange, P.F. and Schilling, O. and Huesgen, P.F.

DOI: 10.1080/14789450.2023.2272046

Adaptation of the Th-MYCN Mouse Model of Neuroblastoma for Evaluation of Disseminated Disease

International Journal of Molecular Sciences

Rahavi, S.M. and Aletaha, M. and Farrokhi, A. and Lorentzian, A. and Lange, P.F. and Maxwell, C.A. and Lim, C.J. and Reid, G.S.D.

DOI: 10.3390/ijms241512071

Title: Inducing an oxidized redox-balance improves anti-tumor CD8+ T cell function

Biorxiv

Oh, J.H. and Cederberg, R.A. and Tanaka, E. and Bopp, L. and Ser, T. and Niyyati, S. and Patterson, A.E. and Amanat, N. and Dutra, J. and Ye, P. and Clark, M. and Ward-Hartstonge, K. and Archambault, A.-S. and Tsui, J. and Lange, P.F. and Tsai, S. and Bruce Verchere, C. and Park, Y. and Fabri, M. and Bennewith, K.L. and Klein Geltink, R.I.

DOI: 10.1101/2023.03.27.533229

Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric acute lymphoblastic leukemia

Nature Communications

Lorentzian, A.C. and Rever, J. and Ergin, E.K. and Guo, M. and Akella, N.M. and Rolf, N. and James Lim, C. and Reid, G.S.D. and Maxwell, C.A. and Lange, P.F.

DOI: 10.1038/s41467-023-42701-9

SQuAPP"simple quantitative analysis of proteins and PTMs

Bioinformatics

Enes K Ergin and Anuli C Uzozie and Siyuan Chen and Ye Su and Philipp F Lange

DOI: 10.1093/bioinformatics/btac628

10 / 2022

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

Nature Communications

Zhengcheng He and Ryan Ghorayeb and Susanna Tan and Ke Chen and Amanda C. Lorentzian and Jack Bottyan and Syed Mohammed Musheer Aalam and Miguel Angel Pujana and Philipp F. Lange and Nagarajan Kannan and Connie J. Eaves and Christopher A. Maxwell

DOI: 10.1038/s41467-022-29885-2

04 / 2022

Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma

Lorenz Nierves and Jian Guo and Siyuan Chen and Janice Tsui and Anuli Uzozie and Jonathan W. Bush and Tao Huan and Philipp F. Lange

DOI: 10.1101/2022.03.30.486272

04 / 2022

Persistence of targetable lesions, predicted therapy sensitivity and proteomes through disease evolution in pediatric acute lymphoblastic leukemia

Amanda C. Lorentzian and Jenna Rever and Enes K. Ergin and Meiyun Guo and Neha M. Akella and Nina Rolf and C. James Lim and Gregor S.D. Reid and Christopher A. Maxwell and Philipp F. Lange

DOI: 10.1101/2022.03.04.22271927

03 / 2022

Sensitive Identification of Known and Unknown Protease Activities by Unsupervised Linear Motif Deconvolution

Analytical Chemistry

Anuli C. Uzozie and Theodore G. Smith and Siyuan Chen and Philipp F. Lange

DOI: 10.1021/acs.analchem.1c04937

02 / 2022

A cross-standardized flow cytometry platform to assess phenotypic stability in precursor B-cell acute lymphoblastic leukemia (B-ALL) xenografts

Cytometry Part A

Nina Rolf and Lorraine Y. T. Liu and Angela Tsang and Philipp F. Lange and Chinten James Lim and Christopher A. Maxwell and Suzanne M. Vercauteren and Gregor S. D. Reid

DOI: 10.1002/cyto.a.24473

01 / 2022

HUNTER: Sensitive Automated Characterization of Proteolytic Systems by N Termini Enrichment from Microscale Specimen

Methods in Molecular Biology

Uzozie, A.C. and Tsui, J. and Lange, P.F.

DOI: 10.1007/978-1-0716-2124-0_8

Shift of the insoluble content of the proteome in aging mouse brain

bioRxiv

Molzahn, C. and Kuechler, E. and Zemlyankina, I. and Nieves, L. and Ali, T. and Cole, G. and Wang, J. and Albu, R.F. and Zhu, M. and Cashman, N. and Gilch, S. and Karsan, A. and Lange, P.F. and Gsponer, J. and Mayor, T.

DOI: 10.1101/2022.12.13.520290

Modification of BRCA1-associated breast cancer risk by HMMR overexpression

Nature Communications

Mateo, F. and He, Z. and Mei, L. and de Garibay, G.R. and Herranz, C. and Garca, N. and Lorentzian, A. and Baiges, A. and Blommaert, E. and Gmez, A. and Mirallas, O. and Garrido-Utrilla, A. and Palomero, L. and Espn, R. and Extremera, A.I. and Soler-Mons, M.T. and Petit, A. and Li, R. and Brunet, J. and Chen, K. and Tan, S. and Eaves, C.J. and McCloskey, C. and Hakem, R. and Khokha, R. and Lange, P.F. and Lzaro, C. and Maxwell, C.A. and Pujana, M.A.

DOI: 10.1038/s41467-022-29335-z

Isolation of Detergent Insoluble Proteins from Mouse Brain Tissue for Quantitative Analysis Using Data Independent Acquisition (DIA)

Methods in Molecular Biology

Molzahn, C. and Nierves, L. and Lange, P.F. and Mayor, T.

DOI: 10.1007/978-1-0716-2124-0_3

Detectability of Biotin Tags by LC-MS/MS

Journal of Proteome Research

Nierves, L. and Lange, P.F.

DOI: 10.1021/acs.jproteome.0c01049

Robust unsupervised deconvolution of linear motifs characterizes 68 protein modifications at proteome scale

Scientific Reports

Smith, T.G. and Uzozie, A.C. and Chen, S. and Lange, P.F.

DOI: 10.1038/s41598-021-01971-3

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

Journal of Experimental and Clinical Cancer Research

Uzozie, A.C. and Ergin, E.K. and Rolf, N. and Tsui, J. and Lorentzian, A. and Weng, S.S.H. and Nierves, L. and Smith, T.G. and Lim, C.J. and Maxwell, C.A. and Reid, G.S.D. and Lange, P.F.

DOI: 10.1186/s13046-021-01835-8

Fold-Change Compression: An Unexplored but Correctable Quantitative Bias Caused by Nonlinear Electrospray Ionization Responses in Untargeted Metabolomics

Analytical Chemistry

Yu, H. and Xing, S. and Nierves, L. and Lange, P.F. and Huan, T.

DOI: 10.1021/acs.analchem.0c00246

Multi-Omic Approach to Identify Phenotypic Modifiers Underlying Cerebral Demyelination in X-Linked Adrenoleukodystrophy

Frontiers in Cell and Developmental Biology

Richmond, P.A. and van der Kloet, F. and Vaz, F.M. and Lin, D. and Uzozie, A. and Graham, E. and Kobor, M. and Mostafavi, S. and Moerland, P.D. and Lange, P.F. and van Kampen, A.H.C. and Wasserman, W.W. and Engelen, M. and Kemp, S. and van Karnebeek, C.D.M.

DOI: 10.3389/fcell.2020.00520

Tumor Variant Identification That Accounts for the Unique Molecular Landscape of Pediatric Malignancies

JNCI Cancer Spectrum

Amanda Lorentzian and Jaclyn A Biegel and D Gigi Ostrow and Nina Rolf and Chi-Chao Liu and S Rod Rassekh and Rebecca J Deyell and Timothy Triche and Kirk R Schultz and Jacob Rozmus and Gregor S D Reid and C James Lim and Philipp F Lange and Christopher A Maxwell

DOI: 10.1093/jncics/pky079

01 / 2019

Origins and clinical relevance of proteoforms in pediatric malignancies

Expert Review of Proteomics

Lorentzian, A. and Uzozie, A. and Lange, P.F.

DOI: 10.1080/14789450.2019.1575206

Sensitive determination of proteolytic proteoforms in limited microscale proteome samples

Molecular and Cellular Proteomics

Weng, S.S.H. and Demir, F. and Ergin, E.K. and Dirnberger, S. and Uzozie, A. and Tuscher, D. and Nierves, L. and Tsui, J. and Huesgen, P.F. and Lange, P.F.

DOI: 10.1074/mcp.TIR119.001560

HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development

eLife

Connell, M. and Chen, H. and Jiang, J. and Kuan, C.-W. and Fotovati, A. and Chu, T.L.H. and He, Z. and Lengyell, T.C. and Li, H. and Kroll, T. and Li, A.M. and Goldowitz, D. and Frappart, L. and Ploubidou, A. and Patel, M.S. and Pilarski, L.M. and Simpson, E.M. and Lange, P.F. and Allan, D.W. and Maxwell, C.A.

DOI: 10.7554/eLife.28672

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors

Cell Reports

Prudova, A. and Gocheva, V. and auf dem Keller, U. and Eckhard, U. and Olson, O.C. and Akkari, L. and Butler, G.S. and Fortelny, N. and Lange, P.F. and Mark, J.C. and Joyce, J.A. and Overall, C.M.

DOI: 10.1016/j.celrep.2016.06.086

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses

Matrix Biology

Eckhard, U. and Huesgen, P.F. and Schilling, O. and Bellac, C.L. and Butler, G.S. and Cox, J.H. and Dufour, A. and Goebeler, V. and Kappelhoff, R. and auf dem Keller, U. and Klein, T. and Lange, P.F. and Marino, G. and Morrison, C.J. and Prudova, A. and Rodriguez, D. and Starr, A.E. and Wang, Y. and Overall, C.M.

DOI: 10.1016/j.matbio.2015.09.003

Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14

Data in Brief

DOI: 10.1016/j.dib.2016.02.036

Proteome TopFIND 3.0 with TopFINDer and PathFINDer: Database and analysis tools for the association of protein termini to pre- and post-translational events

Nucleic Acids Research

Fortelny, N. and Yang, S. and Pavlidis, P. and Lange, P.F. and Overall, C.M.

DOI: 10.1093/nar/gku1012

COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer

Molecular Cancer

Hofmann, B.T. and Schlter, L. and Lange, P. and Mercanoglu, B. and Ewald, F. and Flster, A. and Picksak, A.-S. and Harder, S. and El Gammal, A.T. and Grupp, K. and Gngr, C. and Drenckhan, A. and Schlter, H. and Wagener, C. and Izbicki, J.R. and Jcker, M. and Bockhorn, M. and Wolters-Eisfeld, G.

DOI: 10.1186/s12943-015-0386-1

Active Site Specificity Profiling of the Matrix Metalloproteinase Family: Proteomic Identification of 4,300 Cleavage Sites by MMPs 1, 2, 3, 7, 8, 9, 12, 13, and 14.

LysargiNase and tryptic digest of MDA-MB 231 cell lysates

Network Analyses Reveal Pervasive Functional Regulation Between Proteases in the Human Protease Web

PLoS Biology

Fortelny, N. and Cox, J.H. and Kappelhoff, R. and Starr, A.E. and Lange, P.F. and Pavlidis, P. and Overall, C.M.

DOI: 10.1371/journal.pbio.1001869

Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease

Proteomics - Clinical Applications

Huesgen, P.F. and Lange, P.F. and Overall, C.M.

DOI: 10.1002/prca.201300104

Annotating N termini for the human proteome project: N termini and Na-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome

Journal of Proteome Research

Lange, P.F. and Huesgen, P.F. and Nguyen, K. and Overall, C.M.

DOI: 10.1021/pr401191w

Characterization of LysargiNase for use in phosphoproteomics experiments, partII

LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification

Nature Methods

Huesgen, P.F. and Lange, P.F. and Rogers, L.D. and Solis, N. and Eckhard, U. and Kleifeld, O. and Goulas, T. and Gomis-Rth, F.X. and Overall, C.M.

DOI: 10.1038/nmeth.3177

Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis

Cell Reports

Bellac, C.L. and Dufour, A. and Krisinger, M.J. and Loonchanta, A. and Starr, A.E. and auf dem Keller, U. and Lange, P.F. and Goebeler, V. and Kappelhoff, R. and Butler, G.S. and Burtnick, L.D. and Conway, E.M. and Roberts, C.R. and Overall, C.M.

DOI: 10.1016/j.celrep.2014.09.006

Proteomic Amino-Termini Profiling Reveals Targeting Information for Protein Import into Complex Plastids

PLoS ONE

Huesgen, P.F. and Alami, M. and Lange, P.F. and Foster, L.J. and Schrder, W.P. and Overall, C.M. and Green, B.R.

DOI: 10.1371/journal.pone.0074483

Protein TAILS: When termini tell tales of proteolysis and function

Current Opinion in Chemical Biology

Lange, P.F. and Overall, C.M.

DOI: 10.1016/j.cbpa.2012.11.025

TopFIND 2.0 - Linking protein termini with proteolytic processing and modifications altering protein function

Nucleic Acids Research

Lange, P.F. and Huesgen, P.F. and Overall, C.M.

DOI: 10.1093/nar/gkr1025

Towards kit-like 18F-labeling of marimastat, a noncovalent inhibitor drug for in vivo PET imaging cancer associated matrix metalloproteases

Medchemcomm

Li, Y. and Ting, R. and Harwig, C.W. and Auf Dem Keller, U. and Bellac, C.L. and Lange, P.F. and Inkster, J.A.H. and Schaffer, P. and Adam, M.J. and Ruth, T.J. and Overall, C.M. and Perrin, D.M.

DOI: 10.1039/c1md00117e

TopFIND, a knowledgebase linking protein termini with function

Nature Methods

Lange, P.F. and Overall, C.M.

DOI: 10.1038/nmeth.1669

Novel matrix metalloproteinase inhibitor [18F]marimastat- aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer

Cancer Research

Auf Dem Keller, U. and Bellac, C.L. and Li, Y. and Lou, Y. and Lange, P.F. and Ting, R. and Harwig, C. and Kappelhoff, R. and Dedhar, S. and Adam, M.J. and Ruth, T.J. and Bnard, F. and Perrin, D.M. and Overall, C.M.

DOI: 10.1158/0008-5472.CAN-10-1584

ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function

GBM Annual Spring meeting Mosbach 2007

Jens C. Fuhrmann and Philipp F. Lange and Lena Wartosch and Thomas J. Jentsch

DOI: 10.1240/sav_gbm_2007_m_001701

03 / 2007

ClC-7 requires Ostm1 as a -subunit to support bone resorption and lysosomal function

Nature

Lange, P.F. and Wartosch, L. and Jentsch, T.J. and Fuhrmann, J.C.

DOI: 10.1038/nature04535

Current Projects

The overall objective of my team's research is to monitor and detect aberrant protein presence and function in cancer and exploit this difference to diagnose and treat cancer and improve the wellbeing of cancer survivors.

We are particularly interested in how the post-translational modification of proteins affects cancer progression and secondary disease, which can hit childhood cancer survivors years after successful treatment. After translation proteins can be modified by, for example, proteolytic processing or phosphorylation. This creates a repertoire of "proteoforms", which are all the variant and modified protein products of a single gene. They often differ in their localization, function and interaction with other proteins.

Our research program follows four main axes that inform each other:
I: We use proteo-genomics to study differences in tissue specimen from children suffering from select cancers and healthy individuals, and translate these findings into a new diagnostic and treatment approach.
II: We integrate cell biology, biochemistry, genomics, proteomics and bioinformatics to study the role of post-translational modification in the regulation of select cell signaling networks. By investigating patient-derived cells and mouse models we strive to identify new ways of altering these signaling networks to improve drug efficacy and reduce side effects.
III: Computational biology plays an integral role in our research. Our main focus is the development of algorithms for multi-scale data integraction, protein function analysis, pattern recognition and de-convolution of network effects in complex systems. Building on these we develop new biological knowledgebases and applications to improve the functional analysis of genomics and proteomics data and to guide personalized treatment decisions.
IV: We continuously strive to improve existing- and develop new technologies for the mass spectrometric analysis of complex biological specimen enabling a more comprehensive, specific and sensitive investigation of smaller biopsies.

My research team is embedded in the Michael Cuccione Childhood Cancer Research Program and affiliated with the BC Cancer Research Centre and BC Children’s Hospital. This creates a stimulating environment in which we work closely with world-class experts in clinical oncology, cancer biology, genomics and computer sciences.

Grants

"Proteolytic protein termini as a new strategy for cancer cell-specific therapy," Innovation Grant, Canadian Cancer Society, 2016-2018

"Bioinformatics resources for genomewide assessment of protein function at the proteoform level," NSERC Discovery Grant, $28,000/ year, 2018-2023

Honours & Awards

Michael Smith Health Foundation Research Scholar Award (2016)

Canada Research Chair Tier 2 Award in Translational Proteomics of Childhood

Malignancies (2015-2020)

Feodor Lynen Research Fellowship for Postdoctoral Research (Alexander von Humboldt Foundation) (2009-2011)

Joint Michael Smith Foundation for Health Research & Breast Cancer Society of Canada Research Award (2011-2012)

Related News

Every day, our researchers work towards breakthroughs to transform the lives of kids in BC and around the world. Learn about our latest innovations and advancements in child health.

bcchr news

Personalized, precise, powerful: How BCCHR researchers are changing childhood cancer care
When a child’s cancer returns after conventional treatment, families often find themselves in uncharted territory — scared, exhausted, and grasping for answers. But thanks to a remarkable collaboration between researchers, clinicians, and national research networks, new pediatric cancer treatment options are emerging.
Read more
BCCHR researchers develop new way to match young cancer patients with the right drugs
A pan-Canadian team has developed a new way to quickly find personalized treatments for young cancer patients, by growing their tumours in chicken eggs and analyzing their proteins.
Read more
New study shows the potential of new treatment strategies for most common childhood cancer
Published today (November 21, 2023) in Nature Communications, the study found that some treatable aspects of a child’s cancer that are present at diagnosis still remain if the disease returns. This finding suggests that clinicians can start looking for precision treatments for a child’s cancer immediately after diagnosis, rather than waiting until the cancer has…
Read more

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Philipp Lange

(he/him)

PhD

Investigator, Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital Canada Research Chair in Translational Proteogenomics of Pediatric Malignancies

Academic Affiliations

Contact Information

Assistant

Location

Publications

Collapse

Expand

ProteoForge: An Imputation-Aware Framework for Differential Proteoform Discovery in Bottom-Up Proteomics

Proteomics and personalized PDX models identify treatment for a progressive malignancy within an actionable timeframe

Granzyme B cleaves tenascin-C to release its C-terminal domain in rheumatoid arthritis

The E-Ret mouse is a novel model of hyperdiploid B-cell acute lymphoblastic leukemia

Proteomics and personalized patient-derived xenograft models identify treatment opportunities for a progressive malignancy within a clinically actionable timeframe and change care

Developing a soft micropatterned substrate to enhance maturation of human induced pluripotent stem cell-derived cardiomyocytes

Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by aging

Statistical Testing for Protein Equivalence Identifies Core Functional Modules Conserved across 360 Cancer Cell Lines and Presents a General Approach to Investigating Biological Systems

ASAP-Automated Sonication-Free Acid-Assisted Proteomes-from Cells and FFPE Tissues

Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C+/- During Development

RNA Polymerase II transcription independent of TBP in murine embryonic stem cells

Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts

Shift of the insoluble content of the proteome in the aging mouse brain

Positional proteomics: is the technology ready to study clinical cohorts?

Adaptation of the Th-MYCN Mouse Model of Neuroblastoma for Evaluation of Disseminated Disease

Title: Inducing an oxidized redox-balance improves anti-tumor CD8+ T cell function

Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric acute lymphoblastic leukemia

SQuAPP"simple quantitative analysis of proteins and PTMs

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma

Persistence of targetable lesions, predicted therapy sensitivity and proteomes through disease evolution in pediatric acute lymphoblastic leukemia

Sensitive Identification of Known and Unknown Protease Activities by Unsupervised Linear Motif Deconvolution

A cross-standardized flow cytometry platform to assess phenotypic stability in precursor B-cell acute lymphoblastic leukemia (B-ALL) xenografts

HUNTER: Sensitive Automated Characterization of Proteolytic Systems by N Termini Enrichment from Microscale Specimen

Shift of the insoluble content of the proteome in aging mouse brain

Modification of BRCA1-associated breast cancer risk by HMMR overexpression

Isolation of Detergent Insoluble Proteins from Mouse Brain Tissue for Quantitative Analysis Using Data Independent Acquisition (DIA)

Detectability of Biotin Tags by LC-MS/MS

Robust unsupervised deconvolution of linear motifs characterizes 68 protein modifications at proteome scale

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

Fold-Change Compression: An Unexplored but Correctable Quantitative Bias Caused by Nonlinear Electrospray Ionization Responses in Untargeted Metabolomics

Multi-Omic Approach to Identify Phenotypic Modifiers Underlying Cerebral Demyelination in X-Linked Adrenoleukodystrophy

Tumor Variant Identification That Accounts for the Unique Molecular Landscape of Pediatric Malignancies

Origins and clinical relevance of proteoforms in pediatric malignancies

Sensitive determination of proteolytic proteoforms in limited microscale proteome samples

HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses

Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14

Proteome TopFIND 3.0 with TopFINDer and PathFINDer: Database and analysis tools for the association of protein termini to pre- and post-translational events

COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer

Active Site Specificity Profiling of the Matrix Metalloproteinase Family: Proteomic Identification of 4,300 Cleavage Sites by MMPs 1, 2, 3, 7, 8, 9, 12, 13, and 14.

LysargiNase and tryptic digest of MDA-MB 231 cell lysates

Network Analyses Reveal Pervasive Functional Regulation Between Proteases in the Human Protease Web

Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease

Annotating N termini for the human proteome project: N termini and Na-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome

Characterization of LysargiNase for use in phosphoproteomics experiments, partII

LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification

Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis

Proteomic Amino-Termini Profiling Reveals Targeting Information for Protein Import into Complex Plastids

Protein TAILS: When termini tell tales of proteolysis and function

TopFIND 2.0 - Linking protein termini with proteolytic processing and modifications altering protein function

Towards kit-like 18F-labeling of marimastat, a noncovalent inhibitor drug for in vivo PET imaging cancer associated matrix metalloproteases

TopFIND, a knowledgebase linking protein termini with function

Novel matrix metalloproteinase inhibitor [18F]marimastat- aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer

ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function

ClC-7 requires Ostm1 as a -subunit to support bone resorption and lysosomal function

Research

Collapse

Expand

Current Projects

Grants

Honours & Awards

Related News

Personalized, precise, powerful: How BCCHR researchers are changing childhood cancer care

BCCHR researchers develop new way to match young cancer patients with the right drugs

New study shows the potential of new treatment strategies for most common childhood cancer

Our Research

Stay in the Know

Investigator, Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital
Canada Research Chair in Translational Proteogenomics of Pediatric Malignancies