Overview

My research focuses on three principal areas:

Clinical outcomes and innovation in the treatment of pediatric hydrocephalus: BC Children’s Hospital is one of only two Canadian centres in the Hydrocephalus Clinical Research Network

Outcomes, novel therapies and imaging findings in concussion and mild traumatic brain injury: as a researcher in the Canada North Concussion Network, a Winnipeg-based consortium, we are investigating novel imaging techniques to diagnose and monitor recovery from concussion

Bioethics/Neuroethics: I conduct research in various aspects of bioethics as it relates to neurosurgery including conflicts of interest in neurosurgical research, ethical issues in fetal surgery for spina bifida and the role of ethics education in neurosurgery training

Publications

Endovascular management of a complex intracranial internal carotid artery dissection in an adolescent
Interdisciplinary Neurosurgery
Mohamed Somji, Frederick Adam Zeiler, Patrick Joseph McDonald, Zulfiqar Kaderali
DOI: 10.1016/j.inat.2016.04.005
2016

Secondary vein of Galen malformation with hydrocephalus: Treated with combined endovascular and endoscopic approach
Interdisciplinary Neurosurgery
F.A. Zeiler, J. Silvaggio, D. Iancu, P.J. McDonald
DOI: 10.1016/j.inat.2015.07.003
09/2015

Craniopharyngioma
Pediatric Neuro-oncology
David Phillips, Patrick J. McDonald, Ute Bartels
DOI: 10.1007/978-1-4939-1541-5_16
2015

Informed Consent
Neurosurgical Ethics in Practice: Value-based Medicine
Patrick McDonald
DOI: 10.1007/978-3-642-54980-9_5
2014

Conflict of Interest
Neurosurgical Ethics in Practice: Value-based Medicine
Patrick McDonald
DOI: 10.1007/978-3-642-54980-9_20
2014

Gamma Knife Radiosurgery of Cavernous Sinus Meningiomas: An Institutional Review
Can J Neurol Sci.
F. A. Zeiler, P. J. McDonald, A. M. Kaufmann, D. Fewer, J. Butler, G. Schroeder, M. West
DOI: 10.1017/s0317167100015572
11/2012

Decompressive Craniectomy in Traumatic Brain Injury: The Edge Effect
Can J Neurol Sci.
F. A. Zeiler, P. J. McDonald
DOI: 10.1017/s0317167100015419
09/2012

Novel MRI Changes After Gamma Knife for Hypothalamic Hamartoma in a Child
Can J Neurol Sci.
Krystal Thorington, Frederick A. Zeiler, Patrick J. McDonald
DOI: 10.1017/s031716710001413x
07/2012

Isolated central sleep apnea in type I Chiari malformation: improvement after surgery.
Spence J, Pasterkamp H, McDonald PJ
DOI: 10.1002/ppul.21294
PubMed: 20848584
11/2010

Spinal Cord Transection in a Child After Non-Penetrating Trauma
Can J Neurol Sci.
Richard Farb, David Pelz, Fred A. Zeiler, Patrick J. McDonald
DOI: 10.1017/s0317167100010337
05/2010

Epidural Spinal Tumors in Children
Oncology of CNS Tumors
Krystal Thorington, Colin Kazina, Patrick McDonald
DOI: 10.1007/978-3-642-02874-8_49
2010

Meningiomas in Children
Oncology of CNS Tumors
Abhaya V. Kulkarni, Patrick J. McDonald
DOI: 10.1007/978-3-642-02874-8_39
2010

Head injuries in winter sports: downhill skiing, snowboarding, sledding, snowmobiling, ice skating and ice hockey.
Chaze B, McDonald P
DOI: 10.1016/j.pmr.2008.10.016
PubMed: 19084778
02/2009

Middle Cranial Fossa Arachnoid Cysts That Come and Go
Pediatr Neurosurg
Patrick J. McDonald, James T. Rutka
DOI: 10.1159/000121161
03/2008

Calcium chelation improves spatial learning and synaptic plasticity in aged rats.
Tonkikh A, Janus C, El-Beheiry H, Pennefather PS, Samoilova M, McDonald P, Ouanounou A, Carlen PL
DOI: 10.1016/j.expneurol.2005.06.014
PubMed: 16039651
02/2006

There's a Bug in Your Head
Hastings Center Report
Patrick McDonald
DOI: 10.1353/hcr.2006.0046
2006

Midbrain Gliomas
Textbook of Neuro-Oncology
Charles Matouk, Patrick McDonald, James M. Drake
DOI: 10.1016/b978-0-7216-8148-1.50081-4
2005

Antiepileptic efficacy of topiramate: assessment in two in vitro seizure models.
Jahromi SS, Pelletier MR, McDonald PJ, Khosravani H, Carlen PL
DOI: 10.1016/s0006-8993(00)02410-0
PubMed: 10924671
07/2000

Primary intracranial fibrosarcoma with intratumoral hemorrhage: neuropathological diagnosis with review of the literature.
McDonald P, Guha A, Provias J
DOI: 10.1023/a:1005723013144
PubMed: 9266449
11/1997

Meningiomas
Neuro-Oncology of CNS Tumors
Abhaya V. Kulkarni, Patrick McDonald
DOI: 10.1007/3-540-31260-9_38

Epidural Spinal Tumors in Children
Neuro-Oncology of CNS Tumors
Colin Kazina, Patrick McDonald
DOI: 10.1007/3-540-31260-9_48

Research

Current Projets
Conflicts of interest in neurosurgical research- we are determining the scope and disclosure of financial conflicts of interest in published neurosurgical research.

Current Projects
Novel neuro-imaging assessment of cerebrovascular reactivity and default-mode networks in adolescent sports-related concussion- we are attempting to develop an MRI based test to give an objective measure of recovery following sports related concussion.

Current Projects
Targeting the CSF microbiota to optimize CSF shunt infection treatment- we are analyzing the spinal fluid in children with shunts used to treat hydrocephalus in order to determine the best way to prevent and manage shunt infections.

Grants

Targeting the CSF microbiota to optimize CSF shunt infection treatment Source: National Institutes of Health (NINDS)- USA Role: Local Principal Investigator

A randomized controlled trial of anterior versus posterior entry site for cerebrospinal fluid shunt insertion 2015-2018 Source: Patient-Centered Outcomes Research Institute Grant #CER-1403013857 Role: Local Principal Investigator

Honours & Awards

University of Manitoba Outreach Award

Research Group Members

Anahat Sahota, Medical Student